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Pesquisa : C23.888.571.800 [Categoria DeCS]
Referências encontradas : 194 [refinar]
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[PMID]:26802378
[Au] Autor:Chen W; Chao JG; Wang JK; Chen XW; Tan C
[Ad] Endereço:National Key Laboratory of Human Factors Engineering and the State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
[Ti] Título:Subjective Vertical Conflict Theory and Space Motion Sickness.
[So] Source:Aerosp Med Hum Perform;87(2):128-36, 2016 Feb.
[Is] ISSN:2375-6314
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Space motion sickness (SMS) remains a troublesome problem during spaceflight. The subjective vertical (SV) conflict theory postulates that all motion sickness provoking situations are characterized by a condition in which the SV sensed from gravity and visual and idiotropic cues differs from the expected vertical. This theory has been successfully used to predict motion sickness in different vehicles on Earth. METHOD: We have summarized the most outstanding and recent studies on the illusions and characteristics associated with spatial disorientation and SMS during weightlessness, such as cognitive map and mental rotation, the visual reorientation and inversion illusions, and orientation preferences between visual scenes and the internal z-axis of the body. RESULTS: The relationships between the SV and the incidence of and susceptibility to SMS as well as spatial disorientation were addressed. CONCLUSION: A consistent framework was presented to understand and explain SMS characteristics in more detail on the basis of the SV conflict theory, which is expected to be more advantageous in SMS prediction, prevention, and training.
[Mh] Termos MeSH primário: Medicina Aeroespacial
Sensação Gravitacional/fisiologia
Transtornos das Sensações/fisiopatologia
Enjoo devido ao Movimento em Voo Espacial/fisiopatologia
Percepção Espacial/fisiologia
[Mh] Termos MeSH secundário: Movimentos da Cabeça/fisiologia
Seres Humanos
Transtornos das Sensações/epidemiologia
Enjoo devido ao Movimento em Voo Espacial/epidemiologia
Percepção Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1603
[Cu] Atualização por classe:160124
[Lr] Data última revisão:
160124
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:160124
[St] Status:MEDLINE
[do] DOI:10.3357/AMHP.4327.2016


  2 / 194 MEDLINE  
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[PMID]:26624575
[Au] Autor:Van Ombergen A; Lawson BD; Wuyts FL
[Ad] Endereço:a Antwerp University Research Centre for Equilibrium and Aerospace (AUREA), University of Antwerp Groenenborgerlaan , Antwerp , 171, 2020 , Belgium and.
[Ti] Título:Motion sickness and sopite syndrome associated with parabolic flights: a case report.
[So] Source:Int J Audiol;55(3):189-94, 2016.
[Is] ISSN:1708-8186
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The purpose of this paper was to provide an extensive description of a case of sopite syndrome, a manifestation of motion sickness scarcely described in the literature. DESIGN: The following questionnaires were used to assess sopite syndrome symptoms pre, during and post parabolic flight; Misery Scale rate, Positive and Negative Affect Scale, the Motion Sickness Assessment Questionnaire and the Epworth Sleepiness Scale. STUDY SAMPLE: Case report of a 35-year old female compared to a control group (n = 26). RESULTS: We describe of sopite syndrome during parabolic flight. The subject reported drowsiness and she noted mood changes such as irritation and annoyance. Furthermore, she was not able to perform her assigned task. Her symptoms escalated into extreme fatigue and the inability to stay awake. Nauseogenic symptoms improved, but soporific symptoms persisted for several hours after the motion stimulus (i.e. parabolic flight). CONCLUSIONS: This case points towards the need for controlled studies to assess the prevalence of this syndrome among the general population and select groups. Future research should focus on developing tests for personnel screening and explore treatment options.
[Mh] Termos MeSH primário: Enjoo devido ao Movimento em Voo Espacial
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151202
[St] Status:MEDLINE
[do] DOI:10.3109/14992027.2015.1111526


