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[PMID]:29465560
[Au] Autor:Xue X; Song Y; Yu X; Fan Q; Tang J; Chen X
[Ad] Endereço:Department of Substance Abuse, Qingdao Mental Health Center, Qingdao.
[Ti] Título:Olanzapine and haloperidol for the treatment of acute symptoms of mental disorders induced by amphetamine-type stimulants: A randomized controlled trial.
[So] Source:Medicine (Baltimore);97(8):e9786, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study aimed to compare olanzapine and haloperidol efficacies in the treatment of acute psychiatric symptoms due to amphetamine-type stimulants (ATSs). METHODS: The Zelen II design method was used; 124 patients with acute mental disorders due to amphetamine were randomly divided into olanzapine group (n = 63) and haloperidol group (n = 61). Then, a 4-week open-label medical therapy was performed. Clinical Global Impression Scale Item 2 was employed to evaluate the onset time; meanwhile, Brief Psychiatric Rating Scale (BPRS) was used at baseline and at posttreatment weeks 1, 2, and 4. Moreover, adverse reactions during the treatment were recorded. RESULTS: Onset time in the olanzapine group was significantly earlier than in the haloperidol group; BPRS scores in the olanzapine group were significantly lower than haloperidol group values at 1 and 2 weeks of treatment. The overall effective rates had no statistically significant difference. CONCLUSION: Short-term olanzapine and haloperidol treatments had equivalent efficacies in the treatment of acute symptoms of mental disorders due to ATSs; however, olanzapine administration resulted in relatively earlier disease onset, with less adverse reactions.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Anfetaminas/tratamento farmacológico
Antipsicóticos/administração & dosagem
Benzodiazepinas/administração & dosagem
Haloperidol/administração & dosagem
Transtornos Mentais/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Anfetamina/efeitos adversos
Transtornos Relacionados ao Uso de Anfetaminas/psicologia
Escalas de Graduação Psiquiátrica Breve
Estimulantes do Sistema Nervoso Central/efeitos adversos
Feminino
Seres Humanos
Masculino
Transtornos Mentais/induzido quimicamente
Projetos de Pesquisa
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antipsychotic Agents); 0 (Central Nervous System Stimulants); 12794-10-4 (Benzodiazepines); CK833KGX7E (Amphetamine); J6292F8L3D (Haloperidol); N7U69T4SZR (olanzapine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009786


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[PMID]:27776672
[Au] Autor:Hellem TL
[Ad] Endereço:Montana State University College of Nursing, Missoula, MT 59812-7416, United States. Electronic address: tracy.hellem1@montana.edu.
[Ti] Título:A Review of Methamphetamine Dependence and Withdrawal Treatment: A Focus on Anxiety Outcomes.
[So] Source:J Subst Abuse Treat;71:16-22, 2016 12.
[Is] ISSN:1873-6483
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rates of anxiety disorders among individuals who use methamphetamine are estimated to be as high as 30.2%. The presence of an anxiety disorder in methamphetamine users is associated with higher rates of relapse, non-adherence to treatment and poorer outcomes relative to methamphetamine users without an anxiety disorder. A review investigating current treatment options for methamphetamine dependence or withdrawal from methamphetamine was conducted using PubMed, CINAHL and PsycINFO. The focus of the review was trials that utilized an intervention and collected anxiety as an outcome measure. Seven studies were included in the review, and five of these studies examined a pharmacotherapy option, one studied a psychosocial intervention and one study investigated exercise as an intervention. Some of the pharmacotherapy studies and the study of exercise were associated with improvements in mood and/or a reduction in methamphetamine use. Concerns of sample size and measurement of anxiety were raised. Future well-designed research with large sample sizes is warranted to examine how to manage anxiety among methamphetamine users.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Anfetaminas/terapia
Transtornos de Ansiedade
Estimulantes do Sistema Nervoso Central
Metanfetamina
Avaliação de Resultados (Cuidados de Saúde)
Síndrome de Abstinência a Substâncias/terapia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Central Nervous System Stimulants); 44RAL3456C (Methamphetamine)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:28448903
[Au] Autor:Argento E; Strathdee SA; Goldenberg S; Braschel M; Montaner J; Shannon K
[Ad] Endereço:Gender and Sexual Health Initiative, BC Centre for Excellence in HIV/AIDS, St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada; Interdisciplinary Studies Graduate Program, University of British Columbia, 2357 Main Mall, Vancouver, BC, V6T 1Z4, Canada.
