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Pesquisa : D01.029.260.700.675.374.425 [Categoria DeCS]
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[PMID]:28338640
[Au] Autor:Gourni E; Henriksen G
[Ad] Endereço:Institute of Basic Medical Sciences, University of Oslo, Oslo 0372, Norway. eleni.gourni@medisin.uio.no.
[Ti] Título:Metal-Based PSMA Radioligands.
[So] Source:Molecules;22(4), 2017 Mar 24.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Prostate cancer is one of the most common malignancies for which great progress has been made in identifying appropriate molecular targets that would enable efficient in vivo targeting for imaging and therapy. The type II integral membrane protein, prostate specific membrane antigen (PSMA) is overexpressed on prostate cancer cells in proportion to the stage and grade of the tumor progression, especially in androgen-independent, advanced and metastatic disease, rendering it a promising diagnostic and/or therapeutic target. From the perspective of nuclear medicine, PSMA-based radioligands may significantly impact the management of patients who suffer from prostate cancer. For that purpose, chelating-based PSMA-specific ligands have been labeled with various diagnostic and/or therapeutic radiometals for single-photon-emission tomography (SPECT), positron-emission-tomography (PET), radionuclide targeted therapy as well as intraoperative applications. This review focuses on the development and further applications of metal-based PSMA radioligands.
[Mh] Termos MeSH primário: Metais/metabolismo
Antígeno Prostático Específico/metabolismo
Compostos Radiofarmacêuticos/metabolismo
[Mh] Termos MeSH secundário: Ligantes
Fosforamidas/metabolismo
Ureia/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Ligands); 0 (Metals); 0 (Phosphoramides); 0 (Radiopharmaceuticals); 8W8T17847W (Urea); EC 3.4.21.77 (Prostate-Specific Antigen)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE


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Mathias, Paulo Cézar de Freitas
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[PMID]:27765684
[Au] Autor:Ribeiro TA; Prates KV; Pavanello A; Malta A; Tófolo LP; Martins IP; Oliveira JC; Miranda RA; Gomes RM; Vieira E; Franco CC; Barella LF; Francisco FA; Alves VS; Silveira SD; Moreira VM; Fabricio GS; Palma-Rigo K; Sloboda DM; Mathias PC
[Ad] Endereço:Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá-5790, 87020-900 Maringá, PR, Brazil. Electronic address: tatianeribeiro2@hotmail.com.
[Ti] Título:Acephate exposure during a perinatal life program to type 2 diabetes.
[So] Source:Toxicology;372:12-21, 2016 Nov 30.
[Is] ISSN:1879-3185
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Acephate has been used extensively as an insecticide in agriculture. Its downstream sequelae are associated with hyperglycemia, lipid metabolism dysfunction, DNA damage, and cancer, which are rapidly growing epidemics and which lead to increased morbidity and mortality rates and soaring health-care costs. Developing interventions will require a comprehensive understanding of which excess insecticides during perinatal life can cause insulin resistance and type 2 diabetes. A Wistar rat animal model suggests that acephate exposure during pregnancy and lactation causes alterations in maternal glucose metabolism and programs the offspring to be susceptible to type 2 diabetes at adulthood. Therapeutic approaches based on preventive actions to food contaminated with insecticides during pregnancy and lactation could prevent new cases of type 2 diabetes.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/induzido quimicamente
Inseticidas/toxicidade
Compostos Organotiofosforados/toxicidade
Fosforamidas/toxicidade
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Diabetes Mellitus Tipo 2/patologia
Feminino
Seres Humanos
Lactação
Gravidez
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Insecticides); 0 (Organothiophosphorus Compounds); 0 (Phosphoramides); 3Y417O444D (acephate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161022
[St] Status:MEDLINE


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[PMID]:27638957
[Au] Autor:Miao J; Reisig DD; Li G; Wu Y
[Ad] Endereço:Institute of Plant Protection, Henan Academy of Agricultural Sciences, Zhengzhou 450002, P.R. China (miaojin1977@163.com) Department of Entomology, North Carolina State University, The Vernon James Research & Extension Center, 207 Research Station Road, Plymouth, NC 27962.
[Ti] Título:Sublethal Effects of Insecticide Exposure on Megacopta cribraria (Fabricius) Nymphs: Key Biological Traits and Acetylcholinesterase Activity.
