Base de dados : MEDLINE
Pesquisa : C25.723.522.625 [Categoria DeCS]
Referências encontradas : 1598 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 160 ir para página                         

  1 / 1598 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28931793
[Au] Autor:Aoshima K
[Ad] Endereço:Hagino Hospital.
[Ti] Título:Itai-itai disease: Lessons from the investigations of environmental epidemiology conducted in the 1970's, with special reference to the studies of the Toyama Institute of Health.
[So] Source:Nihon Eiseigaku Zasshi;72(3):149-158, 2017.
[Is] ISSN:1882-6482
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:The outbreak of itai-itai disease, which is the most severe stage of chronic cadmium poisoning, has occurred in the cadmium-polluted Jinzu River basin in Toyama. In this area, the river was contaminated by slags from a mine upstream; consequently, the soil in rice paddies became polluted with heavy metals including cadmium through irrigation water streams from around 1910 to the 1960s. The inhabitants of the Jinzu River basin used the river water for drinking and cooking until around 1960. In this paper, we review the geographical features of the Jinzu River basin and the endemic area of itai-itai disease, and reevaluated the studies conducted in 1970's by the Toyama Institute of Health, because these studies have revealed a clear relationship between renal dysfunction or occurrence of itai-itai disease and exposure to cadmium through irrigation water streams.
[Mh] Termos MeSH primário: Intoxicação por Cádmio/epidemiologia
Intoxicação por Cádmio/etiologia
Cádmio/toxicidade
Poluentes Químicos da Água/toxicidade
Poluição Química da Água
[Mh] Termos MeSH secundário: Exposição Ambiental
Feminino
Seres Humanos
Japão/epidemiologia
Masculino
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); 00BH33GNGH (Cadmium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1265/jjh.72.149


  2 / 1598 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28583137
[Au] Autor:Jafarpour D; Shekarforoush SS; Ghaisari HR; Nazifi S; Sajedianfard J; Eskandari MH
[Ad] Endereço:Department of Food Hygiene and Public Health, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
[Ti] Título:Protective effects of synbiotic diets of Bacillus coagulans, Lactobacillus plantarum and inulin against acute cadmium toxicity in rats.
[So] Source:BMC Complement Altern Med;17(1):291, 2017 Jun 05.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cadmium is a heavy metal that causes oxidative stress and has toxic effects in humans. The aim of this study was to investigate the influence of two probiotics along with a prebiotic in preventing the toxic effects of cadmium in rats. METHODS: Twenty-four male Wistar rats were randomly divided into four groups namely control, cadmium only, cadmium along with Lactobacillus plantarum (1 × 109 CFU/day) and inulin (5% of feedstuff) and cadmium along with Bacillus coagulans (1 × 109 spore/day) and inulin (5% of feedstuff). Cadmium treated groups received 200 µg/rat/day CdCl2 administered by gavage. During the 42-day experimental period, they were weighed weekly. For evaluation of changes in oxidative stress, the levels of some biochemicals and enzymes of serum including SOD, GPX, MDA, AST, ALT, total bilirubin, BUN and creatinine, and also SOD level of livers were measured at day 21 and 42 of treatment. The cadmium content of kidney and liver was determined by using atomic absorption mass spectrophotometry. Data were analyzed using analysis of variance (ANOVA) followed by Duncan's post hoc test. RESULTS: Treatment of cadmium induced rats with synbiotic diets significantly improved the liver enzymes and biochemical parameters that decreased AST, ALT, total bilirubin, BUN and metal accumulation in the liver and kidney and increased body weight, serum and liver SOD values in comparison with the cadmium-treated group. No significant differences were observed with MDA and GP values between all groups (p > 0.05). CONCLUSIONS: This study showed that synbiotic diets containing probiotics (L. plantarum and B. coagulans) in combination with the prebiotic (inulin) can reduce the level of cadmium in the liver and kidney, preventing their damage and recover antioxidant enzymes in acute cadmium poisoning in rat.
[Mh] Termos MeSH primário: Bacillus coagulans/fisiologia
Intoxicação por Cádmio/prevenção & controle
Cádmio/toxicidade
Inulina/administração & dosagem
Lactobacillus plantarum/fisiologia
Substâncias Protetoras/administração & dosagem
Simbióticos/administração & dosagem
[Mh] Termos MeSH secundário: Doença Aguda/terapia
Animais
Intoxicação por Cádmio/microbiologia
Seres Humanos
Masculino
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protective Agents); 00BH33GNGH (Cadmium); 9005-80-5 (Inulin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1803-3


