Base de dados : MEDLINE
Pesquisa : C23.888.971 [Categoria DeCS]
Referências encontradas : 1647 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 165 ir para página                         

  1 / 1647 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28931575
[Au] Autor:Nerré AL; Bétrémieux P; Nivot-Adamiak S
[Ad] Endereço:Department of Pediatrics, University of Rennes 1, Rennes, France annelaurenerre@hotmail.fr.
[Ti] Título:Case Report of Clitoral Hypertrophy in 2 Extremely Premature Girls With an Ovarian Cyst.
[So] Source:Pediatrics;140(4), 2017 Oct.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neonatal clitoromegaly is mainly attributed to in utero androgen exposure secondary to congenital adrenal hyperplasia. We report on 2 extremely premature girls with clitoromegaly, increased androgen levels, no salt wasting syndrome, and ovarian cyst. In case 1, the cyst liquid was aspired during ovarian hernia surgery and revealed high androgen levels. After aspiration, serum androgen levels decreased, as did clitoral size. In case 2, an ovarian cyst was seen on pelvic ultrasound. Aspiration was not indicated. The cyst regressed spontaneously on iterative pelvic ultrasounds, and her clitoromegaly decreased. Case 1 demonstrates the ovarian origin of this transient virilization. Cyst formation seems to be linked to the physiologic maturation of the hypothalamic-pituitary-ovarian axis. Thirteen cases of clitoromegaly with hyperandrogenism, without salt wasting syndrome, have been reported in extremely premature infants. In the context of clitoromegaly, we recommend ruling out in utero androgen exposure, adrenal hyperandrogenism, and disorders of sex development. We further recommend affirming hyperandrogenism by androgen assay and confirming ovarian origin with gonadotrophin assays and pelvic ultrasound. Drug therapy abstention and clinical and ultrasound monitoring are recommended because spontaneous regression of clitoral hypertrophy seems to be the most common outcome in the literature, as it was in our 2 observations.
[Mh] Termos MeSH primário: Clitóris/patologia
Hiperandrogenismo/diagnóstico
Doenças do Prematuro/diagnóstico
Cistos Ovarianos/diagnóstico
Virilismo/etiologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Hiperandrogenismo/complicações
Hiperandrogenismo/patologia
Hipertrofia/etiologia
Hipertrofia/patologia
Lactente Extremamente Prematuro
Recém-Nascido
Doenças do Prematuro/patologia
Cistos Ovarianos/complicações
Virilismo/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE


  2 / 1647 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28640966
[Au] Autor:Gurgov S; Bernabé KJ; Stites J; Cunniff CM; Lin-Su K; Felsen D; New MI; Poppas DP
[Ad] Endereço:The Comprehensive Center for Congenital Adrenal Hyperplasia, Institute for Pediatric Urology, Komansky Center for Children's Health, Department of Urology, New York-Presbyterian Hospital/Weill Cornell Medicine, New York, New York.
[Ti] Título:Linking the degree of virilization in females with congenital adrenal hyperplasia to genotype.
[So] Source:Ann N Y Acad Sci;1402(1):56-63, 2017 Aug.
[Is] ISSN:1749-6632
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mutations of CYP21A2 variably decrease 21-hydroxylase activity and result in a spectrum of disease expressions in patients with congenital adrenal hyperplasia (CAH). We examined the association between CYP21A2 mutations and virilization (Prader score) in females with CAH. The study population included 187 CAH females with fully characterized CYP21A2 mutations. One hundred fifty-eight patients were sorted into groups by expected enzyme activity (percent of normal activity) of the less severely affected allele: (A) null, 0%; (B) I2G, 1%; (C) I172N, 2%; and (D) V281L, >2%. We observed an inverse relationship between virilization and residual enzyme activity (P < 0.001). Subjects in group A or B had a significantly higher likelihood (unadjusted odds ratio: 16; P < 0.001) of developing severe virilization compared with those in group C. Surprisingly, 24% of group D patients, whose mutation is usually associated with nonclassical (NC) CAH, had severe virilization. Among subjects with the NC P30L mutation, 66% expressed unexpected virilization. Virilization, usually leading to extensive reconstructive surgery, is highly likely in patients with null or I2G mutations; however, NC mutations (P30L/V281L) may also lead to unexpected virilization. These findings have implications for prenatal counseling and highlight the need for additional investigations into other factors that influence virilization in CAH.
[Mh] Termos MeSH primário: Hiperplasia Suprarrenal Congênita/genética
Virilismo/genética
[Mh] Termos MeSH secundário: Feminino
Genótipo
Seres Humanos
Mutação/genética
Fenótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1111/nyas.13370


