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[PMID]:29216900
[Au] Autor:Ribas L; Vanezis K; Imués MA; Piferrer F
[Ad] Endereço:Institut de Ciències del Mar, Consejo Superior de Investigaciones Científicas (CSIC), Passeig Marítim, 37-45, 08003, Barcelona, Spain.
[Ti] Título:Treatment with a DNA methyltransferase inhibitor feminizes zebrafish and induces long-term expression changes in the gonads.
[So] Source:Epigenetics Chromatin;10(1):59, 2017 12 08.
[Is] ISSN:1756-8935
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The role of epigenetic modifications such as DNA methylation during vertebrate sexual development is far from being clear. Using the zebrafish model, we tested the effects of one of the most common DNA methyltransferase (dnmt) inhibitor, 5-aza-2'-deoxycytidine (5-aza-dC), which is approved for the treatment of acute myeloid leukaemia and is under active investigation for the treatment of solid tumours. Several dose-response experiments were carried out during two periods, including not only the very first days of development (0-6 days post-fertilization, dpf), as done in previous studies, but also, and as a novelty, the period of gonadal development (10-30 dpf). RESULTS: Early treatment with 5-aza-dC altered embryonic development, delayed hatching and increased teratology and mortality, as expected. The most striking result, however, was an increase in the number of females, suggesting that alterations induced by 5-aza-dC treatment can affect sexual development as well. Results were confirmed when treatment coincided with gonadal development. In addition, we also found that the adult gonadal transcriptome of 5-aza-dC-exposed females included significant changes in the expression of key reproduction-related genes (e.g. cyp11a1, esr2b and figla), and that several pro-female-related pathways such as the Fanconi anaemia or the Wnt signalling pathways were downregulated. Furthermore, an overall inhibition of genes implicated in epigenetic regulatory mechanisms (e.g. dnmt1, dicer, cbx4) was also observed. CONCLUSIONS: Taken together, our results indicate that treatment with a DNA methylation inhibitor can also alter the sexual development in zebrafish, with permanent alterations of the adult gonadal transcriptome, at least in females. Our results show the importance of DNA methylation for proper control of sexual development, open new avenues for the potential control of sex ratios in fish (aquaculture, population control) and call attention to possibly hidden long-term effects of dnmt therapy when used, for example, in the treatment of prepuberal children affected by some types of cancer.
[Mh] Termos MeSH primário: Metilases de Modificação do DNA/antagonistas & inibidores
Inibidores Enzimáticos/farmacologia
Feminização/induzido quimicamente
Ovário/efeitos dos fármacos
Peixe-Zebra/embriologia
[Mh] Termos MeSH secundário: Animais
Azacitidina/análogos & derivados
Azacitidina/farmacologia
Relação Dose-Resposta a Droga
Feminino
Masculino
Ovário/metabolismo
Razão de Masculinidade
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 776B62CQ27 (decitabine); EC 2.1.1.- (DNA Modification Methylases); M801H13NRU (Azacitidine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180310
[Lr] Data última revisão:
180310
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1186/s13072-017-0168-7


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[PMID]:28468220
[Au] Autor:Lam K; Ho T; Yao WC
[Ad] Endereço:*Department of Otolaryngology, Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, VA †Department of Otorhinolaryngology, Head and Neck Surgery, University of Texas McGovern Medical School, Houston, TX.
[Ti] Título:Sinocutaneous Fistula Formation After Forehead Recontouring Surgery for Transgender Patients.
[So] Source:J Craniofac Surg;28(3):e274-e277, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Forehead recontouring is a common part of facial feminization surgery. The procedure, which alters the shape and structure of the frontal bone, is regarded as safe and well tolerated by patients. The occurrence of delayed complications, however, is much less understood. The authors describe a patient involving the development of a sinocutaneous fistula as a delayed complication of forehead recontouring surgery. The clinical presentation and management of this patient are discussed. As facial feminization surgery expands as a cosmetic option for patients who desire more feminine facial features, practitioners should recognize the potential risk of sinonasal complications associated with forehead recontouring surgery.
[Mh] Termos MeSH primário: Fístula Cutânea/etiologia
Feminização
Testa/cirurgia
Doenças dos Seios Paranasais/etiologia
Complicações Pós-Operatórias
Ritidoplastia/efeitos adversos
Pessoas Transgênero
[Mh] Termos MeSH secundário: Idoso
Fístula Cutânea/diagnóstico
Endoscopia
Feminino
Fístula/diagnóstico
Fístula/etiologia
Seio Frontal
Seres Humanos
Masculino
Doenças dos Seios Paranasais/diagnóstico
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003524


