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[PMID]:29381986
[Au] Autor:Yeh IJ; Liu KT
[Ad] Endereço:Department of Emergency Medicine, Kaohsiung Medical University Hospital.
[Ti] Título:ST segment elevation associated with hydrochloric acid ingestion: A case report.
[So] Source:Medicine (Baltimore);96(47):e8819, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Electrocardiography (ECG) was used to diagnose acute coronary syndrome, but many other diseases may also result in ST segment change. We report one case of ingested hydrochloric acid present with ST segment elevation in the ECG. However, subsequent coronary angiography did not reveal significant coronary occlusion. PATIENT CONCERNS: An 83-year-old female was transferred to our emergency department (ED) from the branch hospital due to ingestion of toilet bowl cleaner containing 9.5% hydrochloric acid. She complained about chest pain and 12-lead ECG showed ST segment elevation at lead II, III, and aVF. The blood examinations revealed elevation of aspartate transaminase (69 IU/L), thrombocytopenia (62,000/µL), and acidosis (pH 7.311, pCO2 27 mm Hg, HCO3 13.3 mmol/L). Creatine kinase-MB and troponin I did not elevate then. DIAGNOSES: After transferred to our ED, coronary angiography was done within 1 hour. Angiography showed 60% stenosis in the segment 7 of left anterior descending coronary artery and 30% nonsignificant stenosis in the segment 2 of right coronary artery, with no apical ballooning. No significant lesion consistent with ST segment elevation myocardial infarction was found. INTERVENTIONS: Conservative treatment was chosen. OUTCOMES: Bradycardia was followed by cardiac arrest that developed 4 hours later. Cardiopulmonary resuscitation was applied and the patient became shock status after return of spontaneous circulation. The patient was admitted to the intensive care unit and expired on next day. LESSONS: Patients of ingested hydrochloric acid present with ST segment elevation in the ECG may not indicate coronary artery disease. This ECG finding may be a poor prognostic index in such patients.
[Mh] Termos MeSH primário: Arritmias Cardíacas/induzido quimicamente
Detergentes/envenenamento
Ácido Clorídrico/envenenamento
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Bradicardia/induzido quimicamente
Evolução Fatal
Feminino
Parada Cardíaca/induzido quimicamente
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Detergents); QTT17582CB (Hydrochloric Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008819


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[PMID]:28817591
[Au] Autor:Oliveira GC; Tereza GPG; Boteon AP; Ferrairo BM; Gonçalves PSP; Silva TCD; Honório HM; Rios D
[Ad] Endereço:Department of Pediatric Dentistry, Orthodontics and Public Health Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.
[Ti] Título:Susceptibility of bovine dental enamel with initial erosion lesion to new erosive challenges.
[So] Source:PLoS One;12(8):e0182347, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This in vitro study evaluated the impact of initial erosion on the susceptibility of enamel to further erosive challenge. Thirty bovine enamel blocks were selected by surface hardness and randomized into two groups (n = 15): GC- group composed by enamel blocks without erosion lesion and GT- group composed by enamel blocks with initial erosion lesion. The baseline profile of each block was determined using the profilometer. The initial erosion was produced by immersing the blocks into HCl 0.01 M, pH 2.3 for 30 seconds, under stirring. The erosive cycling consisted of blocks immersion in hydrochloric acid (0.01 M, pH 2.3) for 2 minutes, followed by immersion in artificial saliva for 120 minutes. This procedure was repeated 4 times a day for 5 days, and the blocks were kept in artificial saliva overnight. After erosive cycling, final profile measurement was performed. Profilometry measured the enamel loss by the superposition of initial and final profiles. Data were analyzed by t-test (p<0.05). The result showed no statistically significant difference between groups (GS = 14.60±2.86 and GE = .14.69±2.21 µm). The presence of initial erosion on bovine dental enamel does not enhance its susceptibility to new erosive challenges.
