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[PMID]:29187728
[Au] Autor:Uz U; Celik O
[Ad] Endereço:Department of Otorhinolaryngology, Bayindir Government Hospital, Bayindir, Izmir, Turkey.
[Ti] Título:Pleomorphic Adenoma of the Posterior Surface of the Soft Palate Causing Sleep Disturbance: A Case Report.
[So] Source:Am J Case Rep;18:1266-1270, 2017 Nov 30.
[Is] ISSN:1941-5923
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Pleomorphic adenoma is the most common benign tumor arising in the salivary gland. The signs and symptoms of pleomorphic adenoma of the minor salivary glands vary, depending on the anatomical site involved. A rare case of pleomorphic adenoma of the posterior surface of the soft palate is reported that caused sleep disturbance, which was resolved with endoscopic surgical treatment. CASE REPORT A 32-year-old woman experienced snoring and mouth-breathing during sleep. Flexible fiberoptic nasopharyngoscopy imaging of the oropharyngeal passage showed obstruction by a tumor the soft palate, which obstructed the oropharyngeal passage. The tumor was excised using endoscopic-assisted transoral surgery and measure 3×2 cm in diameter. Histopathology showed a benign pleomorphic adenoma of the minor salivary gland. Following surgical excision of the tumor, the patient's sleep improved. CONCLUSIONS To our knowledge, this is the first case of a pleomorphic adenoma of the posterior surface of the soft palate, causing sleep disturbance, removed by endoscopic-assisted transoral surgery following pre-operative flexible fiberoptic nasopharyngoscopy imaging of the oropharyngeal passage.
[Mh] Termos MeSH primário: Adenoma Pleomorfo/patologia
Respiração Bucal/etiologia
Palato Mole/patologia
Neoplasias das Glândulas Salivares/patologia
Glândulas Salivares Menores/patologia
Ronco/etiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


  2 / 3741 MEDLINE  
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[PMID]:29028798
[Au] Autor:Siber-Hoogeboom R; Schicht M; Hoogeboom S; Paulsen F; Traxdorf M
[Ad] Endereço:Department of Anatomy II, Friedrich Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
[Ti] Título:Obstructive sleep apnea and rhonchopathy are associated with downregulation of trefoil factor family peptide 3 (TFF3)-Implications of changes in oral mucus composition.
[So] Source:PLoS One;12(10):e0185200, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:STUDY OBJECTIVES: Trefoil factor family (TFF) peptides belong to the family of mucin-associated peptides and are expressed in most mucosal surfaces. TFF peptides carry out functions such as proliferation and migration enhancement, anti-apoptosis, and wound healing. Moreover, TFFs are associated with mucins and interact with them as "linker peptides", thereby influencing mucus viscosity. To test the hypothesis that in rhonchopathy and obstructive sleep apnea (OSA) changes occur in the expression of TFF3 and -2 that could contribute to changes in mucus viscosity, leading to an increase in upper airway resistance during breathing. METHODS: RT-PCR, Western-blot, immunohistochemistry and ELISA were performed to detect and quantify TFF3 and -2 in uvula samples. In addition, 99 saliva samples from patients with mild, moderate or severe OSA, as well as samples from rhonchopathy patients and from healthy volunteers, were analyzed by ELISA. RESULTS: TFF3 was detected in all uvula samples. Immunohistochemistry revealed a subjectively decreasing antibody reactivity of the uvula epithelia with increasing disease severity. ELISA demonstrated significantly higher TFF3 saliva protein concentrations in the healthy control group compared to cases with rhonchopathy and OSA. Predisposing factors of OSA such as BMI or age showed no correlation with TFF3. No significant changes were observed with regard to TFF2. CONCLUSIONS: The results suggest the involvement of TFF3 in the pathogenesis of rhonchopathy and OSA and lead to the hypothesis that reduction of TFF3 production by the epithelium and subepithelial mucous glands of the uvula contribute to an increase in breathing resistance due to a change in mucus organization.
[Mh] Termos MeSH primário: Regulação para Baixo
Mucosa Bucal/metabolismo
Apneia Obstrutiva do Sono/metabolismo
Ronco/metabolismo
Fator Trefoil-3/genética
Fator Trefoil-3/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Estudos de Casos e Controles
Dissacarídeos
Seres Humanos
Ivermectina/análogos & derivados
Masculino
Meia-Idade
Respiração
Apneia Obstrutiva do Sono/genética
Apneia Obstrutiva do Sono/fisiopatologia
Ronco/genética
Ronco/fisiopatologia
Viscosidade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Disaccharides); 0 (Trefoil Factor-3); 70288-86-7 (Ivermectin); 8C43B81H4W (emamectin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171014
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185200


