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[PMID]: 29292944 [Au] Autor: Bradley M; Wahlgren CF [Ad] Endereço: Institutionen för Medicin - Hudkliniken, Karolinska i Solna Stockholm, Sweden Institutionen för Medicin - Department of dermatology Stockholm, Sweden. [Ti] Título: Nya läkemedel mot atopiskt eksem väntar på godkännande - Bättre förståelse av den molekylära sjukdomsmekanismen kan ge fler och bättre verktyg för behandling.. [So] Source: Lakartidningen;114, 2017 Nov 21. [Is] ISSN: 1652-7518 [Cp] País de publicação: Sweden [La] Idioma: swe [Ab] Resumo: New treatments for atopic dermatitis Atopic dermatitis is one of the most common skin disorders in Sweden. The pathogenesis is a complex counterplay between a defect skin barrier and an abnormal immune response that can be caused by genetic and/or environmental factors. Atopic dermatitis has a huge negative impact on quality of life. New and more specific treatments are under way and hopefully we will, in the near future, better treat even the more severe cases of atopic dermatitis. [Mh] Termos MeSH primário: Dermatite Atópica/tratamento farmacológico Fármacos Dermatológicos/uso terapêutico [Mh] Termos MeSH secundário: Anticorpos Monoclonais/uso terapêutico Compostos de Boro/uso terapêutico Compostos Bicíclicos Heterocíclicos com Pontes/uso terapêutico Dermatite Atópica/metabolismo Dermatite Atópica/fisiopatologia Aprovação de Drogas Emolientes/uso terapêutico Seres Humanos Pele/metabolismo Pele/fisiopatologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antibodies, Monoclonal); 0 (Boron Compounds); 0 (Bridged Bicyclo Compounds, Heterocyclic); 0 (Dermatologic Agents); 0 (Emollients) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180306 [Lr] Data última revisão: 180306 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180103 [St] Status: MEDLINE

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[PMID]: 28742061 [Au] Autor: Poppinga D; Halbur J; Lemmer S; Delfs B; Harder D; Looe HK; Poppe B [Ad] Endereço: University Clinic for Medical Radiation Physics, Medical Campus Pius-Hospital, Carl von Ossietzky University, Oldenburg, Germany. [Ti] Título: Test study of boron nitride as a new detector material for dosimetry in high-energy photon beams. [So] Source: Phys Med Biol;62(18):N436-N444, 2017 Sep 05. [Is] ISSN: 1361-6560 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The aim of this test study is to check whether boron nitride (BN) might be applied as a detector material in high-energy photon-beam dosimetry. Boron nitride exists in various crystalline forms. Hexagonal boron nitride (h-BN) possesses high mobility of the electrons and holes as well as a high volume resistivity, so that ionizing radiation in the clinical range of the dose rate can be expected to produce a measurable electrical current at low background current. Due to the low atomic numbers of its constituents, its density (2.0 g cm ) similar to silicon and its commercial availability, h-BN appears as possibly suitable for the dosimetry of ionizing radiation. Five h-BN plates were contacted to triaxial cables, and the detector current was measured in a solid-state ionization chamber circuit at an applied voltage of 50 V. Basic dosimetric properties such as formation by pre-irradiation, sensitivity, reproducibility, linearity and temporal resolution were measured with 6 MV photon irradiation. Depth dose curves at quadratic field sizes of 10 cm and 40 cm were measured and compared to ionization chamber measurements. After a pre-irradiation with 6 Gy, the devices show a stable current signal at a given dose rate. The current-voltage characteristic up to 400 V shows an increase in the collection efficiency with the voltage. The time-resolved detector current behavior during beam interrupts is comparable to diamond material, and the background current is negligible. The measured percentage depth dose curves at 10 cm × 10 cm field size agreed with the results of ionization chamber measurements within ±2%. This is a first study of boron nitride as a detector material for high-energy photon radiation. By current measurements on solid ionization chambers made from boron nitride chips we could demonstrate that boron nitride is in principle suitable as a detector material for high-energy photon-beam dosimetry. [Mh] Termos MeSH primário: Compostos de Boro/química Teste de Materiais Fótons/uso terapêutico Radiometria/instrumentação Radiometria/métodos Radioterapia de Alta Energia/instrumentação [Mh] Termos MeSH secundário: Diamante/química Elétrons Reprodutibilidade dos Testes Silício/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Boron Compounds); 2U4T60A6YD (boron nitride); 7782-40-3 (Diamond); Z4152N8IUI (Silicon) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170726 [St] Status: MEDLINE [do] DOI: 10.1088/1361-6560/aa81f7

