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[PMID]:28651404
[Au] Autor:Yao T; Feng D; Pan MH; Cheng YP; Li CX; Wang J; Feng YL; Shi J; Su T; Chen Q; Shi S; Wang SP
[Ad] Endereço:Department of Epidemiology, Shanxi Medical University, Taiyuan 030001, China.
[Ti] Título:[Correlation between insufficient methadone dosage and morphine positive urine on drop out of treatment in patients with access to methadone maintenance treatment].
[So] Source:Zhonghua Liu Xing Bing Xue Za Zhi;38(5):646-650, 2017 May 10.
[Is] ISSN:0254-6450
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To estimate the incidence of drop out of treatment in patients with access to methadone maintenance treatment and explore the correlation and interaction between insufficient methadone dosage and morphine positive urine on the drop out in Guangxi Zhuang Autonomous Region. Face to face interview was conducted in 1 031 patients at 3 methadone maintenance treatment clinics in Guangxi. The study included 1 031 participants, 40.6 of them (419/1 031) had stopped treatment. The drop out rates in urine morphine positive group and methadone dosage<100 mg/d group were 57.6 (99/172) and 37.4 (347/929) respectively, higher than those in urine morphine negative group and methadone dosage ≥100 mg/d group (42.3 , 363/859, and 26.5 , 27/102). Orderly logistic regression analysis results showed that after adjusted factors, such as gender, age, marital status, ethnic group, patients who received a dosage less than 100 mg/day ( =3.05, 95 : 1.84-5.06) and had morphine positive urine ( =2.25, 95 : 1.59-3.19) were more likely to drop out of the treatment. Interaction analysis showed that dosage less than 100 mg/d and morphine positive urine during treatment had additive interaction ( =256.46, =0.87, = 8.05) and multiplication interaction ( =2.45, 95 : 1.71-3.49). Insufficient dosage and morphine positive urine were significantly correlated with drop out of treatment in patients with access to methadone maintenance treatment.
[Mh] Termos MeSH primário: Metadona/uso terapêutico
Dependência de Morfina/reabilitação
Morfina/urina
Entorpecentes/uso terapêutico
Tratamento de Substituição de Opiáceos
Pacientes Desistentes do Tratamento/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
China/epidemiologia
Relação Dose-Resposta a Droga
Feminino
Acesso aos Serviços de Saúde
Seres Humanos
Incidência
Entrevistas como Assunto
Masculino
Metadona/administração & dosagem
Metadona/provisão & distribuição
Dependência de Morfina/epidemiologia
Dependência de Morfina/urina
Detecção do Abuso de Substâncias
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Narcotics); 76I7G6D29C (Morphine); UC6VBE7V1Z (Methadone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0254-6450.2017.05.018


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[PMID]:28319053
[Au] Autor:Xu J; Lu Z; Narayan A; Le Rouzic VP; Xu M; Hunkele A; Brown TG; Hoefer WF; Rossi GC; Rice RC; Martínez-Rivera A; Rajadhyaksha AM; Cartegni L; Bassoni DL; Pasternak GW; Pan YX
[Ti] Título:Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine.
[So] Source:J Clin Invest;127(4):1561-1573, 2017 Apr 03.
[Is] ISSN:1558-8238
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Extensive 3' alternative splicing of the mu opioid receptor gene OPRM1 creates multiple C-terminal splice variants. However, their behavioral relevance remains unknown. The present study generated 3 mutant mouse models with truncated C termini in 2 different mouse strains, C57BL/6J (B6) and 129/SvEv (129). One mouse truncated all C termini downstream of Oprm1 exon 3 (mE3M mice), while the other two selectively truncated C-terminal tails encoded by either exon 4 (mE4M mice) or exon 7 (mE7M mice). Studies of these mice revealed divergent roles for the C termini in morphine-induced behaviors, highlighting the importance of C-terminal variants in complex morphine actions. In mE7M-B6 mice, the exon 7-associated truncation diminished morphine tolerance and reward without altering physical dependence, whereas the exon 4-associated truncation in mE4M-B6 mice facilitated morphine tolerance and reduced morphine dependence without affecting morphine reward. mE7M-B6 mutant mice lost morphine-induced receptor desensitization in the brain stem and hypothalamus, consistent with exon 7 involvement in morphine tolerance. In cell-based studies, exon 7-associated variants shifted the bias of several mu opioids toward ß-arrestin 2 over G protein activation compared with the exon 4-associated variant, suggesting an interaction of exon 7-associated C-terminal tails with ß-arrestin 2 in morphine-induced desensitization and tolerance. Together, the differential effects of C-terminal truncation illustrate the pharmacological importance of OPRM1 3' alternative splicing.
