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Pesquisa : D01.045.250.875.600 [Categoria DeCS]
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[PMID]:29364603
[Au] Autor:Kashkak ES; Bel'kova NL; Danilova EV; Dagurova OP; Namsaraev BB; Gorlenko VM
[Ti] Título:Phylogenetic and Functional Prokaryotic Diversity in the Hoito-Gol Mesothermal Mineral Spring (Eastern Savan Mountains. Buryat Renuhlie).
[So] Source:Mikrobiologiia;85(5):555-567, 2016 Sep.
[Is] ISSN:0026-3656
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:High-throughput sequencing was used for comparative analysis of microbial communities of the water and mat from the Hoito-Gol mesothermal mineral sulfide spring (Eastern Sayan Mountains, Buryat Republic). Activity of microbial communities was determined. While both spring biotopes were dominated by members of three bacterial phyla, Proteobacteria, Bacteroidetes, and Firmicutes, they differed drastically in the composition of predominant phylotypes (at the genus level). In the water, the organisms wide spread in aquatic'environments were predominant, mostly aerobic chemoorganotrophs of the generaAcinetobacter, Pe- dobacter, and Flavobacterium. In the microbial mat,;the organisms actively involved in the sulfur cycle predominated, including sulfur-reducing bacteria Sulfurospirillum, sulfate-reducing deltaproteobacteria, sulfur- oxidizing chemoautotrophic bacteria, anoxygenic phototrophic bacteria of,the phyla Chloroflexi and Chloro- bi, as well as purple bacteria belonging to the Q-, P--, and y-Proteobacteria. Microbial mats of the spring exhibited higher phylogenetic diversity compared to high-temperature mats containing photosynthetic microorganisms.
[Mh] Termos MeSH primário: Água Subterrânea/microbiologia
Consórcios Microbianos/fisiologia
Águas Minerais/microbiologia
Filogenia
RNA Ribossômico 16S/genética
[Mh] Termos MeSH secundário: Bacteroidetes/classificação
Bacteroidetes/genética
Bacteroidetes/isolamento & purificação
Biodiversidade
Campylobacteraceae/classificação
Campylobacteraceae/genética
Campylobacteraceae/isolamento & purificação
Deltaproteobacteria/classificação
Deltaproteobacteria/genética
Deltaproteobacteria/isolamento & purificação
Ecossistema
Firmicutes/classificação
Firmicutes/genética
Firmicutes/isolamento & purificação
Metano/química
Metano/metabolismo
Proteobactérias/classificação
Proteobactérias/genética
Proteobactérias/isolamento & purificação
Estações do Ano
Sibéria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mineral Waters); 0 (RNA, Ribosomal, 16S); OP0UW79H66 (Methane)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE


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[PMID]:29311447
[Au] Autor:Kataoka Y; Watanabe T; Hayashi K; Ozawa R; Takizawa K; Akiyama H
[Ad] Endereço:National Institute of Health Sciences.
[Ti] Título:[Surveillance of Chromium(VI) Concentrations in Mineral Water Products].
[So] Source:Shokuhin Eiseigaku Zasshi;58(6):275-280, 2017.
[Is] ISSN:1882-1006
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:We developed and evaluated a method of quantifying chromium(VI) in mineral water (MW). After a performance evaluation, we performed a surveillance of chromium(VI) concentrations in 150 kinds of MW products purchased from markets in 2016. Recovery rates, as examined by using 150 spiked samples prepared from the purchased MW products, ranged from 93 to 107%. These results strongly suggest that the validated method is suitable for quantifying chromium(VI) in MW. Chromium(VI) was detected in 65 kinds of MW products; the detection rate was 43%. The minimum concentration of chromium(VI) was 0.0001 mg/L and the maximum was 0.0019 mg/L. The median value of chromium(VI) concentration was 0.0003 mg/L. In most of the products in which chromium(VI) was detected, the concentration ranged from 0.0001 to 0.0002 mg/L. No products were found with concentrations higher than the value (0.05 mg/L) set by the Food Sanitation Law as the specification for MW.
[Mh] Termos MeSH primário: Compostos de Cromo/análise
Águas Minerais/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Cromatografia por Troca Iônica/instrumentação
Cromatografia por Troca Iônica/métodos
Compostos de Cromo/isolamento & purificação
Legislação sobre Alimentos/normas
Águas Minerais/normas
Poluentes Químicos da Água/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chromium Compounds); 0 (Mineral Waters); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.3358/shokueishi.58.275


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[PMID]:29206009
[Au] Autor:Pinto Costa RM
[Ti] Título:Hydrotherapy and medical entrepreneurship: the "water spell" of Ricardo Jorge.
