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[PMID]:28767959
[Au] Autor:Zacarias CH; Esteban C; Rodrigues GL; Nascimento ES
[Ad] Endereço:Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brasil.
[Ti] Título:Occupational exposure to hydrogen cyanide during large-scale cassava processing, in Alagoas State, Brazil.
[So] Source:Cad Saude Publica;33(7):e00073416, 2017 Jul 27.
[Is] ISSN:1678-4464
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The cassava roots used for flour production contain high amounts of cyanogenic glycosides and are, therefore, potential hydrogen cyanide (HCN) releasers. This fact is the cause of an increasing health concern in the sector of cassava processing. Brazilian workers engaged in the flour production may be chronically exposed to HCN in levels above the safety limits. This hypothesis is based on the drastic reduction in cyanide content of cassava roots during a traditional Brazilian method of processing and in the physical properties of the compound, which makes it very susceptible to volatilization and air contamination. As an attempt to explore this issue, HCN exposure in Brazilian "flour houses" was evaluated in this study through environmental and biological monitoring. Four flour houses placed in Alagoas State, Brazil, were investigated. The results indicated that the cassava processors are chronically exposed to HCN at average levels between 0.464 and 3.328mg/m3 (TWA), in the work environment. This range is below the TLV-C of 5mg/m3 but not below the Action Level of 2.5mg/m3. These data may be interpreted as a possible risk to susceptible individuals. Additionally, the biological monitoring indicated a high cyanide exposure in the population study, considering urinary thiocyanate (SCN-) levels.
[Mh] Termos MeSH primário: Indústria de Processamento de Alimentos/estatística & dados numéricos
Cianeto de Hidrogênio/análise
Manihot/química
Exposição Ocupacional/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Brasil
Monitoramento Ambiental/métodos
Farinha
Seres Humanos
Cianeto de Hidrogênio/toxicidade
Masculino
Exposição Ocupacional/efeitos adversos
Valores de Referência
Medição de Risco
Fatores de Risco
Fatores de Tempo
Local de Trabalho
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
2WTB3V159F (Hydrogen Cyanide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


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[PMID]:28484804
[Au] Autor:Rani R; Kumar V
[Ad] Endereço:Laboratory of Applied Microbiology, Department of Environmental Science and Engineering, Indian Institute of Technology (Indian School of Mines), Dhanbad, Jharkhand, 826 004, India.
[Ti] Título:Endosulfan Degradation by Selected Strains of Plant Growth Promoting Rhizobacteria.
[So] Source:Bull Environ Contam Toxicol;99(1):138-145, 2017 Jul.
[Is] ISSN:1432-0800
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sixty endosulfan tolerant bacterial strains were isolated from pesticide stressed agricultural soils. Five most tolerant strains were tested for plant growth promoting (PGP) activities and endosulfan degradation under different optimizing conditions in broth and soil. The strains PRB101 and PRB77 were the most efficient in terms of endosulfan degradation and PGP activities and showed solubilization indexes of 3.3 and 3.1 mm, indole acetic acid production of 71 and 68 µg mL , siderophore zones of 13 mm each at the recommended dosage, respectively. Hydrogen cyanide and ammonia production remained unaffected in the presence of endosulfan. PRB101 and PRB77 strains were able to degrade 74% and 70% of endosulfan in broth and 67% and 63% in soil, respectively. Based on 16S rDNA analysis, the strains PRB101 and PRB77 exhibited 99% homology with Bacillus sp. KF984414 and Bacillus sp. LN849696, respectively.
