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[PMID]:29419660
[Au] Autor:Kim JE; Lee MK; Lee DK; Choi SS; Park JS
[Ad] Endereço:Department of Anesthesiology and Pain medicine, Korea University, Guro Hospital, Seoul, Republic of Korea.
[Ti] Título:Continuous cervical epidural block: Treatment for intractable hiccups.
[So] Source:Medicine (Baltimore);97(6):e9444, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Intractable hiccups, although rare, may result in severe morbidity, including sleep deprivation, poor food intake, respiratory muscle fatigue, aspiration pneumonia, and death. Despite these potentially fatal complications, the etiology of intractable hiccups and definitive treatment are unknown. This study aimed to evaluate the effectiveness of continuous cervical epidural block in the treatment of intractable hiccups.Records from 28 patients with a history of unsuccessful medical and invasive treatments for hiccups were evaluated. Continuous cervical epidural block was performed with a midline approach at the C7-T1 or T1-T2 intervertebral space with the patient in the prone position. The epidural catheter was advanced through the needle in a cephalad direction to the C3-C5 level. Catheter placement was confirmed using contrast radiography. A 6-mL bolus of 0.25% ropivacaine was injected, and a continuous infusion of 4 mL/h of ropivacaine was administered through the epidural catheter using an infuser containing 0.75% ropivacaine (45 mL ropivacaine and 230 mL normal saline). When the hiccups stopped and did not recur for 48 hours, the catheter was removed.Cumulative complete remission rates were 60.71% after the first cervical epidural block, 92.86% after the second, and 100% after the third. One patient complained of dizziness that subsided. No other adverse effects were reported.Continuous C3-C5 level cervical epidural block has a successful remission rate. We suggest that continuous cervical epidural block is an effective treatment for intractable hiccups.
[Mh] Termos MeSH primário: Amidas/administração & dosagem
Bloqueio Nervoso Autônomo
Soluço
Injeções Epidurais/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Anestésicos Locais/administração & dosagem
Bloqueio Nervoso Autônomo/efeitos adversos
Bloqueio Nervoso Autônomo/métodos
Cateterismo/métodos
Medula Cervical/efeitos dos fármacos
Medula Cervical/fisiopatologia
Tontura/etiologia
Feminino
Soluço/diagnóstico
Soluço/fisiopatologia
Soluço/terapia
Seres Humanos
Masculino
Meia-Idade
Recidiva
Indução de Remissão/métodos
República da Coreia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amides); 0 (Anesthetics, Local); 7IO5LYA57N (ropivacaine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009444


