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[PMID]:29175405
[Au] Autor:Yang F; Xie S; Liu J; Wei C; Zhang H; Chen T; Zhang J
[Ad] Endereço:Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, China; Key Laboratory of Land Surface Pattern and Simulation, Chinese Academy of Sciences, Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
[Ti] Título:Arsenic concentrations and speciation in wild birds from an abandoned realgar mine in China.
[So] Source:Chemosphere;193:777-784, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Birds are at a higher level in the food chain; however, the potential bioaccumulation and biotransformation of arsenic (As) in birds in As mines has rarely been studied. In this study, four passerine bird species (tree sparrow [Passer montanus], light-vented bulbul [Pycnonotus sinensis], Garrulax canorus [Leucodioptron canorus], and magpie [Pica pica]) were collected from an abandoned As mine in China. The highest recorded As concentrations were 4.95 mg/kg and 51.65 mg/kg in muscles and feathers, respectively. Detection using high-performance liquid chromatography inductively coupled plasma mass spectrometry (HPLC-ICP-MS) revealed six As species, including arsenite (As(III)), arsenate (As(V)), dimethylarsinic acid (DMA), monomethylarsonic acid (MMA), arsenobetaine (AsB) and arsenocholine (AsC), with the former three species as the dominant (>92%) and the latter three as the minor As species (<6.17%). Further analysis of the selected bird samples using the X-ray absorption near edge structure (XANES) technique revealed the existence of As(III)-tris-glutathione (As(III)-GSH), which can be regarded as equivalent to the non-extractable and unidentified As form in the HPLC-ICP-MS data. Both methods revealed similar patterns of As species in the birds from the As mine, with muscles containing mainly inorganic As and DMA and feathers containing mainly inorganic As. The results of this study contribute to the knowledge regarding As accumulation and speciation in terrestrial organisms.
[Mh] Termos MeSH primário: Arsênico/análise
Arsenicais/análise
Aves
Mineração
[Mh] Termos MeSH secundário: Animais
Arseniatos
Arsênico/química
Arsenitos
Ácido Cacodílico/análise
China
Cromatografia Líquida de Alta Pressão/métodos
Plumas/química
Espectrometria de Massas/métodos
Músculo Esquelético/química
Passeriformes
Sulfetos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenates); 0 (Arsenicals); 0 (Arsenites); 0 (Sulfides); 39895-81-3 (arsenocholine); 56320-22-0 (arsenic disulfide); AJ2HL7EU8K (Cacodylic Acid); J37VJ5709S (monomethylarsonic acid); N5509X556J (arsenite); N712M78A8G (Arsenic); N7CIZ75ZPN (arsenic acid); UWC1LS4V3I (arsenobetaine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:28837873
[Au] Autor:Kim J; Lee C; Lee SM; Lalhmunsiama; Jung J
[Ad] Endereço:Division of Environmental Science and Ecological Engineering, Korea University, Seoul 02841, Republic of Korea.
[Ti] Título:Chemical and toxicological assessment of arsenic sorption onto Fe-sericite composite powder and beads.
[So] Source:Ecotoxicol Environ Saf;147:80-85, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Batch sorption and leaching of arsenic (1-30mgL ) on Fe-sericite composite powder and beads were investigated in this study. Fe-sericite composite powder was made from natural sericite modified with iron, and alginate was used to transform the powder into beads. The maximum sorption capacities of the Fe-sericite composite powder (15.04 and 13.21mgg for As(III) and As(V), respectively) were higher than those of the corresponding beads (9.02 and 7.11mgg for As(III) and As(V), respectively) owing to the higher specific surface area of the powder. In addition, the leaching amounts of As(III) from Fe-sericite composite beads (≤ 15.03%) were higher than those of the corresponding powder (≤ 5.71%). However, acute toxicity of As(III)-sorbed Fe-sericite composite beads toward Daphnia magna was not significantly different from that of the corresponding powder (p > 0.05). Considering higher uptake of the powder particles by the daphnids, Fe-sericite composite beads seem to be a more appropriate and safer sorbent for arsenic removal in practical application. Based on Fe content, Fe-sericite composite beads had similar or higher maximum sorption capacities (71.19 and 56.11mgg Fe for As(III) and As(V), respectively) than those of previously reported sorbents.