  3 / 194 MEDLINE  
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[PMID]:26630192
[Au] Autor:Kozlovskaya IB; Yarmanova EN; Yegorov AD; Stepantsov VI; Fomina EV; Tomilovaskaya ES
[Ad] Endereço:Institute for Biomedical Problems, Moscow, Russia.
[Ti] Título:Russian Countermeasure Systems for Adverse Effects of Microgravity on Long-Duration ISS Flights.
[So] Source:Aerosp Med Hum Perform;86(12 Suppl):A24-31, 2015 Dec.
[Is] ISSN:2375-6314
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The system of countermeasures for the adverse effects of microgravity developed in the USSR supported the successful implementation of long-duration spaceflight (LDS) programs on the Salyut and Mir orbital stations and was subsequently adapted for flights on the International Space Station (ISS). From 2000 through 2010, crews completed 26 ISS flight increments ranging in duration from 140 to 216 d, with the participation of 27 Russian cosmonauts. These flights have made it possible to more precisely determine a crew-member's level of conditioning, better assess the advantages and disadvantages of training processes, and determine prospects for future developments.
[Mh] Termos MeSH primário: Exercício
Voo Espacial
Contramedidas de Ausência de Peso
Ausência de Peso
[Mh] Termos MeSH secundário: Astronautas
Seres Humanos
Atrofia Muscular
Federação Russa
Enjoo devido ao Movimento em Voo Espacial
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1604
[Cu] Atualização por classe:151203
[Lr] Data última revisão:
151203
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:151203
[St] Status:MEDLINE
[do] DOI:10.3357/AMHP.EC04.2015


  4 / 194 MEDLINE  
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[PMID]:26608378
[Au] Autor:Barchukov VV; Zhavbert ES; Dugina YL; Epstein OI
[Ad] Endereço:Materia Medica Holding, Moscow, Russia.
[Ti] Título:The Use of Release-Active Antibody-Based Preparations for Vertigo Prevention in Adults.
[So] Source:Bull Exp Biol Med;160(1):61-3, 2015 Nov.
[Is] ISSN:1573-8221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The effectiveness of antibody-based release-active preparations Impaza (antibodies to eNOS), Tenoten (antibodies to brain-specific protein S-100), Dietressa (antibodies to type 1 cannabinoid receptor), Brizantin (combined preparation, antibodies to brain-specific protein S-100 and type 1 cannabinoid receptor), and Divaza (combined preparation, antibodies to brain-specific protein S-100 and eNOS) in the prevention of vertigo was studied on the model of intermittent accumulation of Coriolis accelerations (ICCA). Modification of activity of vestibular receptors and signal systems by release-active preparations contributed to an increase in ICCA tolerance time. Combined preparation Impaza possessed the most significant antinaupathic properties. Brizantin was less potent in this respect.
[Mh] Termos MeSH primário: Anticorpos/uso terapêutico
Enjoo devido ao Movimento em Voo Espacial/prevenção & controle
[Mh] Termos MeSH secundário: Aceleração/efeitos adversos
Adolescente
Adulto
Força Coriolis
Método Duplo-Cego
Combinação de Medicamentos
Feminino
Seres Humanos
Masculino
Meia-Idade
Náusea/etiologia
Náusea/fisiopatologia
Náusea/prevenção & controle
Óxido Nítrico Sintase Tipo III/imunologia
Disautonomias Primárias/etiologia
Disautonomias Primárias/fisiopatologia
Disautonomias Primárias/prevenção & controle
Receptor CB1 de Canabinoide/imunologia
Proteínas S100/imunologia
Índice de Gravidade de Doença
Enjoo devido ao Movimento em Voo Espacial/etiologia
Enjoo devido ao Movimento em Voo Espacial/fisiopatologia
Vestíbulo do Labirinto/efeitos dos fármacos
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antibodies); 0 (Brizantin); 0 (CNR1 protein, human); 0 (Dietressa); 0 (Drug Combinations); 0 (IMPAZA); 0 (Receptor, Cannabinoid, CB1); 0 (S100 Proteins); 0 (divaza); 0 (tenoten); EC 1.14.13.39 (NOS3 protein, human); EC 1.14.13.39 (Nitric Oxide Synthase Type III)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151207
[Lr] Data última revisão:
151207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151127
[St] Status:MEDLINE
[do] DOI:10.1007/s10517-015-3098-z


