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Pesquisa : D01.029.260.093 [Categoria DeCS]
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[PMID]:29224767
[Au] Autor:Grønseth T; Vestby LK; Nesse LL; Thoen E; Habimana O; von Unge M; Silvola JT
[Ad] Endereço:University of Oslo, Oslo, Norway; Department of Otolaryngology, Head and Neck Surgery, Oslo University Hospital, Norway. Electronic address: t.gronseth@gmail.com.
[Ti] Título:Lugol's solution eradicates Staphylococcus aureus biofilm in vitro.
[So] Source:Int J Pediatr Otorhinolaryngol;103:58-64, 2017 Dec.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The aim of the study was to evaluate the antibacterial efficacy of Lugol's solution, acetic acid, and boric acid against Staphylococcus aureus biofilm. METHODS: The efficacy of Lugol's solution 1%, 0.1%, and 0.05%, acetic acid 5% or boric acid 4.7% for treatment of Staphylococcus aureus biofilm in vitro was tested using 30 clinical strains. Susceptibility in the planktonic state was assessed by disk diffusion test. Antiseptic effect on bacteria in biofilm was evaluated by using a Biofilm-oriented antiseptic test (BOAT) based on metabolic activity, a biofilm bactericidal test based on culturing of surviving bacteria and confocal laser scanning microscopy combined with LIVE/DEAD staining. RESULTS: In the planktonic state, all tested S. aureus strains were susceptible to Lugol's solution and acetic acid, while 27 out of 30 tested strains were susceptible to boric acid. In biofilm the metabolic activity was significantly reduced following exposure to Lugol's solution and 5% acetic acid, while boric acid exposure led to no significant changes in metabolic activities. In biofilm, biocidal activity was observed for Lugol's solution 1% (30/30), 0.1% (30/30), and 0.05% (26/30). Acetic acid and boric acid showed no bactericidal activity in this test. Confocal laser scanning microscopy, assessed in 4/30 strains, revealed significantly fewer viable biofilm bacteria with Lugol's solution (1% p < 0.001, 0.1% p = 0.001 or 0.05% p = 0.001), acetic acid 5% for 10 min (p = 0.001) or 30 min (p = 0.015), but not for acetic acid for 1 min or boric acid. CONCLUSION: Lugol's solution 1.0% and 0.1% effectively eradicated S. aureus in biofilm and could be an alternative to conventional topical antibiotics where S. aureus biofilm is suspected such as external otitis, pharyngitis and wounds.
[Mh] Termos MeSH primário: Ácido Acético/farmacologia
Anti-Infecciosos Locais/farmacologia
Biofilmes/efeitos dos fármacos
Ácidos Bóricos/farmacologia
Iodetos/farmacologia
Staphylococcus aureus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Microscopia Confocal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); 0 (Boric Acids); 0 (Iodides); Q40Q9N063P (Acetic Acid); R57ZHV85D4 (boric acid); T66M6Y3KSA (Lugol's solution)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


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[PMID]:29061819
[Au] Autor:Bai YC; Hsia YC; Lin YT; Chen KH; Chou FI; Yang CM; Chuang YJ
[Ad] Endereço:Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan, R.O.C.
[Ti] Título:Effect of Tumor Microenvironment on Selective Uptake of Boric Acid in HepG2 Human Hepatoma Cells.
[So] Source:Anticancer Res;37(11):6347-6353, 2017 11.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Feasibility and efficacy of boric acid (BA)-mediated boron neutron capture therapy (BNCT) was first demonstrated by eliminating hepatocellular carcinoma (HCC) in a rat model. Furthermore, selective uptake of BA by liver tumor cells was shown in a rabbit model. To gain further insight, this study aimed to investigate the mechanisms of transportation and selective uptake of BA in HepG2 liver tumor cells. MATERIALS AND METHODS: Transportation of BA in HepG2 cells was analyzed by time-course assays and by analyzing the rate of diffusion versus the concentration of BA. The effect of different tumor conditions on BA uptake was studied by treating HepG2 cells with 25 µg B/ml BA under different concentrations of glucose, at different pH and in the presence of water-soluble cholesterol. RESULTS: HepG2 cells mainly uptake BA by simple diffusion. Cell membrane permeability may also contribute to tumor-specific uptake of BA. CONCLUSION: The selective uptake of BA was achieved primarily by diffusion, while other factors, such as low pH and increased membrane fluidity, which are hallmarks of HCC, might further enhance BA uptake.
