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[PMID]:28535116
[Au] Autor:Mullins ME; Hoffman RS
[Ad] Endereço:a Division of Emergency Medicine , Washington University School of Medicine , Saint Louis , MO , USA.
[Ti] Título:Is mannitol the treatment of choice for patients with ciguatera fish poisoning?
[So] Source:Clin Toxicol (Phila);55(9):947-955, 2017 Nov.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Ciguatera fish poisoning arises primarily from consumption of carnivorous reef fish caught in tropical and sub-tropical waters. Ciguatoxins, a class of tasteless, heat-stable, polycyclic toxins produced by dinoflagellates, accumulate through the food chain and concentrate in various carnivorous fish, such as groupers, barracudas, wrasses, amberjack, kingfishes, and eels. Characteristics of ciguatera fish poisoning include early nausea, vomiting, and diarrhea in the first one to two days post ingestion, followed by the appearance of sensory disturbances. The classic dysaesthesia is cold allodynia, often described as reversal of hot and cold sensation, but a more accurate description is burning pain on exposure to cold. OBJECTIVE: To discuss and appraise the evidence regarding the use of mannitol or other drugs in treating ciguatera framed in the historical context of the last four decades. METHODS: We searched PubMed and Embase for all years from 1966 to March 31, 2017 with search terms "ciguatera", "mannitol", and "treatment". These searches identified 85 articles, of which 36 were relevant to the review question. We searched Google Scholar to supplement the primary search and reviewed the references of articles for sources overlooked in the original searches. These secondary searches identified another 23 references. We excluded six clinical reports (two case series and four case reports) which did not clearly describe ciguatera or which lacked information on treatment or outcome. Fifty-three clinical articles remained for review. We searched PubMed using "ciguatera" AND "treatment" NOT "mannitol" to better identify reports describing other treatments. The search identified 128 articles, of which nine described specific pharmacological treatments and their outcomes. We combined our findings into a consensus review of the evidence both for and against the use of mannitol or other medications for ciguatera fish poisoning. Early human evidence of effectiveness of mannitol: A 1988 report described an unexpected discovery that intravenous mannitol could rapidly and effectively treat ciguatera fish poisoning. Several other uncontrolled case series and case reports appeared to support the use of mannitol. In 2002, a small randomized, controlled trial reported no significant difference between mannitol and normal saline. Subsequent case reports have cited this study as the reason for or to withhold mannitol. Thus, some controversy exists regarding whether mannitol is useful or not for treating ciguatera fish poisoning. Basic science and animal research on ciguatera and mannitol: In vitro experiments of isolated neurons demonstrate that ciguatoxins produce neuronal edema, open certain sodium channels, block potassium channels, cause uncontrolled and repetitive action potentials after a stimulus. Addition of mannitol decreases the edema and reduces the uncommanded action potentials. However, intraperitoneal injection of ciguatoxin in rats increases neuronal refractory period and slows nerve conduction velocity. Treatment with mannitol fails to correct these effects. Comparative trials of mannitol: Evidence supporting mannitol for ciguatera fish poisoning includes four uncontrolled case series, one prospective, unblinded comparative trial and several case reports. Evidence against mannitol consists of one RCT, which has a small sample size and several potential limitations. Empirical human experience with other treatments: Evidence regarding other treatments consists only of ten case reports and three overlapping case series that describe using amitriptyline, fluoxetine, duloxetine, gabapentin, pregabalin, or tocainide. For each of these, a long duration of treatment appears to be necessary to maintain symptomatic improvement. None of these treatments has been shown to be superior to mannitol. CONCLUSIONS: It is reasonable to consider using intravenous mannitol in cases of acute ciguatera fish poisoning. Medications used in other neuropathic syndromes appear to suppress the paresthesiae of persistent ciguatera cases. However, the human evidence is of low quality for all treatments.
