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Pesquisa : D01.103.075 [Categoria DeCS]
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[PMID]:29381987
[Au] Autor:Yan GW; Deng JF; Bhetuwal A; Yang GQ; Fu QS; Chen H; Hu N; Zeng H; Fan XP; Yan GW; Wu XL
[Ad] Endereço:Department of Radiology, Suining Central Hospital, Suining.
[Ti] Título:A case report and literature review of barium sulphate aspiration during upper gastrointestinal examination.
[So] Source:Medicine (Baltimore);96(47):e8821, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Even though barium sulphate aspiration during upper gastrointestinal examination is a well-known phenomenon, complication such as long-term lung injury and death may still occur. This may depend upon the concentration, amount, anatomy, or certain predisposing factors. PATIENT CONCERNS: A 47-year-old woman who had a barium swallow to screen for foreign body in esophagus. DIAGNOSES: Chest radiographs demonstrated massive barium sulphate depositions in her trachea and inferior lobe of right lung. INTERVENTIONS: A chest x-ray was done that revealed massive barium sulphate depositions in her trachea and lower lobe of right lung. As the patient did not have further complaints, she requested a transfer to West China Hospital of Sichuan University, the hospital being near her residence, for further treatment. She eventually recovered and was discharged after 1 week. OUTCOMES: There were 23 articles (22 English and 1 Chinese with 17 men and 11 women) included in the study. The risk factors of barium sulphate aspiration are dysphagia (10/28, 35.71%) followed by esophageal obstruction caused by tumor (5/28, 17.86%) and foreign body in esophagus (3/28, 10.71%). Infants (5/28, 17.86%) are also one of the high-risk population. Both the lungs were affected in most of the patients (21/28, 75%). Majority of the presentation in patients (21/28, 75%) were dyspnea, hypoxemia, acute respiratory distress syndrome (ARDS), or respiratory failure. Few patients (7/28, 25%) showed no symptoms or mild symptoms such as cough and fever. Barium sulphate aspiration can be life-threatening with a high risk of death (nearly 40%). LESSONS: When performing an upper gastrointestinal examination with barium sulphate, careful consideration of concentration and amount of barium sulphate and that of risk factors should be undertaken so as to avoid life-threatening aspiration.
[Mh] Termos MeSH primário: Sulfato de Bário/efeitos adversos
Meios de Contraste/efeitos adversos
Endoscopia do Sistema Digestório/efeitos adversos
Esôfago/diagnóstico por imagem
Corpos Estranhos/diagnóstico por imagem
Aspiração Respiratória/induzido quimicamente
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
Radiografia
Traqueia/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Contrast Media); 25BB7EKE2E (Barium Sulfate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008821


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[PMID]:29277779
[Au] Autor:Kishimoto S; Aoki H; Suzuki R; Inoue M; Fukushima S
[Ad] Endereço:Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Japan skisimot@pharm.kobegakuin.ac.jp.
[Ti] Título:Angiographic Evaluation of Vascular Damage in Rat Liver After Administration of Epirubicin or Miriplatin.
[So] Source:Anticancer Res;38(1):247-251, 2018 01.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Maintaining the function of blood vessels is important for the control of hepatocellular carcinoma (HCC) during treatment with repeated transcatheter arterial chemoembolization (TACE). This study was designed to compare the vascular damage caused by miriplatin (MPT), which has been commonly used for TACE, with the damage caused by epirubicin (EPI). MATERIALS AND METHODS: We used the portal vein of healthy rats for the administration of the drug (MPT or EPI) and/or soybean oil as vehicle. After 2 days, angiography was performed by X-ray computer tomography. RESULTS: The influence of soybean oil on blood vessel function was volume-dependent. EPI showed dose-dependent effects on angiography, and 0.5 mg EPI led to severe (grade 4) blood flow disturbance in all animals. The effect of 1 mg MPT on blood vessels was mild (grade 1) in all animals and not different from that of soybean oil alone. CONCLUSION: Less vascular damage is caused by MPT than by EPI, suggesting that MPT is a useful drug for TACE in HCC.
[Mh] Termos MeSH primário: Antineoplásicos/efeitos adversos
Epirubicina/efeitos adversos
Fígado/efeitos dos fármacos
Compostos Organoplatínicos/efeitos adversos
[Mh] Termos MeSH secundário: Angiografia
Animais
Antineoplásicos/administração & dosagem
Sulfato de Bário/farmacologia
Quimioembolização Terapêutica
Epirubicina/administração & dosagem
Feminino
Seres Humanos
Fígado/irrigação sanguínea
Fígado/diagnóstico por imagem
Compostos Organoplatínicos/administração & dosagem
Ratos Sprague-Dawley
Óleo de Soja/administração & dosagem
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Organoplatinum Compounds); 25BB7EKE2E (Barium Sulfate); 3Z8479ZZ5X (Epirubicin); 780F0P8N4I (miriplatin); 8001-22-7 (Soybean Oil)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE


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[PMID]:28823340
[Au] Autor:Kim DB; Bowers S; Thomas M
[Ad] Endereço:Department of General Surgery, Mayo Clinic Florida, Jacksonville, Florida. Electronic address: Kim.daniel@mayo.edu.
[Ti] Título:Black and White Esophagus: Rare Presentations of Severe Esophageal Ischemia.
[So] Source:Semin Thorac Cardiovasc Surg;29(2):256-259, 2017 Summer.
[Is] ISSN:1532-9488
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Benign esophageal strictures are typically the result of long-standing gastroesophageal reflux, and are usually treated with serial dilations and acid-suppressive therapy. Other causes of benign esophageal strictures include external beam radiation, caustic ingestions, prior surgery, and external compression from mediastinal fibrosis. We report 2 rare causes of ischemic esophageal structuring occurring after operations unrelated to the esophagus. The first is a patient who developed esophageal injury following radiofrequency ablation for atrial fibrillation. The direct thermal injury resulted in a "white esophagus" with a full-thickness, long-segmental stricture. The second patient presented with a "black esophagus" also known as acute necrotizing esophagitis. This occurred after an orthotopic liver transplant, which was complicated by multiple organ dysfunction secondary to hemorrhagic shock. In this report, we present 2 rare causes of esophageal stricturing that occurred after procedures not necessarily related to the esophagus itself. Early recognition and active management of these esophageal injuries may lead to better outcomes.
[Mh] Termos MeSH primário: Fibrilação Atrial/cirurgia
Ablação por Cateter/efeitos adversos
Estenose Esofágica/patologia
Esofagite/patologia
Esôfago/irrigação sanguínea
Esôfago/patologia
Isquemia/patologia
Transplante de Fígado/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Sulfato de Bário/administração & dosagem
Meios de Contraste/administração & dosagem
Estenose Esofágica/etiologia
Estenose Esofágica/cirurgia
Esofagectomia/métodos
Esofagite/etiologia
Esofagite/cirurgia
Esofagoscopia
Esôfago/lesões
Esôfago/cirurgia
Feminino
Seres Humanos
Isquemia/etiologia
Isquemia/cirurgia
Laparoscopia
Masculino
Meia-Idade
Necrose
Toracoscopia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 25BB7EKE2E (Barium Sulfate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170822
[St] Status:MEDLINE


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[PMID]:28732010
[Au] Autor:Carrel M; Beltran MA; Morales VL; Derlon N; Morgenroth E; Kaufmann R; Holzner M
[Ad] Endereço:Institute of Environmental Engineering, ETH Zürich, Stefano Franscini-Platz 5, 8093 Zurich, Switzerland.
[Ti] Título:Biofilm imaging in porous media by laboratory X-Ray tomography: Combining a non-destructive contrast agent with propagation-based phase-contrast imaging tools.
[So] Source:PLoS One;12(7):e0180374, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:X-ray tomography is a powerful tool giving access to the morphology of biofilms, in 3D porous media, at the mesoscale. Due to the high water content of biofilms, the attenuation coefficient of biofilms and water are very close, hindering the distinction between biofilms and water without the use of contrast agents. Until now, the use of contrast agents such as barium sulfate, silver-coated micro-particles or 1-chloronaphtalene added to the liquid phase allowed imaging the biofilm 3D morphology. However, these contrast agents are not passive and potentially interact with the biofilm when injected into the sample. Here, we use a natural inorganic compound, namely iron sulfate, as a contrast agent progressively bounded in dilute or colloidal form into the EPS matrix during biofilm growth. By combining a very long source-to-detector distance on a X-ray laboratory source with a Lorentzian filter implemented prior to tomographic reconstruction, we substantially increase the contrast between the biofilm and the surrounding liquid, which allows revealing the 3D biofilm morphology. A comparison of this new method with the method proposed by Davit et al (Davit et al., 2011), which uses barium sulfate as a contrast agent to mark the liquid phase was performed. Quantitative evaluations between the methods revealed substantial differences for the volumetric fractions obtained from both methods. Namely, contrast agent-biofilm interactions (e.g. biofilm detachment) occurring during barium sulfate injection caused a reduction of the biofilm volumetric fraction of more than 50% and displacement of biofilm patches elsewhere in the column. Two key advantages of the newly proposed method are that passive addition of iron sulfate maintains the integrity of the biofilm prior to imaging, and that the biofilm itself is marked by the contrast agent, rather than the liquid phase as in other available methods. The iron sulfate method presented can be applied to understand biofilm development and bioclogging mechanisms in porous materials and the obtained biofilm morphology could be an ideal basis for 3D numerical calculations of hydrodynamic conditions to investigate biofilm-flow coupling.
[Mh] Termos MeSH primário: Biofilmes
Tomografia por Raios X/métodos
[Mh] Termos MeSH secundário: Sulfato de Bário
Meios de Contraste
Compostos Ferrosos
Polímeros de Fluorcarboneto
Imagem Tridimensional/métodos
Porosidade
Reologia
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (Ferrous Compounds); 0 (Fluorocarbon Polymers); 059QF0KO0R (Water); 25BB7EKE2E (Barium Sulfate); 39464-59-0 (perfluorosulfonic acid); 39R4TAN1VT (ferrous sulfate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180374


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[PMID]:28647230
[Au] Autor:Xu T; Wu X; Liu X; Cao L; Lin Q; Weng D
[Ad] Endereço:Key Laboratory of Advanced Materials of Ministry of Education, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China. Electronic address: xtf14@mails.tsinghua.edu.cn.
[Ti] Título:Effect of barium sulfate modification on the SO tolerance of V O /TiO catalyst for NH -SCR reaction.
[So] Source:J Environ Sci (China);57:110-117, 2017 Jul.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Sulfur poisoning of V O /BaSO -TiO (VBT), V O /WO -TiO (VWT) and V O /BaSO -WO -TiO (VBWT) catalysts was performed in wet air at 350°C for 3hr, and activities for the selective catalytic reduction of NO with NH were evaluated for 200-500°C. The VBT catalyst showed higher NO conversions after sulfur poisoning than the other two catalysts. The introduction of barium sulfate contributed to strong acid sites for the as-received catalyst, and eliminated the redox cycle of active vanadium oxide to some extent, which resulted in a certain loss of activity. Readily decomposable sulfate species formed on VBT-S instead of inactive sulfates on VWT-S. These decomposable sulfates increased the number of strong acid sites significantly. Some sulfate species escaped during catalyst preparation and barium sulfate was reproduced during sulfur poisoning, which protects vanadia from sulfur oxide attachment to a great extent. Consequently, the VBT catalyst exhibited the best resistance to sulfur poisoning.
[Mh] Termos MeSH primário: Sulfato de Bário/química
Modelos Químicos
Dióxido de Enxofre/química
Titânio/química
Compostos de Vanádio/química
[Mh] Termos MeSH secundário: Catálise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vanadium Compounds); 0UZA3422Q4 (Sulfur Dioxide); 15FIX9V2JP (titanium dioxide); 25BB7EKE2E (Barium Sulfate); BVG363OH7A (vanadium pentoxide); D1JT611TNE (Titanium)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170626
[St] Status:MEDLINE


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[PMID]:28483848
[Au] Autor:Zaheen A; Stanbrook MB
[Ad] Endereço:Department of Medicine (Zaheen), University of Toronto; Division of Respirology (Stanbrook), Toronto Western Hospital, Toronto, Ont.
[Ti] Título:Accidental barium bronchography.
[So] Source:CMAJ;189(18):E670, 2017 05 08.
[Is] ISSN:1488-2329
[Cp] País de publicação:Canada
[La] Idioma:eng
[Mh] Termos MeSH primário: Sulfato de Bário/efeitos adversos
Broncografia/efeitos adversos
Pneumonia Aspirativa/etiologia
[Mh] Termos MeSH secundário: Carcinoma de Células Escamosas
Seres Humanos
Masculino
Meia-Idade
Pneumonia Aspirativa/diagnóstico por imagem
Neoplasias Tonsilares
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
25BB7EKE2E (Barium Sulfate)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.160969


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[PMID]:28444619
[Au] Autor:Schyma C; Bauer K; Brünig J
[Ad] Endereço:Institute of Forensic Medicine, University of Bern, Bühlstrasse 20, CH-3012, Bern, Switzerland. christian.schyma@irm.unibe.ch.
[Ti] Título:The reference cube: A new ballistic model to generate staining in firearm barrels.
[So] Source:Forensic Sci Med Pathol;13(2):188-195, 2017 Jun.
[Is] ISSN:1556-2891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:After contact shots to the head biological traces can be found inside firearm barrels. So far silicone coated, gelatin filled box models were used to generate such staining according to the triple contrast method (mixture of acrylic paint, barium sulfate and blood sealed in a thin foil bag). This study was conducted to develop a transparent ballistic model allowing contact shots. Gelatin filled polyethylene bottles with and without a silicone coat were tested in comparison to non-covered gelatin blocks. Finally, thin foil bags of 5 cm × 5 cm dimension were glued on a synthetic absorbent kitchen wipe on top of which 1 L 10% gelatin solution was molded to create blocks of 8.5 cm length. A kitchen wipe with a paint pad on its inside formed the front of the cube. Three contact shots each with a 9 mm Luger pistol and a .38 special revolver were performed on all model variations. The staining was documented by endoscopy and swabs gathered from both ends of the barrel were analyzed by quantitative PCR. Reliable staining was achieved using the front covered gelatin block with comparable results to the silicone coated box model used before. For further research using ballistic models to simulate a human head a symmetric form of the gelatin block such as a cube is recommended.
[Mh] Termos MeSH primário: Armas de Fogo
Balística Forense/métodos
Modelos Biológicos
Ferimentos por Arma de Fogo
[Mh] Termos MeSH secundário: Sulfato de Bário
Meios de Contraste
DNA/isolamento & purificação
Impressões Digitais de DNA
Gelatina
Seres Humanos
Repetições de Microssatélites
Reação em Cadeia da Polimerase
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 25BB7EKE2E (Barium Sulfate); 9000-70-8 (Gelatin); 9007-49-2 (DNA)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1007/s12024-017-9868-3


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[PMID]:28432887
[Au] Autor:Falciglia PP; Romano S; Vagliasindi FGA
[Ad] Endereço:Department of Civil Engineering and Architecture, University of Catania, Viale A. Doria, 6, 95125 Catania, Italy; Laboratori Nazionali del Sud - INFN, Via S. Sofia, 62, 95125 Catania, Italy. Electronic address: ppfalci@dica.unict.it.
[Ti] Título:Application of a γRS index-based method and techno-economic analysis for in situ treatment of Cs-contaminated soils by cement-barite based stabilisation/solidification.
[So] Source:J Environ Manage;197:619-630, 2017 Jul 15.
[Is] ISSN:1095-8630
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This paper examines the application of cement (C)-barite (Ba) based-Stabilisation/Solidification (S/S) for the remediation of Cs-contaminated soils, investigating the influence of soil: grout and C: Ba ratios on the shielding performance of the S/S mix assessed as gamma radiation shielding (γRS) index variation. Results from experiments were used to perform a novel approach and an economic analysis in order to calculate the effective dose reduction achievable by S/S and to assess the optimum quantities and costs of selected mixes, respectively. Gamma ray spectrometer measurements indicate that γRS index increases with increasing barite percentage up to a maximum level of 50%; however a further increase results in a worsening of the shielding performances. A maximum γRS variation of 46.5% was recorded with grout percentage increasing from 16.6 to 50%. At the photon energy of 662 keV ( Cs), the maximum grout amount results in the possibility to shield up to 24.1% of γ-rays emitted. The effective dose reduction achievable by the investigated S/S allows a maximum Cs-soil contamination in the range 2.94-14.55 kBq kg successfully treatable employing a soil: grout ratio of 1: 1 (C: Ba = 1:1). Technical data, jointly with economic analysis findings, make cement-barite based-S/S very competitive in cost-effectiveness and could provide a basis for decision-making of Cs-contaminated site remediation.
[Mh] Termos MeSH primário: Radioisótopos de Césio
Recuperação e Remediação Ambiental
Raios gama
Poluentes Radioativos do Solo
[Mh] Termos MeSH secundário: Sulfato de Bário
Poluição Ambiental
Solo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cesium Radioisotopes); 0 (Soil); 0 (Soil Pollutants, Radioactive); 25BB7EKE2E (Barium Sulfate)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170423
[St] Status:MEDLINE


