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[PMID]:28457855
[Au] Autor:Tan CW; Sam IC; Chong WL; Lee VS; Chan YF
[Ad] Endereço:Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: tancw86@gmail.com.
[Ti] Título:Polysulfonate suramin inhibits Zika virus infection.
[So] Source:Antiviral Res;143:186-194, 2017 07.
[Is] ISSN:1872-9096
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Zika virus (ZIKV) is an arthropod-borne flavivirus that causes newborn microcephaly and Guillian-Barré syndrome in adults. No therapeutics are available to treat ZIKV infection or other flaviviruses. In this study, we explored the inhibitory effect of glycosaminoglycans and analogues against ZIKV infection. Highly sulfated heparin, dextran sulfate and suramin significantly inhibited ZIKV infection in Vero cells. De-sulfated heparin analogues lose inhibitory effect, implying that sulfonate groups are critical for viral inhibition. Suramin, an FDA-approved anti-parasitic drug, inhibits ZIKV infection with 3-5 log PFU viral reduction with IC value of ∼2.5-5 µg/ml (1.93 µM-3.85 µM). A time-of-drug-addition study revealed that suramin remains potent even when administrated at 1-24 hpi. Suramin inhibits ZIKV infection by preventing viral adsorption, entry and replication. Molecular dynamics simulation revealed stronger interaction of suramin with ZIKV NS3 helicase than with the envelope protein. Suramin warrants further investigation as a potential antiviral candidate for ZIKV infection. Heparan sulfate (HS) is a cellular attachment receptor for multiple flaviviruses. However, no direct ZIKV-heparin interaction was observed in heparin-binding analysis, and downregulate or removal of cellular HS with sodium chlorate or heparinase I/III did not inhibit ZIKV infection. This indicates that cell surface HS is not utilized by ZIKV as an attachment receptor.
[Mh] Termos MeSH primário: Suramina/antagonistas & inibidores
Infecção pelo Zika virus/prevenção & controle
Zika virus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Anticorpos Antivirais
Cercopithecus aethiops
Cloratos/farmacologia
DNA Helicases/metabolismo
Sulfato de Dextrana/antagonistas & inibidores
Flavivirus/efeitos dos fármacos
Glicosaminoglicanos/farmacologia
Heparina/análogos & derivados
Heparina/química
Heparina/farmacologia
Heparitina Sulfato/farmacologia
Concentração Inibidora 50
Camundongos
Simulação de Acoplamento Molecular
Simulação de Dinâmica Molecular
RNA Helicases/química
RNA Helicases/efeitos dos fármacos
Serina Endopeptidases/química
Serina Endopeptidases/efeitos dos fármacos
Suramina/administração & dosagem
Células Vero
Proteínas do Envelope Viral/metabolismo
Proteínas não Estruturais Virais/química
Proteínas não Estruturais Virais/efeitos dos fármacos
Internalização do Vírus/efeitos dos fármacos
Replicação Viral/efeitos dos fármacos
Zika virus/fisiologia
Infecção pelo Zika virus/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Chlorates); 0 (Glycosaminoglycans); 0 (NS3 protein, flavivirus); 0 (Viral Envelope Proteins); 0 (Viral Nonstructural Proteins); 6032D45BEM (Suramin); 9005-49-6 (Heparin); 9042-14-2 (Dextran Sulfate); 9050-30-0 (Heparitin Sulfate); EC 3.4.21.- (Serine Endopeptidases); EC 3.6.4.- (DNA Helicases); EC 3.6.4.13 (RNA Helicases); T95DR77GMR (sodium chlorate)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:29215833
[Au] Autor:Temnov AA; Volkova AG; Melerzanov AV; Novoselov VI
[Ti] Título:[Effect of conditioned medium from mesenchymal stem cells on regeneration of endothelium at HCl-induced damage trachea in rats].
[So] Source:Patol Fiziol Eksp Ter;61(2):28-36, 2017 Apr-Jun.