[Mh] Termos MeSH primário: Ácidos Bóricos/farmacocinética
Carcinoma Hepatocelular/metabolismo
Neoplasias Hepáticas/metabolismo
Microambiente Tumoral/efeitos da radiação
[Mh] Termos MeSH secundário: Ácidos Bóricos/farmacologia
Terapia por Captura de Nêutron de Boro
Carcinoma Hepatocelular/radioterapia
Membrana Celular/ultraestrutura
Colesterol/farmacologia
Glucose/farmacologia
Células Hep G2
Seres Humanos
Concentração de Íons de Hidrogênio
Neoplasias Hepáticas/radioterapia
Espectrofotometria Atômica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Boric Acids); 97C5T2UQ7J (Cholesterol); IY9XDZ35W2 (Glucose); R57ZHV85D4 (boric acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE


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[PMID]:28429621
[Au] Autor:Carlson JC; Rabito FA; Werthmann D; Fox M
[Ad] Endereço:1 Tulane University School of Medicine, New Orleans, LA, USA.
[Ti] Título:The Distribution and Movement of American Cockroaches in Urban Niches of New Orleans.
[So] Source:Clin Pediatr (Phila);56(11):1008-1012, 2017 Oct.
[Is] ISSN:1938-2707
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:American cockroaches are an important source of household allergens in tropical and semitropical climates. To determine which outdoor niches produce American cockroaches, traps were placed at 40 homes in New Orleans to collect nymphs. Nymphs were collected from the sewers, yards, and within the homes themselves. To compare sewers and yards as sources of cockroaches entering homes, adult cockroaches were collected, marked, and released into yards and sewers. No sewer-released cockroaches were collected in homes. Cockroaches released into yards were collected in the homes, suggesting that yards, rather than sewers, are a more important source niche. A field trial applying boric acid granules to the yard was performed in an effort to reduce entry of cockroaches. There was a significant reduction in the cockroach antigen collected in intervention homes compared with controls.
[Mh] Termos MeSH primário: Ácidos Bóricos
Inseticidas
Periplaneta
Controle de Pragas/métodos
[Mh] Termos MeSH secundário: Animais
Cidades
Drenagem Sanitária
Movimento
Nova Orleans
Ninfa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Boric Acids); 0 (Insecticides); R57ZHV85D4 (boric acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.1177/0009922817701169


  4 / 1195 MEDLINE  
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[PMID]:28387830
[Au] Autor:Lin CC; Chang TW; Chen HW; Shih CH; Hsu PC
[Ad] Endereço:Department of Biology, National Changhua University of Education, No. 1, Jin-De Rd., Changhua City, 50007, Taiwan.
[Ti] Título:Development of Liquid Bait With Unique Bait Station for Control of Dolichoderus thoracicus (Hymenoptera: Formicidae).
[So] Source:J Econ Entomol;110(4):1685-1692, 2017 Aug 01.
[Is] ISSN:1938-291X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The Dolichoderus thoracicus (Smith) has seriously infested urban, village, and agricultural environments in Taiwan. To develop optimal bait for the effective control of D. thoracicus, we investigated the feeding preferences of this ant at different sugar and amino acid concentrations in a laboratory setting. The number of feeding workers was significantly higher for 20% sucrose compared with that for other sugars at 10% and 20% concentrations. Furthermore, among all tested concentrations of monosodium glutamate (MSG; 1%, 3%, 5%, and 10%), the highest number of ants were attracted by 1% MSG with 20% sucrose. The consumption of each bait solution was also measured, and the results were similar to those for ant number. Regarding toxicants, the toxicity and repellency of 3% boric acid and borax bait were evaluated individually. Both 3% boric acid and borax demonstrated no repellency against D. thoracicus workers. The LT50 of the 3% boric acid bait was 4.87 d, whereas that of 3% borax bait was only 1.56 d. Thus, 3% boric acid showed further delayed action, facilitating workers spreading the toxicant to their nestmates through trophallaxis. In combination with our unique bait station, we propose an optimal bait formulation comprising 20% sucrose, 1% MSG, and 3% boric acid as a promising candidate for controlling D. thoracicus.
