Base de dados : MEDLINE
Pesquisa : D01.056.025 [Categoria DeCS]
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[PMID]:29478664
[Au] Autor:Xue R; Donovan A; Zhang H; Ma Y; Adams C; Yang J; Hua B; Inniss E; Eichholz T; Shi H
[Ad] Endereço:Department of Chemistry and Environmental Research Center, Missouri University of Science and Technology, Rolla, MO 65409, USA; Center for Single Nanoparticle, Single Cell, and Single Molecule Monitoring (CS(3)M), Missouri University of Science and Technology, Rolla, MO 65409, USA. Electronic addres
[Ti] Título:Simultaneous removal of ammonia and N-nitrosamine precursors from high ammonia water by zeolite and powdered activated carbon.
[So] Source:J Environ Sci (China);64:82-91, 2018 Feb.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:When adding sufficient chlorine to achieve breakpoint chlorination to source water containing high concentration of ammonia during drinking water treatment, high concentrations of disinfection by-products (DBPs) may form. If N-nitrosamine precursors are present, highly toxic N-nitrosamines, primarily N-nitrosodimethylamine (NDMA), may also form. Removing their precursors before disinfection should be a more effective way to minimize these DBPs formation. In this study, zeolites and activated carbon were examined for ammonia and N-nitrosamine precursor removal when incorporated into drinking water treatment processes. The test results indicate that Mordenite zeolite can remove ammonia and five of seven N-nitrosamine precursors efficiently by single step adsorption test. The practical applicability was evaluated by simulation of typical drinking water treatment processes using six-gang stirring system. The Mordenite zeolite was applied at the steps of lime softening, alum coagulation, and alum coagulation with powdered activated carbon (PAC) sorption. While the lime softening process resulted in poor zeolite performance, alum coagulation did not impact ammonia and N-nitrosamine precursor removal. During alum coagulation, more than 67% ammonia and 70%-100% N-nitrosamine precursors were removed by Mordenite zeolite (except 3-(dimethylaminomethyl)indole (DMAI) and 4-dimethylaminoantipyrine (DMAP)). PAC effectively removed DMAI and DMAP when added during alum coagulation. A combination of the zeolite and PAC selected efficiently removed ammonia and all tested seven N-nitrosamine precursors (dimethylamine (DMA), ethylmethylamine (EMA), diethylamine (DEA), dipropylamine (DPA), trimethylamine (TMA), DMAP, and DMAI) during the alum coagulation process.
[Mh] Termos MeSH primário: Amônia/análise
Nitrosaminas/análise
Poluentes Químicos da Água/análise
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Adsorção
Compostos de Alúmen
Amônia/química
Carvão Vegetal/química
Dimetilnitrosamina
Desinfecção
Água Potável
Nitrosaminas/química
Poluentes Químicos da Água/química
Zeolitas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alum Compounds); 0 (Drinking Water); 0 (Nitrosamines); 0 (Water Pollutants, Chemical); 1318-02-1 (Zeolites); 16291-96-6 (Charcoal); 34S289N54E (aluminum sulfate); 7664-41-7 (Ammonia); M43H21IO8R (Dimethylnitrosamine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE


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[PMID]:27774794
[Au] Autor:Seay JS; Mandigo M; Kish J; Menard J; Marsh S; Kobetz E
[Ad] Endereço:a Miller School of Medicine , University of Miami , Miami , FL , USA.
[Ti] Título:Intravaginal practices are associated with greater odds of high-risk HPV infection in Haitian women.
[So] Source:Ethn Health;22(3):257-265, 2017 Jun.
