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Pesquisa : C23.888.592.612.860 [Categoria DeCS]
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[Au] Autor:Walter-Nicolet E; Chary-Tardy AC; Tourniaire B; le groupe Pédiadol
[Ad] Endereço:Service de néonatologie-maternité, groupe hospitalier Paris Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France. Electronic address:
[Ti] Título:[Do analgesic sweet solutions in neonates influence glycemia? A literature review].
[Ti] Título:Les solutions sucrées à visée antalgique chez le nouveau-né modifient-elles la glycémie ? Synthèse de la littérature..
[So] Source:Arch Pediatr;24(12):1281-1286, 2017 Dec.
[Is] ISSN:1769-664X
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Sweet solutions are one of the most widely used nonpharmacologic analgesics used for newborns. They alleviate mild to moderate pain induced by painful procedures. They are used daily in neonatal intensive care units before a venepuncture or a heel stick, especially for a blood-sugar measurement. It is agreed that analgesic sweet solutions do not modify glycemia results. This nevertheless remains a recurrent question that the present review attempts to answer.
[Mh] Termos MeSH primário: Analgésicos/administração & dosagem
Glicemia/efeitos dos fármacos
Coleta de Amostras Sanguíneas/efeitos adversos
Dor Processual/prevenção & controle
[Mh] Termos MeSH secundário: Seres Humanos
Dor Processual/etiologia
Flebotomia/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Analgesics); 0 (Blood Glucose); 0 (Solutions); 0 (Sweetening Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE

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[Au] Autor:Sydor RI; Khranovska NM; Skachkova OV; Skivka LM
[Ti] Título:The effect of perioperative analgesic drugs omnopon and dexketoprofen on the functional activity of immune cells in murine model of tumor surgery.
[So] Source:Ukr Biochem J;88(4):40-7, 2016 Jul-Aug.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:We aimed to investigate the effect of perioperative analgesia with nonselective cyclooxygenase-2 inhibitor dexketoprofen and opioid drug omnopon on the functional activity of immune cells in tumor excision murine model. Lewis lung carcinoma cells were transplanted into hind paw of C57/black mice. On the 23th day tumor was removed. Analgesic drugs were injected 30 min before and once a day for 3 days after the surgery. Biological material was obtained a day before, 1 day and 3 days after the tumor removal. IFN-γ, IL-4, IL-10 and TGF-ß mRNA levels in splenic cells were assessed by quantitative real-time RT-PCR. Cytotoxic activity of splenocytes was estimated by flow cytometry. We found that in splenocytes of mice received opioid analgesia IL-10 mRNA level was increased 2.3 times on day one after the surgery compared to preoperative level (P < 0.05), while in dexketoprofen group this parameter did not change. IFN-γ gene expression level on day 3 after tumor removal was 40% higher in splenocytes of dexketoprofen treated mice as compared with omnopon treated animals (P < 0.05). Cytotoxic activity of splenocytes on day 3 postsurgery was (62.2 ± 2.4)% in dexketoprofen against (50.2 ± 3.3)% in omnopon group. In conclusion, perioperative analgesia with cyclooxygenase inhibitor dexketoprofen in contrast to opioid analgesia with omnopon preserves higher functional activity of murine immune cells in the experimental model of tumor surgery.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Carcinoma Pulmonar de Lewis/imunologia
Citotoxicidade Imunológica/efeitos dos fármacos
Linfócitos/efeitos dos fármacos
Dor Processual/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Carcinoma Pulmonar de Lewis/genética
Carcinoma Pulmonar de Lewis/patologia
Carcinoma Pulmonar de Lewis/cirurgia
Expressão Gênica
Membro Posterior
Interferon gama/genética
Interferon gama/imunologia
Cetoprofeno/análogos & derivados
Camundongos Endogâmicos C57BL
Transplante de Neoplasias
Dor Processual/imunologia
Dor Processual/fisiopatologia
Período Perioperatório
RNA Mensageiro/genética
RNA Mensageiro/imunologia
Baço/efeitos dos fármacos
Fator de Crescimento Transformador beta/genética
Fator de Crescimento Transformador beta/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (IL10 protein, mouse); 0 (RNA, Messenger); 0 (Transforming Growth Factor beta); 130068-27-8 (Interleukin-10); 207137-56-2 (Interleukin-4); 8008-60-4 (Opium); 82115-62-6 (Interferon-gamma); 90Y4QC304K (Ketoprofen)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.15407/ubj88.04.040

