Base de dados : MEDLINE
Pesquisa : C25.723.415 [Categoria DeCS]
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  1 / 8106 MEDLINE  
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[PMID]:29446266
[Au] Autor:Klepikov OV; Khatuaev RO; Istomin AV; Rumyantseva LA
[Ti] Título:[Regional features of food standards and health risks associated with chemical contamination of food].
[So] Source:Gig Sanit;95(11):1086-91, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:In the article there are presented results of a study of the balance of food consumption by the population of the Voronezh region, the assessment of the level of contamination of food products and both carcinogenic and non-carcinogenic and public health risk caused by this contamination. There was evaluated the level of nutrition-dependent diseases. A special feature of this study is a comparative analysis of data obtained during the two five-year periods of 1995-1999 and 2010-2014, that permitted to reveal changes in food consumption, the dynamics of morbidity rate associated with the nutritional factor.
[Mh] Termos MeSH primário: Análise de Alimentos
Contaminação de Alimentos
Qualidade dos Alimentos
Doenças Transmitidas por Alimentos/prevenção & controle
[Mh] Termos MeSH secundário: Exposição Dietética/efeitos adversos
Exposição Dietética/análise
Exposição Dietética/prevenção & controle
Análise de Alimentos/métodos
Análise de Alimentos/normas
Análise de Alimentos/estatística & dados numéricos
Contaminação de Alimentos/análise
Contaminação de Alimentos/prevenção & controle
Contaminação de Alimentos/estatística & dados numéricos
Doenças Transmitidas por Alimentos/epidemiologia
Doenças Transmitidas por Alimentos/etiologia
Seres Humanos
Controle de Qualidade
Medição de Risco/estatística & dados numéricos
Federação Russa/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE


  2 / 8106 MEDLINE  
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[PMID]:29446265
[Au] Autor:Popova AY; Trukhina GM; Mikailova OM
[Ti] Título:[Introduction of hazard analysis and critical control points (HACCP) principles at the flight catering food production plant].
[So] Source:Gig Sanit;95(11):1083-6, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:In the article there is considered the quality control and safety system implemented in the one of the largest flight catering food production plant for airline passengers and flying squad. The system for the control was based on the Hazard Analysis And Critical Control Points (HACCP) principles and developed hygienic and antiepidemic measures. There is considered the identification of hazard factors at stages of the technical process. There are presented results of the analysis data of monitoring for 6 critical control points over the five-year period. The quality control and safety system permit to decline food contamination risk during acceptance, preparation and supplying of in-flight meal. There was proved the efficiency of the implemented system. There are determined further ways of harmonization and implementation for HACCP principles in the plant.
[Mh] Termos MeSH primário: Aviação
Análise de Alimentos
Contaminação de Alimentos/prevenção & controle
Manipulação de Alimentos
Doenças Transmitidas por Alimentos/prevenção & controle
Análise de Perigos e Pontos Críticos de Controle/métodos
[Mh] Termos MeSH secundário: Aviação/organização & administração
Aviação/normas
Exposição Dietética/efeitos adversos
Exposição Dietética/análise
Exposição Dietética/prevenção & controle
Análise de Alimentos/métodos
Análise de Alimentos/normas
Análise de Alimentos/estatística & dados numéricos
Manipulação de Alimentos/métodos
Manipulação de Alimentos/normas
Qualidade dos Alimentos
Doenças Transmitidas por Alimentos/epidemiologia
Doenças Transmitidas por Alimentos/etiologia
Seres Humanos
Controle de Qualidade
Federação Russa/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE


  3 / 8106 MEDLINE  
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[PMID]:29431324
[Au] Autor:Fedorenko EV; Kolomiets ND; Sychik SI
[Ti] Título:[Actual problems of the microbiological safety of food products].
