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  1 / 20180 MEDLINE  
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[PMID]:28459069
[Au] Autor:Esposito P; La Porta E; Calatroni M; Grignano MA; Milanesi S; Verzola D; Battaglia Y; Gregorini M; Libetta C; Garibotto G; Rampino T
[Ad] Endereço:Department of Nephrology, Dialysis and Transplantation, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
[Ti] Título:Modulation of Myostatin/Hepatocyte Growth Factor Balance by Different Hemodialysis Modalities.
[So] Source:Biomed Res Int;2017:7635459, 2017.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study we investigated the relevance of myostatin and Hepatocyte Growth Factor (HGF) in patients undergoing hemodialysis HD and the influence of different HD modalities on their levels. We performed a prospective crossover study in which HD patients were randomized to undergo 3-month treatment periods with bicarbonate hemodialysis (BHD) followed by online hemodiafiltration (HDF). Clinical data, laboratory parameters, and myostatin and HGF serum levels were collected and compared. Ten patients and six controls (C) were evaluated. In any experimental condition myostatin and HGF levels were higher in HD than in C. At enrollment and after BHD there were not significant correlations, whereas at the end of the HDF treatment period myostatin and HGF were inversely correlated ( -0.65, < 0.05), myostatin serum levels inversely correlated with transferrin ( -0.73, < 0.05), and HGF levels that resulted positively correlated with BMI ( 0.67, < 0.05). Moving from BHD to HDF, clinical and laboratory parameters were unchanged, as well as serum HGF, whereas myostatin levels significantly decreased (6.3 ± 4.1 versus 4.3 ± 3.1 ng/ml, < 0.05). Modulation of myostatin levels and myostatin/HGF balance by the use of different HD modalities might represent a novel approach to the prevention and treatment of HD-related muscle wasting syndrome.
[Mh] Termos MeSH primário: Hemodiafiltração/métodos
Hemodiafiltração/estatística & dados numéricos
Fator de Crescimento de Hepatócito/metabolismo
Miostatina/metabolismo
[Mh] Termos MeSH secundário: Idoso
Bicarbonatos
Estudos Cross-Over
Feminino
Fator de Crescimento de Hepatócito/sangue
Seres Humanos
Masculino
Meia-Idade
Miostatina/sangue
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bicarbonates); 0 (HGF protein, human); 0 (MSTN protein, human); 0 (Myostatin); 67256-21-7 (Hepatocyte Growth Factor)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1155/2017/7635459


  2 / 20180 MEDLINE  
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[PMID]:29173354
[Au] Autor:Feldman M; Dickson B
[Ad] Endereço:Department of Internal Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas. Electronic address: MarkFeldman@TexasHealth.org.
[Ti] Título:Plasma Electrolyte Distributions in Humans-Normal or Skewed?
[So] Source:Am J Med Sci;354(5):453-457, 2017 11.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: It is widely believed that plasma electrolyte levels are normally distributed. Statistical tests and calculations using plasma electrolyte data are often reported based on this assumption of normality. Examples include t tests, analysis of variance, correlations and confidence intervals. The purpose of our study was to determine whether plasma sodium (Na ), potassium (K ), chloride (Cl ) and bicarbonate [Formula: see text] distributions are indeed normally distributed. METHODS: We analyzed plasma electrolyte data from 237 consecutive adults (137 women and 100 men) who had normal results on a standard basic metabolic panel which included plasma electrolyte measurements. The skewness of each distribution (as a measure of its asymmetry) was compared to the zero skewness of a normal (Gaussian) distribution. RESULTS: The plasma Na distribution was skewed slightly to the right, but the skew was not significantly different from zero skew. The plasma Cl distribution was skewed slightly to the left, but again the skew was not significantly different from zero skew. On the contrary, both the plasma K and [Formula: see text] distributions were significantly skewed to the right (P < 0.01 zero skew). There was also a suggestion from examining frequency distribution curves that K and [Formula: see text] distributions were bimodal. CONCLUSIONS: In adults with a normal basic metabolic panel, plasma potassium and bicarbonate levels are not normally distributed and may be bimodal. Thus, statistical methods to evaluate these 2 plasma electrolytes should be nonparametric tests and not parametric ones that require a normal distribution.
