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[PMID]:29489694
[Au] Autor:Amraei R; Parsa A; Babaeian M
[Ad] Endereço:Shahid Behshti University of Medical Sciences, Tehran, Iran.
[Ti] Título:Zolpidem-induced sneezing: A case report of positive rechallenge.
[So] Source:Medicine (Baltimore);97(9):e9918, 2018 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Zolpidem, as an imidazopyridine, is a widely prescribed drug in clinical practice for short-term treatment of insomnia. Nevertheless, there have been a number of cases associated with the adverse effects of the stated drug recently. Further to the existing reports of adverse reactions to zolpidem, the current script is going to report a case in which zolpidem has induced acute repetitive sneezes. CONCLUSIONS: A high dose of zolpidem may contribute to interruption to the neurons function involved in the sneezing pathway.
[Mh] Termos MeSH primário: Hipnóticos e Sedativos/efeitos adversos
Piridinas/efeitos adversos
Distúrbios do Início e da Manutenção do Sono/tratamento farmacológico
Espirro/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypnotics and Sedatives); 0 (Pyridines); 7K383OQI23 (zolpidem)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180301
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009918


  2 / 798 MEDLINE  
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[PMID]:28753678
[Au] Autor:Hartley DM; Giannini CM; Wilson S; Frieder O; Margolis PA; Kotagal UR; White DL; Connelly BL; Wheeler DS; Tadesse DG; Macaluso M
[Ad] Endereço:James M. Anderson Center for Health Systems Excellence, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.
[Ti] Título:Coughing, sneezing, and aching online: Twitter and the volume of influenza-like illness in a pediatric hospital.
[So] Source:PLoS One;12(7):e0182008, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study investigates the relation of the incidence of georeferenced tweets related to respiratory illness to the incidence of influenza-like illness (ILI) in the emergency department (ED) and urgent care clinics (UCCs) of a large pediatric hospital. We collected (1) tweets in English originating in our hospital's primary service area between 11/1/2014 and 5/1/2015 and containing one or more specific terms related to respiratory illness and (2) the daily number of patients presenting to our hospital's EDs and UCCs with ILI, as captured by ICD-9 codes. A Support Vector Machine classifier was applied to the set of tweets to remove those unlikely to be related to ILI. Time series of the pooled set of remaining tweets involving any term, of tweets involving individual terms, and of the ICD-9 data were constructed, and temporal cross-correlation between the social media and clinical data was computed. A statistically significant correlation (Spearman ρ = 0.23) between tweets involving the term flu and ED and UCC volume related to ILI 11 days in the future was observed. Tweets involving the terms coughing (Spearman ρ = 0.24) and headache (Spearman ρ = 0.19) individually were also significantly correlated to ILI-related clinical volume four and two days in the future, respectively. In the 2014-2015 cold and flu season, the incidence of local tweets containing the terms flu, coughing, and headache were early indicators of the incidence of ILI-related cases presenting to EDs and UCCs at our children's hospital.
[Mh] Termos MeSH primário: Tosse
Dor
Espirro
Mídias Sociais/estatística & dados numéricos
[Mh] Termos MeSH secundário: Surtos de Doenças/estatística & dados numéricos
Mapeamento Geográfico
Hospitais Pediátricos/estatística & dados numéricos
Seres Humanos
Incidência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170729
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182008