  3 / 1598 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28348417
[Au] Autor:Favorito R; Monaco A; Grimaldi MC; Ferrandino I
[Ad] Endereço:University of Naples Federico II, Department of Biology. rossana.favorito@unina.it.
[Ti] Título:Effects of cadmium on the glial architecture in lizard brain.
[So] Source:Eur J Histochem;61(1):2734, 2017 Jan 23.
[Is] ISSN:2038-8306
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:The glial cells are positioned to be the first cells of the brain parenchyma to face molecules crossing the blood-brain barrier with a relevant neuroprotective role from cytotoxic action of heavy metals on the nervous system. Cadmium is a highly toxic metal and its levels in the environment are increasing due to industrial activities. This element can pass the blood-brain barrier and have neurotoxic activity. For this reason we have studied the effects of cadmium on the glial architecture in the lizard Podarcis siculus, a significant bioindicator of chemical exposure due to its persistence in a variety of habitats. The study was performed on two groups of lizards. The first group of P. siculus was exposed to an acute treatment by a single i.p. injection (2 mg/kg-BW) of CdCl2 and sacrificed after 2, 7 and 16 days. The second one was used as control. The histology of the brain was studied by Hematoxylin/Eosin and Cresyl/Violet stains while the glial structures were analyzed by immunodetection of the glial fibrillary acidic protein (GFAP), the most widely accepted marker for astroglial cells. Evident morphological alterations of the brain were observed at 7 and 16 days from the injection, when we revealed also a decrease of the GFAP-immunopositive structures in particular in the rhombencephalic ventricle, telencephalon and optic tectum. These results show that in the lizards an acute exposure to cadmium provokes morphological cellular alterations in the brain but also a decrement of the expression of GFAP marker with possible consequent damage of glial cells functions.
[Mh] Termos MeSH primário: Encéfalo
Cloreto de Cádmio
Intoxicação por Cádmio
Proteína Glial Fibrilar Ácida/biossíntese
Neuroglia
[Mh] Termos MeSH secundário: Animais
Encéfalo/metabolismo
Encéfalo/patologia
Intoxicação por Cádmio/metabolismo
Intoxicação por Cádmio/patologia
Lagartos
Neuroglia/metabolismo
Neuroglia/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glial Fibrillary Acidic Protein); J6K4F9V3BA (Cadmium Chloride)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170329
[St] Status:MEDLINE
[do] DOI:10.4081/ejh.2017.2734


  4 / 1598 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27981852
[Au] Autor:Park SS; Skaar DA; Jirtle RL; Hoyo C
[Ad] Endereço:Department of Biological Sciences, Center for Human Health & the Environment, North Carolina State University, Raleigh, NC 27695 USA.
[Ti] Título:Epigenetics, obesity and early-life cadmium or lead exposure.
[So] Source:Epigenomics;9(1):57-75, 2017 Jan.
[Is] ISSN:1750-192X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Obesity is a complex and multifactorial disease, which likely comprises multiple subtypes. Emerging data have linked chemical exposures to obesity. As organismal response to environmental exposures includes altered gene expression, identifying the regulatory epigenetic changes involved would be key to understanding the path from exposure to phenotype and provide new tools for exposure detection and risk assessment. In this report, we summarize published data linking early-life exposure to the heavy metals, cadmium and lead, to obesity. We also discuss potential mechanisms, as well as the need for complete coverage in epigenetic screening to fully identify alterations. The keys to understanding how metal exposure contributes to obesity are improved assessment of exposure and comprehensive establishment of epigenetic profiles that may serve as markers for exposures.
[Mh] Termos MeSH primário: Intoxicação por Cádmio/epidemiologia
Epigênese Genética
Intoxicação por Chumbo/epidemiologia
Obesidade/epidemiologia
[Mh] Termos MeSH secundário: Animais
Intoxicação por Cádmio/genética
Metilação de DNA
Microbioma Gastrointestinal/efeitos dos fármacos
Microbioma Gastrointestinal/genética
Seres Humanos
Intoxicação por Chumbo/genética
Obesidade/genética
Obesidade/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE
[do] DOI:10.2217/epi-2016-0047


