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[PMID]:29429505
[Au] Autor:Seneschal J
[Ad] Endereço:Centre de référence des maladies rares de la peau, hôpital Saint-André, CHU de Bordeaux, BMGIC, INSERM U1035, équipe immunodermatologie ATIP-AVENIR, France. Electronic address: julien.seneschal@chu-bordeaux.fr.
[Ti] Título:[What's new in dermatological research?]
[Ti] Título:Quoi de neuf en recherche dermatologique ?.
[So] Source:Ann Dermatol Venereol;143 Suppl 3:S19-S22, 2016 Dec.
[Is] ISSN:0151-9638
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Many research studies dedicated to skin have been published in 2016 in high impact factor journals. This article summarises a selection of research works published between December 2015 and September 2016. New insights into the understanding of the mechanisms involved in psoriasis and atopic dermatitis can lead to better management of these chronic inflammatory disorders. Moreover, a better understanding of the relation between the host and the environment could lead to new therapeutic strategies. Finally, new devices first dedicated to skin inflammatory diseases have been developed with success that could be extended to other chronic inflammatory disorders.
[Mh] Termos MeSH primário: Dermatopatias
[Mh] Termos MeSH secundário: Animais
Reabsorção Óssea/fisiopatologia
Dermatologia
Engenharia Genética
Terapia Genética
Seres Humanos
Inflamação/fisiopatologia
Mordeduras e Picadas de Insetos/imunologia
Janus Quinase 3/antagonistas & inibidores
Microbiota
Inibidores de Proteínas Quinases/uso terapêutico
Dermatopatias/diagnóstico
Dermatopatias/imunologia
Dermatopatias/terapia
Venenos de Aranha/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Protein Kinase Inhibitors); 0 (Spider Venoms); EC 2.7.10.2 (Janus Kinase 3)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


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[PMID]:29023574
[Au] Autor:Kammoun-Rebai W; Bahi-Jaber N; Naouar I; Toumi A; Ben Salah A; Louzir H; Meddeb-Garnaoui A
[Ad] Endereço:Laboratory of Medical Parasitology, Biotechnologies and Biomolecules, Institut Pasteur de Tunis, Tunis, Tunisia.
[Ti] Título:Human cellular and humoral immune responses to Phlebotomus papatasi salivary gland antigens in endemic areas differing in prevalence of Leishmania major infection.
[So] Source:PLoS Negl Trop Dis;11(10):e0005905, 2017 Oct.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Sand fly saliva compounds are able to elicit specific immune responses that have a significant role in Leishmania parasite establishment and disease outcome. Characterizing anti-saliva immune responses in individuals living in well defined leishmaniasis endemic areas would provide valuable insights regarding their effect on parasite transmission and establishment in humans. METHODOLOGY/PRINCIPAL FINDINGS: We explored the cellular and humoral immune responses to Phlebotomus (P.) papatasi salivary gland extracts (SGE) in individuals living in cutaneous leishmaniasis (CL) old or emerging foci (OF, EF). OF was characterized by a higher infection prevalence as assessed by higher proportions of leishmanin skin test (LST) positive individuals compared to EF. Subjects were further subdivided into healed, asymptomatic or naïve groups. We showed anti-SGE proliferation in less than 30% of the individuals, regardless of the immune status, in both foci. IFN-γ production was higher in OF and only observed in immune individuals from OF and naïve subjects from EF. Although IL-10 was not detected, addition of anti-human IL-10 antibodies revealed an increase in proliferation and IFN-γ production only in individuals from OF. The percentage of seropositive individuals was similar in immune and naïves groups but was significantly higher in OF. No correlation was observed between anti-saliva immune responses and LST response. High anti-SGE-IgG responses were associated with an increased risk of developing ZCL. No differences were observed for anti-SGE humoral or cellular responses among naïve individuals who converted or not their LST response or developed or not ZCL after the transmission season. CONCLUSIONS/SIGNIFICANCE: These data suggest that individuals living in an old focus characterized by a frequent exposure to sand fly bites and a high prevalence of infection, develop higher anti-saliva IgG responses and IFN-γ levels and a skew towards a Th2-type cellular response, probably in favor of parasite establishment, compared to those living in an emerging focus.