[Mh] Termos MeSH primário: Analgésicos Opioides/farmacologia
Morfina/farmacologia
Receptores Opioides mu/metabolismo
[Mh] Termos MeSH secundário: Processamento Alternativo
Animais
Encéfalo/metabolismo
Códon sem Sentido
Relação Dose-Resposta a Droga
Tolerância a Medicamentos
Éxons
Trânsito Gastrointestinal/efeitos dos fármacos
Guanosina 5'-O-(3-Tiotrifosfato)/metabolismo
Locomoção/efeitos dos fármacos
Masculino
Camundongos da Linhagem 129
Camundongos Endogâmicos C57BL
Dependência de Morfina/genética
Ligação Proteica
Isoformas de Proteínas/genética
Isoformas de Proteínas/metabolismo
Receptores Opioides mu/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Codon, Nonsense); 0 (Oprm protein, mouse); 0 (Protein Isoforms); 0 (Receptors, Opioid, mu); 37589-80-3 (Guanosine 5'-O-(3-Thiotriphosphate)); 76I7G6D29C (Morphine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE


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[PMID]:28130112
[Au] Autor:Rahmati B; Beik A
[Ad] Endereço:Neurophysiology Research Center, Shahed University, 1417953836 Tehran, Iran; Department of Physiology, School of Medicine, Shahed University, 3319118651 Tehran, Iran. Electronic address: batrahmati@yahoo.com.
[Ti] Título:Prevention of morphine dependence and tolerance by Nepeta menthoides was accompanied by attenuation of Nitric oxide overproduction in male mice.
[So] Source:J Ethnopharmacol;199:39-51, 2017 Mar 06.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Repeated administration of morphine for chronic pain leads to dependence and tolerance that limits clinical usage. Nepeta menthoides is commonly known as Iranian Ustukhuddoos and are administered in traditional medicine for gastrodynia, bone pain, blood depurative and restlessness. AIMS OF STUDY: To investigate the effects of Nepeta menthoides on expression and acquisition of morphine dependence and tolerance in mice with regard to oxidative stress. MATERIALS AND METHODS: Morphine dependence in mice was developed by administration of gradually increasing doses of morphine twice daily for 7 consecutive days. In experimental groups, administration of Nepeta menthoides (200 and 400mg/kg), methadone and their combination were performed 60min prior to each morphine injection (for acquisition) or the last injection of morphine on test day (for expression). Morphine tolerance was measured by the tail-immersion test before and after the administration of a single dose of morphine (100mg/kg; i.p.) on the test day (8th day). Morphine dependence was also evaluated by counting the number of jumps after the injection of naloxone (5mg/kg; i.p.). RESULTS: Nepeta menthoides, similar to methadone, significantly prevented the development (but not the expression) of morphine dependence, tolerance, and potentiated morphine antinociception and also reduced (23.23±1.15) Nitric oxide (NO) overproduction (35.23±3.36) (in compared with naloxone group (6.3±0.52)). However, single and repeated application of the extract could not change high single-dose morphine analgesia. CONCLUSION: It appears that Nepeta menthoides and methadone prevented morphine dependence and tolerance, partly through inhibition of the NO overproduction.
[Mh] Termos MeSH primário: Dependência de Morfina/metabolismo
Dependência de Morfina/prevenção & controle
Nepeta
Óxido Nítrico/antagonistas & inibidores
Óxido Nítrico/biossíntese
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Tolerância a Medicamentos/fisiologia
Masculino
Metadona/farmacologia
Metadona/uso terapêutico
Camundongos
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/fisiologia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Distribuição Aleatória
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 31C4KY9ESH (Nitric Oxide); UC6VBE7V1Z (Methadone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170129
[St] Status:MEDLINE


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[PMID]:28081197
[Au] Autor:Mattei V; Martellucci S; Santilli F; Manganelli V; Garofalo T; Candelise N; Caruso A; Sorice M; Scaccianoce S; Misasi R
[Ad] Endereço:Laboratorio di Medicina Sperimentale e Patologia Ambientale, Polo Universitario di Rieti "Sabina Universitas", Rieti, Italia.