[Is] ISSN:0031-2991
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The purpose. Respiratory epithelium regeneration is studied in rats with tracheal damage induced by inhaling hydrochloric acid vapor. Method. Regeneration process after the chemical burn was activated by intratracheal administration of preparations obtained from the same-species mesenchymal stem cells (MSC). Results. Tracheal epithelium is shown to recover almost completely on day 3-7 after applying MSC compositions (MSCs). Closed structures containing ciliated cells similar to ciliated cells of the respiratory epithelium lining the trachea are formed in the submucosal epithelium during regeneration. These structures migrate towards epithelium and get incorporated into the damaged epithelium. This phenomenon is apparently indicative of the special mechanism of respiratory epithelium regeneration after HCl-induced injury. Conclusion. It is demonstrated in this study that cell-free MSCs instilled intratracheally promote the recovery of normal submucosal epithelium by either preventing or reducing necrosis and inflammation. Such topical MSCs administration significantly accelerates migration of ciliated cell towards the surface and de novo formation of the ciliary epithelium.
[Mh] Termos MeSH primário: Cloratos/toxicidade
Meios de Cultivo Condicionados/farmacocinética
Células Mesenquimais Estromais
Regeneração/efeitos dos fármacos
Mucosa Respiratória
Traqueia
[Mh] Termos MeSH secundário: Animais
Masculino
Ratos
Ratos Wistar
Mucosa Respiratória/lesões
Mucosa Respiratória/patologia
Mucosa Respiratória/fisiologia
Traqueia/lesões
Traqueia/patologia
Traqueia/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorates); 0 (Culture Media, Conditioned); Z0V9L75H3K (chloric acid)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE


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[PMID]:28505572
[Au] Autor:Tatari K; Gülay A; Thamdrup B; Albrechtsen HJ; Smets BF
[Ad] Endereço:Department of Environmental Engineering, Technical University of Denmark, Miljøvej 113, 2800 Kgs. Lynby, Denmark.
[Ti] Título:Challenges in using allylthiourea and chlorate as specific nitrification inhibitors.
[So] Source:Chemosphere;182:301-305, 2017 Sep.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Allylthiourea (ATU) and chlorate (ClO ) are often used to selectively inhibit nitritation and nitratation. In this work we identified challenges with use of these compounds in inhibitory assays with filter material from a biological rapid sand filter for groundwater treatment. Inhibition was investigated in continuous-flow lab-scale columns, packed with filter material from a full-scale filter and supplied with NH or NO . ATU concentrations of 0.1-0.5 mM interfered with the indophenol blue method for NH quantification leading to underestimation of the measured NH concentration. Interference was stronger at higher ATU levels and resulted in no NH detection at 0.5 mM ATU. ClO at typical concentrations for inhibition assays (1-10 mM) inhibited nitratation by less than 6%, while nitritation was instead inhibited by 91% when NH was supplied. On the other hand, nitratation was inhibited by 67-71% at 10-20 mM ClO when NO was supplied, suggesting significant nitratation inhibition at higher NO concentrations. No chlorite (ClO ) was detected in the effluent, and thus we could not confirm that nitritation inhibition was caused by ClO reduction to ClO . In conclusion, ATU and ClO should be used with caution in inhibition assays, because analytical interference and poor selectivity for the targeted process may affect the experimental outcome and compromise result interpretation.
[Mh] Termos MeSH primário: Cloratos/farmacologia
Nitrificação/efeitos dos fármacos
Tioureia/análogos & derivados
[Mh] Termos MeSH secundário: Compostos de Amônio/análise
Cloratos/química
Cloretos/análise
Filtração
Pesquisa
Tioureia/química
Tioureia/farmacologia
Purificação da Água/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ammonium Compounds); 0 (Chlorates); 0 (Chlorides); 706IDJ14B7 (allylthiourea); GYV9AM2QAG (Thiourea); Z63H374SB6 (chlorite)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE


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[PMID]:28418706
[Au] Autor:Georgiou CD; Zisimopoulos D; Kalaitzopoulou E; Quinn RC
[Ad] Endereço:1 Department of Biology, University of Patras , Patras, Greece .
[Ti] Título:Radiation-Driven Formation of Reactive Oxygen Species in Oxychlorine-Containing Mars Surface Analogues.
[So] Source:Astrobiology;17(4):319-336, 2017 Apr.