  3 / 1647 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28383228
[Au] Autor:Nermoen I; Husebye ES; Myhre AG; Løvås K
[Ad] Endereço:Endokrinologisk avdeling Akershus universitetssykehus og Campus Ahus Institutt for klinisk medisin Universitetet i Oslo.
[Ti] Título:Classic congenital adrenal hyperplasia.
[Ti] Título:Klassisk medfødt binyrebarkhyperplasi..
[So] Source:Tidsskr Nor Laegeforen;137(7):540-543, 2017 Apr.
[Is] ISSN:0807-7096
[Cp] País de publicação:Norway
[La] Idioma:eng; nor
[Ab] Resumo:Congenital adrenal hyperplasia is attributed to inherited enzyme defects in the adrenal cortex. The classical form results in reduced production of cortisol and aldosterone, accompanied by an increase in production of adrenal cortical androgens. This causes virilisation in girls, adrenocortical failure and early puberty in both sexes. This article describes the genetics, clinical picture, diagnostics and treatment.
[Mh] Termos MeSH primário: Hiperplasia Suprarrenal Congênita
[Mh] Termos MeSH secundário: Hiperplasia Suprarrenal Congênita/complicações
Hiperplasia Suprarrenal Congênita/diagnóstico
Hiperplasia Suprarrenal Congênita/tratamento farmacológico
Hiperplasia Suprarrenal Congênita/genética
Feminino
Glucocorticoides/administração & dosagem
Glucocorticoides/uso terapêutico
Seres Humanos
Masculino
Puberdade Precoce/etiologia
Esteroide 21-Hidroxilase/genética
Virilismo/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Glucocorticoids); EC 1.14.14.16 (Steroid 21-Hydroxylase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.4045/tidsskr.16.0376


  4 / 1647 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28228430
[Au] Autor:Durst MA; Wicklow B; Narvey M
[Ad] Endereço:University of Manitoba, Department of Paediatrics and Child Health, Winnipeg, Manitoba, Canada.
[Ti] Título:Atypical case of preterm ovarian hyperstimulation syndrome.
[So] Source:BMJ Case Rep;2017, 2017 Feb 22.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Preterm ovarian hyperstimulation syndrome is a rare syndrome in which preterm infant girls have hypogastric, upper leg and labial swelling accompanied by elevated serum oestradiol levels and ovarian follicular cysts on ultrasound. Our case is an infant born at 23 weeks gestational age who at 30 weeks postconceptional age (PCA) developed elevated 17-hydroxyprogesterone on her newborn screen with associated clitoromegaly and a ventral groove on the inferior aspect of the erectile tissue. An initial pelvic ultrasound at 32 weeks PCA demonstrated a normal appearing uterus, but the ovaries were not visualised. At 39 weeks PCA, follicular ovarian cysts were noted bilaterally (31×26×21 mm on left and 38×25×36 mm on right). Without treatment, oestradiol and testosterone levels began normalising by 42 weeks PCA. After this point, the right ovarian cysts had resolved and the left ovarian cyst continued to diminish in size.
[Mh] Termos MeSH primário: Lactente Extremamente Prematuro
Síndrome de Hiperestimulação Ovariana/sangue
Síndrome de Hiperestimulação Ovariana/complicações
Virilismo/etiologia
[Mh] Termos MeSH secundário: 17-alfa-Hidroxiprogesterona/sangue
Clitóris/patologia
Desidroepiandrosterona/sangue
Estradiol/sangue
Feminino
Seres Humanos
Lactente
Recém-Nascido
Cistos Ovarianos/complicações
Síndrome de Hiperestimulação Ovariana/diagnóstico
Testosterona/sangue
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
3XMK78S47O (Testosterone); 459AG36T1B (Dehydroepiandrosterone); 4TI98Z838E (Estradiol); 68-96-2 (17-alpha-Hydroxyprogesterone)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170310
[Lr] Data última revisão:
170310
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE


  5 / 1647 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28207417
[Au] Autor:Teasdale SL; Morton A
[Ti] Título:Adrenarche unmasks compound heterozygous 3ß-hydroxysteroid dehydrogenase deficiency: c.244G>A (p.Ala82Thr) and the novel 931C>T (p.Gln311*) variant in a non-salt wasting, severely undervirilised 46XY.
[So] Source:J Pediatr Endocrinol Metab;30(3):355-360, 2017 Mar 01.
[Is] ISSN:2191-0251
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:3ß-Hydroxysteroid dehydrogenase type II deficiency (3ßHSD2) congenital adrenal hyperplasia is a rare cause of ambiguous genitalia, resulting in abnormal virilisation in both 46XY and 46XX. We describe a case of 46XY ambiguous genitalia that was misdiagnosed as androgen insensitivity syndrome. The correct diagnosis was made after adrenarche. Genotyping demonstrated compound heterozygosity in two alleles, the previously described c.244G>A (p.Ala82Thr), and a novel 931C>T(p.Gln311*) variant. We suggest that adrenarche unmasked the condition by driving cortisol production to rates that caused the mutant 3bHSD2 enzyme to become rate limiting for cortisol production. This case illustrates how markedly different the effects of this condition may be on androgen production compared with glucocorticoid and mineralocorticoid production. It also demonstrates how current guidelines based on urinary steroids and cortisol sufficiency may not arrive at the correct diagnosis, and underlines the importance of gene testing in the work-up of disorders of sexual differentiation.
[Mh] Termos MeSH primário: 17-Hidroxiesteroide Desidrogenases/genética
Transtornos 46, XY do Desenvolvimento Sexual/genética
Hiperplasia Suprarrenal Congênita/genética
Adrenarca/genética
Transtornos do Desenvolvimento Sexual/genética
Mutação/genética
Virilismo/etiologia
[Mh] Termos MeSH secundário: Transtornos 46, XY do Desenvolvimento Sexual/complicações
Hiperplasia Suprarrenal Congênita/complicações
Biomarcadores/metabolismo
Criança
Transtornos do Desenvolvimento Sexual/metabolismo
Transtornos do Desenvolvimento Sexual/patologia
Feminino
Testes Genéticos
Seres Humanos
Hidrocortisona/metabolismo
Prognóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); EC 1.1.- (17-Hydroxysteroid Dehydrogenases); EC 1.1.1.51 (3 (or 17)-beta-hydroxysteroid dehydrogenase); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE


  6 / 1647 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28190856
[Au] Autor:Kawaguchi Y; Mizuno H; Horikawa M; Kano M; Yamada K; Yamakawa F; Maekawa T; Yamazaki Y; McNamara KM; Sasano H; Hayashi M
[Ad] Endereço:Department of Endocrinology and Diabetes, Japan Community Health care Organization Chukyo Hospital.
[Ti] Título:Virilism and Ectopic Expression of HSD17B5 in Mature Cystic Teratoma.
[So] Source:Tohoku J Exp Med;241(2):125-129, 2017 02.
[Is] ISSN:1349-3329
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Mature cystic teratoma (MCT) is rarely involved in the overproduction of steroid hormones in contrast to sex cord stromal tumors. A 31-year-old woman visited our hospital with hirsutism, hoarseness, and hair loss from the scalp. Serum testosterone and free-testosterone levels were 7.3 ng/ml and 2.3 pg/ml, respectively, which were markedly in excess of the age adjusted female standard levels. Basal blood levels of steroid hormones and serum levels of 17-hydroxyprogesterone at 1 h after intravenous injection of adrenocorticotropic hormone demonstrated that 21-hydroxylase deficiency was not the underlying cause of her virilization. A subsequent chromosomal test with G-banding revealed a karyotype of 46XX. Magnetic resonance imaging revealed a mass in the left ovary, which was subsequently diagnosed as MCT. Detailed pathological analysis of the tumor indicated that it was comprised of skin components, sweat glands, with hair and fat texture, glandular epithelium and fibrous connective tissue, consistent with the characteristic composition of MCT. Immunohistochemical analysis demonstrated marked immunoreactivity of 17beta-hydroxysteroid dehydrogenase (HSD17B5), an enzyme that can convert androstenedione to testosterone. Following surgical removal of the tumor, testosterone and free testosterone levels were markedly decreased (0.3 ng/ml and 0.4 pg/ml, respectively) and other symptoms abated. In conclusion, this is the first report of an ovarian MCT associated with clinical virilization caused by the ectopic production of testosterone possibly because of an overexpression of intratumoral HSD17B5.
[Mh] Termos MeSH primário: 3-Hidroxiesteroide Desidrogenases/genética
Expressão Ectópica do Gene
Hidroxiprostaglandina Desidrogenases/genética
Teratoma/enzimologia
Teratoma/genética
Virilismo/enzimologia
Virilismo/genética
[Mh] Termos MeSH secundário: Adulto
Membro C3 da Família 1 de alfa-Ceto Redutase
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Neoplasias Ovarianas/patologia
Teratoma/complicações
Virilismo/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.1.- (3-Hydroxysteroid Dehydrogenases); EC 1.1.1.- (Hydroxyprostaglandin Dehydrogenases); EC 1.1.1.357 (AKR1C3 protein, human); EC 1.1.1.357 (Aldo-Keto Reductase Family 1 Member C3)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170214
[St] Status:MEDLINE
[do] DOI:10.1620/tjem.241.125


