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[PMID]:29465576
[Au] Autor:Diao Y; Sun Y; Wang S; Zhang F; Pan S; Liu Z
[Ad] Endereço:Department of Orthopaedics, Peking University Third Hospital, Beijing, China. Beijing Key Laboratory of Spinal Disease, Beijing, China.
[Ti] Título:Delayed epidural pseudoaneurysm following cervical laminectomy and instrumentation in a patient with canal stenosis secondary to skeletal fluorosis: A case report.
[So] Source:Medicine (Baltimore);97(8):e9883, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: The typical intraoperative presentation of vertebral artery injury (VAI) usually involves profuse bleeding and requires immediate treatment. However, an occult VAI may occur intraoperatively and result in delayed life-threatening epidural pseudoaneurysm several days postoperatively. PATIENT CONCERNS: A 21-year-old man with compressive cervical myelopathy resulting from canal stenosis of skeletal fluorosis underwent decompression of C1 to C7 and instrumentation from C2 to C7. No impressive bleeding event occurred during the operation. On postoperative day 40, progressive quadriplegia developed. DIAGNOSES: Pseudoaneurysm of the VA was established by angiography. INTERVENTIONS: After occlusion of the right VA, the patient underwent hematoma clearing. OUTCOMES: Fortunately, the patient experienced significant recovery of neurologic function after the second surgery. LESSONS: From this case, we realize even in the absence of obvious signs of VAI during a cervical operation, postoperative evaluation should be mandatory for suspected bleeding events occurring at VAI-prone sites during surgery. Moreover, the bone morphological abnormality of skeletal fluorosis was determined to be the most important risk contributing to VAI in this case. The safety limits of bone removal should be determined preoperatively to avoid the effects of bone morphological abnormalities.
[Mh] Termos MeSH primário: Falso Aneurisma/etiologia
Doenças Ósseas/complicações
Vértebras Cervicais/cirurgia
Intoxicação por Flúor/complicações
Laminectomia/efeitos adversos
Compressão da Medula Espinal/cirurgia
Estenose Espinal/cirurgia
Artéria Vertebral/lesões
[Mh] Termos MeSH secundário: Constrição Patológica
Seres Humanos
Complicações Intraoperatórias
Masculino
Complicações Pós-Operatórias
Compressão da Medula Espinal/etiologia
Estenose Espinal/etiologia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009883


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[PMID]:28687488
[Au] Autor:Yang H; Xing R; Liu S; Yu H; Li P
[Ad] Endereço:Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
[Ti] Título:Rescuing fluoride-induced damages in liver with gamma aminobutyric acid.
[So] Source:Biochem Biophys Res Commun;491(1):19-24, 2017 Sep 09.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fluorine poisoning affects human health all over the world and an urgent task is to develop alleviative medicine to recover or ameliorate the damages to the body. Here we studied the effects of gamma-aminobutyric acid (GABA), a liver protector reported previously, on fluoride-induced damage in the mouse liver. Through microscope imaging of the liver tissue, TUNEL immunostaining, real-time RT-PCR, enzyme immunoassay and colorimetric method, we found that GABA supplementation prevented the metabolic toxicity caused by fluoride treatment in mice. This detoxification was reflected by the reduced oxidative stress and apoptosis, enhanced neuron protection and liver function. Collectively, this study provided evidence of the beneficial effects of GABA supplement on liver damage, implicating its therapeutic potential in fluorosis.
[Mh] Termos MeSH primário: Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Intoxicação por Flúor/tratamento farmacológico
Intoxicação por Flúor/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Ácido gama-Aminobutírico/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Doença Hepática Induzida por Substâncias e Drogas/patologia
Intoxicação por Flúor/patologia
Inativação Metabólica/efeitos dos fármacos
Masculino
Camundongos
Estresse Oxidativo/efeitos dos fármacos
Resultado do Tratamento
Ácido gama-Aminobutírico/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reactive Oxygen Species); 56-12-2 (gamma-Aminobutyric Acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170709
[St] Status:MEDLINE


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[PMID]:28068725
[Au] Autor:Nissen M; Sander V; Vahdad MR; Thränhardt R; Tröbs RB
[Ad] Endereço:Pediatric Surgery, St. Mary's Hospital, St. Elisabeth Group, Ruhr-University of Bochum, Herne, Germany.
