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  1 / 21 MEDLINE  
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[PMID]:28578820
[Au] Autor:Lepeytre F; Ghannoum M; Ammann H; Madore F; Troyanov S; Goupil R; Bouchard J
[Ad] Endereço:Division of Nephrology, Department of Medicine, Hôpital du Sacré-CÅ“ur de Montréal, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada.
[Ti] Título:Formulas for Calculated Osmolarity and Osmolal Gap: A Study of Diagnostic Accuracy.
[So] Source:Am J Kidney Dis;70(3):347-356, 2017 Sep.
[Is] ISSN:1523-6838
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The osmolal gap has been used for decades to screen for exposure to toxic alcohols. However, several issues may affect its reliability. We aimed to develop equations to calculate osmolarity with improved performance when used to screen for intoxication to toxic alcohols. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: 7,525 patients undergoing simultaneous measurements of osmolality, sodium, potassium, urea, glucose, and ethanol or undergoing similar measurements performed within 30 minutes of a measurement of toxic alcohol levels at a single tertiary-care center from April 2001 to June 2016. Patients with detectable toxic alcohols were excluded. INDEX TEST: Equations to calculate osmolarity using multiple linear regression. OUTCOMES: The performance of new equations compared with published equations developed to calculate osmolarity, and to diagnose toxic alcohol intoxications more accurately. RESULTS: We obtained 7,525 measurements, including 100 with undetectable toxic alcohols. Among them, 3,875 had undetectable and 3,650 had detectable ethanol levels. In the entire cohort, the best equation to calculate osmolarity was 2.006×Na + 1.228×Urea + 1.387×Glucose + 1.207×Ethanol (values in mmol/L, R =0.96). A simplified equation, 2.0×Na + 1.2×Urea + 1.4×Glucose + 1.2×Ethanol, had a similar R with 95% of osmolal gap values between -10.9 and 13.8. In patients with undetectable ethanol concentrations, the range of 95% of osmolal gap values was narrower than previous published formulas, and in patients with detectable ethanol concentrations, the range was narrower or similar. We performed a subanalysis of 138 cases for which both the toxic alcohol concentration could be measured and the osmolal gap could be calculated. Our simplified equation had superior diagnostic accuracy for toxic alcohol exposure. LIMITATIONS: Single center, no external validation, limited number of cases with detectable toxic alcohols. CONCLUSIONS: In a large cohort, coefficients from regression analyses estimating the contribution of glucose, urea, and ethanol were higher than 1.0. Our simplified formula to precisely calculate osmolarity yielded improved diagnostic accuracy for suspected toxic alcohol exposures than previously published formulas.
[Mh] Termos MeSH primário: Álcoois
Distúrbios Induzidos Quimicamente
[Mh] Termos MeSH secundário: Adulto
Álcoois/química
Álcoois/toxicidade
Glicemia/análise
Canadá
Distúrbios Induzidos Quimicamente/sangue
Distúrbios Induzidos Quimicamente/diagnóstico
Distúrbios Induzidos Quimicamente/etiologia
Precisão da Medição Dimensional
Feminino
Seres Humanos
Modelos Lineares
Masculino
Concentração Osmolar
Valor Preditivo dos Testes
Reprodutibilidade dos Testes
Estudos Retrospectivos
Ureia/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alcohols); 0 (Blood Glucose); 8W8T17847W (Urea)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE


  2 / 21 MEDLINE  
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[PMID]:27528585
[Au] Autor:Onoue S; Seto Y; Sato H; Nishida H; Hirota M; Ashikaga T; Api AM; Basketter D; Tokura Y
[Ad] Endereço:Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address: onoue@u-shizuoka-ken.ac.jp.
[Ti] Título:Chemical photoallergy: photobiochemical mechanisms, classification, and risk assessments.
[So] Source:J Dermatol Sci;85(1):4-11, 2017 Jan.
[Is] ISSN:1873-569X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Chemical photosensitivity can be elicited by exposure of the skin to various pharmaceutical substances, foods, cosmetics and other environmental chemicals, followed by exposure to sunlight. There are at least three types of chemical photosensitivity, i.e., photoirritancy (narrowly defined as phototoxicity), photogenotoxicity and photoallergenicity, and their clinical characteristics and mechanisms are quite different. Concerns about chemical photoallergy is increasing, and various studies have been made to clarify the photobiochemical characteristics of photoallergens and the mechanisms involved. Various methodologies, including in silico prediction models, photochemical assay systems, and in vitro phototoxicity prediction tools, have been developed to predict the photoallergenic potential of chemicals over the past few years. The aim of this manuscript is to review the clinical characteristics, pathogenetic mechanisms and photobiochemical features of photoallergens, with special emphasis on the current status about development of screening systems for predicting photoallergenic potential of chemicals.
[Mh] Termos MeSH primário: Alérgenos/efeitos adversos
Distúrbios Induzidos Quimicamente/etiologia
Dermatite Fotoalérgica/etiologia
Dermatite Fototóxica/etiologia
Medição de Risco
Raios Ultravioleta/efeitos adversos
[Mh] Termos MeSH secundário: Cosméticos/efeitos adversos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/etiologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Allergens); 0 (Cosmetics)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170330
[Lr] Data última revisão:
170330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160817
[St] Status:MEDLINE