  5 / 1598 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27976972
[Au] Autor:Djurasevic S; Jama A; Jasnic N; Vujovic P; Jovanovic M; Mitic-Culafic D; Knezevic-Vukcevic J; Cakic-Milosevic M; Ilijevic K; Djordjevic J
[Ad] Endereço:1 Faculty of Biology, University of Belgrade , Belgrade, Serbia .
[Ti] Título:The Protective Effects of Probiotic Bacteria on Cadmium Toxicity in Rats.
[So] Source:J Med Food;20(2):189-196, 2017 Feb.
[Is] ISSN:1557-7600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:One of the useful properties of probiotic bacteria is their capacity to bind different targets, thus eliminating them through feces. It is supposed that one of these targets could be cadmium, a widespread environmental toxicant that causes various disturbances in biological systems. This study examined the protective effects of probiotic supplementation against cadmium-induced toxicity in the rat. The experiment was conducted in the course of 5 weeks. Animals were divided into four groups: (1) controls, (2) probiotics treated, (3) cadmium treated, and (4) probiotics + cadmium treated. The cadmium concentration was measured in the blood, liver, kidney, and feces, as well as the blood alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as biomarkers of the liver function. Histomorphological changes in the liver and kidney were also determined. Our results revealed that probiotics combined with cadmium increase this metal concentration in feces. As a result, blood, liver, and kidney Cd levels, as well as blood ALT and AST activities were lessened compared to the rat group treated with cadmium only. Besides, probiotics consumed simultaneously with cadmium attenuated histomorphological changes in the liver and kidney caused by cadmium. The rise in lactobacilli number in feces of rats treated simultaneously with cadmium and probiotics results in strong correlation with the increase of Cd concentration in their feces and the decrease of Cd concentration in their blood. We speculate that probiotics actively contribute to cadmium excretion through feces, probably, by its binding to their bacterial cell wall.
[Mh] Termos MeSH primário: Intoxicação por Cádmio/tratamento farmacológico
Cádmio/toxicidade
Probióticos/administração & dosagem
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Animais
Aspartato Aminotransferases/sangue
Bifidobacterium longum/metabolismo
Cádmio/metabolismo
Intoxicação por Cádmio/sangue
Seres Humanos
Rim/efeitos dos fármacos
Rim/metabolismo
Lactobacillus acidophilus/metabolismo
Lactobacillus rhamnosus/metabolismo
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
00BH33GNGH (Cadmium); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE
[do] DOI:10.1089/jmf.2016.0090


  6 / 1598 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27561294
[Au] Autor:Zhang R; Wang Y; Wang C; Zhao P; Liu H; Li J; Bao J
[Ad] Endereço:College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
[Ti] Título:Ameliorative Effects of Dietary Selenium Against Cadmium Toxicity Is Related to Changes in Trace Elements in Chicken Kidneys.
[So] Source:Biol Trace Elem Res;176(2):391-400, 2017 Apr.
[Is] ISSN:1559-0720
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The ameliorative effects of selenium (Se) against cadmium (Cd)-induced toxicity have been reported extensively. However, few studies have assessed the effects of multiple ions simultaneously on the variations of elements. In this study, the changes in Se, Cd, and 26 other element concentrations were investigated in chicken kidneys. One hundred and twenty-eight 31-week-old laying hens were fed a diet supplemented with either Se, Cd, or both Se and Cd for 90 days. The ion content was analyzed by inductively coupled plasma mass spectrometry (ICP-MS). We found that the Se, Cd, and combined Se and Cd treatments significantly affected the trace elements in the chicken kidneys. The Cd supplement caused ion profile disorders, including reduced concentrations of V, Cr, Mn, Mo, As, Ba, Hg, Ti, and Pb and increased Si, Cu, Li, Cd, and Sb. The Se supplement reduced the contents of Co, Mo, and Pb and increased the contents of Cr, Fe, and Se. Moreover, Se also increased the concentrations of Cr, Mn, Zn, and Se and decreased those of Li and Pb, which in contrast were induced by Cd. Complex interactions between elements were analyzed, and both positive and negative correlations among these elements are presented. The present study indicated that Se can help against the negative effects of Cd and may be related to the homeostasis of the trace elements in chicken kidneys.
[Mh] Termos MeSH primário: Intoxicação por Cádmio/prevenção & controle
Cádmio/toxicidade
Galinhas/metabolismo
Suplementos Nutricionais
Rim/efeitos dos fármacos
Rim/metabolismo
Selênio/administração & dosagem
Selênio/farmacologia
Oligoelementos/metabolismo
[Mh] Termos MeSH secundário: Animais
Cádmio/metabolismo
Espectrometria de Massas
Selênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Trace Elements); 00BH33GNGH (Cadmium); H6241UJ22B (Selenium)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160827
[St] Status:MEDLINE
[do] DOI:10.1007/s12011-016-0825-x