[Mh] Termos MeSH primário: Antígenos/imunologia
Imunidade Celular
Imunidade Humoral
Proteínas de Insetos/imunologia
Leishmaniose Cutânea/epidemiologia
Phlebotomus/imunologia
Proteínas e Peptídeos Salivares/imunologia
[Mh] Termos MeSH secundário: Adolescente
Animais
Infecções Assintomáticas/epidemiologia
Criança
Doenças Endêmicas
Feminino
Seres Humanos
Imunoglobulina G/sangue
Mordeduras e Picadas de Insetos
Interferon gama/imunologia
Interleucina-10/biossíntese
Interleucina-10/imunologia
Leishmania major/imunologia
Leishmaniose Cutânea/imunologia
Leishmaniose Cutânea/parasitologia
Leishmaniose Cutânea/transmissão
Masculino
Prevalência
Saliva/química
Saliva/imunologia
Proteínas e Peptídeos Salivares/química
Células Th2
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens); 0 (IL10 protein, human); 0 (Immunoglobulin G); 0 (Insect Proteins); 0 (Salivary Proteins and Peptides); 130068-27-8 (Interleukin-10); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171105
[Lr] Data última revisão:
171105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005905


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[PMID]:28991904
[Au] Autor:Kamiya T; Greischar MA; Mideo N
[Ad] Endereço:Department of Ecology & Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada.
[Ti] Título:Epidemiological consequences of immune sensitisation by pre-exposure to vector saliva.
[So] Source:PLoS Negl Trop Dis;11(10):e0005956, 2017 Oct.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Blood-feeding arthropods-like mosquitoes, sand flies, and ticks-transmit many diseases that impose serious public health and economic burdens. When a blood-feeding arthropod bites a mammal, it injects saliva containing immunogenic compounds that facilitate feeding. Evidence from Leishmania, Plasmodium and arboviral infections suggests that the immune responses elicited by pre-exposure to arthropod saliva can alter disease progression if the host later becomes infected. Such pre-sensitisation of host immunity has been reported to both exacerbate and limit infection symptoms, depending on the system in question, with potential implications for recovery. To explore if and how immune pre-sensitisation alters the effects of vector control, we develop a general model of vector-borne disease. We show that the abundance of pre-sensitised infected hosts should increase when control efforts moderately increase vector mortality rates. If immune pre-sensitisation leads to more rapid clearance of infection, increasing vector mortality rates may achieve greater than expected disease control. However, when immune pre-sensitisation prolongs the duration of infection, e.g., through mildly symptomatic cases for which treatment is unlikely to be sought, vector control can actually increase the total number of infected hosts. The rising infections may go unnoticed unless active surveillance methods are used to detect such sub-clinical individuals, who could provide long-lasting reservoirs for transmission and suffer long-term health consequences of those sub-clinical infections. Sensitivity analysis suggests that these negative consequences could be mitigated through integrated vector management. While the effect of saliva pre-exposure on acute symptoms is well-studied for leishmaniasis, the immunological and clinical consequences are largely uncharted for other vector-parasite-host combinations. We find a large range of plausible epidemiological outcomes, positive and negative for public health, underscoring the need to quantify how immune pre-sensitisation modulates recovery and transmission rates in vector-borne diseases.