  3 / 21 MEDLINE  
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[PMID]:27749260
[Au] Autor:Kadi IE; Dahdouh F
[Ti] Título:Vitamin C pretreatment protects from nickel-induced acute nephrotoxicity in mice.
[So] Source:Arh Hig Rada Toksikol;67(3):210-215, 2016 Sep 01.
[Is] ISSN:1848-6312
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:Nickel is an abundant carcinogenic and nephrotoxic metal whose activity leads to renal impairment. Previous studies have shown a protective effect of simultaneous vitamin C administration on acute and chronic nickel toxicity. However, very little research relating to the effect of vitamin C pretreatment in preventing nickel-induced acute nephrotoxicity is available. Therefore, the present study aimed to determine the efficiency of vitamin C (VC) pretreatment in preventing acute renal toxicity of nickel. Mice were pretreated orally with vitamin C (16.6 mg kg-1 body weight, b.w.) for seven consecutive days, prior to intraperitoneal (i.p.) administration of nickel chloride at different doses (3, 5, and 10 mg Ni kg-1 b.w.) for an exposure period of 24 hours. Thereafter, animals were killed and kidney tissue and blood samples were taken for histological examination and biochemical marker analyses. Vitamin C pretreatment alone did not alter the levels of serum kidney markers (creatinine, urea, and uric acid). However, treatment with Ni alone showed a significant increase in the levels of serum creatinine, urea, and uric acid with marked necrotic epithelial cells and infiltration by inflammatory cells in kidney sections as compared to the control group. Pretreatment with vitamin C and treatment with Ni at all doses tested for 24 hours showed a significant decrease in the levels of serum creatinine, urea, and uric acid, as well as an improvement in histological changes compared to those previously seen in the group treated with Ni alone. It is concluded that vitamin C pretreatment effectively improved renal function and tissue damage caused by nickel.
[Mh] Termos MeSH primário: Lesão Renal Aguda/induzido quimicamente
Antioxidantes/uso terapêutico
Ácido Ascórbico/uso terapêutico
Distúrbios Induzidos Quimicamente/tratamento farmacológico
Níquel/toxicidade
Substâncias Protetoras/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antioxidantes/farmacologia
Ácido Ascórbico/farmacologia
Testes de Função Renal
Masculino
Camundongos
Substâncias Protetoras/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Protective Agents); 696BNE976J (nickel chloride); 7OV03QG267 (Nickel); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161018
[St] Status:MEDLINE


  4 / 21 MEDLINE  
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[PMID]:27687764
[Au] Autor:Sharma S; Sharma KP; Sharma S
[Ad] Endereço:Department of Zoology, University of Rajasthan, Jaipur, 302004, India. shwetdr@gmail.com.
[Ti] Título:Role of Spirulina in mitigating hemato-toxicity in Swiss albino mice exposed to aluminum and aluminum fluoride.
[So] Source:Environ Sci Pollut Res Int;23(24):25280-25287, 2016 Dec.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Aluminum is ingested through foods, water, air, and even drugs. Its intake is potentiated further through foods and tea prepared in aluminum utensils and Al salt added in the drinking water for removal of suspended impurities and also fluoride in the affected areas. The ameliorating role of a blue green alga Spirulina is well documented to various pollutants in the animal models. We, therefore, examined its protective role (230 mg/kg body weight) on the hematology of male Swiss albino mice treated with aluminum (sub-acute = 78.4 mg/kg body weight for 7 days, sub-chronic = 7.8 mg/kg body weight for 90 days) and aluminum fluoride (sub-acute = 103 mg/kg body weight, sub-chronic = 21 mg/kg body weight), along with their recovery after 90 days of sub-chronic exposure. This study revealed significant reduction in the values of RBC (5-18 %), Hb (15-17 %), PCV (8-14 %), and platelets (26-36 %), and increase in WBC (54-124 %) in the treated mice, particularly after sub-acute exposure. Aluminum fluoride was comparatively more toxic than aluminum. Further, Spirulina supplement not only alleviated toxicity of test chemicals in Swiss albino mice but also led to their better recovery after withdrawal.
[Mh] Termos MeSH primário: Compostos de Alumínio/toxicidade
Alumínio/toxicidade
Sangue/efeitos dos fármacos
Distúrbios Induzidos Quimicamente/prevenção & controle
Fluoretos/toxicidade
Spirulina
[Mh] Termos MeSH secundário: Animais
Suplementos Nutricionais
Masculino
Camundongos
Fosfatos
Distribuição Aleatória
Testes de Toxicidade Subaguda
Testes de Toxicidade Subcrônica
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aluminum Compounds); 0 (Phosphates); 15181-43-8 (fluorophosphate); CPD4NFA903 (Aluminum); Q80VPU408O (Fluorides); Z77H3IKW94 (aluminum fluoride)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161001
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-7718-6