[Mh] Termos MeSH primário: Biodegradação Ambiental
Endossulfano/metabolismo
Praguicidas/metabolismo
Microbiologia do Solo
Poluentes do Solo/metabolismo
[Mh] Termos MeSH secundário: Agricultura
Amônia
Bacillus/metabolismo
Cianeto de Hidrogênio
Ácidos Indolacéticos
Desenvolvimento Vegetal
Sideróforos
Solo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Indoleacetic Acids); 0 (Pesticides); 0 (Siderophores); 0 (Soil); 0 (Soil Pollutants); 2WTB3V159F (Hydrogen Cyanide); 6U1S09C61L (indoleacetic acid); 7664-41-7 (Ammonia); OKA6A6ZD4K (Endosulfan)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.1007/s00128-017-2102-x


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[PMID]:28358818
[Au] Autor:Ossowicki A; Jafra S; Garbeva P
[Ad] Endereço:Laboratory of Biological Plant Protection, Department of Biotechnology, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, Gdansk, Poland.
[Ti] Título:The antimicrobial volatile power of the rhizospheric isolate Pseudomonas donghuensis P482.
[So] Source:PLoS One;12(3):e0174362, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Soil and rhizosphere bacteria produce an array of secondary metabolites including a wide range of volatile organic compounds (VOCs). These compounds play an important role in the long-distance interactions and communication between (micro)organisms. Furthermore, bacterial VOCs are involved in plant pathogens inhibition and induction of soil fungistasis and suppressivenes. In the present study, we analysed the volatile blend emitted by the rhizospheric isolate Pseudomonas donghuensis P482 and evaluated the volatile effect on the plant pathogenic fungi and bacteria as well as one oomycete. Moreover, we investigated the role of the GacS/GacA system on VOCs production in P. donghuensis P482. The results obtained demonstrated that VOCs emitted by P. donghuensis P482 have strong antifungal and antioomycete, but not antibacterial activity. The production of certain volatiles such as dimethyl sulfide, S-methyl thioacetate, methyl thiocyanate, dimethyl trisulfide, 1-undecan and HCN is depended on the GacS/GacA two-component regulatory system. Apparently, these compounds play an important role in the pathogens suppression as the gacA mutant entirely lost the ability to inhibit via volatiles the growth of tested plant pathogens.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Pseudomonas/metabolismo
Compostos Orgânicos Voláteis/farmacologia
[Mh] Termos MeSH secundário: Agrobacterium/efeitos dos fármacos
Anti-Infecciosos/química
Antifúngicos/química
Antifúngicos/farmacologia
Proteínas de Bactérias/metabolismo
Fungos/efeitos dos fármacos
Fusarium/efeitos dos fármacos
Cromatografia Gasosa-Espectrometria de Massas
Cianeto de Hidrogênio/metabolismo
Oomicetos/efeitos dos fármacos
Pseudomonas fluorescens/efeitos dos fármacos
Pythium/efeitos dos fármacos
Rhizoctonia/efeitos dos fármacos
Compostos Orgânicos Voláteis/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antifungal Agents); 0 (Bacterial Proteins); 0 (Volatile Organic Compounds); 2WTB3V159F (Hydrogen Cyanide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174362


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[PMID]:27938859
[Au] Autor:Rijavec T; Lapanje A
[Ad] Endereço:Institute of Metagenomics and Microbial Technologies, Clevelandska ulica 19, 1000 Ljubljana, Slovenia; Department of Environmental Sciences, Jozef Stefan Institute, Jamova cesta 39, 1000 Ljubljana, Slovenia. Electronic address: tomaz.research@gmail.com.
[Ti] Título:Cyanogenic Pseudomonas spp. strains are concentrated in the rhizosphere of alpine pioneer plants.
[So] Source:Microbiol Res;194:20-28, 2017 Jan.
