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  1 / 6904 MEDLINE  
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[PMID]:29381950
[Au] Autor:Bai S; Zhang H; Li Z; Li D; Li H
[Ad] Endereço:Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China.
[Ti] Título:A 53-year-old man with a sclerosing rib lesion: A case report.
[So] Source:Medicine (Baltimore);96(47):e8692, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Sclerosing osteomyelitis of Garré is a rare condition that occurs most commonly in tubular bones and the mandible. Its nontypical symptoms, low morbidity, and insidious process make its diagnosis difficult at an early stage. In this article, we reported a case of chronic sclerosing osteomyelitis which occurred in flat bone. PATIENT CONCERNS: A 53-year-old man was diagnosed with rib sclerosing osteomyelitis of Garré who had an 8-year course of intermittent local pain and swelling, which radiated toward the left side of his chest wall. Chest computed tomography (CT) showed irregular sclerosis of the diaphysis of the 10th rib, with periosteal reaction and narrowing of the medullary cavity, and magnetic resonance imaging (MRI) showed T2 heterogeneous low-signal intensity over the 10th rib. DIAGNOSES: Based on the features of the clinical signs and radiography and biopsy of the lesion, diagnosis of rib sclerosing osteomyelitis of Garré was made. INTERVENTIONS: The patient was treated with surgical excision of a 10-cm-long lesion after failed conservative treatment. OUTCOMES: Postoperatively, the patient achieved good functional recovery at the 10-year follow-up. LESSONS: Rib sclerosing osteomyelitis of Garré is an unusual condition and represents a noninfective course in the rib with a low morbidity. The surgical management was successful in relieving the patient's symptom.
[Mh] Termos MeSH primário: Osteomielite/diagnóstico
Osteomielite/patologia
Costelas/patologia
[Mh] Termos MeSH secundário: Diáfises
Seres Humanos
Masculino
Meia-Idade
Osteomielite/cirurgia
Esclerose
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008692


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[PMID]:27771152
[Au] Autor:Bagan L; Leopoldo-Rodado M; Poveda-Roda R; Murillo-Cortes J; Diaz-Fernández JM; Bagan J
[Ad] Endereço:Universidad Europea de Valencia, Valencia, Spain.
[Ti] Título:Grade of sclerosis in the contralateral mandibular area in osteonecrosis of the jaws.
[So] Source:Int J Oral Maxillofac Surg;46(2):167-172, 2017 Feb.
[Is] ISSN:1399-0020
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to compare the grade of radiographic sclerosis between the area of osteonecrosis and the at-risk contralateral mandibular area without osteonecrosis. Three groups were studied: group 1 comprised 30 cases of medication-related osteonecrosis of the jaws (MRONJ); group 2 was the healthy contralateral area without osteonecrosis of the group 1 cases; group 3 comprised 30 healthy controls. ImageJ software was used to analyze the computed tomography images, and the grade of bone sclerosis was compared between the three groups. The grade of sclerosis was significantly higher in group 1 than in the other groups (P<0.05); the difference between groups 2 and 3 was not significant. Sclerosis was significantly greater in the area of bone necrosis than in the contralateral mandibular area in patients with MRONJ. No significant differences were found in the grade of sclerosis between the contralateral non-affected mandibular area of patients with MRONJ and the control patients.
[Mh] Termos MeSH primário: Osteonecrose da Arcada Osseodentária Associada a Difosfonatos/patologia
Doenças Mandibulares/patologia
[Mh] Termos MeSH secundário: Idoso
Osteonecrose da Arcada Osseodentária Associada a Difosfonatos/diagnóstico por imagem
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Doenças Mandibulares/diagnóstico por imagem
Esclerose
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29369193
[Au] Autor:Li Y; Meng X; Wang Y; Yang Y; Lu X
[Ad] Endereço:Department of Echocardiography, Heart Center.
[Ti] Título:Fibrosing mediastinitis with pulmonary hypertension as a complication of pulmonary vein stenosis: A case report and review of the literature.