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[PMID]:28911174
[Au] Autor:Hirst CE; Major AT; Ayers KL; Brown RJ; Mariette M; Sackton TB; Smith CA
[Ad] Endereço:Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
[Ti] Título:Sex Reversal and Comparative Data Undermine the W Chromosome and Support Z-linked DMRT1 as the Regulator of Gonadal Sex Differentiation in Birds.
[So] Source:Endocrinology;158(9):2970-2987, 2017 Sep 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The exact genetic mechanism regulating avian gonadal sex differentiation has not been completely resolved. The most likely scenario involves a dosage mechanism, whereby the Z-linked DMRT1 gene triggers testis development. However, the possibility still exists that the female-specific W chromosome may harbor an ovarian determining factor. In this study, we provide evidence that the universal gene regulating gonadal sex differentiation in birds is Z-linked DMRT1 and not a W-linked (ovarian) factor. Three candidate W-linked ovarian determinants are HINTW, female-expressed transcript 1 (FET1), and female-associated factor (FAF). To test the association of these genes with ovarian differentiation in the chicken, we examined their expression following experimentally induced female-to-male sex reversal using the aromatase inhibitor fadrozole (FAD). Administration of FAD on day 3 of embryogenesis induced a significant loss of aromatase enzyme activity in female gonads and masculinization. However, expression levels of HINTW, FAF, and FET1 were unaltered after experimental masculinization. Furthermore, comparative analysis showed that FAF and FET1 expression could not be detected in zebra finch gonads. Additionally, an antibody raised against the predicted HINTW protein failed to detect it endogenously. These data do not support a universal role for these genes or for the W sex chromosome in ovarian development in birds. We found that DMRT1 (but not the recently identified Z-linked HEMGN gene) is male upregulated in embryonic zebra finch and emu gonads, as in the chicken. As chicken, zebra finch, and emu exemplify the major evolutionary clades of birds, we propose that Z-linked DMRT1, and not the W sex chromosome, regulates gonadal sex differentiation in birds.
[Mh] Termos MeSH primário: Aves
Cromossomos Sexuais/genética
Processos de Determinação Sexual/genética
Diferenciação Sexual/genética
Fatores de Transcrição/fisiologia
[Mh] Termos MeSH secundário: Animais
Aves/embriologia
Aves/genética
Embrião de Galinha
Galinhas
Desenvolvimento Embrionário
Feminino
Feminização/embriologia
Feminização/genética
Tentilhões/embriologia
Tentilhões/genética
Regulação da Expressão Gênica no Desenvolvimento
Gônadas
Masculino
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DMRT1 protein); 0 (Transcription Factors)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00316


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[PMID]:28350188
[Au] Autor:Plemons E
[Ad] Endereço:a School of Anthropology, University of Arizona , Tucson , Arizona , USA.
[Ti] Título:Formations of Femininity: Science and Aesthetics in Facial Feminization Surgery.
[So] Source:Med Anthropol;36(7):629-641, 2017 Oct.
[Is] ISSN:1545-5882
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Facial feminization surgery (FFS) is a set of bone and soft tissue reconstructive surgical procedures intended to feminize the faces of trans- women in order to make their identities as women recognizable to others. In this article, I explore how the identification of facial femininity was negotiated in two FFS surgeons' practices. One committed to the metrics of normal skeletal form and the other to aspirational aesthetics of individual optimization; I argue that surgeons' competing clinical approaches illustrate a constitutive tension in the proliferating therapeutic logics of trans- medicine. The growing popularity of surgical practices like FFS demonstrates a shift in American trans- therapeutics away from a singular focus on the genitalia as the location of bodily sex and toward understandings of sex as a product of social recognition.
[Mh] Termos MeSH primário: Face/cirurgia
Feminização/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/métodos
Transexualismo/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Antropologia Médica
Estética
Feminino
Seres Humanos
Masculino
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170329
[St] Status:MEDLINE
[do] DOI:10.1080/01459740.2017.1298593


