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[PMID]:29323843
[Au] Autor:Borisevich IV; Chemikova NK; Markov VI; Krasnianskiy VP; Borisevich SV; Rozhdestvenskiy EV
[Ti] Título:An experience in the clinical use of specific immunoglobulin from horse blood serum for prophylaxis of Ebola haemorrhagic fever.
[So] Source:Vopr Virusol;62(1):25-9, 2017.
[Is] ISSN:0507-4088
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:The aim of this work was to estimate the efficacy and safety of single intramuscular introduction of specific heterologous immunoglobulin as prophylactic drug against Ebola hemorrhagic fever. Materials and methods. The specific heterologous immunoglobulin was introduced as a special prophylactic drug to 28 patients in epidemic situations, after skin hurt with infectious materials or contact with infectious blood. Clinico-laboratory observation was performed in 24 subjects after single intramuscular introduction of heterologous immunoglobulin Ebola. The samples of blood serum were investigated for immunoglobulin Ebola and antibodies to horse gamma-globulin on the 30th and 60th days after prophylaxis. Results. None of the subjects of the study contracted Ebola fever. There were no anaphylactic reactions after special prophylaxis with specific heterologous immunoglobulin. Among the subjects with normal allergic state 31% responded with local reactions; 13%, with a general reaction (mild case of the serum disease). Almost no reaction was observed in patients with unfavorable allergic state subjected to desensitizing therapy; in the absence of desensitizing therapy, 50% of patients with unfavorable allergic state exhibited local reactions; 17%, mild cases of the serum disease; 33%, moderate cases of the serum disease. In summary, if the tactics of immunoglobulin application was right, the quantity of local allergic reactions was 28%; of wide spread reactions, 6%. Weak serum disease was observed in 11% of the subjects. The prognostic period of resistance to Ebola fever was less than 30 days. Conclusion. The prophylactic use of specific immunoglobulin from horse blood serum against hemorrhagic Ebola fever is effective and relatively safe in patients subjected to desensitizing therapy.
[Mh] Termos MeSH primário: Anticorpos Antivirais/administração & dosagem
Ebolavirus/imunologia
Doença pelo Vírus Ebola/prevenção & controle
Imunoglobulina G/administração & dosagem
Profilaxia Pré-Exposição/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Animais
Anticorpos Antivirais/efeitos adversos
Anticorpos Antivirais/sangue
Criança
Busca de Comunicante
Dessensibilização Imunológica
Ebolavirus/patogenicidade
Feminino
Doença pelo Vírus Ebola/imunologia
Doença pelo Vírus Ebola/transmissão
Doença pelo Vírus Ebola/virologia
Cavalos/sangue
Cavalos/imunologia
Seres Humanos
Hipersensibilidade/imunologia
Hipersensibilidade/fisiopatologia
Imunização Passiva
Imunoglobulina G/efeitos adversos
Imunoglobulina G/sangue
Injeções Intramusculares
Masculino
Meia-Idade
Ferimentos Penetrantes Produzidos por Agulha/imunologia
Segurança do Paciente
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Immunoglobulin G)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE


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[PMID]:29190036
[Au] Autor:Reddy VK; Lavoie MC; Verbeek JH; Pahwa M
[Ad] Endereço:Cochrane Work Review Group, Finnish Institute of Occupational Health, Neulaniementie 4, Kuopio, Finland, 70101.
[Ti] Título:Devices for preventing percutaneous exposure injuries caused by needles in healthcare personnel.