[So] Source:Medicine (Baltimore);97(4):e9694, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Fibrosingmediastinitis (FM) is caused by a proliferation of fibrous tissue in the mediastinum encasing the mediastinal viscera that results in compression of mediastinal bronchovascular structures. Pulmonary hypertension (PH) is a severe complication of FM caused by extrinsic compression of pulmonary blood vessels. CASE PRESENTATION: Here, we present the case of a 47-year-old man who presented with a 10-year history of progressive hemoptysis and a 2-year history of shortness of breath, in whom a diagnosis of FM was made. Occlusion of the superior pulmonary veins was noted, with stenosis of the inferior pulmonary veins, leading to PH. Because the patient was a poor candidate for interventional catheterization, the preferred treatment for FM, his PH has been managed with diuretics, and he remains stable. CONCLUSIONS: FM is a serious, potentially life-threatening condition that is best managed in specialized centers.
[Mh] Termos MeSH primário: Hipertensão Pulmonar/etiologia
Mediastinite/etiologia
Esclerose/etiologia
Estenose de Veia Pulmonar/complicações
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009694


  4 / 6904 MEDLINE  
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Teixeira, Manoel Jacobsen
Texto completo SciELO Brasil
[PMID]:29236824
[Au] Autor:Flores JAC; Sanders FH; Figueiredo EG; Teixeira MJ
[Ad] Endereço:Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Instituto de Psiquiatria, Divisão de Neurocirurgia Funcional, São Paulo SP, Brasil.
[Ti] Título:Transtemporal amygdalohippocampectomy: a novel minimally-invasive technique with optimal clinical results and low cost.
[So] Source:Arq Neuropsiquiatr;75(11):801-808, 2017 Nov.
[Is] ISSN:1678-4227
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Mesial temporal sclerosis creates a focal epileptic syndrome that usually requires surgical resection of mesial temporal structures. OBJECTIVE: To describe a novel operative technique for treatment of temporal lobe epilepsy and its clinical results. METHODS: Prospective case-series at a single institution, performed by a single surgeon, from 2006 to 2012. A total of 120 patients were submitted to minimally-invasive keyhole transtemporal amygdalohippocampectomy. RESULTS: Of the patients, 55% were male, and 85% had a right-sided disease. The first 70 surgeries had a mean surgical time of 2.51 hours, and the last 50 surgeries had a mean surgical time of 1.62 hours. There was 3.3% morbidity, and 5% mild temporal muscle atrophy. There was no visual field impairment. On the Engel Outcome Scale at the two-year follow-up, 71% of the patients were Class I, 21% were Class II, and 6% were Class III. CONCLUSION: This novel technique is feasible and reproducible, with optimal clinical results.
[Mh] Termos MeSH primário: Tonsila do Cerebelo/cirurgia
Epilepsia do Lobo Temporal/cirurgia
Hipocampo/cirurgia
Esclerose/cirurgia
Lobo Temporal/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Feminino
Seres Humanos
Masculino
Meia-Idade
Procedimentos Cirúrgicos Minimamente Invasivos/economia
Procedimentos Cirúrgicos Minimamente Invasivos/métodos
Procedimentos Neurocirúrgicos/economia
Procedimentos Neurocirúrgicos/métodos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE


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[PMID]:29244830
[Au] Autor:Butterfield RJ; Dunn DM; Hu Y; Johnson K; Bönnemann CG; Weiss RB
[Ad] Endereço:University of Utah, Departments of Pediatrics and Neurology, Salt Lake City, Utah, United States of America.
[Ti] Título:Transcriptome profiling identifies regulators of pathogenesis in collagen VI related muscular dystrophy.
