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  1 / 39711 MEDLINE  
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[PMID]:28841529
[Au] Autor:Ghelichpour M; Taheri Mirghaed A; Mirzargar SS; Joshaghani H; Ebrahimzadeh Mousavi H
[Ad] Endereço:Department of Aquatic Animal Health, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
[Ti] Título:Modification of saltwater stress response in Cyprinus carpio (Linnaeus, 1758) pre-exposed to pesticide indoxacarb.
[So] Source:Ecotoxicol Environ Saf;147:139-143, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:To evaluate the effects of indoxacarb on saltwater stress response in Cyprinus carpio, the fish were pre-exposed to indoxacarb (0, 0.75, 1.5 and 3mg/L denoted as CP, 0.75IT, 1.5IT and 3IT, respectively) for 21 days and then released to saltwater. A negative control (CN) group was included (the fish were held in indoxacarb-free water for the entire experiment). The fish were sampled immediately (0h) and 24, 48 and 72h after the salinity exposure for the analysis of plasma cortisol, glucose and sodium, chloride, potassium and calcium levels. All fish pre-exposed to 3mg/L indoxacarb, died after the first day of salinity challenge. CP showed typical cortisol response after the salinity challenge, but, cortisol response of the fish pre-exposed to indoxacarb (0.75IT and 1.5IT) was blocked. Plasma glucose increased significantly in all groups compared to the CN; however, this elevation had no consistent trend in 0.75IT and 1.5IT which indicated interference in glucose response due to indoxacarb exposure. Plasma sodium increased (compared to CN) in all groups after the salinity challenge. However, elevation in plasma chloride and potassium was significantly different among the groups and the indoxacarb-treated fish showed slightly sooner ionic disturbance. The results clearly indicate that indoxacarb impairs stress response of C. carpio and the fish may not be able to respond normally to additional stressors, which threatens their survival.
[Mh] Termos MeSH primário: Carpas/metabolismo
Hidrocortisona/sangue
Osmorregulação/efeitos dos fármacos
Oxazinas/toxicidade
Praguicidas/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Carpas/sangue
Cloretos/sangue
Relação Dose-Resposta a Droga
Potássio/sangue
Salinidade
Sódio/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Oxazines); 0 (Pesticides); 0 (Water Pollutants, Chemical); 52H0D26MWR (indoxacarb); 9NEZ333N27 (Sodium); RWP5GA015D (Potassium); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE


  2 / 39711 MEDLINE  
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[PMID]:27777173
[Au] Autor:Poole DS; Doorenweerd N; Plomp JJ; Mahfouz A; Reinders MJT; van der Weerd L
[Ad] Endereço:Department of Radiology, Leiden University Medical Centre, Leiden, Netherlands. Electronic address: D.Poole@lumc.nl.
[Ti] Título:Continuous infusion of manganese improves contrast and reduces side effects in manganese-enhanced magnetic resonance imaging studies.
[So] Source:Neuroimage;147:1-9, 2017 Feb 15.
[Is] ISSN:1095-9572
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The ability to administer systemically high doses of manganese as contrast agent while circumventing its toxicity is of particular interest for exploratory MRI studies of the brain. Administering low doses either repeatedly or continuously over time has been shown to enable the acquisition of satisfactory MRI images of the mouse brain without apparent side effects. Here we have systematically compared the obtained MRI contrast and recorded potential systemic side effects such as stress response and muscle strength impairment in relation to the achieved contrast. We show in mice that administering MnCl via osmotic infusion pumps allows for a side-effect free delivery of a high cumulative dose of manganese chloride (480mg/kg bodyweight in 8 days). High contrast in MRI was achieved while we did not observe the weight loss or distress seen in other studies where mice received manganese via fractionated intraperitoneal injections of lower doses of manganese. As the normal daily conduct of the mice was not affected, this new manganese delivery method might be of particular use to study brain activity over several days. This may facilitate the phenotyping of new transgenic mouse models, the study of chronic disease models and the monitoring of changes in brain activity in long-term behavioral studies.
