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[PMID]:26632202
[Au] Autor:Huang MC; Chen LY; Chen CK; Lin SK
[Ad] Endereço:Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan; Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan.
[Ti] Título:Potential benefit of lamotrigine in managing ketamine use disorder.
[So] Source:Med Hypotheses;87:97-100, 2016 Feb.
[Is] ISSN:1532-2777
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ketamine is an anesthetic derivative of phencyclidine (PCP; 'Angel dust') with dissociative, analgesic and psychedelic properties. Ketamine has become a popular recreational drug of abuse in many parts of the world in recent years. The preclinical studies demonstrate the reinforcing effects of ketamine and long-term ketamine abuse induces a delayed and persistent upregulation of dopamine system. In humans, there have been concerns about its liability to development of addiction. The dilemma of mental professionals in managing the treatment-seeking ketamine abusers comes from a lack of effective pharmacotherapy. Limiting evidence showed that lamotrigine, which inhibits glutamate release, is effective to reduce cocaine craving. We propose that lamotrigine might be beneficial for managing ketamine use disorder clinically. We also reported one case of ketamine use disorder who experienced a great reduction in craving and ketamine use after taking lamotrigine. Although the mechanisms underlying neuroadaptation and reward related to ketamine are not entirely clear, future clinical trials are needed to advance our understanding of the benefit yielded by lamotrigine to treat ketamine use disorder.
[Mh] Termos MeSH primário: Antagonistas de Aminoácidos Excitatórios/uso terapêutico
Ketamina
Abuso de Fenciclidina/tratamento farmacológico
Triazinas/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Animais
Seres Humanos
Ketamina/administração & dosagem
Ketamina/toxicidade
Masculino
Modelos Biológicos
Abuso de Fenciclidina/fisiopatologia
Abuso de Fenciclidina/psicologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Excitatory Amino Acid Antagonists); 0 (Triazines); 690G0D6V8H (Ketamine); U3H27498KS (lamotrigine)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151204
[St] Status:MEDLINE


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[PMID]:27282013
[Au] Autor:Eggleston W; Stork C
[Ti] Título:Generation Z: Adolescent Xenobiotic Abuse in the 21st Century.
[So] Source:Adolesc Med State Art Rev;26(3):570-88, 2015 Dec.
[Is] ISSN:1934-4287
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:NMDA receptor antagonists include the prescription medication ketamine, the illicit xenobiotics PCP, MXE, and other novel PCP analogs, and the OTC medication DXM. The NMDA receptor antagonist most commonly abused by adolescents in the United States is DXM. These xenobiotics cause dissociative effects by non-competitively inhibiting the action of glutamate at the NMDA receptor. Additionally, these agents modulate the actions of monoamine neurotransmitters, agonize opioid receptors, and inhibit nitric oxide synthase. Patients typically present with sympathomimetic and neuropsychiatric clinical manifestations after abuse of NMDA receptor antagonists. Treatment is generally symptomatic and supportive. Interventions include benzodiazepines, propofol, fluids, antiemetics, aggressive cooling, and respiratory support.
[Mh] Termos MeSH primário: Drogas Desenhadas/efeitos adversos
Transtornos Relacionados ao Uso de Substâncias/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Transtornos Relacionados ao Uso de Anfetaminas/diagnóstico
Transtornos Relacionados ao Uso de Anfetaminas/terapia
Canabinoides/efeitos adversos
Estimulantes do Sistema Nervoso Central/efeitos adversos
Dextroanfetamina/efeitos adversos
Dextrometorfano/efeitos adversos
Antagonistas de Aminoácidos Excitatórios/efeitos adversos
Alucinógenos/efeitos adversos
Seres Humanos
Abuso de Inalantes/diagnóstico
Abuso de Inalantes/terapia
Ketamina/efeitos adversos
Metilfenidato/efeitos adversos
N-Metil-3,4-Metilenodioxianfetamina/efeitos adversos
Abuso de Fenciclidina/diagnóstico
Abuso de Fenciclidina/terapia
Receptores de N-Metil-D-Aspartato/antagonistas & inibidores
Transtornos Relacionados ao Uso de Substâncias/terapia
Xenobióticos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cannabinoids); 0 (Central Nervous System Stimulants); 0 (Designer Drugs); 0 (Excitatory Amino Acid Antagonists); 0 (Hallucinogens); 0 (Receptors, N-Methyl-D-Aspartate); 0 (Xenobiotics); 207ZZ9QZ49 (Methylphenidate); 690G0D6V8H (Ketamine); 7355X3ROTS (Dextromethorphan); KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine); TZ47U051FI (Dextroamphetamine)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160610
[Lr] Data última revisão:
160610
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160611
[St] Status:MEDLINE


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[PMID]:26295489
[Au] Autor:Bäckberg M; Beck O; Helander A
[Ad] Endereço:a Swedish Poisons Information Centre , Stockholm , Sweden.