[Is] ISSN:1557-8070
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study demonstrates that γ-radiolyzed perchlorate-containing Mars soil salt analogues (in a CO atmosphere) generate upon H O wetting the reactive oxygen species (ROS) superoxide radical (O ), hydrogen peroxide (H O ), and hydroxyl radicals ( OH). This study also validates that analogue radiolysis forms oxychlorine species that, in turn, can UV-photolyze to OH upon UV photolysis. This investigation was made possible by the development of a new assay for inorganic-origin O and H O determination and by the modification of a previous assay for soil OH. Results show that radiolyzed Mg(ClO ) generates H O and OH; and when included as part of a mixture analogous to the salt composition of samples analyzed at the Mars Phoenix site, the analogue generated O , H O , and OH, with OH levels 150-fold higher than in the radiolyzed Mg(ClO ) samples. Radiolyzed Mars Phoenix site salt analogue that did not contain Mg(ClO ) generated only OH also at 150-fold higher concentration than Mg(ClO ) alone. Additionally, UV photolysis of the perchlorate γ radiolysis product chlorite (ClO ) generated the oxychlorine products trihalide (Cl ), chlorine dioxide (ClO ), and hypochlorite (ClO ), with the formation of OH by UV photolysis of ClO . While the generation of ROS may have contributed in part to CO production in the Viking Labeled Release (LR) experiment and O (g) release in the Viking Gas Exchange (GEx) experiment, our results indicate that they are not likely to be the major contributor to the LR and GEx results. However, due to their highly reactive nature, they are expected to play a significant role in the alteration of organics on Mars. Additionally, experiments with hypochlorite show that the thermal stability of NaClO is in the range of the thermal stability observed for thermally liable oxidant responsible for the Viking LR results. Key Words: Mars-Oxygen-Salts-Radiation-Habitability. Astrobiology 17, 319-336.
[Mh] Termos MeSH primário: Cloro/química
Radiação Cósmica
Meio Ambiente Extraterreno
Marte
Espécies Reativas de Oxigênio/química
[Mh] Termos MeSH secundário: Cloratos/química
Peróxido de Hidrogênio/química
Radical Hidroxila/química
Compostos de Magnésio/química
Fotólise
Radiólise de Impulso
Superóxidos/química
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorates); 0 (Magnesium Compounds); 0 (Reactive Oxygen Species); 11062-77-4 (Superoxides); 3352-57-6 (Hydroxyl Radical); 4R7X1O2820 (Chlorine); BBX060AN9V (Hydrogen Peroxide); M536P01U3N (magnesium chlorate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1089/ast.2016.1539


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[PMID]:28319884
[Au] Autor:Ali SN; Ansari FA; Arif H; Mahmood R
[Ad] Endereço:Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, U.P., India.
[Ti] Título:Sodium chlorate induces DNA damage and DNA-protein cross-linking in rat intestine: A dose dependent study.
[So] Source:Chemosphere;177:311-316, 2017 Jun.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Sodium chlorate (NaClO ) is widely used in paper and pulp industries and as a non-selective herbicide. It is also a major by-product generated upon disinfection of drinking water by chlorine dioxide. In this study, we have investigated the genotoxicity of NaClO on the small intestine of rats. Adult male rats were divided into 5 groups: one control and four NaClO treated groups. The NaClO treated groups were given a single acute oral dose of NaClO (100, 250, 500 and 750 mg/kg body weight) and sacrificed 24 h later. Administration of NaClO caused significant DNA damage in a dose dependent manner in the rat intestine. This was evident from the comet assay which showed DNA strand breaks and was further confirmed by agarose gel electrophoresis and release of free nucleotides. Increased DNA protein cross-linking in NaClO administered groups showed formation of a critical lesion which hampers activities of proteins/enzymes involved in DNA repair, transcription and replication. Thus, oral administration of NaClO induces DNA damage in the rat intestine, probably through chlorate induced production of reactive oxygen species.