[Is] ISSN:1465-3419
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Haitian women have the highest incidence of cervical cancer within the Western hemisphere. Intravaginal hygiene practices have been linked with human papilloma virus (HPV) infection and cervical dysplasia. These practices, known as 'twalet deba' in Haitian Creole, are common among Haitian women and are performed with various natural and synthetic agents. As part of a community-based participatory research initiative aimed at reducing cervical cancer disparities in rural Haiti, we explored the use of intravaginal agents and their associations with high-risk HPV infection. DESIGN: Community Health Workers recruited 416 women for cervical self-sampling from two neighborhoods within Thomonde, Haiti. Participants were interviewed regarding intravaginal hygiene practices and completed a cervical self-sampling procedure. Cervical samples were analyzed for the presence of high-risk HPV infection. Associations between each intravaginal agent and high-risk HPV infection were examined via univariate logistic regression analyses, as well as via multivariate analyses controlling for sociodemographic factors and concurrent agent use. RESULTS: Nearly all women (97.1%) performed twalet deba, using a variety of herbal and commercially produced intravaginal agents. Approximately 11% of the participants tested positive for high-risk HPV. Pigeon pea and lime juice were the only agents found to be associated with high-risk HPV in the univariate analyses, with women who used these agents being approximately twice as likely to have high-risk HPV as those who did not. Only pigeon pea remained significantly associated with high-risk HPV after controlling for sociodemographic factors and concurrent agent use. CONCLUSION: Two agents, pigeon pea and lime juice, may contribute to risk for HPV infection in this population. Results suggest that in addition to cervical cancer screening interventions, future preventive initiatives should focus on minimizing risk by advocating for the use of less-toxic twalet deba alternatives.
[Mh] Termos MeSH primário: Conhecimentos, Atitudes e Prática em Saúde/etnologia
Higiene
Infecções por Papillomavirus/etnologia
Ducha Vaginal/efeitos adversos
[Mh] Termos MeSH secundário: Administração Intravaginal
Adulto
Compostos de Alúmen/administração & dosagem
Cajanus
Citrus aurantiifolia
Pesquisa Participativa Baseada na Comunidade
Feminino
Sucos de Frutas e Vegetais
Haiti/epidemiologia
Seres Humanos
Infecções por Papillomavirus/epidemiologia
Infecções por Papillomavirus/virologia
Preparações de Plantas/administração & dosagem
Permanganato de Potássio/administração & dosagem
Fatores de Risco
Sabões/administração & dosagem
Ducha Vaginal/métodos
Saúde da Mulher/etnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alum Compounds); 0 (Plant Preparations); 0 (Soaps); 00OT1QX5U4 (Potassium Permanganate); 34S289N54E (aluminum sulfate)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1080/13557858.2016.1246423


  3 / 1515 MEDLINE  
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[PMID]:28856818
[Au] Autor:Yang T; Zhou YH; Zhu SZ; Pan H; Huang YB
[Ad] Endereço:College of Chemical Engineering, Nanjing Forestry University, Longpan Road 159#, Nanjing, P.R: China.
[Ti] Título:Insight into Aluminum Sulfate-Catalyzed Xylan Conversion into Furfural in a γ-Valerolactone/Water Biphasic Solvent under Microwave Conditions.
[So] Source:ChemSusChem;10(20):4066-4079, 2017 Oct 23.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A simple and efficient biphasic system with an earth-abundant metal salt catalyst was used to produce furfural from xylan with a high yield of up to 87.8 % under microwave conditions. Strikingly, the metal salt Al (SO ) exhibited excellent catalytic activity for xylan conversion, owing to a combination of Lewis and Brønsted acidity and its ability to promote good phase separation. The critical role of the SO anion was first analyzed, which resulted in the aforementioned characteristics when combined with the Al cation. The mixed solvent system with γ-valerolactone (GVL) as the organic phase provided the highest furfural yield, resulting from its good dielectric properties and dissolving capacity, which facilitated the absorption of microwave energy and promoted mass transfer. Mechanistic studies suggested that the xylan-to-furfural conversion proceeded mainly through a hydrolysis-isomerization-dehydration pathway and the hexa-coordinated Lewis acidic [Al(OH) (aq)] species were the active sites for xylose-xylulose isomerization. Detailed kinetic studies of the subreaction for the xylan conversion revealed that GVL regulates the reaction rates and pathways by promoting the rates of the key steps involved for furfural production and suppressing the side reactions for humin production. Finally, the Al (SO ) catalyst was used for the production of furfural from several lignocellulosic feedstocks, revealing its great potential for other biomass conversions.
[Mh] Termos MeSH primário: Compostos de Alúmen/química
Lactonas/química
Micro-Ondas
Solventes/química
Água/química
Xilanos/química
[Mh] Termos MeSH secundário: Catálise
Cinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alum Compounds); 0 (Lactones); 0 (Solvents); 0 (Xylans); 059QF0KO0R (Water); 34S289N54E (aluminum sulfate); O7056XK37X (gamma-valerolactone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201701290


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[PMID]:28787755
[Au] Autor:Xie S; Guo C; Chi Z; Huang B; Wu Y; Wang D; Xia D
[Ad] Endereço:Department of Toxicology, School of Public Health, Zhejiang University, Hangzhou, China.
[Ti] Título:A rapid administration of GW4064 inhibits the NLRP3 inflammasome activation independent of farnesoid X receptor agonism.
[So] Source:FEBS Lett;591(18):2836-2847, 2017 Sep.
[Is] ISSN:1873-3468
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:GW4064 is a small molecule known to be an agonist of the nuclear farnesoid X receptor (FXR). We found that GW4064 inhibits the NLR family CARD domain containing 3 (NLRP3) inflammasome activation in an FXR-independent manner as evidenced by its similar inhibitory effect on NLRP3 inflammasome activation in FXR-deficient macrophages. Interestingly, GW4064 decreases the nigericin-induced oligomerization and ubiquitination of ASC which is critical for the NLRP3 inflammasome activation. In vivo results indicate that GW4064 could partially rescue the symptoms of NLRP3-dependent inflammatory disease models. These results not only necessitate cautious interpretation of the biological function of GW4064 as an FXR agonist, but also provide a potential therapeutic approach using GW4064 in the treatment of NLRP3-related diseases.
[Mh] Termos MeSH primário: Inflamassomos/efeitos dos fármacos
Inflamassomos/metabolismo
Isoxazóis/farmacologia
Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo
Receptores Citoplasmáticos e Nucleares/metabolismo
[Mh] Termos MeSH secundário: Compostos de Alúmen/toxicidade
Animais
Proteínas Reguladoras de Apoptose/genética
Proteínas Reguladoras de Apoptose/metabolismo
Proteínas Adaptadoras de Sinalização CARD
Células Cultivadas
Ensaio de Imunoadsorção Enzimática
Seres Humanos
Leucócitos Mononucleares/efeitos dos fármacos
Leucócitos Mononucleares/metabolismo
Macrófagos/efeitos dos fármacos
Macrófagos/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Proteína 3 que Contém Domínio de Pirina da Família NLR/genética
Nigericina/farmacologia
Peritonite/induzido quimicamente
Multimerização Proteica/efeitos dos fármacos
Multimerização Proteica/genética
Receptores Citoplasmáticos e Nucleares/genética
Sepse/metabolismo
Ubiquitinação/efeitos dos fármacos
Ubiquitinação/genética
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Alum Compounds); 0 (Apoptosis Regulatory Proteins); 0 (CARD Signaling Adaptor Proteins); 0 (Inflammasomes); 0 (Isoxazoles); 0 (NLR Family, Pyrin Domain-Containing 3 Protein); 0 (Pycard protein, mouse); 0 (Receptors, Cytoplasmic and Nuclear); 0 (farnesoid X-activated receptor); 34S289N54E (aluminum sulfate); RRU6GY95IS (Nigericin); SR225WUZ0H (GW 4064)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1002/1873-3468.12782


  5 / 1515 MEDLINE  
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[PMID]:28762144
[Au] Autor:Kluczka J; Zolotajkin M; Ciba J; Staron M
[Ad] Endereço:Department of Inorganic Chemistry, Analytical Chemistry and Electrochemistry, Faculty of Chemistry, Silesian University of Technology, B. Krzywoustego 6 Street, 44-100, Gliwice, Poland. joanna.kluczka@polsl.pl.
[Ti] Título:Assessment of aluminum bioavailability in alum sludge for agricultural utilization.
[So] Source:Environ Monit Assess;189(8):422, 2017 Aug.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Inorganic aluminum ions, [Al(H O) ] , [Al(OH)(H O) ] , and [Al(OH) (H O) ] , are toxic to a number of crops. The aim of this study was to estimate the danger of soil contamination of bioavailable aluminum and heavy metals forms because of alum sludge which was a by-product of water, and wastewater treatment technology using aluminum coagulant is introduced into the soil. Aluminum and selected heavy metal fractionation was carried out in the post-coagulation sludge collected at a water treatment plant (where aluminum was used as a coagulant), fermented sewage sludge at a municipal wastewater treatment plant (which did not apply aluminum coagulant), and soil from water treatment plant as well as the mixtures of sludge and soil. It has been found that post-coagulation sludge used as natural fertilizer is a secondary source of bioavailable aluminum, especially when aluminum coagulants are used during water and wastewater treatment. The evaluation of applicability of the sludge to very weak acidic and acidic agricultural soils was carried out. The authors shall debate the question whether, in this case, the Regulation of EU and Polish Government on sewage sludge should also take the bioavailable aluminum into account and add to the list of the elements whose allowable contents are limited.
[Mh] Termos MeSH primário: Agricultura
Alumínio/análise
Monitoramento Ambiental
Fertilizantes
[Mh] Termos MeSH secundário: Ácidos
Compostos de Alúmen
Produtos Agrícolas
Metais Pesados/análise
Esgotos
Solo
Eliminação de Resíduos Líquidos/métodos
Águas Residuais
Purificação da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acids); 0 (Alum Compounds); 0 (Fertilizers); 0 (Metals, Heavy); 0 (Sewage); 0 (Soil); 0 (Waste Water); 34S289N54E (aluminum sulfate); CPD4NFA903 (Aluminum)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-6133-x


  6 / 1515 MEDLINE  
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[PMID]:28719287
[Au] Autor:Schmidt AC; Lin L; Martinez LJ; Ruck RC; Eckels KH; Collard A; De La Barrera R; Paolino KM; Toussaint JF; Lepine E; Innis BL; Jarman RG; Thomas SJ
[Ad] Endereço:GSK Vaccines, Rixensart, Belgium.
[Ti] Título:Phase 1 Randomized Study of a Tetravalent Dengue Purified Inactivated Vaccine in Healthy Adults in the United States.
[So] Source:Am J Trop Med Hyg;96(6):1325-1337, 2017 Jun.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AbstractThe safety and immunogenicity of four formulations of an investigational tetravalent dengue purified inactivated vaccine (DPIV), formulated at 1 or 4 µg with aluminum hydroxide (alum) or at 1 µg with an adjuvant system (AS01 or AS03 ), were evaluated in a first-time-in-human, placebo-controlled, randomized, observer-blind, phase 1 trial in the continental United States. Two doses of vaccine or placebo were administered intramuscularly 4 weeks apart to 100 healthy adults 18-39 years of age, randomized 1:1:1:1:1 to receive one of four DPIV formulations or saline placebo. The response to a third dose was evaluated in a subset of nine participants remote from primary vaccination. Humoral immunogenicity was assessed using a 50% microneutralization assay. All DPIV formulations were well tolerated. No vaccine-related serious adverse events were observed through 12 months after the second vaccine dose. In all DPIV groups, geometric mean antibody titers peaked at Day 56, waned through 6 months after the second vaccine dose, and then stabilized. In the nine subjects where boosting was evaluated, a strong anamnestic response was observed. These results support continuation of the clinical development of this dengue vaccine candidate (clinicaltrials.gov: NCT01666652).
[Mh] Termos MeSH primário: Vacinas contra Dengue/uso terapêutico
Dengue/prevenção & controle
[Mh] Termos MeSH secundário: Adjuvantes Imunológicos/química
Adolescente
Adulto
Compostos de Alúmen/química
Anticorpos Antivirais/sangue
Dengue/imunologia
Vacinas contra Dengue/administração & dosagem
Vírus da Dengue/isolamento & purificação
Relação Dose-Resposta a Droga
Feminino
Seres Humanos
Masculino
Método Simples-Cego
Estados Unidos
Vacinação
Vacinas de Produtos Inativados/administração & dosagem
Vacinas de Produtos Inativados/uso terapêutico
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE I; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Alum Compounds); 0 (Antibodies, Viral); 0 (Dengue Vaccines); 0 (Vaccines, Inactivated); 34S289N54E (aluminum sulfate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0634


  7 / 1515 MEDLINE  
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[PMID]:28573247
[Au] Autor:Shahriari R; Salari S; Shahriari S
[Ad] Endereço:Department of Pathobiology, Faculty of Veterinary Medicine, University of Zabol, P.O. Box 98615-538, Zabol, 9861335856 Iran.
[Ti] Título: STUDY OF CONCENTRATION-EFFECT AND TIME-COURSE PATTERN OF WHITE ALUM ON O157:H7 GROWTH.
[So] Source:Afr J Tradit Complement Altern Med;14(2):311-318, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Nowadays, the demand for antibacterial fabrics has increased. White alum is used for oral aphthous ulcers treatment in traditional medicine of Sistan city, Sistan and Baluchistan Province, Iran, and also as a flocculent for water purification. This study is aimed to evaluate the effect of concentration and time on antibacterial activity of white alum on O157:H7. MATERIALS AND METHODS: 0.25, 0.5, 1 and 2% concentrations of white alum were added to 10 CFU of O157:H7. Optical Density was recorded for 4 hours. Data obtained were analyzed using Repeated Measure and One-way ANOVA by SPSS. RESULTS: Results revealed the effectiveness of white alum in the growth of the tested bacterium. The white alum was found to be potent against O157:H7 at a concentration above 1% (p<0.05). Also, its effect is dose and time dependent, as well as other disinfectants. CONCLUSION: A wide variety of natural products has been under scrutiny for their clinical potential, both in terms of prevention and treatment. Strong antibacterial activity of white alum compared with control was shown against tested bacterium. In conclusion, white alum can be used as an inhibitor of bacterial growth, especially for O157:H7.
[Mh] Termos MeSH primário: Compostos de Alúmen/farmacologia
Produtos Biológicos/farmacologia
Escherichia coli O157/efeitos dos fármacos
Minerais/farmacologia
[Mh] Termos MeSH secundário: Escherichia coli O157/crescimento & desenvolvimento
Irã (Geográfico)
Estomatite Aftosa/tratamento farmacológico
Purificação da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alum Compounds); 0 (Biological Products); 0 (Minerals); 34S289N54E (aluminum sulfate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i2.32


  8 / 1515 MEDLINE  
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[PMID]:28543600
[Au] Autor:Costoya L; Marzoa J; Ferreirós C; Criado MT
[Ad] Endereço:Departamento de Microbioloxía e Parasitoloxía, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
[Ti] Título:Liposomes or traditional adjuvants: induction of bactericidal activity by the macrophage infectivity potentiator protein (Mip) of Neisseria meningitidis.
[So] Source:APMIS;125(8):725-731, 2017 Aug.
[Is] ISSN:1600-0463
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Currently, one of the main approaches to achieve a vaccine for serogroup B Neisseria meningitidis is based on outer membrane proteins with low antigenic variability among strains. Since these proteins tend to be minor components of the outer membrane, recombinant production is required to obtain them in sufficient amounts for evaluation and development of vaccines. In this study, we analysed the ability of recombinant macrophage infectivity potentiator (rMip) protein to induce protective bactericidal activity in mice. The rMip protein was cloned from N. meningitidis strain H44/76 and was used to immunise mice, and the sera obtained were tested against the homologous and several heterologous N. meningitidis strains. The sera were obtained using the rMip alone, with adjuvant Al(OH) , or after inclusion into liposomes. Bactericidal activity was variable depending on the strain, although high titres were seen against strains H44/76 and NmP27. Liposomes enhanced fourfold the reactivity against the homologous strain. The results presented suggest that the rMip protein should be considered a promising candidate for the improvement of future protein-based vaccines.
[Mh] Termos MeSH primário: Adjuvantes Imunológicos/administração & dosagem
Antígenos de Bactérias/imunologia
Proteínas de Bactérias/imunologia
Vacinas Bacterianas/imunologia
Atividade Bactericida do Sangue
Lipossomos/administração & dosagem
Neisseria meningitidis Sorogrupo B/imunologia
[Mh] Termos MeSH secundário: Compostos de Alúmen/administração & dosagem
Animais
Antígenos de Bactérias/genética
Proteínas de Bactérias/genética
Vacinas Bacterianas/administração & dosagem
Vacinas Bacterianas/genética
Vacinas Bacterianas/isolamento & purificação
Camundongos Endogâmicos CBA
Viabilidade Microbiana
Neisseria meningitidis Sorogrupo B/genética
Vacinas Sintéticas/administração & dosagem
Vacinas Sintéticas/genética
Vacinas Sintéticas/imunologia
Vacinas Sintéticas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Alum Compounds); 0 (Antigens, Bacterial); 0 (Bacterial Proteins); 0 (Bacterial Vaccines); 0 (Liposomes); 0 (Vaccines, Synthetic); 34S289N54E (aluminum sulfate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12709


  9 / 1515 MEDLINE  
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[PMID]:28531557
[Au] Autor:Abusallout I; Hua G
[Ad] Endereço:Department of Civil and Environmental Engineering, South Dakota State University, Brookings, SD, 57007, USA.
[Ti] Título:Characterization of dissolved organic carbon leached from a woodchip bioreactor.
[So] Source:Chemosphere;183:36-43, 2017 Sep.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Woodchip bioreactors are increasingly being applied to remove nitrate from agricultural subsurface drainage. However, dissolved organic carbon (DOC) released from woodchips may negatively affect the aquatic ecosystems and drinking water supplies. The objective of this study was to evaluate the leaching characteristics, disinfection byproduct (DBP) formation potentials, and treatability of DOC derived from a laboratory woodchip bioreactor. Initial flush of woodchips resulted in the release of high organic content from woodchips. The DOC concentration in the bioreactor effluent decreased rapidly from 71.8 to 20.7 mg/L during the first week of operation, and then gradually decreased to 3.0 mg/L after 240 days of operation under a hydraulic retention time of 24 h. A recycled steel chip filter removed an average of 44.2% of the DOC in the bioreactor effluent. Hydrophobic carbons and organic compounds with molecular weight of 10-100 KDa were the most abundant organic fractions in the DOC released from woodchips. These two DOC fractions were also the most important precursors to the formation of total organic halogen (TOX) during chlorination and chloramination. The TOX yields of woodchip DOC were similar to those of Suwannee River Fulvic Acid, suggesting that organic compounds released from woodchips have great potentials for DBP formation. Alum and polyaluminium chloride were more effective at removing woodchip DOC than ferric chloride during coagulation. Drinking water treatment plants may need to adjust coagulant types and doses in order to remove woodchip DOC in the source water to reduce the DBP formation potential.
[Mh] Termos MeSH primário: Reatores Biológicos
Drenagem Sanitária/métodos
Hidrocarbonetos/análise
Poluentes Químicos da Água/análise
Purificação da Água/métodos
Madeira/química
[Mh] Termos MeSH secundário: Compostos de Alúmen/química
Desinfecção
Ecossistema
Filtração
Floculação
Halogenação
Hidrocarbonetos/química
Aço/química
Poluentes Químicos da Água/química
Abastecimento de Água/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alum Compounds); 0 (Hydrocarbons); 0 (Water Pollutants, Chemical); 12597-69-2 (Steel); 34S289N54E (aluminum sulfate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE


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[PMID]:28480759
[Au] Autor:Ludvigsson J
[Ad] Endereço:a Divsion of Pediatrics, Department of Clinical and Experimental Medicine , Linköping University , Linköping , Sweden.
[Ti] Título:GAD65: a prospective vaccine for treating Type 1 diabetes?
[So] Source:Expert Opin Biol Ther;17(8):1033-1043, 2017 Aug.
[Is] ISSN:1744-7682
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: In spite of modern techniques, the burden for patients with type 1 diabetes (T1D) will not disappear and T1D remains a life-threatening disease causing severe complications and increased mortality. We have to learn how to preserve residual insulin secretion or even increase beta cell regeneration. This would give a milder disease, simpler treatment and perhaps even cure. Thus, there are good reasons to try therapies that may preserve beta cell function. Areas covered: In this review the author reviews the literature and registered ongoing trials using GAD-alum put in relation to the high number of published different immune interventions. Expert opinion: GAD-alum treatment is safe, tolerable and easy for the patients and healthcare. It seems probable that treatment with GAD65-alum 20 µg sc can preserve residual beta cell function in T1D, but efficacy needs to be improved. This may be achieved by the use of combination therapies and new approaches for administration.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 1/prevenção & controle
Glutamato Descarboxilase/imunologia
[Mh] Termos MeSH secundário: Imunidade Adaptativa
Compostos de Alúmen/química
Ensaios Clínicos como Assunto
Diabetes Mellitus Tipo 1/imunologia
Glutamato Descarboxilase/química
Seres Humanos
Insulina/metabolismo
Insulina/secreção
Células Secretoras de Insulina/imunologia
Células Secretoras de Insulina/metabolismo
Vacinação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alum Compounds); 0 (Insulin); 34S289N54E (aluminum sulfate); EC 4.1.1.15 (Glutamate Decarboxylase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.1080/14712598.2017.1328495



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