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Pesquisa : D01.248.497.158 [Categoria DeCS]
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  1 / 13023 MEDLINE  
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[PMID]:29184996
[Au] Autor:Liu J; Liang Y; Shen J; Bai Q
[Ad] Endereço:Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, Modern Separation Science Key Laboratory of Shaanxi Province, College of Chemistry & Materials Science, Northwest University, Xi'an, Shaanxi, 710069, China. jwliu@nwu.edu.cn.
[Ti] Título:Polymeric ionic liquid-assembled graphene-immobilized silica composite for selective isolation of human serum albumin from human whole blood.
[So] Source:Anal Bioanal Chem;410(2):573-584, 2018 Jan.
[Is] ISSN:1618-2650
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Polymeric ionic liquids (PILs) with 1-vinyl-3-ethylimidazolium cations and two different anions of Br and PF were assembled onto the surface of graphene (G) nanosheets. The derived two composites, i.e., PIL(Br)-G and PIL(PF )-G, were further efficiently immobilized onto the surface of silica nanoparticles via self-assembly technique. The obtained two PIL-G/SiO nanocomposites exhibited diverse adsorption performances toward proteins through adjusting the anions of PILs. Electrostatic attractions between proteins and the nanocomposites dominated protein adsorption, while the presence of PF anions weakened electrostatic interactions and deteriorated the selective adsorption of target protein, i.e., bovine serum albumin (BSA) in this case. Specifically, PIL(Br)-G/SiO nanocomposite displayed high selectivity toward BSA and a high adsorption efficiency of ca. 98% was achieved for 100 mg L BSA in a Britton-Robinson (B-R) buffer at pH 5. HPLC analysis demonstrated the selectivity of PIL(Br)-G/SiO nanocomposite toward BSA in the presence of abundant hemoglobin and cytochrome c. The practical applicability was verified by performing selective isolation of human serum albumin (HSA) from human whole blood. Graphical abstract Selective isolation of human serum albumin from blood by polymeric ionic liquid assembled graphene immobilized silica nanocomposite with tunable anions.
[Mh] Termos MeSH primário: Grafite/química
Líquidos Iônicos/química
Polímeros/química
Albumina Sérica Humana/isolamento & purificação
Dióxido de Silício/química
[Mh] Termos MeSH secundário: Adsorção
Ânions/química
Seres Humanos
Concentração de Íons de Hidrogênio
Nanocompostos/química
Eletricidade Estática
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anions); 0 (Ionic Liquids); 0 (Polymers); 7631-86-9 (Silicon Dioxide); 7782-42-5 (Graphite); ZIF514RVZR (Serum Albumin, Human)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1007/s00216-017-0758-z


  2 / 13023 MEDLINE  
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[PMID]:28987407
[Au] Autor:Shao HY; Wu MH; Deng F; Xu G; Liu N; Li X; Tang L
[Ad] Endereço:School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, PR China; Shanghai Environmental Monitoring Center, Shanghai, 200235, PR China.
[Ti] Título:Electron beam irradiation induced degradation of antidepressant drug fluoxetine in water matrices.
[So] Source:Chemosphere;190:184-190, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:With the development of psychiatric disorder in the current society, abuse of antidepressant drug fluoxetine (FLX) has made such compound an emerging contaminant in natural waters, and causes endocrine systems disturbance on some aquatic species. Herein, an efficient advanced oxidation process (AOP), electron beam irradiation was carried out to investigate the decomposition characteristics of such novel environmental pollutant, including the effects of initial concentration, pH, radical scavengers and anions. The results showed that FLX degradation followed pseudo-first-order kinetics. The degradation rate and dose constant decreased with increasing initial FLX concentration; and G-values elevated with the increase of initial concentration but reduced with increase of absorbed dose. Acidic condition was more conducive to FLX destruction than neutral and alkaline. The radical scavenger experiments indicated OH was the main reactive species for the decomposition of FLX, while the reductive species e and H played an adjuvant role. The presence of anions slightly decreased or even no impact on FLX degradation rate. Various water matrices influenced degradation processes of FLX. Experimental results suggested radiolytic degradation showed the best performance in pure water rather than natural water no matter with filtration or not. Moreover, with the occurrence of defluorination and dealkylation during degradation process, some organic and inorganic intermediates were detected, and the possible degradation mechanisms and pathways of FLX were proposed.