  3 / 3741 MEDLINE  
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[PMID]:28926639
[Au] Autor:Qiu C; Lawrence W; Gelaye B; Stoner L; Frederick IO; Enquobahrie DA; Sorensen TK; Williams MA
[Ad] Endereço:Center for Perinatal Studies, Swedish Medical Center, Seattle, Washington, United States of America.
[Ti] Título:Risk of glucose intolerance and gestational diabetes mellitus in relation to maternal habitual snoring during early pregnancy.
[So] Source:PLoS One;12(9):e0184966, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Obstructive sleep apnea (OSA) or habitual snoring is known to be associated with impaired glucose tolerance and type 2 diabetes among both men and non-pregnant women. We examined the association of habitual snoring during early pregnancy with risk of impaired glucose tolerance (IGT) and gestational diabetes mellitus (GDM). METHODS: A cohort of 1,579 women was interviewed during early pregnancy. We collected information about snoring frequency during early pregnancy. Results from screening and diagnostic tests for IGT and GDM were abstracted from medical records. Multivariate logistic regression models were fitted to estimate odds ratios (OR) and 95% confidence intervals (95% CI) of IGT and GDM associated with snoring in early pregnancy. RESULTS: Overall, women who snored "most or all of the time" had a 2.1-fold increased odds of IGT (OR 2.10; 95% CI 1.31-3.35) and a 2.5-fold increased odds of GDM (OR 2.50; 95% CI 1.34-4.67) as compared with women who never snored. Compared with lean women (pre-pregnancy body mass index (BMI) <25 kg/m2) who did not snore, lean snorers had a 2-fold increased odds of GDM (OR = 1.99, 95% CI: 1.07-3.68). The odds of GDM risk was particularly elevated among overweight women (BMI ≥ 25 kg/m2) who snored (OR = 5.01; 95% CI 2.71-9.26). However, there was no evidence of an interaction between overweight and snoring with GDM risk (p-value = 0.144). CONCLUSIONS: These findings, if confirmed, may have important implications for tailoring prenatal care for overweight pregnant women, and /or those with a history of habitual snoring in early pregnancy.
[Mh] Termos MeSH primário: Diabetes Gestacional/diagnóstico
Intolerância à Glucose/etiologia
Ronco/complicações
[Mh] Termos MeSH secundário: Adulto
Índice de Massa Corporal
Estudos de Coortes
Diabetes Gestacional/etiologia
Feminino
Seres Humanos
Modelos Logísticos
Razão de Chances
Sobrepeso/patologia
Gravidez
Complicações na Gravidez
Cuidado Pré-Natal
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171029
[Lr] Data última revisão:
171029
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184966


  4 / 3741 MEDLINE  
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[PMID]:28831834
[Au] Autor:Hong SN; Yoo J; Song IS; Joo JW; Yoo JH; Kim TH; Lee HM; Lee SH; Lee SH
[Ad] Endereço:1 Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Korea University Ansan Hospital, Ansan, Korea.
[Ti] Título:Does Snoring Time Always Reflect the Severity of Obstructive Sleep Apnea?
[So] Source:Ann Otol Rhinol Laryngol;126(10):693-696, 2017 Oct.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Although it is commonly believed that the degree of snoring reflects the severity of obstructive sleep apnea (OSA), there is often a mismatch between the improvement in OSA and the decrease of snoring time following OSA treatment. The aim of this study was to determine the relationship between OSA severity and snoring time. METHODS: A total of 280 subjects who complained of snoring were divided by apnea-hypopnea index (AHI) into 5 groups. The snoring rate (the amount of sleep time spent snoring divided by the total sleep time) and the clinical data including polysomnographic findings were compared and analyzed. RESULTS: There was no significant correlation between AHI and snoring rate (r = -0.038, P = .524). The snoring rate in the control group was significantly lower than that in the moderate ( P < .001) and severe ( P = .003) groups. The snoring rate in the very severe group was significantly lower than those in the mild ( P < .001), moderate ( P < .001), and severe ( P < .001) groups. However, there was no significant difference between snoring rates in the control group and the very severe group ( P = .832). CONCLUSIONS: The change in snoring rate according to the severity of AHI showed an inverted U-shaped pattern, with a peak in the moderate OSA group.
[Mh] Termos MeSH primário: Índice de Gravidade de Doença
Apneia Obstrutiva do Sono/complicações
Ronco/etiologia
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Meia-Idade
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417727014


