Base de dados : MEDLINE
Pesquisa : C23.550.863 [Categoria DeCS]
Referências encontradas : 95 [refinar]
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[PMID]:28575072
[Au] Autor:Mangala Prasad V; Klose T; Rossmann MG
[Ad] Endereço:Department of Biological Sciences, 240 S. Martin Jischke Drive, Purdue University, West Lafayette, IN, United States of America.
[Ti] Título:Assembly, maturation and three-dimensional helical structure of the teratogenic rubella virus.
[So] Source:PLoS Pathog;13(6):e1006377, 2017 Jun.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Viral infections during pregnancy are a significant cause of infant morbidity and mortality. Of these, rubella virus infection is a well-substantiated example that leads to miscarriages or severe fetal defects. However, structural information about the rubella virus has been lacking due to the pleomorphic nature of the virions. Here we report a helical structure of rubella virions using cryo-electron tomography. Sub-tomogram averaging of the surface spikes established the relative positions of the viral glycoproteins, which differed from the earlier icosahedral models of the virus. Tomographic analyses of in vitro assembled nucleocapsids and virions provide a template for viral assembly. Comparisons of immature and mature virions show large rearrangements in the glycoproteins that may be essential for forming the infectious virions. These results present the first known example of a helical membrane-enveloped virus, while also providing a structural basis for its assembly and maturation pathway.
[Mh] Termos MeSH primário: Vírus da Rubéola/fisiologia
Rubéola (Sarampo Alemão)/virologia
Montagem de Vírus
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Tomografia com Microscopia Eletrônica
Seres Humanos
Nucleocapsídeo/genética
Nucleocapsídeo/metabolismo
Rubéola (Sarampo Alemão)/embriologia
Rubéola (Sarampo Alemão)/patologia
Vírus da Rubéola/química
Vírus da Rubéola/genética
Vírus da Rubéola/ultraestrutura
Teratogênese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006377


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[PMID]:28430131
[Au] Autor:Wang T; Wang C; Wu Q; Zheng K; Chen J; Lan Y; Qin Y; Mei W; Wang B
[Ad] Endereço:School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, Guangdong, China. wangtao1234@126.com.
[Ti] Título:Evaluation of Tanshinone IIA Developmental Toxicity in Zebrafish Embryos.
[So] Source:Molecules;22(4), 2017 Apr 21.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Tanshinone IIA (Tan-IIA) is derived from the dried roots of Bunge, a traditional Chinese medicine. Although has been applied for many years, the toxicity of the mono-constituent of , tanshinone IIA, is still understudied. This study evaluated the cardiotoxicity and developmental malformations of Tan-IIA by using zebrafish normal embryos and dechorionated embryos. After treatment with Tan-IIA in different concentrations for four-day periods, obvious pericardial edema, spinal curvature, and even missing tails were observed in zebrafish embryos. The LC values in the dechorionated embryo group at 72 h post-fertilization (hpf) and 96 hpf were 18.5 µM and 12.8 µM, respectively, and the teratogenicity was manifested at a concentration of about 1 µM. The main endpoints of teratogenicity were scoliosis, malformation of tail, and pericardium edema. Our findings displayed the potential cardiotoxicity and severe impact on the abnormal development of Tan-IIA in zebrafish embryo at high concentrations, which may help avoid the risk of its clinical application.
[Mh] Termos MeSH primário: Diterpenos Abietanos/toxicidade
Medicamentos de Ervas Chinesas/toxicidade
Embrião não Mamífero/efeitos dos fármacos
Teratogênese
[Mh] Termos MeSH secundário: Animais
Cardiotoxicidade
Diterpenos Abietanos/química
Medicamentos de Ervas Chinesas/química
Feminino
Concentração Inibidora 50
Masculino
Teratogênios/química
Teratogênios/toxicidade
Peixe-Zebra/embriologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes, Abietane); 0 (Drugs, Chinese Herbal); 0 (Teratogens); 03UUH3J385 (tanshinone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE


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[PMID]:28337452
[Au] Autor:Silva CR; Marinho KS; Silva TD; Ferreira DK; Aguiar GM; Martins MC; Santos KR; Aguiar Júnior FC; Santos NP; Pereira EC; Silva NH
[Ad] Endereço:Laboratory of Chemistry of Natural Products, Department of Biochemistry, UFPE, Recife, PE, Brazil.
