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Pesquisa : D01.139 [Categoria DeCS]
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[PMID]:27332697
[Au] Autor:Zucconi BE; Luef B; Xu W; Henry RA; Nodelman IM; Bowman GD; Andrews AJ; Cole PA
[Ad] Endereço:Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine , Baltimore, Maryland 21205, United States.
[Ti] Título:Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain Ligand I-CBP112.
[So] Source:Biochemistry;55(27):3727-34, 2016 Jul 12.
[Is] ISSN:1520-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The histone acetyltransferase (HAT) enzymes p300 and CBP are closely related paralogs that serve as transcriptional coactivators and have been found to be dysregulated in cancer and other diseases. p300/CBP is a multidomain protein and possesses a highly conserved bromodomain that has been shown to bind acetylated Lys residues in both proteins and various small molecules, including I-CBP112 and CBP30. Here we show that the ligand I-CBP112 can stimulate nucleosome acetylation up to 3-fold while CBP30 does not. Activation of p300/CBP by I-CBP112 is not observed with the isolated histone H3 substrate but requires a nucleosome substrate. I-CBP112 does not impact nucleosome acetylation by the isolated p300 HAT domain, and the effects of I-CBP112 on p300/CBP can be neutralized by CBP30, suggesting that I-CBP112 likely allosterically activates p300/CBP through bromodomain interactions. Using mass spectrometry and Western blots, we have found that I-CBP112 particularly stimulates acetylation of Lys18 of histone H3 (H3K18) in nucleosomes, an established in vivo site of p300/CBP. In addition, we show that I-CBP112 enhances H3K18 acetylation in acute leukemia and prostate cancer cells in a concentration range commensurate with its antiproliferative effects. Our findings extend the known pharmacology of bromodomain ligands in the regulation of p300/CBP and suggest a novel approach to modulating histone acetylation in cancer.
[Mh] Termos MeSH primário: Compostos de Bromo/farmacologia
Proteína p300 Associada a E1A/metabolismo
Leucemia/patologia
Nucleossomos/metabolismo
Neoplasias da Próstata/patologia
Fatores de Transcrição de p300-CBP/metabolismo
[Mh] Termos MeSH secundário: Acetilação
Proliferação Celular/efeitos dos fármacos
Cristalografia por Raios X
Histonas/metabolismo
Seres Humanos
Leucemia/tratamento farmacológico
Leucemia/metabolismo
Masculino
Modelos Moleculares
Mutagênese Sítio-Dirigida
Neoplasias da Próstata/tratamento farmacológico
Neoplasias da Próstata/metabolismo
Ligação Proteica
Conformação Proteica
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bromine Compounds); 0 (Histones); 0 (Nucleosomes); EC 2.3.1.48 (E1A-Associated p300 Protein); EC 2.3.1.48 (EP300 protein, human); EC 2.3.1.48 (p300-CBP Transcription Factors)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170527
[Lr] Data última revisão:
170527
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160623
[St] Status:MEDLINE
[do] DOI:10.1021/acs.biochem.6b00480


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[PMID]:26618527
[Au] Autor:Peng H; Chen C; Cantin J; Saunders DM; Sun J; Tang S; Codling G; Hecker M; Wiseman S; Jones PD; Li A; Rockne KJ; Sturchio NC; Giesy JP
[Ad] Endereço:Toxicology Centre, University of Saskatchewan , 44 Campus Drive, Saskatoon, Saskatchewan S7N 5B3, Canada.
[Ti] Título:Untargeted Screening and Distribution of Organo-Bromine Compounds in Sediments of Lake Michigan.
[So] Source:Environ Sci Technol;50(1):321-30, 2016 Jan 05.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previously unreported natural and synthetic organo-bromine compounds (NSOBCs) have been found to contribute more than 99% of total organic bromine (TOB) in environmental matrices. We recently developed a novel untargeted method (data-independent precursor isolation and characteristic fragment, DIPIC-Frag) and identified ∼2000 NSOBCs in two sediments from Lake Michigan. In this study, this method was used to investigate the distributions of these NSOBCs in 23 surficial samples and 24 segments of a sediment core from Lake Michigan. NSOBCs were detected in all 23 surficial samples and exhibited 10- to 100-fold variations in peak abundance among locations. The pattern of distributions of NSOBCs was correlated with depth of the water column (r(2) = 0.61, p < 0.001). Hierarchical cluster analysis showed that sediments in close proximity exhibited similar profiles of NSOBCs. Distributions of NSOBCs in 24 segments of a sediment core dated from 1766 to 2008 were investigated, and samples from similar depths exhibited similar profiles of NSOBCs. NSOBCs were grouped into four clusters (soft-cluster analysis) with different temporal trends of abundances. 515 and 768 of the NSOBCs were grouped into cluster 1 and cluster 3 with increasing temporal trends, especially since 1950, indicating that abundances of these compounds might have been affected by human activities.