  5 / 3741 MEDLINE  
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[PMID]:28774733
[Au] Autor:Farr OM; Rifas-Shiman SL; Oken E; Taveras EM; Mantzoros CS
[Ad] Endereço:Division of Endocrinology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States. Electronic address: ofarr@bidmc.harvard.edu.
[Ti] Título:Current child, but not maternal, snoring is bi-directionally related to adiposity and cardiometabolic risk markers: A cross-sectional and a prospective cohort analysis.
[So] Source:Metabolism;76:70-80, 2017 Nov.
[Is] ISSN:1532-8600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Obstructive sleep apnea (OSA), typically manifested as snoring, is closely associated with obesity. However, the directionality of associations of OSA with cardiometabolic risk markers is unclear, as obesity increases risk for OSA, and OSA results in excess weight gain and its metabolic consequences. Less is known about how obesity and OSA may relate in children and adolescents and whether maternal OSA may influence the development of obesity and cardiometabolic dysfunction in offspring. BASIC PROCEDURES: Among 1078 children from the Project Viva cohort, we examined cross-sectionally and prospectively associations of parent-reported child or maternal snoring with cardiometabolic outcomes, including adiposity, adipokines, and insulin resistance. MAIN FINDINGS: Cross-sectionally, child snoring was related to adiposity and metabolic risk, particularly body mass index (BMI; ß 0.61kg/m , 95% CI 0.33, 0.89; p<0.001), trunk fat mass index (ß 0.23kg/m , CI 0.12, 0.34; p<0.001), high-density lipoprotein cholesterol (ß -1.47mg/dL, CI -2.69, -0.25; p=0.02), and metabolic risk z-score (ß 0.08, CI 0.02, 0.14; p=0.01) after correction for covariates. Prospectively, adiposity (BMI, trunk fat, fat mass, and waist circumference) and cardiometabolic (leptin, HOMA-IR, CRP, and global metabolic risk) measures at mid-childhood (~7y) were associated with child snoring at the early teen visit (~12y) after correction for covariates. Child snoring at ~9y was related to changes in adiposity between mid-childhood and early teen visits. CONCLUSIONS: Child but not maternal snoring, was related to child adiposity and cardiometabolic outcomes. Adiposity and child snoring are associated with each other cross-sectionally and are each predictive of the other among children/adolescents prospectively. These results suggest similar mechanisms in pediatric/adolescent populations as in adults for the development of sleep-disordered breathing and sleep apnea that will need to be confirmed in randomized clinical trials. Importantly, this research points to the need to target both sleep and obesity in order to break this vicious cycle.
[Mh] Termos MeSH primário: Adiposidade/fisiologia
Resistência à Insulina/fisiologia
Obesidade/metabolismo
Apneia Obstrutiva do Sono/metabolismo
Ronco/metabolismo
[Mh] Termos MeSH secundário: Adipocinas/sangue
Adolescente
Índice de Massa Corporal
Doenças Cardiovasculares/etiologia
Doenças Cardiovasculares/metabolismo
Doenças Cardiovasculares/fisiopatologia
Criança
Estudos Transversais
Feminino
Seres Humanos
Masculino
Obesidade/etiologia
Obesidade/fisiopatologia
Estudos Prospectivos
Fatores de Risco
Apneia Obstrutiva do Sono/complicações
Apneia Obstrutiva do Sono/fisiopatologia
Ronco/complicações
Ronco/fisiopatologia
Circunferência da Cintura/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adipokines)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE


  6 / 3741 MEDLINE  
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[PMID]:28738391
[Au] Autor:Li HY
[Ad] Endereço:Department of Otolaryngology, Chang Gung Memorial Hospital, School of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
[Ti] Título:Updated Palate Surgery for Obstructive Sleep Apnea.
[So] Source:Adv Otorhinolaryngol;80:74-80, 2017.
[Is] ISSN:1662-2847
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Initially described in 1981, uvulopalatopharyngoplasty was the first surgical procedure specially designed at the palatal level for snoring and obstructive sleep apnea (OSA). To date, palatal surgery remains the most commonly used surgery for OSA. The advancement of this surgery over the past 30 years has been a process of evolution in concepts, examination, and technique to increase safety and effectiveness in the treatment of OSA. Concept changes have emerged in the disease etiology, purpose of surgery, treatment priorities, staging of operations, integration therapy, and surgical endpoints. Drug-induced sleep examination has become the mainstream for forming a surgical plan. The surgical technique has tended toward the functional expansion and stabilization of airway tissue instead of excision. Here, drug-induced sleep computed tomography is introduced. In addition, palatal surgery is further divided into palatoplasty and pharyngoplasty for individual clinical application.
[Mh] Termos MeSH primário: Palato Mole/cirurgia
Apneia Obstrutiva do Sono/cirurgia
[Mh] Termos MeSH secundário: Seres Humanos
Faringe/cirurgia
Ronco/cirurgia
Úvula/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE
[do] DOI:10.1159/000470869


  7 / 3741 MEDLINE  
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[PMID]:28738377
[Au] Autor:Johnson DM; Soose RJ
[Ti] Título:Updated Nasal Surgery for Obstructive Sleep Apnea.
[So] Source:Adv Otorhinolaryngol;80:66-73, 2017.
[Is] ISSN:1662-2847
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Numerous studies report that difficulty breathing through the nose is associated with reduced sleep quality, increased daytime dysfunction, and increased risk of snoring and obstructive sleep apnea (OSA). Additionally, chronic nasal obstruction often complicates and limits successful medical device therapy for OSA, particularly with continuous positive airway pressure (CPAP). When medical evaluation and management of the nose is inadequate, surgical therapy to lower nasal resistance has been shown to substantially improve sleep and breathing outcome measures. Although nasal surgery in isolation does not have a consistent effect on the apnea-hypopnea index in OSA patients, it does have robust evidence on improving snoring, subjective sleep quality, daytime sleepiness, sleep-related quality of life measures, and other important OSA outcome measures. Furthermore, in OSA patients with sinonasal disease who are struggling with CPAP and other medical devices, sinonasal surgery also has the potential to lower pressure requirements and improve adherence rates. Nasal surgery plays a key adjunctive role in the management of an OSA patient population.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Nasais/métodos
Apneia Obstrutiva do Sono/cirurgia
[Mh] Termos MeSH secundário: Pressão Positiva Contínua nas Vias Aéreas/instrumentação
Seres Humanos
Qualidade de Vida
Ronco/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE
[do] DOI:10.1159/000470868


  8 / 3741 MEDLINE  
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[PMID]:28738368
[Au] Autor:Kotecha B
[Ad] Endereço:Royal National Throat, Nose and Ear Hospital (UCLH), London, UK.
[Ti] Título:Updated Minimally Invasive Surgery for Sleep-Related Breathing Disorders.
[So] Source:Adv Otorhinolaryngol;80:90-98, 2017.
[Is] ISSN:1662-2847
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Sleep-related breathing disorders (SRBD) consist of a variety of clinical entities, ranging from primary snoring to severe obstructive sleep apnoea at the opposite extreme. Although it has no official definition, minimally invasive surgery infers surgery where the procedure is clinically less aggressive and may involve a much smaller incision or none at all. It also implies that such procedures may result in a quicker recovery and reduced morbidity, and that they are often conducted under local anaesthesia as day cases. Minimally invasive surgery in SRBD may be performed on its own or may be conducted in conjunction with other surgical procedures or in association with non-surgical treatment modalities such as oral appliances. Indeed, it may be considered in patients experiencing difficulty tolerating treatment with continuous positive airway pressure. This is with a view to improving the upper airway dimensions and thus reducing the pressure requirement with this type of treatment modality, hence improving its compliance and efficacy. Here we address the role of minimally invasive surgery in SRBD within various anatomical regions of the upper airway, namely the nose, soft palate, and the tongue.
[Mh] Termos MeSH primário: Síndromes da Apneia do Sono/cirurgia
[Mh] Termos MeSH secundário: Pressão Positiva Contínua nas Vias Aéreas
Seres Humanos
Procedimentos Cirúrgicos Minimamente Invasivos/métodos
Procedimentos Cirúrgicos Nasais/métodos
Palato Mole/cirurgia
Síndromes da Apneia do Sono/complicações
Apneia Obstrutiva do Sono/etiologia
Apneia Obstrutiva do Sono/cirurgia
Ronco/etiologia
Ronco/cirurgia
Língua/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE
[do] DOI:10.1159/000470872