[Mh] Termos MeSH primário: Cloretos/administração & dosagem
Cloretos/farmacologia
Meios de Contraste/administração & dosagem
Meios de Contraste/farmacologia
Imagem por Ressonância Magnética/métodos
Compostos de Manganês/administração & dosagem
Compostos de Manganês/farmacologia
[Mh] Termos MeSH secundário: Animais
Cloretos/efeitos adversos
Meios de Contraste/efeitos adversos
Corticosterona/sangue
Aumento da Imagem
Bombas de Infusão
Infusões Intravenosas
Injeções Intraperitoneais
Masculino
Compostos de Manganês/efeitos adversos
Camundongos
Camundongos Endogâmicos C57BL
Força Muscular/efeitos dos fármacos
Estresse Psicológico/induzido quimicamente
Estresse Psicológico/psicologia
Perda de Peso/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Contrast Media); 0 (Manganese Compounds); QQE170PANO (manganese chloride); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  3 / 39711 MEDLINE  
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[PMID]:28460583
[Au] Autor:Nielsen BS; Larsen EH; Ladefoged O; Lam HR
[Ad] Endereço:1 Environment and Toxicology, DHI, Hørsholm, Denmark.
[Ti] Título:Subchronic, Low-Level Intraperitoneal Injections of Manganese (IV) Oxide and Manganese (II) Chloride Affect Rat Brain Neurochemistry.
[So] Source:Int J Toxicol;36(3):239-251, 2017 May/Jun.
[Is] ISSN:1092-874X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Manganese (Mn) is neurotoxic and can induce manganism, a Parkinson-like disease categorized as being a serious central nervous system irreversible neurodegenerative disease. An increased risk of developing symptoms of Parkinson disease has been linked to work-related exposure, for example, for workers in agriculture, horticulture, and people living near areas with frequent use of Mn-containing pesticides. In this study, the focus was placed on neurochemical effects of Mn. Rats were dosed intraperitoneally with 0.9% NaCl (control), 1.22 mg Mn (as MnO )/kg bodyweight (bw)/day, or 2.5 mg Mn (as MnCl )/kg bw/day for 7 d/wk for 8 or 12 weeks. This dosing regimen adds relevant new knowledge about Mn neurotoxicity as a consequence of low-dose subchronic Mn dosing. Manganese concentrations increased in the striatum, the rest of the brain, and in plasma, and regional brain neurotransmitter concentrations, including noradrenaline, dopamine (DA), 5-hydroxytrytamine, glutamate, taurine, and γ-amino butyric acid, and the activity of acetylcholinesterase changed. Importantly, a target parameter for Parkinson disease and manganism, the striatal DA concentration, was reduced after 12 weeks of dosing with MnCl . Plasma prolactin concentration was not significantly affected due to a potentially reduced dopaminergic inhibition of the prolactin release from the anterior hypophysis. No effects on the striatal α-synuclein and synaptophysin protein levels were detected.
[Mh] Termos MeSH primário: Química Encefálica/efeitos dos fármacos
Encéfalo/efeitos dos fármacos
Cloretos/toxicidade
Óxidos/toxicidade
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Animais
Encéfalo/metabolismo
Cloretos/sangue
Cloretos/farmacocinética
Dopamina/metabolismo
Ácido Glutâmico/metabolismo
Injeções Intraperitoneais
Masculino
Manganês/sangue
Manganês/metabolismo
Compostos de Manganês/sangue
Compostos de Manganês/farmacocinética
Norepinefrina/metabolismo
Óxidos/sangue
Óxidos/farmacocinética
Ratos Sprague-Dawley
Serotonina/metabolismo
Taurina/metabolismo
Ácido gama-Aminobutírico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Manganese Compounds); 0 (Oxides); 1EQV5MLY3D (Taurine); 333DO1RDJY (Serotonin); 3KX376GY7L (Glutamic Acid); 42Z2K6ZL8P (Manganese); 56-12-2 (gamma-Aminobutyric Acid); 64J2OA7MH3 (manganese oxide); EC 3.1.1.7 (Acetylcholinesterase); QQE170PANO (manganese chloride); VTD58H1Z2X (Dopamine); X4W3ENH1CV (Norepinephrine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1177/1091581817704378


  4 / 39711 MEDLINE  
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[PMID]:29268102
[Au] Autor:Burgos-Castillo RC; Sirés I; Sillanpää M; Brillas E
[Ad] Endereço:Laboratory of Green Chemistry, School of Engineering Science, Lappeenranta University of Technology, Sammonkatu 12, FI-50130 Mikkeli, Finland. Electronic address: rutely.burgos.castillo@lut.fi.
