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  1 / 11 MEDLINE  
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[PMID]:28956468
[Au] Autor:Teaima MH; Abdelhalim SA; El-Nabarawi MA; Attia DA; Helal DA
[Ad] Endereço:a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Cairo University , Cairo , Egypt.
[Ti] Título:Non-ionic surfactant based vesicular drug delivery system for topical delivery of caffeine for treatment of cellulite: design, formulation, characterization, histological anti-cellulite activity, and pharmacokinetic evaluation.
[So] Source:Drug Dev Ind Pharm;44(1):158-171, 2018 Jan.
[Is] ISSN:1520-5762
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cellulite is a common topographical alteration where skin acquires an orange peel or mattress appearance with alterations in adipose tissue and microcirculation. This work aims to develop and evaluate a topical niosomal gel formulae with good permeation to reach the subcutaneous fat layer. Several caffeine niosomal dispersions were prepared and incorporated into gel formulae using Carbopol 940 polymer, chemical penetration enhancers, and iontophoresis, then the prepared gels were applied onto the skin of rats and anticellulite activity of caffeine from the prepared gels compared to that of the commercial product Cellu Destock was evaluated by histological study of the skin and measurement of plasma level of caffeine passing through the skin using liquid chromatography (LC/MS-MS). Results of histology revealed reduction of size and thickness of fatty layer of rat skin in the following order: FVII > FXIV > Cellu Destock > FVII + Iontophoresis > FXIV + Iontophoresis. Pharmacokinetic results of caffeine in plasma revealed that C , T , and AUC decreased in the following order: FXIV > FVII > Cellu Destock . These results conclude that incorporation of caffeine niosomal dispersion into gel matrix with penetration enhancers and iontophoresis resulted in improvement in penetration of caffeine through the skin into the underlying fatty layer in treatment of cellulite.
[Mh] Termos MeSH primário: Resinas Acrílicas/metabolismo
Tecido Adiposo/efeitos dos fármacos
Cafeína/administração & dosagem
Celulite/tratamento farmacológico
Géis/química
Iontoforese/métodos
Lipossomos/metabolismo
Tensoativos/metabolismo
[Mh] Termos MeSH secundário: Resinas Acrílicas/química
Resinas Acrílicas/farmacologia
Administração Cutânea
Animais
Cafeína/química
Química Farmacêutica
Sistemas de Liberação de Medicamentos
Ratos
Tensoativos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylic Resins); 0 (Gels); 0 (Liposomes); 0 (Surface-Active Agents); 3G6A5W338E (Caffeine); 4Q93RCW27E (carbopol 940)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180111
[Lr] Data última revisão:
180111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1080/03639045.2017.1386206


  2 / 11 MEDLINE  
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[PMID]:28661995
[Au] Autor:Kaminer MS; Coleman WP; Weiss RA; Robinson DM; Grossman J
[Ad] Endereço:*Skincare Physicians, Chestnut Hill, Massachusetts; †Coleman Cosmetic and Dermatologic Surgery Center, Metairie, Louisiana; ‡Maryland Laser Skin and Vein Institute, Hunt Valley, Maryland; §Connecticut Dermatology Group, Milford, Connecticut; ‖Ulthera, Inc., Mesa, Arizona.
[Ti] Título:A Multicenter Pivotal Study to Evaluate Tissue Stabilized-Guided Subcision Using the Cellfina Device for the Treatment of Cellulite With 3-Year Follow-Up.
[So] Source:Dermatol Surg;43(10):1240-1248, 2017 Oct.
[Is] ISSN:1524-4725
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cellulite is a common female cosmetic concern for which no single treatment option had been proven effective over the long term. A novel tissue stabilized-guided subsicion system (TS-GS system) has demonstrated significant reduction in the appearance of cellulite after treatment. OBJECTIVE: The objective of this extended follow-up period was to assess the effectiveness of TS-GS out to 3 years after initial treatment. PATIENTS AND METHODS: After completing an open-label, multicenter, pivotal study, 45 subjects were followed for an extended period of up to 3 years after receiving a single treatment using the TS-GS system. Treatment areas were photographed prior to the procedure and at multiple time points post-treatment throughout the 3 years. In this open-label study, subjects served as their own controls. Effectiveness was assessed based on blinded independent physician panel assessments of improvement from baseline using a cellulite severity scale. Subject aesthetic improvement and patient-reported satisfaction were also collected. RESULTS: The results of this trial supported Food and Drug Administration clearance of the device for the long-term reduction in the appearance of cellulite following TS-GS. CONCLUSION: These data further demonstrate the safety and efficacy of this treatment with no reduction in treatment benefits out to 3 years.
[Mh] Termos MeSH primário: Celulite/terapia
Técnicas Cosméticas/instrumentação
[Mh] Termos MeSH secundário: Adulto
Feminino
Seguimentos
Seres Humanos
Meia-Idade
Fatores de Tempo
Resultado do Tratamento
Vácuo
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1097/DSS.0000000000001218