[Is] ISSN:1618-0623
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:HCN producing bacteria have previously been isolated from alpine mineral soil and their ecophysiology was presumed to be associated with mineral weathering. Nevertheless, the high ecological patchiness of the alpine environment calls for an extensive and detailed analysis of the spatial distribution of HCN producing bacterial populations and their associated weathering traits. Our results of such an analysis showed that primarily the rhizosphere of pioneer plants was rich in HPPs, harbouring the most potent HCN producers. HCN production incidence and intensity were dependent on the plant-associated microhabitat and type of bedrock/mineral soil, however the HCN+ phenotype was not associated with one of the particular genotypes which we determined by BOX-PCR. In HPP isolates, HCN production most commonly co-occurred with the production of hydroxamate-type siderophores, but was less often associated with inorganic phosphate solubilization activity and the production of catechol-type siderophores. These observations indicate that a plant's physiotype, not species, provide physicochemical conditions that determine selective pressure, which enables the growth of Pseudomonas spp. with a random genotype, but phenotypically predetermined to increase mineral weathering via a particular combination of phosphate solubilization and iron complexation with siderophores and HCN.
[Mh] Termos MeSH primário: Cianeto de Hidrogênio/metabolismo
Raízes de Plantas/microbiologia
Plantas/microbiologia
Pseudomonas/metabolismo
Rizosfera
[Mh] Termos MeSH secundário: DNA Bacteriano/genética
DNA Bacteriano/isolamento & purificação
Ecossistema
Genótipo
Cianeto de Hidrogênio/química
Ferro/química
Ferro/metabolismo
Oligopeptídeos/metabolismo
Fenótipo
Fosfatos/química
Fosfatos/metabolismo
Filogenia
Reação em Cadeia da Polimerase/métodos
Pseudomonas/citologia
Pseudomonas/genética
Pseudomonas/isolamento & purificação
Rhizobium/classificação
Rhizobium/genética
Rhizobium/isolamento & purificação
Rhizobium/metabolismo
Sideróforos/química
Sideróforos/metabolismo
Solo/química
Microbiologia do Solo
Suíça
Tundra
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Oligopeptides); 0 (Phosphates); 0 (Siderophores); 0 (Soil); 2WTB3V159F (Hydrogen Cyanide); 8062-00-8 (pyoverdin); E1UOL152H7 (Iron)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


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[PMID]:27518115
[Au] Autor:Marín-Yaseli MR; Cid C; Yagüe AI; Ruiz-Bermejo M
[Ad] Endereço:Dpto. Evolución Molecular, Centro de Astrobilogía (INTA-CSIC), Ctra. Torrejón-Ajalvir, km 4.2, Torrejón de Ardoz, ES-28850, Madrid.
[Ti] Título:Detection of Macromolecular Fractions in HCN Polymers Using Electrophoretic and Ultrafiltration Techniques.
[So] Source:Chem Biodivers;14(2), 2017 Feb.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Elucidating the origin of life involves synthetic as well as analytical challenges. Herein, for the first time, we describe the use of gel electrophoresis and ultrafiltration to fractionate HCN polymers. Since the first prebiotic synthesis of adenine by Oró, HCN polymers have gained much interest in studies on the origins of life due to the identification of biomonomers and related compounds within them. Here, we demonstrate that macromolecular fractions with electrophoretic mobility can also be detected within HCN polymers. The migration of polymers under the influence of an electric field depends not only on their sizes (one-dimensional electrophoresis) but also their different isoelectric points (two-dimensional electrophoresis, 2-DE). The same behaviour was observed for several macromolecular fractions detected in HCN polymers. Macromolecular fractions with apparent molecular weights as high as 250 kDa were detected by tricine-SDS gel electrophoresis. Cationic macromolecular fractions with apparent molecular weights as high as 140 kDa were also detected by 2-DE. The HCN polymers synthesized were fractionated by ultrafiltration. As a result, the molecular weight distributions of the macromolecular fractions detected in the HCN polymers directly depended on the synthetic conditions used to produce these polymers. The implications of these results for prebiotic chemistry will be discussed.