[Ti] Título:Morphine Withdrawal Modifies Prion Protein Expression in Rat Hippocampus.
[So] Source:PLoS One;12(1):e0169571, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The hippocampus is a vulnerable brain structure susceptible to damage during aging and chronic stress. Repeated exposure to opioids may alter the brain so that it functions normally when the drugs are present, thus, a prolonged withdrawal might lead to homeostatic changes headed for the restoration of the physiological state. Abuse of morphine may lead to Reacting Oxygen Species-induced neurodegeneration and apoptosis. It has been proposed that during morphine withdrawal, stress responses might be responsible, at least in part, for long-term changes of hippocampal plasticity. Since prion protein is involved in both, Reacting Oxygen Species mediated stress responses and synaptic plasticity, in this work we investigate the effect of opiate withdrawal in rats after morphine treatment. We hypothesize that stressful stimuli induced by opiate withdrawal, and the subsequent long-term homeostatic changes in hippocampal plasticity, might modulate the Prion protein expression. Our results indicate that abstinence from the opiate induced a time-dependent and region-specific modification in Prion protein content, indeed during morphine withdrawal a selective unbalance of hippocampal Prion Protein is observable. Moreover, Prion protein overexpression in hippocampal tissue seems to generate a dimeric structure of Prion protein and α-cleavage at the hydrophobic domain. Stress factors or toxic insults can induce cytosolic dimerization of Prion Protein through the hydrophobic domain, which in turn, it stimulates the α-cleavage and the production of neuroprotective Prion protein fragments. We speculate that this might be the mechanism by which stressful stimuli induced by opiate withdrawal and the subsequent long-term homeostatic changes in hippocampal plasticity, modulate the expression and the dynamics of Prion protein.
[Mh] Termos MeSH primário: Regulação da Expressão Gênica
Hipocampo/metabolismo
Dependência de Morfina/metabolismo
Proteínas Priônicas/biossíntese
Proteólise
Síndrome de Abstinência a Substâncias/metabolismo
[Mh] Termos MeSH secundário: Animais
Hipocampo/patologia
Masculino
Dependência de Morfina/patologia
Domínios Proteicos
Ratos
Ratos Sprague-Dawley
Espécies Reativas de Oxigênio/metabolismo
Síndrome de Abstinência a Substâncias/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Prion Proteins); 0 (Reactive Oxygen Species)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0169571


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[PMID]:28062186
[Au] Autor:Pajohanfar NS; Mohebbi E; Rad A; Pejhan A; Nazemi S; Amin B
[Ad] Endereço:Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran.
[Ti] Título:Protective effects of atorvastatin against morphine-induced tolerance and dependence in mice.
[So] Source:Brain Res;1657:333-339, 2017 Feb 15.