[Mh] Termos MeSH primário: Cloratos/toxicidade
Dano ao DNA
Reparo do DNA
[Mh] Termos MeSH secundário: Administração Oral
Animais
Peso Corporal
Cloratos/administração & dosagem
Compostos Clorados
Ensaio Cometa
Reagentes para Ligações Cruzadas/química
DNA/química
Desinfecção
Relação Dose-Resposta a Droga
Água Potável
Herbicidas
Intestino Delgado/efeitos dos fármacos
Masculino
Óxidos
Ratos
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorates); 0 (Chlorine Compounds); 0 (Cross-Linking Reagents); 0 (Drinking Water); 0 (Herbicides); 0 (Oxides); 0 (Reactive Oxygen Species); 8061YMS4RM (chlorine dioxide); 9007-49-2 (DNA); T95DR77GMR (sodium chlorate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE


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[PMID]:28130266
[Au] Autor:Ramachandra R; Namburi RB; Dupont ST; Ortega-Martinez O; van Kuppevelt TH; Lindahl U; Spillmann D
[Ad] Endereço:Department of Medical Biochemistry and Microbiology, The Biomedical Center, Uppsala University, Box 582, SE-751 23 Uppsala, Sweden.
[Ti] Título:A potential role for chondroitin sulfate/dermatan sulfate in arm regeneration in Amphiura filiformis.
[So] Source:Glycobiology;27(5):438-449, 2017 May 01.
[Is] ISSN:1460-2423
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Glycosaminoglycans (GAGs), such as chondroitin sulfate (CS) and dermatan sulfate (DS) from various vertebrate and invertebrate sources are known to be involved in diverse cellular mechanisms during repair and regenerative processes. Recently, we have identified CS/DS as the major GAG in the brittlestar Amphiura filiformis, with high proportions of di- and tri-O-sulfated disaccharide units. As this echinoderm is known for its exceptional regeneration capacity, we aimed to explore the role of these GAG chains during A. filiformis arm regeneration. Analysis of CS/DS chains during the regeneration process revealed an increase in the proportion of the tri-O-sulfated disaccharides. Conversely, treatment of A. filiformis with sodium chlorate, a potent inhibitor of sulfation reactions in GAG biosynthesis, resulted in a significant reduction in arm growth rates with total inhibition at concentrations higher than 5 mM. Differentiation was less impacted by sodium chlorate exposure or even slightly increased at 1-2 mM. Based on the structural changes observed during arm regeneration we identified chondroitin synthase, chondroitin-4-O-sulfotransferase 2 and dermatan-4-O-sulfotransferase as candidate genes and sought to correlate their expression with the expression of the A. filiformis orthologue of bone morphogenetic factors, AfBMP2/4. Quantitative amplification by real-time PCR indicated increased expression of chondroitin synthase and chondroitin-4-O-sulfotransferase 2, with a corresponding increase in AfBMP2/4 during regeneration relative to nonregenerating controls. Our findings suggest that proper sulfation of GAGs is important for A. filiformis arm regeneration and that these molecules may participate in mechanisms controlling cell proliferation.
[Mh] Termos MeSH primário: Sulfatos de Condroitina/biossíntese
Dermatan Sulfato/biossíntese
Glicosaminoglicanos/biossíntese
Regeneração/genética
[Mh] Termos MeSH secundário: Animais
Proliferação Celular/genética
Cloratos/farmacologia
Sulfatos de Condroitina/genética
Dermatan Sulfato/genética
Dissacarídeos/genética
Dissacarídeos/metabolismo
Equinodermos/genética
Equinodermos/crescimento & desenvolvimento
Glicosaminoglicanos/genética
Sulfotransferases/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorates); 0 (Disaccharides); 0 (Glycosaminoglycans); 24967-94-0 (Dermatan Sulfate); 9007-28-7 (Chondroitin Sulfates); EC 2.8.- (chondroitin-4-O-sulfotransferase-3); EC 2.8.2.- (Sulfotransferases); EC 2.8.2.- (dermatan-4-sulfotransferase-1); EC 2.8.2.5 (chondroitin 4-sulfotransferase); T95DR77GMR (sodium chlorate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170129
[St] Status:MEDLINE
[do] DOI:10.1093/glycob/cwx010


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[PMID]:28084674
[Au] Autor:Ali SN; Ansari FA; Khan AA; Mahmood R
[Ad] Endereço:Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, 202002, India.
[Ti] Título:Sodium chlorate, a major water disinfection byproduct, alters brush border membrane enzymes, carbohydrate metabolism and impairs antioxidant system of Wistar rat intestine.