[Mh] Termos MeSH primário: Arseniatos/análise
Arsenitos/análise
Ferro/química
Dióxido de Silício/química
Poluentes Químicos da Água/análise
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Adsorção
Alginatos/química
Animais
Arseniatos/toxicidade
Arsenitos/toxicidade
Daphnia/efeitos dos fármacos
Ácido Glucurônico/química
Ácidos Hexurônicos/química
Modelos Teóricos
Tamanho da Partícula
Pós
Propriedades de Superfície
Testes de Toxicidade Aguda
Poluentes Químicos da Água/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alginates); 0 (Arsenates); 0 (Arsenites); 0 (Hexuronic Acids); 0 (Powders); 0 (Water Pollutants, Chemical); 0 (sericite); 7631-86-9 (Silicon Dioxide); 8A5D83Q4RW (Glucuronic Acid); 8C3Z4148WZ (alginic acid); E1UOL152H7 (Iron)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE


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[PMID]:28469096
[Au] Autor:Wang XN; Zhang CJ; Diao HL; Zhang Y
[Ad] Endereço:Reproductive Medical Center of Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China.
[Ti] Título:Protective Effects of Curcumin against Sodium Arsenite-induced Ovarian Oxidative Injury in a Mouse Model.
[So] Source:Chin Med J (Engl);130(9):1026-1032, 2017 May 05.
[Is] ISSN:0366-6999
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Excessive reactive oxygen species (ROS) may lead to a number of reproductive diseases such as polycystic ovary syndrome. This study aimed to establish an animal model of ovarian oxidative stress and to assess the protective effect of curcumin against oxidative injury. METHODS: Ovarian oxidative stress was induced in female Kunming mice (n = 40) with intraperitoneal injection of 8 mg/kg sodium arsenite (As) once every other day for 16 days; meanwhile, they were, respectively, treated by intragastric administration of 0, 100, 150, or 200 mg/kg (n = 10/group) curcumin once per day for 21 days. Ten normal mice were used as control. Then, the mice were injected intraperitoneally with BrdU and sacrificed; the right ovaries were collected for hematoxylin and eosin (HE) staining and BrdU immunohistochemistry, and the left ovaries for enzyme-linked immunosorbent assay (ELISA) and Western blotting analyses. RESULTS: The ELISA results showed that ROS (11.74 ± 0.65 IU/mg in 8 mg/kg AS + 0 mg/kg curcumin group vs. 10.71 ± 0.91 IU/mg in control group, P= 0.021) and malondialdehyde (MDA) (0.32 ± 0.02 nmol/g in 8 mg/kg AS + 0 mg/kg curcumin group vs. 0.27 ± 0.02 nmol/g in control group, P= 0.048) increased while superoxide dismutase (SOD) (3.96 ± 0.36 U/mg in 8 mg/kg AS + 0 mg/kg curcumin group vs. 4.51 ± 0.70 U/mg in control group, P= 0.012) and glutathione peroxidase (17.36 ± 1.63 U/g in 8 mg/kg AS + 0 mg/kg curcumin group vs. 18.92 ± 1.80 U/g in control group, P= 0.045) decreased in the ovary after injection of As, indicating successful modeling of oxidative stress. Curcumin treatment could considerably increase SOD (4.57 ± 0.68, 4.49 ± 0.27, and 4.56 ± 0.25 U/mg in 100 mg/kg, 150 mg/kg, and 200 mg/kg curcumin group, respectively, allP < 0.05) while significantly reduce ROS (10.64 ± 1.38, 10.73 ± 0.71, and 10.67 ± 1.38 IU/mg in 100 mg/kg, 150 mg/kg, and 200 mg/kg curcumin group, respectively, allP < 0.05) and MDA (0.28 ± 0.02, 0.25 ± 0.03, and 0.27 ± 0.04 nmol/g in 100 mg/kg, 150 mg/kg, and 200 mg/kg curcumin group, respectively; bothP < 0.05) in the ovary. HE staining and BrdU immunohistochemistry of the ovarian tissues indicated the increased amount of atretic follicles (5.67 ± 0.81, 5.84 ± 0.98, and 5.72 ± 0.84 in 100 mg/kg, 150 mg/kg, and 200 mg/kg curcumin group, respectively, all P < 0.05), and the inhibited proliferation of granular cells under oxidative stress would be reversed by curcumin. Furthermore, the Western blotting of ovarian tissues showed that the p66Shc expression upregulated under oxidative stress would be lowered by curcumin. CONCLUSION: Curcumin could alleviate arsenic-induced ovarian oxidative injury to a certain extent.
