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  1 / 1522 MEDLINE  
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[PMID]:29254315
[Au] Autor:Akhtar T; Sheikh N; Shan T; Ghazanfar R
[Ad] Endereço:Cell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Q-A Campus, Lahore, Pakistan.
[Ti] Título:Tacrolimus induced nephrotoxicity and pulmonary toxicity in Wistar rats.
[So] Source:J Biol Regul Homeost Agents;31(4):1061-1066, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Transplantation has evolved into an accepted treatment for end-stage organ failure. The major limitation for solid organ transplantation is organ rejection, which is an adaptive immune response caused by the activation of T-cells. Immunosuppressant drugs are used to overcome this problem. Tacrolimus is a powerful immunosuppressive drug which is used to minimize the risk of organ rejection. The present study was designed to find the toxic effects of tacrolimus on lungs and kidneys. Wistar rats were divided into 4 experimental groups and one control group (n=9). Each rat of the experimental group was orally given the aqueous suspension of tacrolimus powder (3mg/ml) and dissected after 6, 12, 24 and 48 hours of tacrolimus suspension dose. Lungs and kidneys were excised and processed for histopathological and histochemical alterations. Kidney tissues presented signs of toxic potential on tissue architecture such as increased interstitial spaces, necrosis, especially acute tubular necrosis, glomerular shrinkage, dilated blood vessels and enlargement of Bowman’s capsule. Lung sections also confirmed the toxic potential, characterized by bronchiolar wall thickening, alveolar cells necrosis, collapsing of alveolar spaces and interstitial round cell infiltrate. Results of Prussian blue iron staining showed no iron deposition in kidney architecture while in lung sections, iron accumulation was evident. Taken together from these observations we can conclude that tacrolimus may induce toxicity to a certain extent with structural distortion of the kidneys and lungs.
[Mh] Termos MeSH primário: Imunossupressores/toxicidade
Rim/efeitos dos fármacos
Pulmão/efeitos dos fármacos
Tacrolimo/toxicidade
[Mh] Termos MeSH secundário: Animais
Ferrocianetos
Histocitoquímica
Rim/patologia
Rim/ultraestrutura
Pulmão/patologia
Pulmão/ultraestrutura
Microtomia
Ratos
Ratos Wistar
Inclusão do Tecido
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ferrocyanides); 0 (Immunosuppressive Agents); TLE294X33A (ferric ferrocyanide); WM0HAQ4WNM (Tacrolimus)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


  2 / 1522 MEDLINE  
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[PMID]:28873536
[Au] Autor:Soo Lim H; Young Hwang J; Choi E; Lee G; Sun Yoon S; Kim M
[Ad] Endereço:Food Additives and Packaging Division, Ministry of Food and Drug Safety, Cheongju, Chungcheongbuk-do 28159, Republic of Korea.
[Ti] Título:Development and validation of HPLC method for the determination of ferrocyanide ion in food grade salts.
[So] Source:Food Chem;239:1167-1174, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A rapid, simple, and reliable HPLC method was developed and validated to determine the presence of ferrocyanide ions (FeCNs) in food grade salts. An analytical column coupled with a guard column and mobile phase comprised of sodium perchlorate and sodium hydroxide (NaOH) were employed at a detection wavelength of 221nm. Samples were dissolved in 0.02M NaOH solution and filtered. For processed salts including herbs and spices, a C cartridge was applied to minimize interference from salt matrices. The method validation was based on linearity, accuracy (recovery), precision, LOD, LOQ, and measurement uncertainty. This method exhibits good linearity from 0.1-10mg/L (r =0.9999). The LOD and LOQ values were determined to be 0.02 and 0.07mg/kg, respectively. The FeCN recoveries in six salt matrices ranged from 80.3-102.2% (RSD=0.3-4.4%). These results indicate that the proposed method is suitable for FeCN ion determination in various food grade salts.
[Mh] Termos MeSH primário: Ferrocianetos/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Indicadores e Reagentes
Íons
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ferrocyanides); 0 (Indicators and Reagents); 0 (Ions); FLX0VIC39Y (hexacyanoferrate II)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  3 / 1522 MEDLINE  
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[PMID]:28822912
[Au] Autor:Li SL; Bai MD; Hsiao CJ; Cheng SS; Nealson KH
[Ad] Endereço:Department of Earth Sciences, University of Southern California, Los Angeles, CA 90089, USA; Department of Environmental Engineering, National Cheng Kung University, No. 1, University Road, Tainan, 701, Taiwan, ROC. Electronic address: reedli0227@ntu.edu.tw.
[Ti] Título:A metabolic-activity-detecting approach to life detection: Restoring a chemostat from stop-feeding using a rapid bioactivity assay.
[So] Source:Bioelectrochemistry;118:147-153, 2017 Dec.
[Is] ISSN:1878-562X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A mediated glassy carbon electrode covered by a thin-film polyviologen was used in the present study to rapidly detect bioactivity in a mixed-culture chemostat (dominated by Clostridium sp.). With the addition of 1mM hexacyanoferrate and 9mM glucose, the current increasing rate (dI/dt) measured under a poised potential of 500mV (vs. Ag/AgCl) can be defined as the quantity of metabolic activity. In the experiment of restoring the chemostat from stop-feeding, it is suggested that when the dI/dt was >2µAmin , the influent pump could be directly turned on to maintain the high dilution rate of 0.5h ; when the dI/dt was lower than 2µAmin , reducing the dilution rate would be needed to avoid cell wash out. Since the soluble mediators and polyviologen film will enhance performances by favorable electron transfer and positively charged surfaces, respectively, we suggest that the method can also be employed to detect the bioactivities in environmental samples.
[Mh] Termos MeSH primário: Reatores Biológicos/microbiologia
Clostridium/efeitos dos fármacos
Clostridium/metabolismo
[Mh] Termos MeSH secundário: Clostridium/citologia
Relação Dose-Resposta a Droga
Condutividade Elétrica
Transporte de Elétrons/efeitos dos fármacos
Espaço Extracelular/efeitos dos fármacos
Espaço Extracelular/metabolismo
Fermentação/efeitos dos fármacos
Ferrocianetos/farmacologia
Glucose/farmacologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ferrocyanides); FLX0VIC39Y (hexacyanoferrate II); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170821
[St] Status:MEDLINE


  4 / 1522 MEDLINE  
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[PMID]:28686995
[Au] Autor:Soda N; Arotiba OA
[Ad] Endereço:Department of Applied Chemistry, University of Johannesburg, South Africa.
[Ti] Título:A polyamidoamine dendrimer-streptavidin supramolecular architecture for biosensor development.
[So] Source:Bioelectrochemistry;118:14-18, 2017 Dec.
[Is] ISSN:1878-562X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A novel polyamidoamine dendrimer-streptavidin supramolecular architecture suitable as a versatile platform for biosensor development is reported. The dendrimer was electrodeposited on a glassy carbon electrode via cyclic voltammetry. The dendrimer electrode was further modified with streptavidin by electrostatic attraction upon drop coating. The platform i.e. the dendrimer-streptavidin modified electrode was electrochemically interrogated in phosphate buffer, ferrocyanide and H O . The dendrimer-streptavidin platform was used in the preparation of a simple DNA biosensor as a proof of concept. The supramolecular architecture of dendrimer-streptavidin was stable, electroactive and thus lends itself as a versatile immobilisation layer for any biotinylated bioreceptors in biosensor development.
[Mh] Termos MeSH primário: Técnicas Biossensoriais/métodos
Dendrímeros/química
Poliaminas/química
Estreptavidina/química
[Mh] Termos MeSH secundário: Eletroquímica
Ferrocianetos/química
Peróxido de Hidrogênio/química
Fosfatos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dendrimers); 0 (Ferrocyanides); 0 (Phosphates); 0 (Poly(amidoamine)); 0 (Polyamines); 9013-20-1 (Streptavidin); BBX060AN9V (Hydrogen Peroxide); FLX0VIC39Y (hexacyanoferrate II)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE


  5 / 1522 MEDLINE  
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[PMID]:28255343
[Au] Autor:Yang Y; Jing L; Li X; Lin L; Yue X; Dai Z
[Ad] Endereço:School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.
[Ti] Título:Hyaluronic Acid Conjugated Magnetic Prussian Blue@Quantum Dot Nanoparticles for Cancer Theranostics.
[So] Source:Theranostics;7(2):466-481, 2017.
[Is] ISSN:1838-7640
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:A multifunctional nanotheranostic agent was developed by conjugating both hyaluronic acid and bovine serum albumin coated CuInS -ZnS quantum dots onto the surface of magnetic Prussian blue nanoparticles. The obtained nanoagent could serve as an efficient contrast agent to simultaneously enhance near infrared (NIR) fluorescence and magnetic resonance (MR) imaging greatly. The coexistence of magnetic core and CD44 ligand hyaluronic acid was found to largely improve the specific uptake of the nanoagent by CD44 overexpressed HeLa cells upon applying an external magnetic field. Both NIR fluorescence and MR imaging proved high accumulation of the nanoagent at tumor site due to its excellent CD44 receptor/magnetic dual targeting capability. After intravenous injection of the nanoagent and treatment of external magnetic field, the tumor in nude mice was efficiently ablated upon NIR laser irradiation and the tumor growth inhibition was more than 89.95%. Such nanotheranostic agent is of crucial importance for accurately identifying the size and location of the tumor before therapy, monitoring the photothermal treatment procedure in real-time during therapy, assessing the effectiveness after therapy.
[Mh] Termos MeSH primário: Adenocarcinoma/diagnóstico por imagem
Adenocarcinoma/terapia
Ferrocianetos/administração & dosagem
Nanopartículas de Magnetita/administração & dosagem
Fármacos Fotossensibilizantes/administração & dosagem
Pontos Quânticos/administração & dosagem
Nanomedicina Teranóstica/métodos
[Mh] Termos MeSH secundário: Animais
Meios de Contraste/administração & dosagem
Modelos Animais de Doenças
Portadores de Fármacos/administração & dosagem
Células HeLa
Xenoenxertos
Seres Humanos
Hipertermia Induzida
Lasers
Campos Magnéticos
Imagem por Ressonância Magnética/métodos
Camundongos Endogâmicos BALB C
Camundongos Nus
Imagem Óptica/métodos
Fotoquimioterapia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (Drug Carriers); 0 (Ferrocyanides); 0 (Magnetite Nanoparticles); 0 (Photosensitizing Agents); TLE294X33A (ferric ferrocyanide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE
[do] DOI:10.7150/thno.17411


  6 / 1522 MEDLINE  
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[PMID]:28183644
[Au] Autor:Manasa G; Mascarenhas RJ; Satpati AK; D'Souza OJ; Dhason A
[Ad] Endereço:Electrochemistry Research Group, Department of Chemistry, St. Joseph's College, Lalbagh Road, Bangalore, 560027, Karnataka, India.
[Ti] Título:Facile preparation of poly(methylene blue) modified carbon paste electrode for the detection and quantification of catechin.
[So] Source:Mater Sci Eng C Mater Biol Appl;73:552-561, 2017 Apr 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Free radicals are formed as byproducts of metabolism, and are highly unstable due to the presence of unpaired electrons. They readily react with other important cellular components such as DNA causing them damage. Antioxidants such as (+)-catechin (CAT), neutralize free radicals in the blood stream. Hence there is a need for detection and quantification of catechin concentration in various food sources and beverages. Electro-oxidative properties of catechin were investigated using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). A carbon paste working electrode modified by electropolymerizing methylene blue (MB) was fabricated. Field emission scanning electron microscopy (FESEM) and atomic force microscopy (AFM) techniques were used to study the surface morphology of the electrode. Quasi-reversible electron transfer reaction occurred at +0.260V through a diffusion controlled process. In comparison to the bare carbon paste electrode (CPE), there was a significant 5.3 times increment in anodic current sensitivity at the modified electrode at physiological pH. Our findings indicate that for the electro-oxidation of CAT, CPE is a better base material for electropolymerization of MB compared to glassy carbon electrode (GCE). Nyquist plot followed the theoretical shape, indicating low interfacial charge transfer resistance of 0.095kΩ at the modified electrode. Calibration plots obtained by DPV were linear in two ranges of 1.0×10 to 1.0×10 and 1.0×10 to 0.1×10 M. The limit of detection (LOD) and limit of quantification (LOQ) was 4.9nM and 14nM respectively. Application of the developed electrode was demonstrated by detecting catechin in green tea and spiked fruit juice with satisfactory recoveries. The sensor was stable, sensitive, selective and reproducible.
[Mh] Termos MeSH primário: Carbono/química
Catequina/análise
Azul de Metileno/química
[Mh] Termos MeSH secundário: Bebidas/análise
Calibragem
Catequina/química
Espectroscopia Dielétrica
Eletricidade
Eletroquímica
Eletrodos
Elétrons
Ferrocianetos/química
Frutas/química
Concentração de Íons de Hidrogênio
Cinética
Microscopia de Força Atômica
Oxirredução
Polimerização
Reprodutibilidade dos Testes
Soluções
Propriedades de Superfície
Chá/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ferrocyanides); 0 (Solutions); 0 (Tea); 7440-44-0 (Carbon); 8R1V1STN48 (Catechin); GTP1P30292 (potassium ferrocyanide); T42P99266K (Methylene Blue)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170903
[Lr] Data última revisão:
170903
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE


  7 / 1522 MEDLINE  
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[PMID]:28024640
[Au] Autor:Qiu W; Zhu Q; Gao F; Gao F; Huang J; Pan Y; Wang Q
[Ad] Endereço:College of Chemistry and Environment, Fujian Province Key Laboratory of Morden Analytical Science and Separation Technology, Minnan Normal University, Zhangzhou 363000, PR China.
[Ti] Título:Graphene oxide directed in-situ synthesis of Prussian blue for non-enzymatic sensing of hydrogen peroxide released from macrophages.
[So] Source:Mater Sci Eng C Mater Biol Appl;72:692-700, 2017 Mar 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A novel electrochemical non-enzymatic hydrogen peroxide (H O ) sensor has been developed based on Prussian blue (PB) and electrochemically reduced graphene oxide (ERGO). The GO was covalently modified on glassy carbon electrode (GCE), and utilized as a directing platform for in-situ synthesis of electroactive PB. Then the GO was electrochemically treated to reduction form to improve the effective surface area and electroactivity of the sensing interface. The fabrication process was characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX) and atomic force microscopy (AFM). The results showed that the rich oxygen containing groups play a crucial role for the successful synthesis of PB, and the obtained PB layer on the covalently immobilized GO has good stability. Electrochemical sensing assay showed that the modified electrode had tremendous electrocatalytic property for the reduction of H O . The steady-state current response increased linearly with H O concentrations from 5µM to 1mM with a fast response time (less than 3s). The detection limit was estimated to be 0.8µM. When the sensor was applied for determination of H O released from living cells of macrophages, satisfactory results were achieved.
[Mh] Termos MeSH primário: Técnicas Eletroquímicas
Ferrocianetos/química
Grafite/química
Peróxido de Hidrogênio/análise
[Mh] Termos MeSH secundário: Animais
Carbono/química
Linhagem Celular
Técnicas Eletroquímicas/instrumentação
Eletrodos
Ferrocianetos/síntese química
Limite de Detecção
Lipopolissacarídeos/toxicidade
Macrófagos/citologia
Macrófagos/efeitos dos fármacos
Macrófagos/metabolismo
Camundongos
Microscopia de Força Atômica
Microscopia Eletrônica de Varredura
Oxirredução
Óxidos/química
Espectrometria por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ferrocyanides); 0 (Lipopolysaccharides); 0 (Oxides); 7440-44-0 (Carbon); 7782-42-5 (Graphite); BBX060AN9V (Hydrogen Peroxide); TLE294X33A (ferric ferrocyanide)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161228
[St] Status:MEDLINE


  8 / 1522 MEDLINE  
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[PMID]:27911491
[Au] Autor:Zhu X; Kim T; Rahimi M; Gorski CA; Logan BE
[Ad] Endereço:Department of Civil and Environmental Engineering, Penn State University, University Park, PA, 16802, USA.
[Ti] Título:Integrating Reverse-Electrodialysis Stacks with Flow Batteries for Improved Energy Recovery from Salinity Gradients and Energy Storage.
[So] Source:ChemSusChem;10(4):797-803, 2017 Feb 22.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Salinity gradient energy can be directly converted into electrical power by using reverse electrodialysis (RED) and other technologies, but reported power densities have been too low for practical applications. Herein, the RED stack performance was improved by using 2,6-dihydroxyanthraquinone and ferrocyanide as redox couples. These electrolytes were then used in a flow battery to produce an integrated RED stack and flow battery (RED-FB) system capable of capturing, storing, and discharging salinity gradient energy. Energy captured from the RED stack was discharged in the flow battery at a maximum power density of 3.0 kW m -anode, which was similar to the flow batteries charged by electrical power and could be used for practical applications. Salinity gradient energy captured from the RED stack was recovered from the electrolytes as electricity with 30 % efficiency, and the maximum energy density of the system was 2.4 kWh m -anolyte. The combined RED-FB system overcomes many limitations of previous approaches to capture, store, and use salinity gradient energy from natural or engineered sources.
[Mh] Termos MeSH primário: Fontes Geradoras de Energia
Salinidade
[Mh] Termos MeSH secundário: Antraquinonas
Fontes de Energia Elétrica
Eletricidade
Técnicas Eletroquímicas/métodos
Eletrólitos
Ferrocianetos
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthraquinones); 0 (Electrolytes); 0 (Ferrocyanides); FLX0VIC39Y (hexacyanoferrate II); W83883330W (2,6-dihydroxyanthraquinone)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170502
[Lr] Data última revisão:
170502
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201601220


  9 / 1522 MEDLINE  
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[PMID]:27865108
[Au] Autor:Wang Y; Gao C; Ge S; Zhang L; Yu J; Yan M
[Ad] Endereço:School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.
[Ti] Título:Self-powered sensing platform equipped with Prussian blue electrochromic display driven by photoelectrochemical cell.
[So] Source:Biosens Bioelectron;89(Pt 2):728-734, 2017 Mar 15.
[Is] ISSN:1873-4235
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:By incorporating the Prussian Blue (PB) electrochromic display as cathode, a solar-driven photoelectrochemical (PEC) cell was constructed through combining sandwich-structured graphite-like carbon nitride (g-C N )-Au-branched-titanium dioxide (B-TiO ) nanorods as photoanode for self-powered hydrogen peroxide (H O ) sensing, which exhibits both direct photoelectrochemical and electrochromic response. The gold nanoparticles (Au NPs) sandwiched between the B-TiO nanorods and the g-C N layer served as electron relay as well as plasmonic photosensitizer to enhance the solar-to-chemical energy conversion efficiency. Owing to the effective disproportionation of H O and specific recognition of mannose on cell surface, concanavalin-A conjugated porous AuPd alloy nanoparticles were introduced as the catalytically active nanolabels promoting generation of hydroxyl radicals (·OH). Based on the cleavage of DNA with the participation of ·OH radicals generated by the decomposition of H O under the catalysis of AuPd alloy result in the disassembly of cancer cells to achieve further signal enhancement. The multiple-signal-output sensing response not only provides a promising strategy for different analytical purposes based on novel stimuli-responsive materials, but also enhances the reliability in the analyte detection.
