Base de dados : MEDLINE
Pesquisa : D01.210.450.150.525 [Categoria DeCS]
Referências encontradas : 2462 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 247 ir para página                         

  1 / 2462 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29037848
[Au] Autor:Guchhait R; Chatterjee A; Gupta S; Debnath M; Mukherjee D; Pramanick K
[Ad] Endereço:Integrative Biology Research Unit, Department of Life Sciences, Presidency University, 86/1, College Street, Kolkata 700073, India.
[Ti] Título:Molecular mechanism of mercury-induced reproductive impairments in banded gourami, Trichogaster fasciata.
[So] Source:Gen Comp Endocrinol;255:40-48, 2018 Jan 01.
[Is] ISSN:1095-6840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mercury is one of the key pollutants responsible for the degradation of natural aquatic ecosystems. Among the different forms of mercury that exist in the environment, mercuric chloride (HgCl ) is the dominant pollutant for freshwater environments as it is used as an ingredient in antiseptics, disinfectants and preservatives, insecticides, batteries and in metallurgical and photographic operations. Pollutant may exert their action on organisms or populations by affecting their normal endocrine function as well as reproduction. Thus, the present study tried to understand the effect of mercuric chloride (HgCl ) on reproductive function and to decipher the molecular mechanism of Hg-induced reproductive impairments of female Trichogaster fasciata. Both in vivo and in vitro experiments were performed by using ecologically relevant doses of HgCl and the resulting effects on follicular development, steroidogenic potentiality, aromatase activity, aromatase gene expression and steroidogenic factor-1 (SF-1) expression pattern were analysed. In vivo exposure to HgCl caused reproductive impairments as shown by the inhibitory role of HgCl on follicular development, steroid biosynthesis and SF-1 activity. In vitro experiments revealed that aromatase activity, steroidogenesis, aromatase and SF-1 expression were blocked by HgCl . The results obtained from this study contribute to understand the molecular mechanism of HgCl -induced reproductive impairment of T. fasciata.
[Mh] Termos MeSH primário: Peixes/fisiologia
Mercúrio/toxicidade
Reprodução/fisiologia
[Mh] Termos MeSH secundário: Animais
Aromatase/genética
Aromatase/metabolismo
Estradiol/biossíntese
Feminino
Regulação Enzimológica da Expressão Gênica/efeitos dos fármacos
Cloreto de Mercúrio/toxicidade
Folículo Ovariano/efeitos dos fármacos
Folículo Ovariano/enzimologia
Folículo Ovariano/crescimento & desenvolvimento
Reprodução/efeitos dos fármacos
Fator Esteroidogênico 1/metabolismo
Esteroides/biossíntese
Testosterona/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Steroidogenic Factor 1); 0 (Steroids); 3XMK78S47O (Testosterone); 4TI98Z838E (Estradiol); 53GH7MZT1R (Mercuric Chloride); EC 1.14.14.1 (Aromatase); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171018
[St] Status:MEDLINE


  2 / 2462 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28926624
[Au] Autor:Meng XN; Chen QM; Fan HY; Song TF; Cui N; Zhao JY; Jia SM; Meng KX
[Ad] Endereço:College of Horticulture, Shenyang Agricultural University, Shenyang, People's Republic of China.
[Ti] Título:Molecular characterization, expression analysis and heterologous expression of two translationally controlled tumor protein genes from Cucumis sativus.