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[PMID]:28064479
[Au] Autor:White JW; Cole BJ; Cherr GN; Connon RE; Brander SM
[Ad] Endereço:Department of Biology and Marine Biology, University of North Carolina Wilmington , Wilmington, North Carolina 28403 United States.
[Ti] Título:Scaling Up Endocrine Disruption Effects from Individuals to Populations: Outcomes Depend on How Many Males a Population Needs.
[So] Source:Environ Sci Technol;51(3):1802-1810, 2017 Feb 07.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Assessing how endocrine disrupting compounds (EDCs) affect population dynamics requires tracking males and females (and sex-reversed individuals) separately. A key component in any sex-specific model is the "mating function" (the relationship between sex ratio and reproductive success) but this relationship is not known for any fish species. Using a model, we found that EDC effects on fish populations strongly depend upon the shape of the mating function. Additionally, masculinization is generally more detrimental to populations than feminization. We then quantified the mating function for the inland silverside (Menidia beryllina), and used those results and the model to assess the status of wild silverside populations. Contrary to the expectation that a few males can spawn with many females, silversides exhibited a nearly linear mating function. This implies that small changes in the sex ratio will reduce reproductive success. Four out of five wild silverside populations exhibited sex ratios far from 50:50 and thus are predicted to be experiencing population declines. Our results suggest that managers should place more emphasis on mitigating masculinizing rather than feminizing EDC effects. However, for species with a nearly linear mating function, such as Menidia, feminization and masculinization are equally detrimental.
[Mh] Termos MeSH primário: Disruptores Endócrinos/toxicidade
Peixes
Dinâmica Populacional
[Mh] Termos MeSH secundário: Animais
Feminização
Seres Humanos
Masculino
Reprodução/efeitos dos fármacos
Smegmamorpha
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Endocrine Disruptors)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE
[do] DOI:10.1021/acs.est.6b05276


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Simón, Daniel
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[PMID]:27978554
[Au] Autor:Bellinga RJ; Capitán L; Simon D; Tenório T
[Ad] Endereço:FACIALTEAM Surgical Group, Marbella High Care International Hospital, Marbella, Málaga, Spain.
[Ti] Título:Technical and Clinical Considerations for Facial Feminization Surgery With Rhinoplasty and Related Procedures.
[So] Source:JAMA Facial Plast Surg;19(3):175-181, 2017 May 01.
[Is] ISSN:2168-6092
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Together with the forehead reconstruction, feminization of the nose is one of the most common procedures in facial feminization surgery. Rhinoplasty surgical techniques, which provide correct support and stability in the midterm to long term, are essential for obtaining a predictable result. Objective: To report on the technical and clinical considerations of rhinoplasty and related procedures to feminize the nose, harmonize the nose in relation to the other modified structures (mainly the forehead and maxillomandibular complex), and achieve an aesthetic result beyond gender differences. Design, Setting, and Participants: Case series study of feminization rhinoplasties, in combination with lip-lift techniques, forehead reconstruction, and other procedures, were performed at a private practice between January 11, 2010, and May 29, 2015, in 200 consecutive male-to-female transgender patients. The mean (SD) medical follow-up for patients was 32 (18.84) months (range, 12-77 months). Frontonasal angles were objectively measured. Postoperative and long-term patient satisfaction were assessed. Main Outcomes and Measures: Clinical analysis and evaluation using the 5-point Nose Feminization Scale, with 1 indicating very masculine or nose is worse and 5 indicating very feminine or exceptional result. Results: In these 200 patients, the mean (SD) age was 40.2 (12.2) years (range, 18-70 years). The mean (SE) frontonasal angle changed from 133.64° (0.63°) to 149.08° (0.57°) (difference in means, -15.44; 95% CI, -17.12 to -13.76; P < .001). Most patients considered their nose to appear more feminine after the surgery, and the degree of satisfaction after the rhinoplasty was 4 (much better) of 5 points on the Nose Feminization Scale. During the evaluation of feminization rhinoplasties, special attention was given to how the nose relates to other features essential to the identification of facial gender: the forehead and maxillomandibular complex. Emphasis was placed on the midterm to long-term stability of the results by reinforcing the internal structure. Conclusions and Relevance: In this case series of feminization rhinoplasties in combination with lip-lift techniques and forehead reconstruction, frontonasal angles were changed, and patient satisfaction with outcomes was high. The main goal of rhinoplasty in facial feminization surgery is to obtain feminine nasal features and the harmonization of the nose with the rest of the face. Lip-lifts and frontonasal recontouring can complement rhinoplasties associated with facial feminization surgery. Level of Evidence: 4.
[Mh] Termos MeSH primário: Feminização
Testa/cirurgia
Lábio/cirurgia
Rinoplastia/métodos
Pessoas Transgênero
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Estética
Seres Humanos
Masculino
Meia-Idade
Satisfação do Paciente
Procedimentos Cirúrgicos Reconstrutivos/métodos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE
[do] DOI:10.1001/jamafacial.2016.1572