[Mh] Termos MeSH primário: Compostos de Bromo/análise
Sedimentos Geológicos/química
Éteres Difenil Halogenados/análise
Hidrocarbonetos Bromados/análise
Lagos/química
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Monitoramento Ambiental/métodos
Michigan
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Bromine Compounds); 0 (Halogenated Diphenyl Ethers); 0 (Hydrocarbons, Brominated); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160105
[Lr] Data última revisão:
160105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151201
[St] Status:MEDLINE
[do] DOI:10.1021/acs.est.5b04709


  3 / 214 MEDLINE  
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[PMID]:25754847
[Au] Autor:Oka Y; Shuker S; Tkachi N
[Ad] Endereço:Nematology Unit, Gilat Research Centre, Agricultural Research Organisation, Negev, Israel.
[Ti] Título:Nematicidal activity of allyl bromide and dibromo(nitro)methane under laboratory conditions.
[So] Source:Pest Manag Sci;72(1):57-66, 2016 Jan.
[Is] ISSN:1526-4998
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Restrictions on soil fumigants are prompting the development of new compounds for controlling nematodes, other soilborne pathogens and weeds. We evaluated the nematicidal activity of five bromine compounds against Meloidogyne javanica in vitro, and tested the two most effective ones against Pratylenchus penetrans and Xiphinema index in vitro and in soil. RESULTS: Only allyl bromide and dibromo(nitro)methane showed nematicidal activity against M. javanica juveniles in vitro at <320 mg L(-1) . Allyl bromide killed M. javanica and P. penetrans at 20 mg L(-1), and X. index at 10 mg L(-1), whereas 320 mg dibromo(nitro)methane L(-1) was required to kill P. penetrans. Allyl bromide also showed higher nematicidal activity than dibromo(nitro)methane against M. javanica and P. penetrans in soil. Allyl bromide at 40 and 20 mg L(-1) soil eliminated root galls and nematode eggs on tomato roots grown in M. javanica-inoculated loess and sandy soils respectively, showing higher nematicidal activity than 1,3-dichloropropene. No P. penetrans were recovered from soil treated with 80 mg allyl bromide L(-1) soil or 320 mg dibromo(nitro)methane L(-1) soil. CONCLUSION: Allyl bromide showed high nematicidal activity against all three nematode species, and nematicidal activity of dibromo(nitro)methane was discovered. These compounds could serve as new fumigation nematicides, pending further experiments.
[Mh] Termos MeSH primário: Antinematódeos
Compostos de Bromo
Nematoides
Doenças das Plantas/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Doenças das Plantas/parasitologia
Tylenchoidea
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antinematodal Agents); 0 (Bromine Compounds)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150311
[St] Status:MEDLINE
[do] DOI:10.1002/ps.4001


  4 / 214 MEDLINE  
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[PMID]:25802927
[Au] Autor:Sivey JD; Bickley MA; Victor DA
[Ad] Endereço:Department of Chemistry and Urban Environmental Biogeochemistry Laboratory, Towson University, Towson, Maryland 21252, United States.
[Ti] Título:Contributions of BrCl, Br2, BrOCl, Br2O, and HOBr to regiospecific bromination rates of anisole and bromoanisoles in aqueous solution.