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[PMID]:28455489
[Au] Autor:Zhang F; Tongo ND; Hastings V; Kanzali P; Zhu Z; Chadow H; Rafii SE
[Ad] Endereço:Department of Internal Medicine, Brookdale University Hospital and Medical Center, Brooklyn, NY, USA.
[Ti] Título:ST-Segment Elevation Myocardial Infarction with Acute Stent Thrombosis Presenting as Intractable Hiccups: An Unusual Case.
[So] Source:Am J Case Rep;18:467-471, 2017 Apr 29.
[Is] ISSN:1941-5923
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Acute coronary syndrome (ACS) can present with atypical chest pain or symptoms not attributed to heart disease, such as indigestion. Hiccups, a benign and self-limited condition, can become persistent or intractable with overlooked underlying etiology. There are various causes of protracted hiccups, including metabolic abnormalities, psychogenic disorders, malignancy, central nervous system pathology, medications, pulmonary disorders, or gastrointestinal etiologies. It is rarely attributed to cardiac disease. CASE REPORT We report a case of intractable hiccups in a 51-year-old male with cocaine related myocardial infarction (MI) before and after stent placement. Coronary angiogram showed in-stent thrombosis of the initial intervention. Following thrombectomy, balloon angioplasty, and stent, the patient recovered well without additional episodes of hiccups. Although hiccups are not known to present with a predilection for a particular cause of myocardial ischemia, this case may additionally be explained by the sympathomimetic effects of cocaine, which lead to vasoconstriction of coronary arteries. CONCLUSIONS Hiccups associated with cardiac enzyme elevation and EKG ST-segment elevation before and after percutaneous coronary intervention (PCI) maybe a manifestation of acute MI with or without stent. The fact that this patient was a cocaine user may have contributed to the unique presentation.
[Mh] Termos MeSH primário: Trombose Coronária/complicações
Soluço/etiologia
Infarto do Miocárdio com Supradesnível do Segmento ST/etiologia
Stents/efeitos adversos
[Mh] Termos MeSH secundário: Transtornos Relacionados ao Uso de Cocaína/complicações
Trombose Coronária/diagnóstico
Trombose Coronária/etiologia
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:28759492
[Au] Autor:Kohse EK; Hollmann MW; Bardenheuer HJ; Kessler J
[Ad] Endereço:From the Department of Anesthesiology, Pain Therapy Unit, University Hospital Heidelberg, Heidelberg, Germany.
[Ti] Título:Chronic Hiccups: An Underestimated Problem.
[So] Source:Anesth Analg;125(4):1169-1183, 2017 Oct.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Persistent singultus, hiccupping that lasts for longer than 48 hours, can have a tremendous impact on a patient's quality of life. Although involved neurologic structures have been identified, the function of hiccups remains unclear-they have been controversially interpreted as a primitive reflex preventing extent swallowing of amniotic fluid in utero, an archaic gill ventilation pattern, or a fetus' preparation for independent breathing. Persistent singultus often presents as a symptom for various diseases, most commonly illnesses of the central nervous system or gastrointestinal tract; they can also be evoked by a variety of pharmacological agents. It is often impossible to define a singular cause. A wide range of treatment attempts, pharmacological and nonpharmacological, have been concerted to this date; however, chlorpromazine remains the only Food and Drug Administration-approved drug in this context. Large-scale studies on efficacy and tolerance of other therapeutic strategies are lacking. Gabapentin, baclofen, and metoclopramide have been reported to accomplish promising results in reports on the therapy of persistent singultus; they may also be effective when given in combination with other drugs, eg, proton pump inhibitors, or as conjoined therapy. As another approach of note, acupuncture treatment was able to abolish hiccups in a number of studies. When managing hiccup patients within the clinical routine, it is of importance to conduct a comprehensive and effective diagnostic workup; a well-functioning interdisciplinary team is needed to address possible causes for the symptom. Persistent singultus is a medical problem not to be underestimated; more research on options for effective treatment would be greatly needed.
[Mh] Termos MeSH primário: Anestesiologia/métodos
Soluço/complicações
Soluço/diagnóstico
[Mh] Termos MeSH secundário: Aminas/uso terapêutico
Baclofeno/uso terapêutico
Doença Crônica
Ácidos Cicloexanocarboxílicos/uso terapêutico
Soluço/tratamento farmacológico
Seres Humanos
Relaxantes Musculares Centrais/uso terapêutico
Ácido gama-Aminobutírico/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Amines); 0 (Cyclohexanecarboxylic Acids); 0 (Muscle Relaxants, Central); 56-12-2 (gamma-Aminobutyric Acid); 6CW7F3G59X (gabapentin); H789N3FKE8 (Baclofen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000002289


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[PMID]:28196104
[Au] Autor:Hosoya R; Uesawa Y; Ishii-Nozawa R; Kagaya H
[Ad] Endereço:Department of Clinical Pharmaceutics, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan.
[Ti] Título:Analysis of factors associated with hiccups based on the Japanese Adverse Drug Event Report database.
[So] Source:PLoS One;12(2):e0172057, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hiccups are occasionally experienced by most individuals. Although hiccups are not life-threatening, they may lead to a decline in quality of life. Previous studies showed that hiccups may occur as an adverse effect of certain medicines during chemotherapy. Furthermore, a male dominance in hiccups has been reported. However, due to the limited number of studies conducted on this phenomenon, debate still surrounds the few factors influencing hiccups. The present study aimed to investigate the influence of medicines and patient characteristics on hiccups using a large-sized adverse drug event report database and, specifically, the Japanese Adverse Drug Event Report (JADER) database. Cases of adverse effects associated with medications were extracted from JADER, and Fisher's exact test was performed to assess the presence or absence of hiccups for each medication. In a multivariate analysis, we conducted a multiple logistic regression analysis using medication and patient characteristic variables exhibiting significance. We also examined the role of dexamethasone in inducing hiccups during chemotherapy. Medicines associated with hiccups included dexamethasone, levofolinate, fluorouracil, oxaliplatin, carboplatin, and irinotecan. Patient characteristics associated with hiccups included a male gender and greater height. The combination of anti-cancer agent and dexamethasone use was noted in more than 95% of patients in the dexamethasone-use group. Hiccups also occurred in patients in the anti-cancer agent-use group who did not use dexamethasone. Most of the medications that induce hiccups are used in chemotherapy. The results of the present study suggest that it is possible to predict a high risk of hiccups using patient characteristics. We confirmed that dexamethasone was the drug that has the strongest influence on the induction of hiccups. However, the influence of anti-cancer agents on the induction of hiccups cannot be denied. We consider the results of the present study to be helpful for the prevention and treatment of hiccups.
[Mh] Termos MeSH primário: Antineoplásicos/efeitos adversos
Bases de Dados Factuais
Dexametasona/efeitos adversos
Soluço/induzido quimicamente
Soluço/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Dexametasona/administração & dosagem
Feminino
Soluço/fisiopatologia
Seres Humanos
Japão/epidemiologia
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172057