[So] Source:Environ Toxicol;32(5):1607-1616, 2017 May.
[Is] ISSN:1522-7278
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sodium chlorate (NaClO ) is a widely used nonselective herbicide. It is also generated as a by-product during disinfection of drinking water by chlorine dioxide. The purpose of this study was to evaluate the effect of NaClO on rat intestine. Adult male rats were randomly divided into five groups: control and remaining four groups were administered orally different doses of NaClO and sacrificed 24 h after the treatment. The administration of NaClO produced acute oxidative stress in the intestine, which manifested in the form of markedly enhanced malondialdehyde levels and carbonyl content and lowered total sulfhydryl groups and glutathione levels. The activities of several brush border membrane (BBM) enzymes were greatly reduced as compared to control. There were alterations in the activities of various enzymes of carbohydrate metabolism and those involved in maintaining the antioxidant defense system. Histological studies support the biochemical results showing NaClO dose-dependent increase in tissue damage. Thus, the present study shows that oral administration of NaClO decreases the activities of BBM enzymes, induces oxidative stress, alters metabolic pathways, and impairs the antioxidant system of rat intestine. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1607-1616, 2017.
[Mh] Termos MeSH primário: Metabolismo dos Carboidratos/efeitos dos fármacos
Cloratos/toxicidade
Intestinos/efeitos dos fármacos
Microvilosidades/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Desinfecção
Herbicidas/toxicidade
Intestinos/enzimologia
Intestinos/metabolismo
Rim/efeitos dos fármacos
Masculino
Microvilosidades/enzimologia
Oxirredução/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Ratos
Ratos Wistar
Testes de Toxicidade
Poluentes Químicos da Água/toxicidade
Purificação da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Chlorates); 0 (Herbicides); 0 (Water Pollutants, Chemical); T95DR77GMR (sodium chlorate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.1002/tox.22388


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[PMID]:27797001
[Au] Autor:Ali SN; Ahmad MK; Mahmood R
[Ad] Endereço:Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, UP, 202002, India.
[Ti] Título:Sodium chlorate, a herbicide and major water disinfectant byproduct, generates reactive oxygen species and induces oxidative damage in human erythrocytes.
[So] Source:Environ Sci Pollut Res Int;24(2):1898-1909, 2017 Jan.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Sodium chlorate (NaClO ) is a widely used non-selective herbicide. It is also generated as a byproduct during disinfection of drinking water by chlorine dioxide. In the present work, the effects of NaClO on human erythrocytes were studied under in vitro conditions. Incubation of erythrocytes with different concentrations of NaClO at 37 °C for 90 min resulted in significant hemolysis. Cell lysates were prepared from NaClO -treated and untreated (control) erythrocytes and assayed for various biochemical parameters. Methemoglobin levels were significantly increased and methemoglobin reductase activity was reduced upon NaClO treatment. There was a significant increase in protein oxidation and lipid peroxidation with a decrease in reduced glutathione and total sulfhydryl content. This suggests the induction of oxidative stress in erythrocytes upon exposure to NaClO . The occurrence of oxidative stress was confirmed by significantly increased generation of reactive oxygen species and lowered antioxidant response of the cells. NaClO treatment also increased nitric oxide levels showing induction of nitrosative stress. The activities of major antioxidant and membrane-bound and metabolic enzymes were significantly altered upon incubation of erythrocytes with NaClO . The erythrocytes became more osmotically fragile while electron microscopic images showed gross morphological alterations in NaClO -treated cells. These results show that NaClO induces oxidative stress in human erythrocytes, which results in extensive membrane damage and lowers the antioxidant response.
[Mh] Termos MeSH primário: Cloratos/toxicidade
Desinfetantes/toxicidade
Eritrócitos/efeitos dos fármacos
Herbicidas/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Eritrócitos/metabolismo
Glutationa/metabolismo
Hemólise/efeitos dos fármacos
Seres Humanos
Peroxidação de Lipídeos/efeitos dos fármacos
Metemoglobina/metabolismo
Oxirredução
Estresse Oxidativo/efeitos dos fármacos
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorates); 0 (Disinfectants); 0 (Herbicides); 0 (Reactive Oxygen Species); 0 (Water Pollutants, Chemical); 9008-37-1 (Methemoglobin); GAN16C9B8O (Glutathione); T95DR77GMR (sodium chlorate)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161101
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-7980-7


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[PMID]:27997392
[Au] Autor:Lakshmanan S; Murugesan T
[Ad] Endereço:University Technology Petronas, Bandar Seri Iskandar, Tronoh, Perak 31750, Malaysia E-mail: lakshmanan.shyam@gmail.com.