  3 / 798 MEDLINE  
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[PMID]:28518004
[Au] Autor:Sohn JH; Cho KR
[Ad] Endereço:Department of Otorhinolaryngology - Head and Neck Surgery, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Korea.
[Ti] Título:Middle Ear Barotrauma in Student Pilots.
[So] Source:Aerosp Med Hum Perform;88(4):406-412, 2017 Apr 01.
[Is] ISSN:2375-6314
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The present study reports the clinical features of middle ear barotrauma in student pilots in the Republic of Korea Air Force. METHODS: The authors reviewed medical records of student pilots with barotrauma. The grade of barotrauma was assigned using Teed's classification. This study included nasal symptoms, endoscopic findings of the nasal cavity, and clinical course (duration, recurrence). The relationship between middle ear barotrauma and the nasal airway was also evaluated. RESULTS: There were 57 cases in 51 pilots included. There were 49 cases (86.0%) that showed unilateral disease and 4 subjects experienced relapse. Two subjects (3.9%) had chronic rhinosinusitis and four subjects (7.8%) had allergic rhinitis. Ear fullness was reported in all cases, while hearing loss and persistent ear pain were reported in 3 cases (5.3%) and 19 cases (33.3%), respectively. Stuffy nose (26 cases, 45.6%) and rhinorrhea (24 cases, 42.1%) were relatively common. Most cases were Grade 0 (23 cases, 40.3%) or Grade III (27 cases, 47.4%) according to Teed's classification. Septal deviation was observed in 12 cases (21.0%), while turbinate hypertrophy was seen in 53 cases (93.0%) and increased nasal discharge in 33 cases (57.9%). The grade of barotrauma varied significantly according to the severity of turbinate hypertrophy and nasal discharge. The mean duration of disease was 6.8 d. DISCUSSION: Nasal symptoms and endoscopic findings showed some association with the grade and duration of barotrauma. Most cases resolved within a week; however, barotrauma showed persistence or relapse in some cases.Sohn JH, Cho KR. Middle ear barotrauma in student pilots. Aerosp Med Hum Perform. 2017; 88(4):406-412.
[Mh] Termos MeSH primário: Barotrauma/complicações
Barotrauma/diagnóstico
Orelha Média/lesões
Militares
[Mh] Termos MeSH secundário: Adulto
Barotrauma/terapia
Tosse/etiologia
Endoscopia
Feminino
Seres Humanos
Masculino
Cavidade Nasal/patologia
Faringite/etiologia
Pilotos
República da Coreia
Estudos Retrospectivos
Rinite/diagnóstico
Rinite/etiologia
Espirro
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.3357/AMHP.4666.2017


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[PMID]:27893197
[Au] Autor:Bock JM; Schien M; Fischer C; Naehrlich L; Kaeding M; Guntinas-Lichius O; Gerber A; Arnold C; Mainz JG
[Ad] Endereço:Department of Paediatrics, Cystic Fibrosis Centre, Jena University Hospital, Jena, Germany.
[Ti] Título:Importance to question sinonasal symptoms and to perform rhinoscopy and rhinomanometry in cystic fibrosis patients.
[So] Source:Pediatr Pulmonol;52(2):167-174, 2017 Feb.
[Is] ISSN:1099-0496
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Cystic fibrosis (CF) patients almost regularly reveal sinonasal pathology. The purpose of this study was to assess association between objective and subjective measurements of sinonasal involvement comparing nasal airflow obtained by active anterior rhinomanometry (AAR), nasal endoscopic findings, and symptoms assessed with the Sino-Nasal Outcome Test-20 (SNOT-20). METHODS: Nasal cavities were explored by anterior rigid rhinoscopy and findings were compared to inspiratory nasal airflow measured by AAR to quantify nasal patency and subjective health-related quality of life in sinonasal disease obtained with the SNOT-20 questionnaire. Relations to upper and lower airway colonization with Pseudomonas aeruginosa, medical treatment, and sinonasal surgery were analysed. RESULTS: A total of 124 CF patients were enrolled (mean age 19.9 ± 10.4 years, range 4-65 years). A significant association of detection of nasal polyposis (NP) in rhinoscopy was found with increased primary nasal symptoms (PNS) which include "nasal obstruction," "sneezing," "runny nose," "thick nasal discharge," and "reduced sense of smell." At the same time patients with pathologically decreased airflow neither showed elevated SNOT-20 scores nor abnormal rhinoscopic findings. Altogether, rhinomanometric and rhinoscopic findings are not significantly related. CONCLUSIONS: Among SNOT-20 scores the PNS subscore is related to rhinoscopically detected polyposis and sinonasal secretion. Therefore, we recommend including short questions regarding PNS into CF-routine care. At the same time our results show that a high inspiratory airflow is not associated with a good sensation of nasal patency. Altogether, rhinomanometry is not required within routine CF-care, but it can be interesting as an outcome parameter within clinical trials. Pediatr Pulmonol. 2017;52:167-174. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Fibrose Cística/fisiopatologia
Obstrução Nasal/fisiopatologia
Transtornos do Olfato/fisiopatologia
Rinomanometria
Espirro
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Portador Sadio/epidemiologia
Criança
Pré-Escolar
Fibrose Cística/epidemiologia
Endoscopia
Feminino
Seres Humanos
Masculino
Meia-Idade
Cavidade Nasal
Obstrução Nasal/diagnóstico
Obstrução Nasal/epidemiologia
Nariz
Transtornos do Olfato/diagnóstico
Transtornos do Olfato/epidemiologia
Infecções por Pseudomonas/epidemiologia
Pseudomonas aeruginosa
Qualidade de Vida
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161129
[St] Status:MEDLINE
[do] DOI:10.1002/ppul.23613