[So] Source:Environ Sci Technol;49(8):4937-45, 2015 Apr 21.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:When bromide-containing waters are chlorinated, conventional wisdom typically assumes HOBr is the only active brominating agent. Several additional and often-overlooked brominating agents (including BrCl, Br2, BrOCl, Br2O) can form in chlorinated waters, albeit at generally lower concentrations than HOBr. The extent to which these additional brominating agents influence bromination rates of disinfection byproduct precursors is, however, poorly understood. Herein, the influence of BrCl, Br2, BrOCl, Br2O, and HOBr toward rates of sequential bromination of anisole was quantified. Conditions affecting bromine speciation (e.g., pH, concentrations of chloride, bromide, and chlorine) were varied, and regiospecific second-order rate constants were calculated for reactions of each brominating agent with anisole, 2-bromoanisole, and 4-bromoanisole. The regioselectivity of anisole bromination changed with pH, consistent with the participation of more than one brominating agent. Under conditions representative of chlorinated drinking water, contributions to bromination rates decreased as BrCl > BrOCl > HOBr > Br2O (Br2 negligible). The second-order rate constant determined for net bromination of anisole by HOBr is up to 3000-times less than reported in previous studies (which assumed HOBr was the only active brominating agent). Accordingly, models that assume HOBr is the only kinetically relevant brominating agent in solutions of free bromine may be insufficient for reactions involving modestly nucleophilic organic compounds.
[Mh] Termos MeSH primário: Anisóis/química
Bromatos/química
Brometos/química
Cloretos/química
Desinfecção/métodos
[Mh] Termos MeSH secundário: Bromo/química
Compostos de Bromo/química
Cloro/química
Halogenação
Cinética
Óxidos/química
Soluções/química
Água/química
Purificação da Água/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anisoles); 0 (Bromates); 0 (Bromides); 0 (Bromine Compounds); 0 (Chlorides); 0 (Oxides); 0 (Solutions); 0 (bromine monoxide); 059QF0KO0R (Water); 4R7X1O2820 (Chlorine); 7G62XY5724 (bromine chloride); B3W693GAZH (anisole); GHT9BV419J (hypobromous acid); SBV4XY874G (Bromine)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150325
[St] Status:MEDLINE
[do] DOI:10.1021/acs.est.5b00205


  5 / 214 MEDLINE  
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[PMID]:25768043
[Au] Autor:Shallcross DE; Leather KE; Bacak A; Xiao P; Lee EP; Ng M; Mok DK; Dyke JM; Hossaini R; Chipperfield MP; Khan MA; Percival CJ
[Ad] Endereço:†School of Chemistry, University of Bristol, Bristol BS8 1TS, U.K.
[Ti] Título:Reaction between CH3O2 and BrO radicals: a new source of upper troposphere lower stratosphere hydroxyl radicals.
[So] Source:J Phys Chem A;119(19):4618-32, 2015 May 14.
[Is] ISSN:1520-5215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Over the last two decades it has emerged that measured hydroxyl radical levels in the upper troposphere are often underestimated by models, leading to the assertion that there are missing sources. Here we report laboratory studies of the kinetics and products of the reaction between CH3O2 and BrO radicals that shows that this could be an important new source of hydroxyl radicals:BrO + CH3O2 → products (1). The temperature dependent value in Arrhenius form of k(T) is k1 = (2.42­0.72+1.02) × 10­14 exp[(1617 ± 94)/T] cm3 molecule­1 s­1. In addition, CH2OO and HOBr are believed to be the major products. Global model results suggest that the decomposition of H2COO to form OH could lead to an enhancement in OH of up to 20% in mid-latitudes in the upper troposphere and in the lower stratosphere enhancements in OH of 2­9% are inferred from model integrations. In addition, reaction 1 aids conversion of BrO to HOBr and slows polar ozone loss in the lower stratosphere.
[Mh] Termos MeSH primário: Atmosfera/química
Compostos de Bromo/química
Radical Hidroxila/química
Metano/química
Peróxidos/química
[Mh] Termos MeSH secundário: Simulação por Computador
Cinética
Análise dos Mínimos Quadrados
Modelos Lineares
Metano/análogos & derivados
Modelos Químicos
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bromine Compounds); 0 (Peroxides); 3352-57-6 (Hydroxyl Radical); OP0UW79H66 (Methane)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150514
[Lr] Data última revisão:
150514
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150314
[St] Status:MEDLINE
[do] DOI:10.1021/jp5108203


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[PMID]:25591991
[Au] Autor:Rosokha SV; Traversa A
[Ad] Endereço:Department of Biological, Chemical and Physical Sciences, Roosevelt University, Chicago, IL 60605, USA. srosokha@roosevelt.edu.