[Mh] Termos MeSH primário: Esmalte Dentário/efeitos dos fármacos
Erosão Dentária/patologia
[Mh] Termos MeSH secundário: Animais
Bovinos
Esmalte Dentário/patologia
Ácido Clorídrico/farmacologia
Ácido Clorídrico/toxicidade
Erosão Dentária/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
QTT17582CB (Hydrochloric Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182347


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[PMID]:28700597
[Au] Autor:Fan W; Zhong Y; Qin M; Lin B; Chen F; Yan H; Li W; Lin J
[Ad] Endereço:Department of sericulture, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
[Ti] Título:Differentially expressed microRNAs in diapausing versus HCl-treated Bombyx embryos.
[So] Source:PLoS One;12(7):e0180085, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Differentially expressed microRNAs were detected to explore the molecular mechanisms of diapause termination. The total small RNA of diapause-destined silkworm eggs and HCl-treated eggs was extracted and then sequenced using HiSeq high-throughput method. 44 novel miRNAs were discovered. Compared to those in the diapause-destined eggs, 61 miRNAs showed significant changes in the acid-treated eggs, with 23 being up-regulated and 38 being down-regulated. The potential target genes of differentially expressed miRNAs were predicted by miRanda. Gene Ontology and KEGG pathway enrichment analysis of these potential target genes revealed that they were mainly located within cells and organelles, involved in cellular and metabolic processes, and participated in protein production, processing and transportation. Two differentially expressed genes, Bombyx mori SDH and Bmo-miR-2761-3p, were further analyzed with qRT-PCR. BmSDH was significantly up-regulated in the HCl-treated eggs, while Bmo-miR-2761-3p was down-regulated. These results suggested that these two genes were well coordinated in silkworm eggs. Dual luciferase reporter assay demonstrated that Bmo-miR-2761-3p inhibited the expression of BmSDH.
[Mh] Termos MeSH primário: Bombyx/genética
Ácido Clorídrico/farmacologia
MicroRNAs/genética
[Mh] Termos MeSH secundário: Animais
Bombyx/efeitos dos fármacos
Perfilação da Expressão Gênica
Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos
Regulação da Expressão Gênica no Desenvolvimento/genética
Ontologia Genética
Reação em Cadeia da Polimerase Via Transcriptase Reversa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MicroRNAs); QTT17582CB (Hydrochloric Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180085


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[PMID]:28690302
[Au] Autor:Tahara S; Yamamoto S; Yamajima Y; Miyakawa H; Uematsu Y; Monma K
[Ad] Endereço:Tokyo Metropolitan Institute of Public Health.
[Ti] Título:A Rapid Dialysis Method for Analysis of Artificial Sweeteners in Foods (2nd Report).
[So] Source:Shokuhin Eiseigaku Zasshi;58(3):124-131, 2017.
[Is] ISSN:1882-1006
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Following the previous report, a rapid dialysis method was developed for the extraction and purification of four artificial sweeteners, namely, sodium saccharide (Sa), acesulfame potassium (AK), aspartame (APM), and dulcin (Du), which are present in various foods. The method was evaluated by the addition of 0.02 g/kg of these sweeteners to a cookie sample, in the same manner as in the previous report. Revisions from the previous method were: reduction of the total dialysis volume from 200 to 100 mL, change of tube length from 55 to 50 cm, change of dialysate from 0.01 mol/L hydrochloric aqueous solution containing 10% sodium chloride to 30% methanol solution, and change of dialysis conditions from ambient temperature with occasional shaking to 50℃ with shaking at 160 rpm. As a result of these revisions, the recovery reached 99.3-103.8% with one hour dialysis. The obtained recovery yields were comparable to the recovery yields in the previous method with four hour dialysis.
[Mh] Termos MeSH primário: Aspartame/análise
Aspartame/isolamento & purificação
Diálise/métodos
Análise de Alimentos/métodos
Compostos de Fenilureia/análise
Compostos de Fenilureia/isolamento & purificação
Sacarina/análise
Sacarina/isolamento & purificação
Edulcorantes/análise
Edulcorantes/isolamento & purificação
Tiazinas/análise
Tiazinas/isolamento & purificação
[Mh] Termos MeSH secundário: Carbonato de Cálcio
Cromatografia Líquida de Alta Pressão
Citratos
Soluções para Diálise
Combinação de Medicamentos
Temperatura Alta
Ácido Clorídrico
Óxido de Magnésio
Metanol
Cloreto de Sódio
Fatores de Tempo
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Citrates); 0 (Dialysis Solutions); 0 (Drug Combinations); 0 (Phenylurea Compounds); 0 (Suby's G solution); 0 (Sweetening Agents); 0 (Thiazines); 059QF0KO0R (Water); 3A3U0GI71G (Magnesium Oxide); 451W47IQ8X (Sodium Chloride); 8U78KF577Z (dulcin); FST467XS7D (Saccharin); H0G9379FGK (Calcium Carbonate); MA3UYZ6K1H (acetosulfame); QTT17582CB (Hydrochloric Acid); Y4S76JWI15 (Methanol); Z0H242BBR1 (Aspartame)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.3358/shokueishi.58.124


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[PMID]:28674181
[Au] Autor:Lee H; Zhang D; Wu J; Otterbein LE; Jin Y
[Ad] Endereço:Division of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University, Boston, MA 02118; and.
[Ti] Título:Lung Epithelial Cell-Derived Microvesicles Regulate Macrophage Migration via MicroRNA-17/221-Induced Integrin ß Recycling.
[So] Source:J Immunol;199(4):1453-1464, 2017 Aug 15.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Robust lung inflammation is one of the prominent features in the pathogenesis of acute lung injury (ALI). Macrophage migration and recruitment are often seen at the early stage of lung inflammatory responses to noxious stimuli. Using an acid inhalation-induced lung injury model, we explored the mechanisms by which acid exposure initiates macrophage recruitment and migration during development of ALI. The lung epithelium comprises a large surface area and functions as a first-line defense against noxious insults. We found that acid exposure induced a remarkable microvesicle (MV) release from lung epithelium as detected in bronchoalveolar lavage fluid. Significantly elevated RNA, rather than protein, was found in these epithelium-derived MVs after acid and included several highly elevated microRNAs, including microRNA (miR)-17 and miR-221. Acid-induced epithelial MV release promoted macrophage migration in vitro and recruitment into the lung in vivo and required, in part, MV shuttling of miR-17 and/or miR-221. Mechanistically, acid-induced epithelial MV miR-17/221 promoted ß integrin recycling and presentation back onto the surface of macrophages, in part via a Rab11-mediated pathway. Integrin ß is known to play an essential role in regulating macrophage migration. Taken together, acid-induced ALI results in epithelial MV shuttling of miR-17/221 that in turn modulates macrophage ß integrin recycling, promoting macrophage recruitment and ultimately contributing to lung inflammation.
[Mh] Termos MeSH primário: Lesão Pulmonar Aguda/imunologia
Micropartículas Derivadas de Células
Integrina beta1/metabolismo
Pulmão/citologia
Macrófagos/fisiologia
MicroRNAs/metabolismo
[Mh] Termos MeSH secundário: Lesão Pulmonar Aguda/induzido quimicamente
Animais
Líquido da Lavagem Broncoalveolar/imunologia
Movimento Celular
Modelos Animais de Doenças
Células Epiteliais/imunologia
Células Epiteliais/fisiologia
Ácido Clorídrico/administração & dosagem
Inflamação/imunologia
Integrina beta1/imunologia
Pulmão/patologia
Pulmão/fisiologia
Macrófagos/imunologia
Camundongos
MicroRNAs/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Integrin beta1); 0 (MIRN221 microRNA, mouse); 0 (MicroRNAs); 0 (Mirn17 microRNA, mouse); QTT17582CB (Hydrochloric Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1700165


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[PMID]:28619729
[Au] Autor:Lang IM; Medda BK; Shaker R
[Ad] Endereço:Medical College of Wisconsin Dysphagia Institute, Division of Gastroenterology and Hepatology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin imlang@mcw.edu.
[Ti] Título:Characterization and mechanisms of the supragastric belch in the cat.