[Mh] Termos MeSH primário: Intoxicação por Ciguatera/tratamento farmacológico
Manitol/administração & dosagem
Parestesia/tratamento farmacológico
Alimentos Marinhos/parasitologia
[Mh] Termos MeSH secundário: Administração Intravenosa
Animais
Intoxicação por Ciguatera/parasitologia
Intoxicação por Ciguatera/fisiopatologia
Seres Humanos
Manitol/efeitos adversos
Parestesia/parasitologia
Parestesia/fisiopatologia
Alimentos Marinhos/efeitos adversos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
3OWL53L36A (Mannitol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.1080/15563650.2017.1327664


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[PMID]:28437641
[Au] Autor:Coccini T; Caloni F; De Simone U
[Ad] Endereço:Laboratory of Clinical and Experimental Toxicology, Poison Control Centre, Toxicology Unit, Maugeri Clinical Scientific Institutes S.p.A.-BS, IRCCS Pavia, Pavia Italy. Electronic address: teresa.coccini@icsmaugeri.it.
[Ti] Título:Human neuronal cell based assay: A new in vitro model for toxicity evaluation of ciguatoxin.
[So] Source:Environ Toxicol Pharmacol;52:200-213, 2017 Jun.
[Is] ISSN:1872-7077
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Ciguatoxins (CTXs) are emerging marine neurotoxins representing the main cause of ciguatera fish poisoning, an intoxication syndrome which configures a health emergency and constitutes an evolving issue constantly changing due to new vectors and derivatives of CTXs, as well as their presence in new non-endemic areas. The study applied the neuroblastoma cell model of human origin (SH-SY5Y) to evaluate species-specific mechanistic information on CTX toxicity. Metabolic functionality, cell morphology, cytosolic Ca responses, neuronal cell growth and proliferation were assessed after short- (4-24h) and long-term exposure (10days) to P-CTX-3C. In SH-SY5Y, P-CTX-3C displayed a powerful cytotoxicity requiring the presence of both Veratridine and Ouabain. SH-SY5Y were very sensitive to Ouabain: 10 and 0.25nM appeared the optimal concentrations, for short- and long-term toxicity studies, respectively, to be used in co-incubation with Veratridine (25µM), simulating the physiological and pathological endogenous Ouabain levels in humans. P-CTX-3C cytotoxic effect, on human neurons co-incubated with OV (Ouabain+Veratridine) mix, was expressed starting from 100pM after short- and 25pM after long-term exposure. Notably, P-CTX-3C alone at 25nM induced cytotoxicity after 24h and prolonged exposure. This human brain-derived cell line appears a suitable cell-based-model to evaluate cytotoxicity of CTX present in marine food contaminated at low toxic levels and to characterize the toxicological profile of other/new congeners.
[Mh] Termos MeSH primário: Ciguatoxinas/toxicidade
Contaminação de Alimentos
Neurônios/efeitos dos fármacos
[Mh] Termos MeSH secundário: Cálcio/metabolismo
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Intoxicação por Ciguatera/prevenção & controle
Seres Humanos
Neurônios/metabolismo
Neurônios/fisiologia
Ouabaína/toxicidade
Veratridina/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
11050-21-8 (Ciguatoxins); 5ACL011P69 (Ouabain); 71-62-5 (Veratridine); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE


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[PMID]:28335428
[Au] Autor:Friedman MA; Fernandez M; Backer LC; Dickey RW; Bernstein J; Schrank K; Kibler S; Stephan W; Gribble MO; Bienfang P; Bowen RE; Degrasse S; Flores Quintana HA; Loeffler CR; Weisman R; Blythe D; Berdalet E; Ayyar R; Clarkson-Townsend D; Swajian K; Benner R; Brewer T; Fleming LE
[Ad] Endereço:Mount Sinai Medical Center, Miami Beach, FL 33140, USA. melissafried@yahoo.com.
[Ti] Título:An Updated Review of Ciguatera Fish Poisoning: Clinical, Epidemiological, Environmental, and Public Health Management.
[So] Source:Mar Drugs;15(3), 2017 Mar 14.
