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[PMID]:29202704
[Au] Autor:Antonise-Kamp L; Beaujean DJMA; Crutzen R; van Steenbergen JE; Ruwaard D
[Ad] Endereço:National Institute for Public Health and the Environment, Centre for Infectious Disease Control, P.O. Box 1, 3720, BA, Bilthoven, the Netherlands. laura.kamp@rivm.nl.
[Ti] Título:Prevention of tick bites: an evaluation of a smartphone app.
[So] Source:BMC Infect Dis;17(1):744, 2017 12 04.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Lyme borreliosis (LB) is the most common reported tick-borne infection in Europe, and involves transmission of Borrelia by ticks. As long as a vaccine is not available and effective measures for controlling tick populations are insufficient, LB control is focused on preventive measures to avoid tick bites. To inform citizens about the risk of ticks, motivate them to check for tick bites, and encourage them to remove any attached tick as quickly as possible, a mobile app called 'Tekenbeet' (Dutch for 'tick bite') was developed and released. The aim of this study was to evaluate the usage and user satisfaction of the 'Tekenbeet' app and to investigate whether it affects users' knowledge, perceived severity, perceived susceptibility, self-efficacy, response efficacy, current behavior and intention to comply with preventive measures. METHODS: Usage of the app was evaluated with data obtained from Google Analytics. A survey among the Dutch general adult population with two data collection periods evaluated the usage, user satisfaction and its influence on abovementioned outcomes. RESULTS: Data obtained from Google Analytics showed the app was downloaded almost 40,000 in the 20 months following the launch. The 'tick radar' and 'tick diary' screens were viewed most often. In addition, a total of 554 respondents completed an online survey. The mean user satisfaction score was 7.44 (on a scale of 1-10) and 90.9% of respondents would recommend the app to others. On average, survey respondents who downloaded the app (n = 243) recorded significantly more often higher knowledge scores (OR 3.37; 95% CI 2.02-5.09) and had a higher intention to comply with preventive measures (OR 2.47; 95% CI 1.22-5.85) compared to respondents who did not download the app (n = 311). CONCLUSIONS: The 'Tekenbeet' app is a frequently used and well-appreciated educational tool to increase public knowledge of ticks and tick bites. It also helps to improve the user's intention to apply preventive measures. The use of smartphones and apps is now commonplace in the Netherlands; the 'Tekenbeet' app feeds into this trend and thereby offers a modern day alternative to established formats such as an information leaflet and information provision on the Internet.
[Mh] Termos MeSH primário: Doença de Lyme/prevenção & controle
Aplicativos Móveis
Smartphone
Picadas de Carrapatos
[Mh] Termos MeSH secundário: Adulto
Animais
Comportamento do Consumidor/estatística & dados numéricos
Feminino
Seres Humanos
Doença de Lyme/epidemiologia
Masculino
Meia-Idade
Aplicativos Móveis/estatística & dados numéricos
Aplicativos Móveis/utilização
Países Baixos/epidemiologia
Projetos Piloto
Smartphone/utilização
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2836-4


  2 / 190 MEDLINE  
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[PMID]:29320145
[Au] Autor:Krstic M; Stajkovic N; Lazic S
[Ti] Título:Prevalence of Borrelia burgdorferi sensu lato in Ixodes ricinus ticks and assessment of entomological risk index at localities in Belgrade.