[So] Source:Gig Sanit;95(9):873-8, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Food-borne infectious diseases remain an actual problem of health care. In the Republic of Belarus the level of food-borne diseases persists to be stable, at the same time these diseases remain to be significant. Despite the insignificant number of nonconforming food samples the prevalence rates of food-borne acute infectious diseases of various etiology with dominantly food transmission pathway remain to be rather high. The mentioned fact determines the need for the development of approaches on the security of microbiological food safety based on the risk analysis. There are determined criteria for a hygienic assessment of the microbiological hazards (associated with the pathogen, food products and a consumer health state), there is presented the classification offood products in dependence on the grade of microbiological risk. There was performed the comparative analysis of requirements for the microbiological safety of food accepted in the Republic of Belarus and European Economic Union, in the European Union and at the international level, which testify to the presence of separate differences. Based on the international approaches there was substantiated the multilevel control system of management of microbiological risks, there is reported the characteristic of separate criteria. There are determined the directions of the improvement of the security of microbiological safety of food.
[Mh] Termos MeSH primário: Contaminação de Alimentos
Manipulação de Alimentos
Microbiologia de Alimentos
Doenças Transmitidas por Alimentos
[Mh] Termos MeSH secundário: Contaminação de Alimentos/análise
Contaminação de Alimentos/prevenção & controle
Manipulação de Alimentos/métodos
Manipulação de Alimentos/normas
Microbiologia de Alimentos/métodos
Microbiologia de Alimentos/normas
Qualidade dos Alimentos
Doenças Transmitidas por Alimentos/epidemiologia
Doenças Transmitidas por Alimentos/microbiologia
Doenças Transmitidas por Alimentos/prevenção & controle
Seres Humanos
Saúde Pública/métodos
Saúde Pública/normas
República da Bielorrússia/epidemiologia
Medição de Risco/métodos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


  4 / 8106 MEDLINE  
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[PMID]:29341609
[Au] Autor:Liu JM; Wang ZH; Ma H; Wang S
[Ad] Endereço:Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University , 94 Weijin Road, Tianjin 300071, People's Republic of China.
[Ti] Título:Probing and Quantifying the Food-Borne Pathogens and Toxins: From In Vitro to In Vivo.
[So] Source:J Agric Food Chem;66(5):1061-1066, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Development of real-time and in situ analytical methods for determination of food-borne pathogens and toxins ingested into the human body would be a promising research direction in the food-safety area. The present perspective starts with summarization of the up-to-date progress of the nanomaterial-assisted in vitro detection methods for pathogens and toxins and finally focuses on application of animal bioimaging to in vivo study, including prospective strategies for in vivo quantification of target pathogens or toxins and in vivo investigation of their behaviors inside the living body, with the assistance of real-time and non-invasive optical bioimaging. This perspective provides the advisory direction for food-safety research, from in vitro to in vivo, along with a prospective discussion of the further development roadmap of the food-safety detection techniques, especially the bioimaging-guided methods for investigation and mediation of the food contamination effect to human health.
[Mh] Termos MeSH primário: Contaminação de Alimentos/análise
Inocuidade dos Alimentos/métodos
Toxinas Biológicas/análise
[Mh] Termos MeSH secundário: Animais
Diagnóstico por Imagem/métodos
Microbiologia de Alimentos/métodos
Doenças Transmitidas por Alimentos/microbiologia
Doenças Transmitidas por Alimentos/prevenção & controle
Seres Humanos
Nanoestruturas
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Toxins, Biological)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05225


  5 / 8106 MEDLINE  
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[PMID]:29080423
[Au] Autor:Cha W; Fratamico PM; Ruth LE; Bowman AS; Nolting JM; Manning SD; Funk JA
[Ad] Endereço:Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.
[Ti] Título:Prevalence and characteristics of Shiga toxin-producing Escherichia coli in finishing pigs: Implications on public health.