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[PMID]:28174382
[Au] Autor:Nakanishi K; Sugiyama K; Abe Y; Endo T; Ohsaki Y
[Ad] Endereço:Dept. of Palliative Care, Asahikawa Medical University Hospital [Currently Dept. of Palliative Care, Asahikawa-Kosei General Hospital].
[Ti] Título:[Persistent Chemotherapy-Induced Hiccups Successfully Treated with Pregabalin].
[So] Source:Gan To Kagaku Ryoho;44(1):63-65, 2017 Jan.
[Is] ISSN:0385-0684
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A 62-year-old male was diagnosed with large cell lung cancer(c-Stage IV)based on pathological examination of an anterior chest tumor. He received chemotherapy with cisplatin, pemetrexed, and bevacizumab. He suffered from persistent hiccups from day 2 of the first course of chemotherapy. He was unsuccessfully treated with chlorpromazine, shakuyakukanzoto, and gabapentin. Therefore, we administered pregabalin to him, and his hiccups subsided immediately. To prevent hiccups, he subsequently took pregabalin along with his chemotherapy regimen, and was able to receive 4 courses of chemotherapy without persistent hiccups. Pregabalin is a possible therapeutic option for treating persistent chemotherapy-induced hiccups.
[Mh] Termos MeSH primário: Adenocarcinoma/tratamento farmacológico
Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos
Cisplatino/efeitos adversos
Soluço/tratamento farmacológico
Neoplasias Pulmonares/tratamento farmacológico
Ácido Oxônico/efeitos adversos
Pregabalina/uso terapêutico
Tegafur/efeitos adversos
[Mh] Termos MeSH secundário: Adenocarcinoma/diagnóstico por imagem
Adenocarcinoma/patologia
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Cisplatino/administração & dosagem
Combinação de Medicamentos
Soluço/induzido quimicamente
Seres Humanos
Neoplasias Pulmonares/diagnóstico por imagem
Neoplasias Pulmonares/patologia
Masculino
Meia-Idade
Ácido Oxônico/administração & dosagem
Tegafur/administração & dosagem
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Drug Combinations); 150863-82-4 (S 1 (combination)); 1548R74NSZ (Tegafur); 55JG375S6M (Pregabalin); 5VT6420TIG (Oxonic Acid); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE


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[PMID]:28041755
[Au] Autor:Gardecki J; Espinosa J; Lucerna A; Bernhardt J
[Ad] Endereço:Department of Emergency Medicine, Rowan University SOM Kennedy University Hospital, Stratford, NJ, USA. Electronic address: gardeckij@gmail.com.
[Ti] Título:Singultus: Avoiding a hiccup in care.
[So] Source:Am J Emerg Med;35(6):938.e1-938.e3, 2017 Jun.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hiccups (singultus) is often a benign, common and self- limited condition. A case of profound electrolyte disturbances presenting with chief complaint of hiccups is presented in which chlorpromazine was not administered and could have been problematic had it been given. For those who present to the ED with chief complaint of hiccups, it is critical to consider a life threatening etiology as the cause of their symptom. This case presents a potential pitfall in the management of singultus.
[Mh] Termos MeSH primário: Soluço/etiologia
Hipopotassemia/diagnóstico
Hiponatremia/diagnóstico
[Mh] Termos MeSH secundário: Clorpromazina/uso terapêutico
Eletrocardiografia
Seres Humanos
Hipopotassemia/tratamento farmacológico
Hiponatremia/tratamento farmacológico
Masculino
Meia-Idade
Potássio/administração & dosagem
Potássio/sangue
Sódio/administração & dosagem
Sódio/sangue
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
9NEZ333N27 (Sodium); RWP5GA015D (Potassium); U42B7VYA4P (Chlorpromazine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170103
[St] Status:MEDLINE