[Ti] Título:Application of electrochemical advanced oxidation to bisphenol A degradation in water. Effect of sulfate and chloride ions.
[So] Source:Chemosphere;194:812-820, 2018 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Electrochemical oxidation with electrogenerated H O (EO- H O ), electro-Fenton (EF), photoelectro-Fenton (PEF) and solar PEF (SPEF) have been applied to mineralize bisphenol A solutions in 0.050 M Na SO or 0.008 M NaCl + 0.047 M Na SO at pH 3.0. The assays were performed in an undivided cell with a boron-doped diamond (BDD) anode and an air-diffusion cathode for continuous H O production. The PEF and SPEF processes yielded almost total mineralization due to the potent synergistic action of generated hydroxyl radicals and active chlorine, in conjunction with the photolytic action of UV radiation. The higher intensity of UV rays from sunlight explained the superior oxidation ability of SPEF. The effect of applied current density was studied in all treatments, whereas the role of bisphenol A concentration was examined in PEF. Bisphenol A abatement followed a pseudo-first-order kinetics, which was very quick in SPEF since UV light favored a large production of hydroxyl radicals from Fenton's reaction. Eight non-chlorinated and six chlorinated aromatics were identified as primary products in the chloride matrix. Ketomalonic, tartronic, maleic and oxalic acids were detected as final short-chain aliphatic carboxylic acids. The large stability of Fe(III)-oxalate complexes in EF compared to their fast photomineralization in PEF and PEF accounted for by the superior oxidation power of the latter processes.
[Mh] Termos MeSH primário: Compostos Benzidrílicos/química
Cloretos/farmacologia
Técnicas Eletroquímicas/métodos
Fenóis/química
Fotólise
Sulfatos/farmacologia
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Peróxido de Hidrogênio/química
Radical Hidroxila/química
Ferro/química
Oxirredução
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Chlorides); 0 (Phenols); 0 (Sulfates); 0 (Water Pollutants, Chemical); 3352-57-6 (Hydroxyl Radical); BBX060AN9V (Hydrogen Peroxide); E1UOL152H7 (Iron); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


  5 / 39711 MEDLINE  
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[PMID]:29360848
[Au] Autor:Liu Z; Zhu J; Yang X; Wu H; Wei Q; Wei H; Zhang H
[Ad] Endereço:Research Center of Saline and Alkali Land of State Forestry Administration, Chinese Academy of Forestry, Beijing, P. R. China.
[Ti] Título:Growth performance, organ-level ionic relations and organic osmoregulation of Elaeagnus angustifolia in response to salt stress.
[So] Source:PLoS One;13(1):e0191552, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Elaeagnus angustifolia is one of the most extensively afforested tree species in environment-harsh regions of northern China. Despite its exceptional tolerance to saline soil, the intrinsic adaptive physiology has not been revealed. In this study, we investigated the growth, organ-level ionic relations and organic osmoregulation of the seedlings hydroponically treated with 0, 100 and 200 mM NaCl for 30 days. We found that the growth characteristics and the whole-plant dry weight were not obviously stunted, but instead, were even slightly stimulated by the treatment of 100 mM NaCl. In contrast, these traits were significantly inhibited by 200 mM NaCl treatment. Interestingly, as compared with the control (0 mM NaCl), both 100 and 200 mM NaCl treatments had a promotional effect on root growth as evidenced by 26.3% and 2.4% increases in root dry weight, respectively. Roots had the highest Na+ and Cl- concentrations and obviously served as the sink for the net increased Na+ and Cl-, while, stems might maintain the capacity of effective Na+ constraint, resulting in reduced Na+ transport to the leaves. K+, Ca2+ and Mg2+ concentrations in three plant organs of NaCl-treated seedlings presented a substantial decline, eventually leading to an enormously drop of K+/Na+ ratio. As the salt concentration increased, proline and soluble protein contents continuously exhibited a prominent and a relatively tardy accumulation, respectively, whereas soluble sugar firstly fell to a significant level and then regained to a level that is close to that of the control. Taken together, our results provided quantitative measures that revealed some robust adaptive physiological mechanisms underpinning E. angustifolia's moderately high salt tolerance, and those mechanisms comprise scalable capacity for root Na+ and Cl- storage, effectively constrained transportation of Na+ from stems to leaves, root compensatory growth, as well as an immediate and prominent leaf proline accumulation.