[Mh] Termos MeSH primário: Eletroforese/métodos
Cianeto de Hidrogênio/química
Substâncias Macromoleculares/isolamento & purificação
Polímeros/química
Ultrafiltração/métodos
[Mh] Termos MeSH secundário: Fracionamento Químico
Peso Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Macromolecular Substances); 0 (Polymers); 2WTB3V159F (Hydrogen Cyanide)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170228
[Lr] Data última revisão:
170228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160813
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600241


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[PMID]:27664840
[Au] Autor:Pauluhn J
[Ad] Endereço:Hannover Medical School, Hannover, Germany; 4th Military Medical University, Xi'an, China. Electronic address: juergen.pauluhn@iCLOUD.com.
[Ti] Título:Risk assessment in combustion toxicology: Should carbon dioxide be recognized as a modifier of toxicity or separate toxicological entity?
[So] Source:Toxicol Lett;262:142-152, 2016 Nov 16.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:To characterize the accumulated hazards associated with the inhalation of gases typical of combustion products, a time-integrated value known as the fractional effective dose (FED) is used. This FED is maintained by the International Organization for Standardization (ISO) and made publicly available as the Standard ISO 13571. The current FED calculation related to asphyxiant gases is based on non-human primate data to estimate the 50% probability of humans to be incapacitated or not being able to execute any escape paradigm from fires. The objective of this paper was to compare two to calculate FEDs of the most common mixture of asphyxiant fire gases CO, HCN, and CO . The first was based on the current ISO 13571 (draft) standard, the alternative second method applied the conceptual principles established for the derivation of Acute Emergency Response Planning Guideline values. The alternative approach applied one third of the non-lethal threshold concentration (LC ) as the most suitable and robust Point of Departure (POD) to estimate the threshold characterizing 'impairment of escape' in the absence of post-exposure mortality. The hyperventilation correction factor for CO of ISO 13571 was replaced by a separate term that accounts for the inherent acute toxicity of CO . This analysis supports the conclusion that the current ISO 13571 standard misjudges the impact of the acute toxicity elicited by concentrations of CO exceeding ≈6%. While underestimating the hazards attributable to CO , the hyperventilation adjustment factor suggested by this standard is biased to markedly overestimate the hazards assigned to CO and HCN in fire effluents.
[Mh] Termos MeSH primário: Asfixia/induzido quimicamente
Dióxido de Carbono/toxicidade
Fogo
Gases/toxicidade
[Mh] Termos MeSH secundário: Animais
Asfixia/patologia
Monóxido de Carbono/toxicidade
Carboxihemoglobina/metabolismo
Seres Humanos
Cianeto de Hidrogênio/toxicidade
Hiperventilação/fisiopatologia
Dose Letal Mediana
Ratos
Mecânica Respiratória/efeitos dos fármacos
Medição de Risco
Local de Trabalho/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gases); 142M471B3J (Carbon Dioxide); 2WTB3V159F (Hydrogen Cyanide); 7U1EE4V452 (Carbon Monoxide); 9061-29-4 (Carboxyhemoglobin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160925
[St] Status:MEDLINE


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[PMID]:27627883
[Au] Autor:Sudawan B; Chang CS; Chao HF; Ku MS; Yen YF
[Ad] Endereço:Ph.D. Program of Agricultural Science, National Chiayi University, Chiayi, 60004, Taiwan.
[Ti] Título:Hydrogen cyanamide breaks grapevine bud dormancy in the summer through transient activation of gene expression and accumulation of reactive oxygen and nitrogen species.
[So] Source:BMC Plant Biol;16(1):202, 2016 Sep 15.
