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  1 / 1219 MEDLINE  
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[PMID]:28742057
[Au] Autor:Gonçalves MLL; Kalil Bussadori S; Dadalti Fragoso Y; da Silva VVB; Melo Deana A; da Mota ACC; Horácio Pinto E; Horliana ACR; Miranda França C
[Ad] Endereço:Postgraduate Program on Biophotonics Applied to Health Sciences, Nove de Julho University, Vergueiro Street, 235/249, Liberdade, ZIP 01504-001, São Paulo, SP, Brazil.
[Ti] Título:Effect of photodynamic therapy in the reduction of halitosis in patients with multiple sclerosis: clinical trial.
[So] Source:J Breath Res;11(4):046006, 2017 Oct 27.
[Is] ISSN:1752-7163
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Smell and odours play a vital role in social interaction. Halitosis is a social problem that affects one third of the population, causing a negative impact on the quality of life. There is little knowledge on the prevalence and management of halitosis in multiple sclerosis (MS) patients. The present study aims to evaluate the presence of halitosis in patients with MS when compared to a control group, and also evaluate treatment of the problem with antimicrobial photodynamic therapy (aPDT). This is a case-control clinical study in which 60 patients were evaluated: 30 MS patients in treatment at the Specialties Clinic School of Medicine, and 30 healthy patients, matched in age and gender for the control group. Data was collected on the duration of the disease as well as the degree of disability and medication use in the MS group. For all patients, halitosis was assessed with Oral Chroma™. Individuals with halitosis underwent treatment with tongue scraping and aPDT. The photosensitizer was methylene blue (0.005%) and a THERAPY XT-EC laser (660 nm, 9 J, 100 mW for 90 s per point, 320 J cm , 3537 mW cm ) was used. Six points 1 cm apart from each other were irradiated in the tongue dorsum. There was a positive correlation between the disability and disease duration. No parameter was correlated with halitosis. Patients with MS have higher levels of SH compounds when compared to the control group (p = 0.003, Mann-Whitney), but after aPDT both groups significantly reduced the levels to under the halitosis threshold. The aPDT scraping treatment was effective in the immediate reduction of halitosis in both groups.
[Mh] Termos MeSH primário: Halitose/complicações
Halitose/tratamento farmacológico
Esclerose Múltipla/complicações
Fotoquimioterapia
[Mh] Termos MeSH secundário: Adulto
Idoso
Anti-Infecciosos/uso terapêutico
Testes Respiratórios
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Azul de Metileno/uso terapêutico
Meia-Idade
Fármacos Fotossensibilizantes/uso terapêutico
Qualidade de Vida
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Photosensitizing Agents); T42P99266K (Methylene Blue)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1088/1752-7163/aa8209


  2 / 1219 MEDLINE  
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[PMID]:28609410
[Au] Autor:Oh KE; Song AR; Sok SR
[Ad] Endereço:Department of Nursing, Graduate School, Kyung Hee University, Seoul, Republic of Korea (Mss Oh and Song); and College of Nursing Science, Kyung Hee University, Seoul, Republic of Korea (Dr Sok).
[Ti] Título:Effects of Aroma Gargling, Cold Water Gargling, and Wet Gauze Application on Thirst, Halitosis, and Sore Throat of Patients After Spine Surgery.
[So] Source:Holist Nurs Pract;31(4):253-259, 2017 Jul/Aug.
[Is] ISSN:1550-5138
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study compared and examined the effects of aroma gargling, cold water gargling, and wet gauze application on thirst, halitosis, and sore throat in patients after spine surgery. A quasiexperimental pretest/posttest control group design was employed. Samples were total 70 patients (aroma gargling: 24 samples, cold gargling: 24 samples, and wet gauze: 22 samples) after spine surgery in K Hospital in Seoul, Korea. The aroma gargle solution as an experimental intervention was prepared by blending peppermint, tea tree, and lemon oils at a ratio of 1:2:2. A 60 cc of aroma gargle solution was used 3 times for 15 to 20 seconds. The visual analog scale was used to measure the degrees of thirst and sore throat, and a portable device was used to examine the degree of halitosis. There were significant differences in the degrees of thirst, halitosis, and sore throat according to interaction between group and duration. In the comparison among 3 groups, aroma gargling provided better oral health by decreasing thirst, halitosis, and sore throat for patients with spine surgery. Aroma gargling can be utilized as an effective nursing intervention for decreasing thirst, halitosis, and sore throat for patients with spine surgery in clinical practice. Results suggest, therefore, that health professionals should consider an array of methods including aroma gargling for patients after spine surgery.
