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Pesquisa : C25.723.717 [Categoria DeCS]
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[PMID]:28743514
[Au] Autor:Herbert J; Thiermann H; Worek F; Wille T
[Ad] Endereço:Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany.
[Ti] Título:Precision cut lung slices as test system for candidate therapeutics in organophosphate poisoning.
[So] Source:Toxicology;389:94-100, 2017 08 15.
[Is] ISSN:1879-3185
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Standard therapeutic options in organophosphate (OP) poisoning are limited to the administration of atropine and oximes, a regimen often lacking in efficacy and applicability. Treatment alternatives are needed, preferably covering a broad spectrum of OP intoxications. Although recent research yielded several promising compounds, e.g. bioscavengers, modulators of the muscarinic acetylcholine (ACh) receptor or bispyridinium non-oximes, these substances still need further evaluation, especially regarding effects on the potentially lethal respiratory symptoms of OP poisoning. Aim of this study was the development of an applicable and easy method to test the therapeutic efficiency of such substances. For this purpose, airway responsiveness in viable precision cut lung slices (PCLS) from rats was analysed. We showed that ACh-induced airway contractions were spontaneously reversible in non-poisoned PCLS, whereas in OP poisoned PCLS, contractions were irreversible. This effect could be antagonized by addition of the standard therapeutic atropine, thereby presenting a clear indication for treatment efficiency. Now, candidate therapeutic compounds can be evaluated, based on their ability to counteract the irreversible airway contraction in OP poisoned PCLS.
[Mh] Termos MeSH primário: Antídotos/farmacologia
Atropina/farmacologia
Broncoconstrição/efeitos dos fármacos
Broncodilatadores/farmacologia
Descoberta de Drogas/métodos
Pulmão/efeitos dos fármacos
Antagonistas Muscarínicos/farmacologia
Contração Muscular/efeitos dos fármacos
Músculo Liso/efeitos dos fármacos
Agentes Neurotóxicos/toxicidade
Intoxicação por Organofosfatos/tratamento farmacológico
Organofosfatos/toxicidade
[Mh] Termos MeSH secundário: Acetilcolina/farmacologia
Animais
Relação Dose-Resposta a Droga
Pulmão/fisiopatologia
Masculino
Músculo Liso/fisiopatologia
Intoxicação por Organofosfatos/fisiopatologia
Ratos Wistar
Fatores de Tempo
Técnicas de Cultura de Tecidos
Sobrevivência de Tecidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antidotes); 0 (Bronchodilator Agents); 0 (Muscarinic Antagonists); 0 (Nerve Agents); 0 (Organophosphates); 7C0697DR9I (Atropine); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


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[PMID]:28711273
[Au] Autor:Turkdogan KA; Duman A; Avcil M; Akoz A; Canakci SE; Kantekin B
[Ad] Endereço:Adnan Menderes University, Department of Emergency Medicine, Aydin, Turkey. Electronic address: ahmet.turkdogan@adu.edu.tr.
[Ti] Título:Treatment methods following suicidal self-administration of IV organophosphate: What can additional lipid administration change?
[So] Source:Am J Emerg Med;35(9):1388.e3-1388.e5, 2017 Sep.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Organic phosphor compounds are highly toxic and life-threatening compounds that are widely used in agriculture, households and gardens worldwide. While oral intakes are observed frequently, toxic effects can also be seen through contract or inhalation. However, toxic cases through the parenteral route have rarely been reported. We had three main aims: first, to present a male patient who self-administered 2ml of monocrotophos intravenously to commit suicide. Our second goal was to present the current multiple treatment methods, such as fast general support, antidote treatment, lipid emulsion treatment, and plasmapheresis along with the literature. Third, we aimed to emphasize that with these treatments, patients' intensive care needs, intermediate symptoms, and hospitalization periods can be decreased and thus mortality and morbidity increase can be prevented.
[Mh] Termos MeSH primário: Antídotos/uso terapêutico
Emulsões Gordurosas Intravenosas/uso terapêutico
Intoxicação por Organofosfatos/tratamento farmacológico
Organofosfatos/toxicidade
Tentativa de Suicídio
[Mh] Termos MeSH secundário: Administração Intravenosa
Adolescente
Cuidados Críticos
Hospitalização
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidotes); 0 (Fat Emulsions, Intravenous); 0 (Organophosphates)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170717
[St] Status:MEDLINE