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[PMID]: 29289888 [Au] Autor: Durantini AM; Heredia DA; Durantini JE; Durantini EN [Ad] Endereço: Departamento de Química, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Ruta Nacional 36 Km 601, X5804BYA Río Cuarto, Córdoba, Argentina. [Ti] Título: BODIPYs to the rescue: Potential applications in photodynamic inactivation. [So] Source: Eur J Med Chem;144:651-661, 2018 Jan 20. [Is] ISSN: 1768-3254 [Cp] País de publicação: France [La] Idioma: eng [Ab] Resumo: 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) derivatives have been proposed in several potential biomedical applications. BODIPYs absorb strongly in blue-green region with high fluorescence emission, properties that convert them in effective fluorophores in the field of biological labeling. However, BODIPY structures can be conveniently modified by heavy atoms substitution to obtain photosensitizers with applications in photodynamic therapy. Also, external heavy atoms effect can be used to increase the photodynamic activity of these compounds. In recent years, BODIPYs have been proposed as phototherapeutic agents for the photodynamic inactivation of microorganisms. Therefore, BODIPY structures need to be optimized to produce an efficient photocytotoxic activity. In this way, amphiphilic cationic BODIPYs can selectively bind to microbial cells, inducing an effective photokilling of pathogenic microbial cells. This review summarizes the attributes of BODIPY derivatives for applications as antimicrobial photosensitizing agents. [Mh] Termos MeSH primário: Compostos de Boro/química Corantes Fluorescentes/química Fotoquimioterapia Fármacos Fotossensibilizantes/química [Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga Seres Humanos Estrutura Molecular Relação Estrutura-Atividade [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene); 0 (Boron Compounds); 0 (Fluorescent Dyes); 0 (Photosensitizing Agents) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180302 [Lr] Data última revisão: 180302 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180101 [St] Status: MEDLINE

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[PMID]: 29472470 [Au] Autor: Broere DLJ; Holland PL [Ad] Endereço: Debye Institute for Nanomaterials Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, Netherlands. d.l.j.broere@uu.nl patrick.holland@yale.edu. [Ti] Título: Boron compounds tackle dinitrogen. [So] Source: Science;359(6378):871, 2018 02 23. [Is] ISSN: 1095-9203 [Cp] País de publicação: United States [La] Idioma: eng [Mh] Termos MeSH primário: Amônia Molibdênio [Mh] Termos MeSH secundário: Boro Compostos de Boro [Pt] Tipo de publicação: JOURNAL ARTICLE; COMMENT [Nm] Nome de substância: 0 (Boron Compounds); 7664-41-7 (Ammonia); 81AH48963U (Molybdenum); N9E3X5056Q (Boron) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180227 [Lr] Data última revisão: 180227 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180224 [St] Status: MEDLINE [do] DOI: 10.1126/science.aar7395