[Ti] Título:Violence, trauma and living with HIV: Longitudinal predictors of initiating crystal methamphetamine injection among sex workers.
[So] Source:Drug Alcohol Depend;175:198-204, 2017 06 01.
[Is] ISSN:1879-0046
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Despite rapid increases in crystal methamphetamine (CM) use worldwide and established gendered patterns of use, empirical research on CM injection initiation among sex workers is limited. Given the wide range of harms associated with CM, alongside stimulant effects including sexual dis-inhibition and prolonged awake-ness, this study aimed to longitudinally investigate socio-structural predictors of initiating CM injection among sex workers in Vancouver, Canada. METHODS: Data (2010-2014) were drawn from a community-based cohort of women sex workers: AESHA (An Evaluation of Sex Workers Health Access). Participants completed bi-annual interviewer-administered questionnaires and HIV/STI testing. Kaplan Meier methods and Cox proportional hazards regression were used to model predictors of CM injection initiation among CM injection-naïve participants. RESULTS: Of 455 participants eligible at baseline, 14.3% (n=65) injected CM for the first time over follow-up, with an incidence density of 6.79 per 100 person-years (95% Confidence Interval [CI] 5.30-8.69). In multivariable analysis, injection heroin use (Adjusted Hazard Ratio [AHR] 6.11; 95%CI 3.24-11.52), having an intimate partner who injects drugs (AHR 2.93; 95%CI 1.57-5.46), workplace violence (AHR 2.85; 95%CI 1.74-4.67), HIV seropositivity (AHR 2.69; 95%CI 1.45-5.00), and childhood abuse (AHR 1.86; 95%CI 0.99-3.49) were independently associated with initiating CM injection. CONCLUSIONS: Findings underscore the gendered and social risk environment of CM injection initiation among sex workers. The strong influences of historical/workplace violence, coupled with heroin injection (known to be self-medicating for post-traumatic stress) as a primary risk pathway, emphasize the urgency of increasing access to integrated, trauma-informed addiction treatment and HIV care for marginalized women.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Anfetaminas/psicologia
Infecções por HIV/psicologia
Profissionais do Sexo/psicologia
Abuso de Substâncias por Via Intravenosa/psicologia
Violência/psicologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Colúmbia Britânica
Estudos de Coortes
Feminino
Seres Humanos
Incidência
Injeções/psicologia
Estudos Longitudinais
Metanfetamina/administração & dosagem
Modelos de Riscos Proporcionais
Comportamento Sexual/psicologia
Parceiros Sexuais/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
44RAL3456C (Methamphetamine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE


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[PMID]:28700012
[Au] Autor:Massaro LTS; Abdalla RR; Laranjeira R; Caetano R; Pinsky I; Madruga CS
[Ad] Endereço:Instituto Nacional de Ciência e Tecnologia para Políticas Públicas do Álcool e Outras Drogas (INPAD), São Paulo, SP, Brazil.
[Ti] Título:Amphetamine-type stimulant use and conditional paths of consumption: data from the Second Brazilian National Alcohol and Drugs Survey.
[So] Source:Rev Bras Psiquiatr;39(3):201-207, 2017 Jul-Sep.