[Mh] Termos MeSH primário: Elaeagnaceae/efeitos dos fármacos
Osmorregulação
Cloreto de Sódio/farmacologia
Estresse Fisiológico
[Mh] Termos MeSH secundário: Adaptação Fisiológica
Cloretos/metabolismo
Elaeagnaceae/crescimento & desenvolvimento
Elaeagnaceae/fisiologia
Transporte de Íons
Folhas de Planta/metabolismo
Raízes de Plantas/metabolismo
Potássio/metabolismo
Plântulas/metabolismo
Sódio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chlorides); 451W47IQ8X (Sodium Chloride); 9NEZ333N27 (Sodium); RWP5GA015D (Potassium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191552


  6 / 39711 MEDLINE  
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[PMID]:29297909
[Au] Autor:Katayama K; Furutani Y; Iwaki M; Fukuda T; Imai H; Kandori H
[Ad] Endereço:Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya 466-8555, Japan. kandori@nitech.ac.jp.
[Ti] Título:"In situ" observation of the role of chloride ion binding to monkey green sensitive visual pigment by ATR-FTIR spectroscopy.
[So] Source:Phys Chem Chem Phys;20(5):3381-3387, 2018 Jan 31.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Long-wavelength-sensitive (LWS) pigment possesses a chloride binding site in its protein moiety. The binding of chloride alters the absorption spectra of LWS; this is known as the chloride effect. Although the two amino acid substitutions of His197 and Lys200 influence the chloride effect, the molecular mechanism of chloride binding, which underlies the spectral tuning, has yet to be clarified. In this study, we applied ATR-FTIR spectroscopy to monkey green (MG) pigment to gain structural information of the chloride binding site. The results suggest that chloride binding stabilizes the ß-sheet structure on the extracellular side loop with perturbation of the retinal polyene chain, promotes a hydrogen bonding exchange with the hydroxyl group of Tyr, and alters the protonation state of carboxylate. Combining with the results of the binding analyses of various anions (Br , I and NO ), our findings suggest that the anion binding pocket is organized for only Cl (or Br ) to stabilize conformation around the retinal chromophore, which is functionally relevant with absorbing long wavelength light.
[Mh] Termos MeSH primário: Cloretos/química
Pigmentos da Retina/química
[Mh] Termos MeSH secundário: Animais
Ânions/química
Sítios de Ligação
Cercopithecus aethiops
Cloretos/metabolismo
Células HEK293
Seres Humanos
Ligações de Hidrogênio
Estrutura Secundária de Proteína
Proteínas Recombinantes/biossíntese
Proteínas Recombinantes/química
Proteínas Recombinantes/isolamento & purificação
Pigmentos da Retina/genética
Pigmentos da Retina/metabolismo
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anions); 0 (Chlorides); 0 (Recombinant Proteins); 0 (Retinal Pigments)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.1039/c7cp07277e


  7 / 39711 MEDLINE  
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[PMID]:29173354
[Au] Autor:Feldman M; Dickson B
[Ad] Endereço:Department of Internal Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas. Electronic address: MarkFeldman@TexasHealth.org.
[Ti] Título:Plasma Electrolyte Distributions in Humans-Normal or Skewed?
[So] Source:Am J Med Sci;354(5):453-457, 2017 11.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: It is widely believed that plasma electrolyte levels are normally distributed. Statistical tests and calculations using plasma electrolyte data are often reported based on this assumption of normality. Examples include t tests, analysis of variance, correlations and confidence intervals. The purpose of our study was to determine whether plasma sodium (Na ), potassium (K ), chloride (Cl ) and bicarbonate [Formula: see text] distributions are indeed normally distributed. METHODS: We analyzed plasma electrolyte data from 237 consecutive adults (137 women and 100 men) who had normal results on a standard basic metabolic panel which included plasma electrolyte measurements. The skewness of each distribution (as a measure of its asymmetry) was compared to the zero skewness of a normal (Gaussian) distribution. RESULTS: The plasma Na distribution was skewed slightly to the right, but the skew was not significantly different from zero skew. The plasma Cl distribution was skewed slightly to the left, but again the skew was not significantly different from zero skew. On the contrary, both the plasma K and [Formula: see text] distributions were significantly skewed to the right (P < 0.01 zero skew). There was also a suggestion from examining frequency distribution curves that K and [Formula: see text] distributions were bimodal. CONCLUSIONS: In adults with a normal basic metabolic panel, plasma potassium and bicarbonate levels are not normally distributed and may be bimodal. Thus, statistical methods to evaluate these 2 plasma electrolytes should be nonparametric tests and not parametric ones that require a normal distribution.