[So] Source:Dynamis;37(1):133-57, 2017.
[Is] ISSN:0211-9536
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:Between 1886 and 1893, the doctor and hygienist Ricardo Jorge was linked to a commercial and medical project on the waters of Gerês. Known for many centuries and used for therapeutic purposes, they were administered on an empirical basis. When new chemical analyses were first published, the empirical properties of these waters took on a new role in hydrotherapy based on their now proven mineral and medicinal qualities. The article discusses in detail Ricardo Jorge's business venture, framing it in the context of the economic collection and treatment potential of mineral waters and the revival of the phenomenon of hydrotherapy, legitimized by new developments in the chemical analysis of waters. The commercial failure to exploit the water resources highlights the difficulties of this project and the complexity of the professional practice of hydrological medicine, although it resulted in a strengthening of Ricardo's authority and prestige in the field of hydrotherapy.
[Mh] Termos MeSH primário: Contrato de Risco/história
Hidroterapia/história
Águas Minerais/história
[Mh] Termos MeSH secundário: História do Século XIX
Hidroterapia/economia
Hidroterapia/métodos
Águas Minerais/análise
Portugal
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mineral Waters)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:QIS
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


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[PMID]:29029618
[Au] Autor:Bajgai J; Fadriquela A; Ara J; Begum R; Ahmed MF; Kim CS; Kim SK; Shim KY; Lee KJ
[Ad] Endereço:Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju, Gangwon, 26426, Republic of Korea.
[Ti] Título:Balneotherapeutic effects of high mineral spring water on the atopic dermatitis-like inflammation in hairless mice via immunomodulation and redox balance.
[So] Source:BMC Complement Altern Med;17(1):481, 2017 Oct 13.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Atopic dermatitis (AD) is a chronic relapsing allergic inflammatory skin disease that currently affects millions of children and adults worldwide. Drugs used to treat these inflammatory diseases include anti-histamines, corticosteroids and calcineurin inhibitors but these drugs have their limitations such as adverse effects with their long-term usage. Thus, researcher's interest in several alternative and complementary therapies are continually growing and balneotherapy is one of these approaches. Therefore, we investigate the bathing effect of high concentration mineral spring water (HMW) on redox balance and immune modulation in 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis like inflammation in hairless mice. METHODS: We induced AD-like inflammation by application of DNCB on the dorsal skin of female skh-1 hairless mice. The mice were treated with 100% pure HMW (PHMW) and 10% diluted HMW (DHMW) through bathing once a day for 4 weeks. Tacrolimus ointment (0.1%) was used as positive control (PC) and only DNCB treatment as negative control (NeC) group. The severity of skin lesion inflammation was assessed through clinical scoring and observing scratching behavior. Levels of immunoglobulin E (IgE) and inflammatory cytokines in serum were detected by ELISA and multiplex bead array system, and the levels of oxidative stress-related biomarkers and antioxidant enzyme were also measured. RESULTS: We found that HMW significantly decreased the scratching behavior in PHMW and DHMW groups at the 2nd week and in PHMW group at 4th week compared to NeC group. Likewise, serum IgE level was significantly decreased in DHMW group as compared to NeC group. In line, the level of inflammatory cytokines in serum such as interleukin (IL)-1ß, IL-13 and tumor necrosis factor-α were significantly inhibited in PHMW and DHMW groups compared to NeC group. In parallel, total reactive oxygen species (ROS) of serum level was significantly decreased in PHMW treatment groups compared to NeC group. Consistently, serum malondialdehyde (MDA) level in PHMW group was lower than in NeC group. By contrast, glutathione peroxidase (GPx) activity was significantly enhanced in PHMW than NeC. CONCLUSION: Collectively, our study indicates a balneotherapeutic effect of HMW on DNCB-induced AD like inflammation in hairless mice via immunomodulation and redox balance.
[Mh] Termos MeSH primário: Balneologia
Dermatite Atópica/terapia
Águas Minerais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Dermatite Atópica/induzido quimicamente
Dermatite Atópica/patologia
Dinitroclorobenzeno/efeitos adversos
Modelos Animais de Doenças
Feminino
Imunomodulação
Camundongos
Camundongos Pelados
Oxirredução
Pele/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mineral Waters); GE3IBT7BMN (Dinitrochlorobenzene)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171015
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1985-8


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[PMID]:28771156
[Au] Autor:Karakaya MÇ; Dogru M; Karakaya N; Kuluöztürk F; Nalbantçilar MT
[Ad] Endereço:Selçuk University Engineering Faculty Geological Engineering Department, Konya 42079, Turkey E-mail: mcelik@selcuk.edu.tr.