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[PMID]:28640122
[Au] Autor:Dong H; Weng YB; Zhen GS; Li FJ; Jin AC; Liu J
[Ad] Endereço:Emergency Internal Medicine, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
[Ti] Título:Clinical emergency treatment of 68 critical patients with severe organophosphorus poisoning and prognosis analysis after rescue.
[So] Source:Medicine (Baltimore);96(25):e7237, 2017 Jun.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study reports the clinical emergency treatment of 68 critical patients with severe organophosphorus poisoning, and analyzes the prognosis after rescue.The general data of 68 patients with severe organophosphorus poisoning treated in our hospital were retrospectively analyzed. These patients were divided into 2 groups: treatment group, and control group. Patients in the control group received routine emergency treatment, while patients in the treatment group additionally received hemoperfusion plus hemodialysis on the basis of routine emergency treatment. The curative effects in these 2 groups and the prognosis after rescue were compared.Compared with the control group, atropinization time, recovery time of cholinesterase activity, recovery time of consciousness, extubation time, and length of hospital stay were shorter (P < .05); the total usage of atropine was significantly lower (P < .05); Glasgow Coma Score was significantly higher (P < .05); acute physiology and chronic health score (APACHE II) was significantly lower (P < .05); and mortality and poisoning rebound rate was significantly lower (P < .05) in the treatment group.Hemoperfusion and hemodialysis on the basis of routine emergency treatment for critical patients with organophosphorus poisoning can improve rescue outcomes and improve the prognosis of patients, which should be popularized.
[Mh] Termos MeSH primário: Tratamento de Emergência
Hemoperfusão
Intoxicação por Organofosfatos/terapia
Diálise Renal
[Mh] Termos MeSH secundário: APACHE
Adulto
Idoso
Tratamento de Emergência/efeitos adversos
Feminino
Escala de Coma de Glasgow
Hemoperfusão/efeitos adversos
Seres Humanos
Tempo de Internação
Masculino
Meia-Idade
Intoxicação por Organofosfatos/complicações
Intoxicação por Organofosfatos/diagnóstico
Intoxicação por Organofosfatos/mortalidade
Prognóstico
Diálise Renal/efeitos adversos
Estudos Retrospectivos
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007237


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[PMID]:28569609
[Au] Autor:Gorecki L; Korabecny J; Musilek K; Nepovimova E; Malinak D; Kucera T; Dolezal R; Jun D; Soukup O; Kuca K
[Ad] Endereço:a Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences , University of Defence , Hradec Kralove , Czech Republic.
[Ti] Título:Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016).
[So] Source:Expert Opin Ther Pat;27(9):971-985, 2017 Sep.
[Is] ISSN:1744-7674
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: organophosphorus compounds act as irreversible inhibitors of the vital enzyme acetylcholinesterase (AChE). this leads in the accumulation of acetylcholine (ACh) leading to cholinergic crisis and death. The main therapeutic approach is based on immediate administration of an ache reactivator as an antidote enabling recovery of the ache function. Areas covered: This review covers the development of AChE reactivators in order to introduce a new efficient drug that will overcome significant failures of common antidotes. Further options together with methods of detection are also discussed in order to assure a complete insight into the treatment of intoxication. Expert opinion: Since organophosphates belong to the most toxic chemical warfare agents, efficient antidotes are a matter of importance. The solution of how to limit the basic drawbacks of clinically used reactivators remained a spotlight for many researches worldwide. Recent strategies of the treatment of OP exposure bring us new possibilities which may overcome classic antidotes. The importance of detection of OP also has to be taken into consideration. Especially, with the fast spreading toxic effect when death can occur within minutes.
[Mh] Termos MeSH primário: Antídotos/farmacologia
Reativadores da Colinesterase/farmacologia
Intoxicação por Organofosfatos/tratamento farmacológico
[Mh] Termos MeSH secundário: Acetilcolinesterase/efeitos dos fármacos
Acetilcolinesterase/metabolismo
Animais
Substâncias para a Guerra Química/envenenamento
Inibidores da Colinesterase/envenenamento
Desenho de Drogas
Seres Humanos
Intoxicação por Organofosfatos/fisiopatologia
Compostos Organofosforados/antagonistas & inibidores
Compostos Organofosforados/toxicidade
Patentes como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antidotes); 0 (Chemical Warfare Agents); 0 (Cholinesterase Inhibitors); 0 (Cholinesterase Reactivators); 0 (Organophosphorus Compounds); EC 3.1.1.7 (Acetylcholinesterase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1080/13543776.2017.1338275