[So] Source:Int J Food Microbiol;264:8-15, 2018 Jan 02.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Shiga toxin-producing Escherichia coli (STEC) are important food-borne pathogens, which can cause serious illnesses, including hemorrhagic colitis and hemolytic uremic syndrome. To study the epidemiology of STEC in finishing pigs and examine the potential risks they pose for human STEC infections, we conducted a longitudinal cohort study in three finishing sites. Six cohorts of pigs (2 cohorts/site, 20 pigs/cohort) were randomly selected, and fecal samples (n=898) were collected every two weeks through their finishing period. Eighty-two pigs (68.3%) shed STEC at least once, and the proportion of STEC-positive pigs varied across sites (50-97.5%) and cohorts (15-100%). Clinically important serotypes, O157:H7 (stx , eae) and O26:H11 (stx , eae), were recovered from two pigs at sites C and A, respectively. The most common serotype isolated was O59:H21 (stx ), which was particularly prevalent in site B as it was recovered from all STEC positive pigs (n=39). Each cohort showed different patterns of STEC shedding, which were associated with the prevalent serotype. The median shedding duration of STEC in pigs was 28days, consistent with our prior study. However, among pigs shedding O59:H21 at least once, pigs in cohort B2 had a significantly longer shedding duration of 42days (P<0.05) compared to other cohorts. Stx2e was the most commonly observed stx variant in finishing pigs (93.9%), in accordance with the previous studies. Stx2e has been reported to be significantly associated with edema disease in pigs, however, the pathogenicity in humans warrants further investigations. Nonetheless, our findings affirm that pigs are an important reservoir for human STEC infections, and that the circulating serotypes in a cohort and site management factors may significantly affect the prevalence of STEC. Molecular characterization of STEC isolates and epidemiological studies to identify risk factors for shedding in pigs are strongly warranted to further address the significance to public health and to develop mitigation strategies.
[Mh] Termos MeSH primário: Adesinas Bacterianas/genética
Proteínas de Escherichia coli/genética
Doenças Transmitidas por Alimentos/microbiologia
Escherichia coli Shiga Toxigênica/classificação
Escherichia coli Shiga Toxigênica/genética
Sus scrofa/microbiologia
[Mh] Termos MeSH secundário: Animais
Infecções por Escherichia coli
Fezes/microbiologia
Seres Humanos
Estudos Longitudinais
Prevalência
Saúde Pública
Sorogrupo
Escherichia coli Shiga Toxigênica/isolamento & purificação
Escherichia coli Shiga Toxigênica/patogenicidade
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adhesins, Bacterial); 0 (Escherichia coli Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171029
[St] Status:MEDLINE


  6 / 8106 MEDLINE  
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[PMID]:29420460
[Au] Autor:Burakoff A; Brown K; Knutsen J; Hopewell C; Rowe S; Bennett C; Cronquist A
[Ti] Título:Outbreak of Fluoroquinolone-Resistant Campylobacter jejuni Infections Associated with Raw Milk Consumption from a Herdshare Dairy - Colorado, 2016.
[So] Source:MMWR Morb Mortal Wkly Rep;67(5):146-148, 2018 Feb 09.
[Is] ISSN:1545-861X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In August 2016, a local public health agency (LPHA) notified the Colorado Department of Public Health and Environment (CDPHE) of two culture-confirmed cases of Campylobacter infection among persons who consumed raw (unpasteurized) milk from the same herdshare dairy. In Colorado, the sale of raw milk is illegal; however, herdshare programs, in which a member can purchase a share of a herd of cows or goats, are legal and are not regulated by state or local authorities. In coordination with LPHAs, CDPHE conducted an outbreak investigation that identified 12 confirmed and five probable cases of Campylobacter jejuni infection. Pulsed-field gel electrophoresis (PFGE) patterns for the 10 cases with available isolates were identical using the enzyme Sma. In addition, two milk samples (one from the dairy and one obtained from an ill shareholder) also tested positive for the outbreak strain. Five C. jejuni isolates sent to CDC for antimicrobial susceptibility testing were resistant to ciprofloxacin, tetracycline, and nalidixic acid (1). Although shareholders were notified of the outbreak and cautioned against drinking the milk on multiple occasions, milk distribution was not discontinued. Although its distribution is legal through herdshare programs, drinking raw milk is inherently risky (2). The role of public health in implementing control measures associated with a product that is known to be unsafe remains undefined.
[Mh] Termos MeSH primário: Infecções por Campylobacter/epidemiologia
Campylobacter jejuni/efeitos dos fármacos
Surtos de Doenças
Fluoroquinolonas/farmacologia
Microbiologia de Alimentos
Doenças Transmitidas por Alimentos/epidemiologia
Leite/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Animais
Infecções por Campylobacter/tratamento farmacológico
Criança
Colorado/epidemiologia
Farmacorresistência Bacteriana
Feminino
Doenças Transmitidas por Alimentos/tratamento farmacológico
Seres Humanos
Masculino
Meia-Idade
Alimentos Crus
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluoroquinolones)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.15585/mmwr.mm6705a2


  7 / 8106 MEDLINE  
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[PMID]:29377696
[Au] Autor:Efimochkina NR
[Ti] Título:[Evaluation of the role of Campylobacter spp. in the occurrence of foodborne diseases and modern methods to detect the pathogen].
[So] Source:Vopr Pitan;84(6):5-18, 2015.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Infections caused by Campylobacter spp. are now considered to be one of the most important foodborne diseases worldwide, this organism is one of the most epidemiologically significant zoonotic pathogens. Among these pathogens Campylobacter jejuni have the greatest epidemiological importance, they are responsible for 90% of laboratory confirmed cases of food campylobacteriosis. The frequency of detection of campylobacters in the environmental and on many raw foods, of both plant and animal origin, in normal intestine biota of domestic and wild animal and birds, indicates the prevalence of these bacteria and the high risk of contamination of food and water. The main factors of transmission in sporadic campylobacteriosis are the poultry and poultry products (up to 70% of the total number of cases), water (8%), raw milk (5%). One of the risk factors for the spread of emergent pathogen is its ability to persist in aquatic ecosystems. Continuing changes in landscape and agricultural intensification can cause further enhance microbial contamination of freshwater bodies and groundwater, and the associated increase in the number of cases of waterborne campylobacteriosis. Intensification of agriculture, expanding the range of applied disinfectants and antiseptics, uncontrolled use of antibiotics in livestock often leads to the selection of the sustainable strains of Campylobacter spp., which have antibiotic resistance and multiple virulence determinants. This paper presents an overview of modern methods for the detection of Campylobacter spp., detailed culture and biochemical methods for the isolation of C. jejuni based on the use of selective culture media and diagnostic kits for the characterization of the phenotypic profiles of the strains. These methods are the starting point in selecting the most effective schemes of food control and surveillance. It is emphasized that the basis of microbiological analysis should be molecular methods based on real-time PCR, which allows to quantify present in foods of thermotolerant Campylobacter, including C. jejuni.
[Mh] Termos MeSH primário: Infecções por Campylobacter
Campylobacter
Contaminação de Alimentos/prevenção & controle
Microbiologia de Alimentos
Doenças Transmitidas por Alimentos
[Mh] Termos MeSH secundário: Animais
Infecções por Campylobacter/epidemiologia
Infecções por Campylobacter/prevenção & controle
Doenças Transmitidas por Alimentos/epidemiologia
Doenças Transmitidas por Alimentos/prevenção & controle
Seres Humanos
Carne/microbiologia
Aves Domésticas/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE


  8 / 8106 MEDLINE  
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[PMID]:28452235
[Au] Autor:Mizan MFR; Bang HJ; Sadekuzzaman M; Lee N; Kim TJ; Ha SD
[Ad] Endereço:a Department of Food Science and Technology, Advanced Food Safety Research group, Brain Korea 21 Plus , Chung-Ang University , Anseong , Republic of Korea.
[Ti] Título:Molecular characteristics, biofilm-forming abilities, and quorum sensing molecules in Vibrio parahaemolyticus strains isolated from marine and clinical environments in Korea.