[So] Source:Am J Physiol Gastrointest Liver Physiol;313(3):G220-G229, 2017 Sep 01.
[Is] ISSN:1522-1547
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A response in which a belch occurs without gastric involvement, i.e., the supragastric belch (SGB), has been characterized in humans. The aims of this study were to determine whether animals have an SGB and, if so, to determine its mechanisms. Studies were conducted in decerebrate cats ( = 30) with electromyographic electrodes on hyoid, pharyngeal, esophageal, and diaphragm muscles. The effects of distending different regions of the esophagus in different manners using a balloon were quantified to determine the most appropriate stimulus for activating the cat SGB. The effects of esophageal perfusion of lidocaine ( = 3), vagus nerve transection ( = 3), or esophageal acidification ( = 5) on activation of the SGB were determined. Rapid large distensions of the thoracic esophagus best activated responses similar to the human SGB, i.e., rapid inhalation followed by a belch. The rapid inhalation was associated with activation of hiatal fibers and the belch with activation of dome fibers of the diaphragm. The rapid inhalation response was independent of the belch response. Lidocaine perfusion of the esophagus blocked the belch response without blocking the rapid inhalation, HCl perfusion sensitized the esophagus to activation of both the rapid inhalation and the belch response, and vagotomy blocked both responses. We conclude that the cat has an SGB that is composed of two independent reflex responses, i.e., rapid inhalation and belch, that are mediated by the vagus nerves and tension/mucosal receptors of the esophagus and sensitized by esophageal acid exposure. We hypothesize that the SGB is a learned voluntarily activated reflex response. Rapid strong distension of the thoracic esophagus activates rapid inhalation followed by a belch, which is the sequence of responses that compose the human supragastric belch (SGB). The rapid inhalation and belch phases of the cat SGB are activated by hiatal and dome fibers of the diaphragm, respectively, and are mediated by the vagus nerves and tension/mucosal receptors of the esophagus and sensitized by esophageal acid exposure. There are many similarities between the cat and human SGB.
[Mh] Termos MeSH primário: Gatos/fisiologia
Eructação/veterinária
Esôfago/fisiologia
[Mh] Termos MeSH secundário: Anestésicos Locais/farmacologia
Animais
Eructação/fisiopatologia
Esôfago/efeitos dos fármacos
Ácido Clorídrico
Concentração de Íons de Hidrogênio
Lidocaína/farmacologia
Vagotomia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Local); 98PI200987 (Lidocaine); QTT17582CB (Hydrochloric Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE
[do] DOI:10.1152/ajpgi.00142.2017


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[PMID]:28426799
[Au] Autor:Ligasová A; Konecný P; Frydrych I; Koberna K
[Ad] Endereço:Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University in Olomouc, Olomouc, Czech Republic.
[Ti] Título:Cell cycle profiling by image and flow cytometry: The optimised protocol for the detection of replicational activity using 5-Bromo-2'-deoxyuridine, low concentration of hydrochloric acid and exonuclease III.
[So] Source:PLoS One;12(4):e0175880, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The approach for the detection of replicational activity in cells using 5-bromo-2'-deoxyuridine, a low concentration of hydrochloric acid and exonuclease III is presented in the study. The described method was optimised with the aim to provide a fast and robust tool for the detection of DNA synthesis with minimal impact on the cellular structures using image and flow cytometry. The approach is based on the introduction of breaks into the DNA by the low concentration of hydrochloric acid followed by the subsequent enzymatic extension of these breaks using exonuclease III. Our data showed that the method has only a minimal effect on the tested protein localisations and is applicable both for formaldehyde- and ethanol-fixed cells. The approach partially also preserves the fluorescence of the fluorescent proteins in the HeLa cells expressing Fluorescent Ubiquitin Cell Cycle Indicator. In the case of the short labelling pulses that disabled the use of 5-ethynyl-2'-deoxyuridine because of the low specific signal, the described method provided a bright signal enabling reliable recognition of replicating cells. The optimized protocol was also successfully tested for the detection of trifluridine, the nucleoside used as an antiviral drug and in combination with tipiracil also for the treatment of some types of cancer.