[Mh] Termos MeSH primário: Fluoxetina/efeitos da radiação
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Ânions/farmacologia
Antidepressivos/efeitos da radiação
Elétrons
Fluoxetina/química
Cinética
Oxirredução
Poluentes Químicos da Água/química
Poluentes Químicos da Água/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anions); 0 (Antidepressive Agents); 0 (Water Pollutants, Chemical); 01K63SUP8D (Fluoxetine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171009
[St] Status:MEDLINE


  3 / 13023 MEDLINE  
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[PMID]:28826031
[Au] Autor:Tran HN; Viet PV; Chao HP
[Ad] Endereço:Department of Environmental Engineering, Chung Yuan Christian University, Chungli 32023, Taiwan.
[Ti] Título:Surfactant modified zeolite as amphiphilic and dual-electronic adsorbent for removal of cationic and oxyanionic metal ions and organic compounds.
[So] Source:Ecotoxicol Environ Saf;147:55-63, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A hydrophilic Y zeolite was primarily treated with sodium hydroxide to enhance its cation exchange capacity (Na-zeolite). The organo-zeolite (Na-H-zeolite) was prepared by a modification process of the external surface of Na-zeolite with a cationic surfactant (hexadecyltrimethylammonium; HDTMA). Three adsorbents (i.e., pristine zeolite, Na-zeolite, and Na-H-zeolite) were characterized with nitrogen adsorption/desorption isotherms, scanning electron microscopy coupled with energy dispersive X-ray spectroscopy, cation exchange capacities, and zeta potential. Results demonstrated that HDTMA can be adsorbed on the surface of Na-zeolite to form patchy bilayers. The adsorption capacity of several hazardous pollutants (i.e., Pb , Cu , Ni , Cr O , propylbenzene, ethylbenzene, toluene, benzene, and phenol) onto Na-H-zeolite was investigated in a single system and multiple-components. Adsorption isotherm was measured to further understand the effects of the modification process on the adsorption behaviors of Na-H-zeolite. Adsorption performances indicated that Na-H-zeolite can simultaneously adsorb the metal cations (on the surface not covered by HDTMA), oxyanions (on the surface covered by HDTMA). Na-H-zeolite also exhibited both hydrophilic and hydrophobic surfaces to uptake organic compounds with various water solubilities (from 55 to 75,000mg/L). It was experimentally concluded that Na-H-zeolite is a potential dual-electronic and amphiphilic adsorbent for efficiently removing a wide range of potentially toxic pollutants from aquatic environments.
[Mh] Termos MeSH primário: Metais Pesados/análise
Compostos Orgânicos/análise
Tensoativos/química
Poluentes Químicos da Água/análise
Purificação da Água/métodos
Zeolitas/química
[Mh] Termos MeSH secundário: Adsorção
Ânions
Cátions
Interações Hidrofóbicas e Hidrofílicas
Metais Pesados/química
Modelos Teóricos
Compostos Orgânicos/química
Óxidos
Solubilidade
Propriedades de Superfície
Poluentes Químicos da Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anions); 0 (Cations); 0 (Metals, Heavy); 0 (Organic Chemicals); 0 (Oxides); 0 (Surface-Active Agents); 0 (Water Pollutants, Chemical); 1318-02-1 (Zeolites)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170822
[St] Status:MEDLINE


  4 / 13023 MEDLINE  
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[PMID]:28461447
[Au] Autor:Hoffmann MC; Pfänder Y; Tintel M; Masepohl B
[Ad] Endereço:Biologie der Mikroorganismen, Fakultät für Biologie und Biotechnologie, Ruhr-Universität Bochum, Bochum, Germany.
[Ti] Título:Bacterial PerO Permeases Transport Sulfate and Related Oxyanions.