[So] Source:PLoS One;12(12):e0189664, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The collagen VI related muscular dystrophies (COL6-RD), Ullrich congenital muscular dystrophy (UCMD) and Bethlem myopathy (BM) are among the most common congenital muscular dystrophies and are characterized by distal joint laxity and a combination of distal and proximal joint contractures. Inheritance can be dominant negative (DN) or recessive depending on the type and location of the mutation. DN mutations allow incorporation of abnormal chains into secreted tetramers and are the most commonly identified mutation type in COL6-RD. Null alleles (nonsense, frameshift, and large deletions) do not allow incorporation of abnormal chains and act recessively. To better define the pathways disrupted by mutations in collagen VI, we have used a transcriptional profiling approach with RNA-Seq to identify differentially expressed genes in COL6-RD individuals from controls. METHODS: RNA-Seq allows precise detection of all expressed transcripts in a sample and provides a tool for quantification of expression data on a genomic scale. We have used RNA-Seq to identify differentially expressed genes in cultured dermal fibroblasts from 13 COL6-RD individuals (8 dominant negative and 5 null) and 6 controls. To better assess the transcriptional changes induced by abnormal collagen VI in the extracellular matrix (ECM); we compared transcriptional profiles from subjects with DN mutations and subjects with null mutations to transcriptional profiles from controls. RESULTS: Differentially expressed transcripts between COL6-RD and control fibroblasts include upregulation of ECM components and downregulation of factors controlling matrix remodeling and repair. DN and null samples are differentiated by downregulation of genes involved with DNA replication and repair in null samples. CONCLUSIONS: Differentially expressed genes identified here may help identify new targets for development of therapies and biomarkers to assess the efficacy of treatments.
[Mh] Termos MeSH primário: Colágeno Tipo VI/genética
Contratura/genética
Distrofias Musculares/congênito
Esclerose/genética
Transcriptoma/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Contratura/diagnóstico
Contratura/fisiopatologia
Matriz Extracelular/genética
Feminino
Fibroblastos/metabolismo
Fibroblastos/patologia
Perfilação da Expressão Gênica/métodos
Regulação da Expressão Gênica
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Lactente
Masculino
Distrofias Musculares/diagnóstico
Distrofias Musculares/genética
Distrofias Musculares/fisiopatologia
Mutação
Esclerose/diagnóstico
Esclerose/fisiopatologia
Deleção de Sequência/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Col6a1 protein, human); 0 (Collagen Type VI)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189664


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[PMID]:28982854
[Au] Autor:Park CK; Kim HS
[Ad] Endereço:Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
[Ti] Título:Clinicopathological Characteristics of Ovarian Sclerosing Stromal Tumor with an Emphasis on TFE3 Overexpression.
[So] Source:Anticancer Res;37(10):5441-5447, 2017 10.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:A sclerosing stromal tumor is a very rare benign sex cord-stromal tumor of the ovary. Because its clinical presentation and imaging findings are similar to those of borderline or malignant epithelial tumors and other sex cord-stromal tumors, accurate preoperative clinical diagnosis can be difficult. The aim of this study was to analyze the clinicopathological characteristics of SSTs and examine the immunohistochemical expression TFE3, which has not been studied in SSTs. Our study cohort consisted of 9 patients diagnosed as having SST; the median age was 36 years. Radiologically, SSTs presented as multiseptated cystic masses, mixed echoic masses, pseudolobular masses, solid pelvic masses, or uterine subserosal nodules. In 4 of the 9 cases, the preoperative clinical impression was a borderline or malignant ovarian tumor. SSTs displayed the following histopathological features: 1) relatively well-circumscribed cellular nodules that were randomly distributed in the fibrous or edematous stroma; 2) a characteristic alternating pattern of hypercellular and hypocellular areas; 3) a hemangiopericytoma-like vascular growth pattern in the cellular nodules; 4) bland-looking spindle-shaped cells and round or polygonal cells densely clustered around blood vessels; and 5) red blood cell-containing intracytoplasmic vacuole-like spaces in the tumor cell cytoplasm, possibly indicating epithelioid hemangioendothelioma. Immunohistochemically, the tumor cells exhibited diffuse and moderate-to-strong TFE3 expression in 7 of the 9 SSTs. TFE3 was strongly expressed in the nuclei of round or polygonal cells and lutein cells. In contrast, neither luteinized thecomas nor fibromas appreciably expressed TFE3. In summary, our study describes characteristic histopathological features that may be useful for differentiating SSTs from other sex-cord stromal tumors and demonstrates for the first time that SSTs show strong TFE3 expression. Further investigations are necessary to clarify the role of TFE3 in the development of SSTs.
[Mh] Termos MeSH primário: Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/análise
Biomarcadores Tumorais/análise
Neoplasias Ovarianas/química
Tumores do Estroma Gonadal e dos Cordões Sexuais/química
Células Estromais/química
[Mh] Termos MeSH secundário: Adulto
Biópsia
Feminino
Seres Humanos
Imuno-Histoquímica
Meia-Idade
Neoplasias Ovarianas/patologia
Esclerose
Tumores do Estroma Gonadal e dos Cordões Sexuais/patologia
Células Estromais/patologia
Carga Tumoral
Regulação para Cima
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors); 0 (Biomarkers, Tumor); 0 (TFE3 protein, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


  7 / 6904 MEDLINE  
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[PMID]:28857179
[Au] Autor:Androsova G; Krause R; Borghei M; Wassenaar M; Auce P; Avbersek A; Becker F; Berghuis B; Campbell E; Coppola A; Francis B; Wolking S; Cavalleri GL; Craig J; Delanty N; Koeleman BPC; Kunz WS; Lerche H; Marson AG; Sander JW; Sills GJ; Striano P; Zara F; Sisodiya SM; Depondt C; EpiPGX Consortium
[Ad] Endereço:Luxembourg Center for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
[Ti] Título:Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis.
[So] Source:Epilepsia;58(10):1734-1741, 2017 Oct.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a common epilepsy syndrome that is often poorly controlled by antiepileptic drug (AED) treatment. Comparative AED effectiveness studies in this condition are lacking. We report retention, efficacy, and tolerability in a cohort of patients with MTLE-HS. METHODS: Clinical data were collected from a European database of patients with epilepsy. We estimated retention, 12-month seizure freedom, and adverse drug reaction (ADR) rates for the 10 most commonly used AEDs in patients with MTLE-HS. RESULTS: Seven hundred sixty-seven patients with a total of 3,249 AED trials were included. The highest 12-month retention rates were observed with carbamazepine (85.9%), valproate (85%), and clobazam (79%). Twelve-month seizure freedom rates varied from 1.2% for gabapentin and vigabatrin to 11% for carbamazepine. Response rates were highest for AEDs that were prescribed as initial treatment and lowest for AEDs that were used in a third or higher instance. ADRs were reported in 47.6% of patients, with the highest rates observed with oxcarbazepine (35.7%), topiramate (30.9%), and pregabalin (27.4%), and the lowest rates with clobazam (6.5%), gabapentin (8.9%), and lamotrigine (16.6%). The most commonly reported ADRs were lethargy and drowsiness, dizziness, vertigo and ataxia, and blurred vision and diplopia. SIGNIFICANCE: Our results did not demonstrate any clear advantage of newer versus older AEDs. Our results provide useful insights into AED retention, efficacy, and ADR rates in patients with MTLE-HS.
[Mh] Termos MeSH primário: Anticonvulsivantes/uso terapêutico
Epilepsia do Lobo Temporal/tratamento farmacológico
Hipocampo/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Aminas/uso terapêutico
Ataxia/induzido quimicamente
Benzodiazepinas/uso terapêutico
Carbamazepina/análogos & derivados
Carbamazepina/uso terapêutico
Ácidos Cicloexanocarboxílicos/uso terapêutico
Bases de Dados Factuais
Diplopia/induzido quimicamente
Tontura/induzido quimicamente
Epilepsia do Lobo Temporal/patologia
Epilepsia do Lobo Temporal/fisiopatologia
Feminino
Frutose/análogos & derivados
Frutose/uso terapêutico
Seres Humanos
Letargia/induzido quimicamente
Masculino
Meia-Idade
Pregabalina/uso terapêutico
Estudos Retrospectivos
Esclerose
Resultado do Tratamento
Triazinas/uso terapêutico
Ácido Valproico/uso terapêutico
Vertigem/induzido quimicamente
Vigabatrina/uso terapêutico
Transtornos da Visão/induzido quimicamente
Adulto Jovem
Ácido gama-Aminobutírico/uso terapêutico
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amines); 0 (Anticonvulsants); 0 (Cyclohexanecarboxylic Acids); 0 (Triazines); 0H73WJJ391 (topiramate); 12794-10-4 (Benzodiazepines); 2MRO291B4U (clobazam); 30237-26-4 (Fructose); 33CM23913M (Carbamazepine); 55JG375S6M (Pregabalin); 56-12-2 (gamma-Aminobutyric Acid); 614OI1Z5WI (Valproic Acid); 6CW7F3G59X (gabapentin); GR120KRT6K (Vigabatrin); U3H27498KS (lamotrigine); VZI5B1W380 (oxcarbazepine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13871


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[PMID]:28815576
[Au] Autor:Bencurova P; Baloun J; Musilova K; Radova L; Tichy B; Pail M; Zeman M; Brichtova E; Hermanova M; Pospisilova S; Mraz M; Brazdil M
[Ad] Endereço:Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
[Ti] Título:MicroRNA and mesial temporal lobe epilepsy with hippocampal sclerosis: Whole miRNome profiling of human hippocampus.
[So] Source:Epilepsia;58(10):1782-1793, 2017 Oct.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Mesial temporal lobe epilepsy (mTLE) is a severe neurological disorder characterized by recurrent seizures. mTLE is frequently accompanied by neurodegeneration in the hippocampus resulting in hippocampal sclerosis (HS), the most common morphological correlate of drug resistance in mTLE patients. Incomplete knowledge of pathological changes in mTLE+HS complicates its therapy. The pathological mechanism underlying mTLE+HS may involve abnormal gene expression regulation, including posttranscriptional networks involving microRNAs (miRNAs). miRNA expression deregulation has been reported in various disorders, including epilepsy. However, the miRNA profile of mTLE+HS is not completely known and needs to be addressed. METHODS: Here, we have focused on hippocampal miRNA profiling in 33 mTLE+HS patients and nine postmortem controls to reveal abnormally expressed miRNAs. In this study, we significantly reduced technology-related bias (the most common source of false positivity in miRNA profiling data) by combining two different miRNA profiling methods, namely next generation sequencing and miRNA-specific quantitative real-time polymerase chain reaction. RESULTS: These methods combined have identified and validated 20 miRNAs with altered expression in the human epileptic hippocampus; 19 miRNAs were up-regulated and one down-regulated in mTLE+HS patients. Nine of these miRNAs have not been previously associated with epilepsy, and 19 aberrantly expressed miRNAs potentially regulate the targets and pathways linked with epilepsy (such as potassium channels, γ-aminobutyric acid, neurotrophin signaling, and axon guidance). SIGNIFICANCE: This study extends current knowledge of miRNA-mediated gene expression regulation in mTLE+HS by identifying miRNAs with altered expression in mTLE+HS, including nine novel abnormally expressed miRNAs and their putative targets. These observations further encourage the potential of microRNA-based biomarkers or therapies.
[Mh] Termos MeSH primário: Epilepsia do Lobo Temporal/genética
Regulação da Expressão Gênica
Hipocampo/patologia
MicroRNAs/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Simulação por Computador
Regulação para Baixo
Epilepsia do Lobo Temporal/metabolismo
Epilepsia do Lobo Temporal/patologia
Epilepsia do Lobo Temporal/cirurgia
Feminino
Perfilação da Expressão Gênica
Sequenciamento de Nucleotídeos em Larga Escala
Hipocampo/metabolismo
Hipocampo/cirurgia
Seres Humanos
Masculino
Meia-Idade
Reação em Cadeia da Polimerase em Tempo Real
Esclerose
Análise de Sequência de RNA
Regulação para Cima
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MicroRNAs)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13870


  9 / 6904 MEDLINE  
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[PMID]:28797398
[Au] Autor:Patterson J; Graham D; George A; Will M; Sutter D
[Ad] Endereço:Department of Pediatrics, San Antonio Military Medical Center, JBSA Fort Sam Houston, TX.
[Ti] Título:Right Middle Lobe Collapse and Pleural Effusion in an 18-Year-Old Man.