[Ti] Título:Teratogenic Effect of Usnic Acid from Vainio during Organogenesis.
[So] Source:Biomed Res Int;2017:5948936, 2017.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Studies about toxicological potential of usnic acid are limited. This way, the vast majority of data available in the literature are related only to biological activities. This is the first study that aimed to evaluate the oral toxicity of usnic acid during the period of organogenesis. Females rats were distributed in the control groups, treated I and II, at doses of 15 and 25 mg/kg, administered by gavage during the 6° to 15° days of pregnancy. After 20 days the fetuses were removed and analyzed. A reduction in weight gain during pregnancy, increased resorption, reduction in the number of viable fetuses, and their body weight were observed. Morphological changes in the litter were visualized as exposure of the eye and atrophy of the limbs at the dose of 25 mg/kg. Histological analysis of the liver of the fetus showed reduction in the number of megakaryocytes between experimental groups and increase in the number of hepatocytes in a dose of 25 mg/kg. The experimental model used in this study reveals teratogenic effect of usnic acid in the period of organogenesis. Since this achievement, the importance of evaluating the toxic effects of natural substances is imperative, in order to elucidate the care in their indication as drug.
[Mh] Termos MeSH primário: Benzofuranos/administração & dosagem
Organogênese/efeitos dos fármacos
Teratogênese/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Ascomicetos/química
Benzofuranos/química
Peso Corporal/efeitos dos fármacos
Feminino
Desenvolvimento Fetal/efeitos dos fármacos
Feto/efeitos dos fármacos
Masculino
Tamanho do Órgão/efeitos dos fármacos
Gravidez
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzofurans); 0W584PFJ77 (usnic acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE
[do] DOI:10.1155/2017/5948936


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[PMID]:28264465
[Au] Autor:Lin YS; Lin TY; Wu JJ; Yao HT; Chang SL; Chao PM
[Ad] Endereço:Department of Nutrition, China Medical University, Taichung 404, Taiwan. chriscats211@yahoo.com.tw.
[Ti] Título:Peroxisome Proliferator-Activated Receptor α Activation Is Not the Main Contributor to Teratogenesis Elicited by Polar Compounds from Oxidized Frying Oil.
[So] Source:Int J Mol Sci;18(3), 2017 Feb 27.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:We previously reported that polar compounds (PO) in cooking oil are teratogenic and perturbed retinoic acid (RA) metabolism. Considering PO as a potent peroxisome proliferator-activated receptor α (PPARα) activator, this study aimed to investigate the role of PPARα in PO-induced teratogenesis and disturbance of RA metabolism. Female PPARα knockout or wild type mice were mated with males of the same genotype. Pregnant mice were fed a diet containing 10% fat from either fresh oil (FO) or PO from gestational day1 to day18, and killed at day18. The PO diet significantly increased the incidence of teratogenesis and fetal RA concentrations, regardless of genotype. Though PPARα deficiency disturbed maternal RA homeostasis, itself did not contribute to teratogenesis as long as FO diet was given. The mRNA profile of genes involved in RA metabolism was differentially affected by diet or genotype in mothers and fetuses. Based on hepatic mRNA levels of genes involved in xenobiotic metabolism, we inferred that PO not only activated PPARα, but also altered transactivity of other xenobiotic receptors. We concluded that PO-induced fetal anomalies and RA accumulation were independent of PPARα activation.