[Ti] Título:From charge transfer to electron transfer in halogen-bonded complexes of electrophilic bromocarbons with halide anions.
[So] Source:Phys Chem Chem Phys;17(7):4989-99, 2015 Feb 21.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Experimental and computational studies of the halogen-bonded complexes, [R-Br, X(-)], of bromosubstituted electrophiles, R-Br, and halide anions, X(-), revealed that decrease of a gap between the frontier orbitals of interacting species led to reduction of the energy of the optical charge-transfer transition and to increase in the ground-state charge transfer (X(-) → R-Br) in their associates. These variations were accompanied by weakening of the intramolecular, C-Br, and strengthening of the intermolecular, BrX(-), bonds. In the limit of the strongest electron donor-acceptor pairs, formation of the halogen-bonded complexes was followed by the oxidation of iodide to triiodide, which took place despite the fact that the I(-) → R-Br electron-transfer step was highly endergonic and the calculated outer-sphere rate constant was negligibly small. However, the calculated barrier for the inner-sphere electron transfer accompanied by the halogen transfer, R-BrI(-) → R˙Br-I(-)˙, was nearly 24 kcal mol(-1) lower as compared to that calculated for the outer-sphere process and the rate constant of such reaction was consistent with the experimental kinetics. A dramatic decrease of the electron-transfer barriers (leading to 18-orders of magnitude increase of the rate constant) was related to the strong electronic coupling of the donor and acceptor within the halogen-bonded precursor complex, as well as to the lower solvent reorganization energy and the successor-complex stabilization.
[Mh] Termos MeSH primário: Compostos de Bromo/química
Compostos Inorgânicos de Carbono/química
Halogênios/química
[Mh] Termos MeSH secundário: Ânions/química
Transporte de Elétrons
Elétrons
Modelos Moleculares
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anions); 0 (Bromine Compounds); 0 (Carbon Compounds, Inorganic); 0 (Halogens)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150205
[Lr] Data última revisão:
150205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150117
[St] Status:MEDLINE
[do] DOI:10.1039/c4cp05220j


  7 / 214 MEDLINE  
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[PMID]:25464295
[Au] Autor:Garcia-Segura S; Keller J; Brillas E; Radjenovic J
[Ad] Endereço:Advanced Water Management Centre, The University of Queensland, Level 4, Gehrmann Bld. (60), St Lucia, QLD 072, Australia; Laboratori d'Electroquímica dels Materials i del Medi Ambient, Departament de Química Física, Facultat de Química, Universitat de Barcelona, Martí i Franquès 1-11, 08028 Barcelo
[Ti] Título:Removal of organic contaminants from secondary effluent by anodic oxidation with a boron-doped diamond anode as tertiary treatment.
[So] Source:J Hazard Mater;283:551-7, 2015.
[Is] ISSN:1873-3336
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Electrochemical advanced oxidation processes (EAOPs) have been widely investigated as promising technologies to remove trace organic contaminants from water, but have rarely been used for the treatment of real waste streams. Anodic oxidation with a boron-doped diamond (BDD) anode was applied for the treatment of secondary effluent from a municipal sewage treatment plant containing 29 target pharmaceuticals and pesticides. The effectiveness of the treatment was assessed from the contaminants decay, dissolved organic carbon and chemical oxygen demand removal. The effect of applied current and pH was evaluated. Almost complete mineralization of effluent organic matter and trace contaminants can be obtained by this EAOP primarily due to the action of hydroxyl radicals formed at the BDD surface. The oxidation of Cl(-) ions present in the wastewater at the BDD anode gave rise to active chlorine species (Cl2/HClO/ClO(-)), which are competitive oxidizing agents yielding chloramines and organohalogen byproducts, quantified as adsorbable organic halogen. However, further anodic oxidation of HClO/ClO(-) species led to the production of ClO3(-) and ClO4(-) ions. The formation of these species hampers the application as a single-stage tertiary treatment, but posterior cathodic reduction of chlorate and perchlorate species may reduce the risks associated to their presence in the environment.