[Is] ISSN:1471-2229
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hydrogen cyanamide (HC) and pruning (P) have frequently been used to break dormancy in grapevine floral buds. However, the exact underlying mechanism remains elusive. This study aimed to address the early mode of action of these treatments on accumulation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and expression of related genes in the dormancy breaking buds of grapevine in the summer. RESULTS: The budbreak rates induced by pruning (P), hydrogen cyanamide (HC), pruning plus hydrogen cyanamide (PHC) and water (control) after 8 days were 33, 53, 95, and 0 %, respectively. Clearly, HC was more effective in stimulating grapevine budbreak and P further enhanced its potency. In situ staining of longitudinal bud sections after 12 h of treatments detected high levels of ROS and nitric oxide (NO) accumulated in the buds treated with PHC, compared with HC or P alone. The amounts of ROS and NO accumulated were highly correlated with the rates of budbreak among these treatments, highlighting the importance of a rapid, transient accumulation of sublethal levels of ROS and RNS in dormancy breaking. Microarray analysis revealed specific alterations in gene expression in dormancy breaking buds induced by P, HC and PHC after 24 h of treatment. Relative to control, PHC altered the expression of the largest number of genes, while P affected the expression of the least number of genes. PHC also exerted a greater intensity in transcriptional activation of these genes. Gene ontology (GO) analysis suggests that alteration in expression of ROS related genes is the major factor responsible for budbreak. qRT-PCR analysis revealed the transient expression dynamics of 12 specific genes related to ROS generation and scavenge during the 48 h treatment with PHC. CONCLUSION: Our results suggest that rapid accumulation of ROS and NO at early stage is important for dormancy release in grapevine in the summer, and the identification of the commonly expressed specific genes among the treatments allowed the construction of the signal transduction pathway related to ROS/RNS metabolism during dormancy release. The rapid accumulation of a sublethal level of ROS/RNS subsequently induces cell wall loosening and expansion for bud sprouting.
[Mh] Termos MeSH primário: Regulação da Expressão Gênica de Plantas/efeitos dos fármacos
Cianeto de Hidrogênio/farmacologia
Dormência de Plantas/efeitos dos fármacos
Espécies Reativas de Nitrogênio/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Vitis/efeitos dos fármacos
Vitis/genética
[Mh] Termos MeSH secundário: Flores/efeitos dos fármacos
Flores/genética
Flores/crescimento & desenvolvimento
Flores/metabolismo
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
Caules de Planta/efeitos dos fármacos
Caules de Planta/genética
Caules de Planta/crescimento & desenvolvimento
Caules de Planta/metabolismo
Estações do Ano
Vitis/crescimento & desenvolvimento
Vitis/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Proteins); 0 (Reactive Nitrogen Species); 0 (Reactive Oxygen Species); 2WTB3V159F (Hydrogen Cyanide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160916
[St] Status:MEDLINE
[do] DOI:10.1186/s12870-016-0889-y


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[PMID]:27550574
[Au] Autor:Solans M; Scervino JM; Messuti MI; Vobis G; Wall LG
[Ad] Endereço:INIBIOMA, UNComahue, CONICET. CRUB, Quintral 1250, S. C. Bariloche, 8400, Argentina.
[Ti] Título:Potential biocontrol actinobacteria: Rhizospheric isolates from the Argentine Pampas lowlands legumes.
[So] Source:J Basic Microbiol;56(11):1289-1298, 2016 Nov.
[Is] ISSN:1521-4028
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Control of fungal plant diseases by using naturally occurring non-pathogenic microorganisms represents a promising approach to biocontrol agents. This study reports the isolation, characterization, and fungal antagonistic activity of actinobacteria from forage soils in the Flooding Pampa, Argentina. A total of 32 saprophytic strains of actinobacteria were obtained by different isolation methods from rhizospheric soil of Lotus tenuis growing in the Salado River Basin. Based on physiological traits, eight isolates were selected for their biocontrol-related activities such as production of lytic extracellular enzymes, siderophores, hydrogen cyanide (HCN), and antagonistic activity against Cercospora sojina, Macrophomia phaseolina, Phomopsis sp., Fusarium oxysporum, and Fusarium verticilloides. These actinobacteria strains were characterized morphologically, physiologically, and identified by using molecular techniques. The characterization of biocontrol-related activities in vitro showed positive results for exoprotease, phospholipase, fungal growth inhibition, and siderophore production. However, none of the strains was positive for the production of hydrogen cyanide (HCN). Streptomyces sp. MM140 presented the highest index for biocontrol, and appear to be promising pathogenic fungi biocontrol agents. These results show the potential capacity of actinobacteria isolated from forage soils in the Argentine Pampas lowlands as promising biocontrol agents, and their future agronomic applications.