[Mh] Termos MeSH primário: Arsenitos/toxicidade
Curcumina/uso terapêutico
Compostos de Sódio/toxicidade
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Ensaio de Imunoadsorção Enzimática
Feminino
Glutationa Peroxidase/metabolismo
Imuno-Histoquímica
Malondialdeído/metabolismo
Camundongos
Ovário/efeitos dos fármacos
Ovário/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Síndrome do Ovário Policístico/tratamento farmacológico
Síndrome do Ovário Policístico/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenites); 0 (Reactive Oxygen Species); 0 (Sodium Compounds); 48OVY2OC72 (sodium arsenite); 4Y8F71G49Q (Malondialdehyde); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.4103/0366-6999.204927


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[PMID]:28966026
[Au] Autor:Niazi NK; Bibi I; Shahid M; Ok YS; Burton ED; Wang H; Shaheen SM; Rinklebe J; Lüttge A
[Ad] Endereço:Institute of Soil and Environmental Sciences, University of Agriculture Faisalabad, Faisalabad 38040, Pakistan; MARUM and Department of Geosciences, University of Bremen, Bremen D-28359, Germany; Southern Cross GeoScience, Southern Cross University, Lismore 2480 NSW, Australia. Electronic address: n
[Ti] Título:Arsenic removal by perilla leaf biochar in aqueous solutions and groundwater: An integrated spectroscopic and microscopic examination.
[So] Source:Environ Pollut;232:31-41, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, we examined the removal of arsenite (As(III)) and arsenate (As(V)) by perilla leaf-derived biochars produced at 300 and 700 °C (referred as BC300 and BC700) in aqueous environments. Results revealed that the Langmuir isotherm model provided the best fit for As(III) and As(V) sorption, with the sorption affinity following the order: BC700-As(III) > BC700-As(V) > BC300-As(III) > BC300-As(V) (Q = 3.85-11.01 mg g ). In general, As removal decreased (76-60%) with increasing pH from 7 to 10 except for the BC700-As(III) system, where notably higher As removal (88-90%) occurred at pH from 7 to 9. Surface functional moieties contributed to As sequestration by the biochars examined here. However, significantly higher surface area and aromaticity of BC700 favored a greater As removal compared to BC300, suggesting that surface complexation/precipitation dominated As removal by BC700. Arsenic K-edge X-ray absorption near edge structure (XANES) spectroscopy demonstrated that up to 64% of the added As(V) was reduced to As(III) in BC700- and BC300-As(V) sorption experiments, and in As(III) sorption experiments, partial oxidation of As(III) to As(V) occurred (37-39%). However, XANES spectroscopy was limited to precisely quantify As binding with sulfur species as As S -like phase. Both biochars efficiently removed As from natural As-contaminated groundwater (As: 23-190 µg L ; n = 12) despite in the presence of co-occurring anions (e.g., CO , PO , SO ) with the highest levels of As removal observed for BC700 (97-100%). Overall, this study highlights that perilla leaf biochars, notably BC700, possessed the greatest ability to remove As from solution and groundwater (drinking water). Significantly, the integrated spectroscopic techniques advanced our understanding to examine complex redox transformation of As(III)/As(V) with biochar, which are crucial to determine fate of As on biochar in aquatic environments.
[Mh] Termos MeSH primário: Arsênico/química
Carvão Vegetal/química
Poluentes Químicos da Água/química
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Adsorção
Arseniatos
Arsênico/análise
Arsenitos
Água Subterrânea/química
Oxirredução
Perilla
Folhas de Planta/química
Poluentes Químicos da Água/análise
Espectroscopia por Absorção de Raios X
Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenates); 0 (Arsenites); 0 (Water Pollutants, Chemical); 0 (biochar); 16291-96-6 (Charcoal); N5509X556J (arsenite); N712M78A8G (Arsenic); N7CIZ75ZPN (arsenic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE


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[PMID]:29107877
[Au] Autor:Lin S; Yang H; Na Z; Lin K
[Ad] Endereço:State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, East China University of Science and Technology, Shanghai, 200237, China. Electronic address: linsen@ecust.edu.cn.