[So] Source:Biofouling;33(5):369-378, 2017 05.
[Is] ISSN:1029-2454
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Vibrio parahaemolyticus is an inhabitant of marine and estuarine environments and causes seafood-borne gastroenteritis in humans. In this study, an UltraFast LabChip Real-Time PCR assay was evaluated for rapid detection and quantification of pathogenic V. parahaemolyticus isolates. Escherichia coli and Vibrio harveyi were used as negative controls. Twenty-six tdh-positive, biofilm-producing V. parahaemolyticus isolates were analyzed by repetitive extragenic palindromic-polymerase chain reaction (REP-PCR). REP-PCR analysis showed that the majority of the V. parahaemolyticus isolates originated from seafood and that clinical specimens formed two major clusters at 92.8% and 32% similarity levels. The presence and quantification of Autoinducer-2 was carried out using high-performance liquid chromatography with fluorescence detection (HPLC-FLD) after derivatization of Autoinducer-2 with 2, 3-diaminonaphthalene. The presence of tdh-positive V. parahaemolyticus in marine samples highlights the need for constant environmental monitoring to protect public health.
[Mh] Termos MeSH primário: Biofilmes/crescimento & desenvolvimento
Técnicas de Laboratório Clínico/métodos
Microbiologia Ambiental
Percepção de Quorum
Alimentos Marinhos/microbiologia
Vibrio parahaemolyticus/isolamento & purificação
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão/métodos
Microbiologia Ambiental/normas
Microbiologia de Alimentos/métodos
Doenças Transmitidas por Alimentos/microbiologia
Doenças Transmitidas por Alimentos/prevenção & controle
Seres Humanos
Reação em Cadeia da Polimerase em Tempo Real/métodos
República da Coreia
Sensibilidade e Especificidade
Especificidade da Espécie
Vibrio parahaemolyticus/genética
Vibrio parahaemolyticus/patogenicidade
Vibrio parahaemolyticus/fisiologia
Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1080/08927014.2017.1316840


  9 / 8106 MEDLINE  
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[PMID]:29311445
[Au] Autor:Somura Y; Kimoto K; Oda M; Okutsu Y; Kato R; Suzuki Y; Siki D; Hirai A; Akiba T; Shinkai T; Sadamasu K
[Ad] Endereço:Tokyo Metropolitan Institute of Public Health.
[Ti] Título:[Serial Food Poisoning Outbreaks Caused by Norovirus-Contaminated Shredded Dried Laver Seaweed Provided at School Lunch, Tokyo, 2017].
[So] Source:Shokuhin Eiseigaku Zasshi;58(6):260-267, 2017.
[Is] ISSN:1882-1006
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:In February 2017, four food poisoning outbreaks occurred in Tokyo, involving ten schools. Shredded dried laver seaweed processed by a single food manufacturer in December 2016 was provided in common for the school meals that caused all four outbreaks. Of 4,209 persons exposed, 1,193 (28.3%) had symptoms of gastroenteritis. Norovirus (NoV) GII was detected in 207 (78.1%) of 265 cases by real-time RT-PCR. Thirty-one shredded dried laver seaweed samples were examined and seven (22.6%) of them were positive for NoV GII. PCR fragments of NoV ORF1/2 junction region (302 bp) from seven shredded dried laver seaweed samples and 20 clinical samples derived from the four outbreaks were sequenced. All of them displayed complete homology, and the genotype was classified as GII.17. A nearly full-length sequence (7,420 bp) of NoV RNA derived from a case was obtained by next-generation sequencer analysis and phylogenetic analysis indicated that this strain belongs to the same cluster as Hu/GII/JP/2015/GII.P17_GII.17/Kawasaki308. Thus, our investigation elucidated that the causative agent of these four serial food poisoning outbreaks was NoV GII.17 and the infectious source was a single batch of shredded dried laver seaweed. The water activity of the shredded dried laver seaweed was found to be 0.119 to 0.129. It was epidemiologically clarified that NoV does not lose infectivity for about two months even in the dry state. We conclude that a large diffuse outbreak of food poisoning caused by NoV GII.17 contamination of shredded dried laver seaweed had occurred in Tokyo. Our elucidation of the causative agent indicated that the food poisoning outbreaks in multiple areas of Japan, including Tokyo, during January to February 2017 were caused by the same contaminated food.