[So] Source:Vojnosanit Pregl;73(9):817-24, 2016 Sep.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: The first case of human Lyme borreliosis (LB) in Serbia was recorded in 1987. The number of reported LB cases has increased in the past decade. The aim of this study was to estimate the density of Ixodes ricinus (I. ricinus) ticks, the prevalence of Borrelia burgdorferi sensu lato (B. burgdorferi) in them, and entomological risk index (ERI) at 19 Belgrade localities which were grouped into three categories (forests, parkforests, parks). The values of ERI were compared with the number of tick bites in humans. Methods: Ticks were collected monthly by using the flag hours method and the infection rate was determined by using dark field microscopy. The ERI value was calculated for each locality where the ticks were collected. The related data about tick bites was obtained from the patient protocol of the Institute of Epidemiology, Military Medical Academy, Belgrade. Results: The total number of collected ticks, the number of nymphs and the infection rates of the nymphs were significantly higher in forests (p < 0.05) than park-forests and parks. Statistically, the ERI value was significantly higher in forests than parks of Belgrade (χ2 = 7.78, p < 0.01). In March and July, the ERI value was also significantly higher in forests, than park-forests (p < 0.01) and parks (p < 0.01). May was the month with the highest ERI value in each ecological category (forests p < 0.05; park-forests p < 0.01; parks p < 0.001). However, the number of tick bites in humans did not correlate with ERI values. Conclusion: The obtained results indicate that the risk of tick bite and human exposure to B. burgdorferi sensu lato is present at all selected localities in Belgrade. For a more comprehensive Lyme disease risk assessment the method of entomological risk index assessment should be combined with other methods, taking into consideration all tick stages and the behaviour and habits of people who may get infected B. burgdorferi sensu lato.
[Mh] Termos MeSH primário: Borrelia burgdorferi/isolamento & purificação
Ixodes/microbiologia
Ixodes/parasitologia
Doença de Lyme/microbiologia
Picadas de Carrapatos/microbiologia
Zoonoses/microbiologia
[Mh] Termos MeSH secundário: Animais
Florestas
Seres Humanos
Doença de Lyme/diagnóstico
Doença de Lyme/epidemiologia
Doença de Lyme/transmissão
Parques Recreativos
Medição de Risco
Fatores de Risco
Estações do Ano
Sérvia/epidemiologia
Picadas de Carrapatos/diagnóstico
Picadas de Carrapatos/epidemiologia
Fatores de Tempo
Saúde da População Urbana
Zoonoses/diagnóstico
Zoonoses/epidemiologia
Zoonoses/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150115069K


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[PMID]:29236732
[Au] Autor:Embers ME; Hasenkampf NR; Jacobs MB; Tardo AC; Doyle-Meyers LA; Philipp MT; Hodzic E
[Ad] Endereço:Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA, United States of America.
[Ti] Título:Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding.
[So] Source:PLoS One;12(12):e0189071, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The efficacy and accepted regimen of antibiotic treatment for Lyme disease has been a point of significant contention among physicians and patients. While experimental studies in animals have offered evidence of post-treatment persistence of Borrelia burgdorferi, variations in methodology, detection methods and limitations of the models have led to some uncertainty with respect to translation of these results to human infection. With all stages of clinical Lyme disease having previously been described in nonhuman primates, this animal model was selected in order to most closely mimic human infection and response to treatment. Rhesus macaques were inoculated with B. burgdorferi by tick bite and a portion were treated with recommended doses of doxycycline for 28 days at four months post-inoculation. Signs of infection, clinical pathology, and antibody responses to a set of five antigens were monitored throughout the ~1.2 year study. Persistence of B. burgdorferi was evaluated using xenodiagnosis, bioassays in mice, multiple methods of molecular detection, immunostaining with polyclonal and monoclonal antibodies and an in vivo culture system. Our results demonstrate host-dependent signs of infection and variation in antibody responses. In addition, we observed evidence of persistent, intact, metabolically-active B. burgdorferi after antibiotic treatment of disseminated infection and showed that persistence may not be reflected by maintenance of specific antibody production by the host.
[Mh] Termos MeSH primário: Borrelia burgdorferi/fisiologia
Ixodes/microbiologia
Primatas/parasitologia
[Mh] Termos MeSH secundário: Animais
Ixodes/fisiologia
Camundongos
Picadas de Carrapatos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189071


  4 / 190 MEDLINE  
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[PMID]:27771334
[Au] Autor:Aenishaenslin C; Bouchard C; Koffi JK; Ogden NH
[Ad] Endereço:Groupe de Recherche en Épidémiologie des Zoonoses et Santé Publique (GREZOSP), Faculté de médecine vétérinaire, Université de Montréal, CP 5000, Saint-Hyacinthe, J2S 7C6, Québec, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, 1140 Pine Avenue, Montreal
[Ti] Título:Exposure and preventive behaviours toward ticks and Lyme disease in Canada: Results from a first national survey.