[Mh] Termos MeSH primário: Formigas/fisiologia
Metabolismo dos Carboidratos
Controle de Insetos
Inseticidas
Nitrogênio/metabolismo
Feromônios/farmacologia
[Mh] Termos MeSH secundário: Animais
Formigas/efeitos dos fármacos
Boratos
Ácidos Bóricos
Comportamento Alimentar/efeitos dos fármacos
Conservantes de Alimentos/metabolismo
Controle de Insetos/instrumentação
Taiwan
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Borates); 0 (Boric Acids); 0 (Food Preservatives); 0 (Insecticides); 0 (Pheromones); 0 (insect attractants); 1303-96-4 (borax); N762921K75 (Nitrogen); R57ZHV85D4 (boric acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170408
[St] Status:MEDLINE
[do] DOI:10.1093/jee/tox107


  5 / 1195 MEDLINE  
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[PMID]:28385795
[Au] Autor:O'Doherty J; Jauregui-Osoro M; Brothwood T; Szyszko T; Marsden PK; O'Doherty MJ; Cook GJR; Blower PJ; Lewington V
[Ad] Endereço:PET Imaging Centre, Division of Imaging Sciences and Biomedical Engineering, King's College London, St. Thomas' Hospital, London, United Kingdom; and.
[Ti] Título:F-Tetrafluoroborate, a PET Probe for Imaging Sodium/Iodide Symporter Expression: Whole-Body Biodistribution, Safety, and Radiation Dosimetry in Thyroid Cancer Patients.
[So] Source:J Nucl Med;58(10):1666-1671, 2017 Oct.
[Is] ISSN:1535-5667
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We report the safety, biodistribution, and internal radiation dosimetry, in humans with thyroid cancer, of F-tetrafluoroborate ( F-TFB), a novel PET radioligand for imaging the human sodium/iodide symporter (hNIS). Serial whole-body PET scans of 5 subjects with recently diagnosed thyroid cancer were acquired before surgery for up to 4 h after injection of 184 ± 15 MBq of F-TFB. Activity was determined in whole blood, plasma, and urine. Mean organ-absorbed doses and effective doses were calculated via quantitative image analysis and using OLINDA/EXM software. Images showed a high uptake of F-TFB in known areas of high hNIS expression (thyroid, salivary glands, and stomach). Excretion was predominantly renal. No adverse effects in relation to safety of the radiopharmaceutical were observed. The effective dose was 0.0326 ± 0.0018 mSv/MBq. The critical tissues/organs receiving the highest mean sex-averaged absorbed doses were the thyroid (0.135 ± 0.079 mSv/MBq), stomach (0.069 ± 0.022 mSv/MBq), and salivary glands (parotids, 0.031 ± 0.011 mSv/MBq; submandibular, 0.061 ± 0.031 mSv/MBq). Other organs of interest were the bladder (0.102 ± 0.046 mSv/MBq) and kidneys (0.029 ± 0.009 mSv/MBq). Imaging using F-TFB imparts a radiation exposure similar in magnitude to many other F-labeled radiotracers. F-TFB shows a biodistribution similar to Tc-pertechnetate, a known nonorganified hNIS tracer, and is pharmacologically and radiobiologically safe in humans. Phase 2 trials for F-TFB as an hNIS imaging agent are warranted.
[Mh] Termos MeSH primário: Boratos/farmacocinética
Ácidos Bóricos/farmacocinética
Regulação Neoplásica da Expressão Gênica
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos
Segurança
Simportadores/metabolismo
Neoplasias da Glândula Tireoide/diagnóstico por imagem
Neoplasias da Glândula Tireoide/metabolismo
[Mh] Termos MeSH secundário: Boratos/efeitos adversos
Boratos/metabolismo
Ácidos Bóricos/efeitos adversos
Ácidos Bóricos/metabolismo
Feminino
Seres Humanos
Masculino
Meia-Idade
Radiometria
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Borates); 0 (Boric Acids); 0 (Symporters); 0 (sodium-iodide symporter); H429WZ9FBQ (fluoroboric acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170408
[St] Status:MEDLINE
[do] DOI:10.2967/jnumed.117.192252


  6 / 1195 MEDLINE  
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[PMID]:28368904
[Au] Autor:Zhan H; Liang JF
[Ad] Endereço:Department of Biomedical Engineering, Chemistry, and Biological Sciences, Charles V. Schaefer School of Engineering and Sciences, Stevens Institute of Technology, Hoboken, New Jersey, USA.