[So] Source:J Insect Sci;16(1), 2016.
[Is] ISSN:1536-2442
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Megacopta cribraria F. (Hemiptera: Plataspidae), the kudzu bug, is an invasive insect pest of U.S. soybean. At present, insecticide application is the primary and most effective control option for M. cribraria In this study, the potential effects of sublethal and low-lethal concentrations (LC10 and LC40) of three common insecticides on key biological traits and acetylcholinesterase (AChE) activity of the treated nymphal stage of insect were assessed. The results show that the sublethal concentration of imidacloprid significantly reduced adult emergence rate of M. cribraria A low-lethal concentration of imidacloprid significantly increased nymphal development time, but significantly decreased adult emergence rate and adult longevity. Both sublethal and low-lethal concentrations of acephate caused an increase in nymphal development time and a reduction in adult emergence rate and adult longevity. Fecundity of females was significantly reduced only by exposure to low-lethal concentrations of acephate. Sublethal and low-lethal concentrations of bifenthrin increased nymphal development time, but significantly decreased adult emergence rate. In addition, we found that the AChE activity of M. cribraria was significantly increased only by LC40 imidacloprid, but strongly inhibited by acephate.
[Mh] Termos MeSH primário: Acetilcolinesterase/genética
Heterópteros/efeitos dos fármacos
Inseticidas/farmacologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Animais
Heterópteros/enzimologia
Heterópteros/crescimento & desenvolvimento
Imidazóis/farmacologia
Neonicotinoides
Nitrocompostos/farmacologia
Ninfa/efeitos dos fármacos
Ninfa/enzimologia
Ninfa/crescimento & desenvolvimento
Compostos Organotiofosforados/farmacologia
Fosforamidas/farmacologia
Piretrinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Imidazoles); 0 (Insecticides); 0 (Neonicotinoids); 0 (Nitro Compounds); 0 (Organothiophosphorus Compounds); 0 (Phosphoramides); 0 (Pyrethrins); 3BN7M937V8 (imidacloprid); 3Y417O444D (acephate); 6B66JED0KN (bifenthrin); EC 3.1.1.7 (Acetylcholinesterase)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160918
[St] Status:MEDLINE


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[PMID]:27574398
[Au] Autor:Coyne CP; Narayanan L
[Ad] Endereço:Department of Basic Sciences.
[Ti] Título:Dexamethasone-(C21-phosphoramide)-[anti-EGFR]: molecular design, synthetic organic chemistry reactions, and antineoplastic cytotoxic potency against pulmonary adenocarcinoma (A549).
[So] Source:Drug Des Devel Ther;10:2575-97, 2016.
[Is] ISSN:1177-8881
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Corticosteroids are effective in the management of a variety of disease states, such as several forms of neoplasia (leukemia and lymphoma), autoimmune conditions, and severe inflammatory responses. Molecular strategies that selectively "target" delivery of corticosteroids minimize or prevents large amounts of the pharmaceutical moiety from passively diffusing into normal healthy cell populations residing within tissues and organ systems. MATERIALS AND METHODS: The covalent immunopharmaceutical, dexamethasone-(C21-phosphoramide)-[anti-EGFR] was synthesized by reacting dexamethasone-21-monophosphate with a carbodiimide reagent to form a dexamethasone phosphate carbodiimide ester that was subsequently reacted with imidazole to create an amine-reactive dexamethasone-(C21-phosphorylimidazolide) intermediate. Monoclonal anti-EGFR immunoglobulin was combined with the amine-reactive dexamethasone-(C21-phosphorylimidazolide) intermediate, resulting in the synthesis of the covalent immunopharmaceutical, dexamethasone-(C21-phosphoramide)-[anti-EGFR]. Following spectrophotometric analysis and validation of retained epidermal growth factor receptor type 1 (EGFR)-binding avidity by cell-ELISA, the selective anti-neoplasic cytotoxic potency of dexamethasone-(C21-phosphoramide)-[anti-EGFR] was established by MTT-based vitality stain methodology using adherent monolayer populations of human pulmonary adenocarcinoma (A549) known to overexpress the tropic membrane receptors EGFR and insulin-like growth factor receptor type 1. RESULTS: The dexamethasone:IgG molar-incorporation-index for dexamethasone-(C21-phosphoramide)-[anti-EGFR] was 6.95:1 following exhaustive serial microfiltration. Cytotoxicity analysis: covalent bonding of dexamethasone to monoclonal anti-EGFR immunoglobulin did not significantly modify the ex vivo antineoplastic cytotoxicity of dexamethasone against pulmonary adenocarcinoma at and between the standardized dexamethasone equivalent concentrations of 10(-9) M and 10(-5) M. Rapid increases in antineoplastic cytotoxicity were observed at and between the dexamethasone equivalent concentrations of 10(-9) M and 10(-7) M where cancer cell death increased from 7.7% to a maximum of 64.9% (92.3%-35.1% residual survival), respectively, which closely paralleled values for "free" noncovalently bound dexamethasone. DISCUSSION: Organic chemistry reaction regimens were optimized to develop a multiphase synthesis regimen for dexamethasone-(C21-phosphoramide)-[anti-EGFR]. Attributes of dexamethasone-(C21-phosphoramide)-[anti-EGFR] include a high dexamethasone molar incorporation-index, lack of extraneous chemical group introduction, retained EGFR-binding avidity ("targeted" delivery properties), and potential to enhance long-term pharmaceutical moiety effectiveness.
[Mh] Termos MeSH primário: Adenocarcinoma/patologia
Antineoplásicos/farmacologia
Dexametasona/análogos & derivados
Desenho de Drogas
Neoplasias Pulmonares/patologia
Fosforamidas/farmacologia
[Mh] Termos MeSH secundário: Adenocarcinoma/tratamento farmacológico
Antineoplásicos/síntese química
Antineoplásicos/química
Morte Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Dexametasona/síntese química
Dexametasona/química
Dexametasona/farmacologia
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Neoplasias Pulmonares/tratamento farmacológico
Fosforamidas/síntese química
Fosforamidas/química
Relação Estrutura-Atividade
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Phosphoramides); 0 (dexamethasone-(C21-phosphoramide)-(anti-EGFR)); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160831
[St] Status:MEDLINE
[do] DOI:10.2147/DDDT.S102075


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[PMID]:27507601
[Au] Autor:Estévez J; Selva V; Benabent M; Mangas I; Sogorb MÁ; Vilanova E
[Ad] Endereço:University "Miguel Hernández", Institute of Bioengineering, Unit of Toxicology, Elche, Spain. Electronic address: jorge.estevez@umh.es.
[Ti] Título:Acetylcholine-hydrolyzing activities in soluble brain fraction: Characterization with reversible and irreversible inhibitors.
[So] Source:Chem Biol Interact;259(Pt B):374-381, 2016 Nov 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Some effects of organophosphorus compounds (OPs) esters cannot be explained through actions on currently recognized targets acetylcholinesterase or neuropathy target esterase (NTE). In soluble chicken brain fraction, three components (Eα, Eß and Eγ) of pheny lvalerate esterase activity (PVase) were kinetically discriminated and their relationship with acetylcholine-hydrolyzing activity (cholinesterase activity) were studied in previous works. In this work, four enzymatic components (CS1, CS2, CS3 and CS4) of cholinesterase activity have been discriminated in soluble fraction, according to their sensitivity to irreversible inhibitors mipafox, paraoxon, PMSF and iso-OMPA and to reversible inhibitors ethopropazine and BW284C51. Cholinesterase component CS1 can be related to the Eα component of PVase activity and identified as butyrylcholinesterase (BuChE). No association and similarities can be stablished among the other PVase component (Eß and Eγ) with the other cholinesterase components (CS2, CS3, CS4). The kinetic analysis has allowed us to stablish a method for discriminating the enzymatic component based on a simple test with two inhibitors. It can be used as biomarker in toxicological studies and for monitoring these cholinesterase components during isolation and molecular identification processes, which will allow OP toxicity to be understood by a multi-target approach.
[Mh] Termos MeSH primário: Acetilcolina/metabolismo
Acetilcolinesterase/metabolismo
Encéfalo/enzimologia
Inibidores da Colinesterase/farmacologia
[Mh] Termos MeSH secundário: Acetiltiocolina/metabolismo
Animais
Hidrolases de Éster Carboxílico/antagonistas & inibidores
Hidrolases de Éster Carboxílico/metabolismo
Galinhas
Hidrólise/efeitos dos fármacos
Fenotiazinas/farmacologia
Fosforamidas/farmacologia
Solubilidade
Frações Subcelulares/enzimologia
Fatores de Tempo
Compostos de Tosil/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholinesterase Inhibitors); 0 (Phenothiazines); 0 (Phosphoramides); 0 (Tosyl Compounds); 4468-05-7 (Acetylthiocholine); 455-16-3 (4-toluenesulfonyl fluoride); 7WI4P02YN1 (profenamine); EC 3.1.1.- (Carboxylic Ester Hydrolases); EC 3.1.1.- (neurotoxic esterase); EC 3.1.1.7 (Acetylcholinesterase); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160811
[St] Status:MEDLINE


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[PMID]:27498509
[Au] Autor:Ramya SL; Venkatesan T; Murthy KS; Jalali SK; Varghese A
[Ti] Título:Degradation of acephate by Enterobacter asburiae, Bacillus cereus and Pantoea agglomerans isolated from diamondback moth Plutella xylostella (L), a pest of cruciferous crops.
[So] Source:J Environ Biol;37(4):611-8, 2016 Jul.
[Is] ISSN:0254-8704
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Acephate-degrading bacterial isolates were isolated from the larval gut of diamondback moth Plutella xylostella, a notorious pest of cruciferous crops worldwide that has developed resistance to insecticides. Partial 16S rRNA gene sequencing identified the isolates as Bacillus cereus (PX-B.C.Or), Enterobacter asburiae (PXE), and Pantoae agglomerans (PX-Pt.ag.Jor). All isolates grew on minimal media (MM) in the presence of acephate at 100 and 200 ppm, with maximum growth at 200 ppm. LC-MS analyses of spent medium showed that E. asburiae degraded acephate to methamidophos and O, O-dimethyl phosporamidate and B. cereus O,S-dimethyl to phosphorothioate but P. agglomerans to an unnamed compound. All three isolates used acephate as a source of carbon and energy for growth; however, P. agglomerans used it also as source of sulphur. Strong evidence revealed that the bacterial communities present in the gut of diamondback moth might aid in acephate degradation and play a role in the development of insecticide resistance.
[Mh] Termos MeSH primário: Bacillus cereus/metabolismo
Enterobacter/metabolismo
Inseticidas/metabolismo
Mariposas/microbiologia
Compostos Organotiofosforados/metabolismo
Pantoea/metabolismo
Fosforamidas/metabolismo
[Mh] Termos MeSH secundário: Animais
Bacillus cereus/genética
Biodegradação Ambiental
Brassicaceae/crescimento & desenvolvimento
Produtos Agrícolas/crescimento & desenvolvimento
DNA Bacteriano/genética
DNA Bacteriano/metabolismo
Enterobacter/genética
Larva/crescimento & desenvolvimento
Larva/microbiologia
Dados de Sequência Molecular
Mariposas/crescimento & desenvolvimento
Pantoea/genética
Filogenia
RNA Ribossômico 16S/genética
RNA Ribossômico 16S/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Insecticides); 0 (Organothiophosphorus Compounds); 0 (Phosphoramides); 0 (RNA, Ribosomal, 16S); 3Y417O444D (acephate)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170203
[Lr] Data última revisão:
170203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160809
[St] Status:MEDLINE


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[PMID]:27372122
[Au] Autor:Lin W; Huang Z; Li X; Liu M; Cheng Y
[Ad] Endereço:The College of Environment and Resources, Fuzhou University, Fuzhou 350108, China. Electronic address: jasmine1113@hotmail.com.
[Ti] Título:Bio-remediation of acephate-Pb(II) compound contaminants by Bacillus subtilis FZUL-33.
[So] Source:J Environ Sci (China);45:94-9, 2016 Jul.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Removal of Pb(2+) and biodegradation of organophosphorus have been both widely investigated respectively. However, bio-remediation of both Pb(2+) and organophosphorus still remains largely unexplored. Bacillus subtilis FZUL-33, which was isolated from the sediment of a lake, possesses the capability for both biomineralization of Pb(2+) and biodegradation of acephate. In the present study, both Pb(2+) and acephate were simultaneously removed via biodegradation and biomineralization in aqueous solutions. Batch experiments were conducted to study the influence of pH, interaction time and Pb(2+) concentration on the process of removal of Pb(2+). At the temperature of 25°C, the maximum removal of Pb(2+) by B.subtilis FZUL-33 was 381.31±11.46mg/g under the conditions of pH5.5, initial Pb(2+) concentration of 1300mg/L, and contact time of 10min. Batch experiments were conducted to study the influence of acephate on removal of Pb(2+) and the influence of Pb(2+) on biodegradation of acephate by B.subtilis FZUL-33. In the mixed system of acephate-Pb(2+), the results show that biodegradation of acephate by B.subtilis FZUL-33 released PO4(3+), which promotes mineralization of Pb(2+). The process of biodegradation of acephate was affected slightly when the concentration of Pb(2+) was below 100mg/L. Based on the results, it can be inferred that the B.subtilis FZUL-33 plays a significant role in bio-remediation of organophosphorus-heavy metal compound contamination.
[Mh] Termos MeSH primário: Bacillus subtilis/metabolismo
Biodegradação Ambiental
Chumbo/metabolismo
Compostos Organotiofosforados/metabolismo
Fosforamidas/metabolismo
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organothiophosphorus Compounds); 0 (Phosphoramides); 0 (Water Pollutants, Chemical); 2P299V784P (Lead); 3Y417O444D (acephate)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170127
[Lr] Data última revisão:
170127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160704
[St] Status:MEDLINE


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[PMID]:27262970
[Au] Autor:Kumar R; Mandal K; Taggar GK; Singh R; Singh B
[Ad] Endereço:Pesticide Residue Analysis Laboratory, Department of Entomology, Punjab Agricultural University, Ludhiana, -141004, Punjab, India.
[Ti] Título:Bioefficacy and persistence of acephate in mungbean Vigna radiata (L.) Wilczek.
[So] Source:Environ Monit Assess;188(7):392, 2016 Jul.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The bioefficacy, persistence and metabolism of foliar application of acephate 75 SP at the respective recommended and double doses of 1500 and 3000 g a.i. ha(-1) were studied on kharif mungbean crop. Acephate gave a very effective control of the pod borer, Helicoverpa armigera (Hubner) at the tested doses on mungbean crop throughout the cropping season, besides recording lower percent pod damage and higher grain yield. The recommended dose of acephate also recorded higher net returns and thus indicating its superiority. Persistence of acephate in mungbean leaves and soil was studied following applications of acephate @ 1500 and 3000 g a.i. ha(-1) at 30 days after sowing. Residues of acephate in mungbean leaves and soil were estimated using gas liquid chromatograph (GLC) and confirmed on gas chromatograph-mass spectrometry (GC-MS). Half-life periods for acephate in mungbean leaves were observed to be 2.98 and 3.27 days at single and double the application rates, respectively. Residues of acephate dissipated below its limit of quantification (LOQ) of 0.05 mg kg(-1) after 20 and 25 days at single and double the application dosage, respectively. Similarly, half-life periods for acephate in mungbean soil were observed to be 1.86 and 1.94 days at single and double the application rates, respectively. Residues of acephate dissipated below its LOQ of 0.05 mg kg(-1) after 10 and 15 days at single and double the application dosage, respectively.
[Mh] Termos MeSH primário: Monitoramento Ambiental
Inseticidas/análise
Compostos Organotiofosforados/análise
Resíduos de Praguicidas/análise
Vigna/química
[Mh] Termos MeSH secundário: Cromatografia Gasosa
Cromatografia Gasosa-Espectrometria de Massas
Meia-Vida
Fosforamidas
Folhas de Planta/química
Solo/química
Poluentes do Solo/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Organothiophosphorus Compounds); 0 (Pesticide Residues); 0 (Phosphoramides); 0 (Soil); 0 (Soil Pollutants); 3Y417O444D (acephate)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160606
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-016-5348-6


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[PMID]:27258238
[Au] Autor:Dahlmann HA; McKinney AJ; Santos MP; Davis LO
[Ad] Endereço:Department of Chemistry and Biochemistry, Berry College, P.O. Box 495016, Mt. Berry, GA 30149, USA. hdahlmann@berry.edu.
[Ti] Título:Organocatalyzed Intramolecular Carbonyl-Ene Reactions.
[So] Source:Molecules;21(6), 2016 May 31.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:An organocatalyzed intramolecular carbonyl-ene reaction was developed to produce carbocyclic and heterocyclic 5- and 6-membered rings from a citronellal-derived trifluoroketone and a variety of aldehydes. A phosphoramide derivative was found to promote the cyclization of the trifluoroketone, whereas a less acidic phosphoric acid proved to be a superior catalyst for the aldehyde substrates.
[Mh] Termos MeSH primário: Aldeídos/química
Catálise
Cetonas/química
Fosforamidas/química
[Mh] Termos MeSH secundário: Ciclização
Estrutura Molecular
Monoterpenos/química
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aldehydes); 0 (Ketones); 0 (Monoterpenes); 0 (Phosphoramides); 13597-72-3 (phosphoramide); QB99VZZ7GZ (citronellal)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170412
[Lr] Data última revisão:
170412
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160604
[St] Status:MEDLINE


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Zanuncio, José C
Texto completo
[PMID]:27160634
[Au] Autor:Fernandes MES; Alves FM; Pereira RC; Aquino LA; Fernandes FL; Zanuncio JC
[Ad] Endereço:Universidade Federal de Viçosa, Campus Rio Paranaíba, Instituto de Ciências Agrárias, Rio Paranaíba, MG 38810-000, Brazil.
[Ti] Título:Lethal and sublethal effects of seven insecticides on three beneficial insects in laboratory assays and field trials.
[So] Source:Chemosphere;156:45-55, 2016 Aug.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lethal and sublethal effects of insecticides on target and non-target arthropods are a concern of pest management programs. Cycloneda sanguinea, Orius insidiosus and Chauliognathus flavipes are important biological control agents for aphids, whitefly, lepidopterus eggs, thrips and mites. All three test species were subjected to a toxicity study using the insecticides acephate, bifenthrin, chlorantraniliprole, chlorpyrifos, deltamethrin, imidacloprid, and thiamethoxam. Experiments were done in the lab and field. In the laboratory we evaluated the mortality and sublethal effects of the concentration that killed 20% of the population (LC20) on feeding, repellence and reproduction of the species tested. The lethal effects of these insecticides at the recommended doses was evaluated in the field. Concentration-response bioassays indicated chlorantraniliprole had the lowest toxicity, while chlorpyrifos and acephate were the most toxic. Test species exposed to filter paper surfaces treated with pyrethroids, neonicotinoids and organophosphates were repelled. On the other hand, test species were not repelled from surfaces treated with chlorantraniliprole. Chlorantraniliprole therefore seemed to be the least dangerous insecticide for these three beneficial arthropod test species.
[Mh] Termos MeSH primário: Coleópteros/efeitos dos fármacos
Heterópteros/efeitos dos fármacos
Inseticidas/toxicidade
[Mh] Termos MeSH secundário: Animais
Agentes de Controle Biológico
Clorpirifos/toxicidade
Coleópteros/fisiologia
Comportamento Alimentar/efeitos dos fármacos
Feminino
Heterópteros/fisiologia
Imidazóis/toxicidade
Masculino
Neonicotinoides
Nitrilos/toxicidade
Nitrocompostos/toxicidade
Compostos Organotiofosforados/toxicidade
Oxazinas/toxicidade
Fosforamidas/toxicidade
Piretrinas/toxicidade
Reprodução/efeitos dos fármacos
Tiazóis/toxicidade
ortoaminobenzoatos/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Control Agents); 0 (Imidazoles); 0 (Insecticides); 0 (Neonicotinoids); 0 (Nitriles); 0 (Nitro Compounds); 0 (Organothiophosphorus Compounds); 0 (Oxazines); 0 (Phosphoramides); 0 (Pyrethrins); 0 (Thiazoles); 0 (ortho-Aminobenzoates); 2JTS8R821G (decamethrin); 3BN7M937V8 (imidacloprid); 3Y417O444D (acephate); 622AK9DH9G (chlorantranilipole); 6B66JED0KN (bifenthrin); 747IC8B487 (thiamethoxam); JCS58I644W (Chlorpyrifos)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160511
[St] Status:MEDLINE



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