[Mh] Termos MeSH primário: Vetores Artrópodes/imunologia
Modelos Biológicos
Saliva/imunologia
[Mh] Termos MeSH secundário: Animais
Culicidae/imunologia
Interações Hospedeiro-Parasita/imunologia
Seres Humanos
Tolerância Imunológica
Mordeduras e Picadas de Insetos/imunologia
Psychodidae/imunologia
Carrapatos/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171010
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005956


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[PMID]:28818308
[Au] Autor:Düzenli U; Bozan N; Ayral A; Yalinkiliç A; Kiroglu AF
[Ad] Endereço:Yüzüncü Yil University, Faculty of Medicine, Department of Otorhinolaryngology, Van, Turkey. Electronic address: ufukduzenli@yyu.edu.tr.
[Ti] Título:A honey bee can threat ear: Sudden sensorineural hearing loss.
[So] Source:Am J Emerg Med;35(11):1788.e1-1788.e3, 2017 Nov.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sudden sensorineural hearing loss is an otologic emergency. Many etiological factors can lead to this pathology. Honey bee (Apis mellifera) sting may lead to local and systemic reactions due to sensitization of the patient. In this paper we described a sudden sensorineural hearing loss occurred after honey bee sting.
[Mh] Termos MeSH primário: Perda Auditiva Súbita/etiologia
Hipersensibilidade/etiologia
Mordeduras e Picadas de Insetos/complicações
[Mh] Termos MeSH secundário: Betametasona/uso terapêutico
Dexametasona/uso terapêutico
Dispneia/etiologia
Glucocorticoides/uso terapêutico
Perda Auditiva Súbita/tratamento farmacológico
Perda Auditiva Súbita/fisiopatologia
Testes Auditivos
Antagonistas dos Receptores Histamínicos H1/uso terapêutico
Seres Humanos
Hipersensibilidade/tratamento farmacológico
Injeção Intratimpânica
Mordeduras e Picadas de Insetos/tratamento farmacológico
Masculino
Metilprednisolona/uso terapêutico
Náusea/etiologia
Feniramina/uso terapêutico
Zumbido/etiologia
Vômito/etiologia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (Histamine H1 Antagonists); 134FM9ZZ6M (Pheniramine); 7S5I7G3JQL (Dexamethasone); 9842X06Q6M (Betamethasone); X4W7ZR7023 (Methylprednisolone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE


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[PMID]:28817629
[Au] Autor:Niare S; Almeras L; Tandina F; Yssouf A; Bacar A; Toilibou A; Doumbo O; Raoult D; Parola P
[Ad] Endereço:Aix Marseille Université, Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), UM63, CNRS 7278, IRD 198 (Dakar, Sénégal), Inserm 1095, AP-HM, IHU Méditerranée Infection, Marseille, France.
[Ti] Título:MALDI-TOF MS identification of Anopheles gambiae Giles blood meal crushed on Whatman filter papers.
[So] Source:PLoS One;12(8):e0183238, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Identification of the source of mosquito blood meals is an important component for disease control and surveillance. Recently, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) profiling has emerged as an effective tool for mosquito blood meal identification, using the abdomens of freshly engorged mosquitoes. In the field, mosquito abdomens are crushed on Whatman filter papers to determine the host feeding patterns by identifying the origin of their blood meals. The aim of this study was to test whether crushing engorged mosquito abdomens on Whatman filter papers was compatible with MALDI-TOF MS for mosquito blood meal identification. Both laboratory reared and field collected mosquitoes were tested. MATERIAL AND METHODS: Sixty Anopheles gambiae Giles were experimentally engorged on the blood of six distinct vertebrate hosts (human, sheep, rabbit, dog, chicken and rat). The engorged mosquito abdomens were crushed on Whatman filter papers for MALDI-TOF MS analysis. 150 Whatman filter papers, with mosquitoes engorged on cow and goat blood, were preserved. A total of 77 engorged mosquito abdomens collected in the Comoros Islands and crushed on Whatman filter papers were tested with MALDI-TOF MS. RESULTS: The MS profiles generated from mosquito engorged abdomens crushed on Whatman filter papers exhibited high reproducibility according to the original host blood. The blood meal host was correctly identified from mosquito abdomens crushed on Whatman filter papers by MALDI-TOF MS. The MS spectra obtained after storage were stable regardless of the room temperature and whether or not they were frozen. The MS profiles were reproducible for up to three months. For the Comoros samples, 70/77 quality MS spectra were obtained and matched with human blood spectra. This was confirmed by molecular tools. CONCLUSION: The results demonstrated that MALDI-TOF MS could identify mosquito blood meals from Whatman filter papers collected in the field during entomological surveys. The application of MALDI-TOF MS has proved to be rapid and successful, making it a new and efficient tool for mosquito-borne disease surveillance.