  7 / 1598 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26663770
[Au] Autor:Izaguirry AP; Soares MB; Vargas LM; Spiazzi CC; Dos Santos Brum D; Noremberg S; Mendez AS; Santos FW
[Ad] Endereço:Laboratório De Biotecnologia Da Reprodução (Biotech), Campus Uruguaiana, Universidade Federal Do Pampa, CEP 97500-970, Uruguaiana, Rio Grande do Sul, Brazil.
[Ti] Título:Blueberry (Vaccinium ashei Reade) extract ameliorates ovarian damage induced by subchronic cadmium exposure in mice: Potential δ-ALA-D involvement.
[So] Source:Environ Toxicol;32(1):188-196, 2017 Jan.
[Is] ISSN:1522-7278
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Females are born with a finite number of oocyte-containing follicles and ovary damage results in reduced fertility. Cadmium accumulates in the reproductive system, damaging it, and the cigarette smoke is a potential exposure route. Natural therapies are relevant to health benefits and disease prevention. This study verified the effect of cadmium exposure on the ovaries of mice and the blueberry extract as a potential therapy. Blueberry therapy was effective in restoring reactive species levels and δ-aminolevulinate dehydratase activity, and partially improved the viability of cadmium-disrupted follicles. This therapy was not able to restore the 17 ß-hydroxysteroid dehydrogenase activity. Extract HPLC evaluation indicated the presence of quercetin, quercitrin, isoquercetin, and ascorbic acid. Ascorbic acid was the major substance and its concentration was 620.24 µg/mL. Thus, cadmium accumulates in the ovaries of mice after subchronic exposure, inducing cellular damage, and the blueberry extract possesses antioxidant properties that could protect, at least in part, the ovarian tissue from cadmium toxicity. © 2015 Wiley Periodicals, Inc. Environ Toxicol 32: 188-196, 2017.
[Mh] Termos MeSH primário: Mirtilos Azuis (Planta)/química
Intoxicação por Cádmio/tratamento farmacológico
Doenças Ovarianas/induzido quimicamente
Doenças Ovarianas/tratamento farmacológico
Extratos Vegetais/farmacologia
Sintase do Porfobilinogênio/metabolismo
[Mh] Termos MeSH secundário: 11-beta-Hidroxiesteroide Desidrogenases/metabolismo
Animais
Intoxicação por Cádmio/patologia
Feminino
Glutationa Peroxidase/metabolismo
Glutationa Sintase/metabolismo
Camundongos
Doenças Ovarianas/patologia
Folículo Ovariano/efeitos dos fármacos
Sintase do Porfobilinogênio/efeitos dos fármacos
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Reactive Oxygen Species); EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenases); EC 1.11.1.9 (Glutathione Peroxidase); EC 4.2.1.24 (Porphobilinogen Synthase); EC 6.3.2.3 (Glutathione Synthase)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE
[do] DOI:10.1002/tox.22225