  3 / 11 MEDLINE  
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[PMID]:28095534
[Au] Autor:Christman MP; Belkin D; Geronemus RG; Brauer JA
[Ti] Título:An Anatomical Approach to Evaluating and Treating Cellulite.
[So] Source:J Drugs Dermatol;16(1):58-61, 2017 Jan 01.
[Is] ISSN:1545-9616
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cellulite is the common rippling or dimpling of skin of the thighs and buttocks of women, formed from a confluence of skin laxity, tethering fibrous septa, and fat herniation. We describe an anatomical approach to evaluating the cellulite patient and selecting the best treatment from among available non-invasive, minimally invasive, and invasive therapies. It is crucial to consider the anatomy of the patient and the morphology of cellulite while choosing a treatment. Diffuse rippling represents increased adiposity and/or increased skin laxity which may stand to benefit from lipolytic and skin tightening modalities. Dimpling represents tethering by fibrous septa which may stand to improve from subcision by minimally invasive devices such as Cell na. Patients with both morphologies may be treated with a combination of treatments or Cellulaze. Careful evaluation of the patient can help identify the best therapeutic strategy. J Drugs Dermatol. 2017;16(1):58-61..
[Mh] Termos MeSH primário: Nádegas/patologia
Celulite/diagnóstico
Celulite/terapia
Técnicas Cosméticas
Lasers de Estado Sólido/uso terapêutico
Terapia com Luz de Baixa Intensidade/métodos
Coxa da Perna/patologia
[Mh] Termos MeSH secundário: Tecido Adiposo/patologia
Tecido Adiposo/efeitos da radiação
Nádegas/efeitos da radiação
Feminino
Seres Humanos
Retinoides/administração & dosagem
Coxa da Perna/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Retinoids)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170607
[Lr] Data última revisão:
170607
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE


  4 / 11 MEDLINE  
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[PMID]:27264715
[Au] Autor:Wilczynski S; Koprowski R; Deda A; Janiczek M; Kuleczka N; Blonska-Fajfrowska B
[Ad] Endereço:School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Department of Basic Biomedical Science, Medical University of Silesia in Katowice, Sosnowiec, Poland.
[Ti] Título:Thermographic mapping of the skin surface in biometric evaluation of cellulite treatment effectiveness.
[So] Source:Skin Res Technol;23(1):61-69, 2017 Feb.
[Is] ISSN:1600-0846
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cellulite is one of the worst tolerated aesthetic imperfections. Edema that accompanies cellulite causes disorders of blood flow what may be observed as changes in the skin surface temperature. The aim of this paper was to develop a new method based on the analysis and processing of thermal images of the skin for biometric evaluation of severity of cellulite and monitoring its treatment. METHODS: The observations of the treatment effects were conducted on 10 females (33.4 ± 6.4 years). Thermal images of the volunteers' thighs were captured before starting the therapy (T ). In the following stages: T , T , and T , thermal images were captured 2 weeks after the first, second and third Alidya treatment administration, respectively. Profiled algorithms were developed to determine the mean Grey Level Co-occurrence Matrix (GLCM) contrast in the acquired thermograms. RESULTS: The mean GLCM contrast for the phase T was 70.91, and for the stages T , T , and T : 57.78, 41.80, and 38.53, respectively. CONCLUSION: The use of proposed method (GLCM contrast) enables biometric evaluation of the effectiveness of cellulite treatment. Traditionally used parameters of infrared analysis such as local points of the maximum and minimum temperature or the median temperatures are not useful in thermal, biometric evaluation of anti-cellulite preparations.
[Mh] Termos MeSH primário: Biometria/métodos
Celulite/diagnóstico por imagem
Celulite/tratamento farmacológico
Hipolipemiantes/administração & dosagem
Temperatura Cutânea/efeitos dos fármacos
Termografia/métodos
[Mh] Termos MeSH secundário: Adulto
Monitoramento de Medicamentos/métodos
Feminino
Seres Humanos
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypolipidemic Agents)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160607
[St] Status:MEDLINE
[do] DOI:10.1111/srt.12301


