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  1 / 2704 MEDLINE  
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[PMID]:28866974
[Au] Autor:Hammond NE; Bellomo R; Gallagher M; Gattas D; Glass P; Mackle D; Micallef S; Myburgh J; Saxena M; Taylor C; Young P; Finfer S
[Ad] Endereço:Critical Care and Trauma Division, The George Institute for Global Health, Sydney, NSW, Australia.
[Ti] Título:The Plasma-Lyte 148 v Saline (PLUS) study protocol: a multicentre, randomised controlled trial of the effect of intensive care fluid therapy on mortality.
[So] Source:Crit Care Resusc;19(3):239-246, 2017 Sep.
[Is] ISSN:1441-2772
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: 0.9% sodium chloride (saline) is the most commonly administered resuscitation fluid on a global basis but emerging evidence suggests that its high chloride content may have important adverse effects. OBJECTIVE: To describe the study protocol for the Plasma- Lyte 148 v Saline study, which will test the hypothesis that in critically ill adult patients the use of Plasma-Lyte 148 (a buffered crystalloid solution) for fluid therapy results in different 90-day all-cause mortality when compared with saline. DESIGN AND SETTING: We will conduct this multicentre, blinded, randomised controlled trial in approximately 50 intensive care units in Australia and New Zealand. We will randomly assign 8800 patients to either Plasma-Lyte 148 or saline for all resuscitation fluid, maintenance fluid and compatible drug dilution therapy while in the ICU for up to 90 days after randomisation. OUTCOME MEASURES: The primary outcome is 90-day all-cause mortality; secondary outcomes include mean and peak creatinine concentration, incidence of renal replacement therapy, incidence and duration of vasoactive drug treatment, duration of mechanical ventilation, ICU and hospital length of stay, and quality of life and health services use at 6 months. RESULTS AND CONCLUSIONS: The PLUS study will provide high-quality data on the comparative safety and efficacy of Plasma-Lyte 148 compared with saline for resuscitation and compatible crystalloid fluid therapy in critically ill adult patients.
[Mh] Termos MeSH primário: Estado Terminal/terapia
Hidratação/métodos
Cloreto de Sódio/uso terapêutico
[Mh] Termos MeSH secundário: Austrália
Creatinina/metabolismo
Estado Terminal/mortalidade
Gluconatos/uso terapêutico
Serviços de Saúde/utilização
Seres Humanos
Unidades de Terapia Intensiva
Tempo de Internação
Cloreto de Magnésio/uso terapêutico
Mortalidade
Nova Zelândia
Cloreto de Potássio/uso terapêutico
Qualidade de Vida
Terapia de Substituição Renal/utilização
Respiração Artificial
Ressuscitação
Acetato de Sódio/uso terapêutico
Fatores de Tempo
Vasoconstritores/uso terapêutico
Vasodilatadores/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Gluconates); 0 (Plasma-lyte 148); 0 (Vasoconstrictor Agents); 0 (Vasodilator Agents); 02F3473H9O (Magnesium Chloride); 451W47IQ8X (Sodium Chloride); 4550K0SC9B (Sodium Acetate); 660YQ98I10 (Potassium Chloride); AYI8EX34EU (Creatinine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE


  2 / 2704 MEDLINE  
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[PMID]:28657310
[Au] Autor:Gong Z; Sun H
[Ad] Endereço:School of Chemistry and Chemical Engineering and Ministry of Education Key Laboratory of Scientific and Engineering Computing, Shanghai Jiao Tong University , Shanghai, 200240, China.
[Ti] Título:A Coarse-Grained Force Field Parameterized for MgCl and CaCl Aqueous Solutions.
[So] Source:J Chem Inf Model;57(7):1599-1608, 2017 Jul 24.
[Is] ISSN:1549-960X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Calcium and magnesium ions play important roles in many physicochemical processes. To facilitate the investigation of phenomena related to these ions that occur over large length and time scales, a coarse-grained force field (CGFF) is developed for MgCl and CaCl aqueous solutions. The ions are modeled by CG beads with characteristics of hydration shells. To accurately describe the nonideal behavior of the solutions, osmotic coefficients in a wide range of concentrations were used as guidance for parametrization. The osmotic coefficients were obtained from the chemical potential increments of water calculated using the Bennett acceptance ratio (BAR) method. The result CGFF accurately reproduces experimental osmotic coefficients, densities, surface tensions, and cation-anion separations of calcium chloride and magnesium chloride solutions at molalities up to 3.0 mol/kg. As a preliminary application, the force field is applied to simulate aggregations of sodium dodecyl sulfate (SDS) in calcium chloride solution, and the simulation results are consistent with experimental observations.