  5 / 21 MEDLINE  
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[PMID]:27366016
[Au] Autor:Lee SH; Park S; Lee JW; Hwang IW; Moon HJ; Kim KH; Park SY; Gil HW; Hong SY
[Ad] Endereço:Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea .
[Ti] Título:The Anion Gap is a Predictive Clinical Marker for Death in Patients with Acute Pesticide Intoxication.
[So] Source:J Korean Med Sci;31(7):1150-9, 2016 Jul.
[Is] ISSN:1598-6357
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Pesticide formulation includes solvents (methanol and xylene) and antifreeze (ethylene glycol) whose metabolites are anions such as formic acid, hippuric acid, and oxalate. However, the effect of the anion gap on clinical outcome in acute pesticide intoxication requires clarification. In this prospective study, we compared the anion gap and other parameters between surviving versus deceased patients with acute pesticide intoxication. The following parameters were assessed in 1,058 patients with acute pesticide intoxication: blood chemistry (blood urea nitrogen, creatinine, glucose, lactic acid, liver enzymes, albumin, globulin, and urate), urinalysis (ketone bodies), arterial blood gas analysis, electrolytes (Na(+), K(+), Cl(-) HCO3 (-), Ca(++)), pesticide field of use, class, and ingestion amount, clinical outcome (death rate, length of hospital stay, length of intensive care unit stay, and seriousness of toxic symptoms), and the calculated anion gap. Among the 481 patients with a high anion gap, 52.2% had a blood pH in the physiologic range, 35.8% had metabolic acidosis, and 12.1% had acidemia. Age, anion gap, pesticide field of use, pesticide class, seriousness of symptoms (all P < 0.001), and time lag after ingestion (P = 0.048) were significant risk factors for death in univariate analyses. Among these, age, anion gap, and pesticide class were significant risk factors for death in a multiple logistic regression analysis (P < 0.001). In conclusions, high anion gap is a significant risk factor for death, regardless of the accompanying acid-base balance status in patients with acute pesticide intoxication.
[Mh] Termos MeSH primário: Ânions/química
Biomarcadores/química
Praguicidas/envenenamento
[Mh] Termos MeSH secundário: Equilíbrio Ácido-Base
Acidose/etiologia
Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Ânions/metabolismo
Biomarcadores/metabolismo
Gasometria
Distúrbios Induzidos Quimicamente/mortalidade
Distúrbios Induzidos Quimicamente/patologia
Eletrólitos/análise
Feminino
Seres Humanos
Unidades de Terapia Intensiva
Modelos Logísticos
Masculino
Meia-Idade
Razão de Chances
Estudos Prospectivos
Fatores de Risco
Análise de Sobrevida
Urinálise
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anions); 0 (Biomarkers); 0 (Electrolytes); 0 (Pesticides)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170222
[Lr] Data última revisão:
170222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160702
[St] Status:MEDLINE
[do] DOI:10.3346/jkms.2016.31.7.1150


  6 / 21 MEDLINE  
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[PMID]:27121526
[Au] Autor:Kumar S
[Ad] Endereço:Department of Pharmacology, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly 243 001, Uttar Pradesh, India.
[Ti] Título:Drug-induced diseases (DIDs).
[So] Source:Indian J Med Res;143(2):247, 2016 Feb.
[Is] ISSN:0971-5916
[Cp] País de publicação:India
[La] Idioma:eng
[Mh] Termos MeSH primário: Distúrbios Induzidos Quimicamente
Relação Dose-Resposta a Droga
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160429
[St] Status:MEDLINE
[do] DOI:10.4103/0971-5916.180230


