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  1 / 9822 MEDLINE  
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[PMID]:29505517
[Au] Autor:Abulimiti A; Husaiyin A; Sailai Y
[Ad] Endereço:Department of General Surgery, First Affiliated Hospital of Xinjiang Medical University, Urimqi, China.
[Ti] Título:Evaluation of HVHF for the treatment of severe acute pancreatitis accompanying MODS.
[So] Source:Medicine (Baltimore);97(1):e9417, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Systemic inflammatory response syndrome (SIRS) prevention is key to severe acute pancreatitis (SAP) treatment and the assessment of high-volume hemofiltration (HVHF) for treating SAP accompanying multiple organ dysfunction syndromes.In this prospective controlled study, 40 SAP patients were divided into 2 groups: control (n = 22, treated with fasting, decompression, and intravenous somatostatin) and HVHF (n = 18, HVHF administration in addition to the treatment in the control group) groups; and were assessed for serum and urine amylase, WBC, C-reactive protein (CRP), and hepatic and renal functions. Vital signs and abdominal symptoms were recorded, and complications and mortality were analyzed.APACHE II scores in the HVHF group were significantly lower than in the control group at 3 and 7 days (6.3 ±â€Š1.7 vs 9.2 ±â€Š2.1 and 3.3 ±â€Š0.8 vs 6.2 ±â€Š1.7, respectively). Compared with controls, serum, and urine amylase, WBC, CRP, and organ functions significantly improved after HVHF treatment. Meanwhile, mortality (16.7% vs 31.8%) and complication (11.1% vs 40.9%) rates were significantly reduced.The other clinical parameters were significantly ameliorated by HVHF. HVHF rapidly reduces abdominal symptoms and improves prognosis, reducing mortality in SAP patients; and is likely through systemic inflammatory response syndrome attenuation in the early disease stage.
[Mh] Termos MeSH primário: Hemofiltração/estatística & dados numéricos
Insuficiência de Múltiplos Órgãos/etiologia
Pancreatite/terapia
[Mh] Termos MeSH secundário: APACHE
Adulto
Idoso
Amilases/sangue
Amilases/urina
Nitrogênio da Ureia Sanguínea
Proteína C-Reativa/metabolismo
Feminino
Seres Humanos
Contagem de Leucócitos
Testes de Função Hepática
Masculino
Meia-Idade
Insuficiência de Múltiplos Órgãos/sangue
Insuficiência de Múltiplos Órgãos/urina
Pancreatite/sangue
Pancreatite/complicações
Pancreatite/urina
Estudos Prospectivos
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
9007-41-4 (C-Reactive Protein); EC 3.2.1.- (Amylases)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180306
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009417


  2 / 9822 MEDLINE  
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[PMID]:29489643
[Au] Autor:Lei Y; Zheng MH; Huang W; Zhang J; Lu Y
[Ad] Endereço:Department of Emergency Medicine.
[Ti] Título:Wet beriberi with multiple organ failure remarkably reversed by thiamine administration: A case report and literature review.
[So] Source:Medicine (Baltimore);97(9):e0010, 2018 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Circulatory failure, especially with low systemic vascular resistance (SVR), as observed in septic shock, thyrotoxicosis, and anemia, is a particular pattern that should suggest thiamine (vitamin B1) deficiency. The clinical picture of wet beriberi secondary to thiamine deficiency only demonstrates non-specific clinical manifestations. For a diagnosis of wet beriberi, medical history is very important. Interestingly, imprisonment was also found to be related to thiamine deficiency. This article presents a rare case of wet beriberi associated with multiple organ failure (MOF) in a prison patient with years of heavy alcohol consumption. PATIENT CONCERNS: The patient reported repetitive symptoms of nausea, vomiting, respiratory distress, and palpitations for a period of 1 month; dyspnea and edema for 5 days; and decreased blood pressure and urine volume for 2 days. DIAGNOSES: The heart failure patient had a history of dietary deficiency. Right heart catheterization showed high cardiac output (CO) and low SVR. Measurement of serum thiamine concentration was low. The most important factor was that the hemodynamic indices were remarkably reversed by thiamine administration. INTERVENTIONS: The patient started treatment with thiamine (100 mg) by intramuscular injection, together with basic supportive care. OUTCOMES: The hemodynamic indices improved within 12 hours after thiamine administration. Echocardiographic examinations revealed right ventricular function improvement within a few days, which were normal within a month. LESSONS: A diagnosis of wet beriberi should be considered for a prison patient who has unexplained heart failure, lactic acidosis, and/or MOF. Moreover, the patient should be empirically given thiamine administration without delay.