[Is] ISSN:1872-6240
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In this study, we evaluated the effects of atorvastatin, a lipid-lowering medication on morphine-induced tolerance and dependence in mice. METHODS: Tolerance was induced by subcutaneous administration of morphine (20mg/kg) to animals, twice a day for 9days. Atorvastatin was given at the doses of 5, 10 and 20mg/kg, 30min before each morphine administration, once daily for 9days. Hot plate test was employed to assess antinociceptive effect of morphine on days 1, 3, 5, 7 and 9. Dependence was evaluated by naloxone-precipitated withdrawal syndrome. We attempted to verify withdrawal regulation of induced nitric oxide synthase (iNOS), astroglia marker, glial fibrillary acidic protein (GFAP), ionized calcium-binding protein (Iba1), a microglia activation marker, a pro-inflammatory mediator, tumor necrosis alpha (TNF-α) and immune receptor, toll like receptor 4 (TLR-4) genes by real-time polymerase chain reaction (RT-PCR). Lipid peroxidation was estimated by assessing malondialdehyde (MDA) content in the spinal cord of animals. RESULTS: Tolerance to antinociceptive effects of morphine was observed on days 7 and 9. Decrease in morphine-induced antinociception was reversed by concomitant intraperitoneal administration of atorvastatin (10 and 20mg/kg). Atorvastatin (10 and 20mg/kg) mitigated naloxone-induced withdrawal parameters. Brain expression levels of TNF-α, GFAP, Iba1 and iNOS increased in morphine withdrawn animals which were attenuated by nine days treatment with atorvastatin. Increased MDA was also normalized in withdrawn animals received atorvastatin. CONCLUSION: Atorvastatin exhibits meaningful protective effects against both tolerance to antinociceptive effects of morphine and withdrawal-induced behavioral profile. Neuroprotective effects of atorvastatin is further supported via inhibition of glia activity and antioxidant effects.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Atorvastatina Cálcica/farmacologia
Tolerância a Medicamentos
Dependência de Morfina/tratamento farmacológico
Morfina/farmacologia
Entorpecentes/farmacologia
[Mh] Termos MeSH secundário: Animais
Astrócitos/efeitos dos fármacos
Astrócitos/metabolismo
Encéfalo/efeitos dos fármacos
Encéfalo/metabolismo
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Avaliação Pré-Clínica de Medicamentos
Tolerância a Medicamentos/fisiologia
Masculino
Camundongos
Microglia/efeitos dos fármacos
Microglia/metabolismo
Dependência de Morfina/metabolismo
Naloxona/farmacologia
Nociceptividade/efeitos dos fármacos
Nociceptividade/fisiologia
Distribuição Aleatória
Síndrome de Abstinência a Substâncias/tratamento farmacológico
Síndrome de Abstinência a Substâncias/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Narcotics); 36B82AMQ7N (Naloxone); 48A5M73Z4Q (Atorvastatin Calcium); 76I7G6D29C (Morphine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170108
[St] Status:MEDLINE


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[PMID]:28049029
[Au] Autor:Wan L; Bi J; Li J; Zuo Z
[Ad] Endereço:Department of Anesthesiology, University of Virginia, Charlottesville, VA, United States; Department of Anesthesiology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China.
[Ti] Título:Glutamate transporter type 3 participates in maintaining morphine-induced conditioned place preference.
[So] Source:Neuroscience;344:67-73, 2017 Mar 06.
[Is] ISSN:1873-7544
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Glutamate transporters (EAAT) have been implicated in the drug addiction behavior. We determined whether EAAT type 3 (EAAT3) played a role in morphine addiction. Six- to eight-week-old EAAT3 knockout (EAAT3 ) mice and their wild-type littermates received 3 intraperitoneal injections of 10mg/kg morphine, each on an alternative day, to induce conditioned place preference (CPP). Two days after the place preference returned to baseline, mice received 2.5mg/kg morphine to induce reinstatement. Some mice received intraperitoneal injection of 4mg/kg riluzole, an EAAT activator, 30min before morphine or saline injection. Hippocampus, medial prefrontal cortex, nucleus accumbens and ventral tegmental area were harvested for Western analysis 24h after the last dose of morphine was injected. Morphine induced CPP in wild-type and EAAT3 mice. Gender is not a statistically significant factor to influence this behavior. This conditioned behavior extinguished after morphine administration was stopped for 8-9days in wild-type mice, while this extinction occurred 6days after discontinuation of morphine injection in EAAT3 mice. A small dose of morphine similarly reinstated the conditioned behavior in the wild-type and EAAT3 mice. Riluzole abolished morphine-induced CPP during the initial place preference. Morphine increased EAAT3 expression in the plasma membrane of medial prefrontal cortex, nucleus accumbens and ventral tegmental area but did not affect EAAT3 expression in the hippocampus. These results suggest that EAAT3 delays the extinction of morphine-induced CPP. EAAT activation may prevent the formation of morphine-induced CPP.