[Mh] Termos MeSH primário: Anopheles/fisiologia
Comportamento Alimentar
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz/métodos
[Mh] Termos MeSH secundário: Animais
Mordeduras e Picadas de Insetos
Papel
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183238


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[PMID]:28686665
[Au] Autor:Rodríguez-Pérez MA; Garza-Hernández JA; Salinas-Carmona MC; Fernández-Salas I; Reyes-Villanueva F; Real-Najarro O; Cupp EW; Unnasch TR
[Ad] Endereço:Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa, Tamaulipas, México.
[Ti] Título:The esperanza window trap reduces the human biting rate of Simulium ochraceum s.l. in formerly onchocerciasis endemic foci in Southern Mexico.
[So] Source:PLoS Negl Trop Dis;11(7):e0005686, 2017 Jul.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The Esperanza Window Trap (EWT) baited with CO2 and human sweat compounds is attractive to Simulium ochraceum s.l., the primary vector of Onchocerca volvulus in the historically largest endemic foci in México and Guatemala. METHODOLOGY/PRINCIPAL FINDINGS: The ability of the EWT to locally reduce numbers of questing S. ochraceum s.l. was evaluated in two formerly onchocerciasis endemic communities in Southern México. At each community, two EWTs were placed in or near a school or household and flies were collected sequentially for a total of 10 days. Black fly collections were then carried out for an additional 10 days in the absence of the EWTs. Flies were also collected outside the dwellings to control for variations in the local fly populations. When the EWTs were present, there was a significant reduction in the human biting rate at both the household and school locations at collection sites, with a greater effect observed in the schools. CONCLUSIONS/SIGNIFICANCE: These results indicate that the EWTs not only have potential as a black fly monitoring tool but may be used for reducing personal exposure to fly bites in Mesoamerica.
[Mh] Termos MeSH primário: Mordeduras e Picadas de Insetos/epidemiologia
Controle de Insetos/métodos
Oncocercose/prevenção & controle
Simuliidae
[Mh] Termos MeSH secundário: Animais
Entomologia
Interações Hospedeiro-Parasita
Seres Humanos
Insetos Vetores/parasitologia
México
Onchocerca volvulus
Oncocercose/transmissão
Análise de Regressão
Simuliidae/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005686


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[PMID]:28686638
[Au] Autor:Savi E; Incorvaia C; Boni E; Mauro M; Peveri S; Pravettoni V; Quercia O; Reccardini F; Montagni M; Pessina L; Ridolo E
[Ad] Endereço:Allergy Dept. Unit, G. Da Saliceto Hospital, AUSL, Piacenza, Italy.
[Ti] Título:Which immunotherapy product is better for patients allergic to Polistes venom? A laboratory and clinical study.