[So] Source:J Bacteriol;199(14), 2017 07 15.
[Is] ISSN:1098-5530
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:synthesizes the high-affinity ABC transporters CysTWA and ModABC to specifically import the chemically related oxyanions sulfate and molybdate, respectively. In addition, has the low-affinity permease PerO acting as a general oxyanion transporter, whose elimination increases tolerance to molybdate and tungstate. Although PerO-like permeases are widespread in bacteria, their function has not been examined in any other species to date. Here, we present evidence that PerO permeases from the alphaproteobacteria , , , and and the gammaproteobacterium functionally substitute for PerO in sulfate uptake and sulfate-dependent growth, as shown by assimilation of radioactively labeled sulfate and heterologous complementation. Disruption of genes in , , and increased tolerance to tungstate and, in the case of , to molybdate, suggesting that heterometal oxyanions are common substrates of PerO permeases. This study supports the view that bacterial PerO permeases typically transport sulfate and related oxyanions and, hence, form a functionally conserved permease family. Despite the widespread distribution of PerO-like permeases in bacteria, our knowledge about PerO function until now was limited to one species, In this study, we showed that PerO proteins from diverse bacteria are functionally similar to the prototype, suggesting that PerO permeases form a conserved family whose members transport sulfate and related oxyanions.
[Mh] Termos MeSH primário: Proteínas de Bactérias/metabolismo
Proteínas de Membrana Transportadoras/metabolismo
Rhodobacter capsulatus/enzimologia
Sulfatos/metabolismo
[Mh] Termos MeSH secundário: Ânions/metabolismo
Proteínas de Bactérias/genética
Transporte Biológico/fisiologia
Regulação Bacteriana da Expressão Gênica/fisiologia
Regulação Enzimológica da Expressão Gênica/fisiologia
Proteínas de Membrana Transportadoras/genética
Mutação
Rhodobacter capsulatus/genética
Rhodobacter capsulatus/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anions); 0 (Bacterial Proteins); 0 (Membrane Transport Proteins); 0 (Sulfates)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  5 / 13023 MEDLINE  
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[PMID]:29313537
[Au] Autor:Moyer P; Smith MD; Abdoulmoumine N; Chmely SC; Smith JC; Petridis L; Labbé N
[Ad] Endereço:Center for Renewable Carbon, University of Tennessee, 2506 Jacob Drive, Knoxville, TN 37996-4542, USA. nlabbe@utk.edu.
[Ti] Título:Relationship between lignocellulosic biomass dissolution and physicochemical properties of ionic liquids composed of 3-methylimidazolium cations and carboxylate anions.
[So] Source:Phys Chem Chem Phys;20(4):2508-2516, 2018 Jan 24.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The ionic liquid (IL) 1-ethyl-3-methylimidazolium acetate ([EMIM]Acetate) has been widely used for biomass processing, i.e., to pretreat, activate, or fractionate lignocellulosic biomass to produce soluble sugars and lignin. However, this IL does not achieve high biomass solubility, therefore minimizing the efficiency of biomass processing. In this study, [EMIM]Acetate and three other ILs composed of different 3-methylimidazolium cations and carboxylate anions ([EMIM]Formate, 1-allyl-3-methylimidazolium ([AMIM]) formate, and [AMIM]Acetate) were analyzed to relate their physicochemical properties to their biomass solubility performance. While all four ILs are able to dissolve hybrid poplar under fairly mild process conditions (80 °C and 100 RPM stirring), [AMIM]Formate and [AMIM]Acetate have particularly increased biomass solubility of 40 and 32%, respectively, relative to [EMIM]Acetate. Molecular dynamics simulations suggest that strong interactions between IL and specific plant biopolymers may contribute to this enhanced solubilization, as the calculated second virial coefficients between ILs and hemicellullose are most favorable for [AMIM]Formate, matching the trend of the experimental solubility measurements. The simulations also reveal that the interactions between the ILs and hemicellulose are an important factor in determining the overall biomass solubility, whereas lignin-IL interactions were not found to vary significantly, consistent with literature. The combined experimental and simulation studies identify [AMIM]Formate as an efficient biomass solvent and explain its efficacy, suggesting a new approach to rationally select ionic liquid solvents for lignocellulosic deconstruction.