[Mh] Termos MeSH primário: Bromodesoxiuridina/metabolismo
Ciclo Celular
Exodesoxirribonucleases/metabolismo
Ácido Clorídrico/farmacologia
[Mh] Termos MeSH secundário: Células A549
Citometria de Fluxo
Células HeLa
Seres Humanos
Microscopia de Fluorescência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.1.- (Exodeoxyribonucleases); EC 3.1.11.2 (exodeoxyribonuclease III); G34N38R2N1 (Bromodeoxyuridine); QTT17582CB (Hydrochloric Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175880


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[PMID]:28406755
[Au] Autor:Cissell DD; Link JM; Hu JC; Athanasiou KA
[Ad] Endereço:1 Department of Surgical and Radiological Sciences, University of California , Davis, California.
[Ti] Título:A Modified Hydroxyproline Assay Based on Hydrochloric Acid in Ehrlich's Solution Accurately Measures Tissue Collagen Content.
[So] Source:Tissue Eng Part C Methods;23(4):243-250, 2017 04.
[Is] ISSN:1937-3392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Collagen quantification has long been relevant to biomedical research and clinical practice to characterize tissues and determine disease states. The hydroxyproline assay, while a broadly employed method of quantifying collagen, uses perchloric acid to dissolve Ehrlich's reagent. Since perchloric acid poses occupational safety hazards and high costs, in this study, a new hydroxyproline assay was developed that replaces perchloric acid with a relatively safer and cheaper alternative, hydrochloric acid (HCl). To validate this biochemical technique, first, using either acid to dissolve Ehrlich's reagent, the assays were completed for native and engineered collagenous tissues. No statistical differences were identified between the assays (p = 0.32). Subsequently, both biochemical techniques were compared to amino acid analysis, considered a proteomics gold standard. Interestingly, utilizing HCl in lieu of perchloric acid yielded greater concordance with amino acid analysis (ρ = 0.980) than did the traditional assay (ρ = 0.947); that is, the HCl-based assay more closely estimates hydroxyproline content, and, consequently, true collagen content. Thus, using Ehrlich's reagent containing HCl in the hydroxyproline assay represents an advance in both mitigating laboratory safety hazards and improving biochemical collagen quantification.
[Mh] Termos MeSH primário: Benzaldeídos/química
Colágeno/química
Ácido Clorídrico/química
Hidroxiprolina/análise
[Mh] Termos MeSH secundário: Animais
Bovinos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzaldehydes); 9007-34-5 (Collagen); QTT17582CB (Hydrochloric Acid); RMB44WO89X (Hydroxyproline); V7E88PR1YB (p-dimethylaminobenzaldehyde)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1089/ten.tec.2017.0018


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[PMID]:28350832
[Au] Autor:Wang H; Liu T; Feng S; Zhang W
[Ad] Endereço:School of Environmental Science and Engineering, South University of Science and Technology of China, Shenzhen, P. R. China.
[Ti] Título:Metal removal and associated binding fraction transformation in contaminated river sediment washed by different types of agents.
[So] Source:PLoS One;12(3):e0174571, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In ex-situ washing, HCl, EDTA and H2O2 solutions can effectively extract heavy metals in river sediment. Nevertheless they often target different sediment components, possibly transforming metal species into more bioavailable and hence toxic ones. This study, in batch settings, investigated the influences of different types of washing agents (i.e. HCl, EDTA and H2O2) on metal (i.e. Cu and Zn) removal from contaminated river sediment, destroy or dissolution of sediment components, and transformation of metal fractions during chemical washing treatment. Additionally, bioavailability of these metals left in the washed sediment was assessed. Results showed that HCl obtained the highest Cu and Zn removal through destroying the reducible, oxidizable and residual sediment components. Meanwhile, it transformed metal fractions to acid extractable one, resulting in an increase in metal bioavailability. Thus, the feasibility of washing with HCl for sediment remediation shall be reconsidered due to the caused high metal bioavailability. EDTA was capable of removing metals via direct complexation of labile metal species and indirect dissolution of reducible and oxidizable sediment components, where the transformation of corresponding metal binding fraction may occur. H2O2 obtained the lowest total Cu and Zn removal, but it preferentially removed the oxidizable metal species by oxidizing sulfides in the sediment. The bioavailable levels of Cu and Zn in the sediment washed by EDTA or H2O2 seemed not increase. To maintain a good balance between labile metal species removal and avoiding increase of metal bioavailability, EDTA and H2O2 are promising additives for metal removal by sediment washing.
