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[PMID]:29217814
[Au] Autor:Anitha A; Delhi Kumar CG
[Ad] Endereço:Department of Pediatrics, JIPMER, Puducherry, India. dillikumar14@gmail.com.
[Ti] Título:An Uncommon Cause of Stridor in a Young Infant.
[So] Source:Indian Pediatr;54(11):976, 2017 11 15.
[Is] ISSN:0974-7559
[Cp] País de publicação:India
[La] Idioma:eng
[Mh] Termos MeSH primário: Cistos
Doenças Faríngeas
Sons Respiratórios/etiologia
[Mh] Termos MeSH secundário: Cistos/complicações
Cistos/diagnóstico por imagem
Cistos/patologia
Cistos/cirurgia
Feminino
Seres Humanos
Lactente
Recém-Nascido
Doenças Faríngeas/complicações
Doenças Faríngeas/diagnóstico por imagem
Doenças Faríngeas/patologia
Doenças Faríngeas/cirurgia
Faringe/diagnóstico por imagem
Faringe/patologia
Faringe/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


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[PMID]:29291277
[Au] Autor:Ahmad I; Kirby P; Liming B
[Ad] Endereço:1 Division of Pediatric Otolaryngology, Department of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alto, California, USA.
[Ti] Título:Ectopic Thymic Cyst of the Subglottis: Considerations for Diagnosis and Management.
[So] Source:Ann Otol Rhinol Laryngol;127(3):200-204, 2018 Mar.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To share the diagnostic and management challenges created by an extremely rare airway lesion-the subglottic ectopic thymic cyst. STUDY DESIGN: Case report and literature review. METHODS: We review the presentation, management, and clinical course of an infant who presented with a subglottic mass that was histologically confirmed as a thymic cyst. A brief literature review supplements the case presentation Results: We present the third described case of an ectopic thymic cyst presenting as a subglottic mass. The differential diagnosis of subglottic masses in neonates consists primarily of subglottic hemangioma and mucous retention cysts. Otolaryngologists must be prepared for unexpected findings when dealing with critical airways. We compare the presentation and management of our patient with the 2 previously described cases. We propose an embryologic theory for the origin of these rare lesions. CONCLUSIONS: An ectopic thymic cyst is a rare and unexpected cause of neonatal stridor. Management of pediatric airway lesions must allow for unexpected findings at the time of diagnostic and therapeutic endoscopy. The appropriate management of subglottic thymic cysts is poorly defined, but close surveillance for recurrence is mandatory.
[Mh] Termos MeSH primário: Anormalidades Congênitas/diagnóstico
Doenças da Laringe
Laringoscopia/métodos
Laringe/anormalidades
Cisto Mediastínico
Sons Respiratórios/diagnóstico
[Mh] Termos MeSH secundário: Coristoma
Anormalidades Congênitas/etiologia
Diagnóstico Diferencial
Seres Humanos
Lactente
Doenças da Laringe/diagnóstico
Doenças da Laringe/fisiopatologia
Masculino
Sons Respiratórios/etiologia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180102
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417749609