[Mh] Termos MeSH primário: Actinobacteria/isolamento & purificação
Actinobacteria/fisiologia
Antibiose
Agentes de Controle Biológico/isolamento & purificação
Fabaceae/microbiologia
Rizosfera
Microbiologia do Solo
[Mh] Termos MeSH secundário: Actinobacteria/química
Actinobacteria/genética
Antifúngicos/farmacologia
Argentina
Ascomicetos
Produtos Biológicos/farmacologia
Fusarium/efeitos dos fármacos
Cianeto de Hidrogênio/metabolismo
Doenças das Plantas/microbiologia
Sideróforos/biossíntese
Streptomyces/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Biological Control Agents); 0 (Biological Products); 0 (Siderophores); 2WTB3V159F (Hydrogen Cyanide)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170207
[Lr] Data última revisão:
170207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160824
[St] Status:MEDLINE
[do] DOI:10.1002/jobm.201600323


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[PMID]:27394000
[Au] Autor:Jain R; Pandey A
[Ad] Endereço:Biotechnological Applications, G.B. Pant Institute of Himalayan Environment and Development, Kosi-Katarmal, Almora, 263 643, Uttarakhand, India.
[Ti] Título:A phenazine-1-carboxylic acid producing polyextremophilic Pseudomonas chlororaphis (MCC2693) strain, isolated from mountain ecosystem, possesses biocontrol and plant growth promotion abilities.
[So] Source:Microbiol Res;190:63-71, 2016 Sep.
[Is] ISSN:1618-0623
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The genus Pseudomonas is known to comprise a huge diversity of species with the ability to thrive in different habitats, including those considered as extreme environments. In the present study, a psychrotolerant, wide pH tolerant and halotolerant strain of Pseudomonas chlororaphis GBPI_507 (MCC2693), isolated from the wheat rhizosphere growing in a mountain location in Indian Himalayan Region (IHR), has been investigated for its antimicrobial potential with particular reference to phenazine production and plant growth promoting traits. GBPI_507 showed phenazine production at the temperatures ranged from 14 to 25°C. The benzene extracted compound identified as phenazine-1-carboxylic acid (PCA) through GC-MS exhibited antimicrobial properties against Gram positive bacteria and actinomycetes. The inhibition of phytopathogens in diffusible biocontrol assays was recorded in an order: Alternaria alternata>Phytophthora sp.>Fusarium solani>F. oxysporum. In volatile metabolite assays, all the pathogens, except Phytophthora sp. produced distorted colonies, characterized by restricted sporulation. The isolate also possessed other growth promoting and biocontrol traits including phosphate solubilization and production of siderophores, HCN, ammonia, and lytic enzymes (lipase and protease). Molecular studies confirmed production of PCA by the bacterium GBPI_507 through presence of phzCD and phzE genes in its genome. The polyextremophilic bacterial strain possesses various important characters to consider it as a potential agent for field applications, especially in mountain ecosystem, for sustainable and eco-friendly crop production.