[So] Source:PLoS One;12(9):e0184872, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The translationally controlled tumor protein (TCTP) is a family of abundant and ubiquitous proteins involved in several important primary functions. Cucumbers harbor two TCTP genes, CsTCTP1 and CsTCTP2; however, their functional roles remain unclear. In this study, we isolated CsTCTP1 and CsTCTP2 (XP-004134215 and XP-004135602, respectively) promoters, full-length cDNA and genomic sequences from Cucumis sativus. Bioinformatics analysis, containing cis-acting elements, structural domains, phylogenetic tree and conserved motifs, suggested the conservation and divergence of CsTCTP1 and CsTCTP2, thus providing knowledge regarding their functions. Expression analysis indicated that CsTCTP1 and CsTCTP2 exhibited tissue-specific expression and were regulated by biotic or abiotic stresses in C. sativus. Furthermore, CsTCTP1 and CsTCTP2 were regulated by ABA and may be associated with the TOR (target of rapamycin) signaling pathway. In a prokaryotic expression analysis, CsTCTP1 and CsTCTP2 showed positive responses to salt and heat stresses and a negative response to drought and HgCl2 stresses. TCTP may exert multiple functions in various cellular processes.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/metabolismo
Cucumis sativus/metabolismo
Regulação da Expressão Gênica de Plantas
Proteínas de Plantas/metabolismo
[Mh] Termos MeSH secundário: Ácido Abscísico/farmacologia
Sequência de Aminoácidos
Biomarcadores Tumorais/classificação
Biomarcadores Tumorais/genética
DNA de Plantas/química
DNA de Plantas/isolamento & purificação
DNA de Plantas/metabolismo
Secas
Cloreto de Mercúrio/toxicidade
Filogenia
Proteínas de Plantas/classificação
Proteínas de Plantas/genética
Regiões Promotoras Genéticas
Alinhamento de Sequência
Análise de Sequência de DNA
Transdução de Sinais/efeitos dos fármacos
Cloreto de Sódio/farmacologia
Estresse Fisiológico
Serina-Treonina Quinases TOR/metabolismo
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (DNA, Plant); 0 (Plant Proteins); 0 (tumor protein, translationally-controlled 1); 451W47IQ8X (Sodium Chloride); 53GH7MZT1R (Mercuric Chloride); 72S9A8J5GW (Abscisic Acid); EC 2.7.1.1 (TOR Serine-Threonine Kinases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184872


  3 / 2462 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28889024
[Au] Autor:Bjørklund G; Dadar M; Mutter J; Aaseth J
[Ad] Endereço:Council for Nutritional and Environmental Medicine, Toften 24, 8610 Mo i Rana, Norway. Electronic address: bjorklund@conem.org.
[Ti] Título:The toxicology of mercury: Current research and emerging trends.
[So] Source:Environ Res;159:545-554, 2017 11.
[Is] ISSN:1096-0953
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Mercury (Hg) is a persistent bio-accumulative toxic metal with unique physicochemical properties of public health concern since their natural and anthropogenic diffusions still induce high risk to human and environmental health. The goal of this review was to analyze scientific literature evaluating the role of global concerns over Hg exposure due to human exposure to ingestion of contaminated seafood (methyl-Hg) as well as elemental Hg levels of dental amalgam fillings (metallic Hg), vaccines (ethyl-Hg) and contaminated water and air (Hg chloride). Mercury has been recognized as a neurotoxicant as well as immunotoxic and designated by the World Health Organization as one of the ten most dangerous chemicals to public health. It has been shown that the half-life of inorganic Hg in human brains is several years to several decades. Mercury occurs in the environment under different chemical forms as elemental Hg (metallic), inorganic and organic Hg. Despite the raising understanding of the Hg toxicokinetics, there is still fully justified to further explore the emerging theories about its bioavailability and adverse effects in humans. In this review, we describe current research and emerging trends in Hg toxicity with the purpose of providing up-to-date information for a better understanding of the kinetics of this metal, presenting comprehensive knowledge on published data analyzing its metabolism, interaction with other metals, distribution, internal doses and targets, and reservoir organs.
[Mh] Termos MeSH primário: Exposição Ambiental
Compostos de Etilmercúrio/toxicidade
Cloreto de Mercúrio/toxicidade
Mercúrio/toxicidade
Compostos de Metilmercúrio/toxicidade
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Ethylmercury Compounds); 0 (Methylmercury Compounds); 53GH7MZT1R (Mercuric Chloride); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170911
[St] Status:MEDLINE


  4 / 2462 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28841366
[Au] Autor:Tollefsen KE; Song Y; Høgåsen T; Øverjordet IB; Altin D; Hansen BH
[Ad] Endereço:a Norwegian Institute for Water Research (NIVA) , Oslo , Norway.
[Ti] Título:Mortality and transcriptional effects of inorganic mercury in the marine copepod Calanus finmarchicus.