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[PMID]:27942897
[Au] Autor:Casado JC; Rodríguez-Parra MJ; Adrián JA
[Ad] Endereço:ENT-Quirón Hospital Service, Marbella, Málaga, Spain.
[Ti] Título:Voice feminization in male-to-female transgendered clients after Wendler's glottoplasty with vs. without voice therapy support.
[So] Source:Eur Arch Otorhinolaryngol;274(4):2049-2058, 2017 Apr.
[Is] ISSN:1434-4726
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to evaluate the medium-term results of Wendler's glottoplasty surgery (WG) and the effects of post-operative voice therapy in a group of male-to-female transsexuals. This is a retrospective study of 18 transsexuals who voluntarily underwent WG between 2010 and 2014 at a single hospital. Ten of the subjects underwent an additional voice therapy training. The group was assessed pre- vs. post-treatments with a limited battery of measures consisting of fundamental frequency (Fo), maximum phonation time, the TSEQ transgender self-assessment questionnaire, and perceptual assessment of the voice (Visual Analog Scale and a simplified version of the classical Hirano-GRBAS scale) by inter-rater agreement. The surgical procedure consisted of a de-epithelialization of the anterior third of both vocal folds; this area was sutured, and the surface of both vocal folds was vaporized with a laser diode. The results showed a significant increase in vocal tone and feminization of voice in all participants, including a significant increase in Fo 12 months after treatment. Significant improvements were also shown in other evaluated measures, such as self-reported satisfaction and the degree of feminization of the voice. However, no improvements in maximum phonation time were observed. The use of voice therapy appears decisive for optimal improvement of this class of patients. WG applied appropriately by well-trained hands is thus a very effective and less traumatic procedure than other techniques that aim for an acceptable feminization of the voice in MtoF transgendered clients.
[Mh] Termos MeSH primário: Feminização/fisiopatologia
Acústica da Fala
Pessoas Transgênero/psicologia
Prega Vocal
Qualidade da Voz/fisiologia
Treinamento da Voz
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Terapia a Laser/métodos
Masculino
Meia-Idade
Estudos Retrospectivos
Autoavaliação
Espanha
Inquéritos e Questionários
Resultado do Tratamento
Prega Vocal/fisiopatologia
Prega Vocal/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE
[do] DOI:10.1007/s00405-016-4420-8


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[PMID]:27328327
[Au] Autor:Kim HT
[Ad] Endereço:Yeson Voice Center, Institute of Performing Art Medicine, Seoul, South Korea.
[Ti] Título:A New Conceptual Approach for Voice Feminization: 12 Years of Experience.
[So] Source:Laryngoscope;127(5):1102-1108, 2017 May.
[Is] ISSN:1531-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES/HYPOTHESIS: Voice feminization has been developed with various surgical techniques to increase voice pitch. The purpose of this study was to evaluate 12 years of experience using a new endoscopical surgical technique, vocal fold shortening and retrodisplacement of the anterior commissure (VFSRAC) and retraining the voice pattern performed in female patients with androphonia or male-to-female transsexuals. STUDY DESIGN: Retrospective study. METHODS: A retrospective study was performed on 362 patients who underwent VFSRAC (34 with androphonia, eight with androgenital syndrome, four with aplastic anemia treated with androgens, three with pseudohermaphroditism, and 313 male-to-female [MTF] transsexuals) and phonatory pattern rehabilitation between 2003 and 2014. Subjective and perceptual assessments, aerodynamic and acoustic assessments, and a videostroboscopic assessment were evaluated pre- and postoperatively in the female androphonia group and the MTF transsexual group. RESULTS: Mean preoperative fundamental frequency (F ) was 144.1 Hz, and mean postoperative F was 207.4 Hz, 6 months postoperatively. The mean increase of F in the female androphonia group was 53.0 Hz but was 73.6 Hz in the MTF transsexual group after the postoperative phonatory pattern retraining program. Voice femininity increased on the postoperative subjective assessment. Acoustic and aerodynamic assessments were within the normal range. Regularity of the vocal fold mucosal wave were maintained in the normal range. These findings suggest that patients could achieve a natural phonation pattern after surgery. CONCLUSIONS: Our new approach for voice feminization, VFSRAC, and retraining of the phonatory pattern was effective for patients who wanted a natural feminine voice. LEVEL OF EVIDENCE: 4 Laryngoscope, 127:1102-1108, 2017.
[Mh] Termos MeSH primário: Feminização
Laringoscopia/métodos
Pessoas Transgênero
Prega Vocal/cirurgia
Qualidade da Voz
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Estroboscopia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160622
[St] Status:MEDLINE
[do] DOI:10.1002/lary.26127