[Ti] Título:Toothpaste-Ingestion in a 4-Year-Old Girl - A Bagatelle Incident?
[Ti] Título:Zahnpastaingestion bei einem 4-jährigen Mädchen ­ Nur eine Bagatelle?.
[So] Source:Klin Padiatr;229(1):46-47, 2017 Jan.
[Is] ISSN:1439-3824
[Cp] País de publicação:Germany
[La] Idioma:eng
[Mh] Termos MeSH primário: Intoxicação por Flúor/diagnóstico
Intoxicação por Flúor/terapia
Pica/complicações
Cremes Dentais/envenenamento
[Mh] Termos MeSH secundário: Cloreto de Cálcio/administração & dosagem
Pré-Escolar
Relação Dose-Resposta a Droga
Endoscopia do Sistema Digestório
Feminino
Mucosa Gástrica/efeitos dos fármacos
Seres Humanos
Soluções Isotônicas/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Isotonic Solutions); 0 (Toothpastes); 8026-10-6 (Ringer's solution); M4I0D6VV5M (Calcium Chloride)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-119710


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[PMID]:27863940
[Au] Autor:Panneerselvam L; Raghunath A; Perumal E
[Ad] Endereço:Molecular Toxicology Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore, Tamil Nadu, India.
[Ti] Título:Acute fluoride poisoning alters myocardial cytoskeletal and AMPK signaling proteins in rats.
[So] Source:Int J Cardiol;229:96-101, 2017 Feb 15.
[Is] ISSN:1874-1754
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Our previous findings revealed that increased oxidative stress, apoptosis and necrosis were implicated in acute fluoride (F ) induced cardiac dysfunction apart from hypocalcemia and hyperkalemia. Cardiac intermediate filaments (desmin and vimentin) and cytoskeleton linker molecule vinculin plays an imperative role in maintaining the architecture of cardiac cytoskeleton. In addition, AMPK is a stress activated kinase that regulates the energy homeostasis during stressed state. The present study was aimed to examine the role of cytoskeletal proteins and AMPK signaling molecules in acute F induced cardiotoxicity in rats. METHODS: In order to study this, male Wistar rats were treated with single oral doses of 45 and 90mg/kgF for 24h. RESULTS: Acute F intoxicated rats showed declined cytoskeletal protein expression of desmin, vimentin and vinculin in a dose dependent manner compared to control. A significant increase in phosphorylation of AMPKα (Thr172), AMPKß1 (Ser108) and Acetyl-coA carboxylase (ACC) (Ser79) in the myocardium and associated ATP deprivation were found in acute F intoxicated rats. Further, ultra-structural studies confirmed myofibril lysis with interruption of Z lines, dilated sarcoplasmic reticulum and damaged mitochondrion were observed in both the groups of F intoxicated rats. CONCLUSION: Taken together, these findings reveal that acute F exposure causes sudden heart failure by altering the expression of cytoskeletal proteins and AMPK signaling molecules.
[Mh] Termos MeSH primário: Proteínas Quinases Ativadas por AMP/metabolismo
Citoesqueleto/metabolismo
Intoxicação por Flúor/metabolismo
Miocárdio/metabolismo
Estresse Oxidativo
[Mh] Termos MeSH secundário: Doença Aguda
Animais
Apoptose
Western Blotting
Modelos Animais de Doenças
Intoxicação por Flúor/patologia
Imuno-Histoquímica
Masculino
Miocárdio/patologia
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.11.31 (AMP-Activated Protein Kinases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161120
[St] Status:MEDLINE


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[PMID]:27655243
[Au] Autor:Sun Y; Ke L; Zheng X; Li T; Ouyang W; Zhang Z
[Ad] Endereço:College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, 321004, People's Republic of China.