[Ti] Título:Phencyclidine analog use in Sweden--intoxication cases involving 3-MeO-PCP and 4-MeO-PCP from the STRIDA project.
[So] Source:Clin Toxicol (Phila);53(9):856-64, 2015 Nov.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: 3-Methoxy-phencyclidine (3-MeO-PCP) and 4-methoxy-phencyclidine (4-MeO-PCP) are analogs of and drug substitutes for the dissociative substance PCP ("Angel dust"), a recreational drug that was most popular in the 1970s. In Sweden, use of methoxylated PCP analogs was noted starting in mid-2013, according to statistics from the Poisons Information Centre. The objective of this case series was to present clinical and bioanalytical data from analytically confirmed non-fatal intoxications associated with 3-MeO-PCP and/or 4-MeO-PCP within the STRIDA project. STUDY DESIGN: Observational case series of consecutive patients with self-reported or suspected exposure to new psychoactive substances (NPS) and who require hospital care. PATIENTS AND METHODS: Blood and urine samples were collected from intoxicated patients presenting at emergency departments (ED) or intensive care units (ICU) all over Sweden. NPS analysis was performed by multicomponent liquid chromatographic-tandem mass spectrometric (LC-MS/MS) and LC-high-resolution MS (LC-HRMS) methods. Data on clinical features were collected during Poisons Information Centre consultations and retrieved from medical records. RESULTS: The Poisons Information Centre registered its first call related to methoxylated PCP analogs in July 2013, while analytically confirmed cases first appeared in October 2013. From July 2013 to March 2015, 1243 cases of suspected NPS intoxication originating from ED or ICU were enrolled in the STRIDA project. During the 21-month period, 56 (4.5%) patients tested positive for 3-MeO-PCP and 11 (0.9%) for 4-MeO-PCP; 8 of these cases involved both substances. The 59 patients were aged 14-55 (median: 26) years and 51 (86%) were men. Co-exposure to other NPSs and/or classical drugs of abuse was common with only 7 cases (12%) indicated to be 3-MeO-PCP single-substance intoxications; prominent clinical signs seen in the latter cases were hypertension (systolic blood pressure ≥ 140 mmHg; 7 cases), tachycardia (≥ 100/min; 5 cases), and altered mental status (4 cases) including confusion, disorientation, dissociation, and/or hallucinations. Mixed-drug users displayed not only the same clinical features, but also more sympathomimetic effects including agitation (38%) and dilated pupils (33%). Patients testing positive for 3-/4-MeO-PCP were typically under medical care for 1-2 days (85%), and 37% of all cases were graded as severe intoxications (Poisoning Severity Score 3). Besides standard supportive therapy, 49% of the patients were treated with benzodiazepines and/or propofol. CONCLUSION: Laboratory analysis constitutes an important basis for the assessment of NPS hazard and availability. The adverse effects noted in cases of acute intoxications involving 3- and/or 4-MeO-PCP resembled those of other dissociatives such as PCP, ketamine, and methoxetamine. However, similar to intoxications involving other NPS, poly-substance use was found to be common.
[Mh] Termos MeSH primário: Abuso de Fenciclidina/epidemiologia
Fenciclidina/análogos & derivados
Fenciclidina/envenenamento
[Mh] Termos MeSH secundário: Adolescente
Adulto
Biomarcadores/sangue
Biomarcadores/urina
Cromatografia Líquida
Overdose de Drogas
Feminino
Hospitalização
Seres Humanos
Masculino
Meia-Idade
Fenciclidina/sangue
Fenciclidina/urina
Abuso de Fenciclidina/diagnóstico
Abuso de Fenciclidina/fisiopatologia
Abuso de Fenciclidina/terapia
Centros de Controle de Intoxicações
Valor Preditivo dos Testes
Índice de Gravidade de Doença
Detecção do Abuso de Substâncias/métodos
Suécia/epidemiologia
Espectrometria de Massas em Tandem
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (methoxydine); J1DOI7UV76 (Phencyclidine)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:151027
[Lr] Data última revisão:
151027
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:150822
[St] Status:MEDLINE
[do] DOI:10.3109/15563650.2015.1079325


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[PMID]:25502414
[Au] Autor:Dominici P; Kopec K; Manur R; Khalid A; Damiron K; Rowden A
[Ad] Endereço:Einstein Healthcare Network, Philadelphia, PA, USA, dominicip@gmail.com.