  7 / 21 MEDLINE  
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[PMID]:27104813
[Au] Autor:Tarango Md SM; Liu Md DR
[Ad] Endereço:Pediatric Emergency Medicine Physician, Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA.
[Ti] Título:Pediatric Ingestions: Emergency Department Management.
[So] Source:Pediatr Emerg Med Pract;13(4):1-24; quiz 20, 2016 Apr.
[Is] ISSN:1549-9650
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pediatric ingestions present a common challenge for emergency clinicians. Each year, more than 50,000 children aged less than 5 years present to emergency departments with concern for unintentional medication exposure, and nearly half of all calls to poison centers are for children aged less than 6 years. Ingestion of magnetic objects and button batteries has also become an increasing source of morbidity and mortality. Although fatal pediatric ingestions are rare, the prescription medications most responsible for injury and fatality in children include opioids, sedative/hypnotics, and cardiovascular drugs. Evidence regarding the evaluation and management of common pediatric ingestions is comprised largely of case reports and retrospective studies. This issue provides a review of these studies as well as consensus guidelines addressing the initial resuscitation, diagnosis, and treatment of common pediatric ingestions. Also discussed are current recommendations for decontamination, administration of antidotes for specific toxins, and management of ingested foreign bodies.
[Mh] Termos MeSH primário: Antídotos/farmacologia
Distúrbios Induzidos Quimicamente
Serviços Médicos de Emergência
Corpos Estranhos
Centros de Controle de Intoxicações
[Mh] Termos MeSH secundário: Distúrbios Induzidos Quimicamente/diagnóstico
Distúrbios Induzidos Quimicamente/etiologia
Distúrbios Induzidos Quimicamente/mortalidade
Distúrbios Induzidos Quimicamente/fisiopatologia
Distúrbios Induzidos Quimicamente/terapia
Criança
Pré-Escolar
Gerenciamento Clínico
Serviços Médicos de Emergência/métodos
Serviços Médicos de Emergência/organização & administração
Medicina de Emergência Baseada em Evidências
Corpos Estranhos/diagnóstico
Corpos Estranhos/etiologia
Corpos Estranhos/fisiopatologia
Corpos Estranhos/terapia
Seres Humanos
Avaliação de Resultados (Cuidados de Saúde)
Preparações Farmacêuticas/classificação
Guias de Prática Clínica como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antidotes); 0 (Pharmaceutical Preparations)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160423
[Lr] Data última revisão:
160423
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160423
[St] Status:MEDLINE


  8 / 21 MEDLINE  
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[PMID]:27016191
[Au] Autor:Gaballah HH; Zakaria SS; Elbatsh MM; Tahoon NM
[Ad] Endereço:Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta, Egypt. Electronic address: hanaahibishy@hotmail.com.
[Ti] Título:Modulatory effects of resveratrol on endoplasmic reticulum stress-associated apoptosis and oxido-inflammatory markers in a rat model of rotenone-induced Parkinson's disease.
[So] Source:Chem Biol Interact;251:10-6, 2016 May 05.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:The mechanisms leading to neuronal death in Parkinson's disease (PD) are not fully elucidated; however, mounting evidence implicates endoplasmic reticulum (ER) stress, oxidative damage, and inflammatory changes are the crucial factors in its pathogenesis. This study was undertaken to investigate the modulatory effects of resveratrol on ER stress-mediated apoptosis, inflammatory and oxidative stress markers in a rat model of rotenone-induced PD. mRNA expression levels of ER stress markers; C/EBP homologous protein (CHOP) and glucose-regulated protein 78 (GRP78), were estimated in the rat brain using quantitative real-time PCR. Caspase-3 activity, IL-1ß levels and Nuclear Factor Erythroid 2-related factor (Nrf2) DNA-binding activity were estimated by ELISA, while glutathione peroxidase and Xanthine oxidase activities, as well as protein carbonyl contents in the rat brain were evaluated spectrophotometrically. Our data revealed that Resveratrol ameliorated rotenone-induced ER stress by downregulating CHOP and GRP78 genes expression and hampered caspase-3 activity in the brain of rotenone exposed rats. It also restored redox balance as evident by suppressing Xanthine oxidase activity and protein carbonyls formation; in addition to preservation of intracellular antioxidants status via activating glutathione peroxidase and Nrf2 signaling pathway. In conclusion; our study launched promising avenues for the potential use of resveratrol as a neuroprotective therapeutic agent in Parkinson's disease.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Distúrbios Induzidos Quimicamente
Estresse do Retículo Endoplasmático/efeitos dos fármacos
Doença de Parkinson
Rotenona
Estilbenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Biomarcadores/sangue
Caspase 3/metabolismo
Modelos Animais de Doenças
Estresse do Retículo Endoplasmático/genética
Ativação Enzimática/efeitos dos fármacos
Regulação da Expressão Gênica/efeitos dos fármacos
Proteínas de Choque Térmico HSP70/genética
Inflamação/induzido quimicamente
Masculino
Proteínas de Membrana/genética
Ratos
Ratos Wistar
Reação em Cadeia da Polimerase em Tempo Real
Fator de Transcrição CHOP/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (HSP70 Heat-Shock Proteins); 0 (Membrane Proteins); 0 (Stilbenes); 0 (glucose-regulated proteins); 03L9OT429T (Rotenone); 147336-12-7 (Transcription Factor CHOP); EC 3.4.22.- (Caspase 3); Q369O8926L (resveratrol)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160419
[Lr] Data última revisão:
160419
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160327
[St] Status:MEDLINE


