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[PMID]:29231020
[Au] Autor:Qiang HS; Chen H; Shen BH; Shen M; Xiang P
[Ad] Endereço:Pharmacy School of Wenzhou Medical University, Wenzhou 325035, China.
[Ti] Título:[Determination of Sulfide Ion in Blood from Hydrogen Sulfide Poisoning Cases].
[So] Source:Fa Yi Xue Za Zhi;33(2):148-153, 2017 Apr.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To establish a gas chromatography-mass spectrometry (GC-MS) method for the determination of sulfide ion in blood and apply it to the practical cases. METHODS: The 1, 3, 5-tribromobenzene was selected as an internal standard, and 0.2 mL blood sample was collected and analyzed using GC-MS after α-Bromo-2, 3, 4, 5, 6-pentafluorobenzyl bromide derivatization. RESULTS: The mass concentration of sulfide ion in blood had good linearity in the range of 0.2-40 µg/mL with a limit of detection (LOD) of 0.05 µg/mL. The mass concentration of sulfide ion was less than 0.05 µg/mL in blank blood from different sources such as healthy subjects and dead cases. In 3 sulfide poisoning cases, sulfide ion was detected in the blood samples of 6 victims, and the mass concentration range was 1.02-3.13 µg/mL. CONCLUSIONS: This study establishes a method for investigation of sulfide ion in blood which has been applied successfully to the cases of fatal sulfide poisonings.
[Mh] Termos MeSH primário: Cromatografia Gasosa-Espectrometria de Massas/métodos
Sulfeto de Hidrogênio/sangue
[Mh] Termos MeSH secundário: Fluorbenzenos
Seres Humanos
Limite de Detecção
Sulfetos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluorobenzenes); 0 (Sulfides); 1765-40-8 (pentafluorobenzyl bromide); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2017.02.008


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[PMID]:28454695
[Au] Autor:Hu TX; Guo X; Wang G; Gao L; He P; Xia Y; Gu H; Ni X
[Ad] Endereço:Department of Physiology, Second Military Medical University, Shanghai, China; No.117 Hospital of PLA, Hangzhou, China.
[Ti] Título:MiR133b is involved in endogenous hydrogen sulfide suppression of sFlt-1 production in human placenta.
[So] Source:Placenta;52:33-40, 2017 Apr.
[Is] ISSN:1532-3102
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Increased production of soluble fms-like tyrosine kinase-1 (sFlt-1) from placenta is one of the major contributors to the development of preeclampsia. Our previous study has shown that hydrogen sulfide (H S) inhibits sFlt-1 release in placenta. In the present study, we sought to investigate whether endogenous H S affects sFlt-1 production and elucidate which H S-producing enzyme is responsible for its effect in placenta. It was found that, besides cystathionine ß-synthase (CBS) and cystathionine γ-lyase (CSE), 3-mercaptopyruvatesulfurtransferase (3-MST) was identified in human placenta and mainly localized in syncytiotrophoblasts. There was no significant difference in expression level of 3-MST among preeclamptic and normal placentas. Treatment of cultured syncytiotrophoblasts with NaHS and l-cysteine suppressed sFlt-1 mRNA expression and caused a decrease in sFlt-1 protein content in culture media of the cells. Transfection of syncytiotrophoblasts with CBS siRNA and CSE siRNA reversed the above effects of l-cysteine. Furthermore, NaHS and l-cysteine treatment decreased the half-life of sFlt-1 mRNA and increased the expression of miR-133b targeting sFlt-1. MiR-133b expression was downregulated in preeclamptic placentas and correlated with the level of CBS and CSE. These results indicate that H S is an important regulatory factor in sFlt-1 production in placenta. Reduced H S generation in placenta contributes to development of preeclampsia by enhancing sFlt-1 production.
[Mh] Termos MeSH primário: Sulfeto de Hidrogênio/metabolismo
MicroRNAs/metabolismo
Placenta/metabolismo
Receptor 1 de Fatores de Crescimento do Endotélio Vascular/metabolismo
[Mh] Termos MeSH secundário: Células Cultivadas
Cistationina beta-Sintase/metabolismo
Cistationina gama-Liase/metabolismo
Cisteína/farmacologia
Regulação para Baixo
Feminino
Seres Humanos
Sulfeto de Hidrogênio/farmacologia
Gravidez
Sulfurtransferases/metabolismo
Trofoblastos/efeitos dos fármacos
Trofoblastos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MIRN133 microRNA, human); 0 (MicroRNAs); EC 2.7.10.1 (FLT1 protein, human); EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-1); EC 2.8.1.- (Sulfurtransferases); EC 2.8.1.2 (3-mercaptopyruvate sulphurtransferase); EC 4.2.1.22 (Cystathionine beta-Synthase); EC 4.4.1.1 (Cystathionine gamma-Lyase); K848JZ4886 (Cysteine); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:29478642
[Au] Autor:Ning P; Liu S; Wang C; Li K; Sun X; Tang L; Liu G
[Ad] Endereço:Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.
[Ti] Título:Adsorption-oxidation of hydrogen sulfide on Fe/walnut-shell activated carbon surface modified by NH -plasma.
[So] Source:J Environ Sci (China);64:216-226, 2018 Feb.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Walnut-shell activated carbon (WSAC) supported ferric oxide was modified by non-thermal plasma (NTP), and the removal efficiency for hydrogen sulfide over Fe/WSAC modified by dielectric barrier discharge (DBD) was significantly promoted. The sample modified for 10min and 6.8kV output (30V input voltage) maintained 100% H S conversion over a long reaction time of 390min. The surface properties of adsorbents modified by NTP under different conditions were evaluated by the methods of X-ray photoelectron spectroscopy (XPS), Brunauer-Emmett-Teller (BET) analysis and in-situ Fourier transform infrared spectroscopy (FTIR), to help understand the effect of the NTP treatment. NTP treatment enhanced the adsorption capacity of Fe/WSAC, which could due to the formation of micro-pores with sizes of 0.4, 0.5 and 0.75nm. XPS revealed that chemisorbed oxygen changed into lattice oxygen after NTP treatment, and lattice oxygen is beneficial for H S oxidation. From the in-situ FTIR result, transformation of the reaction path on Fe/WSAC was observed after NTP modification. The research results indicate that NTP is an effective method to improve the surface properties of the Fe/WSAC catalyst for H S adsorption-oxidation.
[Mh] Termos MeSH primário: Amônia/química
Sulfeto de Hidrogênio/química
Ferro/química
Modelos Químicos
[Mh] Termos MeSH secundário: Adsorção
Carvão Vegetal/química
Juglans
Oxirredução
Gases em Plasma
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plasma Gases); 16291-96-6 (Charcoal); 7664-41-7 (Ammonia); E1UOL152H7 (Iron); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE


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[PMID]:29248819
[Au] Autor:Searcy DG
[Ad] Endereço:Biology Department, University of Massachusetts, Amherst, MA 01003, USA. Electronic address: dsearcy@bio.umass.edu.
[Ti] Título:Elemental sulfur reduction to H S by Tetrahymena thermophila.
[So] Source:Eur J Protistol;62:56-68, 2018 Feb.
[Is] ISSN:1618-0429
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Eukaryotic nucleocytoplasm is believed to be descended from ancient Archaea that respired on elemental sulfur. If so, a vestige of sulfur reduction might persist in modern eukaryotic cells. That was tested in Tetrahymena thermophila, chosen as a model organism. When oxygenated, the cells consumed H S rapidly, but when made anoxic they produced H S mostly by amino acid catabolism. That could be inhibited by adding aminooxyacetic acid, and then H S production from elemental sulfur became more evident. Anoxic cell lysates produced H S when provided with sulfur and NADH, but not with either substrate alone. When lysates were fractionated by centrifugation, NADH-dependent H S production was 83% in the soluble fraction. When intact cells that had just previously oxidized H S were shifted to anoxia, the cells produced H S evidently by re-using the oxidized sulfur. After aerobic H S oxidation was stopped, the oxidation product remained available for H S production for about 10 min. The observed H S production is consistent with an evolutionary relationship of nucleocytoplasm to sulfur-reducing Archaea. Mitochondria often are the cellular site of H S oxidation, suggesting that eukaryotic cells might have evolved from an ancient symbiosis that was based upon sulfur exchange.
[Mh] Termos MeSH primário: Enxofre/metabolismo
Tetrahymena thermophila/metabolismo
[Mh] Termos MeSH secundário: Sulfeto de Hidrogênio/química
Mitocôndrias/metabolismo
Oxirredução
Enxofre/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
70FD1KFU70 (Sulfur); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171218
[St] Status:MEDLINE


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[PMID]:29292088
[Au] Autor:Yang LL; Zhao Y; Luo SM; Ma JY; Ge ZJ; Shen W; Yin S
[Ad] Endereço:College of Life Sciences, Institute of Reproductive Sciences, Qingdao Agricultural University, Qingdao, 266109, China.
[Ti] Título:Toxic effects and possible mechanisms of hydrogen sulfide and/or ammonia on porcine oocyte maturation in vitro.
[So] Source:Toxicol Lett;285:20-26, 2018 Mar 15.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Previous studies suggest that hydrogen sulfide (H S) and ammonia (NH ) are two major air pollutants which can cause damage to porcine health. However, the mechanisms underlying toxic effects of these compounds on porcine oocyte maturation are not clear. To clarify the mechanism, we evaluated the oocyte quality by detecting some events during oocytes maturation. In our study, porcine oocytes were cultured with different concentrations of Na S and/or NH Cl in vitro and the rate of the first polar body extrusion decreased significantly. Also, actin filament was seriously disrupted to damage the cytoskeleton which resulted in reduced rate of oocyte maturation. We explored the reactive oxygen species (ROS) generation and found that the ROS level was increased significantly after Na S treatment but not after NH Cl treatment. Moreover, early stage apoptosis rate was significantly increased and autophagy protein LC3 B expression level was higher in oocytes treated with Na S and/or NH Cl, which might be caused by ROS elevation. Additionally, exposure to Na S and/or NH Cl also caused ROS generation and early apoptosis in cumulus cells, which might further affect oocyte maturation in vitro. In summary, our data suggested that exposure to H S and/or NH decreased porcine oocyte maturation in vitro, which might be caused by actin disruption, ROS generation, early apoptosis and autophagy.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/toxicidade
Amônia/toxicidade
Sulfeto de Hidrogênio/toxicidade
Oócitos/efeitos dos fármacos
Oogênese/efeitos dos fármacos
[Mh] Termos MeSH secundário: Actinas/metabolismo
Amônia/administração & dosagem
Animais
Apoptose/efeitos dos fármacos
Autofagia/efeitos dos fármacos
Células Cultivadas
Feminino
Sulfeto de Hidrogênio/administração & dosagem
Oócitos/metabolismo
Oócitos/patologia
Corpos Polares/efeitos dos fármacos
Corpos Polares/metabolismo
Corpos Polares/patologia
Espécies Reativas de Oxigênio/metabolismo
Sus scrofa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Actins); 0 (Air Pollutants); 0 (Reactive Oxygen Species); 7664-41-7 (Ammonia); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE


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[PMID]:29331374
[Au] Autor:Nagahara N; Koike S; Nirasawa T; Kimura H; Ogasawara Y
[Ad] Endereço:Isotope Research Center, Nippon Medical School, Japan. Electronic address: noriyuki@nms.ac.jp.
[Ti] Título:Alternative pathway of H S and polysulfides production from sulfurated catalytic-cysteine of reaction intermediates of 3-mercaptopyruvate sulfurtransferase.
[So] Source:Biochem Biophys Res Commun;496(2):648-653, 2018 02 05.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It has been known that hydrogen sulfide and/or polysulfides are produced from a (poly)sulfurated sulfur-acceptor substrate of 3-mercaptopyruvate sulfurtransferase (MST) via thioredoxin (Trx) reduction in vitro. In this study, we used thiosulfate as the donor substrate and the catalytic reaction was terminated on the formation of a persulfide or polysulfides. We can present alternative pathway of production of hydrogen sulfide and/or polysulfides from (poly)sulfurated catalytic-site cysteine of reaction intermediates of MST via Trx reduction. Matrix-assisted laser desorption ionization tandem time-of-flight mass spectrometric analysis revealed that after prolonged incubation of MST with thiosulfate, a trisulfide adduct becomes predominant at the sulfurated catalytic-site cysteine. When these adducts were reduced by Trx with reducing system (MST:Escherichia coli Trx:E. coli Trx reductase:NADPH = 1:5:0.02:12.5 molar ratio), liquid chromatography with tandem mass spectrometric analysis for monobromobimane-derivatized H S revealed that H S first appeared, and then H S and H S did later. The results were confirmed by high-performance liquid chromatography-fluorescence analysis.
[Mh] Termos MeSH primário: Cisteína/metabolismo
Sulfeto de Hidrogênio/metabolismo
Sulfetos/metabolismo
Sulfurtransferases/metabolismo
[Mh] Termos MeSH secundário: Animais
Escherichia coli/metabolismo
Proteínas de Escherichia coli/metabolismo
Oxirredução
Ratos
Proteínas Recombinantes/metabolismo
Tiorredoxina Dissulfeto Redutase/metabolismo
Tiorredoxinas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Escherichia coli Proteins); 0 (Recombinant Proteins); 0 (Sulfides); 52500-60-4 (Thioredoxins); 9080-49-3 (polysulfide); EC 1.8.1.9 (Thioredoxin-Disulfide Reductase); EC 2.8.1.- (Sulfurtransferases); EC 2.8.1.2 (3-mercaptopyruvate sulphurtransferase); K848JZ4886 (Cysteine); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180115
[St] Status:MEDLINE


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[PMID]:29249255
[Au] Autor:Sun Q; Chen Z; He P; Li Y; Ding X; Huang Y; Gu H; Ni X
[Ad] Endereço:Department of Physiology, Second Military Medical University, Shanghai, China; Department of Gynecology and Obstetrics, Changhai Hospital, Shanghai, China.
[Ti] Título:Reduced Expression of Hydrogen Sulfide-Generating Enzymes Down-Regulates 15-Hydroxyprostaglandin Dehydrogenase in Chorion during Term and Preterm Labor.
[So] Source:Am J Pathol;188(1):63-71, 2018 01.
[Is] ISSN:1525-2191
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chorionic NAD-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) plays a pivotal role in controlling the amount of prostaglandins in the uterus and has been implicated in the process of labor. Prior studies identified hydrogen sulfide-generating enzymes cystathionine-ß-synthetase (CBS) and cystathionine-γ-lyase (CSE) in fetal membranes. We investigated whether hydrogen sulfide is involved in the regulation of PGDH expression in the chorion during labor. The chorionic tissues were obtained from pregnant women at preterm in labor and at term in labor or not in labor at term. Levels of CSE and CBS and hydrogen sulfide production rate were down-regulated in term in labor and preterm in labor groups compared with not in labor at term group. The CBS level correlated to PGDH expression in the chorion. Hydrogen sulfide donor NaHS and precursor l-cysteine dose-dependently stimulated PGDH expression and activity in cultured chorionic trophoblasts. The effect of l-cysteine was blocked by CBS inhibitor and CBS siRNA but not by CSE inhibitor and CSE siRNA. Hydrogen sulfide treatment suppressed miR-26b and miR-199a expression in chorionic trophoblasts. miR-26b and miR-199a mimics blocked hydrogen sulfide upregulation of PGDH expression. Our results indicate that hydrogen sulfide plays pivotal roles in maintenance of PGDH expression in the chorion during human pregnancy. Reduced expression of hydrogen sulfide-generating enzymes contributes to an increased amount of prostaglandins in the uterus during labor.
[Mh] Termos MeSH primário: Córion/enzimologia
Cistationina beta-Sintase/metabolismo
Cistationina gama-Liase/metabolismo
Hidroxiprostaglandina Desidrogenases/metabolismo
Trabalho de Parto Prematuro/metabolismo
Nascimento a Termo/metabolismo
[Mh] Termos MeSH secundário: Cistationina gama-Liase/genética
Regulação para Baixo
Feminino
Seres Humanos
Sulfeto de Hidrogênio/metabolismo
Hidroxiprostaglandina Desidrogenases/genética
Trabalho de Parto Prematuro/genética
Gravidez
Nascimento a Termo/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
EC 1.1.1.- (Hydroxyprostaglandin Dehydrogenases); EC 1.1.1.141 (15-hydroxyprostaglandin dehydrogenase); EC 4.2.1.22 (Cystathionine beta-Synthase); EC 4.4.1.1 (Cystathionine gamma-Lyase); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


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[PMID]:29283238
[Au] Autor:Gusakova SV; Smagliy LV; Birulina YG; Kovalev IV; Nosarev V; Petrova IV; Reutov VP
[Ti] Título:Molecular Mechanisms of Action of Gas Transmitters NO, CO and H2S in Smooth Muscle Cells and Effect of NO-generating Compounds (Nitrates and Nitrites) on Average Life Expectancy.
[So] Source:Usp Fiziol Nauk;48(1):24-52, 2017 Jan-Mar.
[Is] ISSN:0301-1798
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Gaseous signaling molecules (gas transmitters) take an especial position among the numerous signaling molecules involved in the regulation of both intracellular processes that occur in different types of cells and cell-cell interactions. At present time, gas transmitters include three molecules whose enzymatic systems of synthesis and degradation, physiological action and intracellular effectors, the change of which under the action of gas transmitters may result in physiological and/or pathophysiological effects are well- determined. These molecules include nitrogen oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S). They are involved in the regulation of functions of various organs and systems of the human body, including the circulatory system. Interaction of NO, CO and H2S with various enzymatic and structural components of endothelial and, especially, smooth muscle cells has a significant impact on vascular tone and blood pressure. Furthermore, the crossing of NO-, CO- and H2S-mediated signaling pathways at common effectors and interaction with each other can determine the end, resulting functional response of the cell. The knowledge of the molecular targets of gas transmitters' action, the structure of the binding centers for gas transmitters and their interaction with each other may be essential in the development of methods of regulation of these signaling systems by targeted, directed action. This review summarizes the molecular mechanisms of the NO, CO and H2S interaction with the main targets, which carry out their regulatory effect on vascular smooth muscle cells. Also we describe here different ways of cross-regulation of NO-, CO- and H2S-dependent signaling pathways. We analyzed NO-synthase and nitrite reductase systems of nitric oxide cycle and discuss the nitrate-nitrite background of the existence of modern man, which can substantially modify the signaling system, the metabolism of virtually all cell ultrastructure of neurons, neuron-neuron and neuron-glial interactions and exerts its influence on socially significant diseases that can affect the quality and the average life expectancy.
[Mh] Termos MeSH primário: Monóxido de Carbono/metabolismo
Gasotransmissores/metabolismo
Sulfeto de Hidrogênio/metabolismo
Expectativa de Vida/tendências
Miócitos de Músculo Liso/efeitos dos fármacos
Doadores de Óxido Nítrico/toxicidade
Óxido Nítrico/metabolismo
[Mh] Termos MeSH secundário: Animais
Canais de Cálcio/genética
Canais de Cálcio/metabolismo
Comunicação Celular
Regulação da Expressão Gênica
Seres Humanos
Miócitos de Músculo Liso/citologia
Miócitos de Músculo Liso/metabolismo
Neuroglia/citologia
Neuroglia/efeitos dos fármacos
Neuroglia/metabolismo
Neurônios/citologia
Neurônios/efeitos dos fármacos
Neurônios/metabolismo
Óxido Nítrico Sintase Tipo III/genética
Óxido Nítrico Sintase Tipo III/metabolismo
Nitrito Redutases/genética
Nitrito Redutases/metabolismo
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Calcium Channels); 0 (Gasotransmitters); 0 (Nitric Oxide Donors); 31C4KY9ESH (Nitric Oxide); 7U1EE4V452 (Carbon Monoxide); EC 1.14.13.39 (NOS3 protein, human); EC 1.14.13.39 (Nitric Oxide Synthase Type III); EC 1.7.- (Nitrite Reductases); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE


  9 / 5464 MEDLINE  
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[PMID]:29283229
[Au] Autor:Sukmansky OI; Reutov VP
[Ti] Título:Gasotransmitters: Physiological Role and Involvement in the Pathogenesis of the Diseases.
[So] Source:Usp Fiziol Nauk;47(3):30-58, 2016 Jul-Sep.
[Is] ISSN:0301-1798
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:In recent decades, it has been found the existence of a new class of biologically active substances - gaseous mediators (gasotransmitters), performing in the cells the signaling function and with high specificity involved in the intercellular and intracellular communication. This review characterizes the main gasotransmitters: nitric oxide, carbon monoxide, hydrogen sulfide, sulfur dioxide and polysulfides. Their physiological role and involvement in the pathogenesis of diseases is described. Basic information about main gasotransmitters is generalized in the original table. Nitrate-Nitrite background, which is a chemical background of the existence of modern man, affects the intra- and intercellular signaling system, alters the ultrastructure of neurons, neuron-neuron and neuron-glia interaction, eliminates the effects of endogenous gasotransmitters and affects the average life expectancy. In accordance with the principle of cyclicity is proposed and substantiated the hypothesis of the existence of "hydrogen sulfide cycle", combining three sulfur-containing gasotransmitters. It is suggested that the cyclic organization of gasotransmitters in the cells and the whole body can be due to the existence of a global principle of cyclicity, which can spread its influence on almost all the structural and functional levels in the animate and inanimate nature.
[Mh] Termos MeSH primário: Monóxido de Carbono/metabolismo
Gasotransmissores/fisiologia
Sulfeto de Hidrogênio/metabolismo
Expectativa de Vida/tendências
Óxido Nítrico/fisiologia
Sulfetos/metabolismo
Dióxido de Enxofre/metabolismo
[Mh] Termos MeSH secundário: Doenças Cardiovasculares/metabolismo
Doenças Cardiovasculares/patologia
Comunicação Celular
Seres Humanos
Neoplasias/metabolismo
Neoplasias/patologia
Neuroglia/citologia
Neuroglia/fisiologia
Neurônios/citologia
Neurônios/fisiologia
Periodicidade
Transdução de Sinais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Gasotransmitters); 0 (Sulfides); 0UZA3422Q4 (Sulfur Dioxide); 31C4KY9ESH (Nitric Oxide); 7U1EE4V452 (Carbon Monoxide); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE


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[PMID]:28740857
[Au] Autor:Eusebio L; Capelli L; Sironi S
[Ad] Endereço:Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy.
[Ti] Título:H S Loss through Nalophan™ Bags: Contributions of Adsorption and Diffusion.
[So] Source:ScientificWorldJournal;2017:9690704, 2017.
[Is] ISSN:1537-744X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hydrogen-sulfide (H S) is a molecule of small dimensions typically present in the odor emissions from different plants. The European Standard EN 13725:2003 set a maximum storage time allowed of 30 hours, during which the sampling bag has to maintain the mixture of odorants with minimal changes. This study investigates the H S losses through Nalophan bags and it shows that nonnegligible losses of H S can be observed. The percent H S loss after 30 hrs with respect to the initial concentration is equal to 33% ± 3% at a relative humidity of 20% and equal to 22% ± 1% at a relative humidity of 60%. The average quantity of adsorbed H S at 30 h is equal to 2.17 10 g /g at a storage humidity of 20% and equal to 1.79 10 g /g at a storage humidity of 60%. The diffusion coefficients of H S through Nalophan, for these two humidity conditions tested, are comparable (i.e., 7.5 10 m /sec at 20% humidity and 6.6 10 m /sec at 60% humidity).
[Mh] Termos MeSH primário: Umidade
Sulfeto de Hidrogênio/análise
Polietilenotereftalatos
[Mh] Termos MeSH secundário: Adsorção
Difusão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Polyethylene Terephthalates); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1155/2017/9690704



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