[Mh] Termos MeSH primário: Cloreto de Cálcio/química
Cloreto de Magnésio/química
Modelos Moleculares
Água/química
[Mh] Termos MeSH secundário: Conformação Molecular
Soluções
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Solutions); 02F3473H9O (Magnesium Chloride); 059QF0KO0R (Water); M4I0D6VV5M (Calcium Chloride)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jcim.7b00206


  3 / 2704 MEDLINE  
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[PMID]:28654669
[Au] Autor:Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C
[Ad] Endereço:Center for Clinical and Translational Science, University of Vermont, Burlington, Vermont, United States of America.
[Ti] Título:Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
[So] Source:PLoS One;12(6):e0180067, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Current treatment options for depression are limited by efficacy, cost, availability, side effects, and acceptability to patients. Several studies have looked at the association between magnesium and depression, yet its role in symptom management is unclear. The objective of this trial was to test whether supplementation with over-the-counter magnesium chloride improves symptoms of depression. An open-label, blocked, randomized, cross-over trial was carried out in outpatient primary care clinics on 126 adults (mean age 52; 38% male) diagnosed with and currently experiencing mild-to-moderate symptoms with Patient Health Questionnaire-9 (PHQ-9) scores of 5-19. The intervention was 6 weeks of active treatment (248 mg of elemental magnesium per day) compared to 6 weeks of control (no treatment). Assessments of depression symptoms were completed at bi-weekly phone calls. The primary outcome was the net difference in the change in depression symptoms from baseline to the end of each treatment period. Secondary outcomes included changes in anxiety symptoms as well as adherence to the supplement regimen, appearance of adverse effects, and intention to use magnesium supplements in the future. Between June 2015 and May 2016, 112 participants provided analyzable data. Consumption of magnesium chloride for 6 weeks resulted in a clinically significant net improvement in PHQ-9 scores of -6.0 points (CI -7.9, -4.2; P<0.001) and net improvement in Generalized Anxiety Disorders-7 scores of -4.5 points (CI -6.6, -2.4; P<0.001). Average adherence was 83% by pill count. The supplements were well tolerated and 61% of participants reported they would use magnesium in the future. Similar effects were observed regardless of age, gender, baseline severity of depression, baseline magnesium level, or use of antidepressant treatments. Effects were observed within two weeks. Magnesium is effective for mild-to-moderate depression in adults. It works quickly and is well tolerated without the need for close monitoring for toxicity.
[Mh] Termos MeSH primário: Antidepressivos/uso terapêutico
Transtorno Depressivo/tratamento farmacológico
Cloreto de Magnésio/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos Cross-Over
Feminino
Seres Humanos
Masculino
Meia-Idade
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antidepressive Agents); 02F3473H9O (Magnesium Chloride)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180067


  4 / 2704 MEDLINE  
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[PMID]:28651514
[Au] Autor:Zampieri FG; Azevedo LCP; Corrêa TD; Falavigna M; Machado FR; Assunção MSC; Lobo SMA; Dourado LK; Berwanger O; Kellum JA; Brandão N; Cavalcanti AB; BaSICS Investigators and the BRICNet
[Ad] Endereço:Research Institute HCor, Hospital of Coração, São Paulo, Brazil. abiasi@hcor.com.br.
[Ti] Título:Study protocol for the Balanced Solution versus Saline in Intensive Care Study (BaSICS): a factorial randomised trial.
[So] Source:Crit Care Resusc;19(2):175-182, 2017 Jun.