[Is] ISSN:1660-3397
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Ciguatera Fish Poisoning (CFP) is the most frequently reported seafood-toxin illness in the world. It causes substantial human health, social, and economic impacts. The illness produces a complex array of gastrointestinal, neurological and neuropsychological, and cardiovascular symptoms, which may last days, weeks, or months. This paper is a general review of CFP including the human health effects of exposure to ciguatoxins (CTXs), diagnosis, human pathophysiology of CFP, treatment, detection of CTXs in fish, epidemiology of the illness, global dimensions, prevention, future directions, and recommendations for clinicians and patients. It updates and expands upon the previous review of CFP published by Friedman et al. (2008) and addresses new insights and relevant emerging global themes such as climate and environmental change, international market issues, and socioeconomic impacts of CFP. It also provides a proposed universal case definition for CFP designed to account for the variability in symptom presentation across different geographic regions. Information that is important but unchanged since the previous review has been reiterated. This article is intended for a broad audience, including resource and fishery managers, commercial and recreational fishers, public health officials, medical professionals, and other interested parties.
[Mh] Termos MeSH primário: Intoxicação por Ciguatera/epidemiologia
Ciguatoxinas/toxicidade
Peixes/metabolismo
Alimentos Marinhos/envenenamento
[Mh] Termos MeSH secundário: Animais
Surtos de Doenças
Seres Humanos
Saúde Pública
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
11050-21-8 (Ciguatoxins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE


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[PMID]:27885668
[Au] Autor:Kretzschmar AL; Verma A; Harwood T; Hoppenrath M; Murray S
[Ad] Endereço:Climate Change Cluster (C3), University of Technology Sydney, Ultimo, New South Wales, 2007, Australia.
[Ti] Título:Characterization of Gambierdiscus lapillus sp. nov. (Gonyaulacales, Dinophyceae): a new toxic dinoflagellate from the Great Barrier Reef (Australia).
[So] Source:J Phycol;53(2):283-297, 2017 Apr.
[Is] ISSN:1529-8817
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Gambierdiscus is a genus of benthic dinoflagellates found worldwide. Some species produce neurotoxins (maitotoxins and ciguatoxins) that bioaccumulate and cause ciguatera fish poisoning (CFP), a potentially fatal food-borne illness that is common worldwide in tropical regions. The investigation of toxigenic species of Gambierdiscus in CFP endemic regions in Australia is necessary as a first step to determine which species of Gambierdiscus are related to CFP cases occurring in this region. In this study, we characterized five strains of Gambierdiscus collected from Heron Island, Australia, a region in which ciguatera is endemic. Clonal cultures were assessed using (i) light microscopy; (ii) scanning electron microscopy; (iii) DNA sequencing based on the nuclear encoded ribosomal 18S and D8-D10 28S regions; (iv) toxicity via mouse bioassay; and (v) toxin profile as determined by Liquid Chromatography-Mass Spectrometry. Both the morphological and phylogenetic data indicated that these strains represent a new species of Gambierdiscus, G. lapillus sp. nov. (plate formula Po, 3', 0a, 7″, 6c, 7-8s, 5‴, 0p, 2″″ and distinctive by size and hatchet-shaped 2' plate). Culture extracts were found to be toxic using the mouse bioassay. Using chemical analysis, it was determined that they did not contain maitotoxin (MTX1) or known algal-derived ciguatoxin analogs (CTX3B, 3C, CTX4A, 4B), but that they contained putative MTX3, and likely other unknown compounds.
[Mh] Termos MeSH primário: Dinoflagelados/classificação
Dinoflagelados/metabolismo
[Mh] Termos MeSH secundário: Animais
Austrália
Intoxicação por Ciguatera
Ciguatoxinas/metabolismo
Dinoflagelados/genética
Toxinas Marinhas/metabolismo
Oxocinas/metabolismo
Filogenia
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Marine Toxins); 0 (Oxocins); 11050-21-8 (Ciguatoxins); 9P59GES78D (maitotoxin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161126
[St] Status:MEDLINE
[do] DOI:10.1111/jpy.12496


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[PMID]:27584136
[Au] Autor:Derian A; Khurana S; Rothenberg J; Plumlee C
[Ad] Endereço:From the Department of Physical Medicine and Rehabilitation, University of Miami/Jackson Memorial Hospital, Miami, Florida.
[Ti] Título:Intractable Seizures and Rehabilitation in Ciguatera Poisoning.
[So] Source:Am J Phys Med Rehabil;96(5):e89-e92, 2017 May.