[Mh] Termos MeSH primário: Antissépticos Bucais/farmacologia
Antissépticos Bucais/normas
Procedimentos Ortopédicos/enfermagem
Complicações Pós-Operatórias/terapia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Halitose/enfermagem
Seres Humanos
Masculino
Antissépticos Bucais/uso terapêutico
Náusea/prevenção & controle
Náusea/terapia
Procedimentos Ortopédicos/estatística & dados numéricos
Faringite/enfermagem
República da Coreia
Coluna Vertebral/cirurgia
Inquéritos e Questionários
Sede
Vômito/prevenção & controle
Vômito/terapia
Água/administração & dosagem
Água/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mouthwashes); 059QF0KO0R (Water)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE
[do] DOI:10.1097/HNP.0000000000000219


  3 / 1219 MEDLINE  
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[PMID]:28319129
[Au] Autor:Nani BD; Lima PO; Marcondes FK; Groppo FC; Rolim GS; Moraes AB; Cogo-Müller K; Franz-Montan M
[Ad] Endereço:Department of Physiological Sciences, Piracicaba Dental School, University of Campinas-UNICAMP, Piracicaba, SP, Brazil.
[Ti] Título:Changes in salivary microbiota increase volatile sulfur compounds production in healthy male subjects with academic-related chronic stress.
[So] Source:PLoS One;12(3):e0173686, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate the associations among salivary bacteria, oral emanations of volatile sulfur compounds, and academic-related chronic stress in healthy male subjects. MATERIALS AND METHODS: Seventy-eight healthy male undergraduate dental students were classified as stressed or not by evaluation of burnout, a syndrome attributed to academic-related chronic stress. This evaluation was carried out using the Maslach Burnout Inventory-Student Survey questionnaire. Oral emanations of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide were measured using an Oral Chroma™ portable gas chromatograph. The amounts in saliva of total bacteria and seven bacteria associated with halitosis were quantified by qPCR. The in vitro production of H2S by S. moorei and/or F. nucleatum was also measured with the Oral Chroma™ instrument. RESULTS: The stressed students group showed increased oral emanations of hydrogen sulfide and dimethyl sulfide, together with higher salivary Solobacterium moorei levels (p < 0.05, Mann Whitney test). There were moderate positive correlations between the following pairs of variables: Fusobacterium nucleatum and S. moorei; F. nucleatum and hydrogen sulfide; Tannerella forsythia and F. nucleatum; T. forsythia and S. moorei. These correlations only occurred for the stressed group (p < 0.05, Spearman correlation). The in vitro experiment demonstrated that S. moorei increased H2S production by F. nucleatum (p < 0.05, ANOVA and Tukey's test). CONCLUSION: The increased amount of S. moorei in saliva, and its coexistence with F. nucleatum and T. forsythia, seemed to be responsible for increased oral hydrogen sulfide in the healthy male stressed subjects.
[Mh] Termos MeSH primário: Voluntários Saudáveis
Saliva/microbiologia
Estresse Psicológico/microbiologia
Estudantes/psicologia
Compostos de Enxofre/química
Compostos de Enxofre/metabolismo
[Mh] Termos MeSH secundário: Adolescente
Bactérias/metabolismo
Halitose/microbiologia
Seres Humanos
Masculino
Volatilização
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfur Compounds)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173686


  4 / 1219 MEDLINE  
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[PMID]:28292323
[Au] Autor:Tsuruta M; Takahashi T; Tokunaga M; Iwasaki M; Kataoka S; Kakuta S; Soh I; Awano S; Hirata H; Kagawa M; Ansai T
[Ad] Endereço:Division of Community Oral Health Development, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu, 803-8580, Japan.
[Ti] Título:Relationships between pathologic subjective halitosis, olfactory reference syndrome, and social anxiety in young Japanese women.
[So] Source:BMC Psychol;5(1):7, 2017 Mar 14.