[Is] ISSN:1809-452X
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Objective:: The aim of this study was to estimate nationally representative prevalence rates of amphetamine-type stimulant (ATS) use and to identify consumption-associated factors, proposing a conditional model of direct and indirect consumption paths. Method:: Using data from the Second Brazilian National Alcohol and Drugs Survey, this cross-sectional study analyzed a subsample of 3,828 participants between 15 and 64 years old, gathering information on the use of psychoactive substances in a probabilistic sample of the Brazilian household population. Results:: Rates of lifetime and last-year ATS use were, respectively, 4.1 and 1.6%. Economically privileged individuals and users of other substances were more at risk for using ATS. The results suggest that higher education decreases the chances of ATS consumption. The conditional model showed that higher income increased ATS use, higher education lowered the odds of such an increase, and cocaine use cancelled that associative effect. Conclusion:: Brazil presents high rates of ATS use. Prevention and treatment strategies should focus on the protective effect of higher education levels and should target polydrug use. Knowledge of ATS-associated factors and user profiles is the starting point for developing effective treatments and tailored prevention strategies.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Anfetaminas/epidemiologia
Inquéritos e Questionários
[Mh] Termos MeSH secundário: Adolescente
Adulto
Brasil/epidemiologia
Transtornos Relacionados ao Uso de Cocaína/epidemiologia
Estudos Transversais
Escolaridade
Feminino
Seres Humanos
Renda/estatística & dados numéricos
Masculino
Meia-Idade
Prevalência
Distribuição por Sexo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE


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[PMID]:28630283
[Au] Autor:Moszczynska A; Callan SP
[Ad] Endereço:Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan amosz@wayne.edu.
[Ti] Título:Molecular, Behavioral, and Physiological Consequences of Methamphetamine Neurotoxicity: Implications for Treatment.
[So] Source:J Pharmacol Exp Ther;362(3):474-488, 2017 Sep.
[Is] ISSN:1521-0103
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Understanding the relationship between the molecular mechanisms underlying neurotoxicity of high-dose methamphetamine (METH) and related clinical manifestations is imperative for providing more effective treatments for human METH users. This article provides an overview of clinical manifestations of METH neurotoxicity to the central nervous system and neurobiology underlying the consequences of administration of neurotoxic METH doses, and discusses implications of METH neurotoxicity for treatment of human abusers of the drug.
[Mh] Termos MeSH primário: Metanfetamina/toxicidade
Síndromes Neurotóxicas/complicações
[Mh] Termos MeSH secundário: Transtornos Relacionados ao Uso de Anfetaminas/tratamento farmacológico
Animais
Disfunção Cognitiva/induzido quimicamente
Disfunção Cognitiva/tratamento farmacológico
Neurônios Dopaminérgicos/efeitos dos fármacos
Relação Dose-Resposta a Droga
Seres Humanos
Metanfetamina/farmacologia
Vias Neurais/efeitos dos fármacos
Síndromes Neurotóxicas/tratamento farmacológico
Neurônios Serotoninérgicos/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
44RAL3456C (Methamphetamine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1124/jpet.116.238501


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[PMID]:28434182
[Au] Autor:Wilkins C; Prasad J; Parker K; Rychert M; Barnes HM
[Ad] Endereço:SHORE and Whariki Research Centre, College of Health, Massey University, Auckland, New Zealand. C.Wilkins@massey.ac.nz.
[Ti] Título:Recent Trends in Alcohol and Other Drug Use Among Police Detainees in New Zealand, 2010-2015.
[So] Source:Curr Top Behav Neurosci;34:161-172, 2017.