[So] Source:Cochrane Database Syst Rev;11:CD009740, 2017 11 14.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Percutaneous exposure injuries from devices used for blood collection or for injections expose healthcare workers to the risk of blood borne infections such as hepatitis B and C, and human immunodeficiency virus (HIV). Safety features such as shields or retractable needles can possibly contribute to the prevention of these injuries and it is important to evaluate their effectiveness. OBJECTIVES: To determine the benefits and harms of safety medical devices aiming to prevent percutaneous exposure injuries caused by needles in healthcare personnel versus no intervention or alternative interventions. SEARCH METHODS: We searched CENTRAL, MEDLINE, EMBASE, NHSEED, Science Citation Index Expanded, CINAHL, Nioshtic, CISdoc and PsycINFO (until 11 November 2016). SELECTION CRITERIA: We included randomised controlled trials (RCT), controlled before and after studies (CBA) and interrupted time-series (ITS) designs of the effect of safety engineered medical devices on percutaneous exposure injuries in healthcare staff. DATA COLLECTION AND ANALYSIS: Two of the authors independently assessed study eligibility and risk of bias and extracted data. We synthesized study results with a fixed-effect or random-effects model meta-analysis where appropriate. MAIN RESULTS: We included six RCTs with 1838 participants, two cluster-RCTs with 795 participants and 73,454 patient days, five CBAs with approximately 22,000 participants and eleven ITS with an average of 13.8 data points. These studies evaluated safe modifications of blood collection systems, intravenous (IV) systems, injection systems, multiple devices, sharps containers and legislation on the implementation of safe devices. We estimated the needlestick injury (NSI) rate in the control groups to be about one to five NSIs per 1000 person-years. There were only two studies from low- or middle-income countries. The risk of bias was high in 20 of 24 studies. Safe blood collection systems:We found one RCT that found a safety engineered blood gas syringe having no considerable effect on NSIs (Relative Risk (RR) 0.2, 95% Confidence Interval (95% CI) 0.01 to 4.14, 550 patients, very low quality evidence). In one ITS study, safe blood collection systems decreased NSIs immediately after the introduction (effect size (ES) -6.9, 95% CI -9.5 to -4.2) but there was no further decrease over time (ES -1.2, 95% CI -2.5 to 0.1, very low quality evidence). Another ITS study evaluated an outdated recapping shield, which we did not consider further. Safe Intravenous systemsThere was very low quality evidence in two ITS studies that NSIs were reduced with the introduction of safe IV devices, whereas one RCT and one CBA study provided very low quality evidence of no effect. However, there was moderate quality evidence produced by four other RCT studies that these devices increased the number of blood splashes when the safety system had to be engaged actively (relative risk (RR) 1.6, 95% CI 1.08 to 2.36). In contrast there was low quality evidence produced by two RCTs of passive systems that showed no effect on blood splashes. Yet another RCT produced low quality evidence that a different safe active IV system also decreased the incidence of blood leakages. Safe injection devicesThere was very low quality evidence provided by one RCT and one CBA study showing that introduction of safe injection devices did not considerably change the NSI rate. One ITS study produced low quality evidence showing that the introduction of safe passive injection systems had no effect on NSI rate when compared to safe active injection systems. Multiple safe devicesThere was very low quality evidence from one CBA study and two ITS studies. According to the CBA study, the introduction of multiple safe devices resulted in a decrease in NSI,whereas the two ITS studies found no change. Safety containersOne CBA study produced very low quality evidence showing that the introduction of safety containers decreased NSI. However, two ITS studies evaluating the same intervention found inconsistent results. LegislationThere was low to moderate quality evidence in two ITS studies that introduction of legislation on the use of safety-engineered devices reduced the rate of NSIs among healthcare workers. There was also low quality evidence which showed a decrease in the trend over time for NSI rates.Twenty out of 24 studies had a high risk of bias and the lack of evidence of a beneficial effect could be due to both confounding and bias. This does not mean that these devices are not effective. AUTHORS' CONCLUSIONS: For safe blood collection systems, we found very low quality evidence of inconsistent effects on NSIs. For safe passive intravenous systems, we found very low quality evidence of a decrease in NSI and a reduction in the incidence of blood leakage events but moderate quality evidence that active systems may increase exposure to blood. For safe injection needles, the introduction of multiple safety devices or the introduction of sharps containers the evidence was inconsistent or there was no clear evidence of a benefit. There was low to moderate quality evidence that introduction of legislation probably reduces NSI rates.More high-quality cluster-randomised controlled studies that include cost-effectiveness measures are needed, especially in countries where both NSIs and blood-borne infections are highly prevalent.