[Mh] Termos MeSH primário: Boro
Diamante
Eletroquímica/métodos
Praguicidas/química
Preparações Farmacêuticas/química
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Análise da Demanda Biológica de Oxigênio
Compostos de Bromo/análise
Eletrodos
Hidrocarbonetos Clorados/análise
Radical Hidroxila/análise
Oxirredução
Esgotos/química
Águas Residuais/química
Poluentes Químicos da Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bromine Compounds); 0 (Hydrocarbons, Chlorinated); 0 (Pesticides); 0 (Pharmaceutical Preparations); 0 (Sewage); 0 (Waste Water); 0 (Water Pollutants, Chemical); 3352-57-6 (Hydroxyl Radical); 7782-40-3 (Diamond); N9E3X5056Q (Boron)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:141216
[Lr] Data última revisão:
141216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141203
[St] Status:MEDLINE


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[PMID]:25452238
[Au] Autor:Miyamoto K
[Ad] Endereço:Graduate School of Pharmaceutical Sciences, The University of Tokyo.
[Ti] Título:[Synthesis of hypervalent organo-λ(3)-bromanes and their reactions by using leaving group ability of λ(3)-bromanyl group].
[So] Source:Yakugaku Zasshi;134(12):1287-300, 2014.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Hypervalent organo-λ(3)-iodanes have attracted great interest in organic synthesis; however, the chemistry of hypervalent organo-λ(3)-bromanes remains largely unexplored, mainly because of synthetic difficulties. Iodobenzene is readily oxidized by common oxidants such as peracids under mild conditions, whereas bromobenzene is inert. Since the ionization potential of bromobenzene (8.98 eV) is higher than that of iodobenzene (8.69 eV), hypervalent-λ(3)-bromane would show much higher reactivity. We overcame this problem by using difluoro(aryl)-λ(3)-bromane (Frohn's reagent), which serves as a pivotal progenitor of various λ(3)-bromanes including imino-λ(3)-bromane, cyclopent-1-enyl-λ(3)-bromane, (E)-ß-alkylvinyl-λ(3)-bromane, and diacetoxy-λ(3)-bromane. These reagents possess highly unusual reactivity based on the enormously enhanced nucleofugality of the aryl-λ(3)-bromanyl group.
[Mh] Termos MeSH primário: Compostos de Bromo/síntese química
[Mh] Termos MeSH secundário: Cátions/química
Temperatura Alta
Cinética
Oxirredução
Solventes/química
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Bromine Compounds); 0 (Cations); 0 (Solvents)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:141202
[Lr] Data última revisão:
141202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141203
[St] Status:MEDLINE


  9 / 214 MEDLINE  
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[PMID]:24967541
[Au] Autor:Ben Ahmed A; Feki H; Abid Y
[Ad] Endereço:Laboratory of Applied Physics, University of Sciences of Sfax, 3018, BP 802 Tunisia. Electronic address: ahmedlpa@yahoo.fr.
[Ti] Título:Synthesis, crystal structure, vibrational spectroscopy, optical properties and theoretical studies of a new organic-inorganic hybrid material: [((CH3)2NH2)(+)]6·[(BiBr6)(3-)]2.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;133:357-64, 2014 Dec 10.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new organic-inorganic hybrid material, [((CH3)2NH2)(+)]6·[(BiBr6)(3-)]2, has been synthesized and characterized by X-ray diffraction, FT-IR, Raman spectroscopy and UV-Visible absorption. The studied compound crystallizes in the triclinic system, space group P1¯ with the following parameters: a=8.4749(6)(Å), b=17.1392(12)(Å), c=17.1392(12)(Å), α=117.339(0)°, ß=99.487(0)°, γ=99.487(0)° and Z=2. The crystal lattice is composed of a two discrete (BiBr6)(3-) anions surrounded by six ((CH3)2NH2)(+) cations. Complex hydrogen bonding interactions between (BiBr6)(3-) and organic cations from a three-dimensional network. Theoretical calculations were performed using density functional theory (DFT) for studying the molecular structure, vibrational spectra and optical properties of the investigated molecule in the ground state. The full geometry optimization of designed system is performed using DFT method at B3LYP/LanL2DZ level of theory using the Gaussian03. The optimized geometrical parameters obtained by DFT calculations are in good agreement with single crystal XRD data. The vibrational spectral data obtained from FT-IR and Raman spectra are assigned based on the results of the theoretical calculations. The energy and oscillator strength calculated by Time-Dependent Density Functional Theory (TD-DFT) results complements with the experimental findings. The simulated spectra satisfactorily coincide with the experimental UV-Visible spectrum. The results show good consistent with the experiment and confirm the contribution of metal orbital to the HOMO-LUMO boundary.