[Ti] Título:Preparation and anticancer activity evaluation of an amorphous drug nanocomposite by simple heat treatment.
[So] Source:Anticancer Drugs;28(6):623-633, 2017 Jul.
[Is] ISSN:1473-5741
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The solubility of drug molecules is closely related to its bioactivity as it affects the dissolution rate and bioavailability, especially in the case of BCS IV drugs like camptothecin (CPT), a potential broad-spectrum anticancer agent. In this study, we construct a novel boric acid (BA)-coated CPT nanocomposite by means of a simple heat-treatment approach, which combines nanoscale size range and amorphous solid state together to improve the overall dissolution rate of CPT. This new CPT formulation showed a rod-like structure with nanoscale size and amorphous solid nature. These BA-coated CPT nanocomposites exhibited a dramatically improved dissolution rate, water dispersion property, and long-term chemical and physical stability. More importantly, the specific reactivity of BA groups to diols in the cell glycocalyx facilitated a rapid cross-membrane translocation of the drug nanocomposite, leading to efficient intracellular drug delivery. When tested on A549 cells and SKBR3 cells, this formulation demonstrated a much higher anticancer activity in comparison with free CPT, naked amorphous CPT nanoparticles, and control CPT nanocrystals. This formulation has great potential for clinical application; it is easy to scale up and be applied on other hydrophobic drugs.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Ácidos Bóricos/química
Ácidos Bóricos/farmacologia
Camptotecina/química
Camptotecina/farmacologia
Nanocompostos/química
[Mh] Termos MeSH secundário: Células A549
Antineoplásicos Fitogênicos/farmacocinética
Ácidos Bóricos/farmacocinética
Neoplasias da Mama/tratamento farmacológico
Neoplasias da Mama/metabolismo
Camptotecina/farmacocinética
Linhagem Celular Tumoral
Ensaios de Seleção de Medicamentos Antitumorais
Estabilidade de Medicamentos
Feminino
Seres Humanos
Neoplasias Pulmonares/tratamento farmacológico
Neoplasias Pulmonares/metabolismo
Nanocompostos/administração & dosagem
Solubilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Boric Acids); R57ZHV85D4 (boric acid); XT3Z54Z28A (Camptothecin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1097/CAD.0000000000000503


  7 / 1195 MEDLINE  
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[PMID]:28314961
[Au] Autor:Princz J; Becker L; Scheffczyk A; Stephenson G; Scroggins R; Moser T; Römbke J
[Ad] Endereço:Environment and Climate Change Canada, Biological Assessment and Standardization Section, 335 River Road, Ottawa, ON, K1A 0H3, Canada. Juliska.Princz@canada.ca.
[Ti] Título:Ecotoxicity of boric acid in standard laboratory tests with plants and soil organisms.
[So] Source:Ecotoxicology;26(4):471-481, 2017 May.
[Is] ISSN:1573-3017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To verify the continuous sensitivity of ecotoxicological tests (mainly the test organisms), reference substances with known toxicity are regularly tested. Ideally, this substance(s) would lack specificity in its mode action, be bioavailable and readily attainable with cost-effective means of chemical characterization. Boric acid has satisfied these criteria, but has most recently been characterized as a substance of very high concern, due to reproductive effects in humans, thus limiting its recommendation as an ideal reference toxicant. However, there is probably no other chemical for which ecotoxicity in soil has been so intensively studied; an extensive literature review yielded lethal (including avoidance) and sublethal data for 38 taxa. The ecotoxicity data were evaluated using species sensitivity distributions, collectively across all taxa, and separately according to species type, endpoints, soil type and duration. The lack of specificity in the mode of action yielded broad toxicity among soil taxa and soil types, and provided a collective approach to assessing species sensitivity, while taking into consideration differences in test methodologies and exposure durations. Toxicity was species-specific with Folsomia candida and enchytraied species demonstrating the most sensitivity; among plants, the following trend occurred: dicotyledonous (more sensitive) ≫ monocotyledonous ≫ gymnosperm species. Sensitivity was also time and endpoint specific, with endpoints such as lethality and avoidance being less sensitive than reproduction effects. Furthermore, given the breadth of data and toxicity demonstrated by boric acid, lessons learned from its evaluation are discussed to recommend the properties required by an ideal reference substance for the soil compartment.