[Mh] Termos MeSH primário: Compostos Alílicos/química
Imidazóis/química
Líquidos Iônicos/química
Polissacarídeos/química
[Mh] Termos MeSH secundário: Ânions/química
Biomassa
Cátions/química
Simulação de Dinâmica Molecular
Solubilidade
Temperatura Ambiente
Termogravimetria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (1-allyl-3-methylimidazolium); 0 (Allyl Compounds); 0 (Anions); 0 (Cations); 0 (Imidazoles); 0 (Ionic Liquids); 0 (Polysaccharides); 8024-50-8 (hemicellulose); TVE1D62MAK (1-ethyl-3-methylimidazolium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1039/c7cp07195g


  6 / 13023 MEDLINE  
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[PMID]:29297909
[Au] Autor:Katayama K; Furutani Y; Iwaki M; Fukuda T; Imai H; Kandori H
[Ad] Endereço:Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya 466-8555, Japan. kandori@nitech.ac.jp.
[Ti] Título:"In situ" observation of the role of chloride ion binding to monkey green sensitive visual pigment by ATR-FTIR spectroscopy.
[So] Source:Phys Chem Chem Phys;20(5):3381-3387, 2018 Jan 31.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Long-wavelength-sensitive (LWS) pigment possesses a chloride binding site in its protein moiety. The binding of chloride alters the absorption spectra of LWS; this is known as the chloride effect. Although the two amino acid substitutions of His197 and Lys200 influence the chloride effect, the molecular mechanism of chloride binding, which underlies the spectral tuning, has yet to be clarified. In this study, we applied ATR-FTIR spectroscopy to monkey green (MG) pigment to gain structural information of the chloride binding site. The results suggest that chloride binding stabilizes the ß-sheet structure on the extracellular side loop with perturbation of the retinal polyene chain, promotes a hydrogen bonding exchange with the hydroxyl group of Tyr, and alters the protonation state of carboxylate. Combining with the results of the binding analyses of various anions (Br , I and NO ), our findings suggest that the anion binding pocket is organized for only Cl (or Br ) to stabilize conformation around the retinal chromophore, which is functionally relevant with absorbing long wavelength light.
[Mh] Termos MeSH primário: Cloretos/química
Pigmentos da Retina/química
[Mh] Termos MeSH secundário: Animais
Ânions/química
Sítios de Ligação
Cercopithecus aethiops
Cloretos/metabolismo
Células HEK293
Seres Humanos
Ligações de Hidrogênio
Estrutura Secundária de Proteína
Proteínas Recombinantes/biossíntese
Proteínas Recombinantes/química
Proteínas Recombinantes/isolamento & purificação
Pigmentos da Retina/genética
Pigmentos da Retina/metabolismo
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anions); 0 (Chlorides); 0 (Recombinant Proteins); 0 (Retinal Pigments)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.1039/c7cp07277e


  7 / 13023 MEDLINE  
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[PMID]:29221868
[Au] Autor:Zhu G; Gao X; Wang X; Wang J; Fan J
[Ad] Endereço:School of Environment, Henan Key Laboratory for Environmental Pollution Control, Key Laboratory for Yellow River and Huai River Water Environmental Pollution Control, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, PR China.
[Ti] Título:Influence of hydrogen bond accepting ability of anions on the adsorption performance of ionic liquid surface molecularly imprinted polymers.