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[PMID]:29324816
[Au] Autor:Park JH; Cho SJ; White SK; Cox-Ganser JM
[Ad] Endereço:Respiratory Health Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America.
[Ti] Título:Changes in respiratory and non-respiratory symptoms in occupants of a large office building over a period of moisture damage remediation attempts.
[So] Source:PLoS One;13(1):e0191165, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is limited information on the natural history of building occupants' health in relation to attempts to remediate moisture damage. We examined changes in respiratory and non-respiratory symptoms in 1,175 office building occupants over seven years with multiple remediation attempts. During each of four surveys, we categorized participants using a severity score: 0 = asymptomatic; 1 = mild, symptomatic in the last 12 months, but not frequently in the last 4 weeks; 2 = severe, symptomatic at least once weekly in the last 4 weeks. Building-related symptoms were defined as improving away from the building. We used random intercept models adjusted for demographics, smoking, building tenure, and microbial exposures to estimate temporal changes in the odds of building-related symptoms or severity scores independent of the effect of microbial exposures. Trend analyses of combined mild/severe symptoms showed no changes in the odds of respiratory symptoms but significant improvement in non-respiratory symptoms over time. Separate analyses showed increases in the odds of severe respiratory symptoms (odds ratio/year = 1.15‒1.16, p-values<0.05) and severity scores (0.02/year, p-values<0.05) for wheezing and shortness of breath on exertion, due to worsening of participants in the mild symptom group. For non-respiratory symptoms, we found no changes in the odds of severe symptoms but improvement in severity scores (-0.04‒-0.01/year, p-values<0.05) and the odds for mild fever and chills, excessive fatigue, headache, and throat symptoms (0.65-0.79/year, p-values<0.05). Our study suggests that after the onset of respiratory and severe non-respiratory symptoms associated with dampness/mold, remediation efforts might not be effective in improving occupants' health.
[Mh] Termos MeSH primário: Recuperação e Remediação Ambiental
Umidade/efeitos adversos
Umidade/prevenção & controle
Exposição Ocupacional/efeitos adversos
Exposição Ocupacional/prevenção & controle
Saúde do Trabalhador
Doenças Respiratórias/etiologia
Doenças Respiratórias/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Microbiologia do Ar
Poluição do Ar em Ambientes Fechados/efeitos adversos
Poluição do Ar em Ambientes Fechados/prevenção & controle
Asma/epidemiologia
Asma/etiologia
Asma/prevenção & controle
Estudos Transversais
Feminino
Seres Humanos
Modelos Lineares
Masculino
Meia-Idade
Saúde do Trabalhador/tendências
Razão de Chances
Prevalência
Sons Respiratórios/etiologia
Doenças Respiratórias/epidemiologia
Inquéritos e Questionários
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191165


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[PMID]:29365382
[Au] Autor:Chen QP; Zhou RF; Zhang YM; Yang L
[Ad] Endereço:Department of Paediatrics, Taizhou People's Hospital, Taizhou 225300, China.
[Ti] Título:[Efficacy of systemic glucocorticoids combined with inhaled steroid on children with acute laryngitis].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;53(1):53-56, 2018 Jan 07.
[Is] ISSN:1673-0860
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To evaluate the efficacy of systemic glucocorticoid (steroid) combined with high dose inhaled steroid in the treatment of children with acute laryngitis. A total of 78 children with acute laryngitis were randomly divided into study group( =40) and control group( =38) between November 2016 and April 2017. In addition to routine treatment of anti infection and symptomatic treatment, Dexamethasone injection(0.3-0.5 mg/kg, 1-3 d, according to the patient's condition) was provided to each group. In addition to the treatment mentioned above, the study group were assigned to receive 1.0 mg Budesonide suspension for inhalation, oxygen-driven atomizing inhalation, every/30 minutes, 2 times in a row, after that every 12 hours. The improvement of inspiratory dyspnea, hoarseness, barking cough and wheezing of both groups was evaluated at 30 min, 1 h, 2 h, 6 h, 12 h, 24 h and 72 h after treatment.Sigmaplot 11.5 software was used to analyze the data. No significant difference was detected in terms of inspiratory dyspnea, hoarseness, barking cough or stridor score before treatment between the two groups( >0.05). Compared with those before treatment, symptoms of inspiratory dyspnea, hoarseness, barking cough and stridor score of both groups improved markedly at 12 h and 24 h after treatment( <0.05). While there was no significant difference regarding inspiratory dyspnea, hoarseness, barking cough or stridor score at each time point after treatment between the two groups( >0.05). The effective rate was 92.50% and 92.11% in study group and control group, respectively, and no significant difference was noted ( >0.05). Compared with single systemic glucocorticoid, systemic glucocorticoids combined with inhaled steroid possessed similar efficacy in treating acute laryngitis and relieving laryngeal obstruction of children.
[Mh] Termos MeSH primário: Budesonida/uso terapêutico
Dexametasona/uso terapêutico
Glucocorticoides/uso terapêutico
Laringite/tratamento farmacológico
[Mh] Termos MeSH secundário: Doença Aguda
Administração por Inalação
Budesonida/administração & dosagem
Criança
Tosse/tratamento farmacológico
Dexametasona/administração & dosagem
Esquema de Medicação
Dispneia/tratamento farmacológico
Glucocorticoides/administração & dosagem
Rouquidão/tratamento farmacológico
Seres Humanos
Nebulizadores e Vaporizadores
Sons Respiratórios/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Glucocorticoids); 51333-22-3 (Budesonide); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2018.01.012