[Mh] Termos MeSH primário: Eletrólitos/sangue
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Bicarbonatos/sangue
Cloretos/sangue
Feminino
Seres Humanos
Masculino
Meia-Idade
Potássio/sangue
Sódio/sangue
Distribuições Estatísticas
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bicarbonates); 0 (Chlorides); 0 (Electrolytes); 9NEZ333N27 (Sodium); RWP5GA015D (Potassium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  3 / 20180 MEDLINE  
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[PMID]:29314793
[Au] Autor:Bancevic V; Aleksic P; Stamenkovic D; Pejcic T; Milovic N; Kovacevic B; Cerovic S
[Ti] Título:Neobladder "Belgrade pouch": Metabolic consideration.
[So] Source:Vojnosanit Pregl;73(7):626-30, 2016 Jul.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: The ileal neobladder should be a lowpressure reservoir with acceptable volume and relatively small resorptive surface. A larger inner surface of the ileal pouch is associated with the high resorption of urine metabolites through intestinal mucosa and systemic metabolic disturbances, while a too small pouch results in a higher frequency of voiding and incontinency. The aim of this study was to investigate it is possible to create a neobladder from a shorter ileal segment compared to standard surgical techniques, and reduce metabolic complications. Methods: This prospective study included 77 male patients, scheduled for radical cystectomy and orthotopic neobladder derivation. The patients were divided into two groups: the standard pouch (SP) group of 37 patients scheduled for standard orthotopic neobladder, using a 50−70 cm long terminal ileum segment; the "Belgrade pouch" (BP) group of 40 patients scheduled for original, orthotopic urinary reservoir, using a 25−35 cm long terminal ileum segment. We measured neobladder capacity, acidosis, base excess and bicarbonate concentration in the postoperative month 3rd, 6th, 12th and 15th. Results: At the end of the study, the patients from the SP group had much higher neobladder capacity than the natural bladder − 750 mL (range 514−2,050 mL); in contrast, the patients from the BP group had average capacity of 438 mL (range 205−653 mL) (p < 0.001). At the end of the study, there were more patients with acidosis (37.8% : 2.5%), base excess (35.1% : 7.5%) and low bicarbonate level (40.5% : 20.0%) in the SP group, than in the BP group, respectively (p < 0.001). Conclusion: "Belgrade pouch", make from 25−35 cm long terminal ileum segment may obtain adequate capacity and lower rate of metabolic disturbances than standard, high capacity orthotopic neobladders.
[Mh] Termos MeSH primário: Carcinoma de Células de Transição/cirurgia
Cistectomia/métodos
Neoplasias da Bexiga Urinária/cirurgia
Coletores de Urina/fisiologia
[Mh] Termos MeSH secundário: Acidose/prevenção & controle
Adulto
Bicarbonatos/metabolismo
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bicarbonates)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150113064B


  4 / 20180 MEDLINE  
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[PMID]:29121567
[Au] Autor:Li Y; Li L; Chen ZX; Zhang J; Gong L; Wang YX; Zhao HQ; Mu Y
[Ad] Endereço:CAS Key Laboratory of Urban Pollutant Conversion, Collaborative Innovation Centre of Suzhou Nano Science and Technology, Department of Chemistry, University of Science and Technology of China, Hefei, China.
[Ti] Título:Carbonate-activated hydrogen peroxide oxidation process for azo dye decolorization: Process, kinetics, and mechanisms.
[So] Source:Chemosphere;192:372-378, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Advanced oxidation processes offer effective solutions in treating wastewater from various industries. This study is the first time to investigate the potential of carbonate-activated hydrogen peroxide (CAP) oxidation process for the removal of organic pollutant from highly alkaline wastewaters. Azo dye acid orange 7 (AO7) was selected as a model pollutant. The influences of various parameters on AO7 decolorization by the CAP oxidation were evaluated. Furthermore, the active species involved in AO7 degradation were explored using scavenger experiments and electron spin resonance analysis. Additionally, AO7 degradation products by the CAP oxidation were identified to elucidate possible transformation pathways. Results showed that the CAP oxidation had better AO7 decolorization performance compared to bicarbonate-activated hydrogen peroxide method. The AO7 decolorization efficiency augmented from 3.70 ± 0.76% to 54.27 ± 2.65% when carbonate concentration was increased from 0 to 50 mM at pH 13.0, and then changed slightly with further increasing carbonate concentration to 70 mM. It increased almost linearly from 5.95 ± 0.32% to 94.03 ± 0.39% as H O concentration was increased from 5 to 50 mM. Moreover, trace amount of Co(II) could facilitate AO7 decolorization by the CAP reaction. Superoxide and carbonate radicals might be the main reactive oxygen species involved in the CAP process. Finally, a possible degradation pathway of AO7 by the CAP oxidation was proposed based on the identified products.