[Mh] Termos MeSH primário: Gorduras Insaturadas na Dieta/farmacologia
Óxidos
PPAR alfa/metabolismo
Teratogênese
[Mh] Termos MeSH secundário: Animais
Gorduras Insaturadas na Dieta/efeitos adversos
Feminino
Expressão Gênica
Camundongos
Camundongos Knockout
Óxidos/química
PPAR alfa/deficiência
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Reprodução/efeitos dos fármacos
Teratogênese/efeitos dos fármacos
Teratogênese/genética
Teratogênios/química
Teratogênios/farmacologia
Vitamina A/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats, Unsaturated); 0 (Oxides); 0 (PPAR alpha); 0 (RNA, Messenger); 0 (Teratogens); 11103-57-4 (Vitamin A)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE


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[PMID]:28257923
[Au] Autor:Jung JH; Ko J; Lee EH; Choi KM; Kim M; Yim UH; Lee JS; Shim WJ
[Ad] Endereço:Oil & POPs Research Group, Korea Institute of Ocean Science & Technology, Geoje 53201, Republic of Korea; Department of Marine Environmental Science, Korea University of Science and Technology, Daejeon 34113, Republic of Korea. Electronic address: jungjh@kiost.ac.kr.
[Ti] Título:RNA seq- and DEG-based comparison of developmental toxicity in fish embryos of two species exposed to Iranian heavy crude oil.
[So] Source:Comp Biochem Physiol C Toxicol Pharmacol;196:1-10, 2017 Jun.
[Is] ISSN:1532-0456
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To determine and compare the toxic effects of Iranian heavy crude oil (IHCO) on the embryonic development of two fish species, we examined transcriptome profiles using RNA-seq. The assembled contigs were 66,070 unigenes in olive flounder embryos and 76,498 unigenes in spotted seabass embryos. In the differential gene expression (DEG) profiles, olive flounder embryos showed different up- and down-regulated patterns than spotted seabass embryos in response to fresh IHCO (FIHCO) and weathered IHCO (WIHCO). In this work, we categorized DEG profiles into six pathways: ribosome, oxidative phosphorylation, Parkinson's disease, Alzheimer's disease, Huntington's disease, and cardiac muscle contraction, validating the expression patterns of 13 DEGs using real-time quantitative RT-PCR. The expression of the CYP1A, CYP1B1, and CYP1C1 genes in spotted seabass embryos was higher than in olive flounder embryos, whereas genes related to cell processing, development, and the immune system showed the opposite trend. Orthologous gene cluster analysis showed that olive flounder embryos were sensitive (fold change of genes with cutoff P<0.05) to both FIHCO and WIHCO, but spotted seabass embryos exhibited higher sensitivity to WIHCO than FIHCO, indicating that species-specific differences are likely to be reflected in population levels after oil spills. Overall, our study provides new insight on the different embryonic susceptibilities of two marine fish species to FIHCO and WIHCO and a better understanding of the underlying molecular mechanisms via RNA-seq and DEGs.
[Mh] Termos MeSH primário: Bass/embriologia
Linguado/embriologia
Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos
Morfogênese/efeitos dos fármacos
Petróleo/toxicidade
Teratogênese/efeitos dos fármacos
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Aquicultura
Bass/metabolismo
Análise por Conglomerados
Biologia Computacional
Família 1 do Citocromo P450/química
Família 1 do Citocromo P450/genética
Família 1 do Citocromo P450/metabolismo
Resistência a Medicamentos
Proteínas de Peixes/agonistas
Proteínas de Peixes/antagonistas & inibidores
Proteínas de Peixes/genética
Proteínas de Peixes/metabolismo
Linguado/metabolismo
Perfilação da Expressão Gênica
Ontologia Genética
Poluição por Petróleo/efeitos adversos
RNA Mensageiro/metabolismo
Distribuição Aleatória
República da Coreia
Especificidade da Espécie
Testes de Toxicidade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Fish Proteins); 0 (Petroleum); 0 (RNA, Messenger); 0 (Water Pollutants, Chemical); EC 1.14.14.1 (Cytochrome P450 Family 1)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE


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[PMID]:28254710
[Au] Autor:Hu S; Zhang H; Shen G; Yuan Z; Xu T; Ji R
[Ad] Endereço:Shanghai Academy of Environmental Sciences, Shanghai, 200233, China. Electronic address: husq@saes.sh.cn.