[Mh] Termos MeSH primário: Coleta de Amostras Sanguíneas/instrumentação
Pessoal de Saúde
Ferimentos Penetrantes Produzidos por Agulha/prevenção & controle
Doenças Profissionais/prevenção & controle
Equipamentos de Proteção
[Mh] Termos MeSH secundário: Coleta de Amostras Sanguíneas/métodos
Estudos Controlados Antes e Depois
Seres Humanos
Infusões Intravenosas/instrumentação
Injeções/instrumentação
Ferimentos Penetrantes Produzidos por Agulha/epidemiologia
Doenças Profissionais/epidemiologia
Equipamento de Proteção Individual
Ensaios Clínicos Controlados Aleatórios como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD009740.pub3


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[PMID]:28865865
[Au] Autor:Brewer JD; Elston DM; Vidimos AT; Rizza SA; Miller SJ
[Ad] Endereço:Division of Dermatologic Surgery, Mayo Clinic, Rochester, Minnesota. Electronic address: brewer.jerry@mayo.edu.
[Ti] Título:Managing sharps injuries and other occupational exposures to HIV, HBV, and HCV in the dermatology office.
[So] Source:J Am Acad Dermatol;77(5):946-951.e6, 2017 Nov.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dermatologists and their staff are at risk for needlestick injuries and exposures to body fluids. Despite the availability of treatment to reduce the risk of blood-borne infection, many exposures go unreported. This paper identifies current recommendations and the specific details for response to occupational exposures to HIV, hepatitis B virus, and hepatitis C virus in the dermatology office. Issues surrounding each virus are discussed individually, and a summary step-by-step algorithm of how to proceed in the event of an occupational exposure is presented. In addition, a focused Practice Improvement Activity that is based on this paper and provides Maintenance of Certification credit has been developed. To view and participate, visit https://secure.dataharborsolutions.com/abdermorg/.
[Mh] Termos MeSH primário: Patógenos Transmitidos pelo Sangue
Transmissão de Doença Infecciosa do Paciente para o Profissional/prevenção & controle
Ferimentos Penetrantes Produzidos por Agulha/prevenção & controle
Exposição Ocupacional/efeitos adversos
Saúde do Trabalhador
[Mh] Termos MeSH secundário: Dermatologia
Infecções por HIV/transmissão
Hepacivirus/isolamento & purificação
Hepatite B/transmissão
Vírus da Hepatite B/isolamento & purificação
Hepatite C/transmissão
Seres Humanos
Masculino
Ferimentos Penetrantes Produzidos por Agulha/epidemiologia
Visita a Consultório Médico
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170904
[St] Status:MEDLINE


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[PMID]:28865631
[Au] Autor:Linzer PB; Clarke SP
[Ti] Título:An Integrative Review of the Hands-Free Technique in the OR.
[So] Source:AORN J;106(3):211-218.e6, 2017 Sep.
[Is] ISSN:1878-0369
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sharps injury rates are proportionally higher in perioperative areas than in other practice settings. The hands-free technique (HFT) has been shown to decrease the hazards of sharps injuries when passing sharps during surgery. We reviewed and synthesized research studies regarding compliance with the HFT and factors facilitating its use using a key word search of online databases and a secondary search of references. We reviewed English language studies published since 2001 regarding HFT compliance rates or related factors using the Johns Hopkins Nursing Evidence-Based Practice Model and Guidelines. We found 14 articles reporting a wide range of HFT compliance rates (ie, 5% to 84%), which identified that a number of organizational factors and health care workers' perceptions of infection risks influenced the use of the HFT.
[Mh] Termos MeSH primário: Prática Clínica Baseada em Evidências
Ferimentos Penetrantes Produzidos por Agulha/prevenção & controle
Traumatismos Ocupacionais/prevenção & controle
Salas Cirúrgicas
[Mh] Termos MeSH secundário: Bases de Dados Factuais
Pessoal de Saúde
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:170904
[St] Status:MEDLINE


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[PMID]:28683000
[Au] Autor:Markkanen P; Galligan C; Quinn M
[Ad] Endereço:Department of Public Health, University of Massachusetts Lowell, Lowell, Massachusetts (Drs Markkanen and Quinn); and Safe Home Care Project, University of Massachusetts Lowell, Lowell, Massachusetts (Ms Galligan). Pia Markkanen, ScD, is a research professor in the Department of Public Health at the University of Massachusetts Lowell in Lowell, Massachusetts. She is a coinvestigator on the National Institute for Occupational Safety and Health (NIOSH)-funded Safe Home Care Project and, earlier, Project SHARRP (Safe Home Care and Risk Reduction for Providers). Catherine Galligan, MSc, is a project manager and researcher for the NIOSH-funded Safe Home Care Project and, prior to that, Project SHARRP. She has written a workbook for hospitals on mercury reduction and selection of safer alternatives, articles on hazards associated with used medical sharps, and fact sheets on occupational safety and health topics. Margaret Quinn, ScD, CIH, is a professor in the Department of Public Health at the University of Massachusetts Lowell in Lowell, Massachusetts. She is the principal investigator of the NIOSH-funded Safe Home Care Project and, prior to that, Project SHARRP. She is also a member of NIOSH's National Occupational Research Agenda Healthcare and Social Assistance Council.
