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[PMID]:28968924
[Au] Autor:Zvobgo G; LwalabaWaLwalaba J; Sagonda T; Mutemachani Mapodzeke J; Muhammad N; Haider Shamsi I; Zhang G
[Ad] Endereço:Department of Agronomy, College of Agriculture and Biotechnology, Key Laboratory of Crop Germplasm Resource, Zhejiang University, Hangzhou 310058, PR China.
[Ti] Título:Phosphate alleviates arsenate toxicity by altering expression of phosphate transporters in the tolerant barley genotypes.
[So] Source:Ecotoxicol Environ Saf;147:832-839, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The contribution of the phosphate transporters (PHTs) in uptake of arsenate (As ) and phosphate (P) is a widely recognized mechanism. Here we investigated how P regulates the uptake of As and the subsequent effects on growth and relative expression of PHTs. The study was conducted on 3 barley genotypes differing in As tolerance (ZDB160, As-tolerant; ZDB115, moderately tolerant; ZDB475, As-sensitive) using a hydroponic experiment. There were 3 As (0, 10 and 100µM) and 3P (0, 50 and 500µM) levels. The results showed that the negative effect of As stress on plant growth, photosynthesis and cell ultra-structure is As dose and barley genotype dependent, confirming the distinctly genotypic difference in As tolerance. As uptake and accumulation in plant tissues are closely associated with inhibited extent of growth and photosynthesis, with the tolerant genotype ZDB160 having lower As content than other two genotypes. The toxic effect caused by As stress could be alleviated by P addition, mainly due to reduced As uptake. Moreover, the tolerant genotype showed relatively lower expression PHTs than sensitive ones upon exposure to both As stress and P addition, suggesting regulation of PHTs expression is a major mechanism for relative uptake of As and P, in subsequence affecting As tolerance. Moreover, among 6 PHTs examined in this study, the expressions of PHT1.3, PHT1.4 and PHT1.6 showed the marked difference among the three barley genotypes in responses to As stress and P addition, indicating further research on the contribution of phosphate transporters to As and P uptake should be focused on these PHTs.
[Mh] Termos MeSH primário: Adaptação Biológica
Arseniatos/toxicidade
Regulação da Expressão Gênica de Plantas/efeitos dos fármacos
Hordeum/metabolismo
Proteínas de Transporte de Fosfato/genética
Fosfatos/farmacologia
Poluentes do Solo/toxicidade
[Mh] Termos MeSH secundário: Adaptação Biológica/genética
Arseniatos/metabolismo
Biomassa
Genótipo
Hordeum/genética
Hordeum/crescimento & desenvolvimento
Modelos Teóricos
Fosfatos/metabolismo
Fotossíntese/efeitos dos fármacos
Poluentes do Solo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenates); 0 (Phosphate Transport Proteins); 0 (Phosphates); 0 (Soil Pollutants)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE


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[PMID]:28461450
[Au] Autor:Rothstein DM; Lazinski D; Osburne MS; Sonenshein AL
[Ad] Endereço:Graduate Program in Molecular Biology, Tufts University School of Medicine, Boston, Massachusetts, USA.
[Ti] Título:A Mutation in the Bacillus subtilis rsbU Gene That Limits RNA Synthesis during Sporulation.
[So] Source:J Bacteriol;199(14), 2017 07 15.
[Is] ISSN:1098-5530
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mutants of that are temperature sensitive for RNA synthesis during sporulation were isolated after selection with a P suicide agent. Whole-genome sequencing revealed that two of the mutants carried an identical lesion in the gene, which encodes a phosphatase that indirectly activates SigB, the stress-responsive RNA polymerase sigma factor. The mutation appeared to cause RsbU to be hyperactive, because the mutants were more resistant than the parent strain to ethanol stress. In support of this hypothesis, pseudorevertants that regained wild-type levels of sporulation at high temperature had secondary mutations that prevented expression of the mutant gene. The properties of these RsbU mutants support the idea that activation of SigB diminishes the bacterium's ability to sporulate. Most bacterial species encode multiple RNA polymerase promoter recognition subunits (sigma factors). Each sigma factor directs RNA polymerase to different sets of genes; each gene set typically encodes proteins important for responses to specific environmental conditions, such as changes in temperature, salt concentration, and nutrient availability. A selection for mutants of that are temperature sensitive for RNA synthesis during sporulation unexpectedly yielded strains with a point mutation in , a gene that encodes a protein that normally activates sigma factor B (SigB) under conditions of salt stress. The mutation appears to cause RsbU, and therefore SigB, to be active inappropriately, thereby inhibiting, directly or indirectly, the ability of the cells to transcribe sporulation genes.
