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Lemos, Tadeu
Texto completo SciELO Brasil
[PMID]:29267663
[Au] Autor:Sordi MB; Massochin RC; Camargo AR; Lemos T; Munhoz EA
[Ad] Endereço:Universidade Federal de Santa Catarina - UFSC, Health Science Centre, Department of Stomatology, Florianópolis, SC, Brazil.
[Ti] Título:Oral health assessment for users of marijuana and cocaine/crack substances.
[So] Source:Braz Oral Res;31:e102, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to assess the oral health status of users of illicit drugs such as marijuana and cocaine/crack and compare it with individuals not using these chemical substances. Questionnaires were applied to 35 illicit drugs users to gather information on demographic status, general health, and use of drugs. Then, a clinical assessment of the oral health condition was performed to collect data on decayed, missing and filled teeth (DMFT) index, salivary flow rate (SFR), and mucosal lesions. The control group was composed of 35 non-illicit drug users. In the experimental group, 91.43% were males, 80% were smokers, and 42.85% were alcoholics. Cocaine was the most common drug used (77.15%), followed by marijuana (68.6%), and crack (51.4%). The average DMFT index was 9.8 and the SFR was reduced in 60% of subjects. Mucosal alterations were detected, but no potentially malignant disorders or oral cancer were diagnosed. Compared to control group, significantly higher values for gender (40%, p = 0.0001), smoking (22.86%) and heavy drinking (5.7%) habits (p = 0.0001), SFR (31.4%; p = 0.0308), and oral lesions (p = 0.0488) were found for the experimental group, although significantly higher values were found in the control group for DMFT index (p = 0.0148). It can be concluded that the use of illicit drugs contributed to an increased prevalence of oral mucosa lesions. In addition, a decline on SFR and a reduced DMFT index was observed for illicit drug users.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Cocaína/complicações
Abuso de Maconha/complicações
Doenças da Boca/induzido quimicamente
Mucosa Bucal/efeitos dos fármacos
Saúde Bucal/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Alcoolismo/complicações
Alcoolismo/epidemiologia
Estudos de Casos e Controles
Transtornos Relacionados ao Uso de Cocaína/epidemiologia
Estudos Transversais
Índice CPO
Feminino
Seres Humanos
Masculino
Abuso de Maconha/epidemiologia
Meia-Idade
Doenças da Boca/epidemiologia
Fatores de Risco
Salivação/efeitos dos fármacos
Taxa Secretória/efeitos dos fármacos
Distribuição por Sexo
Fumar/efeitos adversos
Fumar/epidemiologia
Fatores Socioeconômicos
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


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Laranjeira, Ronaldo R
Registro de Ensaios Clínicos
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[PMID]:29251975
[Au] Autor:Miguel AQC; Madruga CS; Cogo-Moreira H; Yamauchi R; Simões V; Ribeiro A; da Silva CJ; Fruci A; McDonell M; McPherson S; Roll JM; Laranjeira RR
[Ad] Endereço:National Institute of Policies on Alcohol and Drugs (INPAD).
[Ti] Título:Contingency management targeting abstinence is effective in reducing depressive and anxiety symptoms among crack cocaine-dependent individuals.
[So] Source:Exp Clin Psychopharmacol;25(6):466-472, 2017 12.