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[PMID]: 29254896 [Au] Autor: Bizet F; Ipuy M; Bernhard Y; Lioret V; Winckler P; Goze C; Perrier-Cornet JM; Decréau RA [Ad] Endereço: ICMUB Institute, University Bourgogne - Franche Comté, 9 Avenue Alain Savary, Sciences Mirande, 21078 Dijon, France. [Ti] Título: Cellular imaging using BODIPY-, pyrene- and phthalocyanine-based conjugates. [So] Source: Bioorg Med Chem;26(2):413-420, 2018 01 15. [Is] ISSN: 1464-3391 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Fluorescent Probes aimed at absorbing in the blue/green region of the spectrum and emitting in the green/red have been synthesized (as the form of dyads-pentads), studied by spectrofluorimetry, and used for cellular imaging. The synthesis of phthalocyanine-pyrene 1 was achieved by cyclotetramerization of pyrenyldicyanobenzene, whereas phthalocyanine-BODIPY 2c was synthesized by Sonogashira coupling between tetraiodophthalocyanine and meso-alkynylBODIPY. The standard four-steps BODIPY synthesis was applied to the BODIPY-pyrene dyad 3 starting from pyrenecarbaldehyde and dimethylpyrrole. H, C, F, BNMR, ICP, MS, and UV/Vis spectroscopic analyses demonstrated that 2c is a mixture of BODIPY-Pc conjugates corresponding to an average ratio of 2.5 BODIPY per Pc unit, where its bis, tris, tetrakis components could not be separated. Fluorescence emission studies (µM concentration in THF) showed that the design of the probes allowed excitation of their antenna (pyrene, BODIPY) in the blue/green region of the spectrum, and subsequent transfer to the acceptor platform (BODIPY, phthalocyanine) followed by its emission in the green/red (with up to 140-350 nm overall Stokes shifts). The fluorescent probes were used for cellular imaging of B16F10 melanoma cells upon solubilization in 1% DMSO containing RPMI or upon encapsulation in liposomes (injection method). Probes were used at 1-10 µM concentrations, cells were fixed with methanol and imaged by biphoton and/or confocal microscopy, showing that probes could achieve the staining of cells membranes and not the nucleus. [Mh] Termos MeSH primário: Compostos de Boro/química Corantes Fluorescentes/química Indóis/química Melanoma/diagnóstico Pirenos/química [Mh] Termos MeSH secundário: Animais Corantes Fluorescentes/síntese química Camundongos Estrutura Molecular Células Tumorais Cultivadas [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene); 0 (Boron Compounds); 0 (Fluorescent Dyes); 0 (Indoles); 0 (Pyrenes); 9E0T7WFW93 (pyrene); V5PUF4VLGY (phthalocyanine) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171220 [St] Status: MEDLINE

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[PMID]: 29232571 [Au] Autor: Gawale Y; Sekar N [Ad] Endereço: Department of Dyestuff Technology, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga, Mumbai 400 019, India. [Ti] Título: Investigating the excited state optical properties and origin of large stokes shift in Benz[c,d]indole N-Heteroarene BF dyes with ab initio tools. [So] Source: J Photochem Photobiol B;178:472-480, 2018 Jan. [Is] ISSN: 1873-2682 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: Density Functional Theory and Time Dependent Density Functional Theory computations reveal experimental trends accurately and provide an insight into the origin of red shifted optical spectra, large Stokes shift, nonlinear optical responses and quantitative description of the singlet-triplet energy gap of recently synthesized highly fluorescent membrane permeable benz[c,d]indole N-heteroarene BF rigidified BBN and BBC dyes. Our results benchmark the importance of the DFT functionals and polarization functions using the accurate basis set for the calculations of excitation energies, band gaps, dipole moment, non-linear optical properties and geometrical parameters. The anomalous increase in dipole moment in the excited state and pronounced geometric distortion are found to be responsible for the increased Stokes shift in BBN dyes. The resultant decrease in the HOMO-LUMO energy gap was found to be responsible for the red shift in BBC dyes. Enhanced nonlinear optical properties and inverse relationship between the Stokes shift and static hyperpolarizability were found in these dyes. Their possible potential therapeutic use as a photosensitizer in photodynamic therapy is proposed on the basis of vertical triplet energies resulting in the range of 0.78 to 0.88eV. The singlet-triplet energetic gaps suggest that the simple variation of the N-heteroarenes or their post functionalization can lead to the efficient generation of singlet oxygen. Further, we compared these new class of dyes with conventional aza-BODIPY and BODIPY dyes, thereby confirming their use as alternative promising candidates for nonlinear optics, triplet sensitizers, and imaging. [Mh] Termos MeSH primário: Corantes Fluorescentes/química Indóis/química [Mh] Termos MeSH secundário: Compostos de Boro/química Fármacos Fotossensibilizantes/química Teoria Quântica [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Boron Compounds); 0 (Fluorescent Dyes); 0 (Indoles); 0 (Photosensitizing Agents); 0 (azaBDPBA compound) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180212 [Lr] Data última revisão: 180212 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171213 [St] Status: MEDLINE

