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Pesquisa : D01.029.260.700.675.374.075.150 [Categoria DeCS]
Referências encontradas : 918 [refinar]
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[PMID]:28774457
[Au] Autor:Jacques T; Michelin P; Badr S; Nasuto M; Lefebvre G; Larkman N; Cotten A
[Ad] Endereço:Division of Radiology and Musculoskeletal Imaging, University Hospital of Lille, Rue du Professeur Emile Laine, Lille Cedex 59037, France; University of Lille, 42, rue Paul Duez, Lille 59000, France. Electronic address: thib.jacques@gmail.com.
[Ti] Título:Conventional Radiology in Crystal Arthritis: Gout, Calcium Pyrophosphate Deposition, and Basic Calcium Phosphate Crystals.
[So] Source:Radiol Clin North Am;55(5):967-984, 2017 Sep.
[Is] ISSN:1557-8275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This article reviews the main radiographic features of crystal deposition diseases. Gout is linked to monosodium urate crystals. Classic radiographic features include subcutaneous tophi, large and well-circumscribed paraarticular bone erosions, and exuberant bone hyperostosis. Calcium pyrophosphate deposition (CPPD) can involve numerous structures, such as hyaline cartilages, fibrocartilages, or tendons. CPPD arthropathy involves joints usually spared by osteoarthritis. Basic calcium phosphate deposits are periarticular or intraarticular. Periarticular calcifications are amorphous, dense, and round or oval with well-limited borders, and most are asymptomatic. When resorbing, they become cloudy and less dense with an ill-defined shape and can migrate into adjacent structures.
[Mh] Termos MeSH primário: Fosfatos de Cálcio/metabolismo
Pirofosfato de Cálcio/metabolismo
Artropatias por Cristais/diagnóstico por imagem
Artropatias por Cristais/metabolismo
Radiologia
[Mh] Termos MeSH secundário: Gota/diagnóstico por imagem
Gota/metabolismo
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Calcium Phosphates); 97Z1WI3NDX (calcium phosphate); X69NU20D19 (Calcium Pyrophosphate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE


  2 / 918 MEDLINE  
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[PMID]:28373994
[Au] Autor:Rada B
[Ad] Endereço:College of Veterinary Medicine, Department of Infectious Diseases, The University of Georgia, Athens, GA, USA.
[Ti] Título:Neutrophil Extracellular Traps and Microcrystals.
[So] Source:J Immunol Res;2017:2896380, 2017.
[Is] ISSN:2314-7156
[Cp] País de publicação:Egypt
[La] Idioma:eng
[Ab] Resumo:Neutrophil extracellular traps represent a fascinating mechanism by which PMNs entrap extracellular microbes. The primary purpose of this innate immune mechanism is thought to localize the infection at an early stage. Interestingly, the ability of different microcrystals to induce NET formation has been recently described. Microcrystals are insoluble crystals with a size of 1-100 micrometers that have different composition and shape. Microcrystals have it in common that they irritate phagocytes including PMNs and typically trigger an inflammatory response. This review is the first to summarize observations with regard to PMN activation and NET release induced by microcrystals. Gout-causing monosodium urate crystals, pseudogout-causing calcium pyrophosphate dehydrate crystals, cholesterol crystals associated with atherosclerosis, silicosis-causing silica crystals, and adjuvant alum crystals are discussed.
[Mh] Termos MeSH primário: Armadilhas Extracelulares/imunologia
Neutrófilos/fisiologia
[Mh] Termos MeSH secundário: Compostos de Alúmen/química
Animais
Pirofosfato de Cálcio/química
Colesterol/química
Cristalização
Seres Humanos
Ativação de Neutrófilo
Neutrófilos/imunologia
Tamanho da Partícula
Dióxido de Silício/química
Ácido Úrico/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alum Compounds); 268B43MJ25 (Uric Acid); 34S289N54E (aluminum sulfate); 7631-86-9 (Silicon Dioxide); 97C5T2UQ7J (Cholesterol); X69NU20D19 (Calcium Pyrophosphate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.1155/2017/2896380


  3 / 918 MEDLINE  
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[PMID]:27941391
[Au] Autor:Carlson AK; McCutchen CN; June RK
[Ad] Endereço:aDepartment of Cell Biology & Neuroscience bDepartment of Mechanical & Industrial Engineering, Montana State University, Bozeman, Montana, USA.
[Ti] Título:Mechanobiological implications of articular cartilage crystals.
[So] Source:Curr Opin Rheumatol;29(2):157-162, 2017 Mar.
[Is] ISSN:1531-6963
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: Calcium crystals exist in both pathological and normal articular cartilage. The prevalence of these crystals dramatically increases with age, and crystals are typically found in osteoarthritic cartilage and synovial fluid. Relatively few studies have examined the effects of crystals on cartilage biomechanics or chondrocyte mechanotransduction. The purpose of this review is to describe how crystals could influence cartilage biomechanics and mechanotransduction in osteoarthritis. RECENT FINDINGS: Crystals are found in both loaded and unloaded regions of articular cartilage. Exogenous crystals, in combination with joint motion, result in substantial joint inflammation. Articular cartilage vesicles promote crystal formation, and these vesicles are found near the periphery of chondrocytes. Crystallographic studies report monoclinic symmetry for synthetic crystals, suggesting that crystals will have a large stiffness compared with the cartilage extracellular matrix, the pericellular matrix, or the chondrocyte. This stiffness imbalance may cause crystal-induced dysregulation of chondrocyte mechanotransduction promoting both aging and osteoarthritis chondrocyte phenotypes. SUMMARY: Because of their high stiffness compared with cartilage matrix, crystals likely alter chondrocyte mechanotransduction, and high concentrations of crystals within cartilage may alter macroscale biomechanics. Future studies should focus on understanding the mechanical properties of joint crystals and developing methods to understand how crystals affect chondrocyte mechanotransduction.
[Mh] Termos MeSH primário: Fosfatos de Cálcio/metabolismo
Pirofosfato de Cálcio/metabolismo
Cartilagem Articular/metabolismo
Condrocalcinose/metabolismo
Condrócitos/metabolismo
Matriz Extracelular/metabolismo
Osteoartrite/metabolismo
[Mh] Termos MeSH secundário: Cartilagem Articular/citologia
Cartilagem Articular/fisiopatologia
Condrocalcinose/fisiopatologia
Condrócitos/citologia
Seres Humanos
Mecanotransdução Celular/fisiologia
Osteoartrite/fisiopatologia
Estresse Mecânico
Suporte de Carga
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Calcium Phosphates); 97Z1WI3NDX (calcium phosphate); X69NU20D19 (Calcium Pyrophosphate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170720
[Lr] Data última revisão:
170720
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE
[do] DOI:10.1097/BOR.0000000000000368


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[PMID]:27837341
[Au] Autor:Berendsen D; Neogi T; Taylor WJ; Dalbeth N; Jansen TL
[Ad] Endereço:Department of Rheumatology, Ziekenhuisgroep Twente, Almelo, The Netherlands. d.berendsen@zgt.nl.
[Ti] Título:Crystal identification of synovial fluid aspiration by polarized light microscopy. An online test suggesting that our traditional rheumatologic competence needs renewed attention and training.
[So] Source:Clin Rheumatol;36(3):641-647, 2017 Mar.
[Is] ISSN:1434-9949
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Testing a reading exercise for identification of several typical crystal such as the negatively birefringent needle-shaped crystals that are under polarized light microscopy is the gold standard for diagnosing gout. The objective of this study was to assess current performance of crystal identification by professionals involved in examining synovial fluid in routine care. Rheumatologists, trainees, lab technicians, and other physicians with an interest in crystal arthritis completed an online test. The test consisted of 30 images: 8 monosodium urate (MSU) crystals, 5 calcium pyrophosphate (CPP), 4 cholesterol, 2 depot methylprednisolone, 2 calcium oxalate, 2 rice bodies, 1 hydroxyapatite, 1 liquid lipid, 1 fibrin, 1 Charcot-Leyden, and 5 different artifacts. Of the 22 non-MSU slides, a subset of 8 was pre-designated that were thought to be clinically important to be identified as non-MSU. The primary outcome was defined as the correct identification of all eight MSU slides plus the identification of all eight pre-defined non-MSU slides as non-MSU. The online test was completed by 110 participants. The primary outcome was achieved by 39%. Correct identification of all MSU images was achieved by 81%, correct identification of all 8 pre-defined non-MSU, CPP images, and all 22 non-MSU images as non-MSU by 68, 68, and 23%, respectively. MSU crystals were well identified, but incorrect identification of non-MSU crystals occurred frequently. This study suggests that there is room for improvement regarding crystal identification of particularly CPP and other non-MSU crystals even in this highly motivated group.
[Mh] Termos MeSH primário: Pirofosfato de Cálcio/análise
Competência Clínica/normas
Gota/diagnóstico
Reumatologia/normas
Líquido Sinovial/química
Ácido Úrico/análise
[Mh] Termos MeSH secundário: Seres Humanos
Microscopia de Polarização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
268B43MJ25 (Uric Acid); X69NU20D19 (Calcium Pyrophosphate)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161113
[St] Status:MEDLINE
[do] DOI:10.1007/s10067-016-3461-0


  5 / 918 MEDLINE  
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[PMID]:27660935
[Au] Autor:Frallonardo P; Oliviero F; Peruzzo L; Tauro L; Scanu A; Galozzi P; Ramonda R; Punzi L
[Ad] Endereço:From the *Rheumatology Unit, Department of Medicine-DIMED; †Institute of Geosciences and Earth Resources, National Research Council (CNR) of Italy, Padova, c/o Department of Geosciences; and ‡Department of Geosciences, University of Padova, Padova, Italy.
[Ti] Título:Detection of Calcium Crystals in Knee Osteoarthritis Synovial Fluid: A Comparison Between Polarized Light and Scanning Electron Microscopy.
[So] Source:J Clin Rheumatol;22(7):369-71, 2016 Oct.
[Is] ISSN:1536-7355
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The identification of calcium crystals in synovial fluid (SF) of patients with osteoarthritis (OA) represents an important step in understanding the role of these crystals in synovial inflammation and disease progression. OBJECTIVES: This study aimed to investigate the presence of calcium pyrophosphate (CPP) and basic calcium phosphate (BCP) crystals in SF collected from patients with symptomatic knee OA by scanning electron microscopy (SEM) coupled to x-ray energy dispersive spectroscopy, compensated polarized light microscopy (CPLM), and alizarin red staining. METHODS: Seventy-four patients with knee OA were included in the study. Synovial fluid samples were collected after arthrocentesis and examined under CPLM for the assessment of CPP crystals. Basic calcium phosphate crystals were evaluated by alizarin red staining. All the samples were examined by SEM. The concordance between the 2 techniques was evaluated by Cohen κ agreement coefficient. RESULTS: Calcium pyrophosphate and BCP crystals were found, respectively, in 23 (31.1%) and 13 (17.5%) of 74 OA SFs by SEM analysis. Calcium pyrophosphate crystals were identified in 23 (31.1%) of 74 samples by CPLM, whereas BCP crystals were suspected in 27 (36.4%) of 74 samples. According to κ coefficient, the concordance between CPLM and SEM was 0.83 for CPP, and that between alizarin red and SEM was 0.68 for BCP. CONCLUSIONS: The results of our study showed a high level of concordance between the 2 microscope techniques as regards CPP crystal identification and a lower agreement for BCP crystals. Although this finding highlights the difficulty in identifying BCP crystals by alizarin red staining, the use of SEM remains unsuitable to apply in the clinical setting. Because of the in vitro inflammatory effect of BCP crystals, further work on their analysis in SF could provide important information about the OA process.
[Mh] Termos MeSH primário: Fosfatos de Cálcio/metabolismo
Pirofosfato de Cálcio/metabolismo
Osteoartrite do Joelho/metabolismo
Líquido Sinovial/química
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Antraquinonas
Cristalização
Feminino
Seres Humanos
Masculino
Microscopia Eletrônica de Varredura
Microscopia de Polarização
Meia-Idade
Espectrometria por Raios X
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthraquinones); 0 (Calcium Phosphates); 60MEW57T9G (alizarin); 97Z1WI3NDX (calcium phosphate); X69NU20D19 (Calcium Pyrophosphate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160924
[St] Status:MEDLINE
[do] DOI:10.1097/RHU.0000000000000416


  6 / 918 MEDLINE  
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[PMID]:27586801
[Au] Autor:Abhishek A; Doherty M
[Ad] Endereço:Academic Rheumatology, University of Nottingham, U.K. abhishek.abhishek@nottingham.ac.uk.
[Ti] Título:Update on calcium pyrophosphate deposition.
[So] Source:Clin Exp Rheumatol;34(4 Suppl 98):32-8, 2016 Jul-Aug.
[Is] ISSN:0392-856X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Calcium pyrophosphate crystal deposition (CPPD) associates with ageing, osteoarthritis (OA), uncommon metabolic diseases, mutations and polymorphisms in the ankylosis human gene (ANKH). CPPD is frequently polyarticular, occurs due to a generalised articular predisposition, and the association between CPPD and OA is joint specific, for example CPPD associates with knee OA, but not with hip OA. Other recently identified associations include knee malalignment (knee CC), low cortical BMD and soft-tissue calcification. CPPD is generally asymptomatic. A recent study reported that knees with OA plus CC at the index joint, or at distant joints (in absence of index joint CC), were more likely to have attrition. CPPD can cause acute CPP crystal arthritis, chronic CPP crystal inflammatory arthritis, and is frequently present in joints with OA. Joint aspiration remains the gold standard for diagnosing CPPD, although other promising techniques are emerging. Patients with polyarticular or young onset CPPD should be screened for underlying metabolic abnormalities, however, such testing can be unrewarding. The treatment of CPPD is symptomatic. Acute CPP crystal arthritis is treated with rest, local application of ice-packs, joint aspiration, colchicine and/or intra-articular corticosteroid injection (once infection is excluded). Colchicine, low-dose corticosteroids, hydroxychloroquine and radiosynovectomy are recommended for the treatment of chronic or recurrent acute CPP crystal arthritis. Recent RCTs did not confirm any benefit from methotrexate, and although there is increasing interest in the use of anti-IL1 agents for acute or chronic CPP crystal arthritis, their efficacy has not been formally examined. Unlike gout, currently there are no treatments to eliminate CPP crystal deposits.
[Mh] Termos MeSH primário: Pirofosfato de Cálcio/metabolismo
Artropatias por Cristais/metabolismo
Articulações/metabolismo
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/uso terapêutico
Artroplastia de Substituição/instrumentação
Artropatias por Cristais/diagnóstico
Artropatias por Cristais/etiologia
Artropatias por Cristais/terapia
Cristalização
Seres Humanos
Prótese Articular
Articulações/efeitos dos fármacos
Articulações/cirurgia
Fatores de Risco
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); X69NU20D19 (Calcium Pyrophosphate)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170112
[Lr] Data última revisão:
170112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160903
[St] Status:MEDLINE


  7 / 918 MEDLINE  
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[PMID]:27495083
[Au] Autor:Morino T; Ogata T; Horiuchi H; Yamaoka S; Fukuda M; Miura H
[Ad] Endereço:aSpine Center, Ehime University School of Medicine bDepartment of Pediatrics, Ehime University School of Medicine cDepartment of Orthopedic Surgery, Ehime University School of Medicine, Shitsukawa, Tohon City, Ehime, Japan.
[Ti] Título:Eight years of follow-up after laminectomy of calcium pyrophosphate crystal deposition in the cervical yellow ligament of patient with Coffin-Lowry syndrome: A case report.
[So] Source:Medicine (Baltimore);95(31):e4468, 2016 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We report 8 years of follow-up after decompression to treat cervical myelopathy in a patient with Coffin-Lowry syndrome (CLS). CLS is a rare X-linked semidominant syndrome associated with growth and psychomotor retardation, general hypotonia, and skeletal abnormalities. In this patient, the spinal cord was compressed by calcium pyrophosphate crystal deposition in the cervical yellow ligament (YL). To date, only 1 report has described clinical features after surgery for calcified cervical YL in CLS. METHODS: A 15-year-old male with tetraplegia secondary to compression of the cervical spinal cord induced by a hypoplastic posterior arch of C1 and calcification of the YL from C2 to C7 was treated surgically with laminectomy from C1 to C7. The patient's history, clinical examination, imaging findings, and treatment are reported. The patient was incapable of speech because of mental retardation, so he could not describe his symptoms. Gait disturbance worsened over the 2 months before admission to our hospital. At admission, the patient could not move his extremities, and tendon reflexes of the upper and lower extremities were significantly increased. Computed tomography of the cervical spine showed YL calcification from C2 to C7. Magnetic resonance imaging showed consecutive compression of the cervical spinal cord. We diagnosed quadriplegia secondary to cervical cord damage and performed emergency surgery. RESULTS: During C1-C7 laminectomy, YL calcification in C2-C7 was observed. The calcification was confirmed as calcium pyrophosphate by crystal analysis. Quadriplegia gradually resolved, and almost disappeared by 2 weeks after the operation. Cervical hyperlordosis was observed in radiographs starting from 1 month after the operation, but it has not progressed and is not associated with any symptoms. CONCLUSIONS: The efficacy of decompression continued, and no postoperative complications have occurred during at least 8 years of follow-up.
[Mh] Termos MeSH primário: Vértebras Cervicais/cirurgia
Síndrome de Coffin-Lowry/complicações
Laminectomia
Ligamento Amarelo/cirurgia
Ossificação Heterotópica/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Pirofosfato de Cálcio/química
Descompressão Cirúrgica
Seguimentos
Seres Humanos
Ligamento Amarelo/patologia
Masculino
Ossificação Heterotópica/complicações
Quadriplegia/etiologia
Quadriplegia/cirurgia
Compressão da Medula Espinal/etiologia
Compressão da Medula Espinal/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
X69NU20D19 (Calcium Pyrophosphate)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160807
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000004468


  8 / 918 MEDLINE  
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[PMID]:27464775
[Au] Autor:Soloway S; Tucker BS
[Ad] Endereço:From the *Arthritis & Rheumatology Associates of South Jersey, PC, Vineland; and †Rothman Institute, Egg Harbor Township, NJ.
[Ti] Título:Calcium Pyrophosphate Dihydrate Deposition Disease in a Knee With Total Joint Replacement.
[So] Source:J Clin Rheumatol;22(5):277, 2016 Aug.
[Is] ISSN:1536-7355
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Artroplastia de Substituição/efeitos adversos
Artroscopia/métodos
Pirofosfato de Cálcio/análise
Condrocalcinose
Colchicina/administração & dosagem
Articulação do Joelho/diagnóstico por imagem
Complicações Pós-Operatórias
Membrana Sinovial/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Condrocalcinose/diagnóstico
Condrocalcinose/tratamento farmacológico
Condrocalcinose/etiologia
Condrocalcinose/fisiopatologia
Feminino
Supressores da Gota/administração & dosagem
Seres Humanos
Osteoartrite do Joelho/cirurgia
Complicações Pós-Operatórias/diagnóstico
Complicações Pós-Operatórias/tratamento farmacológico
Complicações Pós-Operatórias/fisiopatologia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gout Suppressants); SML2Y3J35T (Colchicine); X69NU20D19 (Calcium Pyrophosphate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170607
[Lr] Data última revisão:
170607
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160729
[St] Status:MEDLINE
[do] DOI:10.1097/RHU.0000000000000384


  9 / 918 MEDLINE  
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[PMID]:27355536
[Au] Autor:Rosenthal AK; Ryan LM
[Ad] Endereço:From the Division of Rheumatology, Department of Medicine, Medical College of Wisconsin (A.K.R., L.M.R.), and the Department of Medicine, Zablocki Veterans Affairs Medical Center (A.K.R.) - both in Milwaukee.
[Ti] Título:Calcium Pyrophosphate Deposition Disease.
[So] Source:N Engl J Med;374(26):2575-84, 2016 Jun 30.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Condrocalcinose
[Mh] Termos MeSH secundário: Anti-Inflamatórios/uso terapêutico
Anti-Inflamatórios não Esteroides/uso terapêutico
Pirofosfato de Cálcio
Cartilagem/diagnóstico por imagem
Cartilagem/patologia
Condrocalcinose/diagnóstico
Condrocalcinose/tratamento farmacológico
Condrocalcinose/etiologia
Cristalização
Erros de Diagnóstico
Glucocorticoides/uso terapêutico
Seres Humanos
Injeções Intra-Arteriais
Metotrexato/uso terapêutico
Prevalência
Radiografia
Fatores de Risco
Terminologia como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Glucocorticoids); X69NU20D19 (Calcium Pyrophosphate); YL5FZ2Y5U1 (Methotrexate)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160630
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMra1511117


  10 / 918 MEDLINE  
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[PMID]:27237823
[Au] Autor:Kobayashi T; Miyakoshi N; Abe T; Abe E; Kikuchi K; Noguchi H; Konno N; Shimada Y
[Ad] Endereço:Department of Orthopedic Surgery, Akita Kousei Medical Center, 1-1-1 Iijima-Nishifukuro, Akita, 011-0948, Japan. takakoba825@hotmail.com.
[Ti] Título:Acute neck pain caused by pseudogout attack of calcified cervical yellow ligament: a case report.
[So] Source:J Med Case Rep;10(1):133, 2016 May 30.
[Is] ISSN:1752-1947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Calcification of the yellow ligament sometimes compresses the spinal cord and can induce myelopathy. Usually, the calcification does not induce acute neck pain. We report a case of a patient with acute neck pain caused by calcium pyrophosphate dihydrate in a calcified cervical yellow ligament. CASE PRESENTATION: A 70-year-old Japanese woman presented with acute neck pain. She had a moderately high fever (37.5 °C), and her neck pain was so severe that she could not move her neck in any direction. Computed tomography showed a high-density area between the C5 and C6 laminae suspicious for calcification of the yellow ligament. Magnetic resonance imaging showed intermediate-signal intensity on T1-weighted imaging and high-signal intensity on T2-weighted imaging surrounding a low-signal region on both T1- and T2-weighted imaging with cord compression. There was a turbid, yellow fluid collection in the yellow ligament at the time of operation. Histologically, calcium pyrophosphate dihydrate crystals were found in the fluid, and she was diagnosed as having a pseudogout attack of the yellow ligament. CONCLUSIONS: Pseudogout attack of the cervical yellow ligament is rare, but this clinical entity should be added to the differential diagnosis of acute neck pain, especially when calcification of the yellow ligament exists.
[Mh] Termos MeSH primário: Calcinose/diagnóstico por imagem
Pirofosfato de Cálcio
Condrocalcinose/diagnóstico por imagem
Ligamento Amarelo/diagnóstico por imagem
Cervicalgia/diagnóstico por imagem
Compressão da Medula Espinal/diagnóstico por imagem
[Mh] Termos MeSH secundário: Dor Aguda
Idoso
Calcinose/complicações
Calcinose/cirurgia
Vértebras Cervicais
Condrocalcinose/complicações
Condrocalcinose/cirurgia
Feminino
Seres Humanos
Ligamento Amarelo/cirurgia
Imagem por Ressonância Magnética
Cervicalgia/etiologia
Cervicalgia/cirurgia
Compressão da Medula Espinal/etiologia
Compressão da Medula Espinal/cirurgia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
X69NU20D19 (Calcium Pyrophosphate)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170116
[Lr] Data última revisão:
170116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160531
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-016-0928-1



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