  5 / 11 MEDLINE  
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[PMID]:28099534
[Au] Autor:Roubal PJ; Busuito MJ; Freeman DC; Placzek JD
[Ad] Endereço:Physical Therapy Specialists, PC, Troy, Michigan, USA.
[Ti] Título:A noninvasive mechanical treatment to reduce the visible appearance of cellulite.
[So] Source:Cutis;98(6):393-398, 2016 Dec.
[Is] ISSN:2326-6929
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cellulite is a cosmetic condition of subcutaneous fat herniation through fibrous connective tissue that results in a dimpled appearance of the skin. Occurring in approximately 85% to 90% of all women worldwide, cellulite has been well studied. The result has been the development of a plethora of treatment protocols yielding little to no success. We describe a noninvasive mechanical treatment for women with cellulite, evaluating the safety and effectiveness of a technique that utilizes a unique patented device for the reduction of the visible appearance of cellulite.
[Mh] Termos MeSH primário: Tecido Adiposo/metabolismo
Celulite/terapia
Técnicas Cosméticas
[Mh] Termos MeSH secundário: Adulto
Idoso
Técnicas Cosméticas/efeitos adversos
Técnicas Cosméticas/instrumentação
Desenho de Equipamento
Feminino
Seres Humanos
Meia-Idade
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170608
[Lr] Data última revisão:
170608
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE


  6 / 11 MEDLINE  
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[PMID]:27661433
[Au] Autor:Kaminer MS; Coleman WP; Weiss RA; Grossman J
[Ad] Endereço:Skincare Physicians, Chestnut Hill, Massachusetts Coleman Center for Cosmetic and Dermatologic Surgery, Metairie, Louisiana Maryland Laser Skin and Vein Institute, Hunt Valley, Maryland Ulthera, Inc. Merz Device Innovation Center Mesa, Arizona.
[Ti] Título:Tissue Stabilized-Guided Subcision for the Treatment of Cellulite: A Multicenter Pivotal Study With Two-Year Follow-up.
[So] Source:Dermatol Surg;42(10):1213-6, 2016 Oct.
[Is] ISSN:1524-4725
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Celulite/cirurgia
Técnicas Cosméticas
[Mh] Termos MeSH secundário: Adulto
Feminino
Seguimentos
Seres Humanos
Satisfação do Paciente
Índice de Gravidade de Doença
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160924
[St] Status:MEDLINE
[do] DOI:10.1097/DSS.0000000000000897


  7 / 11 MEDLINE  
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[PMID]:27363766
[Au] Autor:DiBernardo BE; DiBernardo G; Pozner JN
[Ad] Endereço:New Jersey Plastic Surgery, 29 Park Street, Montclair, NJ 07042, USA.
[Ti] Título:Subsurface Laser and Radiofrequency for Face and Body Rejuvenation.
[So] Source:Clin Plast Surg;43(3):527-33, 2016 Jul.
[Is] ISSN:1558-0504
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Minimally invasive devices are a departure from standard laser therapies, because energy is delivered directly below the skin through a 1-mm incision. Lasers can affect such tissues as fat for enhanced disruption, coagulation of small blood vessels, and skin tightening at the right temperatures. Minimally invasive radiofrequency devices can tighten skin but can also improve neck muscle laxity. These devices can achieve results not possible with traditional external devices and, because the skin is not penetrated with energy, a much improved healing profile is seen as well.
[Mh] Termos MeSH primário: Celulite/terapia
Terapia a Laser/métodos
Rejuvenescimento
Envelhecimento da Pele
[Mh] Termos MeSH secundário: Técnicas Cosméticas
Face
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170107
[Lr] Data última revisão:
170107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160702
[St] Status:MEDLINE