[So] Source:Chest;152(2):e33-e38, 2017 Aug.
[Is] ISSN:1931-3543
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An 18-year-old African American male subject presented to an acute care clinic with 3 days of productive cough, chills, pleuritic right chest pain, sore throat with hoarseness, congestion, and intermittent shortness of breath. He recently relocated to Texas from Georgia to undergo basic military training. He denied any other recent travel or contact with persons with pulmonary TB or other respiratory illnesses. His medical history was significant for glucose-6-phosphate dehydrogenase deficiency and sickle cell trait.
[Mh] Termos MeSH primário: Histoplasmose/diagnóstico
Pneumopatias Fúngicas/diagnóstico
Mediastinite/microbiologia
Derrame Pleural/microbiologia
Atelectasia Pulmonar/microbiologia
Esclerose/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Histoplasma
Histoplasmose/diagnóstico por imagem
Seres Humanos
Pneumopatias Fúngicas/diagnóstico por imagem
Masculino
Mediastinite/diagnóstico por imagem
Derrame Pleural/diagnóstico por imagem
Atelectasia Pulmonar/diagnóstico por imagem
Esclerose/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE


  10 / 6904 MEDLINE  
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[PMID]:28656696
[Au] Autor:Mathon B; Bielle F; Samson S; Plaisant O; Dupont S; Bertrand A; Miles R; Nguyen-Michel VH; Lambrecq V; Calderon-Garcidueñas AL; Duyckaerts C; Carpentier A; Baulac M; Cornu P; Adam C; Clemenceau S; Navarro V
[Ad] Endereço:Department of Neurosurgery, AP-HP, La Pitié-Salpêtrière-Charles Foix University Hospital, Paris, France.
[Ti] Título:Predictive factors of long-term outcomes of surgery for mesial temporal lobe epilepsy associated with hippocampal sclerosis.
[So] Source:Epilepsia;58(8):1473-1485, 2017 Aug.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The reasons for failure of surgical treatment for mesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis (HS) remain unclear. This retrospective study analyzed seizure, cognitive, and psychiatric outcomes, searching for factors associated with seizure relapse or cognitive and psychiatric deterioration after MTLE-HS surgery. METHODS: Seizure, cognitive, and psychiatric outcomes were reviewed after 389 surgeries performed between 1990 and 2015 on patients aged 15-67 years at a tertiary center. Three surgical approaches were used: anterior temporal lobectomy (ATL; n = 209), transcortical selective amygdalohippocampectomy (SAH; n = 144), and transsylvian SAH (n = 36). RESULTS: With an average follow-up of 8.7 years (range = 1.0-25.2), seizure outcome was classified as Engel I in 83.7% and Engel Ia in 57.1% of patients. The histological classification of HS was type 1 for 75.3% of patients, type 2 for 18.7%, and type 3 for 1.2%. Two factors were significantly associated with seizure recurrence: past history of status epilepticus and preoperative intracranial electroencephalographic recording. In contrast, neither HS type, the presence of a dual pathology, nor surgical approach was associated with seizure outcome. Risk of cognitive impairment was 3.12 (95% confidence interval = 1.27-7.70), greater in patients after ATL than in patients after transcortical SAH. A presurgical psychiatric history and postoperative cognitive impairment were associated with poor psychiatric outcome. SIGNIFICANCE: The SAH and ATL approaches have similar beneficial effects on seizure control, whereas transcortical SAH tends to minimize cognitive deterioration after surgery. Variation in postsurgical outcome with the class of HS should be investigated further.
[Mh] Termos MeSH primário: Lobectomia Temporal Anterior/métodos
Epilepsia do Lobo Temporal/complicações
Epilepsia do Lobo Temporal/cirurgia
Hipocampo/patologia
Resultado do Tratamento
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Transtornos Cognitivos/etiologia
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Meia-Idade
Complicações Pós-Operatórias/diagnóstico
Complicações Pós-Operatórias/etiologia
Valor Preditivo dos Testes
Estudos Retrospectivos
Esclerose/etiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13831



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