[So] Source:Ticks Tick Borne Dis;8(1):112-118, 2017 01.
[Is] ISSN:1877-9603
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Lyme disease (LD) risk is increasing in Canada. In 2014, the government of Canada launched a national communication campaign to raise awareness and promote the adoption of individual preventive behaviours toward ticks and LD. The objectives of this study were to evaluate and compare the adoption of LD preventive behaviours and the exposure to tick bites of Canadians in the five main targeted regions (British Columbia, Prairie provinces, Ontario, Quebec and the Atlantic provinces). A national survey was conducted in December 2014 (n=2876) to collect data on LD awareness, behaviours and risk factors. Overall, the proportion of respondents reporting tick exposure was high (20%). The results suggest that even though LD awareness was found to be high (with only 12% of the respondents reporting that they never heard about LD), less than half of the Canadians who heard about it have adopted specific preventive behaviours toward tick bites, such as regular tick checks (reported by 52%), protective clothing (50%), using tick repellent (41%) or shower or bath (41%) after visiting a wooded area in a LD risk area. Moreover, significant differences were found between regions, gender, age groups and dog ownership status, regarding preventive behaviours and factors of exposure. A high level of knowledge of Lyme disease, living in the Prairie region, as well as having found a tick on oneself or a relative, were found to be associated with the adoption of preventive behaviours. This study underlines the importance to take into account specific regional characteristics of risk and to maintain public health communication efforts through time in order to increase the adoption of preventive behaviours of Canadians.
[Mh] Termos MeSH primário: Conhecimentos, Atitudes e Prática em Saúde
Doença de Lyme/prevenção & controle
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Animais
Canadá/epidemiologia
Coleta de Dados
Feminino
Seres Humanos
Doença de Lyme/epidemiologia
Masculino
Meia-Idade
Fatores Socioeconômicos
Inquéritos e Questionários
Picadas de Carrapatos/prevenção & controle
Controle de Ácaros e Carrapatos
Carrapatos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28829732
[Au] Autor:Kim CM; Kim SW; Kim DM; Yoon NR; Jha P; Jang SJ; Ahn YJ; Lim D; Lee SH; Hwang SD; Lee YS
[Ad] Endereço:Premedical Science, College of Medicine, Chosun University, Gwangju, Republic of Korea.
[Ti] Título:Case Report: Polymerase Chain Reaction Testing of Tick Bite Site Samples for the Diagnosis of Human Granulocytic Anaplasmosis.
[So] Source:Am J Trop Med Hyg;97(2):403-406, 2017 Aug.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human granulocytic anaplasmosis (HGA) is a tick-borne infectious disease caused by , an obligate intracellular bacterium. Until now, the utility of tick-bite site samples for HGA diagnosis has not been reported. Using a patient's buffy coat and tick-bite site crust samples, we performed polymerase chain reaction (PCR) testing using - or -specific primers. PCR with buffy coat and crust samples obtained before doxycycline administration was positive. Six days after doxycycline administration, PCR with the buffy coat sample was negative but PCR with a crust tissue sample from the tick-bite site remained positive. This is the first case to suggest that crust tissue at the tick-bite site may be useful for early HGA diagnosis in patients who have already been treated with antibiotics such as doxycycline.
[Mh] Termos MeSH primário: Anaplasmose/sangue
Anaplasmose/microbiologia
Picadas de Carrapatos/sangue
Picadas de Carrapatos/microbiologia
Doenças Transmitidas por Carrapatos/sangue
Doenças Transmitidas por Carrapatos/microbiologia
[Mh] Termos MeSH secundário: Idoso
Anaplasma phagocytophilum
Anaplasmose/diagnóstico
Diagnóstico Precoce
Seres Humanos
Masculino
Reação em Cadeia da Polimerase
República da Coreia
Doenças Transmitidas por Carrapatos/diagnóstico
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0570


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[PMID]:28722598
[Au] Autor:Mareedu N; Schotthoefer AM; Tompkins J; Hall MC; Fritsche TR; Frost HM
[Ad] Endereço:Marshfield Clinic Health System, Marshfield, Wisconsin.