[Is] ISSN:1866-3370
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: New Zealand has unusual patterns of recreational substance use by international standards including low levels of cocaine and heroin use, and high methamphetamine use. AIMS: This paper examines recent trends in alcohol and other drug use among police detainees in New Zealand over the past six years. METHOD: The paper utilises data from the New Zealand Arrestee Drug Use Monitoring (NZ-ADUM) study. NZ-ADUM interviewed approximately 800 police detainees each year at four central city police watch houses (i.e. Whangarei, Auckland, Wellington, Christchurch) from 2010 to 2015. RESULTS: The proportion of police detainees who had used methamphetamine in the previous year increased from 28% in 2012 to 36% in 2015. Drinking prior to arrest declined from 41% in 2013 to 28% in 2015. The use of cannabis in the past year declined slightly from 76% in 2011 to 69% in 2015. The proportion using ecstasy in the previous year steadily declined from 28% in 2011 to 19% in 2015. Only small minorities had recently used cocaine or an opioid. Use of methamphetamine and ecstasy increased in Christchurch. CONCLUSION: Growing methamphetamine use is consistent with record seizures of methamphetamine over the past 2-3 years. Increasing drug use in Christchurch may reflect factors related to the devastating earthquakes in 2011 and the subsequent city rebuild, including an influx of construction workers, more organised trafficking groups and earthquake-related stress. The decline in cannabis use may be related to the emergence of 'legal' synthetic cannabinoids. The decline in ecstasy use may be the result of recent domestic enforcement operations and the overall global shortage of MDMA. The decline in alcohol drinking may be due to the introduction of pre-charge formal warnings for minor alcohol and disorder offences, and new restrictions on alcohol premise opening hours. Acknowledgements: The New Zealand Drug Use Monitoring (NZ-ADUM) research study is funded by the New Zealand Police and is conducted by SHORE and Whariki Research Centre, College of Health at Massey University, Auckland. We would like to thank New Zealand Police staff at Whangarei, Auckland Central, Wellington Central and Christchurch Central police watch houses for their assistance and cooperation with this research. We would also like to thank all the interviewers who worked with us on NZ-ADUM and all the police detainees who agreed to be interviewed for the study. The views expressed in this paper are entirely our own and do not necessarily reflect those of New Zealand Police.
[Mh] Termos MeSH primário: Alcoolismo/epidemiologia
Transtornos Relacionados ao Uso de Anfetaminas/epidemiologia
Transtornos Relacionados ao Uso de Cocaína/epidemiologia
Fumar Maconha/epidemiologia
Transtornos Relacionados ao Uso de Opioides/epidemiologia
Prisioneiros/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Analgésicos Opioides
Cannabis
Cocaína
Feminino
Seres Humanos
Masculino
Metanfetamina
N-Metil-3,4-Metilenodioxianfetamina
Nova Zelândia/epidemiologia
Transtornos Relacionados ao Uso de Substâncias/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid); 44RAL3456C (Methamphetamine); I5Y540LHVR (Cocaine); KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170424
[St] Status:MEDLINE
[do] DOI:10.1007/7854_2016_471


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[PMID]:28422859
[Au] Autor:Zhang M; Lv D; Zhou W; Ji L; Zhou B; Chen H; Gu Y; Zhao J; He J
[Ad] Endereço:aDepartment of Clinical Laboratory bDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
[Ti] Título:The levels of triglyceride and total cholesterol in methamphetamine dependence.
[So] Source:Medicine (Baltimore);96(16):e6631, 2017 Apr.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The serum triglyceride (TG) and total cholesterol (TC) levels have been reported altered in the traditional drug-dependence (such as marijuana and heroin). However, studies assessing the relationships among serum TC, TG, and methamphetamine (MA)-dependence have not been described well. In this study, our aim is to explore the serum TG and TC levels in large sample of MA-dependent patients. A retrospective study was conducted in 938 MA-dependent patients who were recruited between February 2, 2008 and March 11, 2013, with social characteristics and drug-dependence history (duration of MA use, routes of drug administration, and daily dose were collected). Then, the serum levels of TC, TG, glucose (GLU), body mass index (BMI), and blood pressure were measured among the participants. Meanwhile, 985 age- and gender-matched healthy people in the physical examination center were selected as control group. Compared with the control group, significant decreases of TC, TG, GLU, and BMI were observed in MA-dependent patients (P < 0.05). Besides, we found that the daily dose of MA use was associated with TC (ß = -0.079, P = 0.015) and the duration of MA use was independently related to BMI (ß = -0.071, P = 0.031). This study demonstrated that the levels of TC, TG, GLU, and BMI factors altered in the MA-dependent patients. In addition, there is a negative association between MA dependence and TC and BMI.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Anfetaminas/sangue
Colesterol/sangue
Triglicerídeos/sangue
[Mh] Termos MeSH secundário: Adolescente
Adulto
Glicemia
Pressão Sanguínea
Índice de Massa Corporal
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Fatores Socioeconômicos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Triglycerides); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006631


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[PMID]:28403074
[Au] Autor:Su H; Zhang J; Ren W; Xie Y; Tao J; Zhang X; He J
[Ad] Endereço:aDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou bShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine cDepartment of Neurology, Zhongshan Hospital, Fudan University, Shanghai dDepartment of Neurology, The First Affiliated Hospital of Yangtze University, Jingzhou eSir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou fBeijing HuiLongGuan Hospital, Peking University, Beijing, China gDepartment of Psychiatry and Behavioral Sciences, Harris County Psychiatric Center, The University of Texas Health Science Center at Houston, Houston, TX.