[Is] ISSN:1441-2772
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The effectiveness and safety of balanced crystalloid fluids compared with saline (0.9% sodium chloride) as a fluid of choice in critically ill patients remain unclear. The effects of different fluid infusion rates on outcomes are also unknown. OBJECTIVES: To test the hypothesis that a balanced crystalloid solution, compared with saline, decreases 90-day all-cause mortality among critically ill patients; and to test the hypothesis that slow, compared with rapid, infusion rate decreases 90-day mortality in this population of patients. METHODS: The Balanced Solution versus Saline in Intensive Care Study (BaSICS) is a pragmatic, 2 ??2 factorial, randomised controlled trial. A total of 11 000 patients will be recruited from at least 100 Brazilian intensive care units. Patients will be randomised to receive Plasma-Lyte 148 or saline, and to rapid infusion (999 mL/h) or slow infusion (333 mL/h). Study fluids will be used for resuscitation episodes (at rapid or slow infusion rates), dilution of compatible medications and maintenance solutions. Patients, health care providers and investigators will be blinded to the solutions being tested. The rate of bolus infusion will not be blinded. OUTCOMES: The primary outcome is 90-day all-cause mortality. Secondary outcomes are: incidence of renal failure requiring renal replacement therapy within 90 days, incidence of acute kidney injury (Kidney Disease: Improving Global Outcomes stages 2 and 3), incidence of non-renal organ dysfunction assessed by Sepsis-related Organ Failure Assessment score at Days 3 and 7, and number of mechanical ventilationfree days within the first 28 days after randomisation. RESULTS AND CONCLUSIONS: The BaSICS trial will provide robust evidence on whether a balanced crystalloid, compared with saline, improves important patient outcomes in critically ill patients. BaSICS will also provide relevant information on whether bolus infusion rate affects outcomes in this population. TRIAL REGISTRATION: ClinicalTrials.gov NCT02875873.
[Mh] Termos MeSH primário: Estado Terminal/mortalidade
Estado Terminal/terapia
Hidratação/métodos
Unidades de Terapia Intensiva
Cloreto de Sódio/administração & dosagem
[Mh] Termos MeSH secundário: Idoso
Brasil
Causas de Morte
Método Duplo-Cego
Gluconatos/administração & dosagem
Mortalidade Hospitalar
Seres Humanos
Infusões Intravenosas/métodos
Cloreto de Magnésio/administração & dosagem
Seleção de Pacientes
Cloreto de Potássio/administração & dosagem
Projetos de Pesquisa
Acetato de Sódio/administração & dosagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Gluconates); 0 (Plasma-lyte 148); 02F3473H9O (Magnesium Chloride); 451W47IQ8X (Sodium Chloride); 4550K0SC9B (Sodium Acetate); 660YQ98I10 (Potassium Chloride)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE


  5 / 2704 MEDLINE  
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[PMID]:28581718
[Au] Autor:Lu X; Fan L; Phelps CB; Davie CP; Donahue CP
[Ad] Endereço:GlaxoSmithKline, Platform Technology & Science, Drug Discovery and Selection, New Chemical Entity Molecular Discovery, Encoded Library Technologies , 830 Winter Street, Waltham, Massachusetts 02451, United States.
[Ti] Título:Ruthenium Promoted On-DNA Ring-Closing Metathesis and Cross-Metathesis.
[So] Source:Bioconjug Chem;28(6):1625-1629, 2017 Jun 21.
[Is] ISSN:1520-4812
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:DNA-encoded library technology (ELT) is now widely used in pharmaceutical, biotechnological, and academic research for hit identification and target validation. New on-DNA reactions are keys to exploring greater chemical space and accessing challenging chemotypes such as configurationally constrained macrocycles. Herein, we describe the first on-DNA ring-closing metathesis (RCM) and cross-metathesis (CM) reactions promoted by fast initiating Grubbs Ru reagents. Under the optimized conditions, MgCl was used to protect the DNA from Ru-induced decomposition. The substrate scope for on-DNA RCM was established and the same conditions were applied to a CM reaction with good conversion.
[Mh] Termos MeSH primário: DNA/química
Rutênio/química
[Mh] Termos MeSH secundário: Ciclização
Cloreto de Magnésio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
02F3473H9O (Magnesium Chloride); 7UI0TKC3U5 (Ruthenium); 9007-49-2 (DNA)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.1021/acs.bioconjchem.7b00292


  6 / 2704 MEDLINE  
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[PMID]:28356528
[Au] Autor:Bujalowski PJ; Bujalowski W; Choi KH
[Ad] Endereço:Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch, Galveston, Texas, USA.