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[PMID]:26055239
[Au] Autor:Prakash M; Fried R; Götze O; May F; Frings-Meuthen P; Mulder E; Valentini J; Fox M; Fried M; Schwizer W; Misselwitz B
[Ad] Endereço:Division of Gastroenterology and Hepatology, University Hospital Zurich and Zurich University, Rämistr. 100, 8091, Zurich, Switzerland.
[Ti] Título:Microgravity Simulated by the 6° Head-Down Tilt Bed Rest Test Increases Intestinal Motility but Fails to Induce Gastrointestinal Symptoms of Space Motion Sickness.
[So] Source:Dig Dis Sci;60(10):3053-61, 2015 Oct.
[Is] ISSN:1573-2568
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Space motion sickness (SMS) is the most relevant medical problem during the first days in microgravity. Studies addressing pathophysiology in space face severe technical challenges and microgravity is frequently simulated using the 6° head-down tilt bed rest test (HDT). AIM: We were aiming to test whether SMS could be simulated by HDT, identify related changes in gastrointestinal physiology and test for beneficial effects of exercise interventions. METHODS: HDT was performed in ten healthy individuals. Each individual was tested in three study campaigns varying by a 30-min daily exercise intervention of either standing, an upright exercise regimen, or no intervention. Gastrointestinal symptoms, stool characteristics, gastric emptying time, and small intestinal transit were assessed using standardized questionnaires, (13)C octanoate breath test, and H2 lactulose breath test, respectively, before and at day 2 and 5 of HDT. RESULTS: Individuals described no or minimal gastrointestinal symptoms during HDT. Gastric emptying remained unchanged relative to baseline data collection (BDC). At day 2 of HDT the H2 peak of the lactulose test appeared earlier (mean ± standard error for BDC-1, HDT2, HDT5: 198 ± 7, 139 ± 18, 183 ± 10 min; p: 0.040), indicating accelerated small intestinal transit. Furthermore, during HDT, stool was softer and stool mass increased (BDC: 47 ± 6, HDT: 91 ± 12, recovery: 53 ± 8 g/day; p: 0.014), indicating accelerated colonic transit. Exercise interventions had no effect. CONCLUSION: HDT did not induce symptoms of SMS. During HDT, gastric emptying remained unchanged, but small and large intestinal transit was accelerated.
[Mh] Termos MeSH primário: Esvaziamento Gástrico/fisiologia
Trânsito Gastrointestinal/fisiologia
Decúbito Inclinado com Rebaixamento da Cabeça
Enjoo devido ao Movimento em Voo Espacial/fisiopatologia
Simulação de Ausência de Peso/métodos
[Mh] Termos MeSH secundário: Adulto
Repouso em Cama
Estudos Cross-Over
Feminino
Voluntários Saudáveis
Seres Humanos
Masculino
Meia-Idade
Postura
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1512
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:150610
[St] Status:MEDLINE
[do] DOI:10.1007/s10620-015-3738-1


  6 / 194 MEDLINE  
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[PMID]:25730653
[Au] Autor:Clément G; Bareille MP; Goel R; Linnarsson D; Mulder E; Paloski WH; Rittweger J; Wuyts FL; Zange J
[Ad] Endereço:International Space University, Strasbourg, France.
[Ti] Título:Effects of five days of bed rest with intermittent centrifugation on neurovestibular function.
[So] Source:J Musculoskelet Neuronal Interact;15(1):60-8, 2015 Mar.
[Is] ISSN:1108-7161
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: We tested whether intermittent short-radius centrifugation was effective for mitigating alteration in balance and gait following bed rest. METHODS: Ten male subjects were exposed to 5 days of 6° head-down tilt bed rest with: (a) no countermeasure; (b) daily 1-g centrifugation for a continuous 30-min period; and (c) daily 1-g centrifugation for six periods of 5 min. During and after the bed rest, subjects were asked to scale the severity of neurovestibular symptoms that followed centrifugation or 80° head-up tilt. Following the bed rest, equilibrium scores were derived from anterior-posterior sway while standing on a foam pad with the eyes open or closed while making pitch head movements, and gait was evaluated by grading subjects' performance during various locomotion tasks. RESULTS: At the beginning of bed rest, one single 30-min period of centrifugation induced more severe neurovestibular symptoms than six periods of 5-min centrifugation. After bed rest, although equilibrium scores and gait performance were not significantly altered, subjects felt less neurovestibular dysfunction with orthostatic stress when centrifugation was used. CONCLUSION: Centrifugation was effective at reducing the severity of neurovestibular symptoms after bed rest, but this decrease was not different between one or multiple daily sessions.
[Mh] Termos MeSH primário: Centrifugação
Gravidade Alterada
Enjoo devido ao Movimento em Voo Espacial/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Repouso em Cama
Decúbito Inclinado com Rebaixamento da Cabeça
Seres Humanos
Masculino
Testes de Função Vestibular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1511
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150303
[St] Status:MEDLINE