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[PMID]:29365373
[Au] Autor:Chen C; Tan LT; Xu ZM
[Ad] Endereço:Department of Otorhinolaryngology Head and Neck Surgery, Children's Hospital of Fudan University, 201102 Shanghai, China.
[Ti] Título:[Evaluation and treatment of children's laryngeal clefts].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;53(1):9-15, 2018 Jan 07.
[Is] ISSN:1673-0860
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To provide the experience about the diagnostic process and following management, and to discuss the outcome and predictors in children with laryngeal cleft (LC). A retrospective case study was conducted at an academic children's hospital. Thirty children were diagnosed as laryngeal cleft between January 2016 and April 2017.Airway evaluations were performed using both flexible and rigid endoscopy, and swallowing evaluations were performed using fiberoptic endoscopic examination of swallowing or modified barium swallow. Of 30 cases, 18 were male and 12 were female, ranging in age from birth to 8 years. Two cases were diagnosed as type 0 LC, and they were offered thickened liquid without medication. Throughout follow-up, they remained asymptomatic and showed no respiratory complications. Nineteen children were diagnosed as type â…  LC. Six of them were significantly improved by anti-reflux therapy and feeding instructions. Four children were concomitant with swallowing dysfunction and/or neuromuscular disorders, and they were given a tracheotomy and routine management. Another 4 children were submitted surgical repair when routine treatment failed, and their symptoms were relieved. Five children were concomitant with larygomalacia, and their symptoms were totally ameliorated by supraglottoplasty. Three children were diagnosed as type â…¡ LC. Two of them received surgical repair and clinically improved, and the rest one was treated by anti-reflux therapy and still under follow-up. Three children were diagnosed as type â…¢ LC. One of them was underwent surgical repair and clinically improved. Two children were tracheotomized and treated by anti-reflux therapy. Three cases were diagnosed as type â…£ LC at birth and no one survived. Laryngeal cleft is a rare congenital anomaly manifesting with a variety of symptoms, including swallowing disorder, aspirations, dyspnea, stridor and hoarseness. Diagnosis and treatment of laryngeal clefts is a challenge. The best way to evaluate the LC is FEES by laryngeal endoscopy combined with MLB. Cases with type 0-â…  mostly were significantly improved by anti-reflux therapy and feeding instructions. When routine treatment failed, surgical repair is needed. All the cases with LC type â…¡-â…¢ need surgical repair as soon as possible. For type â…£ cases, early diagnosis, appropriate treatment and management help to reduce mortality and morbidity.
[Mh] Termos MeSH primário: Anormalidades Congênitas/diagnóstico
Anormalidades Congênitas/terapia
Refluxo Gastroesofágico/terapia
Laringe/anormalidades
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Transtornos de Deglutição/etiologia
Feminino
Fluoroscopia
Refluxo Gastroesofágico/etiologia
Rouquidão/etiologia
Seres Humanos
Lactente
Recém-Nascido
Laringoscopia
Masculino
Sons Respiratórios/etiologia
Estudos Retrospectivos
Traqueotomia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2018.01.003


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[PMID]:27779308
[Au] Autor:Flunker JC; Clouser JM; Mannino D; Swanberg J
[Ad] Endereço:Department of Epidemiology, College of Public Health, University of Kentucky, Lexington, Kentucky.
[Ti] Título:Pulmonary function among Latino thoroughbred horse farmworkers.
[So] Source:Am J Ind Med;60(1):35-44, 2017 Jan.
[Is] ISSN:1097-0274
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Latino thoroughbred workers may be at risk for developing abnormal pulmonary function related to occupational exposures. METHODS: Eighty worker participants were recruited via community-based purposive sampling. Questionnaires and spirometry tests were administered by trained lay health promoters. Demographic and occupational factors were assessed for associations with respiratory outcomes via multivariable logistic regression. RESULTS: Twenty-seven percent of participants exhibited abnormal pulmonary function (primarily restrictive), 79% reported any respiratory symptoms, and 94% infrequently used dust masks. Shorter duration of both current horse farm employment (≤5 years) and time living in the United States (≤10 years) increased the odds of abnormal pulmonary function. Shorter time living in the United States increased the odds of upper respiratory symptoms and shorter duration of current horse farm employment increased the odds of lower respiratory symptoms. CONCLUSIONS: Abnormal pulmonary function was high among this vulnerable worker group, suggesting the need for increased dust mask usage and further exposure assessment. Am. J. Ind. Med. 60:35-44, 2017. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Doenças dos Trabalhadores Agrícolas/epidemiologia
Poluição do Ar em Ambientes Fechados/efeitos adversos
Criação de Animais Domésticos
Hispano-Americanos
Exposição por Inalação/efeitos adversos
Doenças Respiratórias/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Doenças dos Trabalhadores Agrícolas/etiologia
Doenças dos Trabalhadores Agrícolas/fisiopatologia
Animais
Tosse/epidemiologia
Tosse/etiologia
Estudos Transversais
Poeira
Dispneia/epidemiologia
Dispneia/etiologia
Feminino
Volume Expiratório Forçado
Inquéritos Epidemiológicos
Cavalos
Seres Humanos
Kentucky/epidemiologia
Pulmão/fisiopatologia
Masculino
Meia-Idade
Projetos Piloto
Sons Respiratórios/etiologia
Doenças Respiratórias/etiologia
Doenças Respiratórias/fisiopatologia
Autorrelato
Espirometria
Capacidade Vital
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dust)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1002/ajim.22667