[Ti] Título:Interactions between the Dengue Virus Polymerase NS5 and Stem-Loop A.
[So] Source:J Virol;91(11), 2017 Jun 01.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The process of RNA replication by dengue virus is still not completely understood despite the significant progress made in the last few years. Stem-loop A (SLA), a part of the viral 5' untranslated region (UTR), is critical for the initiation of dengue virus replication, but quantitative analysis of the interactions between the dengue virus polymerase NS5 and SLA in solution has not been performed. Here, we examine how solution conditions affect the size and shape of SLA and the formation of the NS5-SLA complex. We show that dengue virus NS5 binds SLA with a 1:1 stoichiometry and that the association reaction is primarily entropy driven. We also observe that the NS5-SLA interaction is influenced by the magnesium concentration in a complex manner. Binding is optimal with 1 mM MgCl but decreases with both lower and higher magnesium concentrations. Additionally, data from a competition assay between SLA and single-stranded RNA (ssRNA) indicate that SLA competes with ssRNA for the same binding site on the NS5 polymerase. SLA and SLA , which contain the first 70 and 80 nucleotides (nt), respectively, bind NS5 with similar binding affinities. Dengue virus NS5 also binds SLAs from different serotypes, indicating that NS5 recognizes the overall shape of SLA as well as specific nucleotides. Dengue virus is an important human pathogen responsible for dengue hemorrhagic fever, whose global incidence has increased dramatically over the last several decades. Despite the clear medical importance of dengue virus infection, the mechanism of viral replication, a process commonly targeted by antiviral therapeutics, is not well understood. In particular, stem-loop A (SLA) and stem-loop B (SLB) located in the 5' untranslated region (UTR) are critical for binding the viral polymerase NS5 to initiate minus-strand RNA synthesis. However, little is known regarding the kinetic and thermodynamic parameters driving these interactions. Here, we quantitatively examine the energetics of intrinsic affinities, characterize the stoichiometry of the complex of NS5 and SLA, and determine how solution conditions such as magnesium and sodium concentrations and temperature influence NS5-SLA interactions in solution. Quantitatively characterizing dengue virus NS5-SLA interactions will facilitate the design and assessment of antiviral therapeutics that target this essential step of the dengue virus life cycle.
[Mh] Termos MeSH primário: Regiões 5´ não Traduzidas/fisiologia
Vírus da Dengue/fisiologia
Sequências Repetidas Invertidas
Proteínas não Estruturais Virais/metabolismo
[Mh] Termos MeSH secundário: Regiões 5' não Traduzidas/efeitos dos fármacos
Regiões 5' não Traduzidas/genética
Sítios de Ligação/efeitos dos fármacos
Linhagem Celular
Dengue
Vírus da Dengue/genética
Entropia
Seres Humanos
Cloreto de Magnésio/farmacologia
Regiões Promotoras Genéticas
RNA Viral/genética
Sorogrupo
Proteínas não Estruturais Virais/química
Ligação Viral/efeitos dos fármacos
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (5' Untranslated Regions); 0 (NS5 protein, dengue virus); 0 (RNA, Viral); 0 (Viral Nonstructural Proteins); 02F3473H9O (Magnesium Chloride)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171112
[Lr] Data última revisão:
171112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE


  7 / 2704 MEDLINE  
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[PMID]:28299593
[Au] Autor:Chatterjee R; Kolli V; Sarkar N
[Ad] Endereço:Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Rourkela, Odisha, 769008, India.
[Ti] Título:Trehalose and Magnesium Chloride Exert a Common Anti-amyloidogenic Effect Towards Hen Egg White Lysozyme.
[So] Source:Protein J;36(2):138-146, 2017 Apr.
[Is] ISSN:1875-8355
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Many degenerative disorder such as Parkinsons, Alzheimers, Huntingtons disease, etc are caused due to the deposition of amyloid fibrils, formed due to the ordered aggregation of misfolded/unfolded proteins. Misfolded or unfolded proteins aggregate mostly through hydrophobic interactions which are unexposed in native state, but become exposed upon unfolding. To counteract amyloid related diseases, inhibition of the protein self assembly into fibril is a potential therapeutic strategy. The study aims at investigating the effect of selected compounds, namely trehalose and magnesium chloride hexahydrate towards inhibition and disaggregation of amyloid fibrils using Hen Egg White Lysozyme as a model. We further attempted to understand the mechanism of action with the help of various biophysical, microscopic as well as computational studies. A common mechanism of action was identified where the selected compounds exert their anti-amyloidogenic effects by altering HEWL conformations characterized by reduction in the beta sheet content and decrease in exposed hydrophobic surfaces. The altered conformation seems to have lesser amyloidogenic propensity leading to inhibition as well as disaggregation of amyloids.
