Base de dados : MEDLINE
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[PMID]:28452711
[Au] Autor:Scott JR; Sowerby LJ; Rotenberg BW
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
[Ti] Título:Office-based rhinologic surgery: A modern experience with operative techniques under local anesthetic.
[So] Source:Am J Rhinol Allergy;31(2):135-138, 2017 Mar 01.
[Is] ISSN:1945-8932
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Office-based rhinologic procedures have become popularized in recent years with the advent of several minimally invasive techniques. There is a paucity of literature, however, that supports more robust in-clinic procedures, e.g., true endoscopic sinus surgery (ESS). There is a high volume of this work being done at our center, and the objective of this article was to review the safety and tolerability of in-clinic surgeries. METHODS: A retrospective chart review was conducted. All the adult patients who underwent in-clinic sinonasal procedures and surgery with a minimum of 3 months of follow-up were included. Information regarding intra- and postoperative complications and revision procedures were recorded. For the ESS procedures, the indication, sinuses operated on, and type of revision were also collected. RESULTS: A total of 315 patients met the inclusion criteria. There were 166 turbinoplasties, 118 ESS, 35 septoplasties, 34 rhinoplasties, and 4 septorhinoplasties performed. For the ESS procedures, 74 (62.7%) were bilateral, and experience was had operating in all paranasal sinuses. All ESS work involved opening diseased ostia and was more than just polypectomies. The mean follow-up for the ESS cases was 13.4 months (range, 12-65 months). Complication rates and tolerability measures were comparable with those of other reported in-office sinonasal procedures performed with the patient under local anesthetic. CONCLUSION: Office-based rhinologic surgery was safe and well tolerated by the patients. The need for revision ESS in our series was low when considering the extent of surgery that was performed. An in-clinic procedure may avoid a general anesthetic in the operating room for appropriately selected patients.
[Mh] Termos MeSH primário: Anestésicos Locais/uso terapêutico
Endoscopia
Obstrução Nasal/epidemiologia
Dor/prevenção & controle
Seios Paranasais/cirurgia
Complicações Pós-Operatórias/prevenção & controle
Rinoplastia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Canadá/epidemiologia
Feminino
Seguimentos
Hospitalização
Seres Humanos
Masculino
Meia-Idade
Procedimentos Cirúrgicos Minimamente Invasivos
Obstrução Nasal/cirurgia
Dor/etiologia
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Local)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.2500/ajra.2017.31.4414


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[PMID]:29364825
[Au] Autor:Strippoli J; Durand R; Schmittbuhl M; Voyer R; Rompré P; Nishio C
[Ad] Endereço:Private Practice of Orthodontics in Tassin-la-Demi-Lune, France.
[Ti] Título:Pain and quality of life in patients undergoing guided piezocorticision- assisted orthodontic treatment.
[So] Source:J Clin Orthod;51(12):792-799, 2017 Dec.
[Is] ISSN:0022-3875
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Ortodontia Corretiva
Dor/etiologia
Piezocirurgia
Qualidade de Vida
[Mh] Termos MeSH secundário: Adolescente
Adulto
Processo Alveolar/cirurgia
Feminino
Seres Humanos
Masculino
Escala Visual Analógica
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE


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[PMID]:28456527
[Au] Autor:Perry J; Towers CV; Weitz B; Wolfe L
[Ad] Endereço:Department of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, University of Tennessee Medical Center, Knoxville, TN, United States.
[Ti] Título:Patient reaction to Tdap vaccination in pregnancy.
[So] Source:Vaccine;35(23):3064-3066, 2017 05 25.
[Is] ISSN:1873-2518
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The current obstetrical recommendation is to routinely administer the tetanus, diphtheria, and acellular pertussis (Tdap) vaccination during every pregnancy regardless of a patient's prior history. There are minimal data that have prospectively evaluated solicited patient response to this treatment plan. The study objective was to evaluate patient reaction following receipt of Tdap vaccination during pregnancy. METHODS: This was a prospective observational study conducted from May 2014 through March 2016. The study design involved solicited patient reaction within 1-7days after the administration of the Tdap vaccine. Data collected included pain or soreness, swelling, and/or redness at the injection site, as well as, fever and generalized body aches. Statistical analysis involved simple percentages with Poisson binomial 95% confidence intervals with Chi-square and Fisher's exact comparisons where appropriate. RESULTS: A total of 737 patients were evaluated and 496 (67%, 95% Confidence Interval [CI] 64-71%) were found to have at least 1 reaction to the vaccination and 187 (25%, 95% CI 22-29%) had 2 reactions or more. Overall, the majority of patients stated that the vaccination was tolerated. However, 24 (3%, 95% CI 2-5%) of the study population stated that they would not accept receipt of Tdap in a subsequent pregnancy because of the response that occurred in the current pregnancy. CONCLUSION: These data demonstrate that maternal reactions following receipt of Tdap are common (two-thirds of the study population). A potential concern is the finding that some patients might refuse a repeat vaccination in a subsequent pregnancy due to these reactions. If further research reveals similar findings, a pertussis only vaccine for pregnant patients might need to be evaluated.
[Mh] Termos MeSH primário: Vacinas contra Difteria, Tétano e Coqueluche Acelular/administração & dosagem
Vacinas contra Difteria, Tétano e Coqueluche Acelular/efeitos adversos
Complicações Infecciosas na Gravidez/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Difteria/prevenção & controle
Feminino
Febre/etiologia
Seres Humanos
Mães/psicologia
Mialgia/etiologia
Dor/etiologia
Gravidez
Estudos Prospectivos
Tétano/prevenção & controle
Vacinação
Coqueluche/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Diphtheria-Tetanus-acellular Pertussis Vaccines)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:29351562
[Au] Autor:Calvet J; Orellana C; Galisteo C; García-Manrique M; Navarro N; Caixàs A; Larrosa M; Gratacós J
[Ad] Endereço:Rheumatology Department, Parc Taulí Sabadell University Hospital. I3PT Research Institute (UAB), Sabadell, Barcelona, Spain.
[Ti] Título:Clinical and ultrasonographic features associated to response to intraarticular corticosteroid injection. A one year follow up prospective cohort study in knee osteoarthritis patient with joint effusion.
[So] Source:PLoS One;13(1):e0191342, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Intraarticular injection is used for pain relief in knee osteoarthritis (OA), but there is not a well defined profile of patient who could get more benefit from it. The purpose of this study was to evaluate the frequency of pain relief at one year after corticosteroids intraarticular injection and to identify clinical factors associated to response in patients with knee osteoarthritis with joint effusion. METHODS: One-year prospective cohort study of patients with knee OA with joint effusion confirmed by ultrasound. An intraarticular injection was performed following a clinical protocol. Anthropometric measurements, laboratory parameters, clinical severity, ultrasound parameters and radiological severity were collected. Response regarding pain and presence of synovial fluid on ultrasound at one month and at one year were evaluated. Clinical responder were consider in subjects with enough improvement to carry out normal daily activities with pain VAS<40mm. RESULTS: One hundred and thirty-two patients were included.A significant number of patients (61.4%) improved pain at one year following the protocol established in this study. Pain and ultrasound synovial fluid at one month appeared to predict the response at one year. The Lequesne index and the percentage of body fat were independently associated to pain at one year while the Lequesne index and ultrasound synovial hypertrophy were independently related to the presence of synovial fluid at one year. CONCLUSIONS: The status regarding pain or ultrasound synovial fluid at one month after an intraarticular joint injection appeared to predict the status at one year in patients with knee osteoarthritis and synovial effusion.
[Mh] Termos MeSH primário: Corticosteroides/administração & dosagem
Osteoartrite do Joelho/tratamento farmacológico
[Mh] Termos MeSH secundário: Idoso
Estudos de Coortes
Feminino
Seguimentos
Seres Humanos
Injeções Intra-Articulares
Masculino
Meia-Idade
Osteoartrite do Joelho/diagnóstico por imagem
Osteoartrite do Joelho/fisiopatologia
Dor/tratamento farmacológico
Manejo da Dor
Medição da Dor
Estudos Prospectivos
Líquido Sinovial/diagnóstico por imagem
Líquido Sinovial/efeitos dos fármacos
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191342


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[PMID]:29295980
[Au] Autor:Barragán-Iglesias P; Lou TF; Bhat VD; Megat S; Burton MD; Price TJ; Campbell ZT
[Ad] Endereço:School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX, 75080, USA.
[Ti] Título:Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice.
[So] Source:Nat Commun;9(1):10, 2018 01 02.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Nociceptors rely on cap-dependent translation to rapidly induce protein synthesis in response to pro-inflammatory signals. Comparatively little is known regarding the role of the regulatory factors bound to the 3' end of mRNA in nociceptor sensitization. Poly(A)-binding protein (PABP) stimulates translation initiation by bridging the Poly(A) tail to the eukaryotic initiation factor 4F complex associated with the mRNA cap. Here, we use unbiased assessment of PABP binding specificity to generate a chemically modified RNA-based competitive inhibitor of PABP. The resulting RNA mimic, which we designated as the Poly(A) SPOT-ON, is more stable than unmodified RNA and binds PABP with high affinity and selectivity in vitro. We show that injection of the Poly(A) SPOT-ON at the site of an injury can attenuate behavioral response to pain. Collectively, these results suggest that PABP is integral for nociceptive plasticity. The general strategy described here provides a broad new source of mechanism-based inhibitors for RNA-binding proteins and is applicable for in vivo studies.
[Mh] Termos MeSH primário: Dor/metabolismo
Poli A/metabolismo
Proteínas de Ligação a Poli(A)/metabolismo
RNA/metabolismo
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Células Cultivadas
Gânglios Espinais/citologia
Seres Humanos
Camundongos
Neurônios/efeitos dos fármacos
Neurônios/metabolismo
Dor Nociceptiva/metabolismo
Dor Nociceptiva/prevenção & controle
Dor/prevenção & controle
Medição da Dor
Poli A/química
Poli A/farmacologia
Proteínas de Ligação a Poli(A)/química
Ligação Proteica
RNA/química
RNA/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Poly(A)-Binding Proteins); 24937-83-5 (Poly A); 63231-63-0 (RNA)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02449-5