[Is] ISSN:1537-7385
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ciguatera fish poisoning is the most frequently reported seafood toxin illness associated with the ingestion of contaminated tropical fish. Diagnosis relies on a history of recent tropical fish ingestion and subsequent development of gastrointestinal, cardiovascular, and neurological symptoms. Ciguatera poisoning usually has a self-limited time course, and its management involves symptomatic control and supportive care. This case report presents an uncommon case of ciguatera poisoning with prolonged intractable seizures refractory to standard antiseizure medications. The patient also had significant functional decline that responded to rigorous inpatient rehabilitation not previously described in literature.
[Mh] Termos MeSH primário: Intoxicação por Ciguatera/reabilitação
Convulsões/reabilitação
[Mh] Termos MeSH secundário: Adolescente
Animais
Anticonvulsivantes/uso terapêutico
Intoxicação por Ciguatera/complicações
Transtornos Neurológicos da Marcha/etiologia
Transtornos Neurológicos da Marcha/reabilitação
Seres Humanos
Masculino
Testes Neuropsicológicos
Modalidades de Fisioterapia
Piracetam/análogos & derivados
Piracetam/uso terapêutico
Convulsões/tratamento farmacológico
Convulsões/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticonvulsants); 230447L0GL (etiracetam); ZH516LNZ10 (Piracetam)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160902
[St] Status:MEDLINE
[do] DOI:10.1097/PHM.0000000000000606


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[PMID]:27160878
[Au] Autor:Thompson CA; Jazuli F; Taggart LR; Boggild AK
[Ad] Endereço:London School of Hygiene & Tropical Medicine (Thompson), London, UK; Faculty of Medicine (Jazuli), University of Toronto; Department of Medicine (Taggart, Boggild), University of Toronto; Division of Infectious Diseases (Taggart), St. Michael's Hospital, Toronto, Ont.; Tropical Disease Unit, Div
[Ti] Título:Ciguatera fish poisoning after Caribbean travel.
[So] Source:CMAJ;189(1):E19-E21, 2017 01 09.
[Is] ISSN:1488-2329
[Cp] País de publicação:Canada
[La] Idioma:eng
[Mh] Termos MeSH primário: Intoxicação por Ciguatera/diagnóstico
Viagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Região do Caribe
Intoxicação por Ciguatera/etiologia
Intoxicação por Ciguatera/terapia
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160511
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.151207


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[PMID]:27806035
[Au] Autor:Armstrong P; Murray P; Nesdale A; Peckler B
[Ad] Endereço:Emergency Medicine Registrar, Emergency Department, Wellington Hospital, Wellington.
[Ti] Título:Ciguatera fish poisoning.
[So] Source:N Z Med J;129(1444):111-114, 2016 Oct 28.
[Is] ISSN:1175-8716
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Ciguatera fish poisoning (CFP) is the most common cause of seafood-toxin poisoning in the world and is most prevalent in tropical and subtropical areas. It causes gastroenteritis but also myriad neurological and cardiovascular symptoms. We present a cluster of CFP that occurred in Wellington Hospital, New Zealand. It resulted in three patients with life threatening cardiotoxicity and a fourth case with severe gastro-intestinal symptoms. The epidemiology, clinical manifestations, diagnosis, treatment and public health issues are discussed.
[Mh] Termos MeSH primário: Intoxicação por Ciguatera/epidemiologia
Ciguatoxinas/análise
Surtos de Doenças/prevenção & controle
Gastroenterite/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Intoxicação por Ciguatera/diagnóstico
Intoxicação por Ciguatera/tratamento farmacológico
Diuréticos Osmóticos/administração & dosagem
Feminino
Gastroenterite/etiologia
Seres Humanos
Masculino
Manitol/administração & dosagem
Meia-Idade
Nova Zelândia/epidemiologia
Saúde Pública/normas
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diuretics, Osmotic); 11050-21-8 (Ciguatoxins); 3OWL53L36A (Mannitol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161103
[St] Status:MEDLINE


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[PMID]:27288897
[Au] Autor:Meyer L; Capper A; Carter S; Simpfendorfer C
[Ad] Endereço:James Cook University, Centre for Sustainable Tropical Fisheries and Aquaculture, James Cook University, James Cook Drive, Townsville, QLD 4811, Australia. Electronic address: lauren.meyer@my.jcu.edu.au.