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[PMID]: 27774548 [Au] Autor: Shi WJ; Lo PC; Zhao S; Wong RC; Wang Q; Fong WP; Ng DK [Ad] Endereço: Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. dkpn@cuhk.edu.hk. [Ti] Título: A biotin-conjugated glutathione-responsive FRET-based fluorescent probe with a ferrocenyl BODIPY as the dark quencher. [So] Source: Dalton Trans;45(44):17798-17806, 2016 Nov 28. [Is] ISSN: 1477-9234 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: An efficient ferrocenyl BODIPY based dark quencher has been developed and employed to construct a FRET-based fluorescent probe that contains a biotin moiety as a potential directing ligand for cancer cells and a glutathione-cleavable disulfide linker connecting the quencher and a distyryl BODIPY fluorophore. This molecular probe is deactivated in the native form through FRET followed by intramolecular charge transfer due to the ferrocenyl unit. However, upon interaction with glutathione in phosphate buffered saline and inside cancer cells, the fluorescence emission is significantly increased due to detachment of the fluorophore from the quencher. As shown by flow cytometry, this probe also exhibits preferential uptake by the biotin-receptor-expressing A549 human lung adenocarcinoma epithelial cells over the Chinese hamster ovary CHO-K1 cells used as the negative control. On the basis that both biotin receptor and GSH level are often overexpressed or elevated in cancer cells, this dual functional fluorescent probe serves as a promising agent for cancer imaging. [Mh] Termos MeSH primário: Biotina/química Compostos de Boro/química Corantes Fluorescentes/química Glutationa/análise [Mh] Termos MeSH secundário: Células A549 Animais Células CHO Cricetulus Compostos Ferrosos/química Transferência Ressonante de Energia de Fluorescência Seres Humanos Neoplasias/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene); 0 (Boron Compounds); 0 (Ferrous Compounds); 0 (Fluorescent Dyes); 6SO6U10H04 (Biotin); GAN16C9B8O (Glutathione) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180131 [Lr] Data última revisão: 180131 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161025 [St] Status: MEDLINE

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[PMID]: 29256506 [Au] Autor: Lee J; Radomkit S; Torker S; Del Pozo J; Hoveyda AH [Ad] Endereço: Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA. [Ti] Título: Mechanism-based enhancement of scope and enantioselectivity for reactions involving a copper-substituted stereogenic carbon centre. [So] Source: Nat Chem;10(1):99-108, 2018 01. [Is] ISSN: 1755-4349 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: A rapidly emerging set of catalytic reactions involves intermediates that contain a copper-substituted stereogenic carbon centre. Here, we demonstrate that an intimate understanding of this distinction provides ways for addressing limitations in reaction scope and explaining why unexpected variations in enantioselectivity often occur. By using catalytic enantioselective Cu-boryl addition to alkenes as the model process, we elucidate several key mechanistic principles. We show that higher electrophile concentration can lead to elevated enantioselectivity. This is because diastereoselective Cu-H elimination may be avoided and/or achiral Cu-boryl intermediates can be converted to allyl-B(pin) rather than add to an alkene. We illustrate that lower alkene amounts and/or higher chiral ligand concentration can minimize the deleterious influence of achiral Cu-alkyl species, resulting in improved enantiomeric ratios. Moreover, and surprisingly, we find that enantioselectivities are higher with the less reactive allylphenyl carbonates as chemoselective copper-hydride elimination is faster with an achiral Cu-alkyl species. [Mh] Termos MeSH primário: Alcenos/química Compostos de Boro/química Cobre/química Compostos Organometálicos/química [Mh] Termos MeSH secundário: Catálise Técnicas de Química Sintética Modelos Químicos Estereoisomerismo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S. [Nm] Nome de substância: 0 (Alkenes); 0 (Boron Compounds); 0 (Organometallic Compounds); 789U1901C5 (Copper) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180123 [Lr] Data última revisão: 180123 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171220 [St] Status: MEDLINE [do] DOI: 10.1038/nchem.2861