[Ti] Título:A novel biodegradable arsenic adsorbent by immobilization of iron oxyhydroxide (FeOOH) on the root powder of long-root Eichhornia crassipes.
[So] Source:Chemosphere;192:258-266, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, FeOOH was immobilized on the biodegradable root powder, abbreviated as RP, of long-root Eichhornia crassipes, a kind of waste biomass, to improve the adsorption performances for aqueous arsenic contaminants. The adsorption kinetics and thermodynamics experiments showed that the adsorption rates and capacities of the root powder for arsenate (As(V)) and arsenite (As(III)) were both enhanced markedly after modification with FeOOH. The adsorption of As(V) and As(III) by the modified root powder, abbreviated as MRP, could arrive at equilibrium in 50 min and the saturated adsorption capacities reached up to 8.67-9.43 mg/g for As(V) and 5.21-5.65 mg/g for As(V) at temperature of 10-50 °C, respectively. Besides, the effect of pH and ionic strength on adsorption was investigated and the results showed that the optimum pH for the arsenic adsorption using the MRP was 9.0 and the As(V) adsorption was more sensitive to ionic strength. Furthermore, the complexation of hydratable hydroxyls on FeOOH with arsenic contaminants was concluded as the adsorption force according FTIR and XPS analyses. The MRP used could be regenerated via 0.4 mol/L NaOH solution and no apparent adsorption capacity losses appeared after 6 cyclic utilizations.
[Mh] Termos MeSH primário: Arsenicais/metabolismo
Eichhornia/metabolismo
Preparações de Plantas/metabolismo
Poluentes Químicos da Água/metabolismo
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Adsorção
Arseniatos/metabolismo
Arsênico/metabolismo
Arsenitos/metabolismo
Compostos Férricos/metabolismo
Concentração de Íons de Hidrogênio
Concentração Osmolar
Raízes de Plantas/metabolismo
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenates); 0 (Arsenicals); 0 (Arsenites); 0 (Ferric Compounds); 0 (Plant Preparations); 0 (Water Pollutants, Chemical); 2UA751211N (ferric hydroxide); N5509X556J (arsenite); N712M78A8G (Arsenic); N7CIZ75ZPN (arsenic acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171107
[St] Status:MEDLINE


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[PMID]:29216971
[Au] Autor:Chávez-Capilla T; Maher W; Kelly T; Foster S
[Ad] Endereço:Ecochemistry Laboratory, Institute for Applied Ecology, University of Canberra, Canberra, ACT 2601, Australia. Electronic address: Teresa.GonzalezdeChavezCapila@canberra.edu.au.
[Ti] Título:Evaluation of the ability of arsenic species to traverse cell membranes by simple diffusion using octanol-water and liposome-water partition coefficients.
[So] Source:J Environ Sci (China);49:222-232, 2016 Nov.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Arsenic metabolism in living organisms is dependent on the ability of different arsenic species to traverse biological membranes. Simple diffusion provides an alternative influx and efflux route to mediated transport mechanisms that can increase the amount of arsenic available for metabolism in cells. Using octanol-water and liposome-water partition coefficients, the ability of arsenous acid, arsenate, methylarsonate, dimethylarsinate, thio-methylarsonate, thio-dimethylarsinic acid, arsenotriglutathione and monomethylarsonic diglutathione to diffuse through the lipid bilayer of cell membranes was investigated. Molecular modelling of arsenic species was used to explain the results. All arsenic species with the exception of arsenate, methylarsonate and thio-methylarsonate were able to diffuse through the lipid bilayer of liposomes, with liposome-water partition coefficients between 0.04 and 0.13. Trivalent arsenic species and thio-pentavalent arsenic species showed higher partition coefficients, suggesting that they can easily traverse cell membranes by passive simple diffusion. Given the higher toxicity of these species compared to oxo-pentavalent arsenic species, this study provides evidence supporting the risk associated with human exposure to trivalent and thio-arsenic species.