[Mh] Termos MeSH primário: Compostos Azo/química
Carbonatos/química
Corantes/química
Recuperação e Remediação Ambiental/métodos
Peróxidos/química
[Mh] Termos MeSH secundário: Benzenossulfonatos
Bicarbonatos
Poluentes Ambientais/química
Peróxido de Hidrogênio
Cinética
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Azo Compounds); 0 (Benzenesulfonates); 0 (Bicarbonates); 0 (Carbonates); 0 (Coloring Agents); 0 (Environmental Pollutants); 0 (Peroxides); BBX060AN9V (Hydrogen Peroxide); Q1LIY3BO0U (2-naphthol orange)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171110
[St] Status:MEDLINE


  5 / 20180 MEDLINE  
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[PMID]:29381982
[Au] Autor:Capusa C; Stefan G; Stancu S; Lipan M; Tsur LD; Mircescu G
[Ad] Endereço:Nephrology Department, "Carol Davila" University of Medicine and Pharmacy.
[Ti] Título:Metabolic acidosis of chronic kidney disease and subclinical cardiovascular disease markers: Friend or foe?
[So] Source:Medicine (Baltimore);96(47):e8802, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The effect of chronic metabolic acidosis (MA) on cardiovascular disease (CVD) in the setting of chronic kidney disease (CKD) is largely unknown. Therefore, we aimed to study this relationship in nondialysis CKD patients.This cross-sectional, single-center study prospectively enrolled 95 clinically stable CKD patients (median age 61 (58, 65) years, 60% male, median eGFR 27 (22, 32) mL/min). Data on CKD etiology, CVD history, CVD traditional, and nontraditional risk factors were obtained. Also, markers of subclinical CVD were assessed: intima-media thickness (IMT), abdominal aortic calcifications (Kauppila score-AACs), cardio-ankle vascular index (CAVI), ankle-brachial index (ABI), ejection fraction, and interventricular septum thickness. Using the serum bicarbonate cutoff value of 22 mEq/L, comparisons between MA (<22 mEq/L; 43 patients) and non-MA (≥22 mEq/L; 52 patients) groups were performed.Vascular (40%), tubulointerstitial (24%), and glomerular (22%) nephropathies were the main causes of CKD. Twenty-three percent of patients had diabetes mellitus, but only 5% were considered to have diabetic nephropathy. Patients with chronic MA had lower eGFR (P < .01), higher iPTH (P = .01), higher serum phosphate (P < .01), and increased serum cholesterol (P = .04) and triglycerides (P = .01).Higher ABI (P = .04), lower IMT (P = .03), CAVI (P = .05), and AACs (P = .03) were found in patients with chronic MA.Separate binomial logistic regression models were performed using ABI (cutoff 0.9), CAVI (cutoff 9), IMT (cutoff 0.1 cm), and AACs (cutoff 1) as dependent variables. MA was used as independent variable and adjustments were made for iPTH, serum phosphate, eGFR, proteinuria, cholesterol, triglycerides, CVD score. The absence of MA was retained as an independent predictor only for the presence of AACs.In conclusion, the present study shows a potential advantageous effect of MA on vascular calcifications in predialysis CKD patients. Thus, a guideline relaxation of the serum bicarbonate target might prove to be beneficial in CKD patients at high risk of vascular calcifications. However, one should always consider the negative effects of MA. Therefore, additional research is warranted before any clear clinical recommendation.
[Mh] Termos MeSH primário: Acidose/sangue
Bicarbonatos/sangue
Doenças Cardiovasculares/etiologia
Insuficiência Renal Crônica/sangue
Calcificação Vascular/etiologia
[Mh] Termos MeSH secundário: Acidose/etiologia
Acidose/fisiopatologia
Idoso
Índice Tornozelo-Braço
Biomarcadores/sangue
Espessura Intima-Media Carotídea
Colesterol/sangue
Estudos Transversais
Feminino
Taxa de Filtração Glomerular
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Fosfatos/sangue
Estudos Prospectivos
Insuficiência Renal Crônica/complicações
Insuficiência Renal Crônica/fisiopatologia
Fatores de Risco
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bicarbonates); 0 (Biomarkers); 0 (Phosphates); 0 (Triglycerides); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008802


  6 / 20180 MEDLINE  
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[PMID]:29281691
[Au] Autor:Sellers ZM; Illek B; Figueira MF; Hari G; Joo NS; Sibley E; Souza-Menezes J; Morales MM; Fischer H; Wine JJ
[Ad] Endereço:Division of Pediatric Gastroenterology, Hepatolfifogy, and Nutrition, Stanford University, Palo Alto, CA, United States of America.