  7 / 194 MEDLINE  
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[PMID]:25647233
[Au] Autor:Chen W; Chao JG; Chen XW; Wang JK; Tan C
[Ad] Endereço:National Key Laboratory of Human Factors Engineering, China Astronaut Research and Training Center, Beijing 10094, China.
[Ti] Título:Quantitative orientation preference and susceptibility to space motion sickness simulated in a virtual reality environment.
[So] Source:Brain Res Bull;113:17-26, 2015 Apr.
[Is] ISSN:1873-2747
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Orientation preference should appear when variable weightings of spatial orientation cues are used between individuals. It is possible that astronauts' orientation preferences could be a potential predictor for susceptibility to space motion sickness (SMS). The present study was conducted to confirm this relationship on Earth by quantifying orientation preferences and simulating SMS in a virtual reality environment. Two tests were carried out. The first was to quantitatively determine one's orientation preference. Thirty-two participants' vision and body cue preferences were determined by measuring perceptual up (PU) orientations. The ratio of vision and body vector (ROVB) was used as the indicator of one's orientation preference. The second test was to visually induce motion sickness symptoms that represent similar sensory conflicts as SMS using a virtual reality environment. Relationships between ROVB values and motion sickness scores were analyzed, which revealed cubic functions by using optimal fits. According to ROVB level, participants were divided into three groups - body group, vision group, and confusion group - and the factor of gender was further considered as a covariate in the analysis. Consistent differences in motion sickness scores were observed between the three groups. Thus, orientation preference had a significant relationship with susceptibility to simulated SMS symptoms. This knowledge could assist with astronaut selection and might be a useful countermeasure when developing new preflight trainings.
[Mh] Termos MeSH primário: Orientação/fisiologia
Enjoo devido ao Movimento em Voo Espacial/etiologia
[Mh] Termos MeSH secundário: Adulto
Simulação por Computador
Suscetibilidade a Doenças
Feminino
Seres Humanos
Masculino
Valor Preditivo dos Testes
Voo Espacial
Enjoo devido ao Movimento em Voo Espacial/prevenção & controle
Navegação Espacial/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150403
[Lr] Data última revisão:
150403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150204
[St] Status:MEDLINE