[Ti] Título:Risk Factors for Severe Infection, Hospitalization, and Prolonged Antimicrobial Therapy in Patients with Babesiosis.
[So] Source:Am J Trop Med Hyg;97(4):1218-1225, 2017 Oct.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Babesiosis is an emerging tick-borne disease transmitted by the hard tick , which also transmits Lyme disease. Better gradation of prognostic indicators are needed to determine which patients may develop serious complications requiring hospitalization, and to provide early guidance on appropriate therapy. In this study, we evaluated 128 patients with smear or real time polymerase chain reaction-confirmed infections over a period of 16 years. Patients with asplenia or immunocompromising conditions were more likely to have severe infection ( < 0.01), require hospitalization ( < 0.01), or receive prolonged courses of antimicrobials ( < 0.01). Nausea or vomiting ( < 0.01) and diarrhea ( < 0.01) along with hyperbilirubinemia ( < 0.01) were predictive of severe infection, hospitalization, and prolonged antimicrobial therapy. Patients with concurrent Lyme disease were less likely to require hospitalization and had similar severity of disease and length of antibiotic treatment compared with those without Lyme disease.
[Mh] Termos MeSH primário: Antiprotozoários/administração & dosagem
Antiprotozoários/uso terapêutico
Babesiose/tratamento farmacológico
Babesiose/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Babesia/isolamento & purificação
Babesiose/epidemiologia
Esquema de Medicação
Feminino
Seres Humanos
Masculino
Meia-Idade
Fatores de Risco
Picadas de Carrapatos
Wisconsin/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.17-0146


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[PMID]:28678811
[Au] Autor:Hu J; Li Z; Hong L; Bao C; Zhang Z; Zhang H; He H; Wang X; Liu W; Peng Z; Shi L; Zhu F
[Ad] Endereço:Department of Acute Infectious Disease Control and Prevention, Jiangsu provincial Center for Disease Control and Prevention, Nanjing, China.
[Ti] Título:Preliminary fast diagnosis of severe fever with thrombocytopenia syndrome with clinical and epidemiological parameters.
[So] Source:PLoS One;12(7):e0180256, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To identify specific clinical and epidemiological parameters for clinical diagnosis of SFTSV infection with relatively higher accuracy. METHODS: 231 suspected cases of SFTS were reported by various medical institutions from 2011 to 2013 in Jiangsu Province, China. They were followed with SFTSV diagnosis tests and interview-administered questionnaires about demographic characteristics, clinical symptoms and epidemiological exposure factors. Univariate and multivariable logistic regression analysis were used to examine the diagnostic value of these parameters. RESULTS: SFTSV infection occurred only from April to October annually and usually in hilly areas of specific regions. Three prediction models of SFTSV infection were constructed. Model 3 with clinical and epidemiological parameters combined the benefits of both Model 1and Model 2, which was optimal and had an overall accuracy of 80.2%. Independent indicators for clinical diagnosis of SFTSV infection in Model 3 were as follows: lymphadenopathy (P = 0.01), leucopenia (P<0.01), age >50 years (P = 0.01), tick bites (P<0.01), raising domestic animals in the residential areas (P<0.01) and farming (P = 0.03). CONCLUSIONS: Our results show that using a combination of clinical and epidemiological parameters may be a feasible strategy to provide preliminary fast diagnosis as differentiating SFTSV infection from SFTS-like diseases, thus reducing the risk of misdiagnosis.