  7 / 1647 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28095038
[Au] Autor:Tong A; Jiang J; Wang F; Li C; Zhang Y; Wu X
[Ti] Título:PURE ANDROGEN-PRODUCING ADRENAL TUMOR: CLINICAL FEATURES AND PATHOGENESIS.
[So] Source:Endocr Pract;23(4):399-407, 2017 Apr 02.
[Is] ISSN:1530-891X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Pure androgen-secreting adrenal tumors (PASATs) are extremely rare, most reports involving only a single case. This study examined 9 cases of PASAT, with an attempt to characterize its clinical features and to explore the pathogenesis. METHODS: Clinical data of 9 patients with PASAT were retrospectively reviewed. Immunostaining was conducted, and the aryl hydrocarbon receptor-interacting protein gene (AIP) was amplified and directly sequenced. RESULTS: The onset age of the patients ranged from 3.5 to 64 years. All 8 female patients had virilization, whereas the 7-year-old male patient presented with sexual precocity. Serum testosterone levels were elevated (4.1 to 52.3 nmol/L). Adrenal masses were detected and removed in all patients and histologically diagnosed as adrenocortical adenoma or carcinoma. Two patients had both PASATs and growth hormone (GH)-secreting pituitary adenomas (GH pituitary adenoma). Immunohistochemistry revealed nuclear immunoreactivity for p53 in 3 of 7 patients and nuclear immunoreactivity for cyclin D1 in 2 of 7 patients. Immunostaining of ß-catenin showed nuclear, cytoplasmic, and membrane immunoreactivity (2 of 7 patients) or merely cytoplasmic immunoreactivity (1 of 7 patients). The adrenocortical carcinoma showed positive staining for both p53 and cyclin D1 and a high Ki-67 index of 60%. Mutations p.Lys177Argfs*19 and p.Asp287Val in the AIP gene were identified in PASATs of the 2 patients with concomitant presence of GH pituitary adenoma. CONCLUSION: Clinical features of PASATs vary with gender and age of the patients. Abnormal p53 and ß-catenin expression might be involved in the tumorigenesis of these tumors. AIP mutations might be responsible for the concomitant presence of PASATs and GH pituitary adenoma. ABBREVIATIONS: ACA = adrenocortical adenoma ACC = adrenocortical carcinoma AIP = aryl hydrocarbon receptor-interacting protein DHEAS = dehydroepiandrosterone sulfate; GH growth hormone PASAT = pure androgen-secreting adrenal tumor.
[Mh] Termos MeSH primário: Neoplasias do Córtex Suprarrenal/secreção
Adenoma Adrenocortical/secreção
Androgênios/secreção
[Mh] Termos MeSH secundário: Adolescente
Neoplasias do Córtex Suprarrenal/genética
Neoplasias do Córtex Suprarrenal/patologia
Adenoma Adrenocortical/genética
Adenoma Adrenocortical/patologia
Adulto
Criança
Pré-Escolar
Análise Mutacional de DNA
Feminino
Seres Humanos
Masculino
Meia-Idade
Puberdade Precoce/genética
Puberdade Precoce/patologia
Estudos Retrospectivos
Virilismo/genética
Virilismo/patologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androgens)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170706
[Lr] Data última revisão:
170706
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE
[do] DOI:10.4158/EP161580.OR