[Is] ISSN:2050-7283
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pathologic subjective halitosis is known as a halitosis complaint without objective confirmation of halitosis by others or by halitometer measurements; it has been reported to be associated with social anxiety disorder. Olfactory reference syndrome is a preoccupation with the false belief that one emits a foul and offensive body odor. Generally, patients with olfactory reference syndrome are concerned with multiple body parts. However, the mouth is known to be the most common source of body odor for those with olfactory reference syndrome, which could imply that the two conditions share similar features. Therefore, we investigated potential causal relationships among pathologic subjective halitosis, olfactory reference syndrome, social anxiety, and preoccupations with body part odors. METHODS: A total of 1360 female students (mean age 19.6 ± 1.1 years) answered a self-administered questionnaire regarding pathologic subjective halitosis, olfactory reference syndrome, social anxiety, and preoccupation with odors of body parts such as mouth, body, armpits, and feet. The scale for pathologic subjective halitosis followed that developed by Tsunoda et al.; participants were divided into three groups based on their scores (i.e., levels of pathologic subjective halitosis). A Bayesian network was used to analyze causal relationships between pathologic subjective halitosis, olfactory reference syndrome, social anxiety, and preoccupations with body part odors. RESULTS: We found statistically significant differences in the results for olfactory reference syndrome and social anxiety among the various levels of pathologic subjective halitosis (P < 0.001). Residual analyses indicated that students with severe levels of pathologic subjective halitosis showed greater preoccupations with mouth and body odors (P < 0.05). Bayesian network analysis showed that social anxiety directly influenced pathologic subjective halitosis and olfactory reference syndrome. Preoccupations with mouth and body odors also influenced pathologic subjective halitosis. CONCLUSIONS: Social anxiety may be a causal factor of pathologic subjective halitosis and olfactory reference syndrome.
[Mh] Termos MeSH primário: Transtornos de Ansiedade/psicologia
Halitose/psicologia
Percepção Olfatória/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Autoavaliação Diagnóstica
Feminino
Seres Humanos
Japão
Odorantes
Inquéritos e Questionários
Síndrome
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1186/s40359-017-0176-1


  5 / 1219 MEDLINE  
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[PMID]:28212110
[Au] Autor:Muniz FW; Friedrich SA; Silveira CF; Rösing CK
[Ti] Título:The impact of chewing gum on halitosis parameters: a systematic review.
[So] Source:J Breath Res;11(1):014001, 2017 02 17.
[Is] ISSN:1752-7163
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study aimed to analyze the impact of chewing gum on halitosis parameters. Three databases were searched with the following focused question: 'Can chewing gum additionally reduce halitosis parameters, such as organoleptic scores and volatile sulfur compounds (VSC), when compared to a control treatment'? Controlled clinical trials presenting at least two halitosis measurements (organoleptic scores and/or VSC) were included. Ten studies were included, and different active ingredients were used. One study was performed using a chewing gum without any active ingredient. Chewing gum containing probiotic bacterium was shown to significantly reduce the organoleptic scores. Chewing gums containing zinc acetate and magnolia bark extract as well as allylisothiocyanate (AITC) with zinc lactate significantly reduced the levels of VSC in comparison to a placebo chewing gum. Furthermore, a sodium bicarbonate-containing chewing gum significantly reduced the VSC levels in comparison to rinsing with water. Furthermore, eucalyptus-extract chewing gum showed significant reductions in both organoleptic scores and VSC when compared with a control chewing gum. Chewing gum containing sucrose was able to reduce the VSC levels, in comparison to xylitol and zinc citrate chewing gum, but only for 5 min. It was concluded that chewing gums containing probiotics Lactobaccilus, zinc acetate and magnolia bark extract, eucalyptus-extract, and AITC with zinc lactate may be suitable for halitosis management. However, the low number of included studies and the high heterogeneity among the selected studies may limit the clinical applications of these findings.
[Mh] Termos MeSH primário: Goma de Mascar
Halitose/terapia
[Mh] Termos MeSH secundário: Testes Respiratórios
Seres Humanos
Viés de Publicação
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chewing Gum)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171112
[Lr] Data última revisão:
171112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.1088/1752-7163/aa5cc2


  6 / 1219 MEDLINE  
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[PMID]:27840370
[Au] Autor:Yoshino K; Suzuki S; Ishizuka Y; Takayanagi A; Sugihara N; Kamijyo H
[Ad] Endereço:Department of Epidemiology and Public Health, Tokyo Dental College, Japan.
[Ti] Título:Relationship between job stress and subjective oral health symptoms in male financial workers in Japan.
[So] Source:Ind Health;55(2):119-126, 2017 Apr 07.
[Is] ISSN:1880-8026
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim was to assess subjective oral health symptoms and job stress, as measured by self-assessment of how demanding the job is, in male financial workers. METHODS: The participants were recruited by applying screening procedures to a pool of Japanese registrants in an online database. For the stress check, 7 items about how demanding the job is were selected from The Brief Job Stress Questionnaire (BJSQ). Participants comprised a total of 950 financial male workers, ages 25 to 64. RESULTS: Participants who answered "I can't complete my work in the required time" had more decayed teeth (p=0.010). Participants who felt that their job is highly demanding (answered affirmatively to 6 or all 7 items) were more likely to report "often get food stuck between teeth" (p=0.030), "there are some foods I can't eat" (p=0.005), "bad breath" (p=0.032), and "jaw makes clicking sound" (p=0.032). The independent variable of total stress score of 24-28 was found to be correlated to at least three oral health symptoms (OR: 3.25; 95%CI: 1.66-6.35). CONCLUSION: These results indicate that certain job stress factors are associated with certain oral health symptoms, and that oral health symptoms are likely predictors of job stress.
[Mh] Termos MeSH primário: Emprego/psicologia
Saúde do Trabalhador
Saúde Bucal
Estresse Psicológico/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Cárie Dentária/epidemiologia
Halitose/epidemiologia
Seres Humanos
Japão/epidemiologia
Doenças Maxilomandibulares/epidemiologia
Masculino
Meia-Idade
Estresse Psicológico/psicologia
Carga de Trabalho
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161115
[St] Status:MEDLINE
[do] DOI:10.2486/indhealth.2016-0120


  7 / 1219 MEDLINE  
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[PMID]:28076463
[Au] Autor:Graziano TS; Calil CM; Sartoratto A; Franco GC; Groppo FC; Cogo-Müller K
[Ad] Endereço:- Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba, Área de Microbiologia e Imunologia, Departamento de Diagnóstico Oral, Piracicaba, SP, Brasil.
[Ti] Título:In vitro effects of Melaleuca alternifolia essential oil on growth and production of volatile sulphur compounds by oral bacteria.
[So] Source:J Appl Oral Sci;24(6):582-589, 2016 Nov-Dec.
[Is] ISSN:1678-7765
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Objective: Halitosis can be caused by microorganisms that produce volatile sulphur compounds (VSCs), which colonize the surface of the tongue and subgingival sites. Studies have reported that the use of natural products can reduce the bacterial load and, consequently, the development of halitosis. The aim of this study was to evaluate the antimicrobial activity of the essential oil of Melaleuca alternifolia on the growth and volatile sulphur compound (VSC) production of oral bacteria compared with chlorhexidine. Material and Methods: The effects of these substances were evaluated by the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) in planktonic cultures of Porphyromonas gingivalis and Porphyromonas endodontalis. In addition, gas chromatography analyses were performed to measure the concentration of VSCs from bacterial cultures and to characterize M. alternifolia oil components. Results: The MIC and MBC values were as follows: M. alternifolia - P. gingivalis (MIC and MBC=0.007%), P. endodontalis (MIC and MBC=0.007%=0.5%); chlorhexidine - P. gingivalis and P. endodontalis (MIC and MBC=1.5 mg/mL). M. alternifolia significantly reduced the growth and production of hydrogen sulfide (H2S) by P. gingivalis (p<0.05, ANOVA-Dunnet) and the H2S and methyl mercaptan (CH3SH) levels of P. endodontalis (p<0.05, ANOVA-Dunnet). Chlorhexidine reduced the growth of both microorganisms without altering the production of VSC in P. endodontalis. For P. gingivalis, the production of H2S and CH3SH decreased (p<0.05, ANOVA-Dunnet). Conclusion: M. alternifolia can reduce bacterial growth and VSCs production and could be used as an alternative to chlorhexidine.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Melaleuca/química
Porphyromonas endodontalis/efeitos dos fármacos
Porphyromonas gingivalis/efeitos dos fármacos
Compostos de Enxofre/metabolismo
Óleo de Melaleuca/farmacologia
[Mh] Termos MeSH secundário: Análise de Variância
Carga Bacteriana/efeitos dos fármacos
Células Cultivadas
Cromatografia Gasosa-Espectrometria de Massas
Halitose/metabolismo
Halitose/microbiologia
Halitose/prevenção & controle
Testes de Sensibilidade Microbiana
Porphyromonas endodontalis/crescimento & desenvolvimento
Porphyromonas endodontalis/metabolismo
Porphyromonas gingivalis/crescimento & desenvolvimento
Porphyromonas gingivalis/metabolismo
Reprodutibilidade dos Testes
Compostos de Enxofre/análise
Fatores de Tempo
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Sulfur Compounds); 68647-73-4 (Tea Tree Oil)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170430
[Lr] Data última revisão:
170430
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE


  8 / 1219 MEDLINE  
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[PMID]:27966509
[Au] Autor:Sheikh FS; Iyer RR
[Ad] Endereço:Department of Public Health Dentistry, K.M. Shah Dental College and Hospital, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.
[Ti] Título:The effect of oil pulling with rice bran oil, sesame oil, and chlorhexidine mouth rinsing on halitosis among pregnant women: A comparative interventional study.
[So] Source:Indian J Dent Res;27(5):508-512, 2016 Sep-Oct.
[Is] ISSN:1998-3603
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Rice bran oil, owing to its potential antioxidant benefits, could be an effective and novel alternative to sesame oil for oil pulling. As it is safe and a growingly popular edible oil, it may be acceptable during pregnancy, especially in the Indian context where women may be hesitant to use chemical plaque control methods for preventing halitosis. AIMS: The present study was conducted to compare the effects of oil pulling with rice bran oil, oil pulling with sesame oil, and oil pulling with chlorhexidine mouth rinsing on reducing halitosis among pregnant women. SETTINGS AND DESIGN: Thirty pregnant women who attended the Gynecology Outpatient Department (OPD) of Muslim Medical Hospital, Haran Khana Road, Pani Gate, Vadodara, Gujarat, India, were recruited in the present randomized double-blind interventional study. SUBJECTS AND METHODS: Eligible pregnant women individuals who gave consent for the study were randomly allocated to receive the interventions under investigation. Halitosis was measured at baseline and after 14 days of intervention using TANITA breath checker HC-212M-BL. STATISTICAL ANALYSIS USED: Data entry was done in Microsoft Excel 2007, and statistical analysis was performed using SPSS version 17. Wilcoxon signed rank tests were used to interpret the differences in baseline and postintervention halitosis levels. One-way ANOVA was done to compare the mean reduction in halitosis scores of the three intervention groups. RESULTS: There was a statistically significant reduction in the grades of halitosis at baseline and 14 days after intervention for all the three groups. There was no statistically significant difference between chlorhexidine mouth rinsing, oil pulling with sesame oil, and oil pulling with rice bran oil in halitosis reduction. CONCLUSIONS: Rice bran oil when used in oil pulling was effective in reducing halitosis. It performed comparably and marginally superior to other agents tested in the study when change in halitosis postintervention was considered.
[Mh] Termos MeSH primário: Clorexidina/uso terapêutico
Halitose/complicações
Antissépticos Bucais/uso terapêutico
Óleos Vegetais/uso terapêutico
Complicações na Gravidez/tratamento farmacológico
Óleo de Gergelim/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Método Duplo-Cego
Feminino
Halitose/tratamento farmacológico
Seres Humanos
Gravidez
Óleo de Farelo de Arroz
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Mouthwashes); 0 (Plant Oils); 8008-74-0 (Sesame Oil); LZO6K1506A (Rice Bran Oil); R4KO0DY52L (Chlorhexidine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:161215
[St] Status:MEDLINE
[do] DOI:10.4103/0970-9290.195638


  9 / 1219 MEDLINE  
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[PMID]:27869109
[Au] Autor:Jeffet U; Nasrallah R; Sterer N
[Ad] Endereço:Sackler Faculty of Medicine, Department of Prosthodontics, Goldschleger School of Dental Medicine, Tel-Aviv University, Ramat-Aviv 6997801, Israel.
[Ti] Título:Effect of red dyes on blue light phototoxicity against VSC producing bacteria in an experimental oral biofilm.