[Mh] Termos MeSH primário: Desenvolvimento Vegetal/efeitos dos fármacos
Reguladores de Crescimento de Planta/metabolismo
Pseudomonas chlororaphis/metabolismo
[Mh] Termos MeSH secundário: Antibacterianos/metabolismo
Análise por Conglomerados
DNA Bacteriano/química
DNA Bacteriano/genética
DNA Ribossômico/química
DNA Ribossômico/genética
Enzimas/metabolismo
Cromatografia Gasosa-Espectrometria de Massas
Bactérias Gram-Positivas/efeitos dos fármacos
Bactérias Gram-Positivas/crescimento & desenvolvimento
Cianeto de Hidrogênio/metabolismo
Índia
Testes de Sensibilidade Microbiana
Fenazinas/metabolismo
Fosfatos/metabolismo
Filogenia
Pseudomonas chlororaphis/classificação
Pseudomonas chlororaphis/genética
Pseudomonas chlororaphis/isolamento & purificação
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
Sideróforos/metabolismo
Microbiologia do Solo
Temperatura Ambiente
Triticum/crescimento & desenvolvimento
Triticum/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (DNA, Bacterial); 0 (DNA, Ribosomal); 0 (Enzymes); 0 (Phenazines); 0 (Phosphates); 0 (Plant Growth Regulators); 0 (RNA, Ribosomal, 16S); 0 (Siderophores); 2538-68-3 (1-phenazinecarboxylic acid); 2WTB3V159F (Hydrogen Cyanide)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170404
[Lr] Data última revisão:
170404
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160710
[St] Status:MEDLINE


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[PMID]:27346845
[Au] Autor:Pauluhn J
[Ad] Endereço:Hannover Medical School, Hannover, Germany. Electronic address: juergen.pauluhn@iCLOUD.com.
[Ti] Título:Acute inhalation toxicity of carbon monoxide and hydrogen cyanide revisited: Comparison of models to disentangle the concentration × time conundrum of lethality and incapacitation.
[So] Source:Regul Toxicol Pharmacol;80:173-82, 2016 Oct.
[Is] ISSN:1096-0295
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Contemporary emergency response planning guidelines are stratified to consider the threshold for serious toxicity and/or impairment of escape, relative to the potentially lethal level above this threshold and the lower level at which individuals should not experience or develop effects more serious than mild irritation. While harmonized testing guidelines and risk assessment paradigms are available for the quantification of thresholds for lethality or establishing no adverse effect levels, the quantification of 'impairment of escape' appears to be a more elusive goal. Approaches were explored in context with CO and HCN in past experimental combustion toxicology studies to estimate the time available for escape. This point of departure (POD) was compared with the non-lethal threshold (LC01) and one third thereof from published recent acute inhalation studies in rats examining the Cxt-matrix of both CO and HCN. The findings from this analysis suggest that the rat delivers the most consistent data. However, it remains challenging yet to bridge the behavioral variables of human behavior typical of escape to any surrogate animal model. For the asphyxiant gases examined, the PODs characterizing 'impairment of escape' were difficult to distinguish from those indicative of impending death. No specific modeled carboxyhemoglobin (COHb) level could be linked to onset of incapacitation. In summary, the higher ventilation of rats (kg body weight adjusted) renders this species even more susceptible than heavy breathing humans. LCt01 × 1/3 values derived from the comprehensive Cxt matrix of rat inhalation studies are considered to be most suitable and robust to estimate the human equivalent threshold (POD) of 'impairment of escape'.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos dos fármacos
Monóxido de Carbono/toxicidade
Reação de Fuga/efeitos dos fármacos
Cianeto de Hidrogênio/toxicidade
Testes de Toxicidade Aguda/métodos
[Mh] Termos MeSH secundário: Animais
Bioensaio
Biomarcadores/sangue
Monóxido de Carbono/sangue
Carboxihemoglobina/metabolismo
Relação Dose-Resposta a Droga
Seres Humanos
Exposição por Inalação/efeitos adversos
Dose Letal Mediana
Modelos Animais
Modelos Biológicos
Ratos
Reprodutibilidade dos Testes
Medição de Risco
Especificidade da Espécie
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (Biomarkers); 2WTB3V159F (Hydrogen Cyanide); 7U1EE4V452 (Carbon Monoxide); 9061-29-4 (Carboxyhemoglobin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160628
[St] Status:MEDLINE



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