[Mh] Termos MeSH primário: Eletrólitos/sangue
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Bicarbonatos/sangue
Cloretos/sangue
Feminino
Seres Humanos
Masculino
Meia-Idade
Potássio/sangue
Sódio/sangue
Distribuições Estatísticas
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bicarbonates); 0 (Chlorides); 0 (Electrolytes); 9NEZ333N27 (Sodium); RWP5GA015D (Potassium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  8 / 39711 MEDLINE  
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[PMID]:28743592
[Au] Autor:Cronin AA; Odagiri M; Arsyad B; Nuryetty MT; Amannullah G; Santoso H; Darundiyah K; Nasution N'
[Ad] Endereço:UNICEF Indonesia, World Trade Center 6 (10th Floor), Jalan Jenderal Sudirman Kav. 31, Jakarta 12920, Indonesia. Electronic address: acronin@unicef.org.
[Ti] Título:Piloting water quality testing coupled with a national socioeconomic survey in Yogyakarta province, Indonesia, towards tracking of Sustainable Development Goal 6.
[So] Source:Int J Hyg Environ Health;220(7):1141-1151, 2017 10.
[Is] ISSN:1618-131X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:There remains a pressing need for systematic water quality monitoring strategies to assess drinking water safety and to track progress towards the Sustainable Development Goals (SDG). This study incorporated water quality testing into an existing national socioeconomic survey in Yogyakarta province, Indonesia; the first such study in Indonesia in terms of SDG tracking. Multivariate regression analysis assessed the association between faecal and nitrate contamination and drinking water sources household drinking water adjusted for wealth, education level, type of water sources and type of sanitation facilities. The survey observed widespread faecal contamination in both sources for drinking water (89.2%, 95%CI: 86.9-91.5%; n=720) and household drinking water (67.1%, 95%CI: 64.1-70.1%; n=917) as measured by Escherichia coli. This was despite widespread improved drinking water source coverage (85.3%) and commonly self-reported boiling practices (82.2%). E.coli concentration levels in household drinking water were associated with wealth, education levels of a household head, and type of water source (i.e. vender water or local sources). Following the proposed SDG definition for Target 6.1 (water) and 6.2 (sanitation), the estimated proportion of households with access to safely managed drinking water and sanitation was 8.5% and 45.5%, respectively in the study areas, indicating substantial difference from improved drinking water (82.2%) and improved sanitation coverage (70.9%) as per the MDGs targets. The greatest contamination and risk factors were found in the poorest households indicating the urgent need for targeted and effective interventions here. There is suggested evidence that sub-surface leaching from on-site sanitation adversely impacts on drinking water sources, which underscores the need for further technical assistance in promoting latrine construction. Urgent action is still needed to strengthen systematic monitoring efforts towards tracking SDG Goal 6.
[Mh] Termos MeSH primário: Água Potável/microbiologia
Escherichia coli/isolamento & purificação
Poluentes Químicos da Água/análise
Qualidade da Água
[Mh] Termos MeSH secundário: Cloretos/análise
Conservação dos Recursos Naturais
Água Potável/análise
Fezes/microbiologia
Metas
Seres Humanos
Indonésia
Nitratos/análise
Pobreza
Análise de Regressão
Saneamento/métodos
Fatores Socioeconômicos
Inquéritos e Questionários
Microbiologia da Água
Abastecimento de Água
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chlorides); 0 (Drinking Water); 0 (Nitrates); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


  9 / 39711 MEDLINE  
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[PMID]:29293656
[Au] Autor:Novotny J; Chandraratne S; Weinberger T; Philippi V; Stark K; Ehrlich A; Pircher J; Konrad I; Oberdieck P; Titova A; Hoti Q; Schubert I; Legate KR; Urtz N; Lorenz M; Pelisek J; Massberg S; von Brühl ML; Schulz C
[Ad] Endereço:Medizinische Klinik und Poliklinik I, Ludwig-Maximilians-Universität, Munich, Germany.