[Is] ISSN:1936-2293
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although contingency management (CM) is effective in promoting abstinence and treatment retention among crack cocaine users who meet the criteria for cocaine dependence, less is known about its off-target effects. In this secondary analysis, we evaluated the impact of CM on depressive and anxiety symptoms in a sample of cocaine-dependent individuals under treatment. Sixty-five crack cocaine users who met the criteria for cocaine dependence were randomly assigned to receive 12 weeks of standard treatment alone (STA; n = 32) or 12 weeks of standard treatment plus CM (STCM; n = 33). The outcome measures of the secondary analysis were depressive and anxiety symptoms assessed with the Beck Depression Inventory-II (BDI-II) and the Beck Anxiety Inventory (BAI). At baseline, 59 (90.8%) of the participants reported at least mild depressive symptoms and 47 (72.5%) reported at least mild anxiety symptoms. The mean BDI-II (24.5 ± 12.1) and BAI (20.7 ± 13.5) scores in the sample as a whole was moderate. After treatment, the reported levels of depressive symptoms (ß = -9.6, p < .05) and anxiety symptoms (ß = -9.9, p < .05) were lower among the individuals receiving STCM than among those receiving STA. This study provides evidence that an STCM intervention targeting crack cocaine abstinence also produces significant reductions in depressive and anxiety symptoms. This low cost intervention also demonstrated significant promise and optimization potential for crack cocaine users in a setting of scarce resources and high mental health comorbidity. Relevance Statement: We found that the prevalence of depressive and anxiety symptoms were extremely high among crack cocaine users, and that, among such individuals, contingency management (CM) reduced depressive and anxiety symptomatology to a greater degree than did standard treatment. Our results suggest that CM targeting crack cocaine abuse can have off-target effects on psychiatric symptomatology. (PsycINFO Database Record
[Mh] Termos MeSH primário: Ansiedade/etiologia
Transtornos Relacionados ao Uso de Cocaína/complicações
Cocaína Crack
Depressão/etiologia
Psicoterapia de Grupo/métodos
Reforço (Psicologia)
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Escalas de Graduação Psiquiátrica
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Crack Cocaine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180224
[Lr] Data última revisão:
180224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1037/pha0000147


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[PMID]:29339724
[Au] Autor:Calipari ES; Godino A; Peck EG; Salery M; Mervosh NL; Landry JA; Russo SJ; Hurd YL; Nestler EJ; Kiraly DD
[Ad] Endereço:Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[Ti] Título:Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine.
[So] Source:Nat Commun;9(1):9, 2018 01 16.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cocaine addiction is characterized by dysfunction in reward-related brain circuits, leading to maladaptive motivation to seek and take the drug. There are currently no clinically available pharmacotherapies to treat cocaine addiction. Through a broad screen of innate immune mediators, we identify granulocyte-colony stimulating factor (G-CSF) as a potent mediator of cocaine-induced adaptations. Here we report that G-CSF potentiates cocaine-induced increases in neural activity in the nucleus accumbens (NAc) and prefrontal cortex. In addition, G-CSF injections potentiate cocaine place preference and enhance motivation to self-administer cocaine, while not affecting responses to natural rewards. Infusion of G-CSF neutralizing antibody into NAc blocks the ability of G-CSF to modulate cocaine's behavioral effects, providing a direct link between central G-CSF action in NAc and cocaine reward. These results demonstrate that manipulating G-CSF is sufficient to alter the motivation for cocaine, but not natural rewards, providing a pharmacotherapeutic avenue to manipulate addictive behaviors without abuse potential.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos dos fármacos
Transtornos Relacionados ao Uso de Cocaína/tratamento farmacológico
Cocaína/farmacologia
Fator Estimulador de Colônias de Granulócitos/metabolismo
Plasticidade Neuronal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Comportamento Aditivo/tratamento farmacológico
Comportamento Aditivo/fisiopatologia
Cocaína/administração & dosagem
Transtornos Relacionados ao Uso de Cocaína/fisiopatologia
Condicionamento Operante
Fator Estimulador de Colônias de Granulócitos/administração & dosagem
Fator Estimulador de Colônias de Granulócitos/efeitos dos fármacos
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Núcleo Accumbens/efeitos dos fármacos
Núcleo Accumbens/metabolismo
Ratos
Ratos Sprague-Dawley
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
143011-72-7 (Granulocyte Colony-Stimulating Factor); I5Y540LHVR (Cocaine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-01881-x


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[PMID]:27776677
[Au] Autor:Jarlais DC; Arasteh K; Feelemyer J; McKnight C; Barnes DM; Tross S; Perlman DC; Campbell AN; Cooper HL; Hagan H
[Ad] Endereço:Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: ddesjarlais@chpnet.org.
[Ti] Título:From Long-Term Injecting to Long-Term Non-Injecting Heroin and Cocaine Use: The Persistence of Changed Drug Habits.
[So] Source:J Subst Abuse Treat;71:48-53, 2016 12.