[So] Source:J Chromatogr A;1532:40-49, 2018 Jan 12.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:To illuminate the influence mechanism of anionic structure of ionic liquids (ILs) on the adsorption performance of surface molecularly imprinted polymers (MIPs), in this work, six newly designed MIPs were prepared on the surface of amino-poly(styrene-divinylbenzene) particles by using imidazolium ILs with the same cation [C mim] but different anions (Cl, CH SO , PF , BF , C F O , C F SO ) as template molecules, methacrylic acid as functional monomer, and ethylene dimethacrylate as cross-linker. The resulting MIP materials were characterized by IR and SEM, and the influence of hydrogen bond accepting ability of anions on the adsorption performance of the MIPs for the ILs was investigated in acetonitrile. It was found that adsorption capacity of the MIPs towards the ILs decreased in the order MIP > MIP ≥ MIP and MIP > MIP > MIP , which is in good agreement with the ability of anions of the ILs to form hydrogen bonds. Ultraviolet, H-NMR and Cl-NMR spectroscopy was then used to study the interactions of anions of the ILs with the functional monomer. It was found that the hydrogen bond interaction between anions of the ILs and acidic proton of the functional monomer was the main driving force for the high adsorption selectivity of the imprinted polymers, and the stronger hydrogen bond interaction indicates higher binding capacity and higher selectivity of the polymers towards the ILs. It was also verified that the ILs with stronger hydrogen bond accepting ability of anions could be selectively extracted by the corresponding IL-MIPs. These results may provide new insight into the recognition mechanism of MIPs for ILs, and are also useful for the rational design of this new class of imprinting materials.
[Mh] Termos MeSH primário: Ânions/química
Líquidos Iônicos/química
Impressão Molecular
Polímeros/química
[Mh] Termos MeSH secundário: Adsorção
Hidrogênio
Ligações de Hidrogênio
Metacrilatos/química
Espectroscopia de Prótons por Ressonância Magnética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anions); 0 (Ionic Liquids); 0 (Methacrylates); 0 (Polymers); 1CS02G8656 (methacrylic acid); 7BK5G69305 (ethylene dimethacrylate); 7YNJ3PO35Z (Hydrogen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171210
[St] Status:MEDLINE


  8 / 13023 MEDLINE  
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[PMID]:27770747
[Au] Autor:Lee H
[Ad] Endereço:Department of Chemical Engineering, Dankook University, Yongin, 448-701, South Korea. Electronic address: leeh@dankook.ac.kr.
[Ti] Título:Effect of polyelectrolyte size on multilayer conformation and dynamics at different temperatures and salt concentrations.
[So] Source:J Mol Graph Model;70:246-252, 2016 11.
[Is] ISSN:1873-4243
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Polyelectrolyte bilayers, which consist of poly-l-lysine (PLL) and hyaluronic acid (HA) were simulated with lipid membranes at different temperatures and ion concentrations. Starting with the sequential deposition of PLL and HA above the membrane surface, PLL and HA become completely mixed, leading to the formation of stable bilayers. PLL/HA bilayers are thicker at higher salt concentration because of weakened electrostatic interactions between PLLs and membrane lipids, in agreement with experiments. This salt effect decreases as PLL size increases. Also, bilayers become thinner at higher temperature because of the increased surface area of membrane. In particular, regardless of temperature and salt concentration, larger PLLs induce thicker bilayers, although larger PLLs have lower diffusivities than do smaller ones. Bilayers with larger PLLs show larger vacancy (more water) inside the bilayer, indicating that larger PLLs are less densely stacked on membrane surface than do smaller ones and thus form the thicker bilayer. These findings show the lower diffusivity of larger polyelectrolytes, which supports the experimental observation regarding the restricted diffusion of large polymers, and also imply the dependence of bilayer thickness on the polymer size.
[Mh] Termos MeSH primário: Conformação Molecular
Polieletrólitos/química
Cloreto de Sódio/química
Temperatura Ambiente
[Mh] Termos MeSH secundário: Ânions
Difusão
Ácido Hialurônico/química
Bicamadas Lipídicas/química
Lipídeos/química
Simulação de Dinâmica Molecular
Fosfatidilcolinas/química
Polilisina/química
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anions); 0 (Lipid Bilayers); 0 (Lipids); 0 (Phosphatidylcholines); 0 (Polyelectrolytes); 059QF0KO0R (Water); 25104-18-1 (Polylysine); 451W47IQ8X (Sodium Chloride); 9004-61-9 (Hyaluronic Acid); TE895536Y5 (1-palmitoyl-2-oleoylphosphatidylcholine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


  9 / 13023 MEDLINE  
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[PMID]:29322852
[Au] Autor:Vullo D; Syrjänen L; Kuuslahti M; Parkkila S; Supuran CT
[Ad] Endereço:a Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica , Università degli Studi di Firenze , Sesto Fiorentino (Firenze) , Italy.