[Mh] Termos MeSH primário: Beriberi/complicações
Beriberi/tratamento farmacológico
Insuficiência de Múltiplos Órgãos/complicações
Insuficiência de Múltiplos Órgãos/tratamento farmacológico
Tiamina/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Alcoolismo/complicações
Beriberi/etiologia
Beriberi/fisiopatologia
Débito Cardíaco
Seres Humanos
Masculino
Insuficiência de Múltiplos Órgãos/etiologia
Insuficiência de Múltiplos Órgãos/fisiopatologia
Prisioneiros
Deficiência de Tiamina/complicações
Deficiência de Tiamina/tratamento farmacológico
Resistência Vascular
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
X66NSO3N35 (Thiamine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180301
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000010010


  3 / 9822 MEDLINE  
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[PMID]:28459157
[Au] Autor:Ozer EK; Goktas MT; Kilinc I; Toker A; Bariskaner H; Ugurluoglu C; Iskit AB
[Ad] Endereço:a Department of Pharmacology, Faculty of Medicine, Selcuk University, Konya, Turkey.
[Ti] Título:Infliximab alleviates the mortality, mesenteric hypoperfusion, aortic dysfunction, and multiple organ damage in septic rats.
[So] Source:Can J Physiol Pharmacol;95(7):866-872, 2017 Jul.
[Is] ISSN:1205-7541
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Tumor necrosis factor-alpha (TNF-α) is a pivotal mediator that triggers inflammatory process, oxidative stress, and multiple organ injury in sepsis. We investigated the effects of infliximab on survival, mesenteric artery blood flow (MBF), vascular reactivity, and oxidative and inflammatory injuries in cecal ligation and puncture (CLP)-induced sepsis. Wistar rats were divided into Sham, CLP, Sham+infliximab, and CLP+infliximab subgroups. Twenty-four hours before the operations, rats were injected intraperitoneally with infliximab (7 mg/kg) or vehicle (saline; 1 mL/kg). Twenty hours after the operations, MBF and phenylephrine responses of isolated aortic rings were measured. Tissue damages were examined biochemically and histopathologically. Furthermore, survival rates were monitored throughout 96 h. Infliximab improved survival, mesenteric perfusion, and aortic function after CLP. Increases of serum AST, ALT, LDH, BUN, Cr, and inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6) induced by CLP were blocked by infliximab. Infliximab prevented malondialdehyde elevations in septic liver, lung, spleen, and kidney tissues, as well as glutathione reductions in septic liver, spleen, and kidney tissues. Protective effects of infliximab on multiple organ damage were also observed histopathologically. Infliximab showed protective effects in sepsis due to its improvement effects on mesenteric perfusion, aortic function, and its anti-inflammatory and antioxidative effects.
[Mh] Termos MeSH primário: Aorta/efeitos dos fármacos
Circulação Sanguínea/efeitos dos fármacos
Infliximab/farmacologia
Mesentério/irrigação sanguínea
Insuficiência de Múltiplos Órgãos/complicações
Sepse/mortalidade
Sepse/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Aorta/fisiopatologia
Feminino
Interleucina-6/metabolismo
Contração Muscular/efeitos dos fármacos
Músculo Liso Vascular/efeitos dos fármacos
Músculo Liso Vascular/fisiopatologia
Ratos
Ratos Wistar
Sepse/complicações
Sepse/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-6); B72HH48FLU (Infliximab)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1139/cjpp-2016-0628


  4 / 9822 MEDLINE  
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[PMID]:29390336
[Au] Autor:Lovisari F; Terzi V; Lippi MG; Brioschi PR; Fumagalli R
[Ad] Endereço:Department of Anesthesia and Critical Care, ASST Grande Ospedale Metropolitano Niguarda. P.zza Ospedale Maggiore, Milan.