[So] Source:J Toxicol Environ Health A;80(16-18):845-861, 2017.
[Is] ISSN:1528-7394
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Inorganic mercury (Hg) is highly toxic to organisms including crustaceans and displays multiple toxic modes of action (MoA). The main aim of this investigation was to assess the acute and sublethal toxicity mediated by mercury chloride (HgCl ) in the marine copepod Calanus finmarchicus. A combination of short-term static studies to determine acute toxicity and a transcriptional investigation to characterize the sublethal MoA of HgCl were conducted with an in-house continuous culture of C. finmarchicus. Transcriptional changes were determined by a custom 6.6 k C. finmarchicus Agilent oligonucleotide microarray and quantitative RT-PCR analysis. Data demonstrate that HgCl produced a concentration- and time-dependent reduction in survival (NOEC = 6.9 µg/L [Hg ] and LC of 279, 73, 48, and 34 µg/L [Hg ] after 24, 48, 72, and 96 h, respectively) and that exposure to sublethal concentrations of HgCl (5 µg/L [Hg2 ]) induced differential expression of 98 features (probes) on the microarray. Gene ontology (GO) and toxicological pathway analyses suggested that the main MOA were (1) uncoupling of mitochondrial oxidative phosphorylation (OXPHOS) and ATP production, (2) oxidative stress and macromolecular damage, (3) inactivation of cellular enzymes, (4) induction of cellular apoptosis and autophagocytosis, (5) over-excitation of glutamate receptors (neurotoxicity), (6) disruption of calcium homeostasis and signaling, and (7) modulation of nuclear receptor activity involved in vitamin D receptor signaling. Quantitative RT-PCR analysis verified that oligoarray performed reliably in terms of specificity and response, thus demonstrating that Hg exerts multiple potential MoA in C. finmarchicus.
[Mh] Termos MeSH primário: Copépodes/efeitos dos fármacos
Cloreto de Mercúrio/toxicidade
Mercúrio/toxicidade
[Mh] Termos MeSH secundário: Animais
Biologia Computacional
Copépodes/metabolismo
Ontologia Genética
Análise em Microsséries
Estresse Oxidativo/efeitos dos fármacos
Fosforilação
Espécies Reativas de Oxigênio/metabolismo
Receptores Citoplasmáticos e Nucleares/genética
Receptores Citoplasmáticos e Nucleares/metabolismo
Transdução de Sinais
Transmissão Sináptica/efeitos dos fármacos
Testes de Toxicidade Aguda
Poluentes Químicos da Água/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reactive Oxygen Species); 0 (Receptors, Cytoplasmic and Nuclear); 0 (Water Pollutants, Chemical); 53GH7MZT1R (Mercuric Chloride); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE
[do] DOI:10.1080/15287394.2017.1352198


  5 / 2462 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28641222
[Au] Autor:Tang H; Duan Y; Zhu C; Cai T; Li C; Cai L
[Ad] Endereço:Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education, School of Energy and Environment, Southeast University, Nanjing, Jiangsu 210096, China.
[Ti] Título:Theoretical evaluation on selective adsorption characteristics of alkali metal-based sorbents for gaseous oxidized mercury.
[So] Source:Chemosphere;184:711-719, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Alkali metal-based sorbents are potential for oxidized mercury (Hg ) selective adsorption but show hardly effect to elemental mercury (Hg ) in flue gas. Density functional theory (DFT) was employed to investigate the Hg and HgCl adsorption mechanism over alkali metal-based sorbents, including calcium oxide (CaO), magnesium oxide (MgO), potassium chloride (KCl) and sodium chloride (NaCl). Hg was found to weakly interact with CaO (001), MgO (001), KCl (001) and NaCl (001) surfaces while HgCl was effectively adsorbed on top-O and top-Cl sites. Charge transfer and bond population were calculated to discuss the covalency and ionicity of HgCl bonding with the adsorption sites. The partial density of states (PDOS) analysis manifests that HgCl strongly interacts with surface sites through the orbital hybridizations between Hg and top O or Cl. Frontier molecular orbital (FMO) energy and Mulliken electronegativity are introduced as the quantitative criteria to evaluate the reactivity of mercury species and alkali metal-based sorbents. HgCl is identified as a Lewis acid and more reactive than Hg . The Lewis basicity of the four alkali metal-based sorbents is predicted as the increasing order: NaCl < MgO < KCl < CaO, in consistence with the trend of HgCl adsorption energies.
[Mh] Termos MeSH primário: Mercúrio/química
Metais Alcalinos/química
Modelos Químicos
[Mh] Termos MeSH secundário: Adsorção
Compostos de Cálcio
Gases
Óxido de Magnésio
Cloreto de Mercúrio
Compostos de Mercúrio
Óxidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium Compounds); 0 (Gases); 0 (Mercury Compounds); 0 (Metals, Alkali); 0 (Oxides); 3A3U0GI71G (Magnesium Oxide); 53GH7MZT1R (Mercuric Chloride); C7X2M0VVNH (lime); FXS1BY2PGL (Mercury); IY191986AO (mercuric oxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE


  6 / 2462 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28536007
[Au] Autor:Zhang BB; Li WK; Hou WY; Luo Y; Shi JZ; Li C; Wei LX; Liu J
[Ad] Endereço:Key Lab for Pharmacology of Ministry of Education, Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563000, China.
[Ti] Título:Zuotai and HgS differ from HgCl and methyl mercury in Hg accumulation and toxicity in weanling and aged rats.
[So] Source:Toxicol Appl Pharmacol;331:76-84, 2017 Sep 15.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mercury sulfides are used in Ayurvedic medicines, Tibetan medicines, and Chinese medicines for thousands of years and are still used today. Cinnabar (α-HgS) and metacinnabar (ß-HgS) are different from mercury chloride (HgCl ) and methylmercury (MeHg) in their disposition and toxicity. Whether such scenario applies to weanling and aged animals is not known. To address this question, weanling (21d) and aged (450d) rats were orally given Zuotai (54% ß-HgS, 30mg/kg), HgS (α-HgS, 30mg/kg), HgCl (34.6mg/kg), or MeHg (MeHgCl, 3.2mg/kg) for 7days. Accumulation of Hg in kidney and liver, and the toxicity-sensitive gene expressions were examined. Animal body weight gain was decreased by HgCl and to a lesser extent by MeHg, but unaltered after Zuotai and HgS. HgCl and MeHg produced dramatic tissue Hg accumulation, increased kidney (kim-1 and Ngal) and liver (Ho-1) injury-sensitive gene expressions, but such changes are absent or mild after Zuotai and HgS. Aged rats were more susceptible than weanling rats to Hg toxicity. To examine roles of transporters in Hg accumulation, transporter gene expressions were examined. The expression of renal uptake transporters Oat1, Oct2, and Oatp4c1 and hepatic Oatp2 was decreased, while the expression of renal efflux transporter Mrp2, Mrp4 and Mdr1b was increased following HgCl and MeHg, but unaffected by Zuotai and HgS. Thus, Zuotai and HgS differ from HgCl and MeHg in producing tissue Hg accumulation and toxicity, and aged rats are more susceptible than weanling rats. Transporter expression could be adaptive means to reduce tissue Hg burden.
[Mh] Termos MeSH primário: Envelhecimento/efeitos dos fármacos
Medicamentos de Ervas Chinesas/toxicidade
Cloreto de Mercúrio/toxicidade
Compostos de Mercúrio/toxicidade
Compostos de Metilmercúrio/toxicidade
[Mh] Termos MeSH secundário: Administração Oral
Envelhecimento/metabolismo
Animais
Animais Recém-Nascidos
Medicamentos de Ervas Chinesas/administração & dosagem
Medicamentos de Ervas Chinesas/metabolismo
Cloreto de Mercúrio/administração & dosagem
Cloreto de Mercúrio/metabolismo
Mercúrio/administração & dosagem
Mercúrio/metabolismo
Mercúrio/toxicidade
Compostos de Mercúrio/administração & dosagem
Compostos de Mercúrio/metabolismo
Compostos de Metilmercúrio/administração & dosagem
Compostos de Metilmercúrio/metabolismo
Ratos
Ratos Sprague-Dawley
Desmame
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Mercury Compounds); 0 (Methylmercury Compounds); 0 (zuotai); 53GH7MZT1R (Mercuric Chloride); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE


  7 / 2462 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28411467
[Au] Autor:Wang M; Jeong CB; Li Y; Lee JS
[Ad] Endereço:Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems/College of the Environment & Ecology, Xiamen University, Xiamen 361102, China.