[Is] ISSN:1873-6483
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Transitioning from injecting to non-injecting routes of drug administration can provide important individual and community health benefits. We assessed characteristics of persons who had ceased injecting while continuing to use heroin and/or cocaine in New York City. METHODS: We recruited subjects entering Mount Sinai Beth Israel detoxification and methadone maintenance programs between 2011 and 2015. Demographic information, drug use histories, sexual behaviors, and "reverse transitions" from injecting to non-injecting drug use were assessed in structured face-to-face interviews. There were 303 "former injectors," operationally defined as persons who had injected at some time in their lives, but had not injected in at least the previous 6 months. Serum samples were collected for HIV and HCV testing. RESULTS: Former injectors were 81% male, 19% female, 17% White, 43% African-American, and 38% Latino/a, with a mean age of 50 (SD=9.2), and were currently using heroin and/or cocaine. They had injected drugs for a mean of 14 (SD=12.2) years before ceasing injection, and a mean of 13 (SD=12) years had elapsed since their last injection. HIV prevalence among the sample was 13% and HCV prevalence was 66%. The former injectors reported a wide variety of reasons for ceasing injecting. Half of the group appeared to have reached a point where relapse back to injecting was no longer problematic: they had not injected for three or more years, were not deliberately using specific techniques to avoid relapse to injecting, and were not worried about relapsing to injecting. CONCLUSIONS: Former injectors report very-long term behavior change toward reduced individual and societal harm while continuing to use heroin and cocaine. The behavior change appears to be self-sustaining, with full replacement of an injecting route of drug administration by a non-injecting route of administration. Additional research on the process of long-term cessation of injecting should be conducted within a "combined prevention and care" approach to HIV and HCV infection among persons who use drugs.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Cocaína/epidemiologia
Dependência de Heroína/epidemiologia
Comportamento de Redução do Risco
Abuso de Substâncias por Via Intravenosa/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Cidade de Nova Iorque/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:29393308
[Au] Autor:Farrell CM; Cucu DF
[Ad] Endereço:Resident Physician, Northwestern University.
[Ti] Título:Cocaine-Related Acute Spinal Cord Infarction.
[So] Source:R I Med J (2013);101(1):28-29, 2018 Feb 02.
[Is] ISSN:2327-2228
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We report a rare case of anterior spinal artery syndrome in the setting of acute cocaine use. A 31-year-old man presented to the hospital unarousable with leukocytosis and a positive toxicology screen for opioids, cocaine, benzodiazepines and cannabis. He was placed on intravenous naloxone. As the patient regained consciousness, he was found to have paraplegia, sensory loss below the level of T5, and urinary retention. MRI findings showed a signal intensity abnormality from the level of T1-4, highly suggestive of an acute ischemic spinal cord infarct. [Full article available at http://rimed.org/rimedicaljournal-2018-02.asp].
[Mh] Termos MeSH primário: Síndrome da Artéria Espinal Anterior/induzido quimicamente
Transtornos Relacionados ao Uso de Cocaína/complicações
Cocaína/toxicidade
Drogas Ilícitas/toxicidade
[Mh] Termos MeSH secundário: Adulto
Síndrome da Artéria Espinal Anterior/diagnóstico por imagem
Seres Humanos
Imagem por Ressonância Magnética
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Street Drugs); I5Y540LHVR (Cocaine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE


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[PMID]:28455489
[Au] Autor:Zhang F; Tongo ND; Hastings V; Kanzali P; Zhu Z; Chadow H; Rafii SE
[Ad] Endereço:Department of Internal Medicine, Brookdale University Hospital and Medical Center, Brooklyn, NY, USA.
[Ti] Título:ST-Segment Elevation Myocardial Infarction with Acute Stent Thrombosis Presenting as Intractable Hiccups: An Unusual Case.
[So] Source:Am J Case Rep;18:467-471, 2017 Apr 29.
[Is] ISSN:1941-5923
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Acute coronary syndrome (ACS) can present with atypical chest pain or symptoms not attributed to heart disease, such as indigestion. Hiccups, a benign and self-limited condition, can become persistent or intractable with overlooked underlying etiology. There are various causes of protracted hiccups, including metabolic abnormalities, psychogenic disorders, malignancy, central nervous system pathology, medications, pulmonary disorders, or gastrointestinal etiologies. It is rarely attributed to cardiac disease. CASE REPORT We report a case of intractable hiccups in a 51-year-old male with cocaine related myocardial infarction (MI) before and after stent placement. Coronary angiogram showed in-stent thrombosis of the initial intervention. Following thrombectomy, balloon angioplasty, and stent, the patient recovered well without additional episodes of hiccups. Although hiccups are not known to present with a predilection for a particular cause of myocardial ischemia, this case may additionally be explained by the sympathomimetic effects of cocaine, which lead to vasoconstriction of coronary arteries. CONCLUSIONS Hiccups associated with cardiac enzyme elevation and EKG ST-segment elevation before and after percutaneous coronary intervention (PCI) maybe a manifestation of acute MI with or without stent. The fact that this patient was a cocaine user may have contributed to the unique presentation.
[Mh] Termos MeSH primário: Trombose Coronária/complicações
Soluço/etiologia
Infarto do Miocárdio com Supradesnível do Segmento ST/etiologia
Stents/efeitos adversos
[Mh] Termos MeSH secundário: Transtornos Relacionados ao Uso de Cocaína/complicações
Trombose Coronária/diagnóstico
Trombose Coronária/etiologia
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:28975284
[Au] Autor:Haymond S; Nagpal G; Heiman H
[Ad] Endereço:Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
[Ti] Título:Urine Drug Screens to Monitor Opioid Use for Managing Chronic Pain.
[So] Source:JAMA;318(11):1061-1062, 2017 Sep 19.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Analgésicos Opioides/uso terapêutico
Transtornos Relacionados ao Uso de Cocaína/diagnóstico
Cocaína/urina
Hidrocodona/uso terapêutico
Dor Lombar/tratamento farmacológico
Detecção do Abuso de Substâncias
[Mh] Termos MeSH secundário: Dor Crônica/tratamento farmacológico
Monitoramento de Medicamentos
Feminino
Seres Humanos
Hidrocodona/urina
Imunoensaio
Meia-Idade
Transtornos Relacionados ao Uso de Opioides/diagnóstico
Sensibilidade e Especificidade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid); 6YKS4Y3WQ7 (Hydrocodone); I5Y540LHVR (Cocaine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.10593


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[PMID]:28838510
[Au] Autor:Poon SS; Nawaytou O; Hing A; Field M
[Ad] Endereço:Thoracic Aneurysm Services, Department of Cardiac Surgery, Liverpool Heart and Chest Hospital, Liverpool, United Kingdom. Electronic address: sspoon@doctors.net.uk.
[Ti] Título:Giant Aortic Thrombus in the Ascending Aorta and Perforation of Bowel Associated With Cocaine Use.
[So] Source:Ann Thorac Surg;104(3):e219-e220, 2017 Sep.
[Is] ISSN:1552-6259
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A floating giant aortic thrombus is a rare finding in the absence of any coagulation disorder. Patients usually remain asymptomatic until the development of embolic complications. Our report highlights cocaine abuse as a potential cause of aortic thrombus and bowel perforation. Clinicians should have a high index of suspicion when treating patients with a history of illicit cocaine use with signs and symptoms of arterial ischemia. The risks of cardiovascular and abdominal complications related to cocaine use should not be underestimated. Prompt diagnosis is required to circumvent potentially life-threatening complications.
[Mh] Termos MeSH primário: Doenças da Aorta/etiologia
Transtornos Relacionados ao Uso de Cocaína/complicações
Perfuração Intestinal/etiologia
Doenças do Jejuno/etiologia
Trombose/etiologia
[Mh] Termos MeSH secundário: Adulto
Doenças da Aorta/diagnóstico
Doenças da Aorta/cirurgia
Seres Humanos
Perfuração Intestinal/diagnóstico
Perfuração Intestinal/cirurgia
Doenças do Jejuno/diagnóstico
Doenças do Jejuno/cirurgia
Masculino
Trombose/diagnóstico
Trombose/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE


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[PMID]:28751460
[Au] Autor:Warlow SM; Robinson MJF; Berridge KC
[Ad] Endereço:Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109, and smwarlow@umich.edu.
[Ti] Título:Optogenetic Central Amygdala Stimulation Intensifies and Narrows Motivation for Cocaine.
[So] Source:J Neurosci;37(35):8330-8348, 2017 Aug 30.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Addiction is often characterized by intense motivation for a drug, which may be narrowly focused at the expense of other rewards. Here, we examined the role of amygdala-related circuitry in the amplification and narrowing of motivation focus for intravenous cocaine. We paired optogenetic channelrhodopsin (ChR2) stimulation in either central nucleus of amygdala (CeA) or basolateral amygdala (BLA) of female rats with one particular nose-poke porthole option for earning cocaine infusions (0.3 mg/kg, i.v.). A second alternative porthole earned identical cocaine but without ChR2 stimulation. Consequently, CeA rats quickly came to pursue their CeA ChR2-paired cocaine option intensely and exclusively, elevating cocaine intake while ignoring their alternative cocaine alone option. By comparison, BLA ChR2 pairing failed to enhance cocaine motivation. CeA rats also emitted consummatory bites toward their laser-paired porthole, suggesting that higher incentive salience made that cue more attractive. A separate progressive ratio test of incentive motivation confirmed that CeA ChR2 amplified rats' motivation, raising their breakpoint effort price for cocaine by 10-fold. However, CeA ChR2 laser on its own lacked any reinforcement value: laser by itself was never self-stimulated, not even by the same rats in which it amplified motivation for cocaine. Conversely, CeA inhibition by muscimol/baclofen microinjections prevented acquisition of cocaine self-administration and laser preference, whereas CeA inhibition by optogenetic halorhodopsin suppressed cocaine intake, indicating that CeA circuitry is needed for ordinary cocaine motivation. We conclude that CeA ChR2 excitation paired with a cocaine option specifically focuses and amplifies motivation to produce intense pursuit and consumption focused on that single target. In addiction, intense incentive motivation often becomes narrowly focused on a particular drug of abuse. Here we show that pairing central nucleus of amygdala (CeA) optogenetic stimulation with one option for earning intravenous cocaine makes that option almost the exclusive focus of intense pursuit and consumption. CeA stimulation also elevated the effort cost rats were willing to pay for cocaine and made associated cues become intensely attractive. However, we also show that CeA laser had no reinforcing properties at all when given alone for the same rats. Therefore, CeA laser pairing makes its associated cocaine option and cues become powerfully attractive in a nearly addictive fashion.
[Mh] Termos MeSH primário: Comportamento Aditivo/fisiopatologia
Transtornos Relacionados ao Uso de Cocaína/fisiopatologia
Estimulação Elétrica
Motivação
Optogenética/métodos
Recompensa
[Mh] Termos MeSH secundário: Tonsila do Cerebelo
Animais
Feminino
Ratos
Ratos Sprague-Dawley
Reforço (Psicologia)
Autoadministração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170729
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.3141-16.2017


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Texto completo SciELO Brasil
[PMID]:28724038
[Au] Autor:Antonio N; Diehl A; Niel M; Pillon S; Ratto L; Pinheiro MC; Silveira D; Otani TZ; Otani V; Cordeiro Q; Ushida R
[Ad] Endereço:Center for Integrated Mental Health (CAISM), Faculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP), São Paulo, SP, Brazil.
[Ti] Título:Sexual addiction in drug addicts: The impact of drug of choice and poly-addiction.
[So] Source:Rev Assoc Med Bras (1992);63(5):414-421, 2017 May.
[Is] ISSN:1806-9282
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Objective:: To compare the risk of comorbid sexual addiction in a sample of individuals with a diagnosis of substance dependence, stratifying the sample by drug of choice as well as by mono versus polysubstance addiction. Method:: All data were collected at Santa Casa de São Paulo, Brazil. The study sample comprised all alcohol or drug dependents admitted to the Addiction Treatment Unit between November 2013 and August 2014. A generalized linear model with a binomial distribution was performed to compare the odds of having a Sexual Addiction Screening Test (SAST) score greater than 6 points in the subgroups analyzed. Results:: A total of 133 participants were included in our analysis, all reporting cocaine/crack and/or alcohol as drug of choice. Polysubstance addicts had a significant higher risk of a positive screening for sexual addiction compared to monosubstance addicts, age-sex adjusted odds ratios of sexual addiction being respectively 2.72 (95CI 1.1-6.71) and 0.37 (95CI 0.15-0.91). The odds of a SAST score greater than 6 was not statistically different between the cocaine/crack and alcohol groups, respectively 0.38 (95CI 0.14-1.02) and 2.67 (95CI 0.98-7.25). We found a significant relation between stronger drug addiction and greater levels of sexual addiction in the cocaine/crack group (p=0.0012), but not in the alcohol group. Conclusion:: Our study reinforces the importance of assessing sexual behavior of drug addicts in clinical practice, especially considering users of multiple substances or with severe dependence.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Álcool/complicações
Comportamento Aditivo/induzido quimicamente
Transtornos Relacionados ao Uso de Cocaína/complicações
Medição de Risco/métodos
Comportamento Sexual/efeitos dos fármacos
Disfunções Sexuais Psicogênicas/induzido quimicamente
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Transtornos Relacionados ao Uso de Álcool/psicologia
Comportamento Aditivo/psicologia
Brasil
Transtornos Relacionados ao Uso de Cocaína/psicologia
Cocaína Crack/efeitos adversos
Usuários de Drogas/psicologia
Feminino
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Escalas de Graduação Psiquiátrica
Fatores de Risco
Índice de Gravidade de Doença
Fatores Sexuais
Comportamento Sexual/psicologia
Fatores Socioeconômicos
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Crack Cocaine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE



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