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[PMID]:26809497
[Au] Autor:Stout MB; Steyn FJ; Jurczak MJ; Camporez JG; Zhu Y; Hawse JR; Jurk D; Palmer AK; Xu M; Pirtskhalava T; Evans GL; de Souza Santos R; Frank AP; White TA; Monroe DG; Singh RJ; Casaclang-Verzosa G; Miller JD; Clegg DJ; LeBrasseur NK; von Zglinicki T; Shulman GI; Tchkonia T; Kirkland JL
[Ad] Endereço:Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.
[Ti] Título:17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization.
[So] Source:J Gerontol A Biol Sci Med Sci;72(1):3-15, 2017 Jan.
[Is] ISSN:1758-535X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Aging is associated with visceral adiposity, metabolic disorders, and chronic low-grade inflammation. 17α-estradiol (17α-E2), a naturally occurring enantiomer of 17ß-estradiol (17ß-E2), extends life span in male mice through unresolved mechanisms. We tested whether 17α-E2 could alleviate age-related metabolic dysfunction and inflammation. 17α-E2 reduced body mass, visceral adiposity, and ectopic lipid deposition without decreasing lean mass. These declines were associated with reductions in energy intake due to the activation of hypothalamic anorexigenic pathways and direct effects of 17α-E2 on nutrient-sensing pathways in visceral adipose tissue. 17α-E2 did not alter energy expenditure or excretion. Fasting glucose, insulin, and glycosylated hemoglobin were also reduced by 17α-E2, and hyperinsulinemic-euglycemic clamps revealed improvements in peripheral glucose disposal and hepatic glucose production. Inflammatory mediators in visceral adipose tissue and the circulation were reduced by 17α-E2. 17α-E2 increased AMPKα and reduced mTOR complex 1 activity in visceral adipose tissue but not in liver or quadriceps muscle, which is in contrast to the generalized systemic effects of caloric restriction. These beneficial phenotypic changes occurred in the absence of feminization or cardiac dysfunction, two commonly observed deleterious effects of exogenous estrogen administration. Thus, 17α-E2 holds potential as a novel therapeutic for alleviating age-related metabolic dysfunction through tissue-specific effects.
[Mh] Termos MeSH primário: Adiposidade/efeitos dos fármacos
Envelhecimento/fisiologia
Estradiol/farmacologia
Estrogênios/farmacologia
Metabolismo dos Lipídeos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Índice de Massa Corporal
Feminização
Gordura Intra-Abdominal/efeitos dos fármacos
Masculino
Camundongos
Camundongos Endogâmicos C57BL
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estrogens); 4TI98Z838E (Estradiol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160127
[St] Status:MEDLINE


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[PMID]:27853073
[Au] Autor:Hatano M; Takenaka Y; Inoue I; Homma K; Hasegawa T; Sasano H; Awata T; Katayama S
[Ad] Endereço:Department of Endocrinology and Diabetes, Saitama Medical University, Japan.
[Ti] Título:Feminizing Adrenocortical Carcinoma with Distinct Histopathological Findings.
[So] Source:Intern Med;55(22):3301-3307, 2016.
[Is] ISSN:1349-7235
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological diagnosis was adrenocortical carcinoma. The results of immunostaining indicated a virilizing tumor. Aromatase activity was identified on RT-PCR. As disorganized steroidogenesis is pathologically present in adrenocortical carcinoma, this diagnosis should be made with caution.
[Mh] Termos MeSH primário: Neoplasias do Córtex Suprarrenal/complicações
Carcinoma Adrenocortical/complicações
Feminização/etiologia
[Mh] Termos MeSH secundário: Neoplasias do Córtex Suprarrenal/diagnóstico
Neoplasias do Córtex Suprarrenal/cirurgia
Adrenalectomia
Carcinoma Adrenocortical/diagnóstico
Carcinoma Adrenocortical/cirurgia
Sulfato de Desidroepiandrosterona/sangue
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Cintilografia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
57B09Q7FJR (Dehydroepiandrosterone Sulfate)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161118
[St] Status:MEDLINE



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