[Ti] Título:Effects of Different Levels of Calcium Intake on Brain Cell Apoptosis in Fluorosis Rat Offspring and Its Molecular Mechanism.
[So] Source:Biol Trace Elem Res;176(2):355-366, 2017 Apr.
[Is] ISSN:1559-0720
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of the investigation is to reveal the influence of dietary calcium on fluorosis-induced brain cell apoptosis in rat offspring, as well as the underlying molecular mechanism. Sprague-Dawley (SD) female rats were randomly divided into five groups: control group, fluoride group, low calcium, low calcium fluoride group, and high calcium fluoride group. SD male rats were used for breeding only. After 3 months, male and female rats were mated in a 1:1 ratio. Subsequently, 18-day-old gestation rats and 14- and 28-day-old rats were used as experimental subjects. We determined the blood/urine fluoride, the blood/urine calcium, the apoptosis in the hippocampus, and the expression levels of apoptosis-related genes, namely Bcl-2, caspase 12, and JNK. Blood or blood/urine fluoride levels and apoptotic cells were found significantly increased in fluorosis rat offspring as compared to controls. Furthermore, the Bcl-2 messenger RNA (mRNA) expression levels significantly decreased, and caspase 12 mRNA levels significantly increased in each age group as compared to controls. Compared with the fluoride group, the blood/urine fluoride content and apoptotic cells evidently decreased in the high calcium fluoride group, Bcl-2 mRNA expression significantly increased and caspase 12 mRNA expression significantly decreased in each age group. All results showed no gender difference. Based on these results, the molecular mechanisms of fluorosis-induced brain cell apoptosis in rat offspring may include the decrease in Bcl-2 mRNA expression level and increase in caspase 12 mRNA expression signaling pathways. High calcium intake could reverse these gene expression trends. By contrast, low calcium intake intensified the toxic effects of fluoride on brain cells.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Encéfalo/efeitos dos fármacos
Encéfalo/patologia
Cálcio/administração & dosagem
Cálcio/farmacologia
Intoxicação por Flúor/patologia
[Mh] Termos MeSH secundário: Administração Oral
Animais
Encéfalo/embriologia
Caspase 12/genética
Caspase 12/metabolismo
Feminino
Masculino
Proteínas Proto-Oncogênicas c-bcl-2/antagonistas & inibidores
Proteínas Proto-Oncogênicas c-bcl-2/genética
Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proto-Oncogene Proteins c-bcl-2); 0 (RNA, Messenger); EC 3.4.22.- (Caspase 12); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160923
[St] Status:MEDLINE
[do] DOI:10.1007/s12011-016-0850-9


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[PMID]:27702735
[Au] Autor:Zhou GY; Ren LJ; Hou JX; Cui LX; Ding Z; Cheng XM; Zhu JY; Cui RR; Ba Y
[Ad] Endereço:School of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
[Ti] Título:Endemic fluorosis in Henan province, China: ERα gene polymorphisms and reproductive hormones among women.
[So] Source:Asia Pac J Clin Nutr;25(4):911-919, 2016 Dec.
[Is] ISSN:0964-7058
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: The aim of this study was to explore the influence of fluoride exposure and ERα gene polymorphisms on reproductive hormone concentrations of women in accordance with endemic fluorosis residence. METHODS AND STUDY DESIGN: A cross sectional study was conducted in Tongxu county, Henan Province, China. A total of 679 women were recruited using cluster sampling and each subject provided fasting blood and an associated urine sample. We measured the concentrations of serum gonadotropin releasing hormone (GnRH), follicle-stimulating hormone, luteinizing hormone, and estradiol and urinary fluoride. RESULTS: In the defluoridation project group (DFPG), serum GnRH was lower in women carrying C/C genotype compared to in those carrying C/T and T/T genotypes of ERα gene rs3798577 (p<0.05). In the endemic fluorosis group (EFG), serum GnRH was lower in women carrying Pp genotype compared to in those carrying PP and pp genotypes of ERα PvuII (p<0.05). Serum GnRH in women from EFG who carried Pp, pp, Xx and xx genotypes in ERα gene PvuII and XbaI was lower than in those in the control group (CG) who carried same genotypes (p<0.05). Furthermore, serum GnRH in women from EFG was significantly lower than in those in CG, regardless of whether the women were carrying C/C, C/T or T/T genotypes of ERα rs3798577 (p<0.05). Serum estradiol concentrations in EFG were significantly lower than in CG when the women were carrying the Pp, Xx and T/T genotypes in ERα gene (p<0.05). CONCLUSION: Interaction of ERα gene and fluoride exposure may influence women's serum reproductive hormone concentrations.
[Mh] Termos MeSH primário: Doenças Endêmicas
Receptor alfa de Estrogênio/genética
Intoxicação por Flúor/epidemiologia
Intoxicação por Flúor/genética
Fluoretos/efeitos adversos
Hormônios/sangue
[Mh] Termos MeSH secundário: Adolescente
Adulto
China/epidemiologia
Estudos Transversais
Exposição Ambiental
Estradiol/sangue
Feminino
Fluoretos/urina
Fluorose Dentária
Hormônio Foliculoestimulante/sangue
Genótipo
Hormônio Liberador de Gonadotropina/sangue
Seres Humanos
Hormônio Luteinizante
Meia-Idade
Polimorfismo Genético
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estrogen Receptor alpha); 0 (Hormones); 0 (estrogen receptor alpha, human); 33515-09-2 (Gonadotropin-Releasing Hormone); 4TI98Z838E (Estradiol); 9002-67-9 (Luteinizing Hormone); 9002-68-0 (Follicle Stimulating Hormone); Q80VPU408O (Fluorides)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170119
[Lr] Data última revisão:
170119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161006
[St] Status:MEDLINE
[do] DOI:10.6133/apjcn.062016.01


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[PMID]:27472351
[Au] Autor:Kebede A; Retta N; Abuye C; Whiting SJ; Kassaw M; Zeru T; Tessema M; Kjellevold M
[Ad] Endereço:Food Science and Nutrition Research Directorate, Ethiopian Public Health Institute, P.O. Box 1242, Addis Ababa, Ethiopia. awekekeb@gmail.com.
[Ti] Título:Dietary Fluoride Intake and Associated Skeletal and Dental Fluorosis in School Age Children in Rural Ethiopian Rift Valley.
[So] Source:Int J Environ Res Public Health;13(8), 2016 Jul 26.
[Is] ISSN:1660-4601
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:An observational study was conducted to determine dietary fluoride intake, diet, and prevalence of dental and skeletal fluorosis of school age children in three fluorosis endemic districts of the Ethiopian Rift Valley having similar concentrations of fluoride (F) in drinking water (~5 mg F/L). The duplicate plate method was used to collect foods consumed by children over 24 h from 20 households in each community (n = 60) and the foods, along with water and beverages, were analyzed for fluoride (F) content. Prevalence of dental and skeletal fluorosis was determined using presence of clinical symptoms in children (n = 220). Daily dietary fluoride intake was at or above tolerable upper intake level (UL) of 10 mg F/day and the dietary sources (water, prepared food and beverages) all contributed to the daily fluoride burden. Urinary fluoride in children from Fentale and Adamitulu was almost twice (>5 mg/L) the concentration found in urine from children from Alaba, where rain water harvesting was most common. Severe and moderate dental fluorosis was found in Alaba and Adamitulu, the highest severity and prevalence being in the latter district where staple foods were lowest in calcium. Children in all three areas showed evidence of both skeletal and non-skeletal fluorosis. Our data support the hypothesis that intake of calcium rich foods in addition to using rain water for household consumption and preparation of food, may help in reducing risk of fluorosis in Ethiopia, but prospective studies are needed.
[Mh] Termos MeSH primário: Intoxicação por Flúor/epidemiologia
Intoxicação por Flúor/etiologia
Fluoretos/toxicidade
Fluorose Dentária/epidemiologia
Abastecimento de Água
Água/química
[Mh] Termos MeSH secundário: Doenças Ósseas/epidemiologia
Doenças Ósseas/etiologia
Cálcio/metabolismo
Criança
Dieta
Meio Ambiente
Etiópia/epidemiologia
Fluoretos/análise
Fluoretos/urina
Seres Humanos
Masculino
Prevalência
Estudos Prospectivos
População Rural
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water); Q80VPU408O (Fluorides); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160730
[St] Status:MEDLINE


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[PMID]:27414166
[Au] Autor:Mulay PR; Clark G; Jackson WL; Calvert GM
[Ti] Título:Notes from the Field: Acute Sulfuryl Fluoride Poisoning in a Family - Florida, August 2015.
[So] Source:MMWR Morb Mortal Wkly Rep;65(27):698-9, 2016 Jul 15.
[Is] ISSN:1545-861X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:On August 19, 2015, the Florida Department of Health (FDOH) was notified by the Florida Poison Information Center Network and a local hospital of possible sulfuryl fluoride poisonings affecting a family in Martin County, in southeastern Florida. Sulfuryl fluoride is a highly toxic (toxicity category I) gas fumigant used for termite control of homes and buildings.* FDOH personnel in Martin County commenced an investigation and identified a family of five (a grandmother, mother, father, son, and daughter) exposed to sulfuryl fluoride after their house was fumigated. The Florida Department of Agriculture and Consumer Services (FDACS), and the U.S. Environmental Protection Agency (EPA) Criminal Investigation Division also conducted an investigation after being notified by FDOH. Medical records were reviewed, and the father was interviewed by FDOH.
[Mh] Termos MeSH primário: Família
Intoxicação por Flúor/diagnóstico
Fumigação/efeitos adversos
Ácidos Sulfínicos/envenenamento
[Mh] Termos MeSH secundário: Adulto
Idoso
Criança
Feminino
Florida
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfinic Acids); 64B59K7U6Q (sulfuryl fluoride)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160715
[St] Status:MEDLINE
[do] DOI:10.15585/mmwr.mm6527a4


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[PMID]:26998958
[Au] Autor:Srisuma S; Cao D; Kleinschmidt K; Heffner AC; Lavonas EJ
[Ad] Endereço:a Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority , Denver , CO , USA ;
[Ti] Título:Missed opportunities?: an evaluation of potentially preventable poisoning deaths.
[So] Source:Clin Toxicol (Phila);54(5):441-6, 2016 Jun.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Although most poisoning deaths are not preventable with current medical technology, in some cases different management decisions may have prevented fatal outcomes. OBJECTIVE: This study aims to review reported poisoning-related deaths for preventability to provide insight to improve future care. METHODS: Fatality abstracts published in the US National Poison Data System (NPDS) Annual Reports (2008-2012) were analyzed. Preventability was graded using a Likert scale of 1 (definitely non-preventable) to 6 (definitely preventable). Two medical toxicologists screened all cases. Cases deemed definitely not preventable (score 1) by both reviewers were excluded from further review and considered to be "non-preventable". All cases considered at least possibly preventable by either screener were reviewed by a multidisciplinary panel of 5 physicians for preventability scoring. Differences were resolved by consensus. Cases determined to be "preventable" (scores 4-6) were characterized by type of improvement issue involved (diagnosis, treatment, monitoring, other) and recurring scenarios. RESULTS: Of 390 published abstracts, 78 (20.0%) deaths were considered at least possibly preventable by at least one screener. Of these, 34 (8.7%) deaths were determined to be "preventable" by the panel. Inter-observer agreement by weighted kappa analysis was 0.58 for screening, 0.24 for preventability, and 0.44 for specific aspects of care. The most common toxicants were salicylates (n = 9), opioids (n = 4), toxic alcohols (n = 3), fluoride containing product (n = 3), and bupropion (n = 3). The most common improvement opportunities involved treatment and monitoring. DISCUSSION: Most of the ingested substances in preventable deaths have delayed GI absorption or require metabolic activation to produce a delayed effect (such as salicylates, opioids, and toxic alcohols), and therefore provide an opportunity for early recognition and successful interventions. Most improvement opportunities are clearly described in the literature but may be not recognized. CONCLUSIONS: Based on an analysis of published NPDS data, a considerable number of poisoning-related deaths reaching medical attention may be preventable. The most common scenarios involved in potentially preventable poisoning fatalities related to monitoring and treatment. Salicylates and opioids were the most common agents involved in preventable deaths.