[So] Source:J Breath Res;10(4):046011, 2016 11 21.
[Is] ISSN:1752-7163
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Oral malodour is considered to be caused mainly by the production of volatile sulfide compounds (VSC) by anaerobic Gram-negative oral bacteria. Previous study showed that these bacteria were susceptible to blue light (wavelengths of 400-500 nm). In the present study, we tested the effect of blue light in the presence of red dyes on malodour production in an experimental oral biofilm. Biofilms were exposed to a plasma-arc light source for 30, 60, and 120 s (i.e. fluences of 41, 82, and 164 J cm , respectively) with the addition of erythrosine, natural red and rose bengal (0.01, 0.1 and 1% w/v). Following light exposure biofilm samples were examined for malodour production (Odour judge), VSC production (Halimeter ), VSC producing bacteria quantification using microscopy sulfide assay (MSA) and reactive oxygen species (ROS) production. Results showed that the exposure of experimental oral biofilm to blue light in the presence of rose bengal caused an increased reduction in VSC and malodour production concomitant with an increase in ROS production. These results suggest that rose bengal might be effective as a blue light photosensitizer against VSC producing bacteria.
[Mh] Termos MeSH primário: Bactérias/crescimento & desenvolvimento
Biofilmes/efeitos dos fármacos
Corantes/metabolismo
Dermatite Fototóxica/metabolismo
Halitose/microbiologia
Luz
Sulfetos/metabolismo
[Mh] Termos MeSH secundário: Testes Respiratórios
Seres Humanos
Fármacos Fotossensibilizantes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coloring Agents); 0 (Photosensitizing Agents); 0 (Sulfides)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161122
[St] Status:MEDLINE


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Fotocópia
[PMID]:27753430
[Au] Autor:Rai M; Spratt D; Gomez-Pereira PR; Patel J; Nair SP
[Ad] Endereço:Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK.
[Ti] Título:Light activated antimicrobial agents can inactivate oral malodour causing bacteria.
[So] Source:J Breath Res;10(4):046009, 2016 10 18.
[Is] ISSN:1752-7163
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Oral malodour is a common condition which affects a large proportion of the population, resulting in social, emotional and psychological stress. Certain oral bacteria form a coating called a biofilm on the tongue dorsum and degrade organic compounds releasing volatile sulfur compounds that are malodourous. Current chemical treatments for oral malodour such as mouthwashes containing chlorhexidine or essential oils, are not sufficiently effective at reducing the bacterial load on the tongue. One potential alternative to current chemical treatments for oral malodour is the use of light activated antimicrobial agents (LAAAs), which display no toxicity or antimicrobial activity in the dark, but when exposed to light of a specific wavelength produce reactive oxygen species which induce damage to target cells in a process known as photodynamic inactivation. This study aimed to determine whether oral malodour causing bacteria were susceptible to lethal photosensitization. Five bacterial species that are causative agents of oral malodour were highly sensitive to lethal photosensitization and were efficiently killed by methylene blue in conjunction with 665 nm laser light. Between 4.5-5 log reductions in the number of viable bacteria were achieved with 20 µM methylene blue and 14.53 J cm laser light for Porphyromonas gingivalis, Prevotella intermedia, Peptostreptococcus anaerobius and Solobacterium moorei. The number of viable cells fell below the limit of detection in the case of Fusobacterium nucleatum. These findings demonstrate that methylene blue in combination with 665 nm laser light is effective at killing bacteria associated with oral malodour, suggesting photodynamic therapy could be a viable treatment option for oral malodour.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Bactérias Gram-Negativas/efeitos dos fármacos
[Mh] Termos MeSH secundário: Biofilmes/efeitos dos fármacos
Relação Dose-Resposta a Droga
Bactérias Gram-Negativas/efeitos da radiação
Halitose/microbiologia
Seres Humanos
Azul de Metileno/farmacologia
Fotoquimioterapia
Fármacos Fotossensibilizantes/farmacologia
Porphyromonas gingivalis/efeitos dos fármacos
Porphyromonas gingivalis/efeitos da radiação
Língua/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Photosensitizing Agents); T42P99266K (Methylene Blue)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170404
[Lr] Data última revisão:
170404
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161019
[St] Status:MEDLINE



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