  9 / 3741 MEDLINE  
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[PMID]:28738340
[Au] Autor:Ravesloot MJL; Benoist L; van Maanen P; de Vries N
[Ti] Título:Novel Positional Devices for the Treatment of Positional Obstructive Sleep Apnea, and How This Relates to Sleep Surgery.
[So] Source:Adv Otorhinolaryngol;80:28-36, 2017.
[Is] ISSN:1662-2847
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:If untreated, obstructive sleep apnea (OSA) develops as a gradual progressive disease. In the early stage of the disease most patients with OSA are positional. The archetypical patient might progress from simple positional snoring via positional early-stage mild disease to less positional moderate and finally nonpositional severe OSA. At first, the apnea-hypopnea index (AHI) is high only in the supine position, and later is high in all sleeping positions. The phenomenon is reversible. After partial effective treatment, patients with severe OSA can reverse to less severe positional OSA or, in other words, the AHI drops more in the lateral position than in supine position. This has been shown for palatal surgery, multilevel surgery, bimaxillary osteotomies, and bariatric surgery. The absence or presence of positional dependency has a great influence on sleep surgery. First, the results of sleep surgery might be worse in positional patients. Second, the addition of positional therapy to sleep surgery might improve the overall outcome and, as such, enhance the indication of sleep surgery as an alternative to continuous positive airway pressure and mandibular advancement device treatment.
[Mh] Termos MeSH primário: Postura
Apneia Obstrutiva do Sono/etiologia
Apneia Obstrutiva do Sono/cirurgia
[Mh] Termos MeSH secundário: Progressão da Doença
Seres Humanos
Polissonografia
Sono
Ronco/etiologia
Ronco/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE
[do] DOI:10.1159/000470819


  10 / 3741 MEDLINE  
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[PMID]:28738337
[Au] Autor:Yaremchuk K; Garcia-Rodriguez L
[Ti] Título:The History of Sleep Surgery.
[So] Source:Adv Otorhinolaryngol;80:17-21, 2017.
[Is] ISSN:1662-2847
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Snoring and the subsequent diagnosis of obstructive sleep apnea (OSA) was a life-threatening medical condition with no available treatment until the late 20th century. An early description of OSA was provided by Charles Dickens in his 1836 novel Pickwick Papers with the description of a "fat boy" who was thought to be lazy and always falling asleep but likely displayed hypersomnolence from OSA. It was not until 1976 that Ikematsu first described uvulopalatopharyngoplasty (UPPP) as an alternative surgical treatment of "snoring," with a reported cure rate of 81%. The only other surgical procedure for OSA was permanent tracheostomy, but patients suffered from social stigma from the visible stoma with skin flaps and complications such as tracheal granulomas and tracheitis. UPPP was introduced in the USA as an alternative to permanent tracheostomy by Fujita in 1981. Since then, multiple surgical approaches and combinations of approaches have surfaced, with variable success rates.
[Mh] Termos MeSH primário: Apneia Obstrutiva do Sono/história
Ronco/história
[Mh] Termos MeSH secundário: História do Século XX
Seres Humanos
Faringe/cirurgia
Apneia Obstrutiva do Sono/cirurgia
Ronco/cirurgia
Traqueostomia/história
Úvula/cirurgia
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE
[do] DOI:10.1159/000470683



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