[Ti] Título:Phencyclidine Intoxication Case Series Study.
[So] Source:J Med Toxicol;11(3):321-5, 2015 Sep.
[Is] ISSN:1937-6995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Phencyclidine (PCP) is a synthetic compound derived from piperidine and used as an anesthetic and hallucinogenic. Little has been recently published regarding the clinical presentation of PCP intoxication. PCP use as a recreational drug is resurging. OBJECTIVE: Our objective was to describe clinical findings in patients presenting to the emergency department (ED) under the influence of PCP. METHODS: This was a case series study conducted at a tertiary care center with an annual census of 100,000 patients/year. Emergency physicians, residents, physician assistants, and research assistants identified patients with possible PCP intoxication. Self-reported PCP use, report by bystanders or Emergency Medical Services (EMS) staff, was used in this process. A structured data collection form was completed, documenting both clinical and behavioral events observed by the treating team during the ED visit. RESULTS: We collected data on 219 patients; 184 were analyzed; two patients were excluded secondary to incomplete data. The mean age of patients was 32.5 years (±7 years) with 65.2 % being males. PCP use was self-reported by 60.3 % of patients. Of the 184 patients, 153 (83.1 %) received a urine drug screen (UDS); 152 (98.7 %) were positive for PCP. On arrival, 78.3 % of patients were awake and alert, and 51.6 % were oriented to self, time/date, and place. Mean physiological parameters were the following: heart rate 101.1 bpm (±24.3), RR 18.9 bpm (±3.4), BP 146.3 (±19.4)/86.3 (±14.0) mmHg, 36.9° C (±0.5), and pulse oximetry 98.2 % (±1.9). Clinical findings were the following: retrograde amnesia in 46 (25 %), horizontal nystagmus in 118 (64.1 %), vertical nystagmus in 90 (48.9 %), hypertension in 87 (47.3 %), and agitation in 71 (38.6 %). Concomitant use of at least one other substance was reported by 99 (53.8 %) patients. The mean length of stay in the ED for all subjects was 261.1 (±172.8) minutes. Final disposition for 152 (82.6 %) patients was to home. Of the 184 patients, 14 (7.6 %) required admission; 12 were referred to Crisis Response Center. CONCLUSION: Patients with PCP intoxication tended to be young males. The prevalent clinical signs and symptoms were the following: retrograde amnesia, nystagmus, hypertension, and psychomotor agitation. Co-use of other substances was the norm. Most patients presenting to the ED with PCP intoxication do well and can be discharged home after a period of observation.
[Mh] Termos MeSH primário: Alucinógenos/envenenamento
Abuso de Fenciclidina/epidemiologia
Fenciclidina/envenenamento
[Mh] Termos MeSH secundário: Adulto
Serviço Hospitalar de Emergência
Feminino
Seres Humanos
Tempo de Internação
Masculino
Meia-Idade
Abuso de Fenciclidina/diagnóstico
Abuso de Fenciclidina/terapia
Philadelphia/epidemiologia
Prevalência
Fatores de Risco
Detecção do Abuso de Substâncias
Centros de Atenção Terciária
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hallucinogens); J1DOI7UV76 (Phencyclidine)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160901
[Lr] Data última revisão:
160901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141216
[St] Status:MEDLINE
[do] DOI:10.1007/s13181-014-0453-9


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[PMID]:25647855
[Au] Autor:Ali MM; Bahl K; Dross M; Farooqui S; Dross P
[Ti] Título:Accidental cell phone ingestion with pharyngeal impaction.
[So] Source:Del Med J;86(9):277-9, 2014 Sep.