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[PMID]:29184406
[Au] Autor:Yuan M; Ding S; Meng T; Lu B; Shao S; Zhang X; Yuan H; Hu F
[Ad] Endereço:Institute of Marine Biology, Ocean College, Zhejiang University, Zhoushan.
[Ti] Título:Effect of A-317491 delivered by glycolipid-like polymer micelles on endometriosis pain.
[So] Source:Int J Nanomedicine;12:8171-8183, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Endometriosis is a common gynecological disease with a lack of effective clinical treatment. Current therapy often results in endometriosis pain recurrence and serious side effects. P2X receptor, an adenosine triphosphate (ATP)-gated ion channel, might be implicated in endometriosis pain. In this study, chitosan oligosaccharide-g-stearic acid (CSOSA) polymer micelles-coated nanostructured lipid carriers (NLCs) were developed as a novel delivery system for A-317491, a selective P2X receptor antagonist for endometriosis pain therapy. A-317491-loaded NLC (NLC/A-317491) could be coated by CSOSA micelles to form CSOSA/NLC/A-317491 nanoparticles. Pheochromocytoma PC12 cells, which highly expressed P2X receptors, were used as a cell model, and the CSOSA/NLC/A-317491 partly blocked the Ca influx induced by ATP stimulation. In nude mouse and rat endometriotic models, CSOSA/NLC could accumulate into endometriotic lesions after vein injection. In endometriotic rats, CSOSA/NLC/A-317491 reversed mechanical and heat hyperalgesia with long-term efficacy, which might be attributed to the massive CSOSA/NLC/A-317491 distribution in the endometriotic lesions. In conclusion, A-317491 delivered by CSOSA/NLC nanoparticles attenuated endometriosis pain in rats, and CSOSA/NLC/A-317491 could be used as an effective treatment strategy for P2X -targeted therapy in endometriosis pain.
[Mh] Termos MeSH primário: Sistemas de Liberação de Medicamentos/métodos
Endometriose/tratamento farmacológico
Nanopartículas/administração & dosagem
Dor/tratamento farmacológico
Fenóis/administração & dosagem
Compostos Policíclicos/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Feminino
Glicolipídeos/química
Seres Humanos
Camundongos Nus
Micelas
Nanopartículas/química
Oligossacarídeos/química
Células PC12
Fenóis/química
Fenóis/farmacologia
Compostos Policíclicos/química
Compostos Policíclicos/farmacologia
Polímeros/química
Antagonistas do Receptor Purinérgico P2X/farmacologia
Ratos
Receptores Purinérgicos P2X3
Ácidos Esteáricos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (A-317491); 0 (Glycolipids); 0 (Micelles); 0 (Oligosaccharides); 0 (Phenols); 0 (Polycyclic Compounds); 0 (Polymers); 0 (Purinergic P2X Receptor Antagonists); 0 (Receptors, Purinergic P2X3); 0 (Stearic Acids); 4ELV7Z65AP (stearic acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S146569