[Ti] Título:Effects of 17ß-estradiol and 17α-ethinylestradiol on the embryonic development of the clearhead icefish (Protosalanx hyalocranius).
[So] Source:Chemosphere;176:18-24, 2017 Jun.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Estrogenic effects of 17ß-estradiol (E2) and 17α-ethinylestradiol (EE2) on animals have been widely reported. The high sensitivity of fish in the early-life stages to xenobiotics can be exploited to evaluate the developmental effects of environmentally relevant levels of E2 and EE2. In this work, clearhead icefish (Protosalanx hyalocranius) embryos (blastula stage) were exposed to E2 or EE2 at concentrations between 0.05 ng/L and 1 mg/L. The toxicity endpoints of mortality, teratogenesis, and hatching retardation were evaluated. The results showed that continuous exposure of the fish embryos/larvae to higher concentrations of E2 and EE2 dramatically increased mortality after 17 days, when the hatching period started. An E2 concentration of 8 µg/L (day 16) and an EE2 concentration of at 0.2 mg/L (day 18) induced maximum teratogenesis rates of 30% and 35%, respectively. Embryos exposed to 0.2 mg E2 or EE2/L had a significantly retarded hatching time compared to the control. Thus, although environmentally relevant concentrations E2 and EE2 are not lethal for P. hyalocranius embryos or larvae, their ability to induce teratogenesis and hatching retardation merits concern.
[Mh] Termos MeSH primário: Embrião não Mamífero/efeitos dos fármacos
Estradiol/toxicidade
Etinilestradiol/toxicidade
Osmeriformes/embriologia
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
China
Embrião não Mamífero/anormalidades
Desenvolvimento Embrionário/efeitos dos fármacos
Monitoramento Ambiental
Larva/efeitos dos fármacos
Osmeriformes/anormalidades
Rios/química
Teratogênese/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); 423D2T571U (Ethinyl Estradiol); 4TI98Z838E (Estradiol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE


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[PMID]:28046103
[Au] Autor:Berres ME; Garic A; Flentke GR; Smith SM
[Ad] Endereço:Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
[Ti] Título:Transcriptome Profiling Identifies Ribosome Biogenesis as a Target of Alcohol Teratogenicity and Vulnerability during Early Embryogenesis.
[So] Source:PLoS One;12(1):e0169351, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fetal alcohol spectrum disorder (FASD) is a leading cause of neurodevelopmental disability. Individuals with FASD may exhibit a characteristic facial appearance that has diagnostic utility. The mechanism by which alcohol disrupts craniofacial development is incompletely understood, as are the genetic factors that can modify individual alcohol vulnerability. Using an established avian model, we characterized the cranial transcriptome in response to alcohol to inform the mechanism underlying these cells' vulnerability. Gallus gallus embryos having 3-6 somites were exposed to 52 mM alcohol and the cranial transcriptomes were sequenced thereafter. A total of 3422 genes had significantly differential expression. The KEGG pathways with the greatest enrichment of differentially expressed gene clusters were Ribosome (P = 1.2 x 10-17, 67 genes), Oxidative Phosphorylation (P = 4.8 x 10-12, 60 genes), RNA Polymerase (P = 2.2 x 10-3, 15 genes) and Spliceosome (P = 2.6 x 10-2, 39 genes). The preponderance of transcripts in these pathways were repressed in response to alcohol. These same gene clusters also had the greatest altered representation in our previous comparison of neural crest populations having differential vulnerability to alcohol-induced apoptosis. Comparison of differentially expressed genes in alcohol-exposed (3422) and untreated, alcohol-vulnerable (1201) transcriptomes identified 525 overlapping genes of which 257 have the same direction of transcriptional change. These included 36 ribosomal, 25 oxidative phosphorylation and 7 spliceosome genes. Using a functional approach in zebrafish, partial knockdown of ribosomal proteins zrpl11, zrpl5a, and zrps3a individually heightened vulnerability to alcohol-induced craniofacial deficits and increased apoptosis. In humans, haploinsufficiency of several of the identified ribosomal proteins are causative in craniofacial dysmorphologies such as Treacher Collins Syndrome and Diamond-Blackfan Anemia. This work suggests ribosome biogenesis may be a novel target mediating alcohol's damage to developing neural crest. Our findings are consistent with observations that gene-environment interactions contribute to vulnerability in FASD.