[Ti] Título:Histological comparison of arterial thrombi in mice and men and the influence of Cl-amidine on thrombus formation.
[So] Source:PLoS One;13(1):e0190728, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIMS: Medical treatment of arterial thrombosis is mainly directed against platelets and coagulation factors, and can lead to bleeding complications. Novel antithrombotic therapies targeting immune cells and neutrophil extracellular traps (NETs) are currently being investigated in animals. We addressed whether immune cell composition of arterial thrombi induced in mouse models of thrombosis resemble those of human patients with acute myocardial infarction (AMI). METHODS AND RESULTS: In a prospective cohort study of patients suffering from AMI, 81 human arterial thrombi were harvested during percutaneous coronary intervention and subjected to detailed histological analysis. In mice, arterial thrombi were induced using two distinct experimental models, ferric chloride (FeCl3) and wire injury of the carotid artery. We found that murine arterial thrombi induced by FeCl3 were highly concordant with human coronary thrombi regarding their immune cell composition, with neutrophils being the most abundant cell type, as well as the presence of NETs and coagulation factors. Pharmacological treatment of mice with the protein arginine deiminase (PAD)-inhibitor Cl-amidine abrogated NET formation, reduced arterial thrombosis and limited injury in a model of myocardial infarction. CONCLUSIONS: Neutrophils are a hallmark of arterial thrombi in patients suffering from acute myocardial infarction and in mouse models of arterial thrombosis. Inhibition of PAD could represent an interesting strategy for the treatment of arterial thrombosis to reduce neutrophil-associated tissue damage and improve functional outcome.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Infarto do Miocárdio/patologia
Ornitina/análogos & derivados
Trombose/patologia
[Mh] Termos MeSH secundário: Idoso
Animais
Cloretos/administração & dosagem
Vasos Coronários/patologia
Feminino
Compostos Férricos/administração & dosagem
Seres Humanos
Masculino
Camundongos
Meia-Idade
Ornitina/farmacologia
Estudos Prospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chlorides); 0 (Ferric Compounds); 0 (N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide); E524N2IXA3 (Ornithine); U38V3ZVV3V (ferric chloride)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190728


  10 / 39711 MEDLINE  
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[PMID]:28458145
[Au] Autor:Bischin C; Mot A; Stefancu A; Leopold N; Hathazi D; Damian G; Silaghi-Dumitrescu R
[Ad] Endereço:Department of Chemistry, Babes-Bolyai University, 11 Arany Janos Street, Cluj-Napoca 400028, Romania.
[Ti] Título:Chlorite reactivity with myoglobin: Analogy with peroxide and nitrite chemistry?
[So] Source:J Inorg Biochem;172:122-128, 2017 Jul.
[Is] ISSN:1873-3344
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Stopped-flow UV-vis data allow for the first time direct spectroscopic detection of a ferryl species during the reaction of met myoglobin (Mb) with chlorite, analogous to what is observed in the reaction with peroxides. Ferryl is also observed in the reaction of oxy Mb+chlorite. A pathway involving Fe-O-O-ClO is explored by analogy with the Fe-O-O-NO and Fe-O-O-NO previously proposed as intermediates in the reactions of oxy globins with nitric oxide and nitrite, respectively. However, Fe-O-O-ClO is not detectable in these stopped-flow experiments and is in fact, unlike its nitrogenous congeners, predicted by density functional theory (DFT) to be impossible for a heme complex. Deoxy Mb reacts with chlorite faster than met - suggesting that, unlike with hydrogen peroxide (with which deoxy Mb reacts slower than met), binding of chlorite to the heme is not a rate-determining step (hence, most likely, an outer-sphere electron transfer mechanism); to correlate this, a Fe-O-Cl-O adduct was not observed experimentally for the met or for the deoxy reactions - even though prior DFT calculations suggest it to be feasible and detectable.
[Mh] Termos MeSH primário: Cloretos/química
Mioglobina/química
Nitritos/química
Peróxidos/química
Teoria Quântica
[Mh] Termos MeSH secundário: Heme/química
Modelos Químicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Myoglobin); 0 (Nitrites); 0 (Peroxides); 42VZT0U6YR (Heme); Z63H374SB6 (chlorite)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE



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