[Mh] Termos MeSH primário: Recuperação e Remediação Ambiental/métodos
Sedimentos Geológicos/química
Metais Pesados/análise
Rios/química
Poluentes da Água/análise
[Mh] Termos MeSH secundário: China
Cobre/análise
Cobre/isolamento & purificação
Ácido Edético/química
Ácido Edético/farmacologia
Geografia
Sedimentos Geológicos/análise
Ácido Clorídrico/química
Ácido Clorídrico/farmacologia
Peróxido de Hidrogênio/química
Peróxido de Hidrogênio/farmacologia
Metais Pesados/isolamento & purificação
Microscopia Eletrônica de Varredura
Reprodutibilidade dos Testes
Espectrometria por Raios X
Poluentes da Água/isolamento & purificação
Poluição da Água/prevenção & controle
Difração de Raios X
Zinco/análise
Zinco/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy); 0 (Water Pollutants); 789U1901C5 (Copper); 9G34HU7RV0 (Edetic Acid); BBX060AN9V (Hydrogen Peroxide); J41CSQ7QDS (Zinc); QTT17582CB (Hydrochloric Acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170329
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174571


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[PMID]:28344174
[Au] Autor:Jia D; Gao Y; Williams GR
[Ad] Endereço:UCL School of Pharmacy, University College London, London WC1N 1AX, UK.
[Ti] Título:Core/shell poly(ethylene oxide)/Eudragit fibers for site-specific release.
[So] Source:Int J Pharm;523(1):376-385, 2017 May 15.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Electrospinning was used to prepare core/shell fibers containing the active pharmaceutical ingredients indomethacin (IMC) or mebeverine hydrochloride (MB-HCl). The shell of the fibers was fabricated from the pH sensitive Eudragit S100 polymer, while the drug-loaded core was based on the mucoadhesive poly(ethylene oxide) (PEO). Three different drug loadings (from 9 to 23% (w/w) of the core mass) were prepared, and for MB-HCl two different molecular weights of PEO were explored. The resultant fibers generally comprise smooth cylinders, although in some cases defects such as surface particles or flattened or merged fibers were visible. Transmission electron microscopy showed all the systems to have clear core and shell compartments. The drugs are present in the amorphous physical form in the fibers. Dissolution tests found that the fibers can effectively prevent release in acidic conditions representative of the stomach, particularly for the acidic indomethacin. After transfer to a pH 7.4 medium, sustained release over between 6 and 22h is observed. Given the mucoadhesive nature of the PEO core, after dissolution of the shell the fibers will be able to adhere to the walls of the intestinal tract and give sustained local drug release. This renders them promising for the treatment of conditions such as irritable bowel disease and colon cancer.
[Mh] Termos MeSH primário: Sistemas de Liberação de Medicamentos
Polietilenoglicóis/química
Ácidos Polimetacrílicos/química
[Mh] Termos MeSH secundário: Colo
Preparações de Ação Retardada/química
Liberação Controlada de Fármacos
Ácido Clorídrico/química
Indometacina/química
Microscopia Eletrônica de Varredura
Microscopia Eletrônica de Transmissão
Fenetilaminas/química
Tecnologia Farmacêutica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Delayed-Action Preparations); 0 (Phenethylamines); 0 (Polymethacrylic Acids); 25086-15-1 (methylmethacrylate-methacrylic acid copolymer); 30IQX730WE (Polyethylene Glycols); 7F80CC3NNV (mebeverine); QTT17582CB (Hydrochloric Acid); XXE1CET956 (Indomethacin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE



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