[Is] ISSN:0011-7781
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: 35 year old intoxicated male ingested an unusual, large foreign object (cell phone). OBJECTIVE: To report the ingestion of an unusual large foreign object with hypopharyngeal impaction, complications, and treatment. DISCUSSION: Foreign body ingestion in the adult population is more prevalent in those who engage in drug or alcohol abuse. Impaction and perforation of the upper aerodigestive tract can lead to significant and potentially fatal complications including parapharyngeal/retropharyngeal abscess, mediastinitis, and aortoesophageal fistula. The treatment of foreign object ingestion is dependent on the type of foreign object ingested, its location, and potential for perforation. Endoscopic removal under general anesthesia is the treatment method recommended for foreign bodies impacted at the cricopharyngeus or esophagus. CONCLUSIONS: We report the only case of the accidental ingestion of an entire cell phone with casing. A plain film x-ray of the neck can be used in the assessment of the location of radiopaque foreign objects and in diagnosing potential complication.
[Mh] Termos MeSH primário: Telefone Celular
Corpos Estranhos/diagnóstico por imagem
Hipofaringe/lesões
[Mh] Termos MeSH secundário: Adulto
Corpos Estranhos/complicações
Corpos Estranhos/terapia
Seres Humanos
Hipofaringe/diagnóstico por imagem
Laringoscopia
Masculino
Abuso de Fenciclidina/complicações
Radiografia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1502
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150205
[St] Status:MEDLINE


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[PMID]:25377151
[Au] Autor:Zuccoli ML; Muscella A; Fucile C; Carrozzino R; Mattioli F; Martelli A; Orengo S
[Ad] Endereço:University of Genoa, Italy.
[Ti] Título:Paliperidone for the treatment of ketamine-induced psychosis: a case report.
[So] Source:Int J Psychiatry Med;48(2):103-8, 2014.
[Is] ISSN:0091-2174
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ketamine is an anaesthetic and analgesic drug synthesized in the 1960s from phencyclidine. The recreational use of ketamine increased among the dance culture of techno and house music, in particular in clubs, discotheques, and rave parties. The psychotropic effects of ketamine are now well known and they range from dissociation to positive, negative, and cognitive schizophrenia-like symptoms. We report a case of a chronic oral consumption of ketamine which induced agitation, behavioral abnormalities, and loss of contact with reality in a poly-drug abuser; these symptoms persisted more than two weeks after the drug consumption had stopped. Antipsychotic treatment with paliperidone led to a successful management of the psychosis, getting a complete resolution of the clinical picture. Paliperidone has proven to be very effective in the treatment of ketamine-induced disorders. Moreover, the pharmacological action and metabolism of paliperidone are poorly dependent from the activity of liver enzymes, so that it seems to be one of the best second generation antipsychotics for the treatment of smokers and alcohol abusers.
[Mh] Termos MeSH primário: Isoxazóis/administração & dosagem
Ketamina
Abuso de Fenciclidina
Fenciclidina/análogos & derivados
Psicoses Induzidas por Substâncias
Pirimidinas/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Anestésicos Dissociativos/efeitos adversos
Anestésicos Dissociativos/farmacologia
Antipsicóticos/administração & dosagem
Hospitalização
Seres Humanos
Ketamina/efeitos adversos
Ketamina/farmacologia
Masculino
Palmitato de Paliperidona
Abuso de Fenciclidina/complicações
Abuso de Fenciclidina/diagnóstico
Abuso de Fenciclidina/psicologia
Abuso de Fenciclidina/terapia
Escalas de Graduação Psiquiátrica
Psicoses Induzidas por Substâncias/diagnóstico
Psicoses Induzidas por Substâncias/etiologia
Psicoses Induzidas por Substâncias/psicologia
Psicoses Induzidas por Substâncias/terapia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Dissociative); 0 (Antipsychotic Agents); 0 (Isoxazoles); 0 (Pyrimidines); 690G0D6V8H (Ketamine); J1DOI7UV76 (Phencyclidine); R8P8USM8FR (Paliperidone Palmitate)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141108
[St] Status:MEDLINE
[do] DOI:10.2190/PM.48.2.c


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[PMID]:25093470
[Au] Autor:Fischer M; Unterecker S; Deckert J
[Ad] Endereço:Department of Psychiatry, Psychosomatics and Psychotherapy, Fuechsleinstr. 15, 97080, University of Wuerzburg, Wuerzburg, Germany Fischer_m2@klinik.uni-wuerzburg.de.
[Ti] Título:False-positive phencyclidine drug screenings during psychopharmacologic treatment.
[So] Source:J Clin Psychiatry;75(7):728-30, 2014 Jul.
[Is] ISSN:1555-2101
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Abuso de Fenciclidina/urina
Fenciclidina/urina
Detecção do Abuso de Substâncias/normas
[Mh] Termos MeSH secundário: Adulto
Reações Falso-Positivas
Seres Humanos
Detecção do Abuso de Substâncias/instrumentação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
J1DOI7UV76 (Phencyclidine)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:140806
[Lr] Data última revisão:
140806
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140806
[St] Status:MEDLINE
[do] DOI:10.4088/JCP.13cr08955


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[PMID]:24931864
[Au] Autor:Stevenson R; Tuddenham L
[Ad] Endereço:Emergency Department, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK. Electronic address: richard.stevenson@nhs.net.
[Ti] Título:Novel psychoactive substance intoxication resulting in attempted murder.
[So] Source:J Forensic Leg Med;25:60-1, 2014 Jul.
[Is] ISSN:1878-7487
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A man in his twenties who had no previous history of violence, snorted large quantities of two substances he identified as 3-methoxyphencyclidine (3-MeO-PCP), and methylenedioxypyrovalerone (MDPV); both are recognised as novel psychoactive substances, or commonly described in the media as "legal highs". He also inhaled butane gas. He experienced vivid hallucinations and developed bizarre ideas. During this state of mind he stabbed his father multiple times and was arrested and charged with attempted murder. He had a previous history of drug induced psychosis and although he had some slight residual symptoms before he consumed the substances, these were not considered relevant to his criminal liability at the time of the offence. The hallucinations caused by the use of these substances took six weeks to completely recede. He was convicted of attempted murder and sentenced to four years in prison.
[Mh] Termos MeSH primário: Alucinógenos/efeitos adversos
Homicídio/psicologia
Fenciclidina/efeitos adversos
Psicoses Induzidas por Substâncias/psicologia
Pirrolidinas/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Psiquiatria Legal
Toxicologia Forense
Alucinações/induzido quimicamente
Seres Humanos
Masculino
Abuso de Fenciclidina/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hallucinogens); 0 (Pyrrolidines); J1DOI7UV76 (Phencyclidine); VOU69C02JP (pyrovalerone)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:140616
[Lr] Data última revisão:
140616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140617
[St] Status:MEDLINE


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[PMID]:24501103
[Au] Autor:Pourmand A; Armstrong P; Mazer-Amirshahi M; Shokoohi H
[Ad] Endereço:Department of Emergency Medicine, Medical Center, George Washington University, Washington, DC, USA pourmand@gwu.edu.
[Ti] Título:The evolving high: new designer drugs of abuse.
[So] Source:Hum Exp Toxicol;33(10):993-9, 2014 Oct.
[Is] ISSN:1477-0903
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Over the past decade, emerging drugs of abuse and synthetic derivatives of more traditional agents have flooded the market. While Europe was the first to experience a surge in the use of drugs such as synthetic cathinones and cannabinoids, poison centers throughout the United States have seen a dramatic rise in calls related to these new designer drugs of abuse. In the majority of cases, care is largely supportive but significant medical and traumatic complications may occur. Providers must be aware of the ever-changing trends in abuse, so that they may optimally care for poisoned patients.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Anfetaminas/epidemiologia
Anfetaminas/envenenamento
Analgésicos Opioides/envenenamento
Drogas Desenhadas/envenenamento
Transtornos Relacionados ao Uso de Opioides/epidemiologia
Abuso de Fenciclidina/epidemiologia
Fenciclidina/envenenamento
[Mh] Termos MeSH secundário: Transtornos Relacionados ao Uso de Anfetaminas/diagnóstico
Transtornos Relacionados ao Uso de Anfetaminas/terapia
Anfetaminas/síntese química
Analgésicos Opioides/síntese química
Animais
Drogas Desenhadas/síntese química
Seres Humanos
Transtornos Relacionados ao Uso de Opioides/diagnóstico
Transtornos Relacionados ao Uso de Opioides/terapia
Fenciclidina/análogos & derivados
Fenciclidina/síntese química
Abuso de Fenciclidina/diagnóstico
Abuso de Fenciclidina/terapia
Envenenamento/epidemiologia
Envenenamento/terapia
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Amphetamines); 0 (Analgesics, Opioid); 0 (Designer Drugs); J1DOI7UV76 (Phencyclidine)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:141016
[Lr] Data última revisão:
141016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140207
[St] Status:MEDLINE
[do] DOI:10.1177/0960327113514100


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[PMID]:24345457
[Au] Autor:Aoyama Y; Mouri A; Toriumi K; Koseki T; Narusawa S; Ikawa N; Mamiya T; Nagai T; Yamada K; Nabeshima T
[Ad] Endereço:Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
[Ti] Título:Clozapine ameliorates epigenetic and behavioral abnormalities induced by phencyclidine through activation of dopamine D1 receptor.