[Mh] Termos MeSH primário: Infecções por Bunyaviridae/diagnóstico
Programas de Rastreamento/métodos
Febre por Flebótomos/diagnóstico
Trombocitopenia/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Agricultura
Animais
Bunyaviridae/fisiologia
Infecções por Bunyaviridae/epidemiologia
Infecções por Bunyaviridae/virologia
China/epidemiologia
Estudos de Viabilidade
Feminino
Geografia
Interações Hospedeiro-Patógeno
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Análise Multivariada
Febre por Flebótomos/epidemiologia
Febre por Flebótomos/virologia
Inquéritos e Questionários
Síndrome
Trombocitopenia/epidemiologia
Trombocitopenia/virologia
Picadas de Carrapatos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180256


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[PMID]:28612350
[Au] Autor:Hvidsten D; Mortensen L; Straume B; Arsenovic MG; Pedersen AB; Lyngås G; Gray JS; Grude N
[Ad] Endereço:Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway.
[Ti] Título:Blood donor Borrelia burgdorferi sensu lato seroprevalence and history of tick bites at a northern limit of the vector distribution.
[So] Source:APMIS;125(8):717-724, 2017 Aug.
[Is] ISSN:1600-0463
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:In order to study the antibody seroprevalence of the causal agent of Lyme borreliosis, Borrelia burgdorferi sensu lato (s.l.), and the history of tick bites at a geographical distribution limit of Ixodes ricinus, we compared healthy blood donors in geographically extreme regions: the borreliosis-endemic Vestfold County (59°N) and the region of northern Norway. Blood samples were screened using IgG/VlsE ELISA, and positive/borderline samples were confirmed using C6 ELISA and immunoblot assays. Also, donors completed a questionnaire consisting of several items including the places they have lived, and whether they owned any pets. The seroprevalence was 0.48% (5/1048) in northern Norway and 9.25% (48/519) in Vestfold County. Seven donors (of 1048) had experienced a single tick bite in the southern part of Nordland County (65°N) in northern Norway. This first study on B. burgdorferi s.l. antibody seroprevalence and tick bites on humans and pets in northern Norway showed that the seroprevalence of B. burgdorferi s.l. infection and the risk of tick bite in northern Norway are insignificant; the fact that only five positive IgG samples were detected underscores the very low background seroprevalence. These results suggest that so far I. ricinus has not expanded north of the previously established geographical distribution limit.
[Mh] Termos MeSH primário: Anticorpos Antibacterianos/sangue
Grupo Borrelia Burgdorferi/imunologia
Ixodes/crescimento & desenvolvimento
Doença de Lyme/epidemiologia
Picadas de Carrapatos/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Animais
Doadores de Sangue
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Immunoblotting
Imunoglobulina G/sangue
Doença de Lyme/imunologia
Masculino
Meia-Idade
Noruega/epidemiologia
Estudos Soroepidemiológicos
Inquéritos e Questionários
Picadas de Carrapatos/complicações
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Immunoglobulin G)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12708


  9 / 190 MEDLINE  
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[PMID]:28443380
[Au] Autor:Rizer J; Brill K; Charlton N; King J
[Ad] Endereço:a Department of Emergency Medicine, Division of Medical Toxicology , University of Virginia , Charlottesville , VA , USA.
[Ti] Título:Acute hypersensitivity reaction to Crotalidae polyvalent immune Fab (CroFab) as initial presentation of galactose-α-1,3-galactose (α-gal) allergy.
[So] Source:Clin Toxicol (Phila);55(7):668-669, 2017 Aug.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Crotalidae polyvalent immune Fab antivenom (CroFab), commonly used for the treatment of clinically significant North American crotalinae envenomation, is generally well-tolerated. A novel form of anaphylaxis due to an IgE antibody response to the mammalian oligosaccharide galactose-α-1,3-galactose (α-gal) has been established following red-meat consumption as well as IV administration of cetuximab, which contain the α-gal epitope. We present a case of α-gal allergy discovered after acute hypersensitivity reaction to FabAV. A 61-year-old healthy female was bitten on her left ankle by Agkistrodon contortrix. Given the patient's rapid progression of pain and swelling, she was given FabAV. During infusion of FabAV, she developed diffuse hives over her entire body and itching, but denied respiratory or gastrointestinal symptoms and her vital signs remained stable. The FabAV was immediately discontinued and she received intravenous diphenhydramine and famotidine with gradual resolution of symptoms. On further discussion, she denied a history of α-gal or papaya allergy but rarely ate red meat and endorsed sustaining frequent tick bites. Subsequent antibody testing was significant for an α-1,3-galactose IgE concentration of 45,000 U/L (normal <3500 U/L), confirming α-gal allergy. To our knowledge, this is the first report of FabAV hypersensitivity associated with an underlying α-gal allergy.