[So] Source:PLoS One;12(7):e0180270, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Venom immunotherapy (VIT) is highly effective in preventing allergic reactions to insect stings, but the appropriate venom must be used to achieve clinical protection. In patients with multiple positive results to venoms, molecular allergy diagnostics or CAP-inhibition may identify the causative venom. Concerning allergy to venom from Polistes spp. it has been proposed that only the European species P. dominulus should be used for VIT. However, this recommendation is not present in any international guideline. Using both laboratory and clinical data, we aimed to evaluate the reliability of this proposal. METHODS: We performed an in vitro study using CAP-inhibition to determine sensitization of 19 patients allergic to Polistes venom. The clinical study included 191 patients with positive tests to Polistes treated with VIT, 102 were treated with P. dominulus and 89 were treated with a mix of American Polistes (mAP). RESULTS: The difference in % of inhibition was significant concerning inhibition of P. dominulus sIgE by P. dominulus venom (79.8%) compared with inhibition by mAP venom (64.2%) and not significant concerning the inhibition of mAP sIgE by P. dominulus venom (80.1%) and by mAP venom (73.6%). Instead, the clinical protection from stings was not statistically different between the two kinds of venom. CONCLUSION: The data from CAP inhibition would suggest that the choice of either P. dominulus venom or mAP venom for VIT is appropriate in patients with CAP inhibition higher than 70%, but the clinical data show the same odds of protection from stings using for VIT P. dominulus or mAP venom.
[Mh] Termos MeSH primário: Alérgenos/administração & dosagem
Dessensibilização Imunológica/métodos
Hipersensibilidade Imediata/terapia
Mordeduras e Picadas de Insetos/terapia
Venenos de Vespas/administração & dosagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Alérgenos/química
Alérgenos/imunologia
Animais
Europa (Continente)
Seres Humanos
Hipersensibilidade Imediata/imunologia
Hipersensibilidade Imediata/fisiopatologia
Imunoglobulina E/sangue
Mordeduras e Picadas de Insetos/imunologia
Mordeduras e Picadas de Insetos/fisiopatologia
Meia-Idade
Especificidade da Espécie
Estados Unidos
Venenos de Vespas/química
Venenos de Vespas/imunologia
Vespas/química
Vespas/imunologia
[Pt] Tipo de publicação:CLINICAL STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Wasp Venoms); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180270


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[PMID]:28643726
[Au] Autor:Kim WJ; Kim S; Kim MM
[Ad] Endereço:Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, South Korea.
[Ti] Título:Exotropia in a pediatric patient with rhabdomyolysis caused by an insect sting.
[So] Source:Indian J Ophthalmol;65(6):535-537, 2017 Jun.
[Is] ISSN:1998-3689
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Various ocular and systemic reactions have been associated with insect sting. However, insect stings have been rarely reported to cause exotropia and diplopia. We encountered exotropia in a 6-year-old child with rhabdomyolysis of the left lower extremities caused by an insect sting. Exotropia and diplopia developed within 1 day after the sting and improved completely 1 week after the onset of symptoms. Clinicians should be aware of the potential for the development of exotropia in patients with insect stings, which requires careful follow-up.
[Mh] Termos MeSH primário: Exotropia/etiologia
Movimentos Oculares/fisiologia
Mordeduras e Picadas de Insetos/complicações
Rabdomiólise/complicações
[Mh] Termos MeSH secundário: Criança
Diagnóstico Diferencial
Exotropia/diagnóstico
Exotropia/fisiopatologia
Seguimentos
Seres Humanos
Imagem Tridimensional
Mordeduras e Picadas de Insetos/diagnóstico
Extremidade Inferior/lesões
Masculino
Rabdomiólise/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.4103/ijo.IJO_600_16


  9 / 5429 MEDLINE  
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Texto completo SciELO Brasil
[PMID]:28591253
[Au] Autor:Silva GBD; Vasconcelos AG; Rocha AMT; Vasconcelos VR; Barros J; Fujishima JS; Ferreira NB; Barros EJG; Daher EF
[Ad] Endereço:Universidade de Fortaleza, Faculdade de Medicina, Centro de Ciências da Saúde, Fortaleza, Ceará, Brazil.
[Ti] Título:Acute kidney injury complicating bee stings - a review.
[So] Source:Rev Inst Med Trop Sao Paulo;59:e25, 2017 Jun 01.