[Mh] Termos MeSH primário: Amiloide/antagonistas & inibidores
Cloreto de Magnésio/farmacologia
Muramidase/química
Trealose/metabolismo
Trealose/farmacologia
[Mh] Termos MeSH secundário: Amiloide/química
Amiloide/metabolismo
Interações Hidrofóbicas e Hidrofílicas
Cloreto de Magnésio/química
Cloreto de Magnésio/metabolismo
Microscopia Eletrônica de Transmissão
Modelos Moleculares
Simulação de Acoplamento Molecular
Muramidase/metabolismo
Conformação Proteica
Dobramento de Proteína
Estrutura Secundária de Proteína
Trealose/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid); 02F3473H9O (Magnesium Chloride); B8WCK70T7I (Trehalose); EC 3.2.1.- (hen egg lysozyme); EC 3.2.1.17 (Muramidase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1007/s10930-017-9705-2


  8 / 2704 MEDLINE  
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[PMID]:28257628
[Au] Autor:Sharaf A; Mercati F; Elmaghraby I; Elbaz RM; Marei EM
[Ad] Endereço:Genetic Department, Faculty of Agriculture, Ain Shams University, Cairo, 11241, Egypt. sharaf@paru.cas.cz.
[Ti] Título:Functional and comparative genome analysis of novel virulent actinophages belonging to Streptomyces flavovirens.
[So] Source:BMC Microbiol;17(1):51, 2017 Mar 03.
[Is] ISSN:1471-2180
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Next Generation Sequencing (NGS) technologies provide exciting possibilities for whole genome sequencing of a plethora of organisms including bacterial strains and phages, with many possible applications in research and diagnostics. No Streptomyces flavovirens phages have been sequenced to date; there is therefore a lack in available information about S. flavovirens phage genomics. We report biological and physiochemical features and use NGS to provide the complete annotated genomes for two new strains (Sf1 and Sf3) of the virulent phage Streptomyces flavovirens, isolated from Egyptian soil samples. RESULTS: The S. flavovirens phages (Sf1 and Sf3) examined in this study show higher adsorption rates (82 and 85%, respectively) than other actinophages, indicating a strong specificity to their host, and latent periods (15 and 30 min.), followed by rise periods of 45 and 30 min. As expected for actinophages, their burst sizes were 1.95 and 2.49 virions per mL. Both phages were stable and, as reported in previous experiments, showed a significant increase in their activity after sodium chloride (NaCl) and magnesium chloride (MgCl .6H O) treatments, whereas after zinc chloride (ZnCl2) application both phages showed a significant decrease in infection. The sequenced phage genomes are parts of a singleton cluster with sizes of 43,150 bp and 60,934 bp, respectively. Bioinformatics analyses and functional characterizations enabled the assignment of possible functions to 19 and 28 putative identified ORFs, which included phage structural proteins, lysis components and metabolic proteins. Thirty phams were identified in both phages, 10 (33.3%) of them with known function, which can be used in cluster prediction. Comparative genomic analysis revealed significant homology between the two phages, showing the highest hits among Sf1, Sf3 and the closest Streptomyces phage (VWB phages) in a specific 13Kb region. However, the phylogenetic analysis using the Major Capsid Protein (MCP) sequences highlighted that the isolated phages belong to the BG Streptomyces phage group but are clearly separated, representing a novel sub-cluster. CONCLUSION: The results of this study provide the first physiological and genomic information for S. flavovirens phages and will be useful for pharmaceutical industries based on S. flavovirens and future phage evolution studies.