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[PMID]:27885762
[Au] Autor:Kumar S; Minz M; Sinha SK; Vaiphei K; Sharma A; Singh S; Kenwar DB
[Ad] Endereço:Department of Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
[Ti] Título:Esophageal tuberculosis with coexisting opportunistic infections in a renal allograft transplant recipient.
[So] Source:Transpl Infect Dis;19(1), 2017 Feb.
[Is] ISSN:1399-3062
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:We report a renal allograft transplant recipient with esophageal tuberculosis (TB) coinfected with herpes simplex virus (HSV) and Candida. The patient presented with oropharyngeal candidiasis and was started on fluconazole. Upper gastrointestinal endoscopy showed whitish patches with mucosal ulcers in the esophagus. Histopathological examination confirmed TB and HSV infection. The patient recovered after antiviral, antifungal, and anti-tubercular therapy with reduction in immunosuppression. In a TB-endemic zone, TB can coexist with opportunistic infections in an immunocompromised host.
[Mh] Termos MeSH primário: Esofagite/complicações
Herpes Simples/complicações
Imunossupressão/efeitos adversos
Transplante de Rim/efeitos adversos
Infecções Oportunistas/complicações
Tuberculose Gastrointestinal/complicações
[Mh] Termos MeSH secundário: Antifúngicos/uso terapêutico
Antituberculosos/uso terapêutico
Antivirais/uso terapêutico
Candidíase Bucal/tratamento farmacológico
Candidíase Bucal/microbiologia
Transtornos de Deglutição/etiologia
Endoscopia Gastrointestinal
Mucosa Esofágica/patologia
Esofagite/microbiologia
Esofagite/patologia
Esofagite/virologia
Fluconazol/uso terapêutico
Herpes Simples/patologia
Herpes Simples/virologia
Soluço/etiologia
Seres Humanos
Hospedeiro Imunocomprometido
Imuno-Histoquímica
Imunossupressão/métodos
Falência Renal Crônica/cirurgia
Masculino
Meia-Idade
Infecções Oportunistas/microbiologia
Infecções Oportunistas/patologia
Infecções Oportunistas/virologia
Simplexvirus/isolamento & purificação
Transplantados
Transplante Homólogo/efeitos adversos
Tuberculose Gastrointestinal/microbiologia
Tuberculose Gastrointestinal/patologia
Vômito/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Antitubercular Agents); 0 (Antiviral Agents); 8VZV102JFY (Fluconazole)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161126
[St] Status:MEDLINE
[do] DOI:10.1111/tid.12640


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[PMID]:27884550
[Au] Autor:Wolever TM; Chiasson JL; Josse RG; Leiter LA; Maheux P; Rabasa-Lhoret R; Rodger NW; Ryan EA
[Ad] Endereço:Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada; Department of Medicine, St. Michael's Hospital, Toronto, Ontario, Canada. Electronic address: thomas.wolever@utoronto.ca.
[Ti] Título:Effects of Changing the Amount and Source of Dietary Carbohydrates on Symptoms and Dietary Satisfaction Over a 1-Year Period in Subjects with Type 2 Diabetes: Canadian Trial of Carbohydrates in Diabetes (CCD).
[So] Source:Can J Diabetes;41(2):164-176, 2017 Apr.
[Is] ISSN:2352-3840
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To determine the long-term effects of changing the amount or source of dietary carbohydrate on quality of life (QOL), symptoms and dietary satisfaction in people with type 2 diabetes. METHODS: Subjects with diabetes treated by diet alone (n=162) were randomly assigned to high-carbohydrate/high-glycemic-index (HGI) diets; high-carbohydrate/low-glycemic-index (LGI) diets; or lower-carbohydrate/high-monounsaturated-fat (LC) diets for 1 year. We measured QOL at baseline and at study's end, and we measured symptoms and dietary satisfaction quarterly. RESULTS: The HGI, LGI and LC diets contained, respectively, 47±1, 52±1 and 40±1% energy carbohydrate; 30±1, 27±1 and 40±1% fat with GI 64±0.4, 55±0.4 and 59±0.4. Significantly more participants reported increased flatulence on LGI than on LC and HGI diets at 3 months (41%, 19%, 14%; p<0.05), but not at 12 months (29%, 17%, 17%; ns). Abdominal distension was more severe (46% vs. 14%, 19%; p<0.05), and headache less severe (8% vs. 22%, 23%; p<0.05) on LGI than on both other diets. Increased appetite was more severe on LC (33%) than on HGI diets (14%, p<0.05). Joint/limb pains were less severe on LGI (16%) than HGI (28%) diets. LC elicited more severe gloomy thoughts (23%) than LGI (4%; p<0.05) but greater dietary-satisfaction (70%; p<0.05) than LGI (40%) and HGI (48%) diets. For all diets, glycated hemoglobin (A1C) levels increased less in those who gained less weight, had less increased appetite and were more satisfied with the enjoyment obtained from eating. CONCLUSIONS: Each diet elicited increased severity of 1 or more symptoms than the other diets. Although overall dietary satisfaction was greater on the 40% carbohydrate diet than on the 50% carbohydrate diet, the LGI diet was no less satisfying than the HGI diet. Changes in appetite and dietary satisfaction may influence body weight and glycemic control, or vice-versa.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/dietoterapia
Carboidratos da Dieta/farmacologia
[Mh] Termos MeSH secundário: Apetite
Peso Corporal
Dietoterapia/efeitos adversos
Dietoterapia/métodos
Feminino
Flatulência
Índice Glicêmico
Soluço
Seres Humanos
Masculino
Meia-Idade
Qualidade de Vida
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Dietary Carbohydrates)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161126
[St] Status:MEDLINE