[Mh] Termos MeSH primário: Bacillus subtilis/metabolismo
Proteínas de Bactérias/metabolismo
Regulação Bacteriana da Expressão Gênica/fisiologia
Monoéster Fosfórico Hidrolases/metabolismo
RNA Bacteriano/biossíntese
Esporos Bacterianos/fisiologia
[Mh] Termos MeSH secundário: Bacillus subtilis/genética
Proteínas de Bactérias/genética
Etanol/farmacologia
Genoma Bacteriano
Temperatura Alta
Mutação
Fosfatos/metabolismo
Monoéster Fosfórico Hidrolases/genética
Radioisótopos de Fósforo
Estresse Fisiológico/efeitos dos fármacos
Estresse Fisiológico/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Phosphates); 0 (Phosphorus Radioisotopes); 0 (RNA, Bacterial); 3K9958V90M (Ethanol); EC 3.1.3.2 (Phosphoric Monoester Hydrolases); EC 3.1.3.3 (RsbU protein, Bacillus subtilis)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:28985540
[Au] Autor:Wang YS; Dai JG; Wang L; Tsang DCW; Poon CS
[Ad] Endereço:Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hong Kong, China.
[Ti] Título:Influence of lead on stabilization/solidification by ordinary Portland cement and magnesium phosphate cement.
[So] Source:Chemosphere;190:90-96, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Inorganic binder-based stabilization/solidification (S/S) of Pb-contaminated soil is a commonly used remediation approach. This paper investigates the influences of soluble Pb species on the hydration process of two types of inorganic binders: ordinary Portland cement (OPC) and magnesium potassium phosphate cement (MKPC). The environmental leachability, compressive strength, and setting time of the cement products are assessed as the primary performance indicators. The mechanisms of Pb involved in the hydration process are analyzed through X-ray diffraction (XRD), hydration heat evolution, and thermogravimetric analyses. Results show that the presence of Pb imposes adverse impact on the compressive strength (decreased by 30.4%) and the final setting time (prolonged by 334.7%) of OPC, but it exerts much less influence on those of MKPC. The reduced strength and delayed setting are attributed to the retarded hydration reaction rate of OPC during the induction period. These results suggest that the OPC-based S/S of soluble Pb mainly depends on physical encapsulation by calcium-silicate-hydrate (CSH) gels. In contrast, in case of MKPC-based S/S process, chemical stabilization with residual phosphate (pyromorphite and lead phosphate precipitation) and physical fixation of cementitious struvite-K are the major mechanisms. Therefore, MKPC is a more efficient and chemically stable inorganic binder for the Pb S/S process.
[Mh] Termos MeSH primário: Materiais de Construção
Chumbo/química
Compostos de Magnésio/química
Fosfatos/química
Poluentes do Solo/química
[Mh] Termos MeSH secundário: Compostos de Cálcio
Géis/química
Minerais/química
Compostos de Potássio/química
Silicatos
Poluentes Químicos da Água/química
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium Compounds); 0 (Gels); 0 (Magnesium Compounds); 0 (Minerals); 0 (Phosphates); 0 (Potassium Compounds); 0 (Silicates); 0 (Soil Pollutants); 0 (Water Pollutants, Chemical); 12190-77-1 (pyromorphite); 2P299V784P (Lead); 453COF7817 (magnesium phosphate); 62I1T06190 (lead phosphate); B7862WZ632 (potassium phosphate); S4255P4G5M (calcium silicate)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


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[PMID]:28464802
[Au] Autor:Neradova A; Schumacher SP; Hubeek I; Lux P; Schurgers LJ; Vervloet MG
[Ad] Endereço:Department of Nephrology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. a.neradova@vumc.nl.
[Ti] Título:Phosphate binders affect vitamin K concentration by undesired binding, an in vitro study.
[So] Source:BMC Nephrol;18(1):149, 2017 May 02.