[Ti] Título:Adsorption performance of coconut shell activated carbon for the removal of chlorate from chlor-alkali brine stream.
[So] Source:Water Sci Technol;74(12):2819-2831, 2016 Dec.
[Is] ISSN:0273-1223
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Activated carbon from coconut shell was used to investigate the adsorption of chlorate from a chlor-alkali plant's brine stream. The effect of pH, flowrate, chlorate and chloride concentration on the breakthrough curves were studied in small-scale column trials. The results obtained show enhanced adsorption at low flowrates, higher chlorate concentrations, and at a pH of 10. These studies show that introducing an activated carbon adsorption column just before the saturator would remove sufficient quantities of chlorate to allow more of the chlor-alkali plant's brine stream to be reused. From column dynamic studies, the Thomas model showed close approximation when the chlorate in the effluent was higher than breakthrough concentrations and there was close correlation at high influent concentration. The q (maximum adsorption capacity) values were close to those obtained experimentally, indicating close representation of the breakthrough curve by the Thomas model.
[Mh] Termos MeSH primário: Carvão Vegetal/química
Cloratos/isolamento & purificação
Cocos
Eliminação de Resíduos Líquidos/métodos
[Mh] Termos MeSH secundário: Adsorção
Álcalis
Sais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkalies); 0 (Chlorates); 0 (Salts); 0 (brine); 16291-96-6 (Charcoal)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161221
[St] Status:MEDLINE
[do] DOI:10.2166/wst.2016.455


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[PMID]:27791367
[Au] Autor:Smith DJ; Giddings JM; Herges GR; Ernst W
[Ad] Endereço:USDA ARS, Biosciences Research Laboratory , 1605 Albrecht Boulevard, Fargo, North Dakota 58102-2765, United States.
[Ti] Título:Distribution, Identification, and Quantification of Residues after Treatment of Ready-To-Eat Salami with Cl-Labeled or Nonlabeled Chlorine Dioxide Gas.
[So] Source:J Agric Food Chem;64(44):8454-8462, 2016 Nov 09.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:When ready-to-eat salami was treated in a closed system with Cl-labeled ClO (5.5 mg/100 g of salami), essentially all radioactivity was deposited onto the salami. Administered ClO was converted to Cl-chloride ion (>97%), trace levels of chlorate (<2%), and detectable levels of chlorite. In residue studies conducted with nonlabeled ClO , sodium perchlorate residues (LOQ, 4 ng/g) were not formed when reactions were protected from light. Sodium chlorate residues were present in control (39.2 ± 4.8 ng/g) and chlorine dioxide treated (128 ± 31.2 ng/g) salami. If sanitation occurred under conditions of illumination, detectable levels (3.7 ± 1.5 ng/g) of perchlorate were formed along with greater quantities of sodium chlorate (183.6 ± 75.4 ng/g). Collectively, these data suggest that ClO is chemically reduced by salami and that slow-release formulations might be appropriate for applications involving the sanitation of ready-to-eat meat products.
[Mh] Termos MeSH primário: Compostos Clorados/química
Manipulação de Alimentos/métodos
Produtos da Carne
Óxidos/química
[Mh] Termos MeSH secundário: Cloratos/análise
Cloro/análise
Marcação por Isótopo
Percloratos/análise
Radioisótopos/análise
Compostos de Sódio/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorates); 0 (Chlorine Compounds); 0 (Oxides); 0 (Perchlorates); 0 (Radioisotopes); 0 (Sodium Compounds); 4R7X1O2820 (Chlorine); 8061YMS4RM (chlorine dioxide); 97F4MTY3VA (sodium perchlorate); T95DR77GMR (sodium chlorate); VLA4NZX2P4 (perchlorate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE



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