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[PMID]:24919385
[Au] Autor:Weerts AP; Vanspauwen R; Fransen E; Jorens PG; Van de Heyning PH; Wuyts FL
[Ti] Título:Space motion sickness countermeasures: a pharmacological double-blind, placebo-controlled study.
[So] Source:Aviat Space Environ Med;85(6):638-44, 2014 Jun.
[Is] ISSN:0095-6562
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Space motion sickness (SMS), caused by a canal-otolith conflict, is currently treated with intramuscular promethazine. However, the drug has an inconsistent efficacy against SMS. We hypothesize that pharmacological depression of the semicircular canals (SCC) might relieve SMS. The aim of the present study was to identify the effects of meclizine (25 mg), dimenhydrinate (40 mg) combined with cinnarizine (25 mg), and promethazine (25 mg) combined with d-amphetamine (10 mg) on the SCCs and the otoliths. METHODS: This double-blind, placebo-controlled study was performed on 20 healthy men. Function of the SCC was evaluated by means of an electronystagmography, whereas utricular function was assessed by a unilateral centrifugation test. A cervical vestibular evoked myogenic potentials test evaluated saccular function. RESULTS: Meclizine (0.54 +/- 0.05 vs. 0.38 +/- 0.06) and dimenhydrinate with cinnarizine (0.54 +/- 0.05 vs. 0.45 +/- 0.05) decreased the vestibulo-ocular reflex gain. Promethazine with d-amphetamine decreased the latency of the saccadic eye response (right eye: 185 +/- 3.8 ms vs. 165 +/- 4.5 ms; left eye: 181 +/- 4.9 ms vs. 165 +/- 4.8 ms) and also increased the phase of ocular counterrolling measured during unilateral centrifugation (0.32 +/- 0.35 degrees vs. 1.5 +/- 0.45 degrees). DISCUSSION: It is hypothesized that meclizine and dimenhydrinate with cinnarizine affect the medial vestibular nucleus. Promethazine is a vestibular suppressor, but study results show that d-amphetamine counterbalances this depression and abolishes the effect of fatigue on the saccadic reaction time The hypothesis that a SCC-suppression alleviates SMS should be further evaluated.
[Mh] Termos MeSH primário: Antieméticos/uso terapêutico
Antagonistas dos Receptores Histamínicos H1/uso terapêutico
Enjoo devido ao Movimento em Voo Espacial/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Método Duplo-Cego
Voluntários Saudáveis
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiemetics); 0 (Histamine H1 Antagonists)
[Em] Mês de entrada:1407
[Cu] Atualização por classe:140612
[Lr] Data última revisão:
140612
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:140613
[St] Status:MEDLINE


  9 / 194 MEDLINE  
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[PMID]:23855067
[Au] Autor:Thornton WE; Bonato F
[Ad] Endereço:Montclair Stat University, Montclair, NJ, USA. jwthornt@msn.com
[Ti] Título:Space motion sickness and motion sickness: symptoms and etiology.
[So] Source:Aviat Space Environ Med;84(7):716-21, 2013 Jul.
[Is] ISSN:0095-6562
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The adverse symptoms of space motion sickness (SMS) have remained problematic since the beginning of manned spaceflight. Despite over 50 yr of research SMS remains a problem that affects about half of all space travelers during the first 24-72 h of a spaceflight. SMS has been treated as another form of motion sickness (MS) despite distinct differences in symptomology. In this review SMS and MS differences are examined and documented based on available data. Vestibular biomechanics that occur during weightlessness coupled with theoretical assertions regarding human evolution have led us to propose a two-component model of SMS. The first component involves conflicting sensory signals inherent to the otolith organs that occur during weightlessness. The second component is a bimodal conflict between the otoliths and semicircular canals that can occur during normal head movements in weightlessness. Both components may inadvertently, and mistakenly, signal that a vestibular malfunction has occurred, hence initiating a protective mechanism that may produce symptoms that discourage activity.
[Mh] Termos MeSH primário: Enjoo devido ao Movimento em Voo Espacial/fisiopatologia
Doenças Vestibulares/fisiopatologia
[Mh] Termos MeSH secundário: Seres Humanos
Enjoo devido ao Movimento/etiologia
Enjoo devido ao Movimento/fisiopatologia
Enjoo devido ao Movimento em Voo Espacial/etiologia
Doenças Vestibulares/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1308
[Cu] Atualização por classe:130716
[Lr] Data última revisão:
130716
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:130717
[St] Status:MEDLINE


  10 / 194 MEDLINE  
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[PMID]:23713225
[Au] Autor:Dalitsch WW
[Ti] Título:This month in Aerospace Medicine history.
[So] Source:Aviat Space Environ Med;84(5):544, 2013 May.
[Is] ISSN:0095-6562
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Medicina Aeroespacial/história
[Mh] Termos MeSH secundário: Acidentes Aeronáuticos
Bebidas Alcoólicas
Depressores do Sistema Nervoso Central/farmacologia
Etanol/efeitos adversos
Etanol/farmacologia
História do Século XX
Seres Humanos
Aptidão Física
Enjoo devido ao Movimento em Voo Espacial
Acuidade Visual/efeitos dos fármacos
Tempo (Meteorologia)
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Central Nervous System Depressants); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1307
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:130530
[St] Status:MEDLINE



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