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[PMID]:28293625
[Au] Autor:Xia Q; Feng Y; Yin T; Liu Y; Zhang G; Liu J; Tong L; Willemyns R; Yu J; Oyen R; Huang G; Ni Y
[Ad] Endereço:Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pu Jian Road, Shanghai 200127, China; Department of Imaging and Pathology, University Hospitals, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
[Ti] Título:An Imaging and Histological Study on Intrahepatic Microvascular Passage of Contrast Materials in Rat Liver.
[So] Source:Biomed Res Int;2017:1419545, 2017.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:. Lipiodol has been applied for decades in transarterial chemoembolization to treat liver malignancies, but its intrahepatic pathway through arterioportal shunt (APS) in the liver has not been histologically revealed. This rodent experiment was conducted to provide evidence for the pathway of Lipiodol delivered through the hepatic artery (HA) but found in the portal vein (PV) and to elucidate the observed unidirectional APS. . Thirty rats were divided into 5 groups receiving systemic or local arterial infusion of red-stained iodized oil (RIO) or its hydrosoluble substitute barium sulfate suspension (BSS), or infusion of BSS via the PV, monitored by real-time digital radiography. Histomorphology of serial frozen and paraffin sections was performed and quantified. . After HA infusion, RIO and BSS appeared extensively in PV lumens with peribiliary vascular plexus (PVP) identified as the responsible anastomotic channel. After PV infusion, BSS appeared predominantly in the PV and surrounding sinusoids and to a much lesser extent in the PVP and HA ( < 0.001). Fluid mechanics well explains the one-way-valve phenomenon of APS. . Intravascularly injected rat livers provide histomorphologic evidences: (1) the PVP exists in between the HA and PV, which is responsible to the APS of Lipiodol; and (2) the intrahepatic vascular inflow appears HA-PVP-PV unidirectional without a physical one-way valve, which can be postulated by the fluid mechanics.
[Mh] Termos MeSH primário: Fígado/irrigação sanguínea
Fígado/diagnóstico por imagem
Microcirculação
[Mh] Termos MeSH secundário: Angiografia
Animais
Sulfato de Bário/química
Fenômenos Biomecânicos
Meios de Contraste/química
Óleo Etiodado/química
Feminino
Artéria Hepática/diagnóstico por imagem
Óleo Iodado/química
Masculino
Modelos Teóricos
Veia Porta/diagnóstico por imagem
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 25BB7EKE2E (Barium Sulfate); 8001-40-9 (Iodized Oil); 8008-53-5 (Ethiodized Oil)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1155/2017/1419545


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[PMID]:28285706
[Au] Autor:Hwang TJ; Servaes S; Mattei P; Anupindi SA
[Ad] Endereço:Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address: tiffanyhwang@gmail.com.
[Ti] Título:Radiologist performance in the interpretation of contrast enemas performed for Hirschsprung's disease in children >1 year of age.
[So] Source:Clin Radiol;72(6):519.e11-519.e19, 2017 Jun.
[Is] ISSN:1365-229X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: To evaluate the diagnostic performance of contrast enemas (CEs) for the diagnosis of Hirschsprung's disease (HD). METHODS AND MATERIALS: CE studies performed as part of an HD workup in patients 1-18 years of age over a 10-year period were identified. All abnormal CE studies and an equal number of age-matched controls were included in the final study group. Two radiologists independently and blindly reviewed all CE studies for quality (scale of 0-3) and the presence of large colon calibre, colon redundancy, transition zone, rectosigmoid ratio, and abnormal contractions. Readers also determined whether a rectal biopsy would be recommended to confirm an HD diagnosis. Discrepancies were resolved in consensus. Findings were correlated with surgery and biopsy data. RESULTS: Out of 834 CE studies, 38 abnormal CE studies were identified (mean age 5.9 years) and included 38 matched controls. Seventeen of 76 patients were recommended for rectal biopsy, of which five were confirmed to have HD. Twelve of 70 (17.1%) were false positives, and were clinically confirmed not to have HD. The proportion of HD in the present population was 6/834 (0.72%). Of the 17 recommended for biopsy, CE studies showed 17/17 (100%) with an abnormal rectosigmoid ratio, 16/17 (94.1%) with redundant colon, and 15/17 (88%) with large colon. Of patients not recommended for biopsy, one was diagnosed with HD, (false negative, 16.7%). The diagnostic performance of CE was 83.3% sensitivity and 82.9% specificity. CONCLUSION: Few children >1 year of age were found to have HD and the diagnostic performance of the CE is moderately high. The CE examination is a valuable non-invasive imaging study to help exclude older children who may not have HD, thereby obviating the need for invasive rectal biopsy and surgery.
[Mh] Termos MeSH primário: Sulfato de Bário
Competência Clínica
Meios de Contraste
Enema
Doença de Hirschsprung/diagnóstico por imagem
Radiografia Abdominal
Radiologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 25BB7EKE2E (Barium Sulfate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE



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