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[PMID]:28460630
[Au] Autor:Moen A; Jacobsen D; Phuyal S; Legfeldt A; Haugen F; Røe C; Gjerstad J
[Ad] Endereço:National Institute of Occupational Health, Pb 8149 Dep., 0033, Oslo, Norway.
[Ti] Título:MicroRNA-223 demonstrated experimentally in exosome-like vesicles is associated with decreased risk of persistent pain after lumbar disc herniation.
[So] Source:J Transl Med;15(1):89, 2017 May 01.
[Is] ISSN:1479-5876
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Previous findings have demonstrated that lumbar radicular pain after disc herniation may be associated with up-regulation of inflammatory mediators. In the present study we examined the possible role of extracellular microRNAs (miRs) in this process. METHODS: Single unit recordings, isolation of exosome-like vesicles, electron microscopy, nanoparticle tracking analysis, western blot analysis and qPCR were used in rats to demonstrate the effect of nucleus pulposus (NP) applied onto the dorsal nerve roots. ELISA and qPCR were used to measure the level of circulating IL-6 and miRs in a 1-year observational study in patients after disc herniation. RESULTS: In the rats, enhanced spinal cord nociceptive responses were displayed after NP applied onto the dorsal nerve roots. An increased release of small non-coding RNAs, including miR-223, miR-760 and miR-145, from NP in exosome-like vesicles was demonstrated. In particular, the NP expression of miR-223, which inhibited the nociceptive spinal signalling, was increased. In the patients, increased extracellular miR-223 was also verified in the acute phase after disc herniation. The increased miR-223 expression was, however, only observed in those who recovered (sex, age and smoking were included as covariates). CONCLUSIONS: Our findings suggest that miR-223, which can be released from the NP after disc herniation, attenuates the neuronal activity in the pain pathways. Dysregulation of miR-223 may predict chronic lumbar radicular pain. Trial registration/ethics REK 2014/1725.
[Mh] Termos MeSH primário: Exossomos/metabolismo
Deslocamento do Disco Intervertebral/complicações
Vértebras Lombares/patologia
MicroRNAs/metabolismo
Dor/etiologia
Dor/genética
[Mh] Termos MeSH secundário: Adulto
Animais
Exossomos/ultraestrutura
Feminino
Seres Humanos
Deslocamento do Disco Intervertebral/patologia
Deslocamento do Disco Intervertebral/fisiopatologia
Vértebras Lombares/fisiopatologia
Masculino
MicroRNAs/genética
Meia-Idade
Ratos Endogâmicos Lew
Recuperação de Função Fisiológica
Fatores de Risco
Regulação para Cima/genética
Escala Visual Analógica
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (MIRN223 microRNA, human); 0 (MIRN223 microRNA, rat); 0 (MicroRNAs)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1186/s12967-017-1194-8


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[PMID]:28449758
[Au] Autor:Brignardello-Petersen R
[Ti] Título:Anxiety related to dental treatment is probably associated with perceived pain, but the magnitude of this association remains unclear.
[So] Source:J Am Dent Assoc;148(5):e54, 2017 05.
[Is] ISSN:1943-4723
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Assistência Odontológica
Dor
[Mh] Termos MeSH secundário: Ansiedade
Ansiedade ao Tratamento Odontológico
Seres Humanos
[Pt] Tipo de publicação:REVIEW; COMMENT
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:28449755
[Au] Autor:Brignardello-Petersen R
[Ti] Título:Reciprocating single-file and multifile rotary instrumentation techniques likely to result in less pain after endodontic treatment of asymptomatic necrotic mandibular molars with periapical lesions.
[So] Source:J Am Dent Assoc;148(5):e51, 2017 05.
[Is] ISSN:1943-4723
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Instrumentos Odontológicos
Dente Molar
[Mh] Termos MeSH secundário: Seres Humanos
Dor
[Pt] Tipo de publicação:REVIEW; COMMENT
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  10 / 116835 MEDLINE  
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[PMID]:28450657
[Au] Autor:Hendarto H; Pramono LA; Harbuwono DS; Yunir E; Subekti I
[Ad] Endereço:Department of Internal Medicine, Faculty of Medicine and Health Science, Syarif Hidayatullah Islamic State University (UIN), Jakarta, Indonesia. hari.hendarto@uinjkt.ac.id.
[Ti] Título:Parathyroid Adenoma in a Young Female Presenting Multiple Fractures and Postoperative Hungry Bone Syndrome.
[So] Source:Acta Med Indones;49(1):69-73, 2017 Jan.
[Is] ISSN:0125-9326
[Cp] País de publicação:Indonesia
[La] Idioma:eng
[Ab] Resumo:A young 18-year-old female patient with general bone pain and history of multiple fractures brought her to our medical attention. Laboratory work showed hypercalcemia and high parathyroid hormone levels in the blood. Radiograph imaging revealed severe scoliosis with multiple vertebrae fractures with decreased bone mineral density. Sestamibi showed parathyroid adenoma. This case emphasizes the importance of maintaining a primary hyperparathyroidism as a differential diagnosis when a young patient presents with a multiple pathologic fractures history.
[Mh] Termos MeSH primário: Adenoma/diagnóstico por imagem
Hormônio Paratireóideo/sangue
Neoplasias das Paratireoides/diagnóstico por imagem
Escoliose/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adenoma/cirurgia
Adolescente
Densidade Óssea
Cálcio/sangue
Diagnóstico Diferencial
Feminino
Fraturas Múltiplas/diagnóstico
Seres Humanos
Hipercalcemia/etiologia
Dor/etiologia
Neoplasias das Paratireoides/cirurgia
Radiografia
Tecnécio Tc 99m Sestamibi
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Parathyroid Hormone); 971Z4W1S09 (Technetium Tc 99m Sestamibi); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE



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