[Mh] Termos MeSH primário: Infecções por Caliciviridae/etiologia
Infecções por Caliciviridae/virologia
Surtos de Doenças/estatística & dados numéricos
Análise de Alimentos
Contaminação de Alimentos/análise
Doenças Transmitidas por Alimentos/etiologia
Doenças Transmitidas por Alimentos/virologia
Almoço
Norovirus/isolamento & purificação
Instituições Acadêmicas/estatística & dados numéricos
Alga Marinha/virologia
[Mh] Termos MeSH secundário: Infecções por Caliciviridae/epidemiologia
Cobicistat
Combinação de Medicamentos
Emtricitabina
Doenças Transmitidas por Alimentos/epidemiologia
Norovirus/classificação
Norovirus/genética
Quinolonas
RNA Viral/isolamento & purificação
Tenofovir/análogos & derivados
Fatores de Tempo
Tóquio/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Quinolones); 0 (RNA, Viral); 0 (genovoya); 99YXE507IL (Tenofovir); G70B4ETF4S (Emtricitabine); LW2E03M5PG (Cobicistat)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.3358/shokueishi.58.260


  10 / 8106 MEDLINE  
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[PMID]:29311444
[Au] Autor:Tsujimura K; Yoshimura H; Taguri T; Motomura H
[Ad] Endereço:Nagasaki Prefectural Institute of Environment and Public Health.
[Ti] Título:[Tetrodotoxin (TTX) Monitoring of Biological Specimens and Toxin Profile in a Food Poisoning Case Caused by the Scavenging Gastropod Nassarius (Alectrion) glans "Kinshibai"].
[So] Source:Shokuhin Eiseigaku Zasshi;58(6):253-259, 2017.
[Is] ISSN:1882-1006
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:In November 2015, a patient presented with symptoms of toxicity after eating whole boiled samples of the scavenging gastropod Nassarius (Alectrion) glans "Kinshibai" in Nagasaki. This food poisoning case was the third recorded in Japan. The case was investigated by evaluation of the toxin profile of the gastropod, and monitoring of tetrodotoxin (TTX) levels in serum and urine sampled from the affected individual. One gastropod contained a harmful dose of TTX (2.5 mg/ individual in food residue sample 2). In biological samples, maximum TTX concentrations were 42.8 ng/mL in serum on the day after onset of symptoms. TTX urinary excretion was calculated to be 2.4 mg. From the measured TTX concentrations, it was estimated that a lethal dose had been ingested in this case. Moreover, it was found by LC-QqQ-MS/MS analysis and mouse bioassay that the toxicity of "Kinshibai" was not solely due to TTX. The remaining toxicity was thought to be due to 11-oxoTTX. As in previous poisoning cases, it was concluded that ingestion of this gastropod poses a high risk of food poisoning.
[Mh] Termos MeSH primário: Doenças Transmitidas por Alimentos/diagnóstico
Doenças Transmitidas por Alimentos/etiologia
Gastrópodes
Tetrodotoxina/sangue
Tetrodotoxina/urina
[Mh] Termos MeSH secundário: Idoso
Animais
Bioensaio/métodos
Biomarcadores/sangue
Biomarcadores/urina
Cromatografia Líquida/métodos
Análise de Alimentos/métodos
Gastrópodes/química
Seres Humanos
Japão
Masculino
Camundongos
Monitorização Fisiológica/métodos
Risco
Espectrometria de Massas em Tandem/métodos
Tetrodotoxina/análise
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 4368-28-9 (Tetrodotoxin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.3358/shokueishi.58.253



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