[Mh] Termos MeSH primário: Desenvolvimento Embrionário/efeitos dos fármacos
Etanol/toxicidade
Perfilação da Expressão Gênica
Biogênese de Organelas
Ribossomos/metabolismo
Teratogênese/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Embrião de Galinha
Embrião não Mamífero/efeitos dos fármacos
Embrião não Mamífero/metabolismo
Feminino
Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos
Técnicas de Silenciamento de Genes
Crista Neural/efeitos dos fármacos
Crista Neural/metabolismo
Reprodutibilidade dos Testes
Teratogênese/genética
Peixe-Zebra/embriologia
Peixe-Zebra/genética
Proteínas de Peixe-Zebra/genética
Proteínas de Peixe-Zebra/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Zebrafish Proteins); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170104
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0169351


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[PMID]:27717162
[Au] Autor:Lubinsky M
[Ad] Endereço:Washington Blvd Wauwatosa, Wisconsin.
[Ti] Título:Embryonic hypocellularity, blastogenetic malformations, and fetal growth restriction.
[So] Source:Am J Med Genet A;173(1):151-156, 2017 Jan.
[Is] ISSN:1552-4833
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An association between congenital malformations and fetal growth restriction (FGR) can be largely explained by a relationship with early embryonic hypocellularity. The malformations include the VACTERL association, which is exceptional as a Mendelian syndrome, but is commonly associated with monozygotic twinning, maternal diabetes, and some forms of aneuploidy, all characterized by a small embryo early in development. Parsimony suggests that these different links to VACTERL are related to the hypocellularity as a single common factor, rather than as an expression of three independent pathogenetic processes. A distinct non-genetic pathogenesis is further supported by increased frequencies in the same conditions of a single umbilical artery (SUA), which is also unusual in Mendelian disorders. SUA often involves the atrophy of one artery, which may be facilitated by altered hemodynamics in a smaller embryo, providing a direct link to hypocellularity. Hypocellularity may also explain a possible connection between VACTERL and certain mitochondrial disorders, where reduced energy might slow early cell division and growth, reducing the size of the embryo. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Anormalidades Múltiplas/diagnóstico
Anormalidades Múltiplas/genética
Retardo do Crescimento Fetal/diagnóstico
Retardo do Crescimento Fetal/genética
Estudos de Associação Genética
[Mh] Termos MeSH secundário: Aberrações Cromossômicas
Desenvolvimento Embrionário/genética
Feminino
Seres Humanos
Gravidez
Artéria Umbilical Única/diagnóstico
Artéria Umbilical Única/genética
Teratogênese/genética
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161008
[St] Status:MEDLINE
[do] DOI:10.1002/ajmg.a.37985


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[PMID]:27697599
[Au] Autor:Wertelecki W; Chambers CD; Yevtushok L; Zymak-Zakutnya N; Sosyniuk Z; Lapchenko S; Ievtushok B; Akhmedzhanova D; Komov O
[Ad] Endereço:Omni-Net for Children International Charitable Fund, Rivne, Ukraine; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA. Electronic address: genfir3@gmail.com.
[Ti] Título:Chornobyl 30 years later: Radiation, pregnancies, and developmental anomalies in Rivne, Ukraine.
[So] Source:Eur J Med Genet;60(1):2-11, 2017 Jan.