[Mh] Termos MeSH primário: Arsênico/metabolismo
Membrana Celular/metabolismo
Poluentes Químicos da Água/metabolismo
[Mh] Termos MeSH secundário: Arseniatos
Arsênico/toxicidade
Arsenicais
Arsenitos
Difusão
Glutationa/análogos & derivados
Seres Humanos
Lipossomos
Octanóis
Água
Poluentes Químicos da Água/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenates); 0 (Arsenicals); 0 (Arsenites); 0 (Liposomes); 0 (Octanols); 0 (Water Pollutants, Chemical); 0 (arsenotriglutathione); 059QF0KO0R (Water); 935XD1L5K2 (arsenous acid); GAN16C9B8O (Glutathione); J37VJ5709S (monomethylarsonic acid); N712M78A8G (Arsenic); N7CIZ75ZPN (arsenic acid)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


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[PMID]:27774770
[Au] Autor:Chen C; Jiang X; Gu S; Lai Y; Liu Y; Zhang Z
[Ad] Endereço:Department of Occupational and Environmental Health, West China School of Public Health, Sichuan University, Chengdu, Sichuan, People's Republic of China.
[Ti] Título:Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway.
[So] Source:Environ Toxicol;32(8):2004-2020, 2017 Aug.
[Is] ISSN:1522-7278
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Arsenite has been shown to induce a variety of oxidative damage in mammalian cells. However, the mechanisms underlying cellular responses to its adverse effects remain unknown. We previously showed that the level of Nrf2, a nuclear transcription factor significantly increased in arsenite-treated human bronchial epithelial (HBE) cells suggesting that Nrf2 is involved in responding to arsenite-induced oxidative damage. To explore how Nrf2 can impact arsenite-induced oxidative damage, in this study, we examined Nrf2 activation and its regulation upon cellular arsenite exposure as well as its effects on arsenite-induced oxidative damage in HBE cells. We found that Nrf2 mRNA and protein levels were significantly increased by arsenite in a dose- and time-dependent manner. Furthermore, we showed that over-expression of Nrf2 significantly reduced the level of arsenite-induced oxidative damage in HBE cells including DNA damage, chromosomal breakage, lipid peroxidation and depletion of antioxidants. This indicates a protective role of Nrf2 against arsenite toxicity. This was further supported by the fact that activation of Nrf2 by its agonists, tertiary butylhydroquinone (t-BHQ) and sulforaphane (SFN) resulted in the same protective effects against arsenite toxicity. Moreover, we demonstrated that arsenite-induced activation of Nrf2 was mediated by the cyclic guanosine monophosphate (cGMP)-protein kinase G (PKG) signaling pathway. This is the first evidence showing that Nrf2 protects against arsenite-induced oxidative damage through the cGMP-PKG pathway. Our study suggests that activation of Nrf2 through the cGMP-PKG signaling pathway in HBE cells may be developed as a new strategy for prevention of arsenite toxicity. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 2004-2020, 2017.
[Mh] Termos MeSH primário: Arsenitos/toxicidade
Proteínas Quinases Dependentes de GMP Cíclico/metabolismo
Fator 2 Relacionado a NF-E2/metabolismo
Estresse Oxidativo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antioxidantes/metabolismo
Linhagem Celular
Seres Humanos
Hidroquinonas/farmacologia
Isotiocianatos/farmacologia
Fator 2 Relacionado a NF-E2/agonistas
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Arsenites); 0 (Hydroquinones); 0 (Isothiocyanates); 0 (NF-E2-Related Factor 2); C12674942B (2-tert-butylhydroquinone); EC 2.7.11.12 (Cyclic GMP-Dependent Protein Kinases); GA49J4310U (sulforafan); N5509X556J (arsenite)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1002/tox.22374


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[PMID]:28888487
[Au] Autor:Liu X; Ling M; Chen C; Luo F; Yang P; Wang D; Chen X; Xu H; Xue J; Yang Q; Lu L; Lu J; Bian Q; Zhang A; Liu Q
[Ad] Endereço:Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, People's Republic of China; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, People's Republic of China.
[Ti] Título:Impaired autophagic flux and p62-mediated EMT are involved in arsenite-induced transformation of L-02 cells.