[Mh] Termos MeSH primário: Ácidos Bóricos/toxicidade
Plantas/efeitos dos fármacos
Poluentes do Solo/toxicidade
Testes de Toxicidade
[Mh] Termos MeSH secundário: Animais
Artrópodes/efeitos dos fármacos
Ecotoxicologia
Solo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Boric Acids); 0 (Soil); 0 (Soil Pollutants); R57ZHV85D4 (boric acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170319
[St] Status:MEDLINE
[do] DOI:10.1007/s10646-017-1789-0


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[PMID]:28285642
[Au] Autor:Dogan A; Demirci S; Apdik H; Bayrak OF; Gulluoglu S; Tuysuz EC; Gusev O; Rizvanov AA; Nikerel E; Sahin F
[Ad] Endereço:Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Kayisdagi Cad. 26 Agustos Yerlesimi, 34755 Atasehir, Istanbul, Turkey; National Cancer Institute, CDBL, NIH, Frederick, MD.
[Ti] Título:A new hope for obesity management: Boron inhibits adipogenesis in progenitor cells through the Wnt/ß-catenin pathway.
[So] Source:Metabolism;69:130-142, 2017 Apr.
[Is] ISSN:1532-8600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Obesity is a worldwide medical problem resulting in serious morbidity and mortality involving differentiation of pre-adipocytes into mature adipocytes (adipogenesis). Boron treatment has been reported to be associated with weight reduction in experimental animals; however, its effects on pre-adipocyte differentiation and anti-adipogenic molecular mechanisms are unknown. In this study, we demonstrate the inhibitory activities of boric acid (BA) and sodium pentaborate pentahydrate (NaB) on adipogenesis using common cellular models. Boron treatment repressed the expression of adipogenesis-related genes and proteins, including CCAAT-enhancer-binding protein α and peroxisome proliferator-activated receptor γ, by regulating critical growth factors and the ß-catenin, AKT, and extracellular signal-regulated kinase signaling pathways. In addition, although boron treatment did not induce apoptosis in pre-adipocytes, it depressed mitotic clonal expansion by regulation of cell cycle genes. Overall, these data offer promising insights into the prevention/treatment of obesity and associated diseases.
[Mh] Termos MeSH primário: Adipogenia/efeitos dos fármacos
Fármacos Antiobesidade/uso terapêutico
Compostos de Boro/farmacologia
Obesidade/tratamento farmacológico
Células-Tronco/efeitos dos fármacos
Via de Sinalização Wnt/efeitos dos fármacos
[Mh] Termos MeSH secundário: Células 3T3-L1
Adipócitos/efeitos dos fármacos
Adipogenia/genética
Adiponectina/biossíntese
Adiponectina/genética
Animais
Boratos/farmacologia
Ácidos Bóricos/farmacologia
Diferenciação Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Citocinas/biossíntese
Citocinas/genética
Regulação da Expressão Gênica/efeitos dos fármacos
Genes cdc/efeitos dos fármacos
Leptina/biossíntese
Leptina/genética
Camundongos
Mitose/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adiponectin); 0 (Adipoq protein, mouse); 0 (Anti-Obesity Agents); 0 (Borates); 0 (Boric Acids); 0 (Boron Compounds); 0 (Cytokines); 0 (Leptin); 0 (sodium pentaborate); R57ZHV85D4 (boric acid)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE


  9 / 1195 MEDLINE  
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[PMID]:28177578
[Au] Autor:Milshtein JD; Fisher SL; Breault TM; Thompson LT; Brushett FR
[Ad] Endereço:Joint Center for Energy Storage Research, USA.