[Ti] Título:Safety Risks Among Home Infusion Nurses and Other Home Health Care Providers.
[So] Source:J Infus Nurs;40(4):215-223, 2017 Jul/Aug.
[Is] ISSN:1539-0667
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the United States, home health care (HHC) is a rapidly growing industry and home infusion therapy is a rapidly growing market. HHC can present substantial occupational safety and health (OSH) risks. This article summarizes major OSH risks relevant to home infusion therapy by illustrating them through real-life scenarios collected systematically using qualitative research methods by the National Institute for Occupational Safety and Health-funded research projects at the University of Massachusetts Lowell. The need for home infusion therapy will continue to grow in the future, and safety interventions to prevent or minimize OSH risks are essential.
[Mh] Termos MeSH primário: Serviços de Assistência Domiciliar/normas
Visitadores Domiciliares/utilização
Terapia por Infusões no Domicílio/enfermagem
[Mh] Termos MeSH secundário: Patógenos Transmitidos pelo Sangue
Grupos Focais
Terapia por Infusões no Domicílio/métodos
Seres Humanos
Ferimentos Penetrantes Produzidos por Agulha/prevenção & controle
Papel do Profissional de Enfermagem/psicologia
Exposição Ocupacional/prevenção & controle
Exposição Ocupacional/normas
Saúde do Trabalhador/normas
Pesquisa Qualitativa
Fatores de Risco
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1097/NAN.0000000000000227


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[PMID]:28556925
[Au] Autor:Rezaei S; Hajizadeh M; Zandian H; Fathi A; Nouri B
[Ad] Endereço:Assistant Professor, Research Center for Environmental Determinants of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
[Ti] Título:Period Prevalence and Reporting Rate of Needlestick Injuries to Nurses in Iran: A Systematic Review and Meta-Analysis.
[So] Source:Res Nurs Health;40(4):311-322, 2017 Aug.
[Is] ISSN:1098-240X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of this systematic review and meta-analysis was to provide a precise estimate of the period prevalence of needlestick injuries (NSI) among nurses working in hospitals in Iran and the reporting rate of NSI to nurse managers. We searched both international (PubMed, Scopus and the Institute for Scientific Information) and Iranian (Scientific Information Database, Iranmedex and Magiran) scientific databases to find studies published from 2000 to 2016 of NSI among Iranian nurses. The following keywords in Persian and English were used: "needle-stick" or "needle stick" or "needlestick," with and without "injury" or "injuries," "prevalence" or "frequency," "nurses" or "nursing staff," and "Iran." In a sample of 21 articles with 6,480 participants, we estimated that the overall 1-year period prevalence of NSI was 44% (95% confidence interval [CI], 35-53%) among Iranian nurses. The overall 1-year period prevalence of reporting NSI to nurse managers was 42% (95% CI, 33-52%). In meta-regression analysis, sample size, mean age, years of experience, and gender ratio were not associated with prevalence of NSI or reporting rate. The year of data collection was positively associated with period prevalence of NSI (p < .05), but not with the period prevalence of reporting NSI to nurse managers. Results indicated a high NSI period prevalence and low NSI reporting rate among nurses in Iran. Thus, effective interventions are required in hospitals in Iran to reduce the prevalence and increase the reporting rate of NSI. © 2017 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Acidentes de Trabalho/estatística & dados numéricos
Ferimentos Penetrantes Produzidos por Agulha/epidemiologia
Recursos Humanos de Enfermagem no Hospital/estatística & dados numéricos
Segurança/estatística & dados numéricos
Local de Trabalho/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Irã (Geográfico)/epidemiologia
Masculino
Meia-Idade
Prevalência
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE
[do] DOI:10.1002/nur.21801


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[PMID]:28545832
[Au] Autor:Karimi-Sari H; Alavian SM
[Ad] Endereço:Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran; Baqiyatallah Research Center for Gastroenterology and Liver Diseases (BRCGL), Baqiyatallah University of Medical Sciences, Tehran, Iran; Middle East Liver Diseases (MELD) Center, Tehran, Iran.