  8 / 1598 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26592365
[Au] Autor:da Costa P; Gonçalves JF; Baldissarelli J; Mann TR; Abdalla FH; Fiorenza AM; da Rosa MM; Carvalho FB; Gutierres JM; de Andrade CM; Rubin MA; Schetinger MR; Morsch VM
[Ad] Endereço:Departamento De Bioquímica E Biologia Molecular, Centro De Ciências Naturais E Exatas, Universidade Federal De Santa Maria, Campus Universitário, Camobi, Santa Maria, RS, 97105-900, Brasil.
[Ti] Título:Curcumin attenuates memory deficits and the impairment of cholinergic and purinergic signaling in rats chronically exposed to cadmium.
[So] Source:Environ Toxicol;32(1):70-83, 2017 Jan.
[Is] ISSN:1522-7278
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study investigated the protective effect of curcumin on memory loss and on the alteration of acetylcholinesterase and ectonucleotidases activities in rats exposed chronically to cadmium (Cd). Rats received Cd (1 mg/kg) and curcumin (30, 60, or 90 mg/kg) by oral gavage 5 days a week for 3 months. The animals were divided into eight groups: vehicle (saline/oil), saline/curcumin 30 mg/kg, saline/curcumin 60 mg/kg, saline/curcumin 90 mg/kg, Cd/oil, Cd/curcumin 30 mg/kg, Cd/curcumin 60 mg/kg, and Cd/curcumin 90 mg/kg. Curcumin prevented the decrease in the step-down latency induced by Cd. In cerebral cortex synaptosomes, Cd-exposed rats showed an increase in acetylcholinesterase and NTPDase (ATP and ADP as substrates) activities and a decrease in the 5'-nucleotidase activity. Curcumin was not able to prevent the effect of Cd on acetylcholinesterase activity, but it prevented the effects caused by Cd on NTPDase (ATP and ADP as substrate) and 5'-nucleotidase activities. Increased acetylcholinesterase activity was observed in different brain structures, whole blood and lymphocytes of the Cd-treated group. In addition, Cd increased lipid peroxidation in different brain structures. Higher doses of curcumin were more effective in preventing these effects. These findings show that curcumin prevented the Cd-mediated memory impairment, demonstrating that this compound has a neuroprotective role and is capable of modulating acetylcholinesterase, NTPDase, and 5'-nucleotidase activities. Finally, it highlights the possibility of using curcumin as an adjuvant against toxicological conditions involving Cd exposure. © 2015 Wiley Periodicals, Inc. Environ Toxicol 32: 70-83, 2017.
[Mh] Termos MeSH primário: Intoxicação por Cádmio/fisiopatologia
Curcumina/uso terapêutico
Transtornos da Memória/induzido quimicamente
Transtornos da Memória/prevenção & controle
Sistema Nervoso Parassimpático/efeitos dos fármacos
Receptores Purinérgicos/efeitos dos fármacos
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Aprendizagem da Esquiva/efeitos dos fármacos
Intoxicação por Cádmio/enzimologia
Curcumina/administração & dosagem
Relação Dose-Resposta a Droga
Eletrochoque
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Atividade Motora/efeitos dos fármacos
Ratos
Ratos Wistar
Sinaptossomos/efeitos dos fármacos
Sinaptossomos/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Purinergic); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151124
[St] Status:MEDLINE
[do] DOI:10.1002/tox.22213


  9 / 1598 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27614986
[Au] Autor:Caldas D; Pestana IA; Almeida MG; Henry FC; Salomão MS; de Souza CM
[Ad] Endereço:Laboratório de Ciências Ambientais, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Rio de Janeiro, RJ, CEP: 28013-602, Brazil. Electronic address: dayana_caldascardoso@yahoo.com.br.
[Ti] Título:Risk of ingesting As, Cd, and Pb in animal products in north Rio de Janeiro state, Brazil.
[So] Source:Chemosphere;164:508-515, 2016 Dec.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study evaluated the levels of As, Cd, and Pb in muscle and liver the cattle and chicken. The risk was estimated for the adult population of a midsized city in southeast Brazil, concerning the tolerable ingestion and cancer risk. Samples of muscle and liver (cattle and chicken) were collected (n = 250). Samples of mineral supplements for cattle (n = 4) and chicken feed samples (n = 4) were evaluated as one of many potential source of contamination. Muscle, liver, mineral supplement, and feed samples were dissolved in acid medium and analyzed by ICP-OES. Daily muscle and liver intake was estimated using a questionnaire (N = 427). Daily intake of trace elements by the population based on the consumption of cattle muscle, cattle liver, chicken muscle, and chicken liver was low, corresponding to 2.76%, 0.33%, 2.12%, and 0.22% of the Tolerable Intake defined by the WHO for As; 0.54%, 0.29% 0.55%, 0.01%, for Cd; and 0.80%, 0.07%, 0.62%, 0.02%, for Pb. The mean of total ingestion of As, Cd and Pb was 5.43%, 1.18% and 1.51%, respectively of Tolerable Intake defined by WHO. Cancer risk was lower than 5 × 10 year . The results indicate that the muscle and liver consumption is a source of As, Cd, and Pb. Consumers that ingest cattle and chicken muscle need attention in terms the risk of cancer related to intake of As and Cd. Feed and mineral supplementation remain as one of many sources of exposure of As, Cd, and Pb.
[Mh] Termos MeSH primário: Arsênico/farmacocinética
Cádmio/farmacocinética
Contaminação de Alimentos/análise
Chumbo/farmacocinética
Fígado/metabolismo
Músculos/metabolismo
Neoplasias/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Animais
Arsênico/análise
Arsênico/toxicidade
Intoxicação por Arsênico/epidemiologia
Intoxicação por Arsênico/etiologia
Brasil/epidemiologia
Cádmio/análise
Cádmio/toxicidade
Intoxicação por Cádmio/epidemiologia
Intoxicação por Cádmio/etiologia
Bovinos
Galinhas
Feminino
Seres Humanos
Chumbo/análise
Chumbo/toxicidade
Intoxicação por Chumbo/epidemiologia
Intoxicação por Chumbo/etiologia
Masculino
Neoplasias/etiologia
Medição de Risco
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
00BH33GNGH (Cadmium); 2P299V784P (Lead); N712M78A8G (Arsenic)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160912
[St] Status:MEDLINE