[Mh] Termos MeSH primário: Bismuto/química
Compostos de Bromo/química
Compostos Organometálicos/química
[Mh] Termos MeSH secundário: Compostos de Bromo/síntese química
Cristalografia por Raios X
Ligações de Hidrogênio
Modelos Moleculares
Compostos Organometálicos/síntese química
Teoria Quântica
Espectroscopia de Infravermelho com Transformada de Fourier
Análise Espectral Raman
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bromine Compounds); 0 (Organometallic Compounds); U015TT5I8H (Bismuth)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:140723
[Lr] Data última revisão:
140723
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140627
[St] Status:MEDLINE


  10 / 214 MEDLINE  
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[PMID]:24905215
[Au] Autor:Gottardi W; Klotz S; Nagl M
[Ad] Endereço:Division of Hygiene and Medical Microbiology, Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria.
[Ti] Título:Superior bactericidal activity of N-bromine compounds compared to their N-chlorine analogues can be reversed under protein load.
[So] Source:J Appl Microbiol;116(6):1427-37, 2014 Jun.
[Is] ISSN:1365-2672
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: To investigate and compare the bactericidal activity (BA) of active bromine and chlorine compounds in the absence and presence of protein load. METHODS AND RESULTS: Quantitative killing tests against Escherichia coli and Staphylococcus aureus were performed both in the absence and in the presence of peptone with pairs of isosteric active chlorine and bromine compounds: hypochlorous and hypobromous acid (HOCl and HOBr), dichloro- and dibromoisocyanuric acid, chlorantine and bromantine (1,3-dibromo- and 1,3 dichloro-5,5-dimethylhydantoine), chloramine T and bromamine T (N-chloro- and N-bromo-4-methylbenzenesulphonamide sodium), and N-chloro- and N-bromotaurine sodium. To classify the bactericidal activities on a quantitative basis, an empirical coefficient named specific bactericidal activity (SBA), founded on the parameters of killing curves, was defined: SBA= mean log reductions/(mean exposure times x concentration) [mmol 1(-1) min (-1)]. In the absence of peptone, tests with washed micro-organisms revealed a throughout higher BA of bromine compounds with only slight differences between single substances. This was in contrast to chlorine compounds, whose killing times differed by a factor of more than four decimal powers. As a consequence, also the isosteric pairs showed according differences. In the presence of peptone, however, bromine compounds showed an increased loss of BA, which partly caused a reversal of efficacy within isosteric pairs. CONCLUSIONS: In medical practice, weakly oxidizing active chlorine compounds like chloramines have the highest potential as topical anti-infectives in the presence of proteinaceous material (mucous membranes, open wounds). Active bromine compounds, on the other hand, have their chance at insensitive body regions with low organic matter, for example skin surfaces. SIGNIFICANCE AND IMPACT OF THE STUDY: The expected protein load is one of the most important parameters for selection of a suited active halogen compound.
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/farmacologia
Compostos de Bromo/farmacologia
Compostos Clorados/farmacologia
Peptonas/química
[Mh] Termos MeSH secundário: Bromatos/farmacologia
Cloraminas/farmacologia
Escherichia coli/efeitos dos fármacos
Ácido Hipocloroso/farmacologia
Staphylococcus aureus/efeitos dos fármacos
Taurina/análogos & derivados
Taurina/farmacologia
Compostos de Tosil/farmacologia
Triazinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); 0 (Bromates); 0 (Bromine Compounds); 0 (Chloramines); 0 (Chlorine Compounds); 0 (Peptones); 0 (Tosyl Compounds); 0 (Triazines); 15114-43-9 (dibromoisocyanuric acid); 1EQV5MLY3D (Taurine); 4IU6VSV0EI (chloramine-T); 52316-57-1 (N-bromotaurine); 712K4CDC10 (Hypochlorous Acid); GHT9BV419J (hypobromous acid)
[Em] Mês de entrada:1411
[Cu] Atualização por classe:140609
[Lr] Data última revisão:
140609
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140607
[St] Status:MEDLINE
[do] DOI:10.1111/jam.12474



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