[Ti] Título:Needlestick injury against viral hepatitis elimination.
[So] Source:J Hosp Infect;96(4):398, 2017 08.
[Is] ISSN:1532-2939
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Hepatite C
Ferimentos Penetrantes Produzidos por Agulha
[Mh] Termos MeSH secundário: Hepatite B
Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170527
[St] Status:MEDLINE


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[PMID]:28445222
[Au] Autor:Arora G; Hoffman RM
[Ad] Endereço:G. Arora is assistant clinical professor, Department of Pediatrics, Division of Palliative Medicine, Children's Hospital Los Angeles, Keck School of Medicine of USC, Los Angeles, California. R.M. Hoffman is associate clinical professor, Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California.
[Ti] Título:Development of an HIV Postexposure Prophylaxis (PEP) Protocol for Trainees Engaging in Academic Global Health Experiences.
[So] Source:Acad Med;92(11):1574-1577, 2017 Nov.
[Is] ISSN:1938-808X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PROBLEM: Global health (GH) education programs have become increasingly common in U.S. medical schools and graduate medical education programs, with growing numbers of medical students, residents, and fellows participating in clinical experiences in settings with high HIV prevalence and limited resources. However, there are no guidelines for provision of HIV postexposure prophylaxis (PEP) to trainees engaging in these academic GH experiences. APPROACH: Faculty of the Global Health Education Programs (GHEP) at the David Geffen School of Medicine at UCLA and GH partner institutions recognized the need for PEP access for trainees engaged in GH experiences. In 2013-2014, key UCLA faculty collaborated in the development of the UCLA GHEP PEP Protocol, which includes provision of PEP medications to trainees prior to departure, an on-call infectious disease/HIV specialist to advise trainees who have exposures, and a system for following up with exposed trainees while on the GH rotation and after their return. OUTCOMES: Between February 2014 and September 2016, 112 medical students and 110 residents received education on the PEP protocol during their predeparture orientation. The protocol was used for 28 exposures (27 occupational, 1 nonoccupational), with PEP recommended in 3 occupational cases (all needlesticks) and the single nonoccupational case. There were no reported HIV seroconversions. NEXT STEPS: The authors plan to formally evaluate the PEP protocol, conduct a qualitative assessment with trainees and both UCLA and GH partner faculty, and discuss best practices with institutions across the United States and with GH partners.
[Mh] Termos MeSH primário: Fármacos Anti-HIV/uso terapêutico
Protocolos Clínicos
Infecções por HIV/prevenção & controle
Transmissão de Doença Infecciosa do Paciente para o Profissional/prevenção & controle
Ferimentos Penetrantes Produzidos por Agulha/tratamento farmacológico
Exposição Ocupacional
Profilaxia Pós-Exposição/organização & administração
[Mh] Termos MeSH secundário: Assistência ao Convalescente
Educação de Pós-Graduação em Medicina
Educação de Graduação em Medicina
Saúde Global
Seres Humanos
Internato e Residência
Corpo Clínico Hospitalar
Profilaxia Pós-Exposição/métodos
Estudantes de Medicina
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-HIV Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1097/ACM.0000000000001684


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[PMID]:28415945
[Au] Autor:Lu CW; Hao JL; Liu XF; Liang LL; Zhou DD
[Ad] Endereço:1 Department of Ophthalmology, the First Hospital of Jilin University, Changchun City, Jilin Province, China.
[Ti] Título:Pseudomonas aeruginosa endophthalmitis caused by accidental iatrogenic ocular injury with a hypodermic needle.
[So] Source:J Int Med Res;45(2):882-885, 2017 Apr.
[Is] ISSN:1473-2300
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Iatrogenic traumatic endophthalmitis is a rare but serious ocular infection that can lead to severe vision loss. A 44-year-old man presented with pain and decreased vision in the right eye 4 hours after injury with a hypodermic needle during irrigation of his eye. Slit-lamp examination revealed a penetrating corneal puncture and iris hole in the right eye. Twenty hours later, his visual acuity had decreased to hand motion, and severe fibrinoid uveitis was noted. He immediately underwent irrigation of the anterior chamber and intravitreal antibiotic injection. The right eye became painful again, and emergent vitrectomy combined with lensectomy was performed along with intravitreal antibiotic administration. The patient remained stable during the 2-month follow-up. Standard practice should be adopted when irrigating the eye to prevent this type of injury, and emergent surgical intervention is very important to preserve visual function.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Endoftalmite/diagnóstico
Ferimentos Penetrantes Produzidos por Agulha/diagnóstico
Infecções por Pseudomonas/diagnóstico
Uveíte/diagnóstico
Vitrectomia
[Mh] Termos MeSH secundário: Adulto
Endoftalmite/tratamento farmacológico
Endoftalmite/microbiologia
Endoftalmite/cirurgia
Olho/microbiologia
Olho/patologia
Seres Humanos
Doença Iatrogênica
Injeções Intravítreas
Masculino
Agulhas
Ferimentos Penetrantes Produzidos por Agulha/tratamento farmacológico
Ferimentos Penetrantes Produzidos por Agulha/microbiologia
Ferimentos Penetrantes Produzidos por Agulha/cirurgia
Infecções por Pseudomonas/tratamento farmacológico
Infecções por Pseudomonas/microbiologia
Infecções por Pseudomonas/cirurgia
Pseudomonas aeruginosa/crescimento & desenvolvimento
Pseudomonas aeruginosa/patogenicidade
Irrigação Terapêutica
Uveíte/tratamento farmacológico
Uveíte/microbiologia
Uveíte/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1177/0300060517694570


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[PMID]:28410412
[Au] Autor:Wallace JR; Mangas KM; Porter JL; Marcsisin R; Pidot SJ; Howden B; Omansen TF; Zeng W; Axford JK; Johnson PDR; Stinear TP
[Ad] Endereço:Department of Biology, Millersville University, Millersville, PA, United States of America.
[Ti] Título:Mycobacterium ulcerans low infectious dose and mechanical transmission support insect bites and puncturing injuries in the spread of Buruli ulcer.
[So] Source:PLoS Negl Trop Dis;11(4):e0005553, 2017 Apr.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Addressing the transmission enigma of the neglected disease Buruli ulcer (BU) is a World Health Organization priority. In Australia, we have observed an association between mosquitoes harboring the causative agent, Mycobacterium ulcerans, and BU. Here we tested a contaminated skin model of BU transmission by dipping the tails from healthy mice in cultures of the causative agent, Mycobacterium ulcerans. Tails were exposed to mosquito (Aedes notoscriptus and Aedes aegypti) blood feeding or punctured with sterile needles. Two of 12 of mice with M. ulcerans contaminated tails exposed to feeding A. notoscriptus mosquitoes developed BU. There were no mice exposed to A. aegypti that developed BU. Eighty-eight percent of mice (21/24) subjected to contaminated tail needle puncture developed BU. Mouse tails coated only in bacteria did not develop disease. A median incubation time of 12 weeks, consistent with data from human infections, was noted. We then specifically tested the M. ulcerans infectious dose-50 (ID50) in this contaminated skin surface infection model with needle puncture and observed an ID50 of 2.6 colony-forming units. We have uncovered a biologically plausible mechanical transmission mode of BU via natural or anthropogenic skin punctures.
[Mh] Termos MeSH primário: Úlcera de Buruli/transmissão
Mordeduras e Picadas de Insetos/complicações
Mycobacterium ulcerans/crescimento & desenvolvimento
Ferimentos Penetrantes Produzidos por Agulha/complicações
[Mh] Termos MeSH secundário: Aedes
Animais
Austrália
Feminino
Camundongos Endogâmicos BALB C
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005553



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