[Ti] Título:An investigation into ciguatoxin bioaccumulation in sharks.
[So] Source:Toxicon;119:234-43, 2016 Sep 01.
[Is] ISSN:1879-3150
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ciguatoxins (CTXs) produced by benthic Gambierdiscus dinoflagellates, readily biotransform and bioaccumulate in food chains ultimately bioconcentrating in high-order, carnivorous marine species. Certain shark species, often feeding at, or near the top of the food-chain have the ability to bioaccumulate a suite of toxins, from both anthropogenic and algal sources. As such, these apex predators are likely sinks for CTXs. This assumption, in conjunction with anecdotal knowledge of poisoning incidents, several non-specific feeding trials whereby various terrestrial animals were fed suspect fish flesh, and a single incident in Madagascar in 1994, have resulted in the widespread acceptance that sharks may accumulate CTXs. This prompted a study to investigate original claims within the literature, as well as investigate CTX bioaccumulation in the muscle and liver of 22 individual sharks from nine species, across four locations along the east coast of Australia. Utilizing an updated ciguatoxin extraction method with HPLC-MS/MS, we were unable to detect P-CTX-1, P-CTX-2 or P-CTX-3, the three primary CTX congeners, in muscle or liver samples. We propose four theories to address this finding: (1) to date, methods have been optimized for teleost species and may not be appropriate for elasmobranchs, or the CTXs may be below the limit of detection; (2) CTX may be biotransformed into elasmobranch-specific congeners as a result of unique metabolic properties; (3) 22 individuals may be an inadequate sample size given the rare occurrence of high-order ciguatoxic organisms and potential for CTX depuration; and (4) the ephemeral nature and inconsistent toxin profiles of Gambierdiscus blooms may have undermined our classifications of certain areas as CTX hotspots. These results, in combination with the lack of clarity within the literature, suggest that ciguatoxin bioaccumulation in sharks remains elusive, and warrants further investigation to determine the dynamics of toxin production, accumulation and transformation throughout the entire food-web.
[Mh] Termos MeSH primário: Ciguatoxinas/metabolismo
Tubarões/metabolismo
[Mh] Termos MeSH secundário: Animais
Intoxicação por Ciguatera/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
11050-21-8 (Ciguatoxins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160612
[St] Status:MEDLINE


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[PMID]:27080020
[Au] Autor:Farrell H; Zammit A; Manning J; Shadbolt C; Szabo L; Harwood DT; McNabb P; Turahui JA; van den Berg DJ
[Ad] Endereço:Shellfish Operations Officer, NSW Food Authority, Newington, New South Wales.
[Ti] Título:Clinical diagnosis and chemical confirmation of ciguatera fish poisoning in New South Wales, Australia.
[So] Source:Commun Dis Intell Q Rep;40(1):E1-6, 2016 Mar 31.
[Is] ISSN:1447-4514
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Ciguatera fish poisoning is common in tropical and sub-tropical areas and larger fish (> 10 kg) are more susceptible to toxin accumulation with age. Although the coastal climate of northern New South Wales is considered sub-tropical, prior to 2014 there has only been 1 documented outbreak of ciguatera fish poisoning from fish caught in the region. During February and March 2014, 2 outbreaks of ciguatera fish poisoning involved 4 and 9 individuals, respectively, both following consumption of Spanish mackerel from northern New South Wales coastal waters (Evans Head and Scotts Head). Affected individuals suffered a combination of gastrointestinal and neurological symptoms requiring hospital treatment. At least 1 individual was symptomatic up to 7 months later. Liquid chromatography-tandem mass spectrometry detected the compound Pacific ciguatoxin-1B at levels up to 1.0 µg kg(-1) in fish tissue from both outbreaks. During April 2015, another outbreak of ciguatera fish poisoning was reported in 4 individuals. The fish implicated in the outbreak was caught further south than the 2014 outbreaks (South West Rocks). Fish tissue was unavailable for analysis; however, symptoms were consistent with ciguatera fish poisoning. To our knowledge, these cases are the southernmost confirmed sources of ciguatera fish poisoning in Australia. Educational outreach to the fishing community, in particular recreational fishers was undertaken after the Evans Head outbreak. This highlighted the outbreak, species of fish involved and the range of symptoms associated with ciguatera fish poisoning. Further assessment of the potential for ciguatoxins to occur in previously unaffected locations need to be considered in terms of food safety.