  8 / 1647 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27988272
[Au] Autor:Serrano Mujica LK; Bertolin K; Bridi A; Glanzner WG; Rissi VB; de Camargo FL; Zanella R; Prestes OD; Moresco RN; Antoniazzi AQ; Dias Gonçalves PB; Premaor MO; Comim FV
[Ad] Endereço:Laboratory of Biotechnology and Animal Reproduction - BioRep, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil.
[Ti] Título:The impact of postnatal leuprolide acetate treatment on reproductive characteristics in a rodent model of polycystic ovary syndrome.
[So] Source:Mol Cell Endocrinol;442:125-133, 2017 Feb 15.
[Is] ISSN:1872-8057
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:In this study, a GnRH agonist, leuprolide acetate (LA), was given as a single depot injection before 48 h of life to Wistar female rats allotted to prenatal (E16-18) and postnatal androgenization (day 5 of life) by the use of testosterone propionate, looking for reproductive endpoints. Remarkably, a single injection of LA increased the estrus cycles in the postnatal group (PostN) from 0% to 25% of the estrus cycles in the postnatal LA treated group (PostN L). LA also reduced the serum testosterone levels and cysts and atretic follicles in PostN L in contrast with rats (>100 days) from the PostN group (p = 0.04). Prenatally androgenized rats (PreN) exhibited significant modifications in the hypothalamic genes, such as Gnrh. To the best of our knowledge, this is the first study to show that blockage of the GnRH axis with leuprolide acetate depot prevented the development of typical features (anovulation, cysts, atretic follicles) in a postnatal testosterone propionate rat model of PCOS.
[Mh] Termos MeSH primário: Leuprolida/farmacologia
Síndrome do Ovário Policístico/tratamento farmacológico
Reprodução/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Anovulação/tratamento farmacológico
Anovulação/metabolismo
Ciclo Estral/efeitos dos fármacos
Feminino
Hormônio Liberador de Gonadotropina/metabolismo
Masculino
Folículo Ovariano/metabolismo
Síndrome do Ovário Policístico/metabolismo
Ratos
Ratos Wistar
Testosterona/metabolismo
Virilismo/tratamento farmacológico
Virilismo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
33515-09-2 (Gonadotropin-Releasing Hormone); 3XMK78S47O (Testosterone); EFY6W0M8TG (Leuprolide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161219
[St] Status:MEDLINE


  9 / 1647 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27866458
[Au] Autor:Doraiswamy J; Reddy K; Joshi PA; Gornall R
[Ad] Endereço:a Department of Obstetrcis and Gynaecology , Gloucesershire Hospitals NHS foundation trust , Cheltenham , Gloucestershire , UK.
[Ti] Título:A virilising primary mucinous carcinoid tumour of the ovary in a postmenopausal woman: A diagnostic challenge!
[So] Source:J Obstet Gynaecol;37(1):123-124, 2017 Jan.
[Is] ISSN:1364-6893
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Adenocarcinoma Mucinoso/diagnóstico
Tumor Carcinoide/diagnóstico
Neoplasias Ovarianas/diagnóstico
Virilismo/diagnóstico
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Feminino
Seres Humanos
Meia-Idade
Pós-Menopausa
Virilismo/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161122
[St] Status:MEDLINE
[do] DOI:10.1080/01443615.2016.1225026


  10 / 1647 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27666809
[Au] Autor:Ferrito L; Cobellis G; Giobbi D; Pannunzi CP; Iannilli A; Cherubini V
[Ad] Endereço:Azienda Ospedaliero Universitaria Ospedali Riuniti Ancona, Ancona, Italy. Electronic address: lucia.ferrito@gmail.com.
[Ti] Título:Peripheral Precocious Puberty due to Functioning Adrenocortical Tumor: Description of Two Cases.
[So] Source:J Pediatr Adolesc Gynecol;30(1):e1-e4, 2017 Feb.
[Is] ISSN:1873-4332
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Adrenocortical tumors (ACTs) represent less than 0.2% of all childhood neoplasms. Frequent clinical manifestations are virilization, hypercortisolism, and peripheral precocious puberty (PPP). CASES: We describe two cases in which ACTs were responsible for virilization (case 1) and PPP (case 2) in prepubertal girls. In both cases an ACT diagnosis was made after 5-6 months from the first appearance of clinical signs. Surgery was performed within 1 month of diagnosis, and the benign nature of tumors was histologically confirmed. Despite complete tumor resection, virilizing features persisted. SUMMARY AND CONCLUSIONS: Adrenocortical tumors should be considered early in the assessment of PPP. There is often a significant delay between the onset of symptoms and accurate diagnosis but early treatment is essential to limit the clinical manifestations of androgen overproduction.
[Mh] Termos MeSH primário: Neoplasias do Córtex Suprarrenal/complicações
Puberdade Precoce/etiologia
Virilismo/etiologia
[Mh] Termos MeSH secundário: Pré-Escolar
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160927
[St] Status:MEDLINE



página 1 de 165 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde