Base de dados : MEDLINE
Pesquisa : C25.775.467 [Categoria DeCS]
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[PMID]:28759776
[Au] Autor:Ventura F; Barranco R; Landolfa MC; Gallo M; Castiglione AG; Orcioni GF; De Stefano F
[Ad] Endereço:Department of Legal and Forensic Medicine, University of Genova, Via De Toni 12, 16132, Genova, Italy. Electronic address: francesco.ventura@unige.it.
[Ti] Título:Fatal poisoning by butane sniffing: A forensic analysis and immunohistochemical detection of myocardial hypoxic damage.
[So] Source:J Forensic Leg Med;51:57-62, 2017 Oct.
[Is] ISSN:1878-7487
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although less widespread than twenty years ago, inhalant abuse remains an on-going problem, whose incidence among U.S. teenagers and young adults ranges from 10 to 15%. Death due to the inhalation of vapor from halogenated hydrocarbons is a well-known phenomenon, yet few cases of fatal butane-gas poisoning have been described. Many cases of volatile substance abuse in prison populations have been reported: drug-addicted inmates often resort to this alternative practice when unable to get their habitual drugs of abuse. A similar pattern occurs especially among adolescents. The study herein described was conducted including all cases of fatal acute intoxication of butane gas examined from 2007 to 2015 at the Institute of Legal Medicine and Forensic Sciences of the University of Genoa. In the absence of overt and specific macroscopic and histological findings indicating cause and pathological mechanism of death, we aimed to assess whether recent cardiac lesions were detectable by way of immunohistochemical (IHC) analysis. Specifically, fibronectin and troponin C expression in myocardial tissues were investigated in deaths from acute butane-gas poisoning so as to better define the underlying pathological mechanisms. IHC findings were indicative of hypoxic cardiac damage. In all cases, positivity to fibronectin and mildly to moderately reduced troponin C expression in cardiac muscle cells were immunohistochemically ascertained.
[Mh] Termos MeSH primário: Butanos/envenenamento
Hipóxia/patologia
Abuso de Inalantes
Miocárdio/patologia
[Mh] Termos MeSH secundário: Adulto
Fibronectinas/metabolismo
Seres Humanos
Hipóxia/induzido quimicamente
Imuno-Histoquímica
Pulmão/patologia
Masculino
Miocárdio/metabolismo
Troponina C/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butanes); 0 (Fibronectins); 0 (Troponin C)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE


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[PMID]:28263233
[Au] Autor:Joshi K; Barletta M; Wurpel J
[Ad] Endereço:From the St. John's University, Queens, NY.
[Ti] Título:Cardiotoxic (Arrhythmogenic) Effects of 1,1-Difluoroethane Due to Electrolyte Imbalance and Cardiomyocyte Damage.
[So] Source:Am J Forensic Med Pathol;38(2):115-125, 2017 Jun.
[Is] ISSN:1533-404X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Inhalant abuse is the intentional inhalation of chemical vapors to attain euphoric effects. Many common household products are abused by inhalation and one is 1,1-difluoroethane (DFE), which is a halogenated hydrocarbon used in refrigeration, dust-off spray, and airbrush painting. Although many human DFE abuse cases have been studied, the etiology and mechanism of sudden death is still unknown. In this study, an animal model was used to simulate the human conditions of DFE inhalation abuse that results in sudden death.Current research targets mechanistic studies involving electrolyte changes and cardiomyocyte damage after DFE administration in vivo. To investigate these changes, Sprague Dawley rats (N = 6) were exposed to 30 seconds of 20 L/min of DFE in multiple doses. Isoflurane acted as a control. Two additional groups, epinephrine and epinephrine + DFE, were included to simulate the clinical condition of DFE abuse. Plasma sodium, potassium, calcium, and magnesium levels were measured, followed by lactate dehydrogenase, creatine kinase, and cardiac troponin I levels. In addition, oxidative stress markers were also evaluated in all animal groups. Electrolyte levels showed a significant rise in plasma potassium and magnesium levels for the treated groups. In addition, lactate dehydrogenase, creatine kinase, and cardiac troponin I levels in DFE and epinephrine + DFE administered rats were significantly elevated as compared with control. Some oxidative stress makers were also elevated significantly in treatment groups. Furthermore, histopathological analysis showed hyperemia/congestion in treated rats.These results support cardiotoxic effects indicating that DFE results in fatal arrhythmias, and the study can be important during clinical cases involving inhalant abuse.
[Mh] Termos MeSH primário: Hidrocarbonetos Fluorados/toxicidade
Miócitos Cardíacos/efeitos dos fármacos
Solventes/toxicidade
Desequilíbrio Hidroeletrolítico/induzido quimicamente
[Mh] Termos MeSH secundário: Trifosfato de Adenosina/sangue
Animais
Arritmias Cardíacas/induzido quimicamente
Creatina Quinase/sangue
Eletrocardiografia
Epinefrina/sangue
Abuso de Inalantes
Miocárdio/patologia
Miócitos Cardíacos/patologia
Ratos Sprague-Dawley
Troponina I/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrocarbons, Fluorinated); 0 (Solvents); 0 (Troponin I); 0B1U8K2ME0 (1,1-difluoroethane); 8L70Q75FXE (Adenosine Triphosphate); EC 2.7.3.2 (Creatine Kinase); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.1097/PAF.0000000000000262


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[PMID]:27694447
[Au] Autor:Jayanth SH; Hugar BS; Praveen S; Girish Chandra YP
[Ad] Endereço:Department of Forensic Medicine, M.S. Ramaiah Medical College, Bangalore, India.
[Ti] Título:Glue sniffing.
[So] Source:Med Leg J;85(1):38-42, 2017 Mar.
[Is] ISSN:2042-1834
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Inhalant abuse refers to the inhalation of volatile substances for their euphoric effects. Glues and adhesives have been abused inhalants for decades and so the term "glue sniffing" attached to the habit. These days many substances used are not adhesives and the most accurate title of "solvent abuse" has been given to this widespread and dangerous habit. The various methods of inhalational abuse include huffing, bagging, dusting, glading, and sniffing. We report one such case of a 22-year-old male who was found in an unresponsive state at his residence with a plastic cover around his head and empty tubes of "Fevibond" glue beside him. He died on the way to hospital. At autopsy, conjunctival and visceral congestion were found with pulmonary edema and petechiae over visceral pericardium. The viscera were analyzed, and the presence of toluene in his liver and blood was reported.
[Mh] Termos MeSH primário: Abuso de Inalantes/complicações
Abuso de Inalantes/patologia
[Mh] Termos MeSH secundário: Medicina Legal/métodos
Seres Humanos
Masculino
Transtornos Relacionados ao Uso de Substâncias/complicações
Transtornos Relacionados ao Uso de Substâncias/patologia
Tolueno/efeitos adversos
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
3FPU23BG52 (Toluene)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE
[do] DOI:10.1177/0025817216671106


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[PMID]:27338970
[Au] Autor:Storck M; Black L; Liddell M
[Ad] Endereço:Department of Child Psychiatry, Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA 98105, USA. Electronic address: storck@uw.edu.
[Ti] Título:Inhalant Abuse and Dextromethorphan.
[So] Source:Child Adolesc Psychiatr Clin N Am;25(3):497-508, 2016 Jul.
[Is] ISSN:1558-0490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Inhalant abuse is the intentional inhalation of a volatile substance for the purpose of achieving an altered mental state. As an important, yet underrecognized form of substance abuse, inhalant abuse crosses all demographic, ethnic, and socioeconomic boundaries, causing significant morbidity and mortality in school-aged and older children. This review presents current perspectives on epidemiology, detection, and clinical challenges of inhalant abuse and offers advice regarding the medical and mental health providers' roles in the prevention and management of this substance abuse problem. Also discussed is the misuse of a specific "over-the-counter" dissociative, dextromethorphan.
[Mh] Termos MeSH primário: Antitussígenos/efeitos adversos
Antitussígenos/envenenamento
Dextrometorfano/envenenamento
Abuso de Inalantes/epidemiologia
Transtornos Relacionados ao Uso de Substâncias/diagnóstico
Transtornos Relacionados ao Uso de Substâncias/prevenção & controle
[Mh] Termos MeSH secundário: Seres Humanos
Abuso de Inalantes/prevenção & controle
Transtornos Relacionados ao Uso de Substâncias/mortalidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antitussive Agents); 7355X3ROTS (Dextromethorphan)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170328
[Lr] Data última revisão:
170328
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160625
[St] Status:MEDLINE


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[PMID]:27303242
[Au] Autor:Dinsfriend W; Rao K; Matulevicius S
[Ti] Título:Inhalant-Abuse Myocarditis Diagnosed by Cardiac Magnetic Resonance.
[So] Source:Tex Heart Inst J;43(3):246-8, 2016 Jun.
[Is] ISSN:1526-6702
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Multiple reports of toxic myocarditis from inhalant abuse have been reported. We now report the case of a 23-year-old man found to have toxic myocarditis from inhalation of a hydrocarbon. The diagnosis was made by means of cardiac magnetic resonance imaging with delayed enhancement. The use of cardiac magnetic resonance to diagnose myocarditis has become increasingly common in clinical medicine, although there is not a universally accepted criterion for diagnosis. We appear to be the first to document a case of toxic myocarditis diagnosed by cardiac magnetic resonance. In patients with a history of drug abuse who present with clinical findings that suggest myocarditis or pericarditis, cardiac magnetic resonance can be considered to support the diagnosis.
[Mh] Termos MeSH primário: Hidrocarbonetos/envenenamento
Abuso de Inalantes/complicações
Imagem Cinética por Ressonância Magnética/métodos
Miocardite/induzido quimicamente
Miocárdio/patologia
[Mh] Termos MeSH secundário: Administração por Inalação
Diagnóstico Diferencial
Seres Humanos
Hidrocarbonetos/administração & dosagem
Masculino
Miocardite/diagnóstico
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrocarbons)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160616
[St] Status:MEDLINE
[do] DOI:10.14503/THIJ-14-4919


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[PMID]:26969766
[Au] Autor:Bouchatta O; Ouhaz Z; Ba-Mhamed S; Kerekes N; Bennis M
[Ad] Endereço:Lab of Pharmacology, Neurobiology and Behavior (URAC-37), Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech, Morocco.
[Ti] Título:Acute and chronic glue sniffing effects and consequences of withdrawal on aggressive behavior.
[So] Source:Life Sci;152:14-20, 2016 May 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Drug abuse act on brain mechanisms that cause a high-risk individual to engage in aggressive and violent behavior. While a drug-violence relationship exists, the nature of this relationship is often complex, with intoxication, neurotoxic, and withdrawal effects often being confused and/or confounded. Glue sniffing is often a springboard to the abuse of more addictive drugs. Despite its high prevalence and serious consequences, we know relatively little about the aggressive behavioral effects of volatile inhalants abuse, especially glue. The aim of the present study was to investigate the link between the duration of glue exposure, a common substance abuse problem in Morocco, and the level of aggressive behavior during withdrawal. For this we used the isolation-induced aggression model "residents" in three groups of mice. The first group served as control resident animals (n=10, without exposure); the second group as experimental resident mice (n=10) tested before and after acute (first day) and chronic exposure to the glue, and at 1 and 2weeks of withdrawal; and the third group of 10 intruder animals. The results showed that the number of attacks decreased (halved) and the latency of the first attack increased (doubled) following acute glue sniffing. However, the effects of chronic exposure and of 1week of withdrawal led to an increase in the intensity of agonistic encounters. After 2weeks of withdrawal, the intensity of aggressive behavior decreased again. These results indicated that chronic glue exposure and the first week of withdrawal are associated with increased aggression in mice.
[Mh] Termos MeSH primário: Agressão/psicologia
Abuso de Inalantes/psicologia
Síndrome de Abstinência a Substâncias/psicologia
[Mh] Termos MeSH secundário: Doença Aguda
Adesivos/química
Comportamento Agonístico/efeitos dos fármacos
Animais
Comportamento Animal/efeitos dos fármacos
Doença Crônica
Masculino
Camundongos
Camundongos Endogâmicos C57BL
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adhesives)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170207
[Lr] Data última revisão:
170207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160313
[St] Status:MEDLINE


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[PMID]:26962974
[Au] Autor:Swaim RC
[Ad] Endereço:Colorado State University.
[Ti] Título:Moderating effects of perceived social benefits on inhalant initiation among American Indian and White youth.
[So] Source:Psychol Addict Behav;30(3):398-405, 2016 05.
[Is] ISSN:1939-1501
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study examined whether perceived social benefits moderated the relationship between social influence variables (school attachment, peer inhalant use, perceived family caring, and parental monitoring) and stage of inhalant initiation (Study 1) and lifetime inhalant use (Study 2). Participants were 7th to 12th grade students attending schools on or near American Indian reservations, with comparisons made between American Indian and White students. A total of 3,498 American Indian and 1,596 White students were surveyed. Differences in mean levels of social influence variables were found across ethnicity and stage of inhalant initiation and lifetime inhalant use. Structural equation models were evaluated to examine variable relationships for the 2 studies. For Study 1, social influence variables did not clearly differentiate early versus later inhalant initiators, and perceived social benefits failed to serve as a moderator. More differences were observed between users and nonusers across measures of social influence (Study 2). Perceived social benefits generally did not moderate the relationships, with 2 exceptions. Low perceived social benefits provided greater protection against the influence of peers on lifetime inhalant use among White students, whereas high perceived social benefits increased risk of peer influence among American Indian students. (PsycINFO Database Record
[Mh] Termos MeSH primário: Comportamento do Adolescente/etnologia
Grupo com Ancestrais do Continente Europeu/etnologia
Índios Norte-Americanos/etnologia
Abuso de Inalantes/etnologia
Infuência dos Pares
Percepção Social
[Mh] Termos MeSH secundário: Adolescente
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170227
[Lr] Data última revisão:
170227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160311
[St] Status:MEDLINE
[do] DOI:10.1037/adb0000168


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[PMID]:26846567
[Au] Autor:Halliburton AE; Bray BC
[Ad] Endereço:a Psychology, Virginia Tech , Blacksburg , Virginia , USA.
[Ti] Título:Long-Term Prevalence and Demographic Trends in U.S. Adolescent Inhalant Use: Implications for Clinicians and Prevention Scientists.
[So] Source:Subst Use Misuse;51(3):343-56, 2016.
[Is] ISSN:1532-2491
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Inhalant use by adolescents is cause for concern due to the early age of inhalant use initiation and the many short- and long-term health consequences that can occur concurrently with and subsequent to use. However, inhalant use research has been limited relative to the literature available on other drug use. OBJECTIVES: The present research examined long-term trends in inhalant use prevalence, demographic risk factors of inhalant use, and median grade level of first use. METHODS: Monitoring the Future data from 1991 to 2011, which includes information drawn from United States eighth, tenth, and twelfth graders, were examined. The total sample comprised more than one million participants. Results were examined descriptively with figures and quantitatively with mixed-effects regression models of the effect of time on use rates. RESULTS: Inhalant use prevalence rates generally declined over the selected period. Though rates of use by males and females decreased significantly, the proportion of females among lifetime users increased significantly. Whites, Hispanics, and members of uncategorized "other" ethnicities showed the highest prevalence rates. Although the proportion of Whites among lifetime users decreased significantly, the proportion of Hispanics and "other" ethnicities increased significantly. The median first use was between sixth and ninth grade. CONCLUSIONS/IMPORTANCE: Results suggest a need to tailor inhalant use treatment and prevention programs to the needs of specific demographic groups and to target interventions early to prevent youth inhalant use. Strengths, limitations, and directions for future research are discussed.
[Mh] Termos MeSH primário: Comportamento do Adolescente
Demografia/tendências
Abuso de Inalantes/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Comportamento do Adolescente/psicologia
Fatores Etários
Grupos Étnicos/estatística & dados numéricos
Feminino
Seres Humanos
Masculino
Prevalência
Fatores de Risco
Fatores Sexuais
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160206
[St] Status:MEDLINE
[do] DOI:10.3109/10826084.2015.1110169


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[PMID]:26772803
[Au] Autor:McIlroy G; Ford L; Khan JM
[Ad] Endereço:Department of Cardiology, Sandwell and West Birmingham Hospitals NHS Trust, Dudley Road, Birmingham, B18 7QH, UK. graham.mcilroy@doctors.org.uk.
[Ti] Título:Acute myocardial infarction, associated with the use of a synthetic adamantyl-cannabinoid: a case report.
[So] Source:BMC Pharmacol Toxicol;17:2, 2016 Jan 16.
[Is] ISSN:2050-6511
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: "Legal highs" are novel psychoactive substances that have evaded statutory control. Synthetic cannabinoid compounds with adamantane moieties have recently been identified, which have high potency at target receptors and are undetectable on conventional toxicology testing. However, little is known about any harmful effects, and their potential to cause serious ill health. We describe a case of myocardial infarction following the use of this class of drug. CASE PRESENTATION: We report the case of a 39-year-old man admitted after an out-of-hospital cardiac arrest, in whom ECG and elevated cardiac enzymes confirmed ST-elevation myocardial infarction. Normal coronary perfusion was restored after thrombectomy and coronary artery stenting. In the hours preceding his admission, the patient is known to have consumed the legal high product "Black Mamba". Subsequent urine testing confirmed the presence of an adamantyl-group synthetic cannabinoid, whilst cannabis, cocaine, amphetamines and other drugs of abuse were not detected. CONCLUSION: The use of legal highs is being increasingly recognised, but the chemical compositions and physiological effects of these drugs are poorly characterised and are continually changing. Synthetic cannabinoids, rarely identified on toxicological testing, can be linked to serious adverse cardiovascular events. This case highlights the importance of testing for novel psychoactive compounds, and recognising their potential to cause life-threatening conditions.
[Mh] Termos MeSH primário: Adamantano/toxicidade
Canabinoides/toxicidade
Drogas Desenhadas/toxicidade
Abuso de Inalantes/fisiopatologia
Infarto do Miocárdio/etiologia
Psicotrópicos/toxicidade
[Mh] Termos MeSH secundário: Adamantano/administração & dosagem
Adamantano/urina
Administração por Inalação
Adulto
Canabinoides/administração & dosagem
Canabinoides/urina
Drogas Desenhadas/administração & dosagem
Drogas Desenhadas/análise
Diagnóstico Diferencial
Serviços Médicos de Emergência
Inglaterra
Seres Humanos
Abuso de Inalantes/diagnóstico
Abuso de Inalantes/urina
Masculino
Infarto do Miocárdio/terapia
Psicotrópicos/administração & dosagem
Psicotrópicos/urina
Toxicocinética
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cannabinoids); 0 (Designer Drugs); 0 (Psychotropic Drugs); PJY633525U (Adamantane)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160117
[St] Status:MEDLINE
[do] DOI:10.1186/s40360-016-0045-1


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[PMID]:26580136
[Au] Autor:Grant BF; Saha TD; Ruan WJ; Goldstein RB; Chou SP; Jung J; Zhang H; Smith SM; Pickering RP; Huang B; Hasin DS
[Ad] Endereço:Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland.
[Ti] Título:Epidemiology of DSM-5 Drug Use Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions-III.
[So] Source:JAMA Psychiatry;73(1):39-47, 2016 Jan.
[Is] ISSN:2168-6238
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:IMPORTANCE: Current information on the prevalence and sociodemographic and clinical profiles of individuals in the general population with DSM-5 drug use disorder (DUD) is limited. Given the present societal and economic context in the United States and the new diagnostic system, up-to-date national information is needed from a single uniform data source. OBJECTIVE: To present nationally representative findings on the prevalence, correlates, psychiatric comorbidity, disability, and treatment of DSM-5 DUD diagnoses overall and by severity level. DESIGN, SETTING, AND PARTICIPANTS: In-person interviews were conducted with 36,309 adults in the 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions-III, a cross-sectional representative survey of the United States. The household response rate was 72%; person-level response rate, 84%; and overall response rate, 60.1%. Data were collected April 2012 through June 2013 and analyzed from February through March 2015. MAIN OUTCOMES AND MEASURES: Twelve-month and lifetime DUD, based on amphetamine, cannabis, club drug, cocaine, hallucinogen, heroin, nonheroin opioid, sedative/tranquilizer, and/or solvent/inhalant use disorders. RESULTS: Prevalences of 12-month and lifetime DUD were 3.9% and 9.9%, respectively. Drug use disorder was generally greater among men, white and Native American individuals, younger and previously or never married adults, those with lower education and income, and those residing in the West. Significant associations were found between 12-month and lifetime DUD and other substance use disorders. Significant associations were also found between any 12-month DUD and major depressive disorder (odds ratio [OR], 1.3; 95% CI, 1.09-1.64), dysthymia (OR, 1.5; 95% CI, 1.09-2.02), bipolar I (OR, 1.5; 95% CI, 1.06-2.05), posttraumatic stress disorder (OR, 1.6; 95% CI, 1.27-2.10), and antisocial (OR, 1.4; 95% CI, 1.11-1.75), borderline (OR, 1.8; 95% CI, 1.41-2.24), and schizotypal (OR, 1.5; 95% CI, 1.18-1.87) personality disorders. Similar associations were found for any lifetime DUD with the exception that lifetime DUD was also associated with generalized anxiety disorder (OR, 1.3; 95% CI, 1.06-1.49), panic disorder (OR, 1.3; 95% CI, 1.06-1.59), and social phobia (OR, 1.3; 95% CI, 1.09-1.64). Twelve-month DUD was associated with significant disability, increasing with DUD severity. Among respondents with 12-month and lifetime DUD, only 13.5% and 24.6% received treatment, respectively. CONCLUSIONS AND RELEVANCE: DSM-5 DUD is a common, highly comorbid, and disabling disorder that largely goes untreated in the United States. These findings indicate the need for additional studies to understand the broad relationships in more detail; estimate present-day economic costs of DUDs; investigate hypotheses regarding etiology, chronicity, and treatment use; and provide information to policy makers about allocation of resources for service delivery and research. Findings also indicate an urgent need to destigmatize DUD and educate the public, clinicians, and policy makers about its treatment to encourage affected individuals to obtain help.
[Mh] Termos MeSH primário: Transtorno Bipolar/epidemiologia
Transtorno Depressivo Maior/epidemiologia
Transtorno Distímico/epidemiologia
Transtornos da Personalidade/epidemiologia
Transtornos de Estresse Pós-Traumáticos/epidemiologia
Transtornos Relacionados ao Uso de Substâncias/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Transtornos Relacionados ao Uso de Anfetaminas/epidemiologia
Transtorno da Personalidade Antissocial/epidemiologia
Transtorno da Personalidade Borderline/epidemiologia
Transtornos Relacionados ao Uso de Cocaína/epidemiologia
Comorbidade
Manual Diagnóstico e Estatístico de Transtornos Mentais
Feminino
Dependência de Heroína/epidemiologia
Seres Humanos
Abuso de Inalantes/epidemiologia
Masculino
Abuso de Maconha/epidemiologia
Meia-Idade
Transtornos Relacionados ao Uso de Opioides/epidemiologia
Prevalência
Transtorno da Personalidade Esquizotípica/epidemiologia
Índice de Gravidade de Doença
Estados Unidos/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, N.I.H., INTRAMURAL
[Em] Mês de entrada:1605
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:151119
[St] Status:MEDLINE
[do] DOI:10.1001/jamapsychiatry.2015.2132



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