[Mh] Termos MeSH primário: Intoxicação por Ciguatera/diagnóstico
Intoxicação por Ciguatera/epidemiologia
Ciguatoxinas/isolamento & purificação
Surtos de Doenças
Produtos Pesqueiros/toxicidade
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida
Intoxicação por Ciguatera/induzido quimicamente
Intoxicação por Ciguatera/fisiopatologia
Produtos Pesqueiros/análise
Seres Humanos
New South Wales/epidemiologia
Perciformes
Espectrometria de Massas em Tandem
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ciguatoxin 1B (CTX 1B)); 11050-21-8 (Ciguatoxins)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170111
[Lr] Data última revisão:
170111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160416
[St] Status:MEDLINE


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[PMID]:27073998
[Au] Autor:Hardison DR; Holland WC; McCall JR; Bourdelais AJ; Baden DG; Darius HT; Chinain M; Tester PA; Shea D; Quintana HA; Morris JA; Litaker RW
[Ad] Endereço:National Oceanic and Atmospheric Administration, Center for Coastal Fisheries and Habitat Research, Beaufort, North Carolina, United States of America.
[Ti] Título:Fluorescent Receptor Binding Assay for Detecting Ciguatoxins in Fish.
[So] Source:PLoS One;11(4):e0153348, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ciguatera fish poisoning is an illness suffered by > 50,000 people yearly after consumption of fish containing ciguatoxins (CTXs). One of the current methodologies to detect ciguatoxins in fish is a radiolabeled receptor binding assay (RBA(R)). However, the license requirements and regulations pertaining to radioisotope utilization can limit the applicability of the RBA(R) in certain labs. A fluorescence based receptor binding assay (RBA(F)) was developed to provide an alternative method of screening fish samples for CTXs in facilities not certified to use radioisotopes. The new assay is based on competition binding between CTXs and fluorescently labeled brevetoxin-2 (BODIPY®-PbTx-2) for voltage-gated sodium channel receptors at site 5 instead of a radiolabeled brevetoxin. Responses were linear in fish tissues spiked from 0.1 to 1.0 ppb with Pacific ciguatoxin-3C (P-CTX-3C) with a detection limit of 0.075 ppb. Carribean ciguatoxins were confirmed in Caribbean fish by LC-MS/MS analysis of the regional biomarker (C-CTX-1). Fish (N = 61) of six different species were screened using the RBA(F). Results for corresponding samples analyzed using the neuroblastoma cell-based assay (CBA-N2a) correlated well (R2 = 0.71) with those of the RBA(F), given the low levels of CTX present in positive fish. Data analyses also showed the resulting toxicity levels of P-CTX-3C equivalents determined by CBA-N2a were consistently lower than the RBA(F) affinities expressed as % binding equivalents, indicating that a given amount of toxin bound to the site 5 receptors translates into corresponding lower cytotoxicity. Consequently, the RBA(F), which takes approximately two hours to perform, provides a generous estimate relative to the widely used CBA-N2a which requires 2.5 days to complete. Other RBA(F) advantages include the long-term (> 5 years) stability of the BODIPY®-PbTx-2 and having similar results as the commonly used RBA(R). The RBA(F) is cost-effective, allows high sample throughput, and is well-suited for routine CTX monitoring programs.
[Mh] Termos MeSH primário: Intoxicação por Ciguatera/diagnóstico
Ciguatoxinas/isolamento & purificação
Peixes/metabolismo
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida
Ligação Proteica
Ratos
Ratos Sprague-Dawley
Sinaptossomos/metabolismo
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
11050-21-8 (Ciguatoxins)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160414
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0153348



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