[Ti] Título:Different transcriptomic responses of two marine copepods, Tigriopus japonicus and Pseudodiaptomus annandalei, to a low dose of mercury chloride (HgCl ).
[So] Source:Aquat Toxicol;187:124-131, 2017 Jun.
[Is] ISSN:1879-1514
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Mercury (Hg) pollution is a ubiquitous and serious concern in marine environments, but the response mechanisms of marine animals to Hg pollution (i.e., toxicity/tolerance) are poorly understood. To compare the global responses of two marine copepods (Tigriopus japonicus and Pseudodiaptomus annandalei), we analyzed whole transcriptomes using RNA-seq technology in response to Hg treatment (a nominal 10µg/L HgCl in seawater) for 5h. Hg was strikingly accumulated in both copepods under treatment. The Hg concentration in P. annandalei was higher under metal exposure by approximately 1.4-fold compared with treated T. japonicus. Among transcriptomic data, 101 genes in T. japonicus and 18 genes in P. annandalei were differentially regulated in response to Hg exposure. The up-regulated genes in T. japonicus were concerned with stress, growth, and development, while the down-regulated ones were mainly related to immune response. In P. annandalei, most of the differentially expressed genes were up-regulated, and all were involved in stress response. Our work indicated that Hg exhibits endocrine-disrupting potential at the transcriptomic level in marine copepods. Overall, our study demonstrates the species-specific molecular responses of these two copepods to Hg pollution.
[Mh] Termos MeSH primário: Copépodes/efeitos dos fármacos
Disruptores Endócrinos/toxicidade
Cloreto de Mercúrio/toxicidade
Transcriptoma/efeitos dos fármacos
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Copépodes/genética
Copépodes/metabolismo
Relação Dose-Resposta a Droga
Disruptores Endócrinos/análise
Disruptores Endócrinos/metabolismo
Cloreto de Mercúrio/análise
Cloreto de Mercúrio/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/genética
Água do Mar/química
Especificidade da Espécie
Regulação para Cima
Poluentes Químicos da Água/análise
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Endocrine Disruptors); 0 (Water Pollutants, Chemical); 53GH7MZT1R (Mercuric Chloride)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170416
[St] Status:MEDLINE


  8 / 2462 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28406445
[Au] Autor:Macirella R; Brunelli E
[Ad] Endereço:Department of Biology, Ecology and Earth Science, University of Calabria, Via P. Bucci 4/B, 87036 Rende (Cosenza), Italy. rachele.macirella@unical.it.
[Ti] Título:Morphofunctional Alterations in Zebrafish (Danio rerio) Gills after Exposure to Mercury Chloride.
[So] Source:Int J Mol Sci;18(4), 2017 Apr 13.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Mercury (Hg) is a global pollutant that may exert its toxic effects on living organisms and is found in both aquatic and terrestrial ecosystems in three chemical forms; elemental, organic, and inorganic. The inorganic form (iHg) tends to predominantly accumulate in aquatic environments. The gill apparatus is a very dynamic organ that plays a fundamental role in gas exchange, osmoregulation, acid-base regulation, detoxification, and excretion, and the gills are the primary route of waterborne iHg entrance in fish. In the present work we investigated the morphofunctional and ultrastructural effects in gills after 96 h exposure to two low HgCl2 concentrations (7.7 and 38.5 µg/L). Our results clearly demonstrated that a short-term exposure to low concentrations of mercury chloride resulted in gill morphology alterations and in the modifications of both Na K⁺-ATPase and metallothioneins (MTs) expression pattern. The main morphological effects recorded in this work were represented by hyperplasia and ectopia of chloride cells (CCs), lamellar fusion, increased mucous secretion, alteration of pavement cells (PVCs), detachment of the secondary epithelium, pillar cell degeneration, degeneration, and apoptosis. Trough immunohistochemistry and real-time PCR analysis also showed a dose-related modulation of Na⁺/K⁺-ATPase and MTs.
[Mh] Termos MeSH primário: Brânquias/efeitos dos fármacos
Cloreto de Mercúrio/toxicidade
Poluentes Químicos da Água/toxicidade
Peixe-Zebra/metabolismo
[Mh] Termos MeSH secundário: Animais
Brânquias/metabolismo
Brânquias/ultraestrutura
Imuno-Histoquímica
Metalotioneína/genética
Metalotioneína/metabolismo
Microscopia Eletrônica de Varredura
Reação em Cadeia da Polimerase em Tempo Real
ATPase Trocadora de Sódio-Potássio/genética
ATPase Trocadora de Sódio-Potássio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); 53GH7MZT1R (Mercuric Chloride); 9038-94-2 (Metallothionein); EC 3.6.3.9 (Sodium-Potassium-Exchanging ATPase)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170507
[Lr] Data última revisão:
170507
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE


  9 / 2462 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27939723
[Au] Autor:Lu X; Xiang Y; Yang G; Zhang L; Wang H; Zhong S
[Ad] Endereço:Key Laboratory of Freshwater Biodiversity Conservation and Utilization of Ministry of Agriculture, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, Hubei, China. Electronic address: luxing@yfi.ac.cn.
[Ti] Título:Transcriptomic characterization of zebrafish larvae in response to mercury exposure.
[So] Source:Comp Biochem Physiol C Toxicol Pharmacol;192:40-49, 2017 Feb.
[Is] ISSN:1532-0456
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mercury is a widespread toxicant in aquatic environment that can cause deleterious effects on fish. Although a number of mercury-regulated genes have been investigated in adult fish, the transcriptional responses of fish larvae to acute mercury exposure are not well understood. In this study, RNA sequencing was used to examine the transcriptional changes in developing zebrafish larvae under a low concentration of mercuric chloride exposure from 24 to 120hpf. Our initial results showed that a total of 142.59 million raw reads were obtained from sequencing libraries and about 86% of the processed reads were mapped to the reference genome of zebrafish. Differential expression analysis identified 391 up- and 87 down-regulated genes. Gene ontology enrichment analysis revealed that most of the differential expressed genes are closely related to the regulation of cellular process, metabolic process, multicellular organismal process, biological regulation, pigmentation, and response to stimulus. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis demonstrated that antigen processing and presentation was the most significantly enriched pathway. Moreover, we characterized a novel and sensitive mercury-induced ABCB (ATP- binding cassette B subfamily) transporter gene - abcb5. This gene is localized on zebrafish chromosome 16 and contains a 4014bp open-reading frame. The deduced polypeptide is composed of 1337 amino acids and possesses most of functional domains and critical residues defined in human and mouse ABCB5/Abcb5. Functional analysis in vitro demonstrated that overexpression of zebrafish abcb5 gene can significantly decrease the cytotoxicity of mercury in LLC-PK1 cells, implying it is a potential efflux transporter of mercury. Thus, these findings provide useful insights to help further understand the transcriptional response and detoxification ability of zebrafish larvae following acute exposure to mercury.
[Mh] Termos MeSH primário: Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos
Larva/efeitos dos fármacos
Cloreto de Mercúrio/toxicidade
Transcrição Genética/efeitos dos fármacos
Poluentes Químicos da Água/toxicidade
Proteínas de Peixe-Zebra/genética
Peixe-Zebra/genética
[Mh] Termos MeSH secundário: Membro 1 da Subfamília B de Cassetes de Ligação de ATP/genética
Membro 1 da Subfamília B de Cassetes de Ligação de ATP/metabolismo
Animais
Transporte Biológico
Biologia Computacional
Bases de Dados Genéticas
Perfilação da Expressão Gênica/métodos
Redes Reguladoras de Genes
Sequenciamento de Nucleotídeos em Larga Escala
Células LLC-PK1
Larva/genética
Cloreto de Mercúrio/metabolismo
Suínos
Fatores de Tempo
Transfecção
Poluentes Químicos da Água/metabolismo
Peixe-Zebra/metabolismo
Proteínas de Peixe-Zebra/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ATP-Binding Cassette, Sub-Family B, Member 1); 0 (Water Pollutants, Chemical); 0 (Zebrafish Proteins); 53GH7MZT1R (Mercuric Chloride)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


  10 / 2462 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27919736
[Au] Autor:Venkatesan RS; Sadiq AM
[Ad] Endereço:P.G and Research Department of Biochemistry, Adhiparasakthi College of Arts and Science, (Autonomous) G.B.Nagar, Kalavai, Vellore District, Tamilnadu 632506, India. Electronic address: mercury.morin@gmail.com.
[Ti] Título:Effect of morin-5'-sulfonic acid sodium salt on the expression of apoptosis related proteins caspase 3, Bax and Bcl 2 due to the mercury induced oxidative stress in albino rats.
[So] Source:Biomed Pharmacother;85:202-208, 2017 Jan.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Many environmental contaminants have been reported to disturb the pro-oxidant or antioxidant balance of the cells by inducing oxidative stress. Oxidative stress mediated by the HgCl induces DNA, protein and lipid oxidation resulted in necrosis or apoptosis, or both. Currently flavonoids are being emerging topic and reported to have antiviral, anti-inflammatory, anti- tumor and antioxidant activities. Morin is one of the flavonoid protects the cells from oxygen free radical damage and scavenges the free radicals and metals and also heals the injured cells commercially. Morin hydrate is sparingly soluble in water. Hence, the water soluble morin -5'- sulfonic acid sodium salt (NaMSA) was selected and synthesized. Aim of the present study was to analyze the effect of morin-5'-sulfonic acid sodium salt on the expression of apoptosis related proteins caspase 3, Bax and Bcl 2 due to the mercury induced oxidative stress in albino rats.. The experimental rats were exposed to sub lethal concentration of mercuric chloride (1.25mg/kg) and the ameliorating effect of NaMSA was studied by using apoptotic protein markers Bax and caspase-3 and Bcl-2. The obtained results were analyzed using one way analysis of variance by the Duncan's Multiple comparison test to determine the level of significance (p) and p<0.05 was considered as statistically significant. Administration of mercuric chloride (1.25mg/kg) in the experimental rats increased the expression of Bax and caspase-3 and a decreased expression was noted in the Bcl-2 level compared with control bands significantly (p<0.05). On the other hand NaMSA (50mg/kg) and HgCl (1.25mg/kg) simultaneous administration did not bring any change in the protein expression of Bax, Caspase-3 and Bcl-2 levels compared with control rats. Hence, the membrane damage was protected, stopped the cell death and apoptosis. This could be due to the morin-5'-sulfonic acid sodium salt effective chelation action on the HgCl generated free radicals.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Apoptose/efeitos dos fármacos
Caspase 3/metabolismo
Flavonoides/farmacologia
Intoxicação por Mercúrio/prevenção & controle
Estresse Oxidativo/efeitos dos fármacos
Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
Ácidos Sulfônicos/farmacologia
Proteína X Associada a bcl-2/metabolismo
[Mh] Termos MeSH secundário: Animais
Citoproteção
Modelos Animais de Doenças
Rim/efeitos dos fármacos
Rim/metabolismo
Rim/patologia
Fígado/efeitos dos fármacos
Fígado/metabolismo
Fígado/patologia
Masculino
Cloreto de Mercúrio
Intoxicação por Mercúrio/metabolismo
Intoxicação por Mercúrio/patologia
Miocárdio/metabolismo
Miocárdio/patologia
Ratos Wistar
Transdução de Sinais/efeitos dos fármacos
Testículo/efeitos dos fármacos
Testículo/metabolismo
Testículo/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Bax protein, rat); 0 (Flavonoids); 0 (Proto-Oncogene Proteins c-bcl-2); 0 (Sulfonic Acids); 0 (bcl-2-Associated X Protein); 0 (morin-5'-sulfonic acid); 53GH7MZT1R (Mercuric Chloride); EC 3.4.22.- (Casp3 protein, rat); EC 3.4.22.- (Caspase 3)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161207
[St] Status:MEDLINE



página 1 de 247 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde