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[PMID]:29194020
[Au] Autor:Zhang J; Yuan J; Zhang WX; Tu F; Jiang Y; Sun CZ
[Ad] Endereço:a Department of Life Science and Food Engineering/Key Laboratory of Fermentation Resource and Application in Sichuan/Department of Library , Yibin University , Yibin , Sichuan , China.
[Ti] Título:Anaerobic detoxification fermentation by Rhodospirillum rubrum for rice straw as feed with moderate pretreatment.
[So] Source:Prep Biochem Biotechnol;48(1):75-83, 2018 Jan 02.
[Is] ISSN:1532-2297
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel and effective process was put forward for converting rice straw into feed by combining diluted acid hydrolysis and ammonization with Rhodospirillum rubrum fermentation. After pretreatment with dilute sulfuric or phosphoric acid (1%, w/w) at 100°C, materials were subjected to fermentation under several gases (N , CO , and air) and different light intensities in a 2-L fermentor. The key indexes of feed for fermented materials were estimated and several toxic substances were investigated during the fermentation. Following sulfuric acid treatment, the true protein of rice straw increased from 29 to 143 g kg and the crude fiber decreased from 359 to 136 g kg after fermentation at 0.3 L min L of N flow and a light intensity of 3400 lux; and following phosphoric acid treatment, the true protein increased by 286% and the crude fiber decreased by 52% after fermentation at 0.4 L min L of N flow and a light intensity of 3000 lux. Other key contents were also improved for use as feed, and some toxic substances (i.e., furfural, hydroxymethylfurfural, acetic acid, phenol, cresol) produced by the pretreatments could be removed at low levels during the fermentations.
[Mh] Termos MeSH primário: Ração Animal/análise
Oryza/metabolismo
Rhodospirillum rubrum/metabolismo
[Mh] Termos MeSH secundário: Ração Animal/toxicidade
Fermentação
Hidrólise
Microbiologia Industrial
Luz
Ácidos Fosfóricos/metabolismo
Ácidos Sulfúricos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphoric Acids); 0 (Sulfuric Acids); E4GA8884NN (phosphoric acid); O40UQP6WCF (sulfuric acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1080/10826068.2017.1405023


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[PMID]:28461446
[Au] Autor:Pequegnat B; Laird RM; Ewing CP; Hill CL; Omari E; Poly F; Monteiro MA; Guerry P
[Ad] Endereço:Department of Chemistry, University of Guelph, Guelph, Ontario, Canada.
[Ti] Título:Phase-Variable Changes in the Position of -Methyl Phosphoramidate Modifications on the Polysaccharide Capsule of Campylobacter jejuni Modulate Serum Resistance.
[So] Source:J Bacteriol;199(14), 2017 07 15.
[Is] ISSN:1098-5530
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:polysaccharide capsules (CPS) are characterized by the presence of nonstoichiometric -methyl phosphoramidate (MeOPN) modifications. The lack of stoichiometry is due to phase variation at homopolymeric tracts within the MeOPN transferase genes. strain 81-176 contains two MeOPN transferase genes and has been shown previously to contain MeOPN modifications at the 2 and 6 positions of the galactose (Gal) moiety in the CPS. We demonstrate here that one of the two MeOPN transferases, encoded by CJJ81176_1435, is bifunctional and is responsible for the addition of MeOPN to both the 2 and the 6 positions of Gal. A new MeOPN at the 4 position of Gal was observed in a mutant lacking the CJJ81176_1435 transferase and this was encoded by the CJJ81176_1420 transferase. During routine growth of 81-176, the CJJ81176_1420 transferase was predominantly in an off configuration, while the CJJ81176_1435 transferase was primarily on. However, exposure to normal human serum selected for cells expressing the CJJ81176_1420 transferase. MeOPN modifications appear to block binding of naturally occurring antibodies to the 81-176 CPS. The absence of MeOPN-4-Gal resulted in enhanced sensitivity to serum killing, whereas the loss of MeOPN-2-Gal and MeOPN-6-Gal resulted in enhanced resistance to serum killing, perhaps by allowing more MeOPN to be put onto the 4 position of Gal. undergoes phase variation in genes encoding surface antigens, leading to the concept that a strain of this organism consists of multiple genotypes that are selected for fitness in various environments. Methyl phosphoramidate modifications on the capsule of block access of preexisting antibodies in normal human sera to the polysaccharide chain, thus preventing activation of the classical arm of the complement cascade. We show that the capsule of strain 81-176 contains more sites of MeOPN modifications than previously recognized and that one site, on the 4 position of galactose, is more critical to complement resistance than the others. Exposure to normal human serum selects for variants in the population expressing this MeOPN modification.
[Mh] Termos MeSH primário: Amidas
Cápsulas Bacterianas/fisiologia
Campylobacter jejuni/metabolismo
Soros Imunes/imunologia
Ácidos Fosfóricos
Polissacarídeos Bacterianos/metabolismo
[Mh] Termos MeSH secundário: Animais
Anticorpos Antibacterianos
Clonagem Molecular
Regulação Bacteriana da Expressão Gênica/fisiologia
Epitopos Imunodominantes
Mutação
Polissacarídeos Bacterianos/química
Polissacarídeos Bacterianos/imunologia
Coelhos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amides); 0 (Antibodies, Bacterial); 0 (Immune Sera); 0 (Immunodominant Epitopes); 0 (Phosphoric Acids); 0 (Polysaccharides, Bacterial); 9Q189608GB (phosphoramidic acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:29337564
[Au] Autor:Bruening EM; Schauss J; Siebert T; Fingerhut BP; Elsaesser T
[Ad] Endereço:Max-Born-Institut für Nichtlineare Optik und Kurzzeitspektroskopie , Max-Born-Str. 2a, D-12489 Berlin, Germany.
[Ti] Título:Vibrational Dynamics and Couplings of the Hydrated RNA Backbone: A Two-Dimensional Infrared Study.
[So] Source:J Phys Chem Lett;9(3):583-587, 2018 Feb 01.
[Is] ISSN:1948-7185
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The equilibrium structure of the RNA sugar-phosphate backbone and its hydration shell is distinctly different from hydrated DNA. Applying femtosecond two-dimensional infrared (2D-IR) spectroscopy in a range from 950 to 1300 cm , we elucidate the character, dynamics, and couplings of backbone modes of a double-stranded RNA A-helix geometry in its aqueous environment. The 2D-IR spectra display a greater number of backbone modes than for DNA, with distinctly different lineshapes of diagonal peaks. Phosphate-ribose interactions and local hydration structures are reflected in the complex coupling pattern of RNA modes. Interactions with the fluctuating water shell give rise to spectral diffusion on a 300 fs time scale, leading to a quasi-homogeneous line shape of the symmetric (PO ) stretching mode of the strongly hydrated phosphate groups. The RNA results are benchmarked by 2D-IR spectra of DNA oligomers in water and analyzed by molecular dynamics and quantum mechanical molecular mechanics simulations.
[Mh] Termos MeSH primário: Simulação de Dinâmica Molecular
RNA/química
Vibração
[Mh] Termos MeSH secundário: DNA/química
Fosfatos/química
Ácidos Fosfóricos
Ribose/metabolismo
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphates); 0 (Phosphoric Acids); 059QF0KO0R (Water); 63231-63-0 (RNA); 681HV46001 (Ribose); 9007-49-2 (DNA); E4GA8884NN (phosphoric acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jpclett.7b03314


  4 / 5728 MEDLINE  
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[PMID]:28450641
[Au] Autor:DiRocco DA; Ji Y; Sherer EC; Klapars A; Reibarkh M; Dropinski J; Mathew R; Maligres P; Hyde AM; Limanto J; Brunskill A; Ruck RT; Campeau LC; Davies IW
[Ad] Endereço:Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA. daniel.dirocco@merck.com.
[Ti] Título:A multifunctional catalyst that stereoselectively assembles prodrugs.
[So] Source:Science;356(6336):426-430, 2017 Apr 28.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The catalytic stereoselective synthesis of compounds with chiral phosphorus centers remains an unsolved problem. State-of-the-art methods rely on resolution or stoichiometric chiral auxiliaries. Phosphoramidate prodrugs are a critical component of pronucleotide (ProTide) therapies used in the treatment of viral disease and cancer. Here we describe the development of a catalytic stereoselective method for the installation of phosphorus-stereogenic phosphoramidates to nucleosides through a dynamic stereoselective process. Detailed mechanistic studies and computational modeling led to the rational design of a multifunctional catalyst that enables stereoselectivity as high as 99:1.
[Mh] Termos MeSH primário: Amidas/síntese química
Antineoplásicos/síntese química
Antivirais/síntese química
Nucleosídeos/síntese química
Ácidos Fosfóricos/síntese química
Pró-Fármacos/síntese química
[Mh] Termos MeSH secundário: Catálise
Simulação por Computador
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amides); 0 (Antineoplastic Agents); 0 (Antiviral Agents); 0 (Nucleosides); 0 (Phosphoric Acids); 0 (Prodrugs); 9Q189608GB (phosphoramidic acid)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1126/science.aam7936


  5 / 5728 MEDLINE  
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[PMID]:28873541
[Au] Autor:Yuan D; Jacquier JC; O'Riordan ED
[Ad] Endereço:Food for Health Ireland, Institute of Food and Health, University College Dublin, Belfield, Dublin 4, Ireland.
[Ti] Título:Entrapment of proteins and peptides in chitosan-polyphosphoric acid hydrogel beads: A new approach to achieve both high entrapment efficiency and controlled in vitro release.
[So] Source:Food Chem;239:1200-1209, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bovine serum albumin (BSA), whey protein isolate (WPI), insulin and a casein hydrolysate were entrapped in chitosan-polyphosphoric acid (PPA) beads. The in vitro release of protein from the beads in simulated gastric fluid (SGF, pH 3) and simulated intestinal fluid (SIF, pH 7) was evaluated. High entrapment efficiencies were achieved for intact proteins (>95% in all cases) but entrapment was lower for the casein hydrolysate (circa 50%), possibly indicating a physical or steric entrapment of the proteins in these chitosan-PPA beads. Inhibited release of BSA, in both SGF and SIF, was achieved with low PPA concentration. Insulin and WPI were effectively retained in SGF and gradually released in SIF. Peptides from casein hydrolysate were partially (circa 35%) but quickly released in SGF with no further release in SIF. Overall, these results indicate that chitosan-PPA beads show potential for lower gastrointestinal delivery of bioactive protein material.
[Mh] Termos MeSH primário: Peptídeos/análise
Proteínas/análise
[Mh] Termos MeSH secundário: Alginatos
Quitosana
Preparações de Ação Retardada
Hidrogel de Polietilenoglicol-Dimetacrilato
Concentração de Íons de Hidrogênio
Ácidos Fosfóricos
Polímeros
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alginates); 0 (Delayed-Action Preparations); 0 (Peptides); 0 (Phosphoric Acids); 0 (Polymers); 0 (Proteins); 25852-47-5 (Hydrogel, Polyethylene Glycol Dimethacrylate); 8017-16-1 (polyphosphoric acid); 9012-76-4 (Chitosan)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  6 / 5728 MEDLINE  
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[PMID]:27777071
[Au] Autor:Kong K; Hiraishi N; Nassar M; Otsuki M; Yiu CKY; Tagami J
[Ad] Endereço:Cariology and Operative Dentistry, Department of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan; General Dentistry, Roomchang Dental and Aesthetic Hospital, Phnom Penh, Cambodia.
[Ti] Título:Effect of phytic acid etchant on resin-dentin bonding: Monomer penetration and stability of dentin collagen.
[So] Source:J Prosthodont Res;61(3):251-258, 2017 Jul.
[Is] ISSN:2212-4632
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Phytic acid (IP6) works well as an etchant in dentin bonding to remove the smear layer due to its acidity and chelating effect. This study compared the etching effect of IP6 with phosphoric acid (PA) and ethylenediaminetetraacetic acid (EDTA) on resin-dentin bond strength, micromorphology of the etched dentin surface and nanoleakage formation along resin-dentin interfaces and compared the protecting effect against collagen degradation. METHODS: Dentin disks and flat dentin surfaces were obtained from extracted human teeth. Specimens were etched with 35% PA (15s), 0.5M EDTA (30s) or 1% IP6 (30s). The surfaces and longitudinal sections of the etched dentin disks were observed using field emission scanning electron microscope (FE-SEM). An etch-and-rinse adhesive was used to create composite build up-specimens for microtensile bond strength (µTBS) testing and nanoleakage observation. To evaluate the effect on collagen degradation, demineralized bovine root dentin blocks were challenged with bacterial collagenase and then observed under light microscope. RESULTS: PA- and EDTA- treated groups showed significantly lower µTBS when compared to IP6-treated group. PA showed distinct nanoleakage and severe collagen degradation. Only slight nanoleakage was detected in IP6 group. IP6 showed better effect than EDTA in preventing collagen degradation induced by bacterial collagenase. CONCLUSIONS: IP6 effectively removed the smear layer and etched dentin, providing high bond strength values and causing minimal nanoleakage and slight collagen degradation.
[Mh] Termos MeSH primário: Ataque Ácido Dentário
Colágeno
Colagem Dentária
Corrosão Dentária
Dentina
Ácido Fítico
Resinas Sintéticas
[Mh] Termos MeSH secundário: Ácido Edético
Seres Humanos
Ácidos Fosfóricos
Proteólise
Resistência à Tração
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphoric Acids); 0 (Resins, Synthetic); 7IGF0S7R8I (Phytic Acid); 9007-34-5 (Collagen); 9G34HU7RV0 (Edetic Acid); E4GA8884NN (phosphoric acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  7 / 5728 MEDLINE  
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[PMID]:28872993
[Au] Autor:Sönmez H; Saat S
[Ti] Título:A Clinical Evaluation of Deproteinization and Different Cavity Designs on Resin Restoration Performance in MIH-Affected Molars: Two-Year Results.
[So] Source:J Clin Pediatr Dent;41(5):336-342, 2017.
[Is] ISSN:1053-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of this study was to evaluate the clinical effects of deproteinization of the hypomineralized enamel and different cavity designs on the performance of the composite resin restorations(CRRs) placed into the cavities of MIH (molar incisor hypomineralization)-affected molars. STUDY DESIGN: 95 MIH-affected permanent first molars (PFMs) and 31 caries but not MIH-affected PFMs (126 teeth in total) were included in the study. The MIH-affected molars were divided into three groups. In Group I, all hypomineralized tissue was removed until healthy enamel was reached. In Group II, carious and cheesy hypomineralized tissue was removed until a reasonable resistance was detected in the hypomineralized tissue. In Group III, cavities designed as Group II, differently from this group deproteinization of the left hypomineralized tissue was performed prior to the placement of CRRs. Group IV served as the control group consisting of unaffected carious PFMs. Restorations were evaluated according to modified USPHS criteria for 24 months. RESULTS: The retention rates were 93.7% for Group I, 80.7% for Group II, 93.5% for Group III and 100% for Group IV. The success rate for the restorations in Group II proved significantly lower (p<0.05) than that of the other three groups. No significant difference in success rates was observed between Group I, Group III and Group IV (p>0.05) at the end of 24 months. CONCLUSIONS: Failure of the restorations was predominant in the group that the hypomineralized tissue was left surrounding the cavities. Deproteinization of the hypomineralized enamel was found to enhance the retention rates of CRRs.
[Mh] Termos MeSH primário: Resinas Compostas
Hipoplasia do Esmalte Dentário/terapia
Corrosão Dentária
Restauração Dentária Permanente
[Mh] Termos MeSH secundário: Criança
Proteínas do Esmalte Dentário/efeitos dos fármacos
Materiais Dentários
Seres Humanos
Ácidos Fosfóricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Composite Resins); 0 (Dental Enamel Proteins); 0 (Dental Materials); 0 (Phosphoric Acids); E4GA8884NN (phosphoric acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.17796/1053-4628-41.5.336


  8 / 5728 MEDLINE  
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[PMID]:28712552
[Au] Autor:Sesták J; Thormann W
[Ad] Endereço:Clinical Pharmacology Laboratory, Institute for Infectious Diseases, University of Bern, Bern, Switzerland; Institute of Analytical Chemistry of the Czech Academy of Sciences, v. v. i., Brno, Czechia.
[Ti] Título:Insights into head-column field-amplified sample stacking: Part II. Study of the behavior of the electrophoretic system after electrokinetic injection of cationic compounds across a short water plug.
[So] Source:J Chromatogr A;1512:124-132, 2017 Aug 25.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Part I on head-column field-amplified sample stacking comprised a detailed study of the electrokinetic injection of a weak base across a short water plug into a phosphate buffer at low pH. The water plug is converted into a low conductive acidic zone and cationic analytes become stacked at the interface between this and a newly formed phosphoric acid zone. The fundamentals of electrokinetic processes occurring thereafter were studied experimentally and with computer simulation and are presented as part II. The configuration analyzed represents a discontinuous buffer system. Computer simulation revealed that the phosphoric acid zone at the plug-buffer interface becomes converted into a migrating phosphate buffer plug which corresponds to the cationically migrating system zone of the phosphate buffer system. Its mobility is higher than that of the analytes such that they migrate behind the system zone in a phosphate buffer comparable to the applied background electrolyte. The temporal behaviour of the current and the conductivity across the water plug were monitored and found to reflect the changes in the low conductivity plug. Determination of the buffer flow in the capillary revealed increased pumping caused by the mismatch of electroosmosis within the low conductivity plug and the buffer. This effect becomes elevated with increasing water plug length. For plug lengths up to 1% of the total column length the flow quickly drops to the electroosmotic flow of the buffer and simulations with experimentally determined current and flow values predict negligible band dispersion and no loss of resolution for both low and large molecular mass components.
[Mh] Termos MeSH primário: Cátions/química
Eletrólitos/química
Eletroforese Capilar/instrumentação
Água/química
[Mh] Termos MeSH secundário: Tampões (Química)
Simulação por Computador
Eletro-Osmose
Eletroforese Capilar/métodos
Ácidos Fosfóricos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Buffers); 0 (Cations); 0 (Electrolytes); 0 (Phosphoric Acids); 059QF0KO0R (Water); E4GA8884NN (phosphoric acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE


  9 / 5728 MEDLINE  
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[PMID]:28650791
[Au] Autor:Hasija P; Sachdev V; Mathur S; Rath R
[Ti] Título:Deproteinizing Agents as an Effective Enamel Bond Enhancer-An in Vitro Study.
[So] Source:J Clin Pediatr Dent;41(4):280-283, 2017.
[Is] ISSN:1053-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study was to compare the effect of different deproteinizing agents on shear bond strength of composite to primary teeth enamel. STUDY DESIGN: Forty sound primary molars divided in 4 groups of 10 teeth each. In control group 1, enamel was etched for 60 seconds with 37% phosphoric acid and rinsed with water. Group 2: after acid etching deproteinizing agent 5 % sodium hypochlorite was applied for 60 seconds and rinsed. Group 3: after acid etching deproteinizing agent papain gel was applied for 60 seconds and rinsed. Group 4: after acid etching deproteinizing agent bromelain gel applied for 60 seconds and rinsed. Following this, bonding agent was applied to treated enamel surface and composite resin disc were build. Samples were then tested for shear bond strength using Universal Testing Machine. RESULTS: Mean SBS was highest for group 4 and lowest for group 1. No statistically significant difference (p value >0.05) was found between all the four groups. CONCLUSION: Among deproteinizing agents, deproteinization when carried out with bromelain gel and sodium hypochlorite showed effective bond strength as compared to papain.
[Mh] Termos MeSH primário: Ataque Ácido Dentário/métodos
Bromelaínas/farmacologia
Colagem Dentária/métodos
Papaína/farmacologia
Ácidos Fosfóricos/farmacologia
Hipoclorito de Sódio/farmacologia
[Mh] Termos MeSH secundário: Seres Humanos
Resistência ao Cisalhamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphoric Acids); 9001-00-7 (Bromelains); DY38VHM5OD (Sodium Hypochlorite); EC 3.4.22.2 (Papain)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE
[do] DOI:10.17796/1053-4628-41.4.280


  10 / 5728 MEDLINE  
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[PMID]:28552336
[Au] Autor:Vejlegaard K; Paul S; Kosbar T; Wengel J; Caruthers MH
[Ad] Endereço:Biomolecular Nanoscale Engineering Center, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.
[Ti] Título:Oligodeoxynucleotides containing 2'-amino-LNA nucleotides as constrained morpholino phosphoramidate and phosphorodiamidate monomers.
[So] Source:Bioorg Med Chem Lett;27(14):3173-3176, 2017 07 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Incorporation in a 2'→5' direction of a phosphorodiamidite 2'-amino-LNA-T nucleotide as the morpholino phosphoramidate and N,N-dimethylamino phosphorodiamidate monomers into six oligonucleotides is reported. Thermal denaturation studies showed that the novel 2'-amino-LNA-based morpholino monomers exert a destabilizing effects on duplexes formed with complementary DNA and RNA.
[Mh] Termos MeSH primário: Amidas/química
Morfolinos/química
Oligodesoxirribonucleotídeos/química
Oligonucleotídeos/química
Ácidos Fosfóricos/química
[Mh] Termos MeSH secundário: DNA/química
DNA/metabolismo
Simulação de Dinâmica Molecular
Morfolinos/metabolismo
Conformação de Ácido Nucleico
Desnaturação de Ácido Nucleico
Oligodesoxirribonucleotídeos/metabolismo
Temperatura de Transição
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amides); 0 (Morpholinos); 0 (Oligodeoxyribonucleotides); 0 (Oligonucleotides); 0 (Phosphoric Acids); 0 (amino-LNA); 9007-49-2 (DNA); 9Q189608GB (phosphoramidic acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE



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