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[PMID]:29217805
[Au] Autor:Garg N; Gupta N; Shah D; Gupta P
[Ad] Endereço:Departments of Pediatrics and *Radiology, University College of Medical Sciences (University of Delhi) and GTB Hospital, Dilshad Garden, Delhi, India. Correspondence to: Dr Dheeraj Shah, Professor, Department of Pediatrics, University College of Medical Sciences and GTB Hospital, Dilshad Garden, Delhi 110 095, India. shahdheeraj@hotmail.com.
[Ti] Título:Paint in the Pipe: An Unusual Foreign Body.
[So] Source:Indian Pediatr;54(11):963-965, 2017 Nov 15.
[Is] ISSN:0974-7559
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Foreign bodies in the airway can be a diagnostic and therapeutic challenge. CASE CHARACTERISTICS: 30-month-old girl with complaints of noisy and fast breathing following fall over a pile of sand. Sand was suctioned out by direct bronchoscopy. The child improved initially but condition worsened in next four days with marked stridor and wheeze. OBSERVATION: Imaging revealed elongated sharp radiodense opacity in the cervical region, suggestive of foreign body. At repeat bronchoscopy, paint material was removed from the airway, leading to recovery. MESSAGE: Paint material mixed in the sand can adhere to the walls of the airway, and cause persistent symptoms of obstruction.
[Mh] Termos MeSH primário: Corpos Estranhos
Pintura/efeitos adversos
Sons Respiratórios/etiologia
Traqueia
[Mh] Termos MeSH secundário: Broncoscopia
Pré-Escolar
Feminino
Corpos Estranhos/diagnóstico por imagem
Corpos Estranhos/patologia
Corpos Estranhos/fisiopatologia
Seres Humanos
Tomografia Computadorizada por Raios X
Traqueia/diagnóstico por imagem
Traqueia/patologia
Traqueia/fisiopatologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


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[PMID]:29202259
[Au] Autor:Rudas M; Orde S; Nalos M
[Ad] Endereço:Intensive Care Unit, Royal Prince Alfred Hospital, Sydney, NSW, Australia. rudasdoc@yahoo.com.
[Ti] Título:Bedside lung ultrasound in the care of the critically ill.
[So] Source:Crit Care Resusc;19(4):327-336, 2017 Dec.
[Is] ISSN:1441-2772
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To describe the technique and review the utility of bedside lung ultrasound in acute care. SUMMARY: Lung ultrasound is a useful point-of-care investigation in acute care, especially in patients with dyspnoea or haemodynamic instability. Although normal lung parenchyma is not accessible to ultrasound, distinctive artefacts arising from parietal and visceral pleura indirectly imply the presence of normal lung. As aeration of lung tissue reduces with disease process, visual assessment of several pathologic entities by ultrasound becomes possible. Ultrasound can be used for qualitative and quantitative assessment as well as to guide intervention. Compared with supine anteroposterior chest x-rays, lung ultrasound is faster and superior at ruling out pneumothorax and diagnosing lung consolidation, pleural effusions or pulmonary oedema. It is a logical and highly valuable extension of echocardiography and can be incorporated into diagnostic algorithms for assessment of dyspnoea, hypotension, chest pain or trauma. It provides rapid information about potentially reversible pathology in cardiac arrest scenarios. Other advantages include bedside availability, repeatability, provision of dynamic diagnostic information, ease of use and the absence of radiation exposure.
[Mh] Termos MeSH primário: Cuidados Críticos/métodos
Estado Terminal
Pulmão/diagnóstico por imagem
Sistemas Automatizados de Assistência Junto ao Leito
Ultrassonografia
[Mh] Termos MeSH secundário: Algoritmos
Dor no Peito/etiologia
Parada Cardíaca/etiologia
Seres Humanos
Hipotensão/etiologia
Pneumopatias/diagnóstico por imagem
Sons Respiratórios/etiologia
Ressuscitação
Choque/etiologia
Procedimentos Desnecessários
Desmame do Respirador
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