[Ti] Título:Impaired PGE2-stimulated Cl- and HCO3- secretion contributes to cystic fibrosis airway disease.
[So] Source:PLoS One;12(12):e0189894, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Airway mucociliary clearance (MCC) is an important defense mechanism against pulmonary infections and is compromised in cystic fibrosis (CF). Cl- and HCO3- epithelial transport are integral to MCC. During pulmonary infections prostaglandin E2 (PGE2) production is abundant. AIM: To determine the effect of PGE2 on airway Cl- and HCO3- secretion and MCC in normal and CF airways. METHODS: We examined PGE2 stimulated MCC, Cl- and HCO3- secretion using ferret trachea, human bronchial epithelial cell cultures (CFBE41o- with wildtype CFTR (CFBE41 WT) or homozygous F508del CFTR (CFBE41 CF) and human normal bronchial submucosal gland cell line (Calu-3) in Ussing chambers with or without pH-stat. RESULTS: PGE2 stimulated MCC in a dose-dependent manner and was partially impaired by CFTRinh-172. PGE2-stimulated Cl- current in ferret trachea was partially inhibited by CFTRinh-172, with niflumic acid eliminating the residual current. CFBE41 WT cell monolayers produced a robust Cl- and HCO3- secretory response to PGE2, both of which were completely inhibited by CFTRinh-172. CFBE41 CF cells exhibited no response to PGE2. In Calu-3 cells, PGE2 stimulated Cl- and HCO3- secretion. Cl- secretion was partially inhibited by CFTRinh-172, with additional inhibition by niflumic acid. HCO3- secretion was completely inhibited by CFTRinh-172. CONCLUSIONS: PGE2 stimulates bronchotracheal MCC and this response is decreased in CF. In CF airway, PGE2-stimulated Cl- and HCO3- conductance is impaired and may contribute to decreased MCC. There remains a CFTR-independent Cl- current in submucosal glands, which if exploited, could represent a means of improving airway Cl- secretion and MCC in CF.
[Mh] Termos MeSH primário: Bicarbonatos/metabolismo
Brônquios/efeitos dos fármacos
Cloretos/metabolismo
Fibrose Cística/metabolismo
Dinoprostona/farmacologia
Traqueia/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Brônquios/patologia
Brônquios/secreção
Células Cultivadas
Seres Humanos
Técnicas In Vitro
Traqueia/secreção
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bicarbonates); 0 (Chlorides); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189894


  7 / 20180 MEDLINE  
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[PMID]:29100119
[Au] Autor:Dixit F; Barbeau B; Mohseni M
[Ad] Endereço:Department of Chemical and Biological Engineering, University of British Columbia, Vancouver, Canada.
[Ti] Título:Simultaneous uptake of NOM and Microcystin-LR by anion exchange resins: Effect of inorganic ions and resin regeneration.
[So] Source:Chemosphere;192:113-121, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study investigated the efficiency of a strongly basic macroporous anion exchange resin for the co-removal of Microcystin-LR (MCLR) and natural organic matter (NOM) in waters affected by toxic algal blooms. Environmental factors influencing the uptake behavior included MCLR and resin concentrations, NOM and anionic species, specifically nitrate, sulphate and bicarbonate. A860 resin exhibited an excellent adsorption capacity of 3800 µg/g; more than 60% of the MCLR removal was achieved within 10 min with a resin dosage of 200 mg/L (∼1 mL/L). Further, kinetic studies revealed that the overall removal of MCLR is influenced by both external diffusion and intra-particle diffusion. Increasing NOM concentration resulted in a significant reduction of MCLR uptake, especially at lower resin dosages, where a competitive uptake between the charged NOM fractions and MCLR was observed due to limited active sites. In addition, MCLR uptake was significantly reduced in the presence of sulphate and nitrate in the water matrix. Moreover, performance of the resin proved to be stable from one regeneration cycle to another. Approximately 80% of MCLR and 50% of dissolved organic carbon (DOC) were recovered in the regenerated brine. Evidences of resin saturation and site reduction were also observed after 2000 bed volumes (BV) of operation. For all the investigated water matrices, a resin dosage of 1000 mg/L (∼4.5 mL/L) was sufficient to lower MCLR concentration from 100 µg/L to below the World Health Organization guideline of 1 µg/L, while simultaneously providing more than 80% NOM removal.