[Ti] Título:Feasibility of a Supporting-Salt-Free Nonaqueous Redox Flow Battery Utilizing Ionic Active Materials.
[So] Source:ChemSusChem;10(9):2080-2088, 2017 May 09.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Nonaqueous redox flow batteries (NAqRFBs) are promising devices for grid-scale energy storage, but high projected prices could limit commercial prospects. One route to reduced prices is to minimize or eliminate the expensive supporting salts typically employed in NAqRFBs. Herein, the feasibility of a flow cell operating in the absence of supporting salt by utilizing ionic active species is demonstrated. These ionic species have high conductivities in acetonitrile (12-19 mS cm ) and cycle at 20 mA cm with energy efficiencies (>75 %) comparable to those of state-of-the-art NAqRFBs employing high concentrations of supporting salt. A chemistry-agnostic techno-economic analysis highlights the possible cost savings of minimizing salt content in a NAqRFB. This work offers the first demonstration of a NAqRFB operating without supporting salt. The associated design principles can guide the development of future active species and could make NAqRFBs competitive with their aqueous counterparts.
[Mh] Termos MeSH primário: Fontes de Energia Elétrica
Íons
[Mh] Termos MeSH secundário: Acetonitrilos
Boratos
Ácidos Bóricos/química
Economia
Fontes de Energia Elétrica/economia
Eletrólitos
Desenho de Equipamento
Estudos de Viabilidade
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetonitriles); 0 (Borates); 0 (Boric Acids); 0 (Electrolytes); 0 (Ions); H429WZ9FBQ (fluoroboric acid); Z072SB282N (acetonitrile)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201700028


  10 / 1195 MEDLINE  
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[PMID]:28158885
[Au] Autor:Johnson K; Stollings JL; Ely EW
[Ad] Endereço:From the Lipscomb University College of Pharmacy, the Department of Pharmaceutical Services, Vanderbilt University Medical Center, and the Division of Allergy/Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Veterans Affairs Tennessee Valley, Geriatric Research Education Clinical Center (GRECC), Nashville, Tennessee.
[Ti] Título:Breaking Bad Delirium: Methamphetamine and Boric Acid Toxicity with Hallucinations and Pseudosepsis.
[So] Source:South Med J;110(2):138-141, 2017 Feb.
[Is] ISSN:1541-8243
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: A 30-year-old patient presented with hallucinations and profound shock. He was initially misdiagnosed as having severe sepsis; once ingestions were considered, he was diagnosed as potentially having arsenic toxicity. SUMMARY: The clinical story reveals many instructional lessons that could aid in the evaluation and management of future patients. This man presented with large amounts of blue crystals around his nose and lips from inhaling and eating boric acid (an ant poison) so he could, as he put it, kill the ants "pouring into my mouth and nose and up into my brain." His profound pseudosepsis and sustained delirium were induced by co-ingestion of methamphetamine and a large quantity of boric acid. Delirium is a form of acute brain dysfunction that often is multifactorial in critical illness and, when seen in septic shock, is associated with prolonged mechanical ventilation, increased length of hospital stay, medical costs, higher mortality, and long-term cognitive impairment resembling dementia. Pseudosepsis is a noninfectious condition most commonly seen with ingestions such as salicylate (aspirin) toxicity. CONCLUSIONS: This report emphasizes the need to recognize agents that contain boric acid as an etiology of unexplained delirium and profound shock.
[Mh] Termos MeSH primário: Ácidos Bóricos/toxicidade
Delírio
Alucinações
Metanfetamina/efeitos adversos
Choque Séptico/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Estimulantes do Sistema Nervoso Central/efeitos adversos
Delírio/induzido quimicamente
Delírio/diagnóstico
Delírio/terapia
Diagnóstico Diferencial
Gerenciamento Clínico
Alucinações/induzido quimicamente
Alucinações/diagnóstico
Alucinações/terapia
Seres Humanos
Inseticidas/toxicidade
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Boric Acids); 0 (Central Nervous System Stimulants); 0 (Insecticides); 44RAL3456C (Methamphetamine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.14423/SMJ.0000000000000599



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