  5 / 798 MEDLINE  
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[PMID]:27568353
[Au] Autor:Kulas P; Hecker D; Schick B; Bozzato A
[Ad] Endereço:Department of Otorhinolaryngology, Saarland University Medical Center, Kirrberger Strasse, 66421, Homburg/Saar, Germany. philipp.kulas@uks.eu.
[Ti] Título:Investigations on the prevalence of the photo-induced sneezing reflex in the German population, a representative cross-sectional study.
[So] Source:Eur Arch Otorhinolaryngol;274(3):1721-1725, 2017 Mar.
[Is] ISSN:1434-4726
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The sneezing reflex is a common phenomenon in human beings and animals. Until now largely uninvestigated sneezing phenomenon is the photic sneeze reflex, also known as the ACHOO (Autosomal Cholinergic Helio-Ophtalmologic Outburst). This light induced sneezing reflex is triggered by a bright light like the sun but also by artificial light. In former publications the prevalence of this phenomenon in the population is specified up to 35 % and can result in a potential endangerment in numerous everyday situations as driving a car or controlling an airplane. In our present study we interviewed 1042 patients in the Department of Otorhinolaryngology of the Saarland University Hospital using standardized questionnaires to analyse epidemiological data as age, gender and known diseases. Additionally, the questionnaire focused on the occurrence of sneezing events, extend of sneezing, potential triggers, and methods of evasion. In our data analysis, we were able to show a high prevalence of the ACHOO in 57 % of our cohort, suffering from regular light induced sneezing events. Excluding subjects reporting only occasional sneezing events our results were comparable to findings in literature. As expected a familial disposition was observed, additionally tobacco smoking correlated with light induced sneezing events. Analyzing a large cohort, we were able to demonstrate that the prevalence of the ACHOO in the german population may be higher than expected. Taken into account the potential hazard caused by this phenomenon, further investigations should identify the pathophysiologic pathway.
[Mh] Termos MeSH primário: Reflexo
Espirro
[Mh] Termos MeSH secundário: Estudos de Coortes
Estudos Transversais
Feminino
Alemanha
Seres Humanos
Luz
Masculino
Prevalência
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160829
[St] Status:MEDLINE
[do] DOI:10.1007/s00405-016-4256-2


  6 / 798 MEDLINE  
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[PMID]:28269103
[Au] Autor:Monge-Alvarez J; Hoyos-Barcelo C; Lesso P; Escudero J; Dahal K; Casaseca-de-la-Higuera P
[Ti] Título:Effect of importance sampling on robust segmentation of audio-cough events in noisy environments.
[So] Source:Conf Proc IEEE Eng Med Biol Soc;2016:3740-3744, 2016 08.
[Is] ISSN:1557-170X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This paper proposes a new cough detection system based on audio signals acquired from conventional smartphones. The system relies on local Hu moments to characterize cough events and a Λ-NN classifier to distinguish cough events from non-cough ones (speech, laugh, sneeze, etc.) and noisy sounds. To deal with the unbalance between classes, we employ Distinct-Borderline2 Synthetic Minority Oversampling Technique and a bespoke cost matrix. The system additionally features a post-processing module to avoid isolated false negatives and, this way, increases sensitivity. Evaluation has been carried out using a database comprising a variety of cough and non-cough events and different types of background noise. In this study, we specifically focused on noise likely to appear when the user is carrying the smartphone in daily activities. Different Signal to Noise Ratio values were tested ranging between -15 and 0 dB. Our experiments confirm that local Hu moments are suitable not only for characterizing cough events but also for coping with noisy environments. Results show a sensitivity of 94.17% and a specificity of 92.16% at -15 dB. Thus, our system shows potential as a reliable and place-ubiquitous monitoring device that helps patients self-manage their own respiratory diseases and avoids unreported or fabricated symptoms.
[Mh] Termos MeSH primário: Tosse/diagnóstico
Processamento de Sinais Assistido por Computador
Smartphone
[Mh] Termos MeSH secundário: Área Sob a Curva
Bases de Dados Factuais
Seres Humanos
Ruído
Sensibilidade e Especificidade
Razão Sinal-Ruído
Espirro
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1109/EMBC.2016.7591541