[Is] ISSN:1678-9946
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Bee stings can cause severe reactions and have caused many victims in the last years. Allergic reactions can be triggered by a single sting and the greater the number of stings, the worse the prognosis. The poisoning effects can be systemic and can eventually cause death. The poison components are melitin, apamin, peptide 401, phospholipase A2, hyaluronidase, histamine, dopamine, and norepinephrine, with melitin being the main lethal component. Acute kidney injury (AKI) can be observed in patients suffering from bee stings and this is due to multiple factors, such as intravascular hemolysis, rhabdomyolysis, hypotension and direct toxicity of the venom components to the renal tubules. Arterial hypotension plays an important role in this type of AKI, leading to ischemic renal lesion. The most commonly identified biopsy finding in these cases is acute tubular necrosis, which can occur due to both, ischemic injury and the nephrotoxicity of venom components. Hemolysis and rhabdomyolysis reported in many cases in the literature, were demonstrated by elevated serum levels of indirect bilirubin and creatine kinase. The severity of AKI seems to be associated with the number of stings, since creatinine levels were higher, in most cases, when there were more than 1,000 stings. The aim of this study is to present an updated review of AKI associated with bee stings, including the currently advised clinical approach.
[Mh] Termos MeSH primário: Lesão Renal Aguda/etiologia
Venenos de Abelha/envenenamento
Abelhas
Mordeduras e Picadas de Insetos/complicações
[Mh] Termos MeSH secundário: Lesão Renal Aguda/fisiopatologia
Lesão Renal Aguda/terapia
Animais
Venenos de Abelha/química
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Bee Venoms)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170705
[Lr] Data última revisão:
170705
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE


  10 / 5429 MEDLINE  
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[PMID]:28501976
[Au] Autor:Tomsitz D; Brockow K
[Ad] Endereço:Department of Dermatology and Allergy Biederstein, Technische Universität München, Biedersteiner Straße 29, 80802, Munich, Germany.
[Ti] Título:Component Resolved Diagnosis in Hymenoptera Anaphylaxis.
[So] Source:Curr Allergy Asthma Rep;17(6):38, 2017 Jun.
[Is] ISSN:1534-6315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: Hymenoptera anaphylaxis is one of the leading causes of severe allergic reactions and can be fatal. Venom-specific immunotherapy (VIT) can prevent a life-threatening reaction; however, confirmation of an allergy to a Hymenoptera venom is a prerequisite before starting such a treatment. Component resolved diagnostics (CRD) have helped to better identify the responsible allergen. RECENT FINDINGS: Many new insect venom allergens have been identified within the last few years. Commercially available recombinant allergens offer new diagnostic tools for detecting sensitivity to insect venoms. Additional added sensitivity to nearly 95% was introduced by spiking yellow jacket venom (YJV) extract with Ves v 5. The further value of CRD for sensitivity in YJV and honey bee venom (HBV) allergy is more controversially discussed. Recombinant allergens devoid of cross-reactive carbohydrate determinants often help to identify the culprit venom in patients with double sensitivity to YJV and HBV. CRD identified a group of patients with predominant Api m 10 sensitization, which may be less well protected by VIT, as some treatment extracts are lacking this allergen. The diagnostic gap of previously undetected Hymenoptera allergy has been decreased via production of recombinant allergens. Knowledge of analogies in interspecies proteins and cross-reactive carbohydrate determinants is necessary to distinguish relevant from irrelevant sensitizations.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Anafilaxia/diagnóstico
Venenos de Abelha/imunologia
Himenópteros/imunologia
Venenos de Vespas/imunologia
[Mh] Termos MeSH secundário: Anafilaxia/imunologia
Animais
Reações Cruzadas
Seres Humanos
Imunoglobulina E/imunologia
Mordeduras e Picadas de Insetos/diagnóstico
Mordeduras e Picadas de Insetos/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Allergens); 0 (Bee Venoms); 0 (Wasp Venoms); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170515
[St] Status:MEDLINE
[do] DOI:10.1007/s11882-017-0707-0



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