[Ti] Título:Hemophagocytic lymphohistiocytosis complicated by multiorgan failure: A case report.
[So] Source:Medicine (Baltimore);96(50):e9198, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: We present a case of hemophagocytic lymphohistiocytosis (HLH) with severe pulmonary complication and acute respiratory distress syndrome (ARDS) hospitalized in our intensive care unit (ICU) in 2014; distinctive trait of this case has been the challenging diagnosis, with a bone marrow biopsy always negative, the severe pulmonary complication with ARDS and severe pulmonary hypertension, and the ferritin temporal kinetics that precisely followed the clinical course of disease. PATIENT CONCERNS: A 32-year-old woman from the Philippines first diagnosed with upper airway infection, was subsequently hospitalized in infectious disease department and treated for community acquired pneumonia. DIAGNOSES: After clinical picture worsened with a profound respiratory insufficiency, the patient was intubated and transferred to our ICU. During this hospitalization, the clinical picture of fever, cutaneous rashes, lymphadenitis, hepatitis, leukopenia, anemia, hyperferritinemia, hypertriglyceridemia, high level of auto-antibodies, and low NK activity suggested an hemophagocytic lymphohistiocytosis syndrome, even if bone marrow biopsy was negative for hemophagocytosis. INTERVENTIONS: Immunosuppressive therapy with dexamethasone and etoposide was started, and the patient was discharged from ICU 4 months after admission. LESSONS: HLH is a rare disorder of the mononuclear phagocytic system, characterized by systemic proliferation of non- neoplastic histiocytes. The diagnosis is often challenging and not all of the diagnostic criteria may be present at the same time; this case shows how complex the diagnosis could be, how hematic ferritin levels could help in following the course of the disease, and the possibility of severe pulmonary complication either due to the disease itself and to possible sovra infections.
[Mh] Termos MeSH primário: Linfo-Histiocitose Hemofagocítica/complicações
Linfo-Histiocitose Hemofagocítica/diagnóstico
Insuficiência de Múltiplos Órgãos/diagnóstico
Insuficiência de Múltiplos Órgãos/etiologia
[Mh] Termos MeSH secundário: Adulto
Dexametasona/uso terapêutico
Diagnóstico Diferencial
Quimioterapia Combinada
Etoposídeo/uso terapêutico
Feminino
Glucocorticoides/uso terapêutico
Seres Humanos
Linfo-Histiocitose Hemofagocítica/tratamento farmacológico
Insuficiência de Múltiplos Órgãos/tratamento farmacológico
Inibidores da Topoisomerase II/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (Topoisomerase II Inhibitors); 6PLQ3CP4P3 (Etoposide); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009198


  5 / 9822 MEDLINE  
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[PMID]:28749818
[Au] Autor:Lehingue S; Rambaud R; Guervilly C; Adda M; Forel JM; Cassir N; Zandotti C; Hraiech S; Papazian L
[Ad] Endereço:Réanimation des Détresses Respiratoires et Infections Sévères, Aix-Marseille University, APHM, Hôpital Nord, Marseille, France.
[Ti] Título:Fatal Septic Shock Triggered by Donor Transmitted Varicella Zoster Virus Reinfection 3 Days After Lung Transplantation.
[So] Source:Transplantation;101(12):e351-e352, 2017 12.
[Is] ISSN:1534-6080
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Herpesvirus Humano 3/patogenicidade
Transplante de Pulmão/efeitos adversos
Pulmão/virologia
Insuficiência de Múltiplos Órgãos/virologia
Choque Séptico/virologia
Doadores de Tecidos
Infecção pelo Vírus da Varicela-Zoster/transmissão
Infecção pelo Vírus da Varicela-Zoster/virologia
[Mh] Termos MeSH secundário: Adulto
Evolução Fatal
Feminino
Seres Humanos
Masculino
Meia-Idade
Insuficiência de Múltiplos Órgãos/diagnóstico
Choque Séptico/diagnóstico
Infecção pelo Vírus da Varicela-Zoster/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1097/TP.0000000000001899


  6 / 9822 MEDLINE  
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[PMID]:29251990
[Au] Autor:Wang Y; Yin X; Yang F
[Ad] Endereço:Department of Critical Care Medicine, Weihai Central Hospital , Weihai, China .