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[PMID]:28542985
[Au] Autor:Masson P; Nachon F
[Ad] Endereço:Neuropharmacology Laboratory, Kazan Federal University, Kazan, Russia.
[Ti] Título:Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning.
[So] Source:J Neurochem;142 Suppl 2:26-40, 2017 Aug.
[Is] ISSN:1471-4159
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Organophosphorus agents (OPs) irreversibly inhibit acetylcholinesterase (AChE) causing a major cholinergic syndrome. The medical counter-measures of OP poisoning have not evolved for the last 30 years with carbamates for pretreatment, pyridinium oximes-based AChE reactivators, antimuscarinic drugs and neuroprotective benzodiazepines for post-exposure treatment. These drugs ensure protection of peripheral nervous system and mitigate acute effects of OP lethal doses. However, they have significant limitations. Pyridostigmine and oximes do not protect/reactivate central AChE. Oximes poorly reactivate AChE inhibited by phosphoramidates. In addition, current neuroprotectants do not protect the central nervous system shortly after the onset of seizures when brain damage becomes irreversible. New therapeutic approaches for pre- and post-exposure treatments involve detoxification of OP molecules before they reach their molecular targets by administrating catalytic bioscavengers, among them phosphotriesterases are the most promising. Novel generation of broad spectrum reactivators are designed for crossing the blood-brain barrier and reactivate central AChE. This is an article for the special issue XVth International Symposium on Cholinergic Mechanisms.
[Mh] Termos MeSH primário: Acetilcolinesterase/metabolismo
Barreira Hematoencefálica/efeitos dos fármacos
Inibidores da Colinesterase/farmacologia
Reativadores da Colinesterase/metabolismo
Fármacos Neuroprotetores/farmacologia
Intoxicação por Organofosfatos/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Barreira Hematoencefálica/metabolismo
Reativadores da Colinesterase/farmacologia
Seres Humanos
Intoxicação por Organofosfatos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cholinesterase Inhibitors); 0 (Cholinesterase Reactivators); 0 (Neuroprotective Agents); EC 3.1.1.7 (Acetylcholinesterase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1111/jnc.14026


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[PMID]:28376842
[Au] Autor:Adinew GM; Asrie AB; Birru EM
[Ad] Endereço:Department of Pharmacology, School of Pharmacy, College of Medicine and Health Science, University of Gondar, P. O. Box: 196, Gondar, Ethiopia. getnet.mequanint@yahoo.com.
[Ti] Título:Pattern of acute organophosphorus poisoning at University of Gondar Teaching Hospital, Northwest Ethiopia.
[So] Source:BMC Res Notes;10(1):149, 2017 Apr 04.
[Is] ISSN:1756-0500
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Despite the apparent benefits of organophosphate compounds (OPCs) acute organophosphate (OP) pesticide poison is an increasing problem worldwide. In a country like Ethiopia, where agriculture is a major component of the economy, these compounds are readily available to the general public. There is paucity of evidence from Ethiopia showing the pattern of organophosphate poisoning (OPP) in healthcare facilities. The objective of this study was to evaluate retrospectively the pattern of acute OPP at the University of Gondar Teaching Hospital in northwest Ethiopia, during September 2010 through December 2014 was conducted. Data was collected through chart review of patients who were admitted due to poisoning. Data was analysed using SPSS 20. RESULTS: Organophosphate poisoning in University of Gondar teaching hospital accounts for about 38.46% of all emergency room admissions for poisoning. Out of the 90 cases studied 60% (54) were women, with male to female ratio of 1:1.5. The mean age of the patients was 25.5 with a standard deviation of 9.45. 56.7% of the cases studies lived in an urban environment compared to 43.3% who lived rurally. In the vast majority of patients, 90% (81) patients had ingested OP as an act of suicide. Regarding the route of exposure, oral ingestion was most common in suicidal cases (88.9%). The elapsed time between the time of poison ingestion and the start of the treatment, ranged from 13 min to 1 day. Health care professionals' useds decontamination methods such as gastric lavage and activated charcoal (45.6%) and 36.7% use atropine for OPP treatment. The mean hospital stay was 0.74 days. In the present study family problems were a leading cause of suicides and accounted for 45.8% of all cases. CONCLUSION: As a developing nation who economy relies heavily on agriculture, Ethiopia continues to have OP compounds remain a common cause of acute poisonings. This is particularly concerning for younger generation who have high rates of OPP and whose numbers continue to raise. This data suggests that it is essential to strengthen Ethiopians regulatory policy concerning the availability of OPCs. Additionally, it will be important to design an appropriate health education program for the prevention of both suicidal and accidental OPPs for the benefit of the public at large.
[Mh] Termos MeSH primário: Serviço Hospitalar de Emergência/estatística & dados numéricos
Hospitais de Ensino/estatística & dados numéricos
Intoxicação por Organofosfatos/terapia
[Mh] Termos MeSH secundário: Doença Aguda
Adolescente
Adulto
Atropina/uso terapêutico
Broncodilatadores/uso terapêutico
Carvão Vegetal/uso terapêutico
Criança
Etiópia
Feminino
Lavagem Gástrica/métodos
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Fatores de Risco
População Rural/estatística & dados numéricos
Tentativa de Suicídio/estatística & dados numéricos
Inquéritos e Questionários
População Urbana/estatística & dados numéricos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bronchodilator Agents); 16291-96-6 (Charcoal); 7C0697DR9I (Atropine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1186/s13104-017-2464-5