[So] Source:Toxicol Appl Pharmacol;334:75-87, 2017 Nov 01.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Autophagy is a catabolic process essential for preserving cellular homeostasis, and the epithelial-to-mesenchymal transition (EMT) is involved during tissue development and cancer progression. In arsenite-treated human hepatic epithelial (L-02) cells, arsenite reduced the autophagic flux, which caused accumulation of p62, an adaptor and receptor of autophagy. Further, in arsenite-transformed L-02 cells, the levels of E-cadherin were attenuated, but the levels of vimentin, which is expressed in mesenchymal cells, and Snail, a transcription regulator of the EMT, were up-regulated. Thus, after chronic exposure of L-02 cells to arsenite, the impaired autophagic flux induced the accumulation of p62, which up-regulated the expression of Snail, a protein involved in arsenite-induced EMT of these cells. Knockdown of p62 by siRNA reversed the arsenite-induced EMT and decreased the capacities of arsenite-transformed L-02 cells for colony formation and invasion and migration. Therefore, in arsenite-induced transformation of L-02 cells, the accumulation of p62, by impairing autophagic flux, mediates the EMT via Snail. These results provide a previously unknown mechanism underlying arsenic toxicity and carcinogenicity.
[Mh] Termos MeSH primário: Arsenitos/toxicidade
Autofagia/efeitos dos fármacos
Transição Epitelial-Mesenquimal/efeitos dos fármacos
Regulação da Expressão Gênica/efeitos dos fármacos
Hepatócitos/efeitos dos fármacos
Proteínas de Ligação a RNA/metabolismo
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Seres Humanos
Proteínas de Ligação a RNA/genética
Fatores de Transcrição da Família Snail/genética
Fatores de Transcrição da Família Snail/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenites); 0 (P62 protein, human); 0 (RNA-Binding Proteins); 0 (SNAI1 protein, human); 0 (Snail Family Transcription Factors); N5509X556J (arsenite)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170911
[St] Status:MEDLINE


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[PMID]:28867001
[Au] Autor:Tapase SR; Mawlankar RB; Sundharam SS; Krishnamurthi S; Dastager SG; Kodam KM
[Ad] Endereço:1​Division of Biochemistry, Department of Chemistry, Savitribai Phule Pune University, Pune-411007, Maharashtra, India.
[Ti] Título:Microvirga indica sp. nov., an arsenite-oxidizing Alphaproteobacterium, isolated from metal industry waste soil.
[So] Source:Int J Syst Evol Microbiol;67(9):3525-3531, 2017 Sep.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel Gram-stain-negative bacterium, strain S-MI1bT, belonging to the genus Microvirga was isolated from a metal industry waste soil sample in Pirangut village, Pune District, Maharashtra, India. Cells were non-spore-forming, small rod-shapes, motile and strictly aerobic with light-pink colonies. The strain grew in 0-7.0 % (w/v) NaCl and at 25-45 °C, with optimal growth at 40 °C. The predominant fatty acids detected were summed feature 8 (C18 : 1 ω7c and/or C18 : 1 ω6c) and C19 : 0 cyclo ω8c. The predominant isoprenoid quinone was Q-10. The G+C content was 67.2 mol% and DNA-DNA relatedness values between strain S-MI1bTand Microvirga subterranea DSM 14364T and Microvirgaaerophila 5420S-12T were 53.9 and 54.8 %, respectively. Phylogenetic analysis, based on 16S rRNA gene sequences, indicated that strain S-MI1bT is a member of the genus Microvirga, with greatest sequence similarities of 97.7 and 97.4 % with M. subterranea DSM 14364T and M.aerophila 5420S-12T, respectively. Phylogenetic analysis showed that strain S-MI1bT forms a clade with the type strain of M. subterranea DSM 14364T, and was readily distinguishable from it due to various phenotypic characteristics. The combination of genotypic and phenotypic data suggests that the isolate represents a novel species of the genus Microvirga, for which the name Microvirga indica sp. nov. is proposed. The type strain is S-MI1bT (=NCIM-5595T=KACC 18792T=BCRC 80972T).