[Mh] Termos MeSH primário: Bacteriófagos/genética
Bacteriófagos/patogenicidade
Genoma Viral/genética
Genoma Viral/fisiologia
Streptomyces/virologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Bacteriófagos/isolamento & purificação
Bacteriófagos/fisiologia
Sequência de Bases
Evolução Biológica
Proteínas do Capsídeo/genética
Cloretos/farmacologia
DNA Viral/isolamento & purificação
Egito
Genes Virais
Genômica
Sequenciamento de Nucleotídeos em Larga Escala/métodos
Especificidade de Hospedeiro
Cloreto de Magnésio/farmacologia
Fases de Leitura Aberta/genética
Filogenia
Análise de Sequência de DNA
Homologia de Sequência do Ácido Nucleico
Cloreto de Sódio/farmacologia
Solo
Microbiologia do Solo
Proteínas Virais/genética
Vírion
Compostos de Zinco/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsid Proteins); 0 (Chlorides); 0 (DNA, Viral); 0 (Soil); 0 (Viral Proteins); 0 (Zinc Compounds); 02F3473H9O (Magnesium Chloride); 451W47IQ8X (Sodium Chloride); 86Q357L16B (zinc chloride)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE
[do] DOI:10.1186/s12866-017-0940-7


  9 / 2704 MEDLINE  
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[PMID]:28234287
[Au] Autor:Zhi LL; Zaini MA
[Ad] Endereço:Centre of Lipids Engineering & Applied Research (CLEAR), Ibnu Sina Institute for Scientific & Industrial Research (ISI-SIR), Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia, and Malaysia Faculty of Chemical & Energy Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia E-mail: abbas@cheme.utm.my.
[Ti] Título:Adsorption properties of cationic rhodamine B dye onto metals chloride-activated castor bean residue carbons.
[So] Source:Water Sci Technol;75(3-4):864-880, 2017 02.
[Is] ISSN:0273-1223
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This work was aimed to evaluate the feasibility of castor bean residue based activated carbons prepared through metals chloride activation. The activated carbons were characterized for textural properties and surface chemistry, and the adsorption data of rhodamine B were established to investigate the removal performance. Zinc chloride-activated carbon with specific surface area of 395 m /g displayed a higher adsorption capacity of 175 mg/g. Magnesium chloride and iron(III) chloride are less toxic and promising agents for composite chemical activation. The adsorption data obeyed Langmuir isotherm and pseudo-second-order kinetics model. The rate-limiting step in the adsorption of rhodamine B is film diffusion. The positive values of enthalpy and entropy indicate that the adsorption is endothermic and spontaneous at high temperature.
[Mh] Termos MeSH primário: Semente de Rícino/química
Carvão Vegetal/química
Cloretos/química
Rodaminas/análise
Poluentes Químicos da Água/análise
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Adsorção
Cátions
Difusão
Compostos Férricos/química
Cinética
Cloreto de Magnésio/química
Rodaminas/química
Sementes/química
Propriedades de Superfície
Temperatura Ambiente
Termodinâmica
Poluentes Químicos da Água/química
Compostos de Zinco/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cations); 0 (Chlorides); 0 (Ferric Compounds); 0 (Rhodamines); 0 (Water Pollutants, Chemical); 0 (Zinc Compounds); 02F3473H9O (Magnesium Chloride); 16291-96-6 (Charcoal); 86Q357L16B (zinc chloride); K7G5SCF8IL (rhodamine B); U38V3ZVV3V (ferric chloride)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE
[do] DOI:10.2166/wst.2016.568


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[PMID]:28164896
[Au] Autor:Barde NG; Mishra DB; Ingole SO
[Ad] Endereço:Department of Skin and VD, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India.
[Ti] Título:Oral magnesium chloride: A novel approach in the management of Hailey-Hailey disease.
[So] Source:Indian J Dermatol Venereol Leprol;83(2):259-262, 2017 Mar-Apr.
[Is] ISSN:0973-3922
[Cp] País de publicação:India
[La] Idioma:eng
[Mh] Termos MeSH primário: Gerenciamento Clínico
Cloreto de Magnésio/administração & dosagem
Pênfigo Familiar Benigno/diagnóstico
Pênfigo Familiar Benigno/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Feminino
Seres Humanos
Masculino
Pênfigo Familiar Benigno/genética
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
02F3473H9O (Magnesium Chloride)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170207
[St] Status:MEDLINE
[do] DOI:10.4103/0378-6323.198459



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