[Mh] Termos MeSH primário: Técnicas Biossensoriais/instrumentação
Corantes/química
Ferrocianetos/química
Grafite/química
Peróxido de Hidrogênio/análise
Nanotubos/química
Titânio/química
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Colorimetria/instrumentação
Técnicas Eletroquímicas/instrumentação
Eletrodos
Ouro/química
Seres Humanos
Nanotubos/ultraestrutura
Neoplasias/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coloring Agents); 0 (Ferrocyanides); 15FIX9V2JP (titanium dioxide); 7440-57-5 (Gold); 7782-42-5 (Graphite); BBX060AN9V (Hydrogen Peroxide); D1JT611TNE (Titanium); TLE294X33A (ferric ferrocyanide)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161120
[St] Status:MEDLINE


  10 / 1522 MEDLINE  
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[PMID]:27836615
[Au] Autor:Yang P; Peng J; Chu Z; Jiang D; Jin W
[Ad] Endereço:State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing 210009, PR China.
[Ti] Título:Facile synthesis of Prussian blue nanocubes/silver nanowires network as a water-based ink for the direct screen-printed flexible biosensor chips.
[So] Source:Biosens Bioelectron;92:709-717, 2017 Jun 15.
[Is] ISSN:1873-4235
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The large-scale fabrication of nanocomposite based biosensors is always a challenge in the technology commercialization from laboratory to industry. In order to address this issue, we have designed a facile chemical method of fabricated nanocomposite ink applied to the screen-printed biosensor chip. This ink can be derived in the water through the in-situ growth of Prussian blue nanocubes (PBNCs) on the silver nanowires (AgNWs) to construct a composite nanostructure by a facile chemical method. Then a miniature flexible biosensor chip was screen-printed by using the prepared nanocomposite ink. Due to the synergic effects of the large specific surface area, high conductivity and electrocatalytic activity from AgNWs and PBNCs, the as-prepared biosensor chip exhibited a fast response (<3s), a wider linear response from 0.01 to 1.3mM with an ultralow LOD=5µm, and the ultrahigh sensitivities of 131.31 and 481.20µAmM cm for the detections of glucose and hydrogen peroxide (H O ), respectively. Furthermore, the biosensor chip exhibited excellent stability, good reproducibility and high anti-interference ability towards physiological substances under a very low working potential of -0.05. Hence, the proposed biosensor chip also showed a promising potential for the application in practical analysis.
[Mh] Termos MeSH primário: Técnicas Biossensoriais/instrumentação
Glicemia/análise
Ferrocianetos/química
Peróxido de Hidrogênio/análise
Dispositivos Lab-On-A-Chip
Nanoestruturas/química
Prata/química
[Mh] Termos MeSH secundário: Animais
Aspergillus niger/enzimologia
Eletrodos
Enzimas Imobilizadas/química
Glucose Oxidase/química
Tinta
Nanoestruturas/ultraestrutura
Nanofios/química
Nanofios/ultraestrutura
Coelhos
Reprodutibilidade dos Testes
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Enzymes, Immobilized); 0 (Ferrocyanides); 059QF0KO0R (Water); 3M4G523W1G (Silver); BBX060AN9V (Hydrogen Peroxide); EC 1.1.3.4 (Glucose Oxidase); TLE294X33A (ferric ferrocyanide)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161113
[St] Status:MEDLINE



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