[Is] ISSN:1878-0849
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In the 30 years since the Chornobyl nuclear power plant disaster, there is evidence of persistent levels of incorporated ionizing radiation in adults, children and pregnant women in the surrounding area. Measured levels of Cesium-137 vary by region, and may be influenced by dietary and water sources as well as proximity to nuclear power plants. Since 2000, comprehensive, population-based birth defects monitoring has been performed in selected regions of Ukraine to evaluate trends and to generate hypotheses regarding potential causes of unexplained variations in defect rates. Significantly higher rates of microcephaly, neural tube defects, and microphthalmia have been identified in selected regions of Ukraine collectively known as Polissia compared to adjacent regions collectively termed non-Polissia, and these significantly higher rates were evident particularly in the years 2000-2009. The Polissia regions have also demonstrated higher mean whole body counts of Cesium-137 compared to values in individuals residing in other non-Polissia regions. The potential causal relationship between persistent ionizing radiation pollution and selected congenital anomaly rates supports the need for a more thorough, targeted investigation of the sources of persistent ionizing radiation and the biological plausibility of a potential teratogenic effect.
[Mh] Termos MeSH primário: Contaminação Radioativa do Ar/efeitos adversos
Radioisótopos de Césio/efeitos adversos
Acidente Nuclear de Chernobyl
Teratogênese/efeitos da radiação
[Mh] Termos MeSH secundário: Radioisótopos de Césio/isolamento & purificação
Feminino
Seres Humanos
Microcefalia/epidemiologia
Microcefalia/etiologia
Microcefalia/fisiopatologia
Microftalmia/epidemiologia
Microftalmia/etiologia
Microftalmia/fisiopatologia
Defeitos do Tubo Neural/epidemiologia
Defeitos do Tubo Neural/etiologia
Defeitos do Tubo Neural/fisiopatologia
Gravidez
Ucrânia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cesium Radioisotopes)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170210
[Lr] Data última revisão:
170210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161005
[St] Status:MEDLINE


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[PMID]:27671426
[Au] Autor:Melnik BC
[Ad] Endereço:Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, DE-49076 Osnabrück, Germany. Melnik@t-online.de.
[Ti] Título:Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity.
[So] Source:Acta Derm Venereol;97(2):173-181, 2017 Feb 08.
[Is] ISSN:1651-2057
[Cp] País de publicação:Sweden
[La] Idioma:eng
[Ab] Resumo:Isotretinoin (13-cis retinoic acid) is the most effective sebum-suppressive drug for the treatment of severe acne. Its effect depends on sebocyte apoptosis, which results from isotretinoin-induced expression of the apoptotic protein tumour necrosis factor-related apoptosis-inducing ligand, insulin-like growth factor-binding protein-3 and neutrophil gelatinase-associated lipocalin. This review proposes that the pharmacological mode of action of isotretinoin in the treatment of severe acne, acute promyelocytic leukaemia, and neuroblastoma results from apoptosis. Furthermore, apoptosis may be the underlying and unifying mechanism of the adverse effects of isotretinoin on neural crest cells (teratogenicity), hippocampal neurones (depression), epidermal keratinocytes and mucosa cells (mucocutaneous side-effects), hair follicle cells (telogen effluvium), intestinal epithelial cells (inflammatory bowel disease), skeletal muscle cells (myalgia and release of creatine kinase), and hepatocytes (release of transaminases and very low-density lipoproteins). Genetic variants of components of the apoptotic signalling cascade, such as RARA polymorphisms, might explain variations in the magnitude of isotretinoin-induced apoptotic signalling and apparently identify subgroups of patients who experience either stronger adverse effects with isotretinoin therapy or resistance to treatment.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Depressão/induzido quimicamente
Fármacos Dermatológicos/farmacologia
Isotretinoína/farmacologia
Teratogênese
[Mh] Termos MeSH secundário: Fármacos Dermatológicos/efeitos adversos
Hepatócitos/efeitos dos fármacos
Seres Humanos
Isotretinoína/efeitos adversos
Neoplasias/tratamento farmacológico
Glândulas Sebáceas/efeitos dos fármacos
Glândulas Sebáceas/patologia
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Dermatologic Agents); EH28UP18IF (Isotretinoin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170228
[Lr] Data última revisão:
170228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160928
[St] Status:MEDLINE
[do] DOI:10.2340/00015555-2535



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