[Mh] Termos MeSH primário: Agkistrodon/imunologia
Antivenenos/efeitos adversos
Venenos de Crotalídeos/imunologia
Dissacarídeos/imunologia
Hipersensibilidade a Drogas/etiologia
Fragmentos Fab das Imunoglobulinas/efeitos adversos
Mordeduras de Serpentes/tratamento farmacológico
Picadas de Carrapatos/imunologia
Urticária/induzido quimicamente
[Mh] Termos MeSH secundário: Animais
Antialérgicos/administração & dosagem
Hipersensibilidade a Drogas/diagnóstico
Hipersensibilidade a Drogas/tratamento farmacológico
Hipersensibilidade a Drogas/imunologia
Feminino
Seres Humanos
Testes Imunológicos
Meia-Idade
Valor Preditivo dos Testes
Mordeduras de Serpentes/diagnóstico
Mordeduras de Serpentes/imunologia
Resultado do Tratamento
Urticária/diagnóstico
Urticária/tratamento farmacológico
Urticária/imunologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Agkistrodon venoms); 0 (Anti-Allergic Agents); 0 (Antivenins); 0 (Crotalid Venoms); 0 (Crotalidae Polyvalent immune Fab); 0 (Disaccharides); 0 (Immunoglobulin Fab Fragments); 13168-24-6 (galactosyl-(1-3)galactose)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1080/15563650.2017.1313981


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[PMID]:28423486
[Au] Autor:Mateos-Hernández L; Villar M; Moral A; Rodríguez CG; Arias TA; de la Osa V; Brito FF; Fernández de Mera IG; Alberdi P; Ruiz-Fons F; Cabezas-Cruz A; Estrada-Peña A; de la Fuente J
[Ad] Endereço:SaBio, Instituto de Investigación de Recursos Cinegéticos, IREC-CSIC-UCLM-JCCM, Ciudad Real, Spain.
[Ti] Título:Tick-host conflict: immunoglobulin E antibodies to tick proteins in patients with anaphylaxis to tick bite.
[So] Source:Oncotarget;8(13):20630-20644, 2017 Mar 28.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tick-borne infectious diseases and allergies are a growing problem worldwide. Tick bite allergy has been associated with the direct effect of immunoglobulin E (IgE) response to tick salivary antigens, or secondary to the induction of allergy to red meat consumption through IgE antibodies against the carbohydrate α-Gal (Gal α 1-3Gal ß 1-(3)4GlcNAc-R). However, despite the growing burden of this pathology, the proteins associated with anaphylaxis to tick bite have not been characterized. To address this question, a comparative proteomics approach was used to characterize tick proteins producing an IgE antibody response in a healthy individual with record of tick bites, which had not resulted in any allergic reactions, and two patients with anaphylactic reactions to Rhipicephalus bursa or Hyalomma marginatum tick bites. Both patients and the healthy individual were red meat tolerant. The results supported a patient-specific IgE antibody response to tick species responsible for the anaphylaxis to tick bite. Both patients and the healthy individual serologically recognized tick proteins with and without α-Gal modifications, with proteins differentially recognized by patients but not control sera. These proteins could be used as potential antigens for diagnostics, treatment and prevention of tick bite-induced allergies.
[Mh] Termos MeSH primário: Anafilaxia/imunologia
Proteínas de Artrópodes/imunologia
Imunoglobulina E/imunologia
Picadas de Carrapatos/imunologia
Carrapatos/imunologia
[Mh] Termos MeSH secundário: Animais
Antígenos/imunologia
Western Blotting
Eletroforese em Gel Bidimensional
Seres Humanos
Masculino
Meia-Idade
Proteômica
Picadas de Carrapatos/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens); 0 (Arthropod Proteins); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.15243



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