[Ti] Título:Comprehensive Analysis of Gene Expression Profiles of Sepsis-Induced Multiorgan Failure Identified Its Valuable Biomarkers.
[So] Source:DNA Cell Biol;37(2):90-98, 2018 Feb.
[Is] ISSN:1557-7430
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sepsis is an inflammatory-related disease, and severe sepsis would induce multiorgan dysfunction, which is the most common cause of death of patients in noncoronary intensive care units. Progression of novel therapeutic strategies has proven to be of little impact on the mortality of severe sepsis, and unfortunately, its mechanisms still remain poorly understood. In this study, we analyzed gene expression profiles of severe sepsis with failure of lung, kidney, and liver for the identification of potential biomarkers. We first downloaded the gene expression profiles from the Gene Expression Omnibus and performed preprocessing of raw microarray data sets and identification of differential expression genes (DEGs) through the R programming software; then, significantly enriched functions of DEGs in lung, kidney, and liver failure sepsis samples were obtained from the Database for Annotation, Visualization, and Integrated Discovery; finally, protein-protein interaction network was constructed for DEGs based on the STRING database, and network modules were also obtained through the MCODE cluster method. As a result, lung failure sepsis has the highest number of DEGs of 859, whereas the number of DEGs in kidney and liver failure sepsis samples is 178 and 175, respectively. In addition, 17 overlaps were obtained among the three lists of DEGs. Biological processes related to immune and inflammatory response were found to be significantly enriched in DEGs. Network and module analysis identified four gene clusters in which all or most of genes were upregulated. The expression changes of Icam1 and Socs3 were further validated through quantitative PCR analysis. This study should shed light on the development of sepsis and provide potential therapeutic targets for sepsis-induced multiorgan failure.
[Mh] Termos MeSH primário: Perfilação da Expressão Gênica
Insuficiência de Múltiplos Órgãos/metabolismo
Sepse/metabolismo
[Mh] Termos MeSH secundário: Animais
Biomarcadores/metabolismo
Redes Reguladoras de Genes
Camundongos
MicroRNAs/genética
MicroRNAs/metabolismo
Insuficiência de Múltiplos Órgãos/genética
Insuficiência de Múltiplos Órgãos/microbiologia
Mapas de Interação de Proteínas
Interferência de RNA
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Sepse/complicações
Sepse/genética
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (MicroRNAs); 0 (RNA, Messenger)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1089/dna.2017.3944


  7 / 9822 MEDLINE  
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[PMID]:29419665
[Au] Autor:Lago AF; de Oliveira AS; de Souza HCD; da Silva JS; Basile-Filho A; Gastaldi AC
[Ad] Endereço:Department of Physiotherapy, Rehabilitation and Functional Performance Post Graduation Program.
[Ti] Título:The effects of physical therapy with neuromuscular electrical stimulation in patients with septic shock: Study protocol for a randomized cross-over design.
[So] Source:Medicine (Baltimore);97(6):e9736, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Septic shock is a potentially fatal organ dysfunction caused by an imbalance of the host response to infection. The changes in microcirculation during sepsis can be explained by the alterations in the endothelial barrier function. Endothelial progenitor cells (EPCs) are a potential recovery index of endothelial function and it an increase in response to neuromuscular electrical stimulation (NMES) was demonstrated. Therefore, the objective of this study is to investigate the effects of NMES in patients with septic shock. METHODS AND ANALYSIS: It is a study protocol for a randomized cross-over design in an intensive care unit of a tertiary University hospital. Thirty-one patients aged 18 to 65 years. The study will be divided in 2 phases: the phase one will be held in the first 72 hours of septic shock and the phase two after 3 days of first assessment. Patients will be randomly selected to the intervention protocol (decubitus position with the limbs raised and NMES) and control protocol (decubitus position with the limbs raised without NMES). After this procedure, the patients will be allocated in group 1 (intervention and control protocol) or group 2 (control and intervention protocol) with a wash-out period of 4 to 6 hours between them. The main outcome is mobilization of EPCs. The secondary outcome is metabolic and hemodynamic data. A linear mixed model will be used for analysis of dependent variables and estimated values of the mean of the differences of each effect.