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[Au] Autor:Monk AB; Harrison JE; Worthington HV; Teague A
[Ad] Endereço:Orthodontic Department, Liverpool University Dental Hospital, Pembroke Place, Liverpool, UK, L3 5PS.
[Ti] Título:Pharmacological interventions for pain relief during orthodontic treatment.
[So] Source:Cochrane Database Syst Rev;11:CD003976, 2017 11 28.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pain is a common side effect of orthodontic treatment. It increases in proportion to the amount of force applied to the teeth, and the type of orthodontic appliance used can affect the intensity of the pain. Pain during orthodontic treatment has been shown to be the most common reason for people wanting to discontinue treatment, and has been ranked as the worst aspect of treatment. Although pharmacological methods of pain relief have been investigated, there remains some uncertainty among orthodontists about which painkillers are most suitable and whether pre-emptive analgesia is beneficial. We conducted this Cochrane Review to assess and summarize the international evidence relating to the effectiveness of analgesics for preventing this unwanted side effect associated with orthodontic treatment. OBJECTIVES: The objectives of this review are to determine:- the effectiveness of drug interventions for pain relief during orthodontic treatment; and- whether there is a difference in the analgesic effect provided by different types, forms and doses of analgesia taken during orthodontic treatment. SEARCH METHODS: Cochrane Oral Health's Information Specialist searched the following databases: the Cochrane Oral Health Trials Register (to 19 June 2017), the Cochrane Central Register of Controlled Trials (CENTRAL;the Cochrane Library 2016, Issue 7), MEDLINE Ovid (1946 to 19 June 2017), Embase Ovid (1980 to 19 June 2017) and CINAHL EBSCO (Cumulative Index to Nursing and Allied Health Literature; 1937 to 19 June 2017). The US National Institutes of Health Ongoing Trials Register ( and the World Health Organization International Clinical Trials Registry Platform were searched on the 19 June 2017 for ongoing studies. We placed no restrictions on language or date of publication when searching the electronic databases. SELECTION CRITERIA: We included randomized controlled trials (RCTs) relating to pain control during orthodontic treatment. Pain could be measured on a visual analogue scale (VAS), numerical rating scale (NRS) or categorical scale. DATA COLLECTION AND ANALYSIS: Two review authors independently screened the search results, agreed the studies to be included and extracted information from the included studies regarding methods, participants, interventions, outcomes, harms and results. We planned to resolve any discrepancies or disagreements through discussion. We used the Cochrane 'Risk of bias' tool to assess the risk of bias in the studies. MAIN RESULTS: We identified 32 relevant RCTs, which included 3110 participants aged 9 to 34 years, 2348 of whom we were able to include in our analyses. Seventeen of the studies had more than two arms. We were able to use data from 12 trials in meta-analyses that compared analgesics versus control (no treatment or a placebo); nine that compared non-steroidal anti-inflammatories (NSAIDs) versus paracetamol; and two that compared pre-emptive versus post-treatment ibuprofen for pain control following orthodontic treatment. One study provided data for the comparison of NSAIDs versus local anaesthetic.We found moderate-quality evidence that analgesics effectively reduced pain following orthodontic treatment when compared to no treatment or a placebo at 2 hours (mean difference (MD) -11.66 mm on a 0 to 100 mm VAS, 95% confidence interval (CI) -16.15 to -7.17; 10 studies, 685 participants), 6 hours (MD -24.27 mm on a VAS, 95% CI -31.44 to -17.11; 9 studies, 535 participants) and 24 hours (MD -21.19 mm on a VAS, 95% CI -28.31 to -14.06; 12 studies, 1012 participants).We did not find any evidence of a difference in efficacy between NSAID and paracetamol at 2, 6 or 24 hours (at 24 hours: MD -0.51, 95% CI -8.93 to 7.92; 9 studies, 734 participants; low-quality evidence).Very low-quality evidence suggested pre-emptive ibuprofen gave better pain relief at 2 hours than ibuprofen taken post treatment (MD -11.30, 95% CI -16.27 to -6.33; one study, 41 participants), however, the difference was no longer significant at 6 or 24 hours.A single study of 48 participants compared topical NSAIDs versus local anaesthetic and showed no evidence of a difference in the effectiveness of the interventions (very low-quality evidence).Use of rescue analgesia was poorly reported. The very low-quality evidence did not show evidence of a difference between participants taking ibuprofen and participants taking paracetamol (relative risk (RR) 1.5, 95% CI 0.6 to 3.6). Nor did we find evidence of a difference between groups in likelihood of requiring rescue analgesia when ibuprofen was taken pre-emptively compared to after treatment (RR 0.8, 95% CI 0.3 to 1.9).Adverse effects were identified in one study, with one participant developing a rash that required treatment with antihistamines. This was provisionally diagnosed as a hypersensitivity to paracetamol. AUTHORS' CONCLUSIONS: Analgesics are more effective at reducing pain following orthodontic treatment than placebo or no treatment. Low-quality evidence did not show a difference in effectiveness between systemic NSAIDs compared with paracetamol, or topical NSAIDs compared with local anaesthetic. More high-quality research is needed to investigate these comparisons, and to evaluate pre-emptive versus post-treatment administration of analgesics.
[Mh] Termos MeSH primário: Analgésicos/uso terapêutico
Ortodontia Corretiva/efeitos adversos
Dor Processual/tratamento farmacológico
[Mh] Termos MeSH secundário: Acetaminofen/uso terapêutico
Analgésicos não Entorpecentes/uso terapêutico
Anestésicos Locais/uso terapêutico
Anti-Inflamatórios não Esteroides/uso terapêutico
Seres Humanos
Medição da Dor
Dor Processual/etiologia
Dor Processual/prevenção & controle
Ensaios Clínicos Controlados Aleatórios como Assunto
[Nm] Nome de substância:
0 (Analgesics); 0 (Analgesics, Non-Narcotic); 0 (Anesthetics, Local); 0 (Anti-Inflammatory Agents, Non-Steroidal); 362O9ITL9D (Acetaminophen)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD003976.pub2

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