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[PMID]:29045211
[Au] Autor:Palamara K; Nagarur A; Fintelmann FJ; Kohler MJ; Cortazar FB
[Ad] Endereço:From the Departments of Medicine (K.P., A.N., M.J.K., F.B.C.) and Radiology (F.J.F.), Massachusetts General Hospital, and the Departments of Medicine (K.P., A.N., M.J.K., F.B.C.) and Radiology (F.J.F.), Harvard Medical School - both in Boston.
[Ti] Título:Case 32-2017. A 64-Year-Old Man with Dyspnea, Wheezing, Headache, Cough, and Night Sweats.
[So] Source:N Engl J Med;377(16):1569-1578, 2017 10 19.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Anticorpos Anticitoplasma de Neutrófilos/sangue
Granulomatose com Poliangiite/diagnóstico
Peroxidase/imunologia
[Mh] Termos MeSH secundário: Tosse/etiologia
Diagnóstico Diferencial
Dispneia/etiologia
Eosinofilia/etiologia
Fibromialgia/complicações
Granulomatose com Poliangiite/complicações
Granulomatose com Poliangiite/tratamento farmacológico
Cefaleia/etiologia
Seres Humanos
Imunossupressores/uso terapêutico
Pulmão/diagnóstico por imagem
Pulmão/patologia
Masculino
Meia-Idade
Sons Respiratórios/etiologia
Sudorese
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; CLINICAL CONFERENCE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Antineutrophil Cytoplasmic); 0 (Immunosuppressive Agents); EC 1.11.1.7 (Peroxidase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMcpc1703513


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[PMID]:28987219
[Au] Autor:Jartti T; Gern JE
[Ad] Endereço:Department of Paediatrics, Turku University Hospital and University of Turku, Turku, Finland. Electronic address: tuomas.jartti@utu.fi.
[Ti] Título:Role of viral infections in the development and exacerbation of asthma in children.
[So] Source:J Allergy Clin Immunol;140(4):895-906, 2017 Oct.
[Is] ISSN:1097-6825
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Viral infections are closely linked to wheezing illnesses in children of all ages. Respiratory syncytial virus (RSV) is the main causative agent of bronchiolitis, whereas rhinovirus (RV) is most commonly detected in wheezing children thereafter. Severe respiratory illness induced by either of these viruses is associated with subsequent development of asthma, and the risk is greatest for young children who wheeze with RV infections. Whether viral illnesses actually cause asthma is the subject of intense debate. RSV-induced wheezing illnesses during infancy influence respiratory health for years. There is definitive evidence that RSV-induced bronchiolitis can damage the airways to promote airway obstruction and recurrent wheezing. RV likely causes less structural damage and yet is a significant contributor to wheezing illnesses in young children and in the context of asthma. For both viruses, interactions between viral virulence factors, personal risk factors (eg, genetics), and environmental exposures (eg, airway microbiome) promote more severe wheezing illnesses and the risk for progression to asthma. In addition, allergy and asthma are major risk factors for more frequent and severe RV-related illnesses. Treatments that inhibit inflammation have efficacy for RV-induced wheezing, whereas the anti-RSV mAb palivizumab decreases the risk of severe RSV-induced illness and subsequent recurrent wheeze. Developing a greater understanding of personal and environmental factors that promote more severe viral illnesses might lead to new strategies for the prevention of viral wheezing illnesses and perhaps reduce the subsequent risk for asthma.
[Mh] Termos MeSH primário: Asma/imunologia
Microbiota/imunologia
Vírus Sinciciais Respiratórios/imunologia
Rhinovirus/imunologia
Viroses/imunologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/uso terapêutico
Asma/tratamento farmacológico
Bronquiolite
Criança
Progressão da Doença
Seres Humanos
Palivizumab/uso terapêutico
Sons Respiratórios
Vírus Sinciciais Respiratórios/patogenicidade
Rhinovirus/patogenicidade
Risco
Virulência
Viroses/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); DQ448MW7KS (Palivizumab)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171009
[St] Status:MEDLINE



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