[Ti] Título:Anxiety level and correlates in methamphetamine-dependent patients during acute withdrawal.
[So] Source:Medicine (Baltimore);96(15):e6434, 2017 Apr.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Anxiety is often a core element of withdrawal symptoms; however, risk factors associated with anxiety symptoms during the early stage of withdrawal in methamphetamine (METH) users are not well understood. Two hundred ten METH-dependent subjects who had been abstinent for 1 to 7 days were recruited. We used a set of self-administrative questionnaires eliciting information on sociodemographics, detailed drug use history and anxiety. Beck Anxiety Inventory (BAI) was used to measure anxiety symptoms. METH users had a mean BAI score of 6.9; 72 (34.3%) of the study sample had anxiety symptoms during acute METH withdrawal, including 42 (20.0%) with mild anxiety, 25 (11.9%) with moderate anxiety, and 5 (2.4%) with severe anxiety. In addition, gender (female), higher frequency of drug use, and history of polysubstance use were significantly correlated with anxiety symptoms during acute METH withdrawal. Anxiety symptoms appear to be common during the first week of METH abstinence, and several risk factors are identified.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Anfetaminas/psicologia
Ansiedade/induzido quimicamente
Estimulantes do Sistema Nervoso Central/efeitos adversos
Metanfetamina/efeitos adversos
Síndrome de Abstinência a Substâncias/psicologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Escalas de Graduação Psiquiátrica
Fatores de Risco
Fatores Sexuais
Inquéritos e Questionários
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Central Nervous System Stimulants); 44RAL3456C (Methamphetamine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170430
[Lr] Data última revisão:
170430
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006434


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[PMID]:28351169
[Au] Autor:Morley KC; Cornish JL; Faingold A; Wood K; Haber PS
[Ad] Endereço:a NHMRC Centre for Excellence in Mental Health and Substance Use, Discipline of Addiction Medicine , The University of Sydney , Sydney , Australia.
[Ti] Título:Pharmacotherapeutic agents in the treatment of methamphetamine dependence.
[So] Source:Expert Opin Investig Drugs;26(5):563-578, 2017 May.
[Is] ISSN:1744-7658
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Methamphetamine use is a serious public health concern in many countries and is second to cannabis as the most widely abused illicit drug in the world. Effective management for methamphetamine dependence remains elusive and the large majority of methamphetamine users relapse following treatment. Areas covered: Progression in the understanding of the pharmacological basis of methamphetamine use has provided us with innovative opportunities to develop agents to treat dependence. The current review summarizes relevant literature on the neurobiological and clinical correlates associated with methamphetamine use. We then outline agents that have been explored for potential treatments in preclinical studies, human laboratory phase I and phase II trials over the last ten years. Expert opinion: No agent has demonstrated a broad and strong effect in achieving MA abstinence in Phase II trials. Agents with novel therapeutic targets appear promising. Advancement in MA treatment, including translation into practice, faces several clinical challenges.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Anfetaminas/tratamento farmacológico
Desenho de Drogas
Metanfetamina/efeitos adversos
[Mh] Termos MeSH secundário: Transtornos Relacionados ao Uso de Anfetaminas/epidemiologia
Animais
Estimulantes do Sistema Nervoso Central/administração & dosagem
Estimulantes do Sistema Nervoso Central/efeitos adversos
Seres Humanos
Metanfetamina/administração & dosagem
Terapia de Alvo Molecular
Recidiva
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Central Nervous System Stimulants); 44RAL3456C (Methamphetamine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE
[do] DOI:10.1080/13543784.2017.1313229


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[PMID]:28319198
[Au] Autor:Uno K; Miyazaki T; Sodeyama K; Miyamoto Y; Nitta A
[Ad] Endereço:Department of Pharmaceutical Therapy and Neuropharmacology, Faculty of Pharmaceutical Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
[Ti] Título:Methamphetamine induces Shati/Nat8L expression in the mouse nucleus accumbens via CREB- and dopamine D1 receptor-dependent mechanism.
[So] Source:PLoS One;12(3):e0174196, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Shati/Nat8L significantly increased in the nucleus accumbens (NAc) of mice after repeated methamphetamine (METH) treatment. We reported that Shati/Nat8L overexpression in mouse NAc attenuated METH-induced hyperlocomotion, locomotor sensitization, and conditioned place preference. We recently found that Shati/Nat8L overexpression in NAc regulates the dopaminergic neuronal system via the activation of group II mGluRs by elevated N-acetylaspartylglutamate following N-acetylaspartate increase due to the overexpression. These findings suggest that Shati/Nat8L suppresses METH-induced responses. However, the mechanism by which METH increases the Shati/Nat8L mRNA expression in NAc is unclear. To investigate the regulatory mechanism of Shati/Nat8L mRNA expression, we performed a mouse Shati/Nat8L luciferase assay using PC12 cells. Next, we investigated the response of METH to Shati/Nat8L expression and CREB activity using mouse brain slices of NAc, METH administration to mice, and western blotting for CREB activity of specific dopamine receptor signals in vivo and ex vivo. We found that METH activates CREB binding to the Shati/Nat8L promoter to induce the Shati/Nat8L mRNA expression. Furthermore, the dopamine D1 receptor antagonist SCH23390, but not the dopamine D2 receptor antagonist sulpiride, inhibited the upregulation of Shati/Nat8L and CREB activities in the mouse NAc slices. Thus, the administration of the dopamine D1 receptor agonist SKF38393 increased the Shati/Nat8L mRNA expression in mouse NAc. These results showed that the Shati/Nat8L mRNA was increased by METH-induced CREB pathway via dopamine D1 receptor signaling in mouse NAc. These findings may contribute to development of a clinical tool for METH addiction.
[Mh] Termos MeSH primário: Acetiltransferases/metabolismo
Estimulantes do Sistema Nervoso Central/farmacologia
Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/metabolismo
Metanfetamina/farmacologia
Núcleo Accumbens/efeitos dos fármacos
Receptores de Dopamina D1/metabolismo
[Mh] Termos MeSH secundário: Acetiltransferases/genética
Transtornos Relacionados ao Uso de Anfetaminas/metabolismo
Animais
Condicionamento (Psicologia)/efeitos dos fármacos
Condicionamento (Psicologia)/fisiologia
Dopaminérgicos/farmacologia
Expressão Gênica/efeitos dos fármacos
Masculino
Camundongos Endogâmicos C57BL
Atividade Motora/efeitos dos fármacos
Atividade Motora/fisiologia
Núcleo Accumbens/metabolismo
Células PC12
Regiões Promotoras Genéticas
RNA Mensageiro/metabolismo
Ratos
Receptores de Dopamina D2/metabolismo
Comportamento Espacial/efeitos dos fármacos
Comportamento Espacial/fisiologia
Técnicas de Cultura de Tecidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Central Nervous System Stimulants); 0 (Creb1 protein, mouse); 0 (Cyclic AMP Response Element-Binding Protein); 0 (DRD2 protein, mouse); 0 (Dopamine Agents); 0 (RNA, Messenger); 0 (Receptors, Dopamine D1); 0 (Receptors, Dopamine D2); 44RAL3456C (Methamphetamine); EC 2.3.1.- (Acetyltransferases); EC 2.3.1.- (Shati protein, mouse)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174196



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