[Ti] Título:Radioactivity and hydrochemical properties of certain thermal Turkish spa waters.
[So] Source:J Water Health;15(4):591-601, 2017 Aug.
[Is] ISSN:1477-8920
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The study aims to determine the radioactivity levels of thermal waters which have been used seasonally or permanently in spas for therapeutic intentions. Samples were collected from spas in different regions of Turkey. Some radionuclides ( K, Th, Ra, Cs), gross alpha (GA) and gross beta (GB) activities, and physical and some chemical parameters were measured. Gamma radiation measurements for Ra, Th and K radionuclides were performed by using a high purity germanium (HPGe) detector. The results of the gamma spectrometry ranged from 1.385 to 11.025 Bql for Ra,
[Mh] Termos MeSH primário: Águas Minerais/análise
Radioisótopos/análise
Poluentes Radioativos da Água/análise
[Mh] Termos MeSH secundário: Banhos
Monitoramento Ambiental
Monitoramento de Radiação
Espectrometria gama
Turquia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mineral Waters); 0 (Radioisotopes); 0 (Water Pollutants, Radioactive)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.2166/wh.2017.263


  6 / 2830 MEDLINE  
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[PMID]:28646834
[Au] Autor:Sadowska1 A; Swiderski F; Rakowska R; Waszkiewicz-Robak B; Zebrowska-Krasuska M; Dybkowska E
[Ad] Endereço:Warsaw University of Life Sciences (SGGW), Faculty of Human Nutrition and Consumer Sciences, Department of Functional Food, Ecological Food and Commodities, Warsaw, Poland
[Ti] Título:Beverage osmolality as a marker for maintaining appropriate body hydration.
[So] Source:Rocz Panstw Zakl Hig;68(2):167-173, 2017.
[Is] ISSN:0035-7715
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Background: Osmolalities can be useful markers for determining whether given beverages are suited for maintaining an adequate hydration of the body. Losing 2% of body water relative to body mass reduces the efficiency of body function when undertaking physical effort by around 20%. Deficiencies in water intakes approaching 5-8% of body mass, double the impairment to the body's physical and mental functioning, whereas at a level of 10% the body becomes incapable of performing any sort of physical effort. For such reasons the body's hydration status is vital to its functioning. Objectives: To asses osmolalities as measured in various types of commercially available mineral waters and non-alcoholic beverages containing different amounts of extracts. Materials and Methods: Test materials were commercially available mineral waters (of low, medium and high mineral content) along with juices, nectars and drinks that are isotonic, energising and those described as being 'light' and sparkling. Osmolality was measured by the 800CL Osmometer instrument from TridentMed whilst the RL-type refractometer was used for determining extract values. Results: Isotonic drinks were found to have the same osmotic pressures as bodily fluids at 275 ­ 295 mOsm/kg water. The osmotic pressure in mineral waters depended on the extent of mineralisation and ranged from 13 mOsm / kg water (low mineral content) to 119 mOsm/kg water (high mineral content). Low osmolalities were also found in 'light' drinks (from 29.3 to 34 mOsm/kg water). Juices, nectars, energising drinks and colas typically have high sugar contents and have high osmolalities ranging 492 ­ 784 mOsm / kg water. Statistical analysis demonstrated significant associations (p < 0.05) between osmolalities and extract content in beverages as well as between osmolalities and mineral content in mineral waters. Upon factor analysis, it was possible to group the tested drinks according to similar osmolalities and extract content. Conclusions: Osmolalities measured in beverages are a marker that permits drinks to be classified into groups according to their tonicity and their ability to ensure that the body is properly hydrated; this becoming vital in cases when the body requires rapid body fluid replenishment.
[Mh] Termos MeSH primário: Bebidas/análise
Ingestão de Líquidos
Águas Minerais/análise
[Mh] Termos MeSH secundário: Biomarcadores
Seres Humanos
Concentração Osmolar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Mineral Waters)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170626
[St] Status:MEDLINE


  7 / 2830 MEDLINE  
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[PMID]:28374734
[Au] Autor:Bekhterev VN; Kabina EA
[Ad] Endereço:Research Centre of Balneotherapy and Rehabilitation, the branch of the federal state budgetary institution 'North Caucasian Federal Research and Clinical Centre', Russian Federal Medico-Biological Agency, Sochi, Russia; Federal state budgetary educational institution of higher professional education 'Sochi State University', Sochi, Russia.
[Ti] Título:[The isolation of organic compounds from hydrosulfuric mineral waters with the use of the extractive freezing-out technique with centrifugation].
[Ti] Título:Vydelenie organicheskikh veshchestv iz serovodorodnykh mineral'nykh vod metodom ekstraktsionnogo vymorazhivaniya s tsentrifugirovaniem..
[So] Source:Vopr Kurortol Fizioter Lech Fiz Kult;94(1):56-61, 2017.
[Is] ISSN:0042-8787
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The mineral waters, enriched with organic substances find extensive application in balneotherapy. The fast and efficient methods for the identification and quantitative measurement of organic compounds (in the first place, organic acids) in such waters need to be developed for the estimation of their quality and biological activity. AIM: The objective of the present study was to elaborate a gas chromatographic method for the determination of monobasic carbonic acids in sulfide-containing mineral waters by means of extractive freezing-out in combination with the application of the centrifugal forces for the elucidation of the metrological characteristics of the compounds of interest. The secondary objective was to estimate the prospects for the application of the method of interest for determining the dissolved organic compounds in mineral waters. MATERIAL AND METHODS: The following carbonic acids were used for the purposes of the study: acetic acid (analytical grade), Russia; propionic grade (extra pure), Ferak, Germany; butyric acid (pure), Russia; valeric acid (pure), Russia; caproic acid (pure), Russia; oenanthic acid (pure), Russia; and caprylic acid (pure), Russia). Acetonitrile («O¼ grade), Russia, was used as the extracting agent. The LV-210 analytical balance (Russia) was used to prepare the model and standard solutions of the organic compounds and to determine their mass. The extracts and standard mixture were investigated by the gas chromatographic technique with the use of the Kristallyuks apparatus («Meta-Khrom¼, Russia) equipped with the flame ionization detector and the capillary column. Extractive freezing-out in the combination with centrifugation was performed with the laboratory installation for this purpose. RESULTS: Under the model conditions, a single extractive freezing-out procedure with the centrifugation of the sample made it possible to reach the 22-37-fold concentration of C2-C8 monobasic carbonic acids during their transfer from water into acetonitrile. The metrological parameters of the proposed procedure for gas-chromatographic determination of the aforementioned acids in hydrosulfuric mineral waters were estimated. The limit of detection of acetic and propionic acids has been 0,2 mg/l, that for butyric acid 0,1 mg/l, for valeric, caproic, oenanthic and caprylic acids 0,05 mg/l. We failed to identify C2-C8 carbonic acids in hydrosulfuric water from the 6T well of the field Matsesta fields. The investigation of the extracts obtained by the proposed extraction procedure with the use of the newly developed variant of high performance liquid chromatography (HPLC) with diode-matrix detection revealed the presence of various amounts of unknown organic substances. The UV-spectrum of one of those components was obtained which made it possible to conjecture its molecular structure. The procedure for the sample preparation and the following determination of organic acids in water is simple, carried out in a single stage, and does not impose special requirements to the qualification of the researcher. It allows to describe the newly developed technique as a rapid test method. Along with it, realization of extraction in the negative temperature mode reduces the risk of decomposition of the thermally unstable chemical compounds being extracted and reduces volatility of the organic solvents being used. The technology of the method does not demand a special laboratory glassware and expendables.
[Mh] Termos MeSH primário: Ácidos Carboxílicos/isolamento & purificação
Fracionamento Químico/métodos
Congelamento
Sulfeto de Hidrogênio
Águas Minerais/análise
[Mh] Termos MeSH secundário: Balneologia
Estâncias para Tratamento de Saúde
Águas Minerais/normas
Federação Russa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carboxylic Acids); 0 (Mineral Waters); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.17116/kurort201794156-61


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[PMID]:28374725
[Au] Autor:Apsheva EL; El'garov AA; Kalmykova MA; El'garov MA
[Ad] Endereço:Kh.M. Berbekov Kabardino-Balkarian State University, Nal'chik, Russia.
[Ti] Título:[The spa and health resort-based treatment of the women of various employments presenting with arterial hypertension].
[Ti] Título:Sanatornoe lechenie zhenshchin razlichnykh professii s arterial'noi gipertenziei..
[So] Source:Vopr Kurortol Fizioter Lech Fiz Kult;94(1):9-14, 2017.
[Is] ISSN:0042-8787
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:AIM: The objective of the present study was to evaluate the effectiveness of balneotherapy for the women of various employments presenting with arterial hypertension. MATERIAL AND METHODS: The study included 57 women with stage I (n=29) and II (n=28) hypertension. One study group was comprised of 28 female motor drivers including taxi-drivers (n=12), personal car drivers (n=7), and trolleybus drivers (n=9) at the mean age of 46,2±6,9 years suffering from occupational emotional stress (OES) and systematic psychoemotional tension (PET). Another group consisted of 29 female service system operators and included teachers (n=14), medical professionals (n=8), and social workers (n=7) at the mean age of 46.1±7.0 years whose activities was either associated with PET or involved hard emotional labour (HEL). The severity of the disease, and the age of the members of the two groups exposed to PET or HEL were not significantly different. Both groups were formed by means of random assignment. All the patients were subdivided into two groups: group 1 was comprised of 29 women and included 15 service system operators and 14 those exposed to HEL; the major therapeutic factor chosen for their treatment was taking thermal nitrogen mineral baths (36-37 degrees Celsius during 15 min., 8-10 sessions per treatment course). The patients of group 2 (n=28 including 14 service system operators and 14 those exposed to HEL) underwent treatment with the use of bromiodine mineral baths (36-37 degrees Celsius during 15 min., 8-10 sessions per treatment course). ECG, 24hr arterial blood pressure monitoring (ABPM), and psychophyisiological testing (PPT) were used alongside with the routine general clinical examination and laboratory studies to evaluate the outcome and overall effectiveness of balneotherapy. RESULTS: The clinical and instrumental characteristics of the participants in the study (health status, peripheral and coronary hemodynamics, etc.) gave evidence of the considerable improvement in the general health status of 89.6% and 87.7% of the women suffering from arterial hypertension following their treatment with the use of nitric and bromiodnine thermal baths, respectively. At the same time, the patients of group 1 exhibited the marked improvement in the condition of the fast response system while those of group 2 experienced either the deterioration of the occupationally significant functions and characteristics (in 48.3% cases) or did not show their dynamic whatever (in 51.1% cases). CONCLUSION: The present study has demonstrated the high effectiveness of balneotherapy for the women of various professional employments presenting with stage I and II arterial hypertension making use of bromiodine mineral bath therapy even though such treatment resulted in the deterioration of professional functions and qualities in 48.3% of the cases; in contrast, the nitrogen-thermal therapy improved the working capacity of the patients. Based on these observations, it is recommended that the psychophysiological testing should be practiced following balneotherapy before the women with arterial hypertension resume their occupational activities.
[Mh] Termos MeSH primário: Balneologia/métodos
Esgotamento Profissional/terapia
Estâncias para Tratamento de Saúde
Hipertensão/terapia
Águas Minerais
[Mh] Termos MeSH secundário: Pressão Sanguínea/fisiologia
Eletrocardiografia Ambulatorial
Feminino
Frequência Cardíaca/fisiologia
Seres Humanos
Hipertensão/diagnóstico
Meia-Idade
Federação Russa
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mineral Waters)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.17116/kurort20179419-14


  9 / 2830 MEDLINE  
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[PMID]:28260734
[Au] Autor:Kataoka Y; Watanabe T; Matsuda R; Hayashi T; Akiyama H; Teshima R
[Ad] Endereço:National Institute of Health Sciences.
[Ti] Título:Validation Study on a Method for Simultaneous Quantification of Elements in Mineral Water and Surveillance of Element Concentrations.
[So] Source:Shokuhin Eiseigaku Zasshi;58(1):59-64, 2017.
[Is] ISSN:1882-1006
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A validation study was performed on the Japanese official method to determine several elements (B, Cr, Mn, Cu, Zn, As, Se, Cd, Ba, Pb) in mineral water simultaneously using ICP-MS. The trueness, repeatability and reproducibility of the method were estimated to be in the ranges of 95-106, 0.2-1.4 and 0.4-4.2%, respectively. The values of every performance parameter fulfilled the requirements in the guidelines announced by the Ministry of Health, Labour, and Welfare of Japan, and the validity of the method was confirmed. The concentrations of the elements in mineral water products purchased from Japanese markets in 2013 and 2014 were surveyed using the method. All products met the specifications defined in the Japanese Food Sanitation Law. No clear relationship between the element concentrations and the survey year or the producing country was found.
[Mh] Termos MeSH primário: Análise de Alimentos/métodos
Espectrometria de Massas/métodos
Águas Minerais/análise
Oligoelementos/análise
[Mh] Termos MeSH secundário: Japão
Legislação sobre Alimentos/normas
Águas Minerais/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Mineral Waters); 0 (Trace Elements)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.3358/shokueishi.58.59


  10 / 2830 MEDLINE  
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[PMID]:28012395
[Au] Autor:Lee KS; Kwon YS; Kim S; Moon DS; Kim HJ; Nam KS
[Ad] Endereço:Department of Pharmacology and Intractable Disease Research Center, School of Medicine, Dongguk University, Gyeongju, Republic of Korea.
[Ti] Título:Regulatory mechanism of mineral-balanced deep sea water on hypocholesterolemic effects in HepG2 hepatic cells.
[So] Source:Biomed Pharmacother;86:405-413, 2017 Feb.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Several previous studies have shown the benefits of deep sea water (DSW) in lipid metabolism. However, the effects of DSW on cellular cholesterol accumulation and synthesis induced by high glucose or free fatty acid plus high glucose [4.5g/L] (FFA/glucose) have not been fully elucidated to date. Herein, we showed the effects of mineral-balanced DSW [magnesium (Mg):calcium (Ca)=3:1] (MB-DSW) on cholesterol metabolism induced by high glucose or FFA/glucose in HepG2 hepatic cells. Moreover, the effects of high ratio Mg DSW [Mg:Ca=40:1] (Mg40) were also investigated. MB-DSW and Mg40 prevented the increase of cellular total cholesterol content in high glucose- or FFA/glucose-treated HepG2 hepatic cells. Furthermore, the inhibition by MB-DSW was closely related to the down-regulation of 3-hydroxy-3-methylglutatryl-CoA reductase (HMGCR) expression and an increase in the AMP-activated protein kinase (AMPK) phosphorylation, leading to decreased cholesterol synthesis in both high glucose- and FFA/glucose-treated conditions. However, this effect was not seen in case of Mg40. In addition, both MB-DSW and Mg40 induced the low-density lipoprotein receptor (LDLR) and diminished the proprotein convertase subtilisin/kexin type 9 (PCSK9) transcriptions in high glucose-treated HepG2 hepatic cells. This result demonstrates that the hypocholesterolemic effects of MB-DSW and Mg40 are mediated with LDL-c clearance through increases of LDLR and its transcription factors, such as peroxisome proliferator-activated receptor-α (PPAR-α), sterol regulatory element-binding protein (SREBP)-1a, and SREBP-2, mRNA synthesis and suppression of PCSK9 transcription. Moreover, apolipoprotein (Apo) A1 transcription was enhanced by MB-DSW and Mg40 without decreasing the expression of Apo B in high glucose-treated HepG2 hepatic cells. However, ApoA1 protein expression was not changed. Taken together, the present investigation suggests that DSW may prevent the high glucose- or FFA/glucose-induced increase of cellular cholesterol levels by inducing LDLR and ApoA1 transcriptions and inhibiting PCSK9 mRNA expression in HepG2 hepatic cells. Additionally, the ratio of Mg in DSW is an important factor that determines whether HMGCR expression and/or AMPK phosphorylation participate in the hypocholesterolemic effects of DSW.
[Mh] Termos MeSH primário: Anticolesterolemiantes/farmacologia
Águas Minerais/administração & dosagem
Minerais/farmacologia
[Mh] Termos MeSH secundário: Proteínas Quinases Ativadas por AMP/metabolismo
Linhagem Celular Tumoral
Colesterol/metabolismo
Regulação para Baixo/efeitos dos fármacos
Glucose/metabolismo
Células Hep G2
Seres Humanos
Hidroximetilglutaril-CoA Redutases/metabolismo
Lipoproteínas LDL/metabolismo
Fosforilação/efeitos dos fármacos
Pró-Proteína Convertase 9/metabolismo
RNA Mensageiro/metabolismo
Receptores de LDL/metabolismo
Água do Mar
Fatores de Transcrição/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticholesteremic Agents); 0 (Lipoproteins, LDL); 0 (Mineral Waters); 0 (Minerals); 0 (RNA, Messenger); 0 (Receptors, LDL); 0 (Transcription Factors); 97C5T2UQ7J (Cholesterol); EC 1.1.1.- (HMGCR protein, human); EC 1.1.1.- (Hydroxymethylglutaryl CoA Reductases); EC 2.7.11.31 (AMP-Activated Protein Kinases); EC 3.4.21.- (Proprotein Convertase 9); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161225
[St] Status:MEDLINE



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