[Mh] Termos MeSH primário: Células Progenitoras Endoteliais/fisiologia
Insuficiência de Múltiplos Órgãos/prevenção & controle
Choque Séptico/terapia
Estimulação Elétrica Nervosa Transcutânea/métodos
[Mh] Termos MeSH secundário: Adulto
Cuidados Críticos/métodos
Estudos Cross-Over
Feminino
Seres Humanos
Masculino
Microcirculação/fisiologia
Meia-Idade
Insuficiência de Múltiplos Órgãos/etiologia
Avaliação de Resultados (Cuidados de Saúde)
Projetos de Pesquisa
Choque Séptico/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009736


  8 / 9822 MEDLINE  
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[PMID]:29297645
[Au] Autor:Yaroustovsky MB; Abramyan MV; Krotenko NP; Komardina EV
[Ti] Título:Methods of Molecular Transfusion in the Intensive Therapy of Critical States.
[So] Source:Vestn Ross Akad Med Nauk;71(4):281-7, 2016.
[Is] ISSN:0869-6047
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:Development of extracorporeal blood purification acquires greater significance in the intensive care of multiple organ failures (MOF) with all the pathophysiological aspects of its constituent parts. MOF are the main cause of mortality among critically ill patients and treatment of these patients require significant investment. The purpose of the implementation of extracorporeal blood correction techniques today is multiple organ support therapy (MOST). Early extracorporeal therapy is used only in the treatment of renal failure. Today extracorporeal techniques are increasingly being used to replace the functions of various organs and systems. MOST includes diffusion, convection, filtration, sorption, apheresis methodic. They affect the molecular and electrolyte composition of blood, allow to correct, repair, replace, and maintain homeostasis in severe multiorgan dysfunction. Extracorporeal new molecular technologies have been successfully applied in the intensive care of severe heart and respiratory failure, acute kidney injury and acute hepatic dysfunction, in the treatment of severe sepsis, metabolic disorders, the correction of immune imbalance.
[Mh] Termos MeSH primário: Hemofiltração/métodos
Hemoperfusão/métodos
Insuficiência de Múltiplos Órgãos/terapia
Plasmaferese/métodos
[Mh] Termos MeSH secundário: Cuidados Críticos/métodos
Cuidados Críticos/tendências
Estado Terminal/terapia
Seres Humanos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.15690/vramn680


  9 / 9822 MEDLINE  
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[PMID]:29307884
[Au] Autor:Dumancas CY; Reyes HAG; Cosico J; Savadkar A; Lah S
[Ad] Endereço:Department of Medicine, New York Medical College, Metropolitan Hospital Center, New York, NY, USA.
[Ti] Título:Streptococcus pneumoniae-Related Hemophagocytic Lymphohistiocytosis Treated with IVIG and Steroids.
[So] Source:Am J Case Rep;19:25-28, 2018 Jan 08.
[Is] ISSN:1941-5923
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening condition that has a poor prognosis due to the ensuing cytokine storm leading to severe organ damage. Current treatment guidelines suggest using a combination of steroid- and etoposide-based chemotherapy. CASE REPORT The authors present a case of a 41-year-old African-American female who presented with symptoms of foodborne illness and who developed multi-organ dysfunction. HLH was suspected because of poor response to broad-spectrum antibiotics with a constellation of findings, including cytopenia, hypofibrinogenemia, hypertriglyceridemia, and hyperferritinemia. Clinical improvement was noted after administration of intravenous immunoglobulin and dexamethasone while waiting for the soluble interleukin-2 receptor levels; therefore, chemotherapy was not administered.  CONCLUSIONS Despite the variable and poor prognosis of HLH, early treatment with steroids and immunosuppressive therapy is crucial to improving the survival rate. The inclusion of immunoglobulin therapy should be considered a treatment option for HLH.