[Mh] Termos MeSH primário: Encéfalo/efeitos dos fármacos
Transportador 3 de Aminoácido Excitatório/metabolismo
Morfina/farmacologia
Entorpecentes/farmacologia
Comportamento Espacial/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Western Blotting
Encéfalo/metabolismo
Condicionamento (Psicologia)/efeitos dos fármacos
Condicionamento (Psicologia)/fisiologia
Antagonistas de Aminoácidos Excitatórios/farmacologia
Transportador 3 de Aminoácido Excitatório/genética
Extinção Psicológica/efeitos dos fármacos
Extinção Psicológica/fisiologia
Feminino
Masculino
Camundongos Knockout
Dependência de Morfina/metabolismo
Riluzol/farmacologia
Comportamento Espacial/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Excitatory Amino Acid Antagonists); 0 (Excitatory Amino Acid Transporter 3); 0 (Narcotics); 0 (Slc1a1 protein, mouse); 76I7G6D29C (Morphine); 7LJ087RS6F (Riluzole)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170104
[St] Status:MEDLINE


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[PMID]:28038985
[Au] Autor:Zhang L; Cui Y; Wang YC; Yin H; Zheng JM; Huang L; Zhao ZW; Li J
[Ad] Endereço:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, China. Electronic address: zhanglei363@163.com.
[Ti] Título:RETRACTED: Exploring the mechanism by which accumbal deep brain stimulation attenuates morphine-induced reinstatement through manganese-enhanced MRI and pharmacological intervention.
[So] Source:Exp Neurol;290:29-40, 2017 04.
[Is] ISSN:1090-2430
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the authors. The authors have requested to retract this paper as the corresponding author had not sought the prior agreement of his co-authors to submit the paper for publication.
[Mh] Termos MeSH primário: Estimulação Encefálica Profunda/métodos
Dependência de Morfina/diagnóstico por imagem
Dependência de Morfina/terapia
Núcleo Accumbens
[Mh] Termos MeSH secundário: Animais
Condicionamento Operante/efeitos dos fármacos
Meios de Contraste
Antagonistas GABAérgicos/farmacologia
Genes fos/efeitos dos fármacos
Interneurônios/efeitos dos fármacos
Imagem por Ressonância Magnética/métodos
Masculino
Manganês
Dependência de Morfina/psicologia
Neurônios Aferentes/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
Recidiva
Ácido gama-Aminobutírico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (GABA Antagonists); 42Z2K6ZL8P (Manganese); 56-12-2 (gamma-Aminobutyric Acid)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170101
[St] Status:MEDLINE


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[PMID]:27901345
[Au] Autor:Hammami-Abrand Abadi A; Miladi-Gorji H
[Ad] Endereço:a Faculty of Psychology and Educational Sciences, University of Semnan, Semnan, Iran.
[Ti] Título:Effects of environmental enrichment on behavioral and spatial cognitive deficits in morphine-dependent and -withdrawn rats.
[So] Source:Can J Physiol Pharmacol;95(2):163-169, 2017 Feb.
[Is] ISSN:1205-7541
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:This study was designed to examine the effect of environmental enrichment during morphine dependence and withdrawal on morphine-induced behavioral and spatial cognitive disorders in morphine-withdrawn rats. Adult male Wistar rats (190 ± 20 g) were injected with bi-daily doses (10 mg/kg, 12 h intervals) of morphine for 14 days. Rats were reared in SE or EE during the development of dependence on morphine and withdrawal. Then, rats were tested for spatial learning and memory (the water maze), spontaneous withdrawal signs, and grooming behavior. We found that the EE blocked chronic morphine-induced partial impairments of spatial memory retention. Moreover, the EE diminished the occurrence of spontaneous morphine withdrawal signs as mild and the self-grooming behavior. Our findings showed that EE ameliorates chronic morphine-induced partial deficits of spatial cognition, obsessive-like behavior, and the overall severity of the morphine withdrawal. Thus, environmental enrichment may be a potential therapeutic strategy for spatial memory and behavioral deficits in morphine-dependent individuals.
[Mh] Termos MeSH primário: Transtornos Cognitivos/psicologia
Meio Ambiente
Dependência de Morfina/psicologia
Síndrome de Abstinência a Substâncias/psicologia
[Mh] Termos MeSH secundário: Animais
Transtornos Cognitivos/complicações
Asseio Animal
Masculino
Aprendizagem em Labirinto
Rememoração Mental
Dependência de Morfina/complicações
Ratos
Síndrome de Abstinência a Substâncias/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161201
[St] Status:MEDLINE
[do] DOI:10.1139/cjpp-2016-0168


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[PMID]:28306133
[Au] Autor:Liu QF; Li L; Guo YQ; Li X; Mou ZD; Wang X; Du GZ
[Ti] Título:Injection of Toll-like receptor 4 siRNA into the ventrolateral periaqueductal gray attenuates withdrawal syndrome in morphine-dependent rats.
[So] Source:Arch Ital Biol;154(4):133-142, 2016 Dec 01.
[Is] ISSN:0003-9829
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:We assessed the role of the Toll-like receptor 4 (TLR4) gene in the ventrolateral periaqueductal gray (vlPAG) region of morphine-dependent rats on attenuating withdrawal syndrome, and regulating glutamic acid decarboxylase (GAD67), glutamic acid (Glu), and gamma-aminobutyric acid (GABA). After siRNA-mediated downregulation of TLR4, changes were observed in withdrawal behavior and downstream signaling molecules. Rats were injected into the vlPAG with TLR4 siRNA, followed by intraperitoneal injection of morphine for 5 consecutive days, and then naloxone, and the behavioral indices of morphine withdrawal were observed. 'Wet-dog' shakes, teeth chattering, and the total scores of withdrawal reactions were reduced. TLR4 expression and Glu levels were reduced, whereas GAD67 and GABA levels were increased. Overall, these findings indicate that modifying TLR4 gene expression in the vlPAG stimulates expression of the downstream signaling molecule, GAD67, which decreases Glu levels and increases GABA levels. This mechanism may explain the inhibition of withdrawal syndrome in morphine-dependent rats.
[Mh] Termos MeSH primário: Glutamato Descarboxilase/biossíntese
Dependência de Morfina/metabolismo
Substância Cinzenta Periaquedutal/metabolismo
Síndrome de Abstinência a Substâncias/metabolismo
Receptor 4 Toll-Like/metabolismo
Ácido gama-Aminobutírico/biossíntese
[Mh] Termos MeSH secundário: Animais
Western Blotting
Cromatografia Líquida de Alta Pressão
Modelos Animais de Doenças
Ensaio de Imunoadsorção Enzimática
Masculino
RNA Interferente Pequeno
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Small Interfering); 0 (Tlr4 protein, rat); 0 (Toll-Like Receptor 4); 56-12-2 (gamma-Aminobutyric Acid); EC 4.1.1.15 (Glutamate Decarboxylase); EC 4.1.1.15 (glutamate decarboxylase 1)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.12871/00039829201644


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Fotocópia
[PMID]:27882888
[Au] Autor:Bodzon-Kulakowska A; Marszalek-Grabska M; Antolak A; Drabik A; Kotlinska JH; Suder P
[Ad] Endereço:AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biochemistry and Neurobiology, Mickiewicza 30, 30-059 Cracow, Poland. abk@agh.edu.pl.
[Ti] Título:Comparison of two freely available software packages for mass spectrometry imaging data analysis using brains from morphine addicted rats.
[So] Source:Eur J Mass Spectrom (Chichester);22(5):229-233, 2016.
[Is] ISSN:1469-0667
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Data analysis from mass spectrometry imaging (MSI) imaging experiments is a very complex task. Most of the software packages devoted to this purpose are designed by the mass spectrometer manufacturers and, thus, are not freely available. Laboratories developing their own MS-imaging sources usually do not have access to the commercial software, and they must rely on the freely available programs. The most recognized ones are BioMap, developed by Novartis under Interactive Data Language (IDL), and Datacube, developed by the Dutch Foundation for Fundamental Research of Matter (FOM-Amolf). These two systems were used here for the analysis of images received from rat brain tissues subjected to morphine influence and their capabilities were compared in terms of ease of use and the quality of obtained results.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Espectrometria de Massas/métodos
Imagem Molecular/métodos
Dependência de Morfina/metabolismo
Software
Análise Serial de Tecidos/métodos
[Mh] Termos MeSH secundário: Algoritmos
Animais
Proteínas do Tecido Nervoso/metabolismo
Ratos
Ratos Wistar
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Distribuição Tecidual
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Nerve Tissue Proteins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161125
[St] Status:MEDLINE



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