  7 / 798 MEDLINE  
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[PMID]:27707425
[Au] Autor:Acar M; Muluk NB; Yigitaslan S; Cengiz BP; Shojaolsadati P; Karimkhani H; Ada S; Berkoz M; Cingi C
[Ad] Endereço:ENT,Yunus Emre State Hospital,Eskisehir,Turkey.
[Ti] Título:Can curcumin modulate allergic rhinitis in rats?
[So] Source:J Laryngol Otol;130(12):1103-1109, 2016 Dec.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: This study aimed to explore the effects of curcumin on experimental allergic rhinitis in rats. METHODS: Twenty-eight male Wistar albino rats were randomly divided into four groups: a control group; a group in which allergic rhinitis was induced and no treatment given; a group in which allergic rhinitis was induced followed by treatment with azelastine hydrochloride on days 21-28; and a group in which allergic rhinitis was induced followed by treatment with curcumin on days 21-28. Allergy symptoms and histopathological features of the nasal mucosa were examined. RESULTS: The sneezing and nasal congestion scores were higher in the azelastine and curcumin treatment groups than in the control group. Histopathological examination showed focal goblet cell metaplasia on the epithelial surface in the azelastine group. In the curcumin group, there was a decrease in goblet cell metaplasia in the epithelium, decreased inflammatory cell infiltration and vascular proliferation in the lamina propria. CONCLUSION: Curcumin is an effective treatment for experimentally induced allergic rhinitis in rats.
[Mh] Termos MeSH primário: Antialérgicos/farmacologia
Anti-Inflamatórios não Esteroides/farmacologia
Curcumina/farmacologia
Células Caliciformes/efeitos dos fármacos
Mucosa Nasal/efeitos dos fármacos
Ftalazinas/farmacologia
Rinite Alérgica/patologia
Espirro/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Intranasal
Animais
Condrócitos/efeitos dos fármacos
Condrócitos/patologia
Cílios/efeitos dos fármacos
Cílios/patologia
Eosinófilos/efeitos dos fármacos
Células Caliciformes/patologia
Hiperemia
Hipertrofia
Masculino
Mastócitos/efeitos dos fármacos
Metaplasia
Mucosa Nasal/patologia
Ovalbumina/efeitos adversos
Distribuição Aleatória
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Allergic Agents); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Phthalazines); 9006-59-1 (Ovalbumin); IT942ZTH98 (Curcumin); ZQI909440X (azelastine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161007
[St] Status:MEDLINE


  8 / 798 MEDLINE  
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[PMID]:27665614
[Au] Autor:Hoehle LP; Phillips KM; Bergmark RW; Caradonna DS; Gray ST; Sedaghat AR
[Ad] Endereço:Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
[Ti] Título:Symptoms of chronic rhinosinusitis differentially impact general health-related quality of life.
[So] Source:Rhinology;54(4):316-322, 2016 Dec 01.
[Is] ISSN:0300-0729
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The degree to which different sinonasal symptoms contribute to the overall quality of life (QOL) detriment in chronic rhinosinusitis (CRS) patients remains unknown. In this study we sought to characterize the effect of different CRS symptoms on the general health-related QOL in patients. METHODOLOGY: We performed a prospective cross-sectional study of 131 adult patients with CRS. Sinonasal symptoms were evaluated using the 22-item Sinonasal Outcomes Test (SNOT-22) and general health-related QOL was evaluated using the EuroQol 5-Dimensional general health-related QOL survey (EQ5D) and visual analog scale (EQ5D-VAS). Health utility values (HUV) were determined using responses to the EQ5D. SNOT-22 scores were broken down into subdomain scores for sleep, nasal, otologic/facial pain and emotional function symptoms. RESULTS: The otologic/facial pain subdomain score consistently had the largest impact on EQ5D-VAS and HUV. After otologic/facial pain, the sleep subdomain score had the second largest effect while the nasal subdomain score had the least impact on general health-related QOL. CONCLUSIONS: Different types of CRS symptoms - most prominently otologic/facial pain and sleep-related symptoms - and their underlying pathophysiologic mechanisms may differentially affect the general health-related QOL detriment associated with CRS. These findings raise the possibility that treatment of the various symptoms associated with CRS may lead to differential improvement in general-health related QOL.
[Mh] Termos MeSH primário: Dor Facial/fisiopatologia
Nível de Saúde
Obstrução Nasal/fisiopatologia
Qualidade de Vida
Rinite/fisiopatologia
Sinusite/fisiopatologia
Transtornos do Sono-Vigília/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Doença Crônica
Estudos Transversais
Dor Facial/etiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Obstrução Nasal/etiologia
Estudos Prospectivos
Rinite/complicações
Rinite/psicologia
Sinusite/complicações
Sinusite/psicologia
Transtornos do Sono-Vigília/etiologia
Espirro
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170221
[Lr] Data última revisão:
170221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160926
[St] Status:MEDLINE
[do] DOI:10.4193/Rhin16.211