  9 / 21 MEDLINE  
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[PMID]:26647982
[Au] Autor:Kabata PM; Waldman W; Sein Anand J
[Ad] Endereço:Pomorskie Centrum Toksykologii / Pomeranian Center of Toxicology, Gdansk, Poland. p.kabata@pctox.pl.
[Ti] Título:[Toxicological consultation data management system based on experience of Pomeranian Center of Toxicology].
[Ti] Título:System zarzadzania informacja toksykologiczna na podstawie doswiadczen Pomorskiego Centrum Toksykologii..
[So] Source:Med Pr;66(5):635-44, 2015.
[Is] ISSN:0465-5893
[Cp] País de publicação:Poland
[La] Idioma:pol
[Ab] Resumo:BACKGROUND: In this paper the structure of poisonings is described, based on the material collected from tele-toxicology consults by the Pomeranian Center of Toxicology in Gdansk and harvested from its Electronic Poison Information Management System. In addition, we analyzed conclusions drawn from a 27-month operation of the system. MATERIAL AND METHODS: Data were harvested from the Electronic Poison Information Management System developed in 2012 and used by the Pomeranian Center of Toxicology since then. The research was based on 2550 tele-toxicology consults between January 1 and December 31, 2014. Subsequently the data were electronically cleaned and presented using R programming language. RESULTS: The Pomeranian voivodeship was the prevalent localisation of calls (N = 1879; 73.7%). Most of the calls came from emergency rooms (N = 1495; 58.63%). In the case of 1396 (54.7%) patients the time-lag between intoxication and the consult was less than 6 h. There were no differences in the age distribution between genders. Mean age was 26.3 years. Young people predominated among intoxicated individuals. The majority of intoxications were incidental (N = 888; 34.8%) or suicidal (N = 814; 31.9%) and the most of them took place in the patient's home. CONCLUSIONS: Information about Poison Control Center consultations access should be better spread among medical service providers. The extent of poison information collected by Polish Poison Control Centers should be limited and unified. This should contribute to the increased percentage of properly documented consultations. Additional duties stemming from the need of digital archiving of consults provided, require the involvement of additional staff, leading to the increased operation costs incurred by Poison Control Centers.
[Mh] Termos MeSH primário: Centros de Controle de Intoxicações/organização & administração
Centros de Controle de Intoxicações/estatística & dados numéricos
Encaminhamento e Consulta/estatística & dados numéricos
Toxicologia/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Distúrbios Induzidos Quimicamente/epidemiologia
Criança
Feminino
Troca de Informação em Saúde
Seres Humanos
Internet
Masculino
Meia-Idade
Polônia/epidemiologia
Fatores Sexuais
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mês de entrada:1602
[Cu] Atualização por classe:151209
[Lr] Data última revisão:
151209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151210
[St] Status:MEDLINE


  10 / 21 MEDLINE  
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[PMID]:26276946
[Au] Autor:Carroll EE; Johnson MS
[Ad] Endereço:Army Institute of Public Health, Aberdeen Proving Ground, MD.
[Ti] Título:Toxicity Testing in the 21st Century: Refining the Army's Toolbox.
[So] Source:US Army Med Dep J;:60-3, 2015 Jul-Sep.
[Is] ISSN:1524-0436
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Distúrbios Induzidos Quimicamente/diagnóstico
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/diagnóstico
Testes de Toxicidade
[Mh] Termos MeSH secundário: Distúrbios Induzidos Quimicamente/prevenção & controle
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/prevenção & controle
Seres Humanos
Medicina Militar/métodos
Melhoria de Qualidade
Testes de Toxicidade/métodos
Testes de Toxicidade/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1511
[Cu] Atualização por classe:150816
[Lr] Data última revisão:
150816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150816
[St] Status:MEDLINE



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