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[PMID]:27717586
[Au] Autor:Lee C; Tong LP
[Ad] Endereço:Mater Misericordiae University Hospital, Dublin, Ireland.
[Ti] Título:Termination of Persistent Hiccups by Digital Rectal Massage.
[So] Source:J Emerg Med;52(2):e55, 2017 02.
[Is] ISSN:0736-4679
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Exame Retal Digital/métodos
Soluço/terapia
[Mh] Termos MeSH secundário: Adulto
Tomada de Decisões
Serviço Hospitalar de Emergência/organização & administração
Soluço/fisiopatologia
Seres Humanos
Masculino
Estimulação do Nervo Vago/normas
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161009
[St] Status:MEDLINE


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[PMID]:27286862
[Au] Autor:Yue J; Liu M; Li J; Wang Y; Hung ES; Tong X; Sun Z; Zhang Q; Golianu B
[Ad] Endereço:Department of Acupuncture and Moxibustion, College of Acupuncture and Moxibustion, Heilongjiang University of Chinese Medicine, Harbin, China.
[Ti] Título:Acupuncture for the treatment of hiccups following stroke: a systematic review and meta-analysis.
[So] Source:Acupunct Med;35(1):2-8, 2017 Mar.
[Is] ISSN:1759-9873
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To assess the effectiveness and safety of acupuncture for hiccups following stroke. METHODS: Medline, Embase, CENTRAL, CINAHL, and four Chinese medical databases were searched from their inception to 1 June 2015. The dataset included randomised controlled trials (RCTs) with no language restrictions that compared acupuncture as an adjunct to medical treatment (effectiveness) or acupuncture versus medical treatment (comparative effectiveness) in stroke patients with hiccups. The Cochrane risk of bias tool was used to assess the methodological quality of the trials. RESULTS: Out of 436 potentially relevant studies, five met the inclusion criteria. When acupuncture was compared with other interventions (as sole or adjunctive treatment), meta-analysis revealed a significant difference in favour of cessation of hiccups within a specified time period (CHWST) following intervention when used as an adjunct (risk ratio (RR) 1.59, 95% CI 1.16 to 2.19, I =0%), but not when used alone (RR 1.40, 95% CI 0.79 to 2.47, I =65%, ie, high heterogeneity). No safety information was reported in these studies. CONCLUSIONS: Our systematic review and meta-analysis suggests that acupuncture may be an effective treatment for patients suffering from hiccups following stroke when used as an adjunct to medical treatment. However, due to the limited number of RCTs and poor methodology quality, we cannot reach a definitive conclusion, hence further large, rigorously designed trials are needed.
[Mh] Termos MeSH primário: Terapia por Acupuntura/métodos
Soluço/terapia
Acidente Vascular Cerebral/complicações
[Mh] Termos MeSH secundário: Soluço/etiologia
Seres Humanos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160612
[St] Status:MEDLINE
[do] DOI:10.1136/acupmed-2015-011024



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