  9 / 798 MEDLINE  
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[PMID]:27557321
[Au] Autor:Bourouiba L
[Ad] Endereço:MIT Fluid Dynamics of Disease Transmission Laboratory, Cambridge, MA lbouro@mit.edu.
[Ti] Título:IMAGES IN CLINICAL MEDICINE. A Sneeze.
[So] Source:N Engl J Med;375(8):e15, 2016 Aug 25.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Espirro/fisiologia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160825
[Lr] Data última revisão:
160825
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160825
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMicm1501197


  10 / 798 MEDLINE  
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[PMID]:27480303
[Au] Autor:Chen BW; Qu SH; Li M; Ye LS; Zhang SJ; Qin TJ; Fan H
[Ad] Endereço:Guangxi University of Traditional Chinese Medicine, Nanning 530001, China; Department of Otorhinolaryngology, the People's Hospital of Guangxi Zhuang Autonmous Region, Nanning 530021, China.
[Ti] Título:[A murine model of local allergic rhinitis].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;51(7):533-7, 2016 Jul 07.
[Is] ISSN:1673-0860
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To establish the murine models of local allergic rhinitis (LAR) and allergic rhinitis (AR) by using ovalbumin (OVA), and to investigate the relationship between them. METHODS: Thirty BALB/c mice were divided into 5 groups, (1) the nasally sensitized group (group A1) that was challenged with OVA by a 10 d procedure, (2) the control group of A1 that was challenged with phosphate-buffered saline (PBS), (3) the nasally sensitized group (group A2) that was challenged with OVA by a 25 d procedure, (4)the control group of A2 that was challenged with PBS, (5) the intraperitoneally sensitized group (group B) .The numbers of sneezing after final challenge were counted, and the serum OVA-specific immunoglobulin E (OVA-sIgE), interleukin (IL) -4, IL-13, IL-5 levels in nasal lavage fluid were measured by ELISA. Hematoxylin-eosin staining was performed to evaluate the histological change of nose and lung tissues. Graph Pad Prism 6 software was used to analyze the data. RESULTS: Nasally sensitized group A1 displayed LAR symptoms of sneezing and eosinophilic infiltrating, but without increased OVA-sIgE in serum on day 10 compared with the control group of A1(t=0.697, P>0.05), OVA-sIgE in serum of group A2(2.710±1.406)ng/ml reached to statistical significance and with airway remodeling on day 25 compared with the control group of A2((0.221±0.080)ng/ml, t=4.329, P<0.05). IL-5 and IL-13 in nasal fluid showed a significant increase in the nasally sensitized group A1, compared with the group A2(t values were 2.442, 2.804, P values were less then 0.05). CONCLUSIONS: A short time intranasal instillation with OVA could establish LAR murine model, continuing OVA challenge could increase serum sIgE level and with airway remodeling. LAR mice show a unique characteristic by expressing higher IL-5 and IL-13 in nose than AR mice, but sIgE in serum remains at a normal level.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Ovalbumina
Rinite Alérgica/etiologia
[Mh] Termos MeSH secundário: Administração Intranasal
Animais
Ensaio de Imunoadsorção Enzimática
Eosinófilos
Imunoglobulina E/sangue
Interleucina-13/análise
Interleucina-4/análise
Interleucina-5/análise
Pulmão/patologia
Camundongos
Camundongos Endogâmicos BALB C
Nariz/patologia
Ovalbumina/imunologia
Rinite Alérgica/sangue
Espirro
Cloreto de Sódio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (IL4 protein, human); 0 (Interleukin-13); 0 (Interleukin-5); 207137-56-2 (Interleukin-4); 37341-29-0 (Immunoglobulin E); 451W47IQ8X (Sodium Chloride); 9006-59-1 (Ovalbumin)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170123
[Lr] Data última revisão:
170123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160803
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2016.07.010



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