[Mh] Termos MeSH primário: Resinas de Troca de Ânions/química
Poluentes Químicos da Água/química
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Adsorção
Bicarbonatos/química
Cinética
Microcistinas/isolamento & purificação
Nitratos/química
Sulfatos/química
Purificação da Água/instrumentação
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anion Exchange Resins); 0 (Bicarbonates); 0 (Microcystins); 0 (Nitrates); 0 (Sulfates); 0 (Water Pollutants, Chemical); EQ8332842Y (cyanoginosin LR)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171104
[St] Status:MEDLINE


  8 / 20180 MEDLINE  
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[PMID]:29253861
[Au] Autor:Eich G; Bartosova M; Tischer C; Wlodkowski TT; Schaefer B; Pichl S; Kraewer N; Ranchin B; Vondrak K; Liebau MC; Hackert T; Schmitt CP
[Ad] Endereço:Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany.
[Ti] Título:Bicarbonate buffered peritoneal dialysis fluid upregulates angiopoietin-1 and promotes vessel maturation.
[So] Source:PLoS One;12(12):e0189903, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ultrafiltration decline is a progressive issue for patients on chronic peritoneal dialysis (PD) and can be caused by peritoneal angiogenesis induced by PD fluids. A recent pediatric trial suggests better preservation of ultrafiltration with bicarbonate versus lactate buffered fluid; underlying molecular mechanisms are unknown. METHODS: Angiogenic cytokine profile, tube formation capacity and Receptor Tyrosine Kinase translocation were assessed in primary human umbilical vein endothelial cells following incubation with bicarbonate (BPDF) and lactate buffered (LPDF), pH neutral PD fluid with low glucose degradation product content and lactate buffered, acidic PD fluid with high glucose degradation product content (CPDF). Peritoneal biopsies from age-, PD-vintage- and dialytic glucose exposure matched, peritonitis-free children on chronic PD underwent automated histomorphometry and immunohistochemistry. RESULTS: In endothelial cells angiopoietin-1 mRNA and protein abundance increased 200% upon incubation with BPDF, but decreased by 70% with LPDF as compared to medium control; angiopoietin-2 remained unchanged. Angiopoietin-1/Angiopoietin-2 protein ratio was 15 and 3-fold increased with BPDF compared to LPDF and medium. Time-lapse microscopy with automated network analysis demonstrated less endothelial cell tube formation with BPDF compared to LPDF and CPDF incubation. Receptor Tyrosine Kinase translocated to the cell membrane in BPDF but not in LPDF or CPDF incubated endothelial cells. In children dialyzed with BPDF peritoneal vessels were larger and angiopoietin-1 abundance in CD31 positive endothelium higher compared to children treated with LPDF. CONCLUSION: Bicarbonate buffered PD fluid promotes vessel maturation via upregulation of angiopoietin-1 in vitro and in children on dialysis. Our findings suggest a molecular mechanism for the observed superior preservation of ultrafiltration capacity with bicarbonate buffered PD fluid with low glucose degradation product content.
[Mh] Termos MeSH primário: Angiopoietina-1/metabolismo
Bicarbonatos/química
Tampões (Química)
Diálise Peritoneal
[Mh] Termos MeSH secundário: Adolescente
Angiopoietina-2/metabolismo
Biópsia
Criança
Doença Crônica
Citocinas/metabolismo
Células Endoteliais/metabolismo
Glucose/química
Células Endoteliais da Veia Umbilical Humana
Seres Humanos
Concentração de Íons de Hidrogênio
Nefropatias/terapia
Lactatos/química
Peritônio/patologia
Molécula-1 de Adesão Celular Endotelial de Plaquetas/metabolismo
Receptores Proteína Tirosina Quinases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ANGPT1 protein, human); 0 (ANGPT2 protein, human); 0 (Angiopoietin-1); 0 (Angiopoietin-2); 0 (Bicarbonates); 0 (Buffers); 0 (Cytokines); 0 (Lactates); 0 (Platelet Endothelial Cell Adhesion Molecule-1); EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189903


  9 / 20180 MEDLINE  
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[PMID]:27779334
[Au] Autor:Le Page LM; Ball DR; Ball V; Dodd MS; Miller JJ; Heather LC; Tyler DJ
[Ad] Endereço:Cardiac Metabolism Research Group, Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK.