[Ti] Título:Anion inhibition studies of a beta carbonic anhydrase from the malaria mosquito Anopheles gambiae.
[So] Source:J Enzyme Inhib Med Chem;33(1):359-363, 2018 Dec.
[Is] ISSN:1475-6374
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An anion inhibition study of the ß-class carbonic anhydrase, AgaCA, from the malaria mosquito Anopheles gambiae is reported. A series of simple as well as complex inorganic anions, and small molecules known to interact with CAs were included in the study. Bromide, iodide, bisulphite, perchlorate, perrhenate, perruthenate, and peroxydisulphate were ineffective AgaCA inhibitors, with K s > 200 mM. Fluoride, chloride, cyanate, thiocyanate, cyanide, bicarbonate, carbonate, nitrite, nitrate, sulphate, stannate, selenate, tellurate, diphosphate, divanadate, tetraborate, selenocyanide, and trithiocarbonate showed K s in the range of 1.80-9.46 mM, whereas N,N-diethyldithiocarbamate was a submillimolar AgaCA inhibitor (K of 0.65 mM). The most effective AgaCA inhibitors were sulphamide, sulphamic acid, phenylboronic acid and phenylarsonic acid, with inhibition constants in the range of 21-84 µM. The control of insect vectors responsible of the transmission of many protozoan diseases is rather difficult nowadays, and finding agents which can interfere with these processes, as the enzyme inhibitors investigated here, may arrest the spread of these diseases worldwide.
[Mh] Termos MeSH primário: Anopheles/enzimologia
Inibidores da Anidrase Carbônica/farmacologia
Anidrases Carbônicas/metabolismo
[Mh] Termos MeSH secundário: Animais
Ânions/síntese química
Ânions/química
Ânions/farmacologia
Inibidores da Anidrase Carbônica/síntese química
Inibidores da Anidrase Carbônica/química
Relação Dose-Resposta a Droga
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anions); 0 (Carbonic Anhydrase Inhibitors); EC 4.2.1.1 (Carbonic Anhydrases)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1080/14756366.2017.1421182


  10 / 13023 MEDLINE  
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[PMID]:28873634
[Au] Autor:Falkeborg MF; Roda-Serrat MC; Burnæs KL; Nielsen ALD
[Ad] Endereço:Centre for Food Technology, Danish Technological Institute, Kongsvang alle 29, DK-8000 Aarhus C, Denmark. Electronic address: mfa@dti.dk.
[Ti] Título:Stabilising phycocyanin by anionic micelles.
[So] Source:Food Chem;239:771-780, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phycocyanins are pigment-protein complexes with potential application as natural food colourants. The perceived colour of phycocyanins varies with pH, and a method to stabilise the colour over a broad range of pH values is requested by the food industry. In this work, the stabilising effect of sodium dodecyl sulphate (SDS) micelles on pH-induced colour variations of phycocyanin was examined. SDS was shown to stabilise the blue conformation of phycocyanin, preventing formation of the green conformation, which is prevalent at low pH. The studies indicated that the stabilising effect occurred through interaction or entrapment of the non-protonated, circular helical (blue) structure of phycocyanin and the anionic SDS micelles. The interaction prevented conversion into protonated, partially unfolded (green) phycocyanin species. This information opens for new possibilities to stabilise the blue conformation of phycocyanin and to apply the stabilised form in food products as a natural blue food colourant.
[Mh] Termos MeSH primário: Ficocianina/química
[Mh] Termos MeSH secundário: Ânions
Micelas
Dodecilsulfato de Sódio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anions); 0 (Micelles); 11016-15-2 (Phycocyanin); 368GB5141J (Sodium Dodecyl Sulfate)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE



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