  8 / 11 MEDLINE  
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[PMID]:27128239
[Au] Autor:Weiss M; Mahoney AM; Gold M; Lawrence N
[Ad] Endereço:*Maryland Laser, Skin and Vein Institute, Hunt Valley, Maryland; †Gold Skin Care Center, Nashville, Tennessee; ‡Division of Dermatology, Section of Procedural Dermatology, Cooper University Health Care, Marlton, New Jersey.
[Ti] Título:Leg Rejuvenation: A Combination Approach: A Review and Our Experience.
[So] Source:Dermatol Surg;42 Suppl 2:S131-8, 2016 May.
[Is] ISSN:1524-4725
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Patients increasingly seek to enhance the appearance of their legs. Elimination of unwanted leg veins, reduction of epidermal photo-aging changes such as solar lentigines and keratoses, tightening of skin laxity and reduction of adipose tissue are among the most commonly requested goals. Many patients require a combination approach to address their concerns. It is important for dermatologists to be aware of the multitude of procedures that can be performed, often in combination, to rejuvenate the leg. OBJECTIVE: The purpose of this review article was to discuss procedures for improving the appearance of the leg and to share the authors experience, especially in the combination approach to leg rejuvenation. METHODS: A literature search was performed to investigate cosmetic procedures being performed on the leg, with an emphasis on controlled or randomized studies. In addition, the authors contributed their personal experience. RESULTS: Our discussion of the literature review highlights the treatments for leg veins, unwanted fat, cellulite, and photodamage of the legs that are most supported in peer-reviewed publications. CONCLUSION: A synergistic, combination approach to leg rejuvenation works best. This includes the use of injectable agents, energy-based devices, and more invasive surgical procedures.
[Mh] Termos MeSH primário: Terapia a Laser
Rejuvenescimento
Escleroterapia
Envelhecimento da Pele
Varizes/terapia
[Mh] Termos MeSH secundário: Celulite/terapia
Terapia Combinada
Ablação por Ultrassom Focalizado de Alta Intensidade
Seres Humanos
Perna (Membro)
Lipectomia
Ondas de Rádio/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160430
[St] Status:MEDLINE
[do] DOI:10.1097/DSS.0000000000000753


  9 / 11 MEDLINE  
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[PMID]:27128238
[Au] Autor:Coleman KM; Pozner J
[Ad] Endereço:*New Orleans, Louisiana; †Adjunct Clinical Faculty, Department of Plastic Surgery, Cleveland Clinic Florida, Weston, Florida.
[Ti] Título:Combination Therapy for Rejuvenation of the Outer Thigh and Buttock: A Review and Our Experience.
[So] Source:Dermatol Surg;42 Suppl 2:S124-30, 2016 May.
[Is] ISSN:1524-4725
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Combination therapies are becoming more popular as a multifaceted approach to treating common aesthetic conditions. OBJECTIVE: Often, the use of multiple techniques and modalities can lead to improved outcomes; however, there is a lack of current evidence on the use of combination therapies in the literature. METHODS AND MATERIALS: With the recent expansion of minimally and noninvasive options for treatment of the outer thigh and buttock, it is important to understand how these techniques can be used together while avoiding increased risk. RESULTS AND CONCLUSIONS: This review of current available therapeutic options for treatment of the outer thigh and buttock emphasizes current available literature and author experiences.
[Mh] Termos MeSH primário: Nádegas
Técnicas Cosméticas
Rejuvenescimento
Envelhecimento da Pele
Coxa da Perna
[Mh] Termos MeSH secundário: Tecido Adiposo
Celulite/terapia
Terapia Combinada/efeitos adversos
Preenchedores Dérmicos/uso terapêutico
Ablação por Ultrassom Focalizado de Alta Intensidade
Seres Humanos
Próteses e Implantes
Ondas de Rádio/uso terapêutico
Estrias de Distensão/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Dermal Fillers)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160430
[St] Status:MEDLINE
[do] DOI:10.1097/DSS.0000000000000752


  10 / 11 MEDLINE  
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[PMID]:26687236
[Au] Autor:Hsieh TC; Jean SS; Ou TY; Chen FL; Lee WS
[Ad] Endereço:Division of Infectious Disease, Department of Internal Medicine, Wan Fang Medical Center, Taipei Medical University, Taipei, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
[Ti] Título:Starch dust explosion and flame burn injury in a patient complicated with severe cellulites caused by non-O1 Vibrio cholerae.
[So] Source:J Microbiol Immunol Infect;49(4):623-4, 2016 Aug.
[Is] ISSN:1995-9133
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Queimaduras/microbiologia
Celulite/microbiologia
Ciprofloxacino/uso terapêutico
Explosões
Vibrioses/tratamento farmacológico
Vibrio cholerae não O1/efeitos dos fármacos
[Mh] Termos MeSH secundário: Poeira
Seres Humanos
Masculino
Testes de Sensibilidade Microbiana
Amido
Vibrioses/microbiologia
Vibrio cholerae não O1/isolamento & purificação
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Dust); 5E8K9I0O4U (Ciprofloxacin); 9005-25-8 (Starch)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151222
[St] Status:MEDLINE



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