[Ti] Título:Simultaneous in vivo assessment of cardiac and hepatic metabolism in the diabetic rat using hyperpolarized MRS.
[So] Source:NMR Biomed;29(12):1759-1767, 2016 Dec.
[Is] ISSN:1099-1492
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Understanding and assessing diabetic metabolism is vital for monitoring disease progression and improving treatment of patients. In vivo assessments, using MRI and MRS, provide non-invasive and accurate measurements, and the development of hyperpolarized C spectroscopy in particular has been demonstrated to provide valuable metabolic data in real time. Until now, studies have focussed on individual organs. However, diabetes is a systemic disease affecting multiple tissues in the body. Therefore, we have developed a technique to simultaneously measure metabolism in both the heart and liver during a single acquisition. A hyperpolarized C MRS protocol was developed to allow acquisition of metabolic data from the heart and liver during a single scan. This protocol was subsequently used to assess metabolism in the heart and liver of seven control male Wistar rats and seven diabetic rats (diabetes was induced by three weeks of high-fat feeding and a 30 mg/kg injection of streptozotocin). Using our new acquisition, we observed decreased cardiac and hepatic pyruvate dehydrogenase flux in our diabetic rat model. These diabetic rats also had increased blood glucose levels, decreased insulin, and increased hepatic triglycerides. Decreased production of hepatic [1- C]alanine was observed in the diabetic group, but this change was not present in the hearts of the same diabetic animals. We have demonstrated the ability to measure cardiac and hepatic metabolism simultaneously, with sufficient sensitivity to detect metabolic alterations in both organs. Further, we have non-invasively observed the different reactions of the heart and liver to the metabolic challenge of diabetes.
[Mh] Termos MeSH primário: Espectroscopia de Ressonância Magnética Nuclear de Carbono-13
Diabetes Mellitus/metabolismo
Fígado/metabolismo
Análise do Fluxo Metabólico
Imagem Molecular/métodos
Miocárdio/metabolismo
Ácido Pirúvico/metabolismo
[Mh] Termos MeSH secundário: Alanina/metabolismo
Algoritmos
Animais
Bicarbonatos/metabolismo
Sistemas de Computação
Ácido Láctico/metabolismo
Aprendizado de Máquina
Masculino
Ratos
Ratos Wistar
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Processamento de Sinais Assistido por Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bicarbonates); 33X04XA5AT (Lactic Acid); 8558G7RUTR (Pyruvic Acid); OF5P57N2ZX (Alanine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1002/nbm.3656


  10 / 20180 MEDLINE  
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Texto completo SciELO Chile
[PMID]:29189867
[Au] Autor:Quintana F; Pezzani MJ; Orozco R; Dreyse J; Soto L; Regueira T
[Ad] Endereço:Facultad de Medicina, Universidad Finis Terrae, Santiago, Chile.
[Ti] Título:[Metformin-associated lactic acidosis. Report of one case].
[Ti] Título:Acidosis láctica asociada a metformina. Caso clínico..
[So] Source:Rev Med Chil;145(8):1072-1075, 2017 Aug.
[Is] ISSN:0717-6163
[Cp] País de publicação:Chile
[La] Idioma:spa
[Ab] Resumo:Metformin-associated lactic acidosis is a severe and infrequent adverse event. Early diagnosis is essential to start an early treatment, which often has favorable results. We report a 56 years old non-insulin-requiring type 2 diabetic female who developed a severe metabolic acidosis associated with metformin in relation to an acute renal failure secondary to infectious diarrhea. Early treatment with bicarbonate and continuous hemofiltration allowed a quick improvement of the patient. Metformin-associated lactic acidosis has an elevated mortality (50-80%) and has a specific and effective treatment. Therefore, the condition must be born in mind.
[Mh] Termos MeSH primário: Acidose Láctica/induzido quimicamente
Hipoglicemiantes/efeitos adversos
Metformina/efeitos adversos
[Mh] Termos MeSH secundário: Acidose Láctica/terapia
Bicarbonatos/uso terapêutico
Diabetes Mellitus Tipo 2/tratamento farmacológico
Feminino
Hemofiltração/métodos
Seres Humanos
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bicarbonates); 0 (Hypoglycemic Agents); 9100L32L2N (Metformin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE



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