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[PMID]:28296779
[Au] Autor:Bao HX; Tong PJ; Li CX; Du J; Chen BY; Huang ZH; Wang Y
[Ad] Endereço:aFirst Clinical Medical College of Zhejiang Chinese Medical University bZhejiang Provincial Hospital of TCM cDepartment of Laboratory Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College dDepartment of Transfusion, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou eInstitute of Neuroscience and Institute of Hypoxia Medicine, Wenzhou Medical University, Wenzhou fDepartment of Transfusion, Lishui People's Hospital, Lishui, Zhejiang, China.
[Ti] Título:Efficacy of fresh packed red blood transfusion in organophosphate poisoning.
[So] Source:Medicine (Baltimore);96(11):e6375, 2017 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The mortality rate caused by organophosphate (OP) poisoning is still high, even the standard treatment such as atropine and oxime improves a lot. To search for alternative therapies, this study was aimed to investigate the effects of packed red blood cell (RBC) transfusion in acute OP poisoning, and compare the therapeutic effects of RBCs at different storage times.Patients diagnosed with OP poisoning were included in this prospective study. Fresh RBCs (packed RBCs stored less than 10 days) and longer-storage RBCs (stored more than 10 days but less than 35 days) were randomly transfused or not into OP poisoning patients. Cholinesterase (ChE) levels in blood, atropine usage and durations, pralidoxime durations were measured.We found that both fresh and longer-storage RBCs (200-400 mL) significantly increased blood ChE levels 6 hours after transfusion, shortened the duration for ChE recovery and length of hospital stay, and reduced the usage of atropine and pralidoxime. In addition, fresh RBCs demonstrated stronger therapeutic effects than longer-storage RBCs.Packed RBCs might be an alternative approach in patients with OP poisoning, especially during early stages.
[Mh] Termos MeSH primário: Transfusão de Eritrócitos/métodos
Intoxicação por Organofosfatos/terapia
[Mh] Termos MeSH secundário: Doença Aguda
Atropina/uso terapêutico
Reativadores da Colinesterase/uso terapêutico
Colinesterases/sangue
Feminino
Lavagem Gástrica
Seres Humanos
Masculino
Intoxicação por Organofosfatos/tratamento farmacológico
Compostos de Pralidoxima/uso terapêutico
Estudos Prospectivos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Cholinesterase Reactivators); 0 (Pralidoxime Compounds); 7C0697DR9I (Atropine); EC 3.1.1.8 (Cholinesterases); P7MU9UTP52 (pralidoxime)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170410
[Lr] Data última revisão:
170410
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006375


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[PMID]:28259020
[Au] Autor:Rathod AL; Garg RK
[Ad] Endereço:Dept. of Forensic Science, Punjabi University, Patiala, 147002, India. Electronic address: ankushrathod80@gmail.com.
[Ti] Título:Chlorpyrifos poisoning and its implications in human fatal cases: A forensic perspective with reference to Indian scenario.
[So] Source:J Forensic Leg Med;47:29-34, 2017 04.
[Is] ISSN:1878-7487
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Clorpirifos/toxicidade
Intoxicação por Organofosfatos
[Mh] Termos MeSH secundário: Acidentes
Biotransformação
Clorpirifos/química
Clorpirifos/farmacocinética
Exposição Ambiental/efeitos adversos
Toxicologia Forense
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Índia
Intoxicação por Organofosfatos/diagnóstico
Extração em Fase Sólida
Suicídio
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
JCS58I644W (Chlorpyrifos)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE


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[PMID]:28258856
[Au] Autor:Deng J; Lu D; Zhang X; Shi G; Zhou T
[Ad] Endereço:School of Ecological and Environmental Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China.
[Ti] Título:Highly sensitive GQDs-MnO based assay with turn-on fluorescence for monitoring cerebrospinal acetylcholinesterase fluctuation: A biomarker for organophosphorus pesticides poisoning and management.
[So] Source:Environ Pollut;224:436-444, 2017 May.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, we demonstrated an assay with turn-on fluorescence for monitoring cerebrospinal acetylcholinesterase (AChE) fluctuation as a biomarker for organophosphorus pesticides (OPs) poisoning and management based on single layer MnO nanosheets with graphene quantum dots (GQDs) as signal readout. Initially, the fluorescence of GQDs was quenched by MnO nanosheets mainly due to the inner filter effect (IFE). However, with the presence of reductive thiocholine (TCh), the enzymatic product, hydrolyzed from acetylthiocholine (ATCh) by AChE, the redox reaction between MnO and TCh occurred, leading to the destruction of the MnO nanosheets, and thereby IFE was diminished gradually. As a consequence, the turn-on fluorescence of GQDs with the changes in the spectrum of the dispersion constituted a new mechanism for sensing of cerebrospinal AChE. With the method developed here, we could monitor cerebrospinal AChE fluctuation of rats exposed to OPs before and after therapy, and could thereby open up the pathway to a new sensing platform for better understanding the mechanism of brain dysfunctions associate with OPs poisoning.
[Mh] Termos MeSH primário: Acetilcolinesterase/líquido cefalorraquidiano
Grafite/química
Compostos de Manganês/química
Intoxicação por Organofosfatos/líquido cefalorraquidiano
Óxidos/química
Pontos Quânticos/química
[Mh] Termos MeSH secundário: Animais
Bioensaio
Biomarcadores/líquido cefalorraquidiano
Masculino
Nanoconchas/química
Intoxicação por Organofosfatos/terapia
Praguicidas/envenenamento
Ratos
Ratos Sprague-Dawley
Sensibilidade e Especificidade
Espectrometria de Fluorescência/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Manganese Compounds); 0 (Oxides); 0 (Pesticides); 7782-42-5 (Graphite); EC 3.1.1.7 (Acetylcholinesterase); TF219GU161 (manganese dioxide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170524
[Lr] Data última revisão:
170524
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE


  10 / 1459 MEDLINE  
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Brito, Ana María
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[PMID]:28002976
[Au] Autor:Muñoz-Quezada MT; Lucero B; Iglesias V; Levy K; Muñoz MP; Achú E; Cornejo C; Concha C; Brito AM; Villalobos M
[Ad] Endereço:a Faculty of Health Sciences , Universidad Católica del Maule , Talca , Chile.
[Ti] Título:Exposure to organophosphate (OP) pesticides and health conditions in agricultural and non-agricultural workers from Maule, Chile.
[So] Source:Int J Environ Health Res;27(1):82-93, 2017 Feb.
[Is] ISSN:1369-1619
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The objective was to evaluate the characteristics of exposure to OP pesticides and health status in Chilean farm workers from the Maule Region. An occupational health questionnaire was administered in 207 agricultural and non-agricultural workers. For the group of agricultural workers, we asked about specific occupational exposure history and symptoms of OP pesticide poisoning. The main health problem of the exposed group was previous OP pesticide poisoning (p < 0.001). Fifty-six percent of agricultural workers reported symptoms consistent with acute OP pesticide poisoning. The use of respiratory personal protective equipment and younger age were protective against these symptoms, and number of years of OP pesticide exposure was positively associated with reporting symptoms of poisoning. Of the pesticide applicators 47 % reported using chlorpyrifos. The regulations regarding use and application of pesticides should be strengthened, as should training and intervention with workers to improve the use of personal protective equipment.
[Mh] Termos MeSH primário: Exposição Ocupacional
Intoxicação por Organofosfatos/epidemiologia
Praguicidas/envenenamento
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Chile
Fazendeiros
Feminino
Seres Humanos
Masculino
Meia-Idade
Saúde do Trabalhador/estatística & dados numéricos
Intoxicação por Organofosfatos/etiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pesticides)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161223
[St] Status:MEDLINE
[do] DOI:10.1080/09603123.2016.1268679



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