[Mh] Termos MeSH primário: Centros de Controle de Intoxicações
Envenenamento/mortalidade
Envenenamento/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Analgésicos Opioides/envenenamento
Bupropiona/envenenamento
Bases de Dados Factuais
Feminino
Intoxicação por Flúor/mortalidade
Intoxicação por Flúor/prevenção & controle
Seres Humanos
Sistemas de Informação
Masculino
Meia-Idade
Variações Dependentes do Observador
Salicilatos/envenenamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Salicylates); 01ZG3TPX31 (Bupropion)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160322
[St] Status:MEDLINE
[do] DOI:10.3109/15563650.2016.1157721


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[PMID]:26606914
[Au] Autor:Li M; Gao Y; Cui J; Li Y; Li B; Liu Y; Sun J; Liu X; Liu H; Zhao L; Sun D
[Ad] Endereço:Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), China and Russia Medical Research Center, Harbin Medical University, 157 Baojian Road, Harbin, 1
[Ti] Título:Cognitive Impairment and Risk Factors in Elderly People Living in Fluorosis Areas in China.
[So] Source:Biol Trace Elem Res;172(1):53-60, 2016 Jul.
[Is] ISSN:1559-0720
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Residents living in fluorosis areas generally experienced long-term exposure to excessive fluoride in drinking water. The adverse effects of high fluoride levels on the nervous system have been studied; however, the effect of fluoride exposure on cognitive functions of elderly people in fluorosis areas is rarely reported. This study was aimed to find out the potential risk factors of cognitive impairment among elderly people who lived in fluorosis areas of China. A total of 511 subjects, aged 60 years or above, were investigated in fluorosis areas of Heilongjiang Province, Inner Mongolia Autonomous Region, Qinghai Province, and Xinjiang Uygur Autonomous Region. The Mini-Mental State Examination (MMSE) was used to examine cognitive functions of the study subjects. Based on the MMSE scores, the study subjects were divided into normal group and cognitive impairment group that consisted of mild, moderate, and severe groups. Multivariable logistic regression showed that a higher risk of cognitive impairment was associated with increased age and decreased education levels. Multiple linear regression analysis revealed that MMSE scores were negatively associated with serum homocysteine (Hcy) levels. However, both urinary fluoride and serum Hcy levels in the normal group were not the lowest among the four groups. Spearman's correlation analysis showed that urinary fluoride levels were positively correlated with serum Hcy (r s = 0.209, P < 0.01). Our study suggests that people with cognitive impairment in fluorosis areas have elevated serum Hcy levels, which was positively correlated with urinary fluoride concentrations. A certain low dose of fluoride intake may play a potential protective rather than harmful role in cognitive functions; however, high fluoride exposure is a potential risk factor for cognitive impairment.
[Mh] Termos MeSH primário: Disfunção Cognitiva/sangue
Intoxicação por Flúor/sangue
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
China
Água Potável/análise
Feminino
Fluoretos/administração & dosagem
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drinking Water); Q80VPU408O (Fluorides)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170203
[Lr] Data última revisão:
170203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151127
[St] Status:MEDLINE
[do] DOI:10.1007/s12011-015-0568-0



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