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[PMID]: 29267336 [Au] Autor: Morihara H; Obana M; Tanaka S; Kawakatsu I; Tsuchiyama D; Mori S; Suizu H; Ishida A; Kimura R; Tsuchimochi I; Maeda M; Yoshimitsu T; Fujio Y; Nakayama H [Ad] Endereço: Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan. [Ti] Título: 2-aminoethoxydiphenyl borate provides an anti-oxidative effect and mediates cardioprotection during ischemia reperfusion in mice. [So] Source: PLoS One;12(12):e0189948, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Excessive levels of reactive oxygen species (ROS) and impaired Ca2+ homeostasis play central roles in the development of multiple cardiac pathologies, including cell death during ischemia-reperfusion (I/R) injury. In several organs, treatment with 2-aminoethoxydiphenyl borate (2-APB) was shown to have protective effects, generally believed to be due to Ca2+ channel inhibition. However, the mechanism of 2-APB-induced cardioprotection has not been fully investigated. Herein we investigated the protective effects of 2-APB treatment against cardiac pathogenesis and deciphered the underlying mechanisms. In neonatal rat cardiomyocytes, treatment with 2-APB was shown to prevent hydrogen peroxide (H2O2) -induced cell death by inhibiting the increase in intracellular Ca2+ levels. However, no 2-APB-sensitive channel blocker inhibited H2O2-induced cell death and a direct reaction between 2-APB and H2O2 was detected by 1H-NMR, suggesting that 2-APB chemically scavenges extracellular ROS and provides cytoprotection. In a mouse I/R model, treatment with 2-APB led to a considerable reduction in the infarct size after I/R, which was accompanied by the reduction in ROS levels and neutrophil infiltration, indicating that the anti-oxidative properties of 2-APB plays an important role in the prevention of I/R injury in vivo as well. Taken together, present results indicate that 2-APB treatment induces cardioprotection and prevents ROS-induced cardiomyocyte death, at least partially, by the direct scavenging of extracellular ROS. Therefore, administration of 2-APB may represent a promising therapeutic strategy for the treatment of ROS-related cardiac pathology including I/R injury. [Mh] Termos MeSH primário: Antioxidantes/farmacologia Compostos de Boro/farmacologia Traumatismo por Reperfusão/prevenção & controle [Mh] Termos MeSH secundário: Animais Camundongos Espécies Reativas de Oxigênio/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Antioxidants); 0 (Boron Compounds); 0 (Reactive Oxygen Species); E4ES684O93 (2-aminoethoxydiphenyl borate) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180116 [Lr] Data última revisão: 180116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171222 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0189948

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[PMID]: 29278948 [Au] Autor: Nocentini A; Cadoni R; Dumy P; Supuran CT; Winum JY [Ad] Endereço: a Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, ENSCM, Université de Montpellier , Montpellier Cedex , France. [Ti] Título: Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles. [So] Source: J Enzyme Inhib Med Chem;33(1):286-289, 2018 Dec. [Is] ISSN: 1475-6374 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: A series of 6-substituted ureido- and thioureido-benzoxaboroles were investigated as inhibitors of carbonic anhydrases from Trypanosoma cruzi (TcCA), and Leishmania donovani chagasi (LdcCA). Both enzymes were inhibited by benzoxaboroles in the micromolar range. Preferential inhibitory potency against the ß-CA LdcCA versus the α-CA TcCA was observed with submicromolar inhibitory activities. Some derivatives displayed excellent inhibitory and selectivity profile over the ubiquitous and physiological relevant human off-target hCA II. This study provides a convincing opportunity to study benzoxaborole scaffold for the design of antiprotozoan potential drugs targeting the pathogen's carbonic anhydrases. [Mh] Termos MeSH primário: Antiprotozoários/farmacologia Compostos de Boro/farmacologia Inibidores da Anidrase Carbônica/farmacologia Anidrases Carbônicas/metabolismo Compostos Heterocíclicos com 2 Anéis/farmacologia Leishmania donovani/efeitos dos fármacos Trypanosoma cruzi/efeitos dos fármacos [Mh] Termos MeSH secundário: Antiprotozoários/síntese química Antiprotozoários/química Compostos de Boro/síntese química Compostos de Boro/química Inibidores da Anidrase Carbônica/síntese química Inibidores da Anidrase Carbônica/química Relação Dose-Resposta a Droga Compostos Heterocíclicos com 2 Anéis/síntese química Compostos Heterocíclicos com 2 Anéis/química Leishmania donovani/enzimologia Testes de Sensibilidade Microbiana Estrutura Molecular Relação Estrutura-Atividade Trypanosoma cruzi/enzimologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antiprotozoal Agents); 0 (Boron Compounds); 0 (Carbonic Anhydrase Inhibitors); 0 (Heterocyclic Compounds, 2-Ring); EC 4.2.1.1 (Carbonic Anhydrases) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180105 [Lr] Data última revisão: 180105 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171228 [St] Status: MEDLINE [do] DOI: 10.1080/14756366.2017.1414808

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