  10 / 1598 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27208136
[Au] Autor:Zhai Q; Tian F; Zhao J; Zhang H; Narbad A; Chen W
[Ad] Endereço:State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, People's Republic of China UK-China Joint Centre on Probiotic Bacteria, Norwich, United Kingdom.
[Ti] Título:Oral Administration of Probiotics Inhibits Absorption of the Heavy Metal Cadmium by Protecting the Intestinal Barrier.
[So] Source:Appl Environ Microbiol;82(14):4429-40, 2016 Jul 15.
[Is] ISSN:1098-5336
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: The heavy metal cadmium (Cd) is an environmental pollutant that causes adverse health effects in humans and animals. Our previous work demonstrated that oral administration of probiotics can significantly inhibit Cd absorption in the intestines of mice, but further evidence is needed to gain insights into the related protection mode. The goal of this study was to evaluate whether probiotics can inhibit Cd absorption through routes other than the Cd binding, with a focus on gut barrier protection. In the in vitro assay, both the intervention and therapy treatments of Lactobacillus plantarum CCFM8610 alleviated Cd-induced cytotoxicity in the human intestinal cell line HT-29 and protected the disruption of tight junctions in the cell monolayers. In a mouse model, probiotics with either good Cd-binding or antioxidative ability increased fecal Cd levels and decreased Cd accumulation in the tissue of Cd-exposed mice. Compared with the Cd-only group, cotreatment with probiotics also reversed the disruption of tight junctions, alleviated inflammation, and decreased the intestinal permeability of mice. L. plantarum CCFM8610, a strain with both good Cd binding and antioxidative abilities, exhibited significantly better protection than the other two strains. These results suggest that along with initial intestinal Cd sequestration, probiotics can inhibit Cd absorption by protecting the intestinal barrier, and the protection is related to the alleviation of Cd-induced oxidative stress. A probiotic with both good Cd-binding and antioxidative capacities can be used as a daily supplement for the prevention of oral Cd exposure. IMPORTANCE: The heavy metal cadmium (Cd) is an environmental pollutant that causes adverse health effects in humans and animals. For the general population, food and drinking water are the main sources of Cd exposure due to the biomagnification of Cd within the food chain; therefore, the intestinal tract is the first organ that is susceptible to Cd contamination. Moreover, Cd exposure causes the disruption of the intestinal barrier and further induces the amplification of Cd absorption. The present study confirms that, along with initial intestinal Cd sequestration, oral administration of probiotics can inhibit Cd absorption by protecting the intestinal barrier. A probiotic with both good Cd-binding and antioxidative capacities can be used as a daily supplement for the prevention of oral Cd exposure.
[Mh] Termos MeSH primário: Adsorção
Intoxicação por Cádmio/prevenção & controle
Intoxicação por Cádmio/terapia
Cádmio/metabolismo
Lactobacillus plantarum/metabolismo
Metais Pesados/metabolismo
Probióticos/administração & dosagem
[Mh] Termos MeSH secundário: Administração Oral
Animais
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Modelos Animais de Doenças
Células Epiteliais/efeitos dos fármacos
Células Epiteliais/fisiologia
Seres Humanos
Intestinos/efeitos dos fármacos
Intestinos/fisiologia
Camundongos
Permeabilidade
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy); 00BH33GNGH (Cadmium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160522
[St] Status:MEDLINE
[do] DOI:10.1128/AEM.00695-16



página 1 de 160 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde