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[PMID]:29175405
[Au] Autor:Yang F; Xie S; Liu J; Wei C; Zhang H; Chen T; Zhang J
[Ad] Endereço:Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, China; Key Laboratory of Land Surface Pattern and Simulation, Chinese Academy of Sciences, Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
[Ti] Título:Arsenic concentrations and speciation in wild birds from an abandoned realgar mine in China.
[So] Source:Chemosphere;193:777-784, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Birds are at a higher level in the food chain; however, the potential bioaccumulation and biotransformation of arsenic (As) in birds in As mines has rarely been studied. In this study, four passerine bird species (tree sparrow [Passer montanus], light-vented bulbul [Pycnonotus sinensis], Garrulax canorus [Leucodioptron canorus], and magpie [Pica pica]) were collected from an abandoned As mine in China. The highest recorded As concentrations were 4.95 mg/kg and 51.65 mg/kg in muscles and feathers, respectively. Detection using high-performance liquid chromatography inductively coupled plasma mass spectrometry (HPLC-ICP-MS) revealed six As species, including arsenite (As(III)), arsenate (As(V)), dimethylarsinic acid (DMA), monomethylarsonic acid (MMA), arsenobetaine (AsB) and arsenocholine (AsC), with the former three species as the dominant (>92%) and the latter three as the minor As species (<6.17%). Further analysis of the selected bird samples using the X-ray absorption near edge structure (XANES) technique revealed the existence of As(III)-tris-glutathione (As(III)-GSH), which can be regarded as equivalent to the non-extractable and unidentified As form in the HPLC-ICP-MS data. Both methods revealed similar patterns of As species in the birds from the As mine, with muscles containing mainly inorganic As and DMA and feathers containing mainly inorganic As. The results of this study contribute to the knowledge regarding As accumulation and speciation in terrestrial organisms.
[Mh] Termos MeSH primário: Arsênico/análise
Arsenicais/análise
Aves
Mineração
[Mh] Termos MeSH secundário: Animais
Arseniatos
Arsênico/química
Arsenitos
Ácido Cacodílico/análise
China
Cromatografia Líquida de Alta Pressão/métodos
Plumas/química
Espectrometria de Massas/métodos
Músculo Esquelético/química
Passeriformes
Sulfetos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenates); 0 (Arsenicals); 0 (Arsenites); 0 (Sulfides); 39895-81-3 (arsenocholine); 56320-22-0 (arsenic disulfide); AJ2HL7EU8K (Cacodylic Acid); J37VJ5709S (monomethylarsonic acid); N5509X556J (arsenite); N712M78A8G (Arsenic); N7CIZ75ZPN (arsenic acid); UWC1LS4V3I (arsenobetaine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:29264911
[Au] Autor:Mania M; Rebeniak M; Szynal T; Starska K; Wojciechowska-Mazurek M; Postupolski J
[Ad] Endereço:National Institute of Public Health-National Institute of Hygiene, Department of Food Safety, Warsaw, Poland
[Ti] Título:Exposure assessment of the population in Poland to the toxic effects of arsenic compounds present in rice and rice based products
[So] Source:Rocz Panstw Zakl Hig;68(4):339-346, 2017.
[Is] ISSN:0035-7715
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Background: Rice is a staple food for many people in the world and an important ingredient for production of food for infants and young children. According to European Food Safety Authority (EFSA), cereals, primarily rice and rice products, are an important source of human exposure to inorganic arsenic, which has been classified by the International Agency for Research on Cancer (IARC) as group I carcinogen. Arsenic is present in rice and rice products mainly as an inorganic form being more toxic than organic compounds Objectives: The aim of the study was to determine the total and inorganic arsenic content in rice, rice-based products including food for infants and young children available on the market in Poland and thus to estimate consumer exposure to inorganic arsenic from these groups of foodstuffs Materials and Methods: A total of 62 samples of rice and rice products from trade, including a group of rice products for infants and young children, were tested. Contents of total and inorganic arsenic were determined by using hydride generation atomic absorption spectrometry (HGAAS), after dry mineralization of samples and reduction of arsenic to arsenic hydride with sodium borohydride. To extract the inorganic arsenic forms, the samples were subjected to hydrolysis in concentrated HCl and then reduced in the presence of hydrobromic acid and hydrazine sulphate after which triple chloroform extractions and triple 1M HCl re-extractions were performed. Exposure of different groups of populations (adults and children), was estimated in relation to the Benchmark Dose Lower Confidence Limit (BMDL05) as set by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) that resulted in a 0.5% increase in lung cancer (3.0 µg/kg body weight (b.w.) per day) Results: Mean content of total and inorganic arsenic in investigated rice samples was 0.12 mg/kg (median: 0.09 mg/kg; 90th percentile 0.22 mg/kg) and 0.04 mg/kg (median: 0.03 mg/kg, 90th percentile 0.07 mg/kg). Brown rice was found to be more highly contaminated with both total and inorganic arsenic than white rice. Mean contamination of brown rice with total arsenic and inorganic arsenic was: 0.18 mg/kg (median: 0.12 mg/kg, 90th percentile: 0.32 mg/kg) and 0.05 mg/kg (median: 0.05 mg/kg, 90th percentile: 0.07 mg/kg). In turn for the white rice contamination was lower, mean total arsenic content: 0.10 mg/kg (median: 0.08 mg/kg, 90th percentile: 0.19 mg/kg) and mean inorganic arsenic: 0.03 mg/kg (median: 0.03 mg/kg, 90th percentile: 0.06 mg/kg). Contamination of rice-based products both total and inorganic arsenic was similar to those reported for rice, except rice wafers (mean: 0.24 mg/kg and 0.13 mg/kg). In the group of products for infants and young children obtained results were low ­ mean total arsenic content was 0.06 mg/kg and inorganic arsenic 0.02 mg/kg. The estimated average adult and children's exposure to inorganic arsenic with rice and rice products was less than 1% of the BMDL05. Intake of inorganic arsenic by 12-month-old infants with ricebased products intended for this group of population was at 6% BMDL05 Conclusions: Based on the obtained results, it was found that the content of total and inorganic arsenic in investigated samples of rice and rice products did not pose a health risk even though contamination levels in some individual samples were significant
[Mh] Termos MeSH primário: Arsenicais/análise
Carcinógenos/análise
Exposição Dietética/análise
Contaminação de Alimentos/análise
Oryza/química
[Mh] Termos MeSH secundário: Análise de Alimentos
Inocuidade dos Alimentos
Seres Humanos
Polônia
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenicals); 0 (Carcinogens)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


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[PMID]:29465554
[Au] Autor:Collinge E; Tigaud I; Balme B; Gerland LM; Sujobert P; Carlioz V; Salles G; Thomas X; Paubelle E
[Ad] Endereço:Department of Hematology, CHU UCL Namur, Belgium.
[Ti] Título:Case report: Purulent transformation of granulocytic sarcoma: An unusual pattern of differentiation in acute promyelocytic leukemia.
[So] Source:Medicine (Baltimore);97(8):e9657, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Acute promyelocytic leukemia (APL) is a curable subtype of acute myeloid leukemia. APL is currently treated with combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) resulting in the induction of apoptosis and differentiation of the leukemic cells. Differentiation syndrome (so-called ATRA syndrome) is the main life-threatening complication of induction therapy with these differentiating agents. PATIENT CONCERNS: Herein, we report the case of a 49-year-old woman diagnosed with APL with, concomitantly, a bulky cutaneous lesion of 10 cm diameter with a red-to-purple background and a necrotic center, localized on her abdomen. DIAGNOSES: After 10 days of treatment, the cutaneous lesion became purulent. Fluorescence in situ hybridization (FISH) analysis performed on this pus confirmed the presence of malignant features in the involved granulocytes proving their origin from the differentiation of leukemic APL cells, as all the analyzed nuclei showed 2 promyelocytic leukemia (PML)-retinoic acid receptor-a (RARA) fusions signals. INTERVENTION: The association by ATRA and ATO was continued. OUTCOME: Eventually, the evolution was favorable with healing in three weeks. LESSONS: This case report therefore highlights the differentiation phenomenon of promyelocytic blasts within promyelocytic sarcoma with the ATRA-ATO combination and the efficacy of this drug association in resolving both the malignant sarcoma and a secondary local infection.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos
Arsenicais/efeitos adversos
Leucemia Promielocítica Aguda/tratamento farmacológico
Óxidos/efeitos adversos
Sarcoma Mieloide/tratamento farmacológico
Tretinoína/efeitos adversos
[Mh] Termos MeSH secundário: Abdome/patologia
Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem
Arsenicais/administração & dosagem
Diferenciação Celular/efeitos dos fármacos
Feminino
Seres Humanos
Quimioterapia de Indução/efeitos adversos
Meia-Idade
Óxidos/administração & dosagem
Sarcoma Mieloide/induzido quimicamente
Sarcoma Mieloide/patologia
Supuração/induzido quimicamente
Tretinoína/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenicals); 0 (Oxides); 5688UTC01R (Tretinoin); S7V92P67HO (arsenic trioxide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009657


  4 / 6804 MEDLINE  
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[PMID]:29355690
[Au] Autor:Chiocchetti GM; Vélez D; Devesa V
[Ad] Endereço:Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), Calle Agustín Escardino 7, 46980, Paterna, Valencia, Spain.
[Ti] Título:Effect of subchronic exposure to inorganic arsenic on the structure and function of the intestinal epithelium.
[So] Source:Toxicol Lett;286:80-88, 2018 Apr.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Inorganic arsenic (As), the most toxic form of As found in water and food, is considered a human carcinogen. Numerous studies show its systemic toxicity, describing pathologies associated with chronic exposure. The main pathway of exposure to inorganic As is oral, but many of the events that occur during its passage through the gastrointestinal tract are unknown. This study evaluates the effect of subchronic exposure to inorganic As [As(III): 0.025-0.1 mg/L; As(V): 0.25-1 mg/L, up to 21 days] on the intestinal epithelium, using Caco-2 cells as in vitro model. Inorganic As produces a pro-inflammatory response throughout the exposure time, with an increase in IL-8 release (up to 488%). It also causes changes in the program of cell proliferation and differentiation, which leads to impairment of the cell repair process. In addition, subchronic exposure affects the epithelial structure, causing loss of microvilli, fundamental structures in the processes of intestinal absorption and digestion. Moreover, the exposure affects the epithelial barrier function, evidenced by an increase of Lucifer Yellow transport (103-199%). Therefore, it can be concluded that subchronic exposure to inorganic As can alter intestinal homeostasis, affecting the mucosal layer, which performs the most important functions of the intestinal wall.
[Mh] Termos MeSH primário: Células Epiteliais/efeitos dos fármacos
Mucosa Intestinal/efeitos dos fármacos
Óxidos/toxicidade
[Mh] Termos MeSH secundário: Arsenicais
Células CACO-2
Diferenciação Celular/efeitos dos fármacos
Movimento Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Digestão/efeitos dos fármacos
Relação Dose-Resposta a Droga
Células Epiteliais/metabolismo
Células Epiteliais/ultraestrutura
Regulação da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Mediadores da Inflamação/metabolismo
Interleucina-8/metabolismo
Absorção Intestinal/efeitos dos fármacos
Mucosa Intestinal/metabolismo
Mucosa Intestinal/ultraestrutura
Microvilosidades/efeitos dos fármacos
Microvilosidades/metabolismo
Microvilosidades/ultraestrutura
Permeabilidade
Medição de Risco
Fatores de Tempo
Testes de Toxicidade Subcrônica
Regulação para Cima
Cicatrização/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenicals); 0 (IL8 protein, human); 0 (Inflammation Mediators); 0 (Interleukin-8); 0 (Oxides); S7V92P67HO (arsenic trioxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE


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[PMID]:29307831
[Au] Autor:Wu B; Tan M; Cai W; Wang B; He P; Zhang X
[Ad] Endereço:Department of Orthopedics and Trauma Surgery, Central Hospital of Zhuzhou City and Affiliated Zhuzhou Hospital of Xiangya Medical College of Central South University, Hunan, 412000, China.
[Ti] Título:Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway.
[So] Source:Biochem Biophys Res Commun;496(1):167-175, 2018 01 29.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Osteosarcoma is a common primary malignant bone tumor, the cure rate of which has stagnated over the past 25-30 years. Autophagy modulation has been considered a potential therapeutic strategy for osteosarcoma, and previous study indicated that arsenic trioxide (ATO) exhibits significant anti-carcinogenic activity. However, the ability of ATO to induce autophagy and its role in osteosarcoma cell death remains unclear. In the present study, we showed that ATO increased autophagic flux in the human osteosarcoma cell line MG-63, as evidenced by the upregulation of LC3-II and downregulation of P62/SQSTM1. Moreover, the pharmacological or genetic blocking autophagy decreased ATO -induced cell death, indicating that ATO triggered autophagic cell death in MG-63 cells. Mechanistically, ATO induced TFEB dephosphorylation, activated TFEB nuclear translocation and increased TFEB reporter activity, which contributed to lysosomal biogenesis and the expression of autophagy-related genes and subsequently initiated autophagic cell death in MG-63 cells. Importantly, ATO triggered the generation of ROS in MG-63 cells. Furthermore, NAC, an ROS scavenger, abrogated the effects of ATO on TFEB-dependent autophagic cell death. Taken together, these data demonstrate that ATO induces osteosarcoma cell death via inducing excessive autophagy, which is mediated through the ROS-TFEB pathway. The present study provides a new anti-tumor mechanism of ATO treatment in osteosarcoma.
[Mh] Termos MeSH primário: Arsenicais/administração & dosagem
Autofagia/efeitos dos fármacos
Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/metabolismo
Óxidos/administração & dosagem
Espécies Reativas de Oxigênio/metabolismo
[Mh] Termos MeSH secundário: Antineoplásicos/administração & dosagem
Linhagem Celular Tumoral
Relação Dose-Resposta a Droga
Seres Humanos
Redes e Vias Metabólicas/efeitos dos fármacos
Osteossarcoma
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Arsenicals); 0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors); 0 (Oxides); 0 (Reactive Oxygen Species); 0 (TFEB protein, human); S7V92P67HO (arsenic trioxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180109
[St] Status:MEDLINE


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[PMID]:29309887
[Au] Autor:Asik A; Kayabasi C; Ozmen Yelken B; Yilmaz Susluer S; Dogan Sigva ZO; Balci Okcanoglu T; Saydam G; Biray Avci C; Gunduz C
[Ad] Endereço:Ege University, Faculty of Medicine, Department of Medical Biology, Izmir, Turkey. Electronic address: aycan.asik@ege.edu.tr.
[Ti] Título:Antileukemic effect of paclitaxel in combination with metformin in HL-60 cell line.
[So] Source:Gene;647:213-220, 2018 Mar 20.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Acute promyelocytic leukemia (APL) is a subtype of AML that is a mixture of hematological malignancy, characterized by a specific translocation t(15;17). The using of all-trans retinoic acid (ATRA) with arsenic trioxide (ATO) or chemotherapeutic agents or both of these agents, composes main treatment strategy of APL. While it is possible to achieve success in treatment of low-risk APL with current treatment regimens, such success is not mentioned in high-risk APL. So, it may develop new approaches for treatment regimens for high-risk APL. In the present study, we aimed to investigate the effects of combinational of a classic anticancer agent paclitaxel and antidiabetic agent metformin on HL-60 APL cell line. The combination dose of paclitaxel and metformin was determined by WST-1 analysis. The effect of combinational dose on apoptosis was assessed in fluorescence microscope after using AnnexinV-EGFP Apoptosis and JC-1 Assay Kit. The effect of combinational dose on cell cycle, apoptosis and differentiation, and signaling pathways were determined investigating gene expression changes by using real time qRT-PCR. The combinational dose of paclitaxel and metformin was determined as 4.8nM and 398.7µM for 72h, respectively. The combination dose significantly increased apoptosis for 48h. In expression changes of genes associated cell cycle, apoptosis, cytokines, co-stimulator molecules, NF-kB and MAP/MAPK pathways, TLRs (Toll-like receptors) were found to be decreased or increased to provide apoptosis or differentiation. Consequently, we suggest that the combination of paclitaxel and metformin can be used as an option assessable for development of new treatment strategies for APL.
[Mh] Termos MeSH primário: Antineoplásicos/envenenamento
Leucemia Promielocítica Aguda/tratamento farmacológico
Metformina/farmacologia
Paclitaxel/farmacologia
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Arsenicais/farmacologia
Ciclo Celular/efeitos dos fármacos
Diferenciação Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Quimioterapia Combinada/métodos
Células HL-60
Seres Humanos
Leucemia Promielocítica Aguda/metabolismo
NF-kappa B/metabolismo
Óxidos/farmacologia
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Arsenicals); 0 (NF-kappa B); 0 (Oxides); 9100L32L2N (Metformin); P88XT4IS4D (Paclitaxel); S7V92P67HO (arsenic trioxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180109
[St] Status:MEDLINE


  7 / 6804 MEDLINE  
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[PMID]:29107877
[Au] Autor:Lin S; Yang H; Na Z; Lin K
[Ad] Endereço:State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, East China University of Science and Technology, Shanghai, 200237, China. Electronic address: linsen@ecust.edu.cn.
[Ti] Título:A novel biodegradable arsenic adsorbent by immobilization of iron oxyhydroxide (FeOOH) on the root powder of long-root Eichhornia crassipes.
[So] Source:Chemosphere;192:258-266, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, FeOOH was immobilized on the biodegradable root powder, abbreviated as RP, of long-root Eichhornia crassipes, a kind of waste biomass, to improve the adsorption performances for aqueous arsenic contaminants. The adsorption kinetics and thermodynamics experiments showed that the adsorption rates and capacities of the root powder for arsenate (As(V)) and arsenite (As(III)) were both enhanced markedly after modification with FeOOH. The adsorption of As(V) and As(III) by the modified root powder, abbreviated as MRP, could arrive at equilibrium in 50 min and the saturated adsorption capacities reached up to 8.67-9.43 mg/g for As(V) and 5.21-5.65 mg/g for As(V) at temperature of 10-50 °C, respectively. Besides, the effect of pH and ionic strength on adsorption was investigated and the results showed that the optimum pH for the arsenic adsorption using the MRP was 9.0 and the As(V) adsorption was more sensitive to ionic strength. Furthermore, the complexation of hydratable hydroxyls on FeOOH with arsenic contaminants was concluded as the adsorption force according FTIR and XPS analyses. The MRP used could be regenerated via 0.4 mol/L NaOH solution and no apparent adsorption capacity losses appeared after 6 cyclic utilizations.
[Mh] Termos MeSH primário: Arsenicais/metabolismo
Eichhornia/metabolismo
Preparações de Plantas/metabolismo
Poluentes Químicos da Água/metabolismo
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Adsorção
Arseniatos/metabolismo
Arsênico/metabolismo
Arsenitos/metabolismo
Compostos Férricos/metabolismo
Concentração de Íons de Hidrogênio
Concentração Osmolar
Raízes de Plantas/metabolismo
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenates); 0 (Arsenicals); 0 (Arsenites); 0 (Ferric Compounds); 0 (Plant Preparations); 0 (Water Pollutants, Chemical); 2UA751211N (ferric hydroxide); N5509X556J (arsenite); N712M78A8G (Arsenic); N7CIZ75ZPN (arsenic acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171107
[St] Status:MEDLINE


  8 / 6804 MEDLINE  
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[PMID]:28966030
[Au] Autor:Cui JL; Zhao YP; Li JS; Beiyuan JZ; Tsang DCW; Poon CS; Chan TS; Wang WX; Li XD
[Ad] Endereço:Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
[Ti] Título:Speciation, mobilization, and bioaccessibility of arsenic in geogenic soil profile from Hong Kong.
[So] Source:Environ Pollut;232:375-384, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The behaviour of arsenic (As) from geogenic soil exposed to aerobic conditions is critical to predict the impact of As on the environment, which processes remain unresolved. The current study examined the depth profile of As in geologically derived subsoil cores from Hong Kong and investigated the mobilization, plant availability, and bioaccessibility of As in As-contaminated soil at different depths (0-45.8 m). Results indicated significant heterogeneity, with high levels of As in three layers of soil reaching up to 505 mg/kg at a depth of 5 m, 404 mg/kg at a depth of 15 m, and 1510 mg/kg at a depth of 27-32 m. Arsenic in porewater samples was <11.5 µg/L in the study site. X-ray absorption spectroscopy (XAS) indicated that main As species in soil was arsenate (As(V)), as adsorbed fraction to Fe oxides (41-69% on goethite and 0-8% on ferrihydrite) or the mineral form scorodite (30-57%). Sequential extraction procedure demonstrated that 0.5 ± 0.4% of As was exchangeable. Aerobic incubation experiments exhibited that a very small amount (0.14-0.48 mg/kg) of As was desorbed from the soil because of the stable As(V) complex structure on abundant Fe oxides (mainly goethite), where indigenous microbes partly (59 ± 18%) contributed to the release of As comparing with the sterilized control. Furthermore, no As toxicity in the soil was observed with the growth of ryegrass. The bioaccessibility of As was <27% in the surface soil using simplified bioaccessibility extraction test. Our systematic evaluation indicated that As in the geogenic soil profile from Hong Kong is relatively stable exposing to aerobic environment. Nevertheless, children and workers should avoid incidental contact with excavated soil, because high concentration of As was present in the digestive solution (<0.1-268 µg/L).
[Mh] Termos MeSH primário: Arsênico/análise
Monitoramento Ambiental
Poluentes do Solo/análise
[Mh] Termos MeSH secundário: Adsorção
Arsenicais
Criança
Poluição Ambiental/estatística & dados numéricos
Compostos Férricos
Hong Kong
Seres Humanos
Compostos de Ferro
Minerais
Óxidos
Solo/química
Espectroscopia por Absorção de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenicals); 0 (Ferric Compounds); 0 (Iron Compounds); 0 (Minerals); 0 (Oxides); 0 (Soil); 0 (Soil Pollutants); 0 (scorodite); 1310-14-1 (goethite); 87PZU03K0K (ferric oxyhydroxide); N712M78A8G (Arsenic)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE


  9 / 6804 MEDLINE  
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[PMID]:28466809
[Au] Autor:Wang L; Guo Q; Liu W; Bai Y
[Ad] Endereço:Chengdu Women's and Children's Central Hospital, Chengdu, Sichuan Province, China.
[Ti] Título:A proteomics research of apoptosis of leukemia cells induced by arsenic trioxide.
[So] Source:Cell Mol Biol (Noisy-le-grand);63(3):7-11, 2017 Mar 31.
[Is] ISSN:1165-158X
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Leukemia is a malignant hyperplasia disease of hematopoietic system caused by a kind of hematopoietic cells detaining at a certain stage. In this study, we used HL-60 cell line to detect the effect of apoptosis induction by various concentrations of As2O3. Percentage of apoptotic cells was increased in the presence of As2O3, detected through flow cytometry. Mass spectrometric identification indicated that there were 102 differential proteins before and after intervention. Among them, expression of CH60, AT1A1, ANXA6, and EF2 increased and expression of ATPA, MYO1G, RS3 decreased. Those genes played roles in promoting HL-60 cell apoptosis induced by As2O3. This study could lay the foundation of deciphering mechanisms of HL-60 cell apoptosis and give a new possible target to the clinical application for arsenic trioxide treatment for leukemia.
[Mh] Termos MeSH primário: Apoptose
Arsenicais/farmacologia
Leucemia/patologia
Óxidos/farmacologia
Proteômica
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Apoptose/efeitos dos fármacos
Forma Celular/efeitos dos fármacos
Células HL-60
Seres Humanos
Espectrometria de Massas
Proteínas de Neoplasias/química
Proteínas de Neoplasias/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenicals); 0 (Neoplasm Proteins); 0 (Oxides); S7V92P67HO (arsenic trioxide)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.14715/cmb/2017.63.3.2


  10 / 6804 MEDLINE  
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[PMID]:29216971
[Au] Autor:Chávez-Capilla T; Maher W; Kelly T; Foster S
[Ad] Endereço:Ecochemistry Laboratory, Institute for Applied Ecology, University of Canberra, Canberra, ACT 2601, Australia. Electronic address: Teresa.GonzalezdeChavezCapila@canberra.edu.au.
[Ti] Título:Evaluation of the ability of arsenic species to traverse cell membranes by simple diffusion using octanol-water and liposome-water partition coefficients.
[So] Source:J Environ Sci (China);49:222-232, 2016 Nov.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Arsenic metabolism in living organisms is dependent on the ability of different arsenic species to traverse biological membranes. Simple diffusion provides an alternative influx and efflux route to mediated transport mechanisms that can increase the amount of arsenic available for metabolism in cells. Using octanol-water and liposome-water partition coefficients, the ability of arsenous acid, arsenate, methylarsonate, dimethylarsinate, thio-methylarsonate, thio-dimethylarsinic acid, arsenotriglutathione and monomethylarsonic diglutathione to diffuse through the lipid bilayer of cell membranes was investigated. Molecular modelling of arsenic species was used to explain the results. All arsenic species with the exception of arsenate, methylarsonate and thio-methylarsonate were able to diffuse through the lipid bilayer of liposomes, with liposome-water partition coefficients between 0.04 and 0.13. Trivalent arsenic species and thio-pentavalent arsenic species showed higher partition coefficients, suggesting that they can easily traverse cell membranes by passive simple diffusion. Given the higher toxicity of these species compared to oxo-pentavalent arsenic species, this study provides evidence supporting the risk associated with human exposure to trivalent and thio-arsenic species.
[Mh] Termos MeSH primário: Arsênico/metabolismo
Membrana Celular/metabolismo
Poluentes Químicos da Água/metabolismo
[Mh] Termos MeSH secundário: Arseniatos
Arsênico/toxicidade
Arsenicais
Arsenitos
Difusão
Glutationa/análogos & derivados
Seres Humanos
Lipossomos
Octanóis
Água
Poluentes Químicos da Água/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenates); 0 (Arsenicals); 0 (Arsenites); 0 (Liposomes); 0 (Octanols); 0 (Water Pollutants, Chemical); 0 (arsenotriglutathione); 059QF0KO0R (Water); 935XD1L5K2 (arsenous acid); GAN16C9B8O (Glutathione); J37VJ5709S (monomethylarsonic acid); N712M78A8G (Arsenic); N7CIZ75ZPN (arsenic acid)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE



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