[Mh] Termos MeSH primário: Arsenitos/metabolismo
Resíduos Industriais
Methylobacteriaceae/classificação
Filogenia
Microbiologia do Solo
[Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana
Composição de Bases
DNA Bacteriano/genética
Ácidos Graxos/química
Índia
Metais
Methylobacteriaceae/genética
Methylobacteriaceae/isolamento & purificação
Hibridização de Ácido Nucleico
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
Poluentes do Solo/metabolismo
Ubiquinona/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenites); 0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Industrial Waste); 0 (Metals); 0 (RNA, Ribosomal, 16S); 0 (Soil Pollutants); 1339-63-5 (Ubiquinone); I7T5V2W47R (Ubiquinone Q2); N5509X556J (arsenite)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.002157


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[PMID]:28843991
[Au] Autor:Li J; Zhao L; Zhang Y; Li W; Duan X; Chen J; Guo Y; Yang S; Sun G; Li B
[Ad] Endereço:Environment and Non-Communicable Disease Research Center, Key Laboratory of Arsenic-related Biological Effects and Prevention and Treatment in Liaoning Province, School of Public Health, China Medical University, Shenyang 110122, China; Department of Occupational and Environmental Health, Key Labora
[Ti] Título:Imbalanced immune responses involving inflammatory molecules and immune-related pathways in the lung of acute and subchronic arsenic-exposed mice.
[So] Source:Environ Res;159:381-393, 2017 11.
[Is] ISSN:1096-0953
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Inorganic arsenic has been claimed to increase the risk of pulmonary diseases through ingestion, as opposed to inhalation, which makes it a unique and intriguing environmental toxicant. However, the immunotoxic effects of lung, one of the targets of arsenic exposure, have not been extensively investigated in vivo. In the present study, we first confirmed that 2.5, 5 and 10mg/kg NaAsO orally for 24h dose-dependently triggered the infiltration of neutrophils, lymphocytes and macrophages in BALF. Not only the transcription activity, but also the secretion of proinflammatory cytokines IL-1ß, IL-6 and TNF-α were consistently raised in the lung and BALF of acute arsenic-exposed mice. Acute oral administration of NaAsO also raised pulmonary MPO activity and mRNA levels of chemokine Mip-2 and Mcp-1. Meanwhile, obvious histopathological damages with inflammatory cells infiltration and erythrocyte aggregation around the capillaries were verified in the lung of mice drank arsenic-rich water freely for 3 months. Furthermore, we affirmed notable disturbance of CD4 T-cell differentiation in the lung of acute arsenic-exposed mice, as demonstrated by up-regulated mRNA levels of regulator Gata3 and cytokine Il-4 of Th2, enhanced Foxp3 and Il-10 of Treg, down-regulated T-bet and Ifn-γ of Th1, as well as lessened Ror-γt and Il-23 of Th17. However, impressive elevation of cytokine Ifn-γ and Il-23, as well as moderate enhancement of Il-4 and Il-10 were found in the lung by subchronic arsenic administration. Finally, our present study demonstrated that both a single and sustained arsenic exposure prominently increased the expression of immune-related p38, JNK, ERK1/2 and NF-κB proteins in the lung tissue. While disrupting the pulmonary redox homeostasis by increasing MDA levels, exhausting GSH and impaired enzyme activities of CAT and GSH-Px, antioxidant regulator NRF2 and its downstream targets HO-1 and GSTO1/2 were also up-regulated by both acute and subchronic arsenic treatment. Conclusively, our present study demonstrated both acute and subchronic oral administration of arsenic triggers multiple pulmonary immune responses involving inflammatory molecules and T-cell differentiation, which might be closely associated with the imbalanced redox status and activation of immune-related MAPKs, NF-κB and anti-inflammatory NRF2 pathways.
[Mh] Termos MeSH primário: Arsênico/toxicidade
Arsenitos/toxicidade
Poluentes Ambientais/toxicidade
Compostos de Sódio/toxicidade
[Mh] Termos MeSH secundário: Animais
Líquido da Lavagem Broncoalveolar/imunologia
Linfócitos T CD4-Positivos/efeitos dos fármacos
Linfócitos T CD4-Positivos/imunologia
Diferenciação Celular/efeitos dos fármacos
Citocinas/efeitos dos fármacos
Citocinas/imunologia
Relação Dose-Resposta a Droga
Feminino
Pulmão/efeitos dos fármacos
Pulmão/imunologia
Camundongos
Camundongos Endogâmicos C57BL
Estresse Oxidativo/efeitos dos fármacos
Transdução de Sinais/efeitos dos fármacos
Testes de Toxicidade Aguda
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Arsenites); 0 (Cytokines); 0 (Environmental Pollutants); 0 (Sodium Compounds); 48OVY2OC72 (sodium arsenite); N712M78A8G (Arsenic)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170828
[St] Status:MEDLINE



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