[Mh] Termos MeSH primário: Dexametasona/administração & dosagem
Glucocorticoides/administração & dosagem
Imunoglobulinas Intravenosas/administração & dosagem
Fatores Imunológicos/administração & dosagem
Linfo-Histiocitose Hemofagocítica/microbiologia
Linfo-Histiocitose Hemofagocítica/terapia
Streptococcus pneumoniae/isolamento & purificação
[Mh] Termos MeSH secundário: Adulto
Antibacterianos/administração & dosagem
Índice de Massa Corporal
Diabetes Mellitus Tipo 2/complicações
Quimioterapia Combinada
Feminino
Seres Humanos
Linfo-Histiocitose Hemofagocítica/diagnóstico
Uso da Maconha/efeitos adversos
Insuficiência de Múltiplos Órgãos/tratamento farmacológico
Insuficiência de Múltiplos Órgãos/etiologia
Doenças Musculares/etiologia
Doenças Musculares/reabilitação
Transferência de Pacientes
Prognóstico
Fatores de Risco
Streptococcus pneumoniae/patogenicidade
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Glucocorticoids); 0 (Immunoglobulins, Intravenous); 0 (Immunologic Factors); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180109
[St] Status:MEDLINE


  10 / 9822 MEDLINE  
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[PMID]:28461212
[Au] Autor:Pillon M; Amigoni A; Contin A; Cattelan M; Carraro E; Campagnano E; Tumino M; Calore E; Marzollo A; Mainardi C; Boaro MP; Nizzero M; Pettenazzo A; Basso G; Messina C
[Ad] Endereço:Pediatric Hematology and Oncology, Department of Woman's and Child's Health, University-Hospital of Padua, Padua, Italy. Electronic address: marta.pillon@unipd.it.
[Ti] Título:Risk Factors and Outcomes Related to Pediatric Intensive Care Unit Admission after Hematopoietic Stem Cell Transplantation: A Single-Center Experience.
[So] Source:Biol Blood Marrow Transplant;23(8):1335-1341, 2017 Aug.
[Is] ISSN:1523-6536
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To describe incidence, causes, and outcomes related to pediatric intensive care unit (PICU) admission for patients undergoing hematopoietic stem cell transplantation (HSCT), we investigated the risk factors predisposing to PICU admission and prognostic factors in terms of patient survival. From October 1998 to April 2015, 496 children and young adults (0 to 23 years) underwent transplantation in the HSCT unit. Among them, 70 (14.1%) were admitted to PICU. The 3-year cumulative incidence of PICU admission was 14.3%. The main causes of PICU admission were respiratory failure (36%), multiple organ failure (16%), and septic shock (13%). The overall 90-day cumulative probability of survival after PICU admission was 34.3% (95% confidence interval, 24.8% to 47.4%). In multivariate analysis, risk factors predisposing to PICU admission were allogeneic HSCT (versus autologous HSCT, P = .030) and second or third HSCT (P = .018). Characteristics significantly associated with mortality were mismatched HSCT (P = .011), relapse of underlying disease before PICU admission (P < .001), acute respiratory distress syndrome at admission (P = .012), hepatic failure at admission (P = .021), and need for invasive ventilation during PICU course (P < .001). Our data indicate which patients have a high risk for PICU admission after HSCT and for dismal outcomes after PICU stay. These findings may provide support for the clinical decision-making process on the opportunity of PICU admission for severely compromised patients after HSCT.
[Mh] Termos MeSH primário: Cuidados Críticos
Transplante de Células-Tronco Hematopoéticas
Insuficiência de Múltiplos Órgãos
Admissão do Paciente
Insuficiência Respiratória
Choque Séptico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Aloenxertos
Criança
Pré-Escolar
Intervalo Livre de Doença
Feminino
Seres Humanos
Incidência
Lactente
Masculino
Insuficiência de Múltiplos Órgãos/etiologia
Insuficiência de Múltiplos Órgãos/mortalidade
Insuficiência de Múltiplos Órgãos/terapia
Insuficiência Respiratória/etiologia
Insuficiência Respiratória/mortalidade
Insuficiência Respiratória/terapia
Estudos Retrospectivos
Fatores de Risco
Choque Séptico/etiologia
Choque Séptico/mortalidade
Choque Séptico/terapia
Taxa de Sobrevida
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180125
[Lr] Data última revisão:
180125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE



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