[Is] ISSN:1471-2369
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Vascular calcification is a major contributing factor to mortality in end stage renal disease (ESRD). Despite the efficacy of phosphate binders to improve hyperphosphatemia, data on vascular calcification are less clear. There seems to be a difference in attenuation or delay in progression between different binders. In this in vitro experiment we tested whether phosphate binders could limit bioavailability of vitamin K2 by undesired binding. Vitamin K-deficiency limits activation of the vascular tissue mineralization inhibitor matrix γ-carboxyglutamate (Gla) protein (MGP) thereby exacerbating vascular calcification. METHODS: In this experiment vitamin K2 (menaquinone-7; MK-7) binding was assessed by adding 1 mg of vitamin K2 to a medium with pH 6 containing 67 mg phosphate binder with either 7 mg of phosphate or no phosphate. Five different phosphate binders were tested. After five and a half hours vitamin K was analyzed by HPLC. All experiments were performed in triplicate. RESULTS: Sucroferric-oxyhydroxide and sevelamer carbonate did not significantly bind vitamin K2, both in solution only containing vitamin K2 or in combination with phosphate. Calcium acetate/magnesium carbonate binds vitamin K2 strongly both in absence (p = 0.001) and presence of phosphate (p = 0.003). Lanthanum carbonate significantly binds vitamin K2 in solution containing only vitamin K2 (p = 0.005) whereas no significant binding of vitamin K2 was observed in the solution containing vitamin K2 and phosphate (p = 0.462). Calcium carbonate binds vitamin K2 significantly in a solution with vitamin K2 and phosphate (p = 0.009) whereas without phosphate no significant binding of vitamin K2 was observed (p = 0.123). CONCLUSIONS: Sucroferric-oxyhydroxide and sevelamer carbonate were the only binders of the five binders studied that did not bind vitamin K2 in vitro. The presence or absence of phosphate significantly interferes with vitamin K2 binding so phosphate binders could potentially limit bioavailability vitamin K2.
[Mh] Termos MeSH primário: Quelantes/química
Fosfatos/química
Vitamina K/química
[Mh] Termos MeSH secundário: Ligação Proteica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chelating Agents); 0 (Phosphates); 12001-79-5 (Vitamin K)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s12882-017-0560-3


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[PMID]:29478656
[Au] Autor:Zhang L; Liu J; Guo X
[Ad] Endereço:Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
[Ti] Título:Investigation on mechanism of phosphate removal on carbonized sludge adsorbent.
[So] Source:J Environ Sci (China);64:335-344, 2018 Feb.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:For the removal of phosphate (PO ) from water, an adsorbent was prepared via carbonization of sewage sludge from a wastewater treatment plant: carbonized sludge adsorbent (CSA). The mechanism of phosphate removal was determined after studying the structure and chemical properties of the CSA and its influence on phosphate removal. The results demonstrate that phosphate adsorption by the CSA can be fitted with the pseudo second-order kinetics and Langmuir isotherm models, indicating that the adsorption is single molecular layer adsorption dominated by chemical reaction. The active sites binding phosphate on the surface are composed of mineral particles containing Si/Ca/Al/Fe. The mineral containing Ca, calcite, is the main factor responsible for phosphate removal. The phosphate removal mechanism is a complex process including crystallization via the interaction between Ca and PO ; formation of precipitates of Ca , Al , and PO ; and adsorption of PO on some recalcitrant oxides composed of Si/Al/Fe.
[Mh] Termos MeSH primário: Fosfatos/química
Eliminação de Resíduos Líquidos/métodos
Águas Residuais/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Adsorção
Fosfatos/análise
Esgotos/química
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphates); 0 (Sewage); 0 (Waste Water); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE


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[PMID]:29311459
[Au] Autor:Mitsuboshi S; Yamada H; Nagai K; Okajima H
[Ad] Endereço:Department of Pharmacy, Kaetsu Hospital.
[Ti] Título:[Low Continuity Rate of Sucroferric Oxyhydroxide among Japanese Hemodialysis Patients with High Phosphate Binder Pill Burden].
[So] Source:Yakugaku Zasshi;138(1):135-139, 2018.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:This prospective observational study was conducted to evaluate the continuity, efficacy, and tolerability of sucroferric oxyhydroxide (SO) among hemodialysis (HD) patients who switched to SO from sevelamer hydrochloride (SH) or bixalomer (BX). Participants were 9 HD patients in Kaetsu Hospital who had been receiving more than 9 tablets/d of SH or BX and were switched to SO 750 mg/d. All the participants were men. Over a 6-month observational period, 6 of the 9 patients (67%) discontinued SO because of adverse events, including diarrhea, atheroma, and polycythemia. Although the diarrhea and atheroma were mild, the affected patients did not wish to restart SO. On the other hand, 3 of the 9 patients (33%) continued taking SO throughout the observation period. These patients tended to have increased levels of serum calcium, hematocrit, and serum ferritin; a decreased number of phosphate binder tablets (from 21 tablets/d to 8 tablets/d); and a decreased dosage of erythropoiesis-stimulating agents. Serum phosphate levels tended to decrease in continuers, but tended to increase in discontinuers. It may be preferable to increase the SO dosage gradually rather than switching from SH or BX all at once, and patients who switch to SO should be carefully monitored.
[Mh] Termos MeSH primário: Quelantes/administração & dosagem
Esquema de Medicação
Substituição de Medicamentos/métodos
Compostos Férricos/administração & dosagem
Poliaminas
Diálise Renal
Sevelamer
Sacarose/administração & dosagem
[Mh] Termos MeSH secundário: Idoso
Grupo com Ancestrais do Continente Asiático
Quelantes/efeitos adversos
Combinação de Medicamentos
Compostos Férricos/efeitos adversos
Seres Humanos
Masculino
Meia-Idade
Fosfatos/sangue
Estudos Prospectivos
Sacarose/efeitos adversos
Comprimidos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Chelating Agents); 0 (Drug Combinations); 0 (Ferric Compounds); 0 (Phosphates); 0 (Polyamines); 0 (Tablets); 0 (sucroferric oxyhydroxide); 3160WY51LV (bixalomer); 57-50-1 (Sucrose); 9YCX42I8IU (Sevelamer)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00180


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[PMID]:29304096
[Au] Autor:Gravesen E; Lerche Mace M; Nordholm A; Hofman-Bang J; Hruska K; Haagen Nielsen C; Kjær A; Olgaard K; Lewin E
[Ad] Endereço:Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
[Ti] Título:Exogenous BMP7 in aortae of rats with chronic uremia ameliorates expression of profibrotic genes, but does not reverse established vascular calcification.
[So] Source:PLoS One;13(1):e0190820, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hyperphosphatemia and vascular calcification are frequent complications of chronic renal failure and bone morphogenetic protein 7 (BMP7) has been shown to protect against development of vascular calcification in uremia. The present investigation examined the potential reversibility of established uremic vascular calcification by treatment of uremic rats with BMP7. A control model of isogenic transplantation of a calcified aorta from uremic rats into healthy littermates examined whether normalization of the uremic environment reversed vascular calcification. Uremia and vascular calcification were induced in rats by 5/6 nephrectomy, high phosphate diet and alfacalcidol treatment. After 14 weeks severe vascular calcification was present and rats were allocated to BMP7, vehicle or aorta transplantation. BMP7 treatment caused a significant decrease of plasma phosphate to 1.56 ± 0.17 mmol/L vs 2.06 ± 0.34 mmol/L in the vehicle group even in the setting of uremia and high phosphate diet. Uremia and alfacalcidol resulted in an increase in aortic expression of genes related to fibrosis, osteogenic transformation and extracellular matrix calcification, and the BMP7 treatment resulted in a decrease in the expression of profibrotic genes. The total Ca-content of the aorta was however unchanged both in the abdominal aorta: 1.9 ± 0.6 µg/mg tissue in the vehicle group vs 2.2 ± 0.6 µg/mg tissue in the BMP7 group and in the thoracic aorta: 71 ± 27 µg/mg tissue in the vehicle group vs 54 ± 18 µg/mg tissue in the BMP7 group. Likewise, normalization of the uremic environment by aorta transplantation had no effect on the Ca-content of the calcified aorta: 16.3 ± 0.6 µg/mg tissue pre-transplantation vs 15.9 ± 2.3 µg/mg tissue post-transplantation. Aortic expression of genes directly linked to extracellular matrix calcification was not affected by BMP7 treatment, which hypothetically might explain persistent high Ca-content in established vascular calcification. The present results highlight the importance of preventing the development of vascular calcification in chronic kidney disease. Once established, vascular calcification persists even in the setting when hyperphosphatemia or the uremic milieu is abolished.
[Mh] Termos MeSH primário: Proteína Morfogenética Óssea 7/farmacologia
Regulação da Expressão Gênica/efeitos dos fármacos
Uremia/tratamento farmacológico
Calcificação Vascular/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Aorta/efeitos dos fármacos
Aorta/metabolismo
Proteína Morfogenética Óssea 7/uso terapêutico
Doença Crônica
Fibrose
Masculino
Fosfatos/sangue
Ratos
Reação em Cadeia da Polimerase em Tempo Real
Uremia/genética
Microtomografia por Raio-X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bone Morphogenetic Protein 7); 0 (Phosphates)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190820


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[PMID]:29338022
[Au] Autor:Schreiber PW; Bischoff-Ferrari HA; Boggian K; Bonani M; van Delden C; Enriquez N; Fehr T; Garzoni C; Hirsch HH; Hirzel C; Manuel O; Meylan P; Saleh L; Weisser M; Mueller NJ; Swiss Transplant Cohort Study (STCS)
[Ad] Endereço:University Hospital Zurich and University Zurich, Division of Infectious Diseases and Hospital Epidemiology, Zurich, Switzerland.
[Ti] Título:Bone metabolism dynamics in the early post-transplant period following kidney and liver transplantation.
[So] Source:PLoS One;13(1):e0191167, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bone disease contributes to relevant morbidity after solid organ transplantation. Vitamin D has a crucial role for bone metabolism. Activation of vitamin D depends on the endocrine function of both, liver and kidney. Our study assessed key markers of bone metabolism at time of transplantation and 6 months after transplantation among 70 kidney and 70 liver recipients. In 70 kidney recipients 25-OH vitamin D levels did not differ significantly between peri-transplant (median 32.5nmol/l) and 6 months post-transplant (median 41.9nmol/l; P = 0.272). Six months post-transplant median 1, 25-(OH)2 vitamin D levels increased by >300% (from 9.1 to 36.5ng/l; P<0.001) and median intact parathyroid hormone levels decreased by 68.4% (from 208.7 to 66.0 ng/l; P<0.001). Median ß-Crosslaps (CTx) and total procollagen type 1 amino-terminal propeptide (P1NP) decreased by 65.1% (from 1.32 to 0.46ng/ml; P<0.001) and 60.6% (from 158.2 to 62.3ng/ml; P<0.001), respectively. Kidney recipients with incident fractures had significantly lower levels of 1, 25-(OH)2 vitamin D at time of transplantation and of intact parathyroid hormone 6 months post-transplant. Among 70 liver recipients, 25-OH vitamin D, 1, 25-(OH)2 vitamin D and intact parathyroid hormone levels were not significantly altered between peri-transplant and 6 months post-transplant. Contrary to kidney recipients, median CTx increased by 60.0% (from 0.45 to 0.72 ng/ml; P = 0.002) and P1NP by 49.3% (from 84.0 to 125.4ng/ml; P = 0.001) in the longitudinal course. Assessed biomarkers didn't differ between liver recipients with and without fractures. To conclude, the assessed panel of biomarkers proved highly dynamic after liver as well as kidney transplantation in the early post-transplant period. After kidney transplantation a significant gain in 1, 25-(OH)2 vitamin D combined with a decline in iPTH, CTx and P1NP, whereas after liver transplantation an increase in CTx and P1NP were characteristic.
[Mh] Termos MeSH primário: Osso e Ossos/metabolismo
Transplante de Rim
Transplante de Fígado
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/sangue
Densidade Óssea
Remodelação Óssea/fisiologia
Colágeno Tipo I/sangue
Feminino
Fraturas Ósseas/etiologia
Taxa de Filtração Glomerular
Seres Humanos
Transplante de Rim/efeitos adversos
Transplante de Fígado/efeitos adversos
Masculino
Meia-Idade
Hormônio Paratireóideo/sangue
Fragmentos de Peptídeos/sangue
Peptídeos/sangue
Fosfatos/sangue
Pró-Colágeno/sangue
Estudos Prospectivos
Vitamina D/análogos & derivados
Vitamina D/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Collagen Type I); 0 (PTH protein, human); 0 (Parathyroid Hormone); 0 (Peptide Fragments); 0 (Peptides); 0 (Phosphates); 0 (Procollagen); 0 (collagen type I trimeric cross-linked peptide); 0 (procollagen Type I N-terminal peptide); 1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D); 66772-14-3 (1,25-dihydroxyvitamin D)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191167


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[PMID]:28992478
[Au] Autor:Shen Z; Tian D; Zhang X; Tang L; Su M; Zhang L; Li Z; Hu S; Hou D
[Ad] Endereço:College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing, Jiangsu, 210095, China; Geotechnical and Environmental Research Group, Department of Engineering, University of Cambridge, Cambridge, CB2 1PZ, United Kingdom; Department of Earth and Atmospheric Sciences, Univ
[Ti] Título:Mechanisms of biochar assisted immobilization of Pb by bioapatite in aqueous solution.
[So] Source:Chemosphere;190:260-266, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bioapatite (BAp) is regarded as an effective material to immobilize lead (Pb ) via the formation of stable pyromorphite. However, when applied in contaminated soil, due to its low surface area and low adsorption capacity, BAp might not sufficiently contact and react with Pb . Biochar, a carbon storage material, typically has high surface area and high adsorption capacity. This study investigated the feasibility of using biochar as a reaction platform to enhance BAp immobilization of Pb . An alkaline biochar produced from wheat straw pellets (WSP) and a slightly acidic biochar produced from hardwood (SB) were selected. The results of aqueous adsorption showed the combination of biochar (WSP or SB) and BAp effectively removed Pb from the aqueous solution containing 1000 ppm Pb . XRD, ATR-IR, and SEM/EDX results revealed the formation of hydroxypyromorphite on both biochars' surfaces. This study demonstrates that biochars could act as an efficient reaction platform for BAp and Pb in aqueous solution due to their high surface area, porous structure, and high adsorption capacity. Therefore, it is mechanistically feasible to apply biochar to enhance BAp immobilization of Pb in contaminated soil.
[Mh] Termos MeSH primário: Carvão Vegetal/química
Recuperação e Remediação Ambiental/métodos
Chumbo/isolamento & purificação
Poluentes do Solo/isolamento & purificação
[Mh] Termos MeSH secundário: Adsorção
Carbono
Minerais/química
Fosfatos/química
Triticum/química
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Minerals); 0 (Phosphates); 0 (Soil Pollutants); 0 (biochar); 059QF0KO0R (Water); 12190-77-1 (pyromorphite); 16291-96-6 (Charcoal); 2P299V784P (Lead); 7440-44-0 (Carbon)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171010
[St] Status:MEDLINE


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[PMID]:29269259
[Au] Autor:Ali GW; El-Hotaby W; Hemdan B; Abdel-Fattah WI
[Ad] Endereço:Refractories, Ceramics, Building Materials, Dept. Biomaterials Group, Inorganic and Mineral Resources Division, National Research Centre, Egypt. Electronic address: wafaaghareib@gmail.com.
[Ti] Título:Thermosensitive chitosan/phosphate hydrogel-composites fortified with Ag versus Ag@Pd for biomedical applications.
[So] Source:Life Sci;194:185-195, 2018 Feb 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Thermo-responsive hydrogels are promising biomedical systems as their gelation is triggered by temperature changes. Greenly synthesized noble metallic nanoparticles are a growing research area assessing their potential applications in nanomedicine. MATERIALS AND METHODS: Chitosan/phosphate thermosensitive gels were successfully achieved. The developed composite scaffolds were functionalized with the greenly synthesized Ag or Ag@Pd targeting improved bactericidal activity and biocompatibility performance. The physicochemical characterization was assessed through TGA, DSC, FESEM, HRTEM, XRD and FTIR. Bactericidal activities were tested against gram- positive Staphylococcus aureus and gram-negative Pseudomonas aeruginosa. Their biodegradability upon DMEM immersion was followed up to seven days through measuring ionic concentrations of Ca, P, Ag and Pd successively. KEY FINDINGS: The newly developed phosphatic layers over the scaffold surfaces post-immersion assessed their osteogenic ability. Further, their promising and differentiated bactericidal activities due to the noble metals incorporation were proved. Cytotoxicity assessment demonstrated their high biocompatibility since no toxic effect was recorded. SIGNIFICANCE: Consequently, they can be successfully and directly applied in biomedical and dental surgeries.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Quitosana/análogos & derivados
Preparações de Ação Retardada/química
Hidrogéis/química
Paládio/administração & dosagem
Prata/administração & dosagem
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Bactérias/efeitos dos fármacos
Infecções Bacterianas/tratamento farmacológico
Células Hep G2
Seres Humanos
Células MCF-7
Nanopartículas Metálicas/administração & dosagem
Paládio/farmacologia
Fosfatos/química
Prata/farmacologia
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Delayed-Action Preparations); 0 (Hydrogels); 0 (Phosphates); 3M4G523W1G (Silver); 5TWQ1V240M (Palladium); 9012-76-4 (Chitosan)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171223
[St] Status:MEDLINE



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