[So] Source:Int J Neuropsychopharmacol;17(5):723-37, 2014 May.
[Is] ISSN:1469-5111
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Accumulating evidence suggests that dysregulation of histone modification is involved in the pathogenesis and/or pathophysiology of psychiatric disorders. However, the abnormalities in histone modification in the animal model of schizophrenia and the efficacy of antipsychotics for such abnormalities remain unclear. Here, we investigated the involvement of histone modification in phencyclidine-induced behavioral abnormalities and the effects of antipsychotics on these abnormalities. After repeated phencyclidine (10 mg/kg) treatment for 14 consecutive days, mice were treated with antipsychotics (clozapine or haloperidol) or the histone deacetylase inhibitor sodium butyrate for 7 d. Repeated phencyclidine treatments induced memory impairment and social deficit in the mice. The acetylation of histone H3 at lysine 9 residues decreased in the prefrontal cortex with phencyclidine treatment, whereas the expression level of histone deacetylase 5 increased. In addition, the phosphorylation of Ca²âº/calmodulin-dependent protein kinase II in the nucleus decreased in the prefrontal cortex of phencyclidine-treated mice. These behavioral and epigenetic changes in phencyclidine-treated mice were attenuated by clozapine and sodium butyrate but not by haloperidol. The dopamine D1 receptor antagonist SCH-23390 blocked the ameliorating effects of clozapine but not of sodium butyrate. Furthermore, clozapine and sodium butyrate attenuated the decrease in expression level of GABAergic system-related genes in the prefrontal cortex of phencyclidine-treated mice. These findings suggest that the antipsychotic effect of clozapine develops, at least in part, through epigenetic modification by activation of the dopamine D1 receptor in the prefrontal cortex.
[Mh] Termos MeSH primário: Antipsicóticos/farmacologia
Clozapina/farmacologia
Epigênese Genética/efeitos dos fármacos
Abuso de Fenciclidina/tratamento farmacológico
Córtex Pré-Frontal/efeitos dos fármacos
Receptores de Dopamina D1/metabolismo
[Mh] Termos MeSH secundário: Animais
Benzazepinas/farmacologia
Ácido Butírico/farmacologia
Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/metabolismo
Antagonistas de Dopamina/farmacologia
Comportamento Exploratório/efeitos dos fármacos
Alucinógenos/farmacologia
Haloperidol/farmacologia
Antagonistas dos Receptores Histamínicos/farmacologia
Histona Desacetilases/metabolismo
Histonas/metabolismo
Masculino
Transtornos da Memória/induzido quimicamente
Camundongos
Camundongos Endogâmicos ICR
Fenciclidina/farmacologia
Abuso de Fenciclidina/complicações
Abuso de Fenciclidina/metabolismo
Córtex Pré-Frontal/metabolismo
Receptores de Dopamina D1/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antipsychotic Agents); 0 (Benzazepines); 0 (Dopamine Antagonists); 0 (Hallucinogens); 0 (Histamine Antagonists); 0 (Histones); 0 (Receptors, Dopamine D1); 0 (SCH 23390); 107-92-6 (Butyric Acid); EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2); EC 3.5.1.98 (Hdac5 protein, mouse); EC 3.5.1.98 (Histone Deacetylases); J1DOI7UV76 (Phencyclidine); J60AR2IKIC (Clozapine); J6292F8L3D (Haloperidol)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:161020
[Lr] Data última